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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EPS15L1-SLC15A5 (FusionGDB2 ID:27052)

Fusion Gene Summary for EPS15L1-SLC15A5

check button Fusion gene summary
Fusion gene informationFusion gene name: EPS15L1-SLC15A5
Fusion gene ID: 27052
HgeneTgene
Gene symbol

EPS15L1

SLC15A5

Gene ID

58513

729025

Gene nameepidermal growth factor receptor pathway substrate 15 like 1solute carrier family 15 member 5
SynonymsEPS15R-
Cytomap

19p13.11

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionepidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15Reps15-related proteinsolute carrier family 15 member 5Peptide/histidine transporter ENSP00000340402
Modification date2020031320200313
UniProtAcc

Q9UBC2

.
Ensembl transtripts involved in fusion geneENST00000455140, ENST00000248070, 
ENST00000535753, ENST00000594975, 
ENST00000602009, ENST00000597937, 
ENST00000344941, 
Fusion gene scores* DoF score23 X 17 X 14=54741 X 1 X 1=1
# samples 341
** MAII scorelog2(34/5474*10)=-4.00898878322726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: EPS15L1 [Title/Abstract] AND SLC15A5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEPS15L1(16495939)-SLC15A5(16392801), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EPS15L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC15A5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1023EPS15L1chr19

16495939

-SLC15A5chr12

16392801

-


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Fusion Gene ORF analysis for EPS15L1-SLC15A5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000455140ENST00000344941EPS15L1chr19

16495939

-SLC15A5chr12

16392801

-
In-frameENST00000248070ENST00000344941EPS15L1chr19

16495939

-SLC15A5chr12

16392801

-
In-frameENST00000535753ENST00000344941EPS15L1chr19

16495939

-SLC15A5chr12

16392801

-
In-frameENST00000594975ENST00000344941EPS15L1chr19

16495939

-SLC15A5chr12

16392801

-
intron-3CDSENST00000602009ENST00000344941EPS15L1chr19

16495939

-SLC15A5chr12

16392801

-
intron-3CDSENST00000597937ENST00000344941EPS15L1chr19

16495939

-SLC15A5chr12

16392801

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000455140EPS15L1chr1916495939-ENST00000344941SLC15A5chr1216392801-426223146730781003
ENST00000248070EPS15L1chr1916495939-ENST00000344941SLC15A5chr1216392801-43352387231511049
ENST00000535753EPS15L1chr1916495939-ENST00000344941SLC15A5chr1216392801-422622783130421003
ENST00000594975EPS15L1chr1916495939-ENST00000344941SLC15A5chr1216392801-43412393231571051

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000455140ENST00000344941EPS15L1chr1916495939-SLC15A5chr1216392801-0.0012409110.99875915
ENST00000248070ENST00000344941EPS15L1chr1916495939-SLC15A5chr1216392801-0.0011446780.99885535
ENST00000535753ENST00000344941EPS15L1chr1916495939-SLC15A5chr1216392801-0.0011512360.9988488
ENST00000594975ENST00000344941EPS15L1chr1916495939-SLC15A5chr1216392801-0.0005451340.9994549

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Fusion Genomic Features for EPS15L1-SLC15A5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EPS15L1-SLC15A5


check button Go to

FGviewer for the breakpoints of chr19:16495939-chr12:16392801

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPS15L1

Q9UBC2

.
FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123172_184749.0865.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124172_184749.0911.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122172_184749.0755.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123386_553749.0865.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124386_553749.0911.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122386_553749.0755.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123127_215749.0865.0DomainEH 2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123159_194749.0865.0DomainEF-hand
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-212315_104749.0865.0DomainEH 1
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123275_365749.0865.0DomainEH 3
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124127_215749.0911.0DomainEH 2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124159_194749.0911.0DomainEF-hand
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-212415_104749.0911.0DomainEH 1
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124275_365749.0911.0DomainEH 3
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122127_215749.0755.0DomainEH 2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122159_194749.0755.0DomainEF-hand
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-212215_104749.0755.0DomainEH 1
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122275_365749.0755.0DomainEH 3
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123618_620749.0865.0RepeatNote=1
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123640_642749.0865.0RepeatNote=2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123645_647749.0865.0RepeatNote=3
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123650_652749.0865.0RepeatNote=4
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123656_658749.0865.0RepeatNote=5
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123661_663749.0865.0RepeatNote=6
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123667_669749.0865.0RepeatNote=7
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123685_687749.0865.0RepeatNote=8
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123690_692749.0865.0RepeatNote=9
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123709_711749.0865.0RepeatNote=10
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123728_730749.0865.0RepeatNote=11
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124618_620749.0911.0RepeatNote=1
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124640_642749.0911.0RepeatNote=2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124645_647749.0911.0RepeatNote=3
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124650_652749.0911.0RepeatNote=4
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124656_658749.0911.0RepeatNote=5
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124661_663749.0911.0RepeatNote=6
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124667_669749.0911.0RepeatNote=7
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124685_687749.0911.0RepeatNote=8
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124690_692749.0911.0RepeatNote=9
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124709_711749.0911.0RepeatNote=10
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124728_730749.0911.0RepeatNote=11
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122618_620749.0755.0RepeatNote=1
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122640_642749.0755.0RepeatNote=2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122645_647749.0755.0RepeatNote=3
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122650_652749.0755.0RepeatNote=4
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122656_658749.0755.0RepeatNote=5
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122661_663749.0755.0RepeatNote=6
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122667_669749.0755.0RepeatNote=7
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122685_687749.0755.0RepeatNote=8
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122690_692749.0755.0RepeatNote=9
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122709_711749.0755.0RepeatNote=10
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122728_730749.0755.0RepeatNote=11
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139343_363325.0580.0TransmembraneHelical
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139386_406325.0580.0TransmembraneHelical
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139422_442325.0580.0TransmembraneHelical
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139472_492325.0580.0TransmembraneHelical
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139509_529325.0580.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116172_1840602.0Calcium bindingOntology_term=ECO:0000255
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116386_5530602.0Coiled coilOntology_term=ECO:0000255
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123750_816749.0865.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124750_816749.0911.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122750_816749.0755.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116750_8160602.0Compositional biasNote=Pro-rich
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116127_2150602.0DomainEH 2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116159_1940602.0DomainEF-hand
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-11615_1040602.0DomainEH 1
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116275_3650602.0DomainEH 3
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123618_835749.0865.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124618_835749.0911.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122618_835749.0755.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116618_8350602.0RegionNote=15 X 3 AA repeats of D-P-F
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123754_756749.0865.0RepeatNote=12
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123806_808749.0865.0RepeatNote=13
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123812_814749.0865.0RepeatNote=14
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-2123833_835749.0865.0RepeatNote=15
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124754_756749.0911.0RepeatNote=12
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124806_808749.0911.0RepeatNote=13
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124812_814749.0911.0RepeatNote=14
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-2124833_835749.0911.0RepeatNote=15
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122754_756749.0755.0RepeatNote=12
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122806_808749.0755.0RepeatNote=13
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122812_814749.0755.0RepeatNote=14
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-2122833_835749.0755.0RepeatNote=15
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116618_6200602.0RepeatNote=1
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116640_6420602.0RepeatNote=2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116645_6470602.0RepeatNote=3
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116650_6520602.0RepeatNote=4
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116656_6580602.0RepeatNote=5
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116661_6630602.0RepeatNote=6
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116667_6690602.0RepeatNote=7
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116685_6870602.0RepeatNote=8
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116690_6920602.0RepeatNote=9
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116709_7110602.0RepeatNote=10
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116728_7300602.0RepeatNote=11
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116754_7560602.0RepeatNote=12
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116806_8080602.0RepeatNote=13
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116812_8140602.0RepeatNote=14
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-116833_8350602.0RepeatNote=15
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139110_130325.0580.0TransmembraneHelical
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139154_174325.0580.0TransmembraneHelical
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139191_211325.0580.0TransmembraneHelical
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139221_241325.0580.0TransmembraneHelical
TgeneSLC15A5chr19:16495939chr12:16392801ENST0000034494139304_324325.0580.0TransmembraneHelical
TgeneSLC15A5chr19:16495939chr12:16392801ENST000003449413977_97325.0580.0TransmembraneHelical


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Fusion Gene Sequence for EPS15L1-SLC15A5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000455140_ENST00000344941_TCGA-23-1023_EPS15L1_chr19_16495939_-_SLC15A5_chr12_16392801_length(transcript)=4262nt_BP=2314nt
AGTGCGCACGCGTGGCTGCAGCCCCGCCCCCGTTCCCCCGGCGCTCGGAGCCCGAGTCCGCGGGAAGATGGCGGCGCCGCTCATCCCCCT
CTCCCAGCAGATTCCCACTGGAAATTCGTTGTATGAATCTTATTACAAGCAGGTCGATCCGGCATACACAGGGAGGGTGGGGGCGAGTGA
AGCTGCGCTTTTTCTAAAGAAGTCTGGCCTCTCGGACATTATCCTTGGGAAGATATGGGACTTGGCCGATCCAGAAGGTAAAGGGTTCTT
GGACAAACAGGGTTTCTATGTTGCACTGAGACTGGTGGCCTGTGCACAGAGTGGCCATGAAGTTACCTTGAGCAATCTGAATTTGAGCAT
GCCACCGCCTAAATTTCACGACACCAGCAGCCCTCTGATGGTCACACCGCCCTCTGCAGAGGCCCACTGGGCTGTGAGGGTGGAAGAAAA
GGCCAAATTTGATGGGATTTTTGAAAGCCTCTTGCCCATCAATGGTTTGCTCTCTGGAGACAAAGTCAAGCCAGTCCTCATGAACTCAAA
GCTGCCTCTTGATGTCCTGGGCAGGGTCTGGGACCTCAGTGACATTGACAAGGATGGGCACTTGGATCGAGATGAGTTCGCTGTGGCCAT
GCACTTGGTGTACCGAGCCCTGGAGAAGGAGCCCGTGCCCTCCGCCCTGCCCCCGTCCCTCATCCCACCCTCCAAGAGAAAGAAGACTGT
GTTCCCTGGCGCCGTCCCCGTCCTGCCTGCCAGCCCCCCACCAAAAGACAGCCTCCGCTCCACGCCGTCCCACGGCAGCGTCAGCAGCCT
CAACAGCACAGGGAGCCTGTCCCCCAAGCACAGCCTCAAGCAAACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCG
ATTTGATGAGATATTCCTGAAGACCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCT
CACCCAGAACCTTCTAGCACACATATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTA
TTTCATTCAGCAGAAGGTCAGTAAAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGG
CCCGGACAGTTCAGGCTCTCTCGGCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAG
AGAGAAATATTCACTGGAACAAGACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCT
AGACCGGGAAACAAGCAGTTTGCAGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAA
GCTCCGAGACATGCTGAGCGACGTCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGA
ATCTGACTTAAAGTCCCAGGAAGACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAG
CATTCAGGCTGGGCGAGTCCAGCTGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTC
CCAGCTGCATGAAAGCCGCCAGGAGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGA
CCTGGCCAACCTGAGCGAAGGCGTCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGATGATCCTTTCAAAAATAAAGCCTTGTTATT
TAGCAACAACACGCAAGAGTTGCATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCCTTCAA
AGGCGACCCGTTCCAGAATGACCCCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGTGACCC
ATTCCGTGGCTCTGCCACTGACGACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCTTCCTT
ACCTTCGAAGCTCGACCCCTTTGAATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACCTTAGA
TCCCTTCGGAAGTGGGTCCTTCAATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGATTCCTTCAGGATATTATCTGCAAAC
TATGAATTCCAACCTGAATTTGGATGGATTTCTTCTGCCGATTGCAGTAATGAATGCCATCAGCAGCCTACCATTACTAATTCTGGCTCC
TTTTCTGGAGTATTTCAGCACCTGCCTGTTTCCCTCTAAGAGAGTTGGATCATTTCTGTCAACATGCATCATTGCTGGAAATCTTTTTGC
TGCATTGTCTGTGATGATAGCTGGCTTCTTTGAAATACACCGAAAACATTTCCCTGCAGTGGAGCAGCCCCTTTCAGGAAAAGTTCTCAC
TGTTTCCTCCATGCCCTGTTTCTACCTGATTCTTCAGTATGTTTTACTTGGAGTGGCGGAAACACTGGTAAACCCAGCCCTCTCTGTAAT
ATCATACAGATTTGTTCCAAGCAATGTCAGAGGAACCTCCATGAATTTTCTGACACTGTTCAATGGATTTGGCTGTTTCACAGGGGCACT
GCTGGTGAAGTTGGTATATCTCATCTCAGATGGCAATTGGTTTCCAAACACATTAAACAAAGGCAATTTAGAAAGCTTCTTCTTCTTCCT
GGCATCATTAACATTGTTGAACGTCCTGGGATTCTGCAGTGTTTCACAAAGATATTGTAATCTAAATCATTTTAATGCCCAGAACATCCG
TGGAAGTAATCTTGAAGAAACACTTCTCCTCCACGAAAAATCTCTGAAATTTTATGGCAGTATACAGGAATTTTCTTCAAGTATTGATCT
TTGGGAGACAGCCCTATGAAACTGTGTTTGAGTCTACCTGTCTTATGAGAACAGTATTCATTGTTTTCTTCTTCAGTTGAGCATTTTATG
TGTTTTAGTGTAAAAGCCAATATATACAGAGGTGATTTTACAAATATCATCTGTATACTTTATTTACAAAGACTAATTATGAATTTTCTA
GTAAACTGTCATGCTTTTGCATTAACATGTTATAGCATTAGAATTAATAAAATAATTTCAAAGTCTCAGTGATTACTCTATGACAAAAAA
AATGACAGTTTTCTATACACCAATAATACCTTACAGCTTTCTACAATGGTTCAGCCATTGAAAGCGTATGACCTTTTTTTTGGAGTTTTA
ATGAGTCATTAGAAGCAAAATGACAGTATTTTAATATACTCTCTTTCAATACACTTAGTGATCCCTTATTACACGTGACCTTATTACATT
GTGACCATATACTGTATATAACTGAGTAAATAATAAACATATACATGATTTTCTATATTTGCTGTTAATATTATGCTATCAAAATATGAC
TTCATTAAGGACATTTTCTCTGAATTTAAAAGCAGTATTACTAAAATAGATGTCCTTAACAAAGAGAATGTCCGCATACTAAAAAAGTTG
AAAAATAAATGTAAGTTATGGAATTATTGGAATTAAAAGAAAGAAGGAAATTAGGGAAGATAAAATGAGGGGGCTGAGAGGAGGGTAAGT
GACCAAACCAAATAGAGATGCTTAAAGGAATTATATGAATAACATCTTTCGGTCTCCACTGCCAATTCAGATGCATTCAGAAAATTATCT
TCTAAGAGTTTCTTCTTTCATAAGCAAAAATATGTGGAAACTCATTTTTTAAAAAATCAAATAAAATTAAAGTCTGTTTCTCAGTAGCAG
TATTTGTCAACATTTGGTTGAGGACAACTTGCTACAGGTGAATCTTTCTGGCCCCTATACAGACTGCCTTAACTCAAATCTTTTTTTGAG
ATTGGGGTCCAGCAATTGGTGGTTTTAATAAGCACACCCAAATCATTCTCATGTTCCCTAAGGTTTAAAAGCCATTGCTTTCCAGGACAA
TTCATGTTGGATAGGACAGGTGAGTTTATCAGCTGACTGCAAATTATTCTGCAATTATGCACCTCCCTTGTGTATACATAAAATATTTTA

>In-frame_ENST00000455140_ENST00000344941_TCGA-23-1023_EPS15L1_chr19_16495939_-_SLC15A5_chr12_16392801_length(amino acids)=1003AA_start in transcript=67_stop in transcript=3078
MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVT
LSNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD
RDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWV
VPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVP
PSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD
EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEI
NQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDP
FKGADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKG
SDPFGTLDPFGSGSFNSAEGFADFSQMSKIPSGYYLQTMNSNLNLDGFLLPIAVMNAISSLPLLILAPFLEYFSTCLFPSKRVGSFLSTC
IIAGNLFAALSVMIAGFFEIHRKHFPAVEQPLSGKVLTVSSMPCFYLILQYVLLGVAETLVNPALSVISYRFVPSNVRGTSMNFLTLFNG
FGCFTGALLVKLVYLISDGNWFPNTLNKGNLESFFFFLASLTLLNVLGFCSVSQRYCNLNHFNAQNIRGSNLEETLLLHEKSLKFYGSIQ

--------------------------------------------------------------
>In-frame_ENST00000248070_ENST00000344941_TCGA-23-1023_EPS15L1_chr19_16495939_-_SLC15A5_chr12_16392801_length(transcript)=4335nt_BP=2387nt
ACATGCGTGGCCCTGTCTACGGCCCCGCCCTCTCCCGGGACAGGCGGCCTGCGCACCGCCCTCCCGTCGTCCCAGTGCGCACGCGTGGCT
GCAGCCCCGCCCCCGTTCCCCCGGCGCTCGGAGCCCGAGTCCGCGGGAAGATGGCGGCGCCGCTCATCCCCCTCTCCCAGCAGATTCCCA
CTGGAAATTCGTTGTATGAATCTTATTACAAGCAGGTCGATCCGGCATACACAGGGAGGGTGGGGGCGAGTGAAGCTGCGCTTTTTCTAA
AGAAGTCTGGCCTCTCGGACATTATCCTTGGGAAGATATGGGACTTGGCCGATCCAGAAGGTAAAGGGTTCTTGGACAAACAGGGTTTCT
ATGTTGCACTGAGACTGGTGGCCTGTGCACAGAGTGGCCATGAAGTTACCTTGAGCAATCTGAATTTGAGCATGCCACCGCCTAAATTTC
ACGACACCAGCAGCCCTCTGATGGTCACACCGCCCTCTGCAGAGGCCCACTGGGCTGTGAGGGTGGAAGAAAAGGCCAAATTTGATGGGA
TTTTTGAAAGCCTCTTGCCCATCAATGGTTTGCTCTCTGGAGACAAAGTCAAGCCAGTCCTCATGAACTCAAAGCTGCCTCTTGATGTCC
TGGGCAGGGTCTGGGACCTCAGTGACATTGACAAGGATGGGCACTTGGATCGAGATGAGTTCGCTGTGGCCATGCACTTGGTGTACCGAG
CCCTGGAGAAGGAGCCCGTGCCCTCCGCCCTGCCCCCGTCCCTCATCCCACCCTCCAAGAGAAAGAAGACTGTGTTCCCTGGCGCCGTCC
CCGTCCTGCCTGCCAGCCCCCCACCAAAAGACAGCCTCCGCTCCACGCCGTCCCACGGCAGCGTCAGCAGCCTCAACAGCACAGGGAGCC
TGTCCCCCAAGCACAGCCTCAAGCAAACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCGATTTGATGAGATATTCC
TGAAGACCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCTCACCCAGAACCTTCTAG
CACACATATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTATTTCATTCAGCAGAAGG
TCAGTAAAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGGCCCGGACAGTTCAGGCT
CTCTCGGCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAGAGAGAAATATTCACTGG
AACAAGACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCTAGACCGGGAAACAAGCA
GTTTGCAGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAAGCTCCGAGACATGCTGA
GCGACGTCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGAATCTGACTTAAAGTCCC
AGGAAGACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAGCATTCAGGCTGGGCGAG
TCCAGCTGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTCCCAGCTGCATGAAAGCC
GCCAGGAGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGACCTGGCCAACCTGAGCG
AAGGCGTCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGATGATCCTTTCAAAAATAAAGCCTTGTTATTTAGCAACAACACGCAAG
AGTTGCATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCCTTCAAAGGCGACCCGTTCCAGA
ATGACCCCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGTGACCCATTCCGTGGCTCTGCCA
CTGACGACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCTTCCTTACCTTCGAAGCTCGACC
CCTTTGAATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACCTTAGATCCCTTCGGAAGTGGGT
CCTTCAATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGATTCCTTCAGGATATTATCTGCAAACTATGAATTCCAACCTGA
ATTTGGATGGATTTCTTCTGCCGATTGCAGTAATGAATGCCATCAGCAGCCTACCATTACTAATTCTGGCTCCTTTTCTGGAGTATTTCA
GCACCTGCCTGTTTCCCTCTAAGAGAGTTGGATCATTTCTGTCAACATGCATCATTGCTGGAAATCTTTTTGCTGCATTGTCTGTGATGA
TAGCTGGCTTCTTTGAAATACACCGAAAACATTTCCCTGCAGTGGAGCAGCCCCTTTCAGGAAAAGTTCTCACTGTTTCCTCCATGCCCT
GTTTCTACCTGATTCTTCAGTATGTTTTACTTGGAGTGGCGGAAACACTGGTAAACCCAGCCCTCTCTGTAATATCATACAGATTTGTTC
CAAGCAATGTCAGAGGAACCTCCATGAATTTTCTGACACTGTTCAATGGATTTGGCTGTTTCACAGGGGCACTGCTGGTGAAGTTGGTAT
ATCTCATCTCAGATGGCAATTGGTTTCCAAACACATTAAACAAAGGCAATTTAGAAAGCTTCTTCTTCTTCCTGGCATCATTAACATTGT
TGAACGTCCTGGGATTCTGCAGTGTTTCACAAAGATATTGTAATCTAAATCATTTTAATGCCCAGAACATCCGTGGAAGTAATCTTGAAG
AAACACTTCTCCTCCACGAAAAATCTCTGAAATTTTATGGCAGTATACAGGAATTTTCTTCAAGTATTGATCTTTGGGAGACAGCCCTAT
GAAACTGTGTTTGAGTCTACCTGTCTTATGAGAACAGTATTCATTGTTTTCTTCTTCAGTTGAGCATTTTATGTGTTTTAGTGTAAAAGC
CAATATATACAGAGGTGATTTTACAAATATCATCTGTATACTTTATTTACAAAGACTAATTATGAATTTTCTAGTAAACTGTCATGCTTT
TGCATTAACATGTTATAGCATTAGAATTAATAAAATAATTTCAAAGTCTCAGTGATTACTCTATGACAAAAAAAATGACAGTTTTCTATA
CACCAATAATACCTTACAGCTTTCTACAATGGTTCAGCCATTGAAAGCGTATGACCTTTTTTTTGGAGTTTