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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EPS15-CCDC18 (FusionGDB2 ID:27020)

Fusion Gene Summary for EPS15-CCDC18

check button Fusion gene summary
Fusion gene informationFusion gene name: EPS15-CCDC18
Fusion gene ID: 27020
HgeneTgene
Gene symbol

EPS15

CCDC18

Gene ID

2060

343099

Gene nameepidermal growth factor receptor pathway substrate 15coiled-coil domain containing 18
SynonymsAF-1P|AF1P|MLLT5NY-SAR-41
Cytomap

1p32.3

1p22.1

Type of geneprotein-codingprotein-coding
Descriptionepidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1pcoiled-coil domain-containing protein 18sarcoma antigen NY-SAR-24sarcoma antigen NY-SAR-41
Modification date2020031320200313
UniProtAcc

P42566

A1A4V9

Ensembl transtripts involved in fusion geneENST00000371730, ENST00000371733, 
ENST00000396122, ENST00000493793, 
ENST00000343253, ENST00000401026, 
ENST00000338949, ENST00000334652, 
ENST00000557479, ENST00000421014, 
Fusion gene scores* DoF score17 X 13 X 11=24317 X 12 X 5=420
# samples 1711
** MAII scorelog2(17/2431*10)=-3.83794324189103
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/420*10)=-1.93288580414146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPS15 [Title/Abstract] AND CCDC18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEPS15(51934145)-CCDC18(93680303), # samples:1
EPS15(51934145)-CCDC18(93676359), # samples:1
Anticipated loss of major functional domain due to fusion event.EPS15-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EPS15-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEPS15

GO:0048268

clathrin coat assembly

12807910


check buttonFusion gene breakpoints across EPS15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCDC18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-UY-A78N-01AEPS15chr1

51934145

-CCDC18chr1

93680303

+
ChimerDB4BLCATCGA-UY-A78N-01AEPS15chr1

51934145

-CCDC18chr1

93676359

+


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Fusion Gene ORF analysis for EPS15-CCDC18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000371730ENST00000343253EPS15chr1

51934145

-CCDC18chr1

93680303

+
Frame-shiftENST00000371730ENST00000401026EPS15chr1

51934145

-CCDC18chr1

93680303

+
Frame-shiftENST00000371730ENST00000338949EPS15chr1

51934145

-CCDC18chr1

93680303

+
5CDS-5UTRENST00000371730ENST00000334652EPS15chr1

51934145

-CCDC18chr1

93680303

+
5CDS-5UTRENST00000371730ENST00000557479EPS15chr1

51934145

-CCDC18chr1

93680303

+
5CDS-intronENST00000371730ENST00000421014EPS15chr1

51934145

-CCDC18chr1

93680303

+
Frame-shiftENST00000371733ENST00000343253EPS15chr1

51934145

-CCDC18chr1

93680303

+
Frame-shiftENST00000371733ENST00000401026EPS15chr1

51934145

-CCDC18chr1

93680303

+
Frame-shiftENST00000371733ENST00000338949EPS15chr1

51934145

-CCDC18chr1

93680303

+
5CDS-5UTRENST00000371733ENST00000334652EPS15chr1

51934145

-CCDC18chr1

93680303

+
5CDS-5UTRENST00000371733ENST00000557479EPS15chr1

51934145

-CCDC18chr1

93680303

+
5CDS-intronENST00000371733ENST00000421014EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-3CDSENST00000396122ENST00000343253EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-3CDSENST00000396122ENST00000401026EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-3CDSENST00000396122ENST00000338949EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-5UTRENST00000396122ENST00000334652EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-5UTRENST00000396122ENST00000557479EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-intronENST00000396122ENST00000421014EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-3CDSENST00000493793ENST00000343253EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-3CDSENST00000493793ENST00000401026EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-3CDSENST00000493793ENST00000338949EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-5UTRENST00000493793ENST00000334652EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-5UTRENST00000493793ENST00000557479EPS15chr1

51934145

-CCDC18chr1

93680303

+
intron-intronENST00000493793ENST00000421014EPS15chr1

51934145

-CCDC18chr1

93680303

+
In-frameENST00000371730ENST00000343253EPS15chr1

51934145

-CCDC18chr1

93676359

+
In-frameENST00000371730ENST00000401026EPS15chr1

51934145

-CCDC18chr1

93676359

+
In-frameENST00000371730ENST00000338949EPS15chr1

51934145

-CCDC18chr1

93676359

+
5CDS-5UTRENST00000371730ENST00000334652EPS15chr1

51934145

-CCDC18chr1

93676359

+
5CDS-5UTRENST00000371730ENST00000557479EPS15chr1

51934145

-CCDC18chr1

93676359

+
5CDS-intronENST00000371730ENST00000421014EPS15chr1

51934145

-CCDC18chr1

93676359

+
In-frameENST00000371733ENST00000343253EPS15chr1

51934145

-CCDC18chr1

93676359

+
In-frameENST00000371733ENST00000401026EPS15chr1

51934145

-CCDC18chr1

93676359

+
In-frameENST00000371733ENST00000338949EPS15chr1

51934145

-CCDC18chr1

93676359

+
5CDS-5UTRENST00000371733ENST00000334652EPS15chr1

51934145

-CCDC18chr1

93676359

+
5CDS-5UTRENST00000371733ENST00000557479EPS15chr1

51934145

-CCDC18chr1

93676359

+
5CDS-intronENST00000371733ENST00000421014EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-3CDSENST00000396122ENST00000343253EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-3CDSENST00000396122ENST00000401026EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-3CDSENST00000396122ENST00000338949EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-5UTRENST00000396122ENST00000334652EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-5UTRENST00000396122ENST00000557479EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-intronENST00000396122ENST00000421014EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-3CDSENST00000493793ENST00000343253EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-3CDSENST00000493793ENST00000401026EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-3CDSENST00000493793ENST00000338949EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-5UTRENST00000493793ENST00000334652EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-5UTRENST00000493793ENST00000557479EPS15chr1

51934145

-CCDC18chr1

93676359

+
intron-intronENST00000493793ENST00000421014EPS15chr1

51934145

-CCDC18chr1

93676359

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371730EPS15chr151934145-ENST00000343253CCDC18chr193676359+34753191034741155
ENST00000371730EPS15chr151934145-ENST00000401026CCDC18chr193676359+3140319103009999
ENST00000371730EPS15chr151934145-ENST00000338949CCDC18chr193676359+3114319102877955
ENST00000371733EPS15chr151934145-ENST00000343253CCDC18chr193676359+35624061335611183
ENST00000371733EPS15chr151934145-ENST00000401026CCDC18chr193676359+32274061330961027
ENST00000371733EPS15chr151934145-ENST00000338949CCDC18chr193676359+3201406132964983

