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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EPHX2-PTK2B (FusionGDB2 ID:26983)

Fusion Gene Summary for EPHX2-PTK2B

check button Fusion gene summary
Fusion gene informationFusion gene name: EPHX2-PTK2B
Fusion gene ID: 26983
HgeneTgene
Gene symbol

EPHX2

PTK2B

Gene ID

2053

2185

Gene nameepoxide hydrolase 2protein tyrosine kinase 2 beta
SynonymsABHD20|CEH|SEHCADTK|CAKB|FADK2|FAK2|PKB|PTK|PYK2|RAFTK
Cytomap

8p21.2-p21.1

8p21.2

Type of geneprotein-codingprotein-coding
Descriptionbifunctional epoxide hydrolase 2epoxide hydrataseepoxide hydrolase 2, cytoplasmicepoxide hydrolase 2, cytosolicepoxide hydrolase, solubleprotein-tyrosine kinase 2-betaCAK-betaFADK 2PTK2B protein tyrosine kinase 2 betacalcium-dependent tyrosine kinasecalcium-regulated non-receptor proline-rich tyrosine kinasecell adhesion kinase betafocal adhesion kinase 2proline-rich tyrosine kinas
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000521400, ENST00000517536, 
ENST00000521780, ENST00000380476, 
ENST00000518379, ENST00000520666, 
ENST00000544172, ENST00000397501, 
ENST00000338238, ENST00000346049, 
ENST00000420218, ENST00000517339, 
ENST00000519650, ENST00000397497, 
Fusion gene scores* DoF score3 X 2 X 3=189 X 10 X 4=360
# samples 410
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPHX2 [Title/Abstract] AND PTK2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEPHX2(27375589)-PTK2B(27308266), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEPHX2

GO:0010628

positive regulation of gene expression

18974052

HgeneEPHX2

GO:0016311

dephosphorylation

12574508

HgeneEPHX2

GO:0042632

cholesterol homeostasis

18974052

HgeneEPHX2

GO:0046272

stilbene catabolic process

8342951

HgeneEPHX2

GO:0046839

phospholipid dephosphorylation

12574510

HgeneEPHX2

GO:0097176

epoxide metabolic process

22798687

TgenePTK2B

GO:0010595

positive regulation of endothelial cell migration

21245381

TgenePTK2B

GO:0018108

peptidyl-tyrosine phosphorylation

7544443

TgenePTK2B

GO:0038083

peptidyl-tyrosine autophosphorylation

9545257|10518561

TgenePTK2B

GO:0043267

negative regulation of potassium ion transport

7544443

TgenePTK2B

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

10022914|10518561|21245381

TgenePTK2B

GO:2000058

regulation of ubiquitin-dependent protein catabolic process

19880522


check buttonFusion gene breakpoints across EPHX2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PTK2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-HQ-A2OEEPHX2chr8

27375589

+PTK2Bchr8

27308265

+
ChimerDB4BLCATCGA-HQ-A2OE-01AEPHX2chr8

27375589

+PTK2Bchr8

27308266

+
ChimerDB4BLCATCGA-HQ-A2OE-01AEPHX2chr8

27375589

-PTK2Bchr8

27308266

+


Top

Fusion Gene ORF analysis for EPHX2-PTK2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000521400ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521400ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521400ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521400ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521400ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521400ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000521400ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000521400ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000517536ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000517536ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000517536ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000517536ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000517536ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000517536ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000517536ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000517536ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521780ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521780ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521780ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521780ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521780ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521780ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000521780ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000521780ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000380476ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000380476ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000380476ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000380476ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000380476ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000380476ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000380476ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000380476ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000518379ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000518379ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000518379ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000518379ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000518379ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000518379ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000518379ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
5CDS-intronENST00000518379ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
intron-3CDSENST00000520666ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
intron-3CDSENST00000520666ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
intron-3CDSENST00000520666ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
intron-3CDSENST00000520666ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
intron-3CDSENST00000520666ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
intron-3CDSENST00000520666ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
intron-intronENST00000520666ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
intron-intronENST00000520666ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308265

+
In-frameENST00000521400ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521400ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521400ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521400ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521400ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521400ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000521400ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000521400ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000517536ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000517536ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000517536ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000517536ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000517536ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000517536ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000517536ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000517536ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521780ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521780ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521780ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521780ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521780ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000521780ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000521780ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000521780ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000380476ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000380476ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000380476ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000380476ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000380476ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000380476ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000380476ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000380476ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000518379ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000518379ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000518379ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000518379ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000518379ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
In-frameENST00000518379ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000518379ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
5CDS-intronENST00000518379ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
intron-3CDSENST00000520666ENST00000544172EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
intron-3CDSENST00000520666ENST00000397501EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
intron-3CDSENST00000520666ENST00000338238EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
intron-3CDSENST00000520666ENST00000346049EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
intron-3CDSENST00000520666ENST00000420218EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
intron-3CDSENST00000520666ENST00000517339EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
intron-intronENST00000520666ENST00000519650EPHX2chr8

27375589

+PTK2Bchr8

27308266

+
intron-intronENST00000520666ENST00000397497EPHX2chr8

27375589

+PTK2Bchr8

27308266

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for EPHX2-PTK2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EPHX2chr827375589+PTK2Bchr827308265+4.41E-070.9999995
EPHX2chr827375589+PTK2Bchr827308265+4.41E-070.9999995
EPHX2chr827375589+PTK2Bchr827308265+4.41E-070.9999995
EPHX2chr827375589+PTK2Bchr827308265+4.41E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EPHX2-PTK2B


check button Go to

FGviewer for the breakpoints of chr8:27375589-chr8:27308265

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPHX2chr8:27375589chr8:27308265ENST00000380476+919123_124262.0503.0RegionPhosphate binding
HgeneEPHX2chr8:27375589chr8:27308265ENST00000380476+9191_224262.0503.0RegionNote=Phosphatase
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521400+919123_124315.0556.0RegionPhosphate binding
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521400+9191_224315.0556.0RegionNote=Phosphatase
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521780+818123_124249.0490.0RegionPhosphate binding
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521780+8181_224249.0490.0RegionNote=Phosphatase
HgeneEPHX2chr8:27375589chr8:27308266ENST00000380476+919123_124262.0503.0RegionPhosphate binding
HgeneEPHX2chr8:27375589chr8:27308266ENST00000380476+9191_224262.0503.0RegionNote=Phosphatase
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521400+919123_124315.0556.0RegionPhosphate binding
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521400+9191_224315.0556.0RegionNote=Phosphatase
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521780+818123_124249.0490.0RegionPhosphate binding
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521780+8181_224249.0490.0RegionNote=Phosphatase
TgenePTK2Bchr8:27375589chr8:27308265ENST000003382382735831_869738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000003460492331831_869780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000003975012836831_869780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000004202182230831_869738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000005173392129831_869738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000005441722735831_869780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000003382382735831_869738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000003460492331831_869780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000003975012836831_869780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000004202182230831_869738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000005173392129831_869738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000005441722735831_869780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000003382382735868_1009738.0968.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308265ENST000003460492331868_1009780.01010.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308265ENST000003975012836868_1009780.01010.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308265ENST000004202182230868_1009738.0968.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308265ENST000005173392129868_1009738.0968.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308265ENST000005441722735868_1009780.01010.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308266ENST000003382382735868_1009738.0968.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308266ENST000003460492331868_1009780.01010.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308266ENST000003975012836868_1009780.01010.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308266ENST000004202182230868_1009738.0968.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308266ENST000005173392129868_1009738.0968.0RegionNote=Focal adhesion targeting (FAT)
TgenePTK2Bchr8:27375589chr8:27308266ENST000005441722735868_1009780.01010.0RegionNote=Focal adhesion targeting (FAT)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPHX2chr8:27375589chr8:27308265ENST00000380476+919259_531262.0503.0DomainAB hydrolase-1
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521400+919259_531315.0556.0DomainAB hydrolase-1
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521780+818259_531249.0490.0DomainAB hydrolase-1
HgeneEPHX2chr8:27375589chr8:27308266ENST00000380476+919259_531262.0503.0DomainAB hydrolase-1
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521400+919259_531315.0556.0DomainAB hydrolase-1
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521780+818259_531249.0490.0DomainAB hydrolase-1
HgeneEPHX2chr8:27375589chr8:27308265ENST00000380476+919553_555262.0503.0MotifMicrobody targeting signal
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521400+919553_555315.0556.0MotifMicrobody targeting signal
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521780+818553_555249.0490.0MotifMicrobody targeting signal
HgeneEPHX2chr8:27375589chr8:27308266ENST00000380476+919553_555262.0503.0MotifMicrobody targeting signal
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521400+919553_555315.0556.0MotifMicrobody targeting signal
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521780+818553_555249.0490.0MotifMicrobody targeting signal
HgeneEPHX2chr8:27375589chr8:27308265ENST00000380476+919235_555262.0503.0RegionNote=Epoxide hydrolase
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521400+919235_555315.0556.0RegionNote=Epoxide hydrolase
HgeneEPHX2chr8:27375589chr8:27308265ENST00000521780+818235_555249.0490.0RegionNote=Epoxide hydrolase
HgeneEPHX2chr8:27375589chr8:27308266ENST00000380476+919235_555262.0503.0RegionNote=Epoxide hydrolase
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521400+919235_555315.0556.0RegionNote=Epoxide hydrolase
HgeneEPHX2chr8:27375589chr8:27308266ENST00000521780+818235_555249.0490.0RegionNote=Epoxide hydrolase
TgenePTK2Bchr8:27375589chr8:27308265ENST000003382382735702_767738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000003460492331702_767780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000003975012836702_767780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000004202182230702_767738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000005173392129702_767738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST000005441722735702_767780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000003382382735702_767738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000003460492331702_767780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000003975012836702_767780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000004202182230702_767738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000005173392129702_767738.0968.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308266ENST000005441722735702_767780.01010.0Compositional biasNote=Pro-rich
TgenePTK2Bchr8:27375589chr8:27308265ENST00000338238273539_359738.0968.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308265ENST000003382382735425_683738.0968.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308265ENST00000346049233139_359780.01010.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308265ENST000003460492331425_683780.01010.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308265ENST00000397501283639_359780.01010.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308265ENST000003975012836425_683780.01010.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308265ENST00000420218223039_359738.0968.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308265ENST000004202182230425_683738.0968.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308265ENST00000517339212939_359738.0968.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308265ENST000005173392129425_683738.0968.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308265ENST00000544172273539_359780.01010.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308265ENST000005441722735425_683780.01010.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308266ENST00000338238273539_359738.0968.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308266ENST000003382382735425_683738.0968.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308266ENST00000346049233139_359780.01010.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308266ENST000003460492331425_683780.01010.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308266ENST00000397501283639_359780.01010.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308266ENST000003975012836425_683780.01010.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308266ENST00000420218223039_359738.0968.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308266ENST000004202182230425_683738.0968.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308266ENST00000517339212939_359738.0968.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308266ENST000005173392129425_683738.0968.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308266ENST00000544172273539_359780.01010.0DomainFERM
TgenePTK2Bchr8:27375589chr8:27308266ENST000005441722735425_683780.01010.0DomainProtein kinase
TgenePTK2Bchr8:27375589chr8:27308265ENST000003382382735431_439738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000003382382735503_509738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000003460492331431_439780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000003460492331503_509780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000003975012836431_439780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000003975012836503_509780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000004202182230431_439738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000004202182230503_509738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000005173392129431_439738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000005173392129503_509738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000005441722735431_439780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308265ENST000005441722735503_509780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000003382382735431_439738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000003382382735503_509738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000003460492331431_439780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000003460492331503_509780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000003975012836431_439780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000003975012836503_509780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000004202182230431_439738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000004202182230503_509738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000005173392129431_439738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000005173392129503_509738.0968.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000005441722735431_439780.01010.0Nucleotide bindingATP
TgenePTK2Bchr8:27375589chr8:27308266ENST000005441722735503_509780.01010.0Nucleotide bindingATP


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Fusion Gene Sequence for EPHX2-PTK2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EPHX2-PTK2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePTK2Bchr8:27375589chr8:27308265ENST000003382382735801_1009738.0968.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308265ENST000003460492331801_1009780.01010.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308265ENST000003975012836801_1009780.01010.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308265ENST000004202182230801_1009738.0968.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308265ENST000005173392129801_1009738.0968.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308265ENST000005441722735801_1009780.01010.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308266ENST000003382382735801_1009738.0968.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308266ENST000003460492331801_1009780.01010.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308266ENST000003975012836801_1009780.01010.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308266ENST000004202182230801_1009738.0968.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308266ENST000005173392129801_1009738.0968.0TGFB1I1
TgenePTK2Bchr8:27375589chr8:27308266ENST000005441722735801_1009780.01010.0TGFB1I1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EPHX2-PTK2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EPHX2-PTK2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEPHX2C0013221Drug toxicity1CTD_human
HgeneEPHX2C0018801Heart failure1CTD_human
HgeneEPHX2C0018802Congestive heart failure1CTD_human
HgeneEPHX2C0022660Kidney Failure, Acute1CTD_human
HgeneEPHX2C0023212Left-Sided Heart Failure1CTD_human
HgeneEPHX2C0027055Myocardial Reperfusion Injury1CTD_human
HgeneEPHX2C0036341Schizophrenia1CTD_human
HgeneEPHX2C0041755Adverse reaction to drug1CTD_human
HgeneEPHX2C0151744Myocardial Ischemia1CTD_human
HgeneEPHX2C0235527Heart Failure, Right-Sided1CTD_human
HgeneEPHX2C0242698Ventricular Dysfunction, Left1CTD_human
HgeneEPHX2C1510586Autism Spectrum Disorders1CTD_human
HgeneEPHX2C1565662Acute Kidney Insufficiency1CTD_human
HgeneEPHX2C1959583Myocardial Failure1CTD_human
HgeneEPHX2C1961112Heart Decompensation1CTD_human
HgeneEPHX2C2609414Acute kidney injury1CTD_human
TgenePTK2BC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgenePTK2BC0007114Malignant neoplasm of skin1CTD_human
TgenePTK2BC0025202melanoma1CTD_human
TgenePTK2BC0037286Skin Neoplasms1CTD_human
TgenePTK2BC0038220Status Epilepticus1CTD_human
TgenePTK2BC0270823Petit mal status1CTD_human
TgenePTK2BC0311335Grand Mal Status Epilepticus1CTD_human
TgenePTK2BC0393734Complex Partial Status Epilepticus1CTD_human
TgenePTK2BC0751522Status Epilepticus, Subclinical1CTD_human
TgenePTK2BC0751523Non-Convulsive Status Epilepticus1CTD_human
TgenePTK2BC0751524Simple Partial Status Epilepticus1CTD_human