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371730ENST00000343253EPS15chr151934145-CCDC18chr193676359+0.0035132890.99648666
ENST00000371730ENST00000401026EPS15chr151934145-CCDC18chr193676359+0.0046179680.995382
ENST00000371730ENST00000338949EPS15chr151934145-CCDC18chr193676359+0.004718560.9952814
ENST00000371733ENST00000343253EPS15chr151934145-CCDC18chr193676359+0.0034200830.99657995
ENST00000371733ENST00000401026EPS15chr151934145-CCDC18chr193676359+0.0043957430.9956043
ENST00000371733ENST00000338949EPS15chr151934145-CCDC18chr193676359+0.0041883650.9958117

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Fusion Genomic Features for EPS15-CCDC18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EPS15chr151934144-CCDC18chr193680299+3.64E-050.99996364
EPS15chr151934144-CCDC18chr193676358+1.07E-060.9999989
EPS15chr151934144-CCDC18chr193680299+3.64E-050.99996364
EPS15chr151934144-CCDC18chr193676358+1.07E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EPS15-CCDC18


check button Go to

FGviewer for the breakpoints of chr1:51934145-chr1:93676359

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPS15

P42566

CCDC18

A1A4V9

FUNCTION: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-52515_104103.0897.0DomainEH 1
TgeneCCDC18chr1:51934145chr1:93676359ENST00000343253829438_464403.01455.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC18chr1:51934145chr1:93676359ENST00000343253829508_1309403.01455.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525173_184103.0897.0Calcium bindingNote=1
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525236_247103.0897.0Calcium bindingNote=2
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525768_850103.0897.0Compositional biasNote=Pro-rich
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525128_216103.0897.0DomainEH 2
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525160_195103.0897.0DomainEF-hand 1
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525223_258103.0897.0DomainEF-hand 2
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525224_314103.0897.0DomainEH 3
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525851_870103.0897.0DomainUIM 1
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525877_896103.0897.0DomainUIM 2
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525768_774103.0897.0MotifNote=SH3-binding
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525599_827103.0897.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525599_601103.0897.0RepeatNote=1
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525623_625103.0897.0RepeatNote=2
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525629_631103.0897.0RepeatNote=3
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525634_636103.0897.0RepeatNote=4
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525640_642103.0897.0RepeatNote=5
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525645_647103.0897.0RepeatNote=6
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525651_653103.0897.0RepeatNote=7
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525664_666103.0897.0RepeatNote=8
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525672_674103.0897.0RepeatNote=9
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525692_694103.0897.0RepeatNote=10
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525709_711103.0897.0RepeatNote=11
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525737_739103.0897.0RepeatNote=12
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525798_800103.0897.0RepeatNote=13
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525804_806103.0897.0RepeatNote=14
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-525825_827103.0897.0RepeatNote=15
TgeneCCDC18chr1:51934145chr1:93676359ENST00000343253829107_138403.01455.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC18chr1:51934145chr1:93676359ENST00000343253829170_402403.01455.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for EPS15-CCDC18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000371730_ENST00000343253_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(transcript)=3475nt_BP=319nt
TGGAAACACCATGGCTGCGGCGGCCCAGCTCTCTCTGACACAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGA
TACAGGCAATACTGGAAGGGTGTTGGCTTCTGATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTG
GGATTTAGCCGACACAGATGGCAAAGGTATCCTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATT
GGAAGTTTCACTAAGTAGTTTGAACCTGGCTGTTCCTCCACCAAGATTTTTAAAAAGAGAATTATTTGGCTTTAAATCATATCTTTCTAA
ATACCAGATGAGTAGCTTCTCAAACAAGGAAGACCGTTGCATTGGCTGCTGTGAGGCAAATAAATTGGTGATTTCGGAATTGAGAATTAA
GCTTGCAATAAAAGAGGCAGAAATTCAAAAGCTTCATGCAAACCTGACTGCAAATCAGTTATCTCAGAGTCTTATTACTTGTAATGACAG
CCAAGAAAGTAGCAAATTAAGTAGTTTAGAAACAGAACCTGTAAAGCTAGGTGGTCATCAAGTAGAAAGCGTAAAAGATCAAAATCAACA
TACTATGAACAAGCAATATGAAAAAGAGAGGCAAAGACTTGTTACTGGAATAGAAGAACTACGTACTAAGCTGATACAAATAGAAGCTGA
AAATTCTGATTTGAAGGTTAACATGGCTCACAGAACTAGTCAGTTTCAGCTGATTCAAGAGGAGCTGCTAGAGAAAGCTTCAAACTCCAG
CAAACTGGAAAGTGAAATGACAAAGAAATGTTCTCAACTTTTAACTCTTGAGAAACAGCTGGAAGAAAAGATAGTTGCTTATTCCTCTAT
TGCTGCAAAAAATGCAGAACTAGAACAGGAGCTTATGGAAAAGAATGAAAAGATAAGGAGTCTAGAAACCAATATTAATACAGAGCATGA
GAAAATTTGTTTAGCCTTTGAAAAAGCAAAGAAAATTCACTTGGAACAGCATAAAGAAATGGAAAAGCAGATTGAAAGACTTGAAGCTCA
ACTAGAGAAAAAGGACCAACAATTTAAAGAACAAGAAAAGACTATGTCCATGTTGCAACAAGATATAATATGCAAACAACATCATCTTGA
ATCACTAGATAGACTCTTGACGGAAAGCAAAGGGGAAATGAAAAAGGAAAATATGAAGAAAGATGAAGCTTTAAAAGCATTACAGAACCA
AGTATCTGAAGAAACAATCAAGGTTAGGCAACTAGATTCAGCATTGGAAATTTGTAAGGAAGAACTTGTCTTGCATTTGAATCAATTGGA
AGGAAATAAGGAAAAGTTTGAAAAACAGTTAAAGAAGAAATCTGAAGAGGTATATTGTTTACAGAAAGAGCTAAAGATAAAAAATCACAG
TCTTCAAGAGACTTCTGAGCAAAACGTTATTCTACAGCATACTCTTCAGCAACAGCAGCAAATGTTACAACAAGAGACAATTAGAAATGG
AGAGCTAGAAGATACTCAAACTAAACTTGAAAAACAGGTGTCAAAACTGGAACAAGAACTTCAAAAACAAAGGGAAAGTTCAGCTGAAAA
GTTGAGAAAAATGGAGGAGAAATGTGAATCAGCTGCACATGAAGCAGATTTGAAAAGGCAAAAAGTGATTGAGCTTACTGGCACTGCCAG
GCAAGTAAAGATTGAGATGGATCAGTACAAAGAAGAGCTGTCTAAAATGGAAAAGGAAATAATGCACCTAAAACGAGATGGAGAAAATAA
AGCAATGCACCTCTCTCAATTAGATATGATCTTAGATCAGACAAAGACAGAGCTAGAAAAGAAAACAAATGCTGTAAAGGAGTTAGAAAA
GTTACAGCACAGTACTGAAACTGAACTAACAGAAGCCTTGCAAAAACGGGAAGTACTTGAGACTGAACTACAAAATGCTCATGGAGAATT
AAAAAGTACTTTAAGACAACTCCAGGAATTGAGAGATGTACTACAGAAGGCTCAATTATCATTAGAGGAAAAATACACTACTATAAAGGA
TCTCACAGCTGAACTTAGAGAATGCAAGATGGAGATTGAAGACAAAAAGCAGGAGCTCCTTGAAATGGATCAGGCACTTAAAGAGAGAAA
TTGGGAACTAAAGCAAAGAGCAGCTCAGGTTACACATTTGGATATGACTATTCGTGAGCACAGAGGAGAAATGGAACAAAAAATAATTAA
ATTAGAAGGTACTCTGGAGAAATCAGAATTGGAACTTAAAGAATGTAACAAACAGATAGAAAGTCTGAATGACAAATTACAAAATGCTAA
AGAACAGCTTCGAGAAAAAGAGTTTATAATGCTACAAAATGAACAGGAGATAAGTCAACTGAAAAAAGAAATTGAAAGAACACAACAAAG
GATGAAAGAAATGGAGAGTGTTATGAAAGAGCAAGAACAGTACATTGCCACTCAGTACAAGGAGGCCATAGATTTGGGGCAAGAATTGAG
GCTGACCCGGGAGCAGGTGCAGAACTCTCATACAGAATTGGCAGAGGCTCGTCATCAGCAAGTCCAAGCACAGAGAGAAATAGAAAGGCT
CTCTAGTGAACTGGAGGATATGAAGCAACTCTCTAAAGAGAAAGATGCTCATGGAAACCATTTAGCTGAAGAACTGGGGGCTTCTAAAGT
ACGTGAAGCTCATTTAGAAGCAAGAATGCAAGCAGAAATCAAGAAATTGTCAGCAGAAGTAGAATCTCTCAAAGAAGCTTATCATATGGA
GATGATTTCACATCAAGAGAACCATGCAAAGTGGAAGATTTCTGCTGACTCTCAAAAGTCTTCTGTTCAGCAACTAAACGAACAGTTAGA
GAAGGCAAAATTGGAATTAGAAGAAGCTCAGGATACTGTAAGCAATTTGCATCAACAAGTCCAAGATAGGAATGAAGTAATTGAAGCTGC
AAATGAAGCATTACTTACTAAAGAATCAGAATTAACCAGATTACAGGCCAAAATTTCTGGACATGAAAAGGCAGAAGACATCAAGTTTCT
GCCAGCCCCATTTACATCTCCAACAGAAATTATGCCTGATGTTCAAGATCCAAAATTTGCTAAATGTTTTCACACATCTTTTTCCAAGTG
TACAAAATTACGTCGCTCTATTAGTGCCAGTGATCTTACTTTCAAAATTCATGGTGATGAAGATCTTTCTGAAGAATTACTACAGGACTT
AAAGAAAATGCAATTAGAACAGCCTTCAACATTAGAAGAAAGCCATAAGAATCTGACTTACACCCAGCCAGACTCATTTAAACCTCTCAC
ATATAACCTAGAAGCTGATAGTTCTGAGAATAATGACTTTAACACGCTTAGTGGGATGCTAAGATACATAAACAAAGAAGTAAGACTATT

>In-frame_ENST00000371730_ENST00000343253_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(amino acids)=1155AA_start in transcript=10_stop in transcript=3474
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS
LSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES
SKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE
SEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEK
KDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK
EKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK
MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQH
STETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWEL
KQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKE
MESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREA
HLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA
LLTKESELTRLQAKISGHEKAEDIKFLPAPFTSPTEIMPDVQDPKFAKCFHTSFSKCTKLRRSISASDLTFKIHGDEDLSEELLQDLKKM

--------------------------------------------------------------
>In-frame_ENST00000371730_ENST00000401026_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(transcript)=3140nt_BP=319nt
TGGAAACACCATGGCTGCGGCGGCCCAGCTCTCTCTGACACAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGA
TACAGGCAATACTGGAAGGGTGTTGGCTTCTGATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTG
GGATTTAGCCGACACAGATGGCAAAGGTATCCTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATT
GGAAGTTTCACTAAGTAGTTTGAACCTGGCTGTTCCTCCACCAAGATTTTTAAAAAGAGAATTATTTGGCTTTAAATCATATCTTTCTAA
ATACCAGATGAGTAGCTTCTCAAACAAGGAAGACCGTTGCATTGGCTGCTGTGAGGCAAATAAATTGGTGATTTCGGAATTGAGAATTAA
GCTTGCAATAAAAGAGGCAGAAATTCAAAAGCTTCATGCAAACCTGACTGCAAATCAGTTATCTCAGAGTCTTATTACTTGTAATGACAG
CCAAGAAAGTAGCAAATTAAGTAGTTTAGAAACAGAACCTGTAAAGCTAGGTGGTCATCAAGTAGCAGAAAGCGTAAAAGATCAAAATCA
ACATACTATGAACAAGCAATATGAAAAAGAGAGGCAAAGACTTGTTACTGGAATAGAAGAACTACGTACTAAGCTGATACAAATAGAAGC
TGAAAATTCTGATTTGAAGGTTAACATGGCTCACAGAACTAGTCAGTTTCAGCTGATTCAAGAGGAGCTGCTAGAGAAAGCTTCAAACTC
CAGCAAACTGGAAAGTGAAATGACAAAGAAATGTTCTCAACTTTTAACTCTTGAGAAACAGCTGGAAGAAAAGATAGTTGCTTATTCCTC
TATTGCTGCAAAAAATGCAGAACTAGAACAGGAGCTTATGGAAAAGAATGAAAAGATAAGGAGTCTAGAAACCAATATTAATACAGAGCA
TGAGAAAATTTGTTTAGCCTTTGAAAAAGCAAAGAAAATTCACTTGGAACAGCATAAAGAAATGGAAAAGCAGATTGAAAGACTTGAAGC
TCAACTAGAGAAAAAGGACCAACAATTTAAAGAACAAGAAAAGACTATGTCCATGTTGCAACAAGATATAATATGCAAACAACATCATCT
TGAATCACTAGATAGACTCTTGACGGAAAGCAAAGGGGAAATGAAAAAGGAAAATATGAAGAAAGATGAAGCTTTAAAAGCATTACAGAA
CCAAGTATCTGAAGAAACAATCAAGGTTAGGCAACTAGATTCAGCATTGGAAATTTGTAAGGAAGAACTTGTCTTGCATTTGAATCAATT
GGAAGGAAATAAGGAAAAGTTTGAAAAACAGTTAAAGAAGAAATCTGAAGAGGTATATTGTTTACAGAAAGAGCTAAAGATAAAAAATCA
CAGTCTTCAAGAGACTTCTGAGCAAAACGTTATTCTACAGCATACTCTTCAGCAACAGCAGCAAATGTTACAACAAGAGACAATTAGAAA
TGGAGAGCTAGAAGATACTCAAACTAAACTTGAAAAACAGGTGTCAAAACTGGAACAAGAACTTCAAAAACAAAGGGAAAGTTCAGCTGA
AAAGTTGAGAAAAATGGAGGAGAAATGTGAATCAGCTGCACATGAAGCAGATTTGAAAAGGCAAAAAGTGATTGAGCTTACTGGCACTGC
CAGGCAAGTAAAGATTGAGATGGATCAGTACAAAGAAGAGCTGTCTAAAATGGAAAAGGAAATAATGCACCTAAAACGAGATGGAGAAAA
TAAAGCAATGCACCTCTCTCAATTAGATATGATCTTAGATCAGACAAAGACAGAGCTAGAAAAGAAAACAAATGCTGTAAAGGAGTTAGA
AAAGTTACAGCACAGTACTGAAACTGAACTAACAGAAGCCTTGCAAAAACGGGAAGTACTTGAGACTGAACTACAAAATGCTCATGGAGA
ATTAAAAAGTACTTTAAGACAACTCCAGGAATTGAGAGATGTACTACAGAAGGCTCAATTATCATTAGAGGAAAAATACACTACTATAAA
GGATCTCACAGCTGAACTTAGAGAATGCAAGATGGAGATTGAAGACAAAAAGCAGGAGCTCCTTGAAATGGATCAGGCACTTAAAGAGAG
AAATTGGGAACTAAAGCAAAGAGCAGCTCAGGTTACACATTTGGATATGACTATTCGTGAGCACAGAGGAGAAATGGAACAAAAAATAAT
TAAATTAGAAGGTACTCTGGAGAAATCAGAATTGGAACTTAAAGAATGTAACAAACAGATAGAAAGTCTGAATGACAAATTACAAAATGC
TAAAGAACAGCTTCGAGAAAAAGAGTTTATAATGCTACAAAATGAACAGGAGATAAGTCAACTGAAAAAAGAAATTGAAAGAACACAACA
AAGGATGAAAGAAATGGAGAGTGTTATGAAAGAGCAAGAACAGTACATTGCCACTCAGTACAAGGAGGCCATAGATTTGGGGCAAGAATT
GAGGCTGACCCGGGAGCAGGTGCAGAACTCTCATACAGAATTGGCAGAGGCTCGTCATCAGCAAGTCCAAGCACAGAGAGAAATAGAAAG
GCTCTCTAGTGAACTGGAGGATATGAAGCAACTCTCTAAAGAGAAAGATGCTCATGGAAACCATTTAGCTGAAGAACTGGGGGCTTCTAA
AGTACGTGAAGCTCATTTAGAAGCAAGAATGCAAGCAGAAATCAAGAAATTGTCAGCAGAAGTAGAATCTCTCAAAGAAGCTTATCATAT
GGAGATGATTTCACATCAAGAGAACCATGCAAAGTGGAAGATTTCTGCTGACTCTCAAAAGTCTTCTGTTCAGCAACTAAACGAACAGTT
AGAGAAGGCAAAATTGGAATTAGAAGAAGCTCAGGATACTGTAAGCAATTTGCATCAACAAGTCCAAGATAGGAATGAAGTAATTGAAGC
TGCAAATGAAGCATTACTTACTAAAGGAGAAAATGTGTAATTCAAAGAAGATACTGATGTGTTGAAAAAATGGAATTTTTGGTACTGTGC

>In-frame_ENST00000371730_ENST00000401026_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(amino acids)=999AA_start in transcript=10_stop in transcript=3009
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS
LSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES
SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKL
ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLE
KKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN
KEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLR
KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQ
HSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWE
LKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMK
EMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE
AHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANE

--------------------------------------------------------------
>In-frame_ENST00000371730_ENST00000338949_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(transcript)=3114nt_BP=319nt
TGGAAACACCATGGCTGCGGCGGCCCAGCTCTCTCTGACACAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGA
TACAGGCAATACTGGAAGGGTGTTGGCTTCTGATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTG
GGATTTAGCCGACACAGATGGCAAAGGTATCCTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATT
GGAAGTTTCACTAAGTAGTTTGAACCTGGCTGTTCCTCCACCAAGATTTTTAAAAAGAGAATTATTTGGCTTTAAATCATATCTTTCTAA
ATACCAGATGAGTAGCTTCTCAAACAAGGAAGACCGTTGCATTGGCTGCTGTGAGGCAAATAAATTGGTGATTTCGGAATTGAGAATTAA
GCTTGCAATAAAAGAGGCAGAAATTCAAAAGCTTCATGCAAACCTGACTGCAAATCAGTTATCTCAGAGTCTTATTACTTGTAATGACAG
CCAAGAAAGTAGCAAATTAAGTAGTTTAGAAACAGAACCTGTAAAGCTAGGTGGTCATCAAGTAGCAGAAAGCGTAAAAGATCAAAATCA
ACATACTATGAACAAGCAATATGAAAAAGAGAGGCAAAGACTTGTTACTGGAATAGAAGAACTACGTACTAAGCTGATACAAATAGAAGC
TGAAAATTCTGATTTGAAGGTTAACATGGCTCACAGAACTAGTCAGTTTCAGCTGATTCAAGAGGAGCTGCTAGAGAAAGCTTCAAACTC
CAGCAAACTGGAAAGTGAAATGACAAAGAAATGTTCTCAACTTTTAACTCTTGAGAAACAGCTGGAAGAAAAGATAGTTGCTTATTCCTC
TATTGCTGCAAAAAATGCAGAACTAGAACAGGAGCTTATGCTTGAAGCTCAACTAGAGAAAAAGGACCAACAATTTAAAGAACAAGAAAA
GACTATGTCCATGTTGCAACAAGATATAATATGCAAACAACATCATCTTGAATCACTAGATAGACTCTTGACGGAAAGCAAAGGGGAAAT
GAAAAAGGAAAATATGAAGAAAGATGAAGCTTTAAAAGCATTACAGAACCAAGTATCTGAAGAAACAATCAAGGTTAGGCAACTAGATTC
AGCATTGGAAATTTGTAAGGAAGAACTTGTCTTGCATTTGAATCAATTGGAAGGAAATAAGGAAAAGTTTGAAAAACAGTTAAAGAAGAA
ATCTGAAGAGGTATATTGTTTACAGAAAGAGCTAAAGATAAAAAATCACAGTCTTCAAGAGACTTCTGAGCAAAACGTTATTCTACAGCA
TACTCTTCAGCAACAGCAGCAAATGTTACAACAAGAGACAATTAGAAATGGAGAGCTAGAAGATACTCAAACTAAACTTGAAAAACAGGT
GTCAAAACTGGAACAAGAACTTCAAAAACAAAGGGAAAGTTCAGCTGAAAAGTTGAGAAAAATGGAGGAGAAATGTGAATCAGCTGCACA
TGAAGCAGATTTGAAAAGGCAAAAAGTGATTGAGCTTACTGGCACTGCCAGGCAAGTAAAGATTGAGATGGATCAGTACAAAGAAGAGCT
GTCTAAAATGGAAAAGGAAATAATGCACCTAAAACGAGATGGAGAAAATAAAGCAATGCACCTCTCTCAATTAGATATGATCTTAGATCA
GACAAAGACAGAGCTAGAAAAGAAAACAAATGCTGTAAAGGAGTTAGAAAAGTTACAGCACAGTACTGAAACTGAACTAACAGAAGCCTT
GCAAAAACGGGAAGTACTTGAGACTGAACTACAAAATGCTCATGGAGAATTAAAAAGTACTTTAAGACAACTCCAGGAATTGAGAGATGT
ACTACAGAAGGCTCAATTATCATTAGAGGAAAAATACACTACTATAAAGGATCTCACAGCTGAACTTAGAGAATGCAAGATGGAGATTGA
AGACAAAAAGCAGGAGCTCCTTGAAATGGATCAGGCACTTAAAGAGAGAAATTGGGAACTAAAGCAAAGAGCAGCTCAGGTTACACATTT
GGATATGACTATTCGTGAGCACAGAGGAGAAATGGAACAAAAAATAATTAAATTAGAAGGTACTCTGGAGAAATCAGAATTGGAACTTAA
AGAATGTAACAAACAGATAGAAAGTCTGAATGACAAATTACAAAATGCTAAAGAACAGCTTCGAGAAAAAGAGTTTATAATGCTACAAAA
TGAACAGGAGATAAGTCAACTGAAAAAAGAAATTGAAAGAACACAACAAAGGATGAAAGAAATGGAGAGTGTTATGAAAGAGCAAGAACA
GTACATTGCCACTCAGTACAAGGAGGCCATAGATTTGGGGCAAGAATTGAGGCTGACCCGGGAGCAGGTGCAGAACTCTCATACAGAATT
GGCAGAGGCTCGTCATCAGCAAGTCCAAGCACAGAGAGAAATAGAAAGGCTCTCTAGTGAACTGGAGGATATGAAGCAACTCTCTAAAGA
GAAAGATGCTCATGGAAACCATTTAGCTGAAGAACTGGGGGCTTCTAAAGTACGTGAAGCTCATTTAGAAGCAAGAATGCAAGCAGAAAT
CAAGAAATTGTCAGCAGAAGTAGAATCTCTCAAAGAAGCTTATCATATGGAGATGATTTCACATCAAGAGAACCATGCAAAGTGGAAGAT
TTCTGCTGACTCTCAAAAGTCTTCTGTTCAGCAACTAAACGAACAGTTAGAGAAGGCAAAATTGGAATTAGAAGAAGCTCAGGATACTGT
AAGCAATTTGCATCAACAAGTCCAAGATAGGAATGAAGTAATTGAAGCTGCAAATGAAGCATTACTTACTAAAGGAGAAAATGTGTAATT
CAAAGAAGATACTGATGTGTTGAAAAAATGGAATTTTTGGTACTGTGCTGTTTACTTATTATATGTAGCTCATACTTCATAGAAGCTGTT
ATTTTGCTTTTGAATAAATTTTATATTTCAATATTTTAAAAGAAAGCCCTTCTAAAACTTAATTATATTTTTAAAGAAAATTTATTATTT

>In-frame_ENST00000371730_ENST00000338949_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(amino acids)=955AA_start in transcript=10_stop in transcript=2877
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS
LSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES
SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKL
ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKE
NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQ
QQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKM
EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQK
AQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN
KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEA
RHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISAD

--------------------------------------------------------------
>In-frame_ENST00000371733_ENST00000343253_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(transcript)=3562nt_BP=406nt
GCCCCGGCCTCGCCTGCGGCCGCTCCCTCCGCCTCCTCCCCGCCCCGAGCCCCAGTCAGCCCGTCTTCCTTCCCCTCCCTTGCATGATGG
AAACACCATGGCTGCGGCGGCCCAGCTCTCTCTGACACAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGATAC
AGGCAATACTGGAAGGGTGTTGGCTTCTGATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTGGGA
TTTAGCCGACACAGATGGCAAAGGTATCCTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATTGGA
AGTTTCACTAAGTAGTTTGAACCTGGCTGTTCCTCCACCAAGATTTTTAAAAAGAGAATTATTTGGCTTTAAATCATATCTTTCTAAATA
CCAGATGAGTAGCTTCTCAAACAAGGAAGACCGTTGCATTGGCTGCTGTGAGGCAAATAAATTGGTGATTTCGGAATTGAGAATTAAGCT
TGCAATAAAAGAGGCAGAAATTCAAAAGCTTCATGCAAACCTGACTGCAAATCAGTTATCTCAGAGTCTTATTACTTGTAATGACAGCCA
AGAAAGTAGCAAATTAAGTAGTTTAGAAACAGAACCTGTAAAGCTAGGTGGTCATCAAGTAGAAAGCGTAAAAGATCAAAATCAACATAC
TATGAACAAGCAATATGAAAAAGAGAGGCAAAGACTTGTTACTGGAATAGAAGAACTACGTACTAAGCTGATACAAATAGAAGCTGAAAA
TTCTGATTTGAAGGTTAACATGGCTCACAGAACTAGTCAGTTTCAGCTGATTCAAGAGGAGCTGCTAGAGAAAGCTTCAAACTCCAGCAA
ACTGGAAAGTGAAATGACAAAGAAATGTTCTCAACTTTTAACTCTTGAGAAACAGCTGGAAGAAAAGATAGTTGCTTATTCCTCTATTGC
TGCAAAAAATGCAGAACTAGAACAGGAGCTTATGGAAAAGAATGAAAAGATAAGGAGTCTAGAAACCAATATTAATACAGAGCATGAGAA
AATTTGTTTAGCCTTTGAAAAAGCAAAGAAAATTCACTTGGAACAGCATAAAGAAATGGAAAAGCAGATTGAAAGACTTGAAGCTCAACT
AGAGAAAAAGGACCAACAATTTAAAGAACAAGAAAAGACTATGTCCATGTTGCAACAAGATATAATATGCAAACAACATCATCTTGAATC
ACTAGATAGACTCTTGACGGAAAGCAAAGGGGAAATGAAAAAGGAAAATATGAAGAAAGATGAAGCTTTAAAAGCATTACAGAACCAAGT
ATCTGAAGAAACAATCAAGGTTAGGCAACTAGATTCAGCATTGGAAATTTGTAAGGAAGAACTTGTCTTGCATTTGAATCAATTGGAAGG
AAATAAGGAAAAGTTTGAAAAACAGTTAAAGAAGAAATCTGAAGAGGTATATTGTTTACAGAAAGAGCTAAAGATAAAAAATCACAGTCT
TCAAGAGACTTCTGAGCAAAACGTTATTCTACAGCATACTCTTCAGCAACAGCAGCAAATGTTACAACAAGAGACAATTAGAAATGGAGA
GCTAGAAGATACTCAAACTAAACTTGAAAAACAGGTGTCAAAACTGGAACAAGAACTTCAAAAACAAAGGGAAAGTTCAGCTGAAAAGTT
GAGAAAAATGGAGGAGAAATGTGAATCAGCTGCACATGAAGCAGATTTGAAAAGGCAAAAAGTGATTGAGCTTACTGGCACTGCCAGGCA
AGTAAAGATTGAGATGGATCAGTACAAAGAAGAGCTGTCTAAAATGGAAAAGGAAATAATGCACCTAAAACGAGATGGAGAAAATAAAGC
AATGCACCTCTCTCAATTAGATATGATCTTAGATCAGACAAAGACAGAGCTAGAAAAGAAAACAAATGCTGTAAAGGAGTTAGAAAAGTT
ACAGCACAGTACTGAAACTGAACTAACAGAAGCCTTGCAAAAACGGGAAGTACTTGAGACTGAACTACAAAATGCTCATGGAGAATTAAA
AAGTACTTTAAGACAACTCCAGGAATTGAGAGATGTACTACAGAAGGCTCAATTATCATTAGAGGAAAAATACACTACTATAAAGGATCT
CACAGCTGAACTTAGAGAATGCAAGATGGAGATTGAAGACAAAAAGCAGGAGCTCCTTGAAATGGATCAGGCACTTAAAGAGAGAAATTG
GGAACTAAAGCAAAGAGCAGCTCAGGTTACACATTTGGATATGACTATTCGTGAGCACAGAGGAGAAATGGAACAAAAAATAATTAAATT
AGAAGGTACTCTGGAGAAATCAGAATTGGAACTTAAAGAATGTAACAAACAGATAGAAAGTCTGAATGACAAATTACAAAATGCTAAAGA
ACAGCTTCGAGAAAAAGAGTTTATAATGCTACAAAATGAACAGGAGATAAGTCAACTGAAAAAAGAAATTGAAAGAACACAACAAAGGAT
GAAAGAAATGGAGAGTGTTATGAAAGAGCAAGAACAGTACATTGCCACTCAGTACAAGGAGGCCATAGATTTGGGGCAAGAATTGAGGCT
GACCCGGGAGCAGGTGCAGAACTCTCATACAGAATTGGCAGAGGCTCGTCATCAGCAAGTCCAAGCACAGAGAGAAATAGAAAGGCTCTC
TAGTGAACTGGAGGATATGAAGCAACTCTCTAAAGAGAAAGATGCTCATGGAAACCATTTAGCTGAAGAACTGGGGGCTTCTAAAGTACG
TGAAGCTCATTTAGAAGCAAGAATGCAAGCAGAAATCAAGAAATTGTCAGCAGAAGTAGAATCTCTCAAAGAAGCTTATCATATGGAGAT
GATTTCACATCAAGAGAACCATGCAAAGTGGAAGATTTCTGCTGACTCTCAAAAGTCTTCTGTTCAGCAACTAAACGAACAGTTAGAGAA
GGCAAAATTGGAATTAGAAGAAGCTCAGGATACTGTAAGCAATTTGCATCAACAAGTCCAAGATAGGAATGAAGTAATTGAAGCTGCAAA
TGAAGCATTACTTACTAAAGAATCAGAATTAACCAGATTACAGGCCAAAATTTCTGGACATGAAAAGGCAGAAGACATCAAGTTTCTGCC
AGCCCCATTTACATCTCCAACAGAAATTATGCCTGATGTTCAAGATCCAAAATTTGCTAAATGTTTTCACACATCTTTTTCCAAGTGTAC
AAAATTACGTCGCTCTATTAGTGCCAGTGATCTTACTTTCAAAATTCATGGTGATGAAGATCTTTCTGAAGAATTACTACAGGACTTAAA
GAAAATGCAATTAGAACAGCCTTCAACATTAGAAGAAAGCCATAAGAATCTGACTTACACCCAGCCAGACTCATTTAAACCTCTCACATA
TAACCTAGAAGCTGATAGTTCTGAGAATAATGACTTTAACACGCTTAGTGGGATGCTAAGATACATAAACAAAGAAGTAAGACTATTAAA

>In-frame_ENST00000371733_ENST00000343253_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(amino acids)=1183AA_start in transcript=13_stop in transcript=3561
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADT
DGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE
AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLK
VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLA
FEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEET
IKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDT
QTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLS
QLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAEL
RECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLRE
KEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELE
DMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLE
LEEAQDTVSNLHQQVQDRNEVIEAANEALLTKESELTRLQAKISGHEKAEDIKFLPAPFTSPTEIMPDVQDPKFAKCFHTSFSKCTKLRR
SISASDLTFKIHGDEDLSEELLQDLKKMQLEQPSTLEESHKNLTYTQPDSFKPLTYNLEADSSENNDFNTLSGMLRYINKEVRLLKKSSM

--------------------------------------------------------------
>In-frame_ENST00000371733_ENST00000401026_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(transcript)=3227nt_BP=406nt
GCCCCGGCCTCGCCTGCGGCCGCTCCCTCCGCCTCCTCCCCGCCCCGAGCCCCAGTCAGCCCGTCTTCCTTCCCCTCCCTTGCATGATGG
AAACACCATGGCTGCGGCGGCCCAGCTCTCTCTGACACAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGATAC
AGGCAATACTGGAAGGGTGTTGGCTTCTGATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTGGGA
TTTAGCCGACACAGATGGCAAAGGTATCCTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATTGGA
AGTTTCACTAAGTAGTTTGAACCTGGCTGTTCCTCCACCAAGATTTTTAAAAAGAGAATTATTTGGCTTTAAATCATATCTTTCTAAATA
CCAGATGAGTAGCTTCTCAAACAAGGAAGACCGTTGCATTGGCTGCTGTGAGGCAAATAAATTGGTGATTTCGGAATTGAGAATTAAGCT
TGCAATAAAAGAGGCAGAAATTCAAAAGCTTCATGCAAACCTGACTGCAAATCAGTTATCTCAGAGTCTTATTACTTGTAATGACAGCCA
AGAAAGTAGCAAATTAAGTAGTTTAGAAACAGAACCTGTAAAGCTAGGTGGTCATCAAGTAGCAGAAAGCGTAAAAGATCAAAATCAACA
TACTATGAACAAGCAATATGAAAAAGAGAGGCAAAGACTTGTTACTGGAATAGAAGAACTACGTACTAAGCTGATACAAATAGAAGCTGA
AAATTCTGATTTGAAGGTTAACATGGCTCACAGAACTAGTCAGTTTCAGCTGATTCAAGAGGAGCTGCTAGAGAAAGCTTCAAACTCCAG
CAAACTGGAAAGTGAAATGACAAAGAAATGTTCTCAACTTTTAACTCTTGAGAAACAGCTGGAAGAAAAGATAGTTGCTTATTCCTCTAT
TGCTGCAAAAAATGCAGAACTAGAACAGGAGCTTATGGAAAAGAATGAAAAGATAAGGAGTCTAGAAACCAATATTAATACAGAGCATGA
GAAAATTTGTTTAGCCTTTGAAAAAGCAAAGAAAATTCACTTGGAACAGCATAAAGAAATGGAAAAGCAGATTGAAAGACTTGAAGCTCA
ACTAGAGAAAAAGGACCAACAATTTAAAGAACAAGAAAAGACTATGTCCATGTTGCAACAAGATATAATATGCAAACAACATCATCTTGA
ATCACTAGATAGACTCTTGACGGAAAGCAAAGGGGAAATGAAAAAGGAAAATATGAAGAAAGATGAAGCTTTAAAAGCATTACAGAACCA
AGTATCTGAAGAAACAATCAAGGTTAGGCAACTAGATTCAGCATTGGAAATTTGTAAGGAAGAACTTGTCTTGCATTTGAATCAATTGGA
AGGAAATAAGGAAAAGTTTGAAAAACAGTTAAAGAAGAAATCTGAAGAGGTATATTGTTTACAGAAAGAGCTAAAGATAAAAAATCACAG
TCTTCAAGAGACTTCTGAGCAAAACGTTATTCTACAGCATACTCTTCAGCAACAGCAGCAAATGTTACAACAAGAGACAATTAGAAATGG
AGAGCTAGAAGATACTCAAACTAAACTTGAAAAACAGGTGTCAAAACTGGAACAAGAACTTCAAAAACAAAGGGAAAGTTCAGCTGAAAA
GTTGAGAAAAATGGAGGAGAAATGTGAATCAGCTGCACATGAAGCAGATTTGAAAAGGCAAAAAGTGATTGAGCTTACTGGCACTGCCAG
GCAAGTAAAGATTGAGATGGATCAGTACAAAGAAGAGCTGTCTAAAATGGAAAAGGAAATAATGCACCTAAAACGAGATGGAGAAAATAA
AGCAATGCACCTCTCTCAATTAGATATGATCTTAGATCAGACAAAGACAGAGCTAGAAAAGAAAACAAATGCTGTAAAGGAGTTAGAAAA
GTTACAGCACAGTACTGAAACTGAACTAACAGAAGCCTTGCAAAAACGGGAAGTACTTGAGACTGAACTACAAAATGCTCATGGAGAATT
AAAAAGTACTTTAAGACAACTCCAGGAATTGAGAGATGTACTACAGAAGGCTCAATTATCATTAGAGGAAAAATACACTACTATAAAGGA
TCTCACAGCTGAACTTAGAGAATGCAAGATGGAGATTGAAGACAAAAAGCAGGAGCTCCTTGAAATGGATCAGGCACTTAAAGAGAGAAA
TTGGGAACTAAAGCAAAGAGCAGCTCAGGTTACACATTTGGATATGACTATTCGTGAGCACAGAGGAGAAATGGAACAAAAAATAATTAA
ATTAGAAGGTACTCTGGAGAAATCAGAATTGGAACTTAAAGAATGTAACAAACAGATAGAAAGTCTGAATGACAAATTACAAAATGCTAA
AGAACAGCTTCGAGAAAAAGAGTTTATAATGCTACAAAATGAACAGGAGATAAGTCAACTGAAAAAAGAAATTGAAAGAACACAACAAAG
GATGAAAGAAATGGAGAGTGTTATGAAAGAGCAAGAACAGTACATTGCCACTCAGTACAAGGAGGCCATAGATTTGGGGCAAGAATTGAG
GCTGACCCGGGAGCAGGTGCAGAACTCTCATACAGAATTGGCAGAGGCTCGTCATCAGCAAGTCCAAGCACAGAGAGAAATAGAAAGGCT
CTCTAGTGAACTGGAGGATATGAAGCAACTCTCTAAAGAGAAAGATGCTCATGGAAACCATTTAGCTGAAGAACTGGGGGCTTCTAAAGT
ACGTGAAGCTCATTTAGAAGCAAGAATGCAAGCAGAAATCAAGAAATTGTCAGCAGAAGTAGAATCTCTCAAAGAAGCTTATCATATGGA
GATGATTTCACATCAAGAGAACCATGCAAAGTGGAAGATTTCTGCTGACTCTCAAAAGTCTTCTGTTCAGCAACTAAACGAACAGTTAGA
GAAGGCAAAATTGGAATTAGAAGAAGCTCAGGATACTGTAAGCAATTTGCATCAACAAGTCCAAGATAGGAATGAAGTAATTGAAGCTGC
AAATGAAGCATTACTTACTAAAGGAGAAAATGTGTAATTCAAAGAAGATACTGATGTGTTGAAAAAATGGAATTTTTGGTACTGTGCTGT

>In-frame_ENST00000371733_ENST00000401026_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(amino acids)=1027AA_start in transcript=13_stop in transcript=3096
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADT
DGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE
AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDL
KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL
AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEE
TIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELED
TQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL
SQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAE
LRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLR
EKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL
EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKL

--------------------------------------------------------------
>In-frame_ENST00000371733_ENST00000338949_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(transcript)=3201nt_BP=406nt
GCCCCGGCCTCGCCTGCGGCCGCTCCCTCCGCCTCCTCCCCGCCCCGAGCCCCAGTCAGCCCGTCTTCCTTCCCCTCCCTTGCATGATGG
AAACACCATGGCTGCGGCGGCCCAGCTCTCTCTGACACAGTTATCAAGTGGGAATCCTGTATATGAAAAATACTATAGACAGGTTGATAC
AGGCAATACTGGAAGGGTGTTGGCTTCTGATGCTGCTGCTTTCCTGAAAAAATCAGGGCTTCCAGACTTGATACTTGGAAAGATTTGGGA
TTTAGCCGACACAGATGGCAAAGGTATCCTGAACAAACAAGAATTCTTTGTTGCTTTGCGTCTTGTGGCATGTGCCCAGAATGGATTGGA
AGTTTCACTAAGTAGTTTGAACCTGGCTGTTCCTCCACCAAGATTTTTAAAAAGAGAATTATTTGGCTTTAAATCATATCTTTCTAAATA
CCAGATGAGTAGCTTCTCAAACAAGGAAGACCGTTGCATTGGCTGCTGTGAGGCAAATAAATTGGTGATTTCGGAATTGAGAATTAAGCT
TGCAATAAAAGAGGCAGAAATTCAAAAGCTTCATGCAAACCTGACTGCAAATCAGTTATCTCAGAGTCTTATTACTTGTAATGACAGCCA
AGAAAGTAGCAAATTAAGTAGTTTAGAAACAGAACCTGTAAAGCTAGGTGGTCATCAAGTAGCAGAAAGCGTAAAAGATCAAAATCAACA
TACTATGAACAAGCAATATGAAAAAGAGAGGCAAAGACTTGTTACTGGAATAGAAGAACTACGTACTAAGCTGATACAAATAGAAGCTGA
AAATTCTGATTTGAAGGTTAACATGGCTCACAGAACTAGTCAGTTTCAGCTGATTCAAGAGGAGCTGCTAGAGAAAGCTTCAAACTCCAG
CAAACTGGAAAGTGAAATGACAAAGAAATGTTCTCAACTTTTAACTCTTGAGAAACAGCTGGAAGAAAAGATAGTTGCTTATTCCTCTAT
TGCTGCAAAAAATGCAGAACTAGAACAGGAGCTTATGCTTGAAGCTCAACTAGAGAAAAAGGACCAACAATTTAAAGAACAAGAAAAGAC
TATGTCCATGTTGCAACAAGATATAATATGCAAACAACATCATCTTGAATCACTAGATAGACTCTTGACGGAAAGCAAAGGGGAAATGAA
AAAGGAAAATATGAAGAAAGATGAAGCTTTAAAAGCATTACAGAACCAAGTATCTGAAGAAACAATCAAGGTTAGGCAACTAGATTCAGC
ATTGGAAATTTGTAAGGAAGAACTTGTCTTGCATTTGAATCAATTGGAAGGAAATAAGGAAAAGTTTGAAAAACAGTTAAAGAAGAAATC
TGAAGAGGTATATTGTTTACAGAAAGAGCTAAAGATAAAAAATCACAGTCTTCAAGAGACTTCTGAGCAAAACGTTATTCTACAGCATAC
TCTTCAGCAACAGCAGCAAATGTTACAACAAGAGACAATTAGAAATGGAGAGCTAGAAGATACTCAAACTAAACTTGAAAAACAGGTGTC
AAAACTGGAACAAGAACTTCAAAAACAAAGGGAAAGTTCAGCTGAAAAGTTGAGAAAAATGGAGGAGAAATGTGAATCAGCTGCACATGA
AGCAGATTTGAAAAGGCAAAAAGTGATTGAGCTTACTGGCACTGCCAGGCAAGTAAAGATTGAGATGGATCAGTACAAAGAAGAGCTGTC
TAAAATGGAAAAGGAAATAATGCACCTAAAACGAGATGGAGAAAATAAAGCAATGCACCTCTCTCAATTAGATATGATCTTAGATCAGAC
AAAGACAGAGCTAGAAAAGAAAACAAATGCTGTAAAGGAGTTAGAAAAGTTACAGCACAGTACTGAAACTGAACTAACAGAAGCCTTGCA
AAAACGGGAAGTACTTGAGACTGAACTACAAAATGCTCATGGAGAATTAAAAAGTACTTTAAGACAACTCCAGGAATTGAGAGATGTACT
ACAGAAGGCTCAATTATCATTAGAGGAAAAATACACTACTATAAAGGATCTCACAGCTGAACTTAGAGAATGCAAGATGGAGATTGAAGA
CAAAAAGCAGGAGCTCCTTGAAATGGATCAGGCACTTAAAGAGAGAAATTGGGAACTAAAGCAAAGAGCAGCTCAGGTTACACATTTGGA
TATGACTATTCGTGAGCACAGAGGAGAAATGGAACAAAAAATAATTAAATTAGAAGGTACTCTGGAGAAATCAGAATTGGAACTTAAAGA
ATGTAACAAACAGATAGAAAGTCTGAATGACAAATTACAAAATGCTAAAGAACAGCTTCGAGAAAAAGAGTTTATAATGCTACAAAATGA
ACAGGAGATAAGTCAACTGAAAAAAGAAATTGAAAGAACACAACAAAGGATGAAAGAAATGGAGAGTGTTATGAAAGAGCAAGAACAGTA
CATTGCCACTCAGTACAAGGAGGCCATAGATTTGGGGCAAGAATTGAGGCTGACCCGGGAGCAGGTGCAGAACTCTCATACAGAATTGGC
AGAGGCTCGTCATCAGCAAGTCCAAGCACAGAGAGAAATAGAAAGGCTCTCTAGTGAACTGGAGGATATGAAGCAACTCTCTAAAGAGAA
AGATGCTCATGGAAACCATTTAGCTGAAGAACTGGGGGCTTCTAAAGTACGTGAAGCTCATTTAGAAGCAAGAATGCAAGCAGAAATCAA
GAAATTGTCAGCAGAAGTAGAATCTCTCAAAGAAGCTTATCATATGGAGATGATTTCACATCAAGAGAACCATGCAAAGTGGAAGATTTC
TGCTGACTCTCAAAAGTCTTCTGTTCAGCAACTAAACGAACAGTTAGAGAAGGCAAAATTGGAATTAGAAGAAGCTCAGGATACTGTAAG
CAATTTGCATCAACAAGTCCAAGATAGGAATGAAGTAATTGAAGCTGCAAATGAAGCATTACTTACTAAAGGAGAAAATGTGTAATTCAA
AGAAGATACTGATGTGTTGAAAAAATGGAATTTTTGGTACTGTGCTGTTTACTTATTATATGTAGCTCATACTTCATAGAAGCTGTTATT
TTGCTTTTGAATAAATTTTATATTTCAATATTTTAAAAGAAAGCCCTTCTAAAACTTAATTATATTTTTAAAGAAAATTTATTATTTTAT

>In-frame_ENST00000371733_ENST00000338949_TCGA-UY-A78N-01A_EPS15_chr1_51934145_-_CCDC18_chr1_93676359_length(amino acids)=983AA_start in transcript=13_stop in transcript=2964
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADT
DGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE
AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDL
KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMLEAQLEKKDQQFKEQEKTMSML
QQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY
CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLK
RQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREV
LETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIR
EHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ
YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EPS15-CCDC18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEPS15chr1:51934145chr1:93676359ENST00000371733-5252_330103.0897.0DAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EPS15-CCDC18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EPS15-CCDC18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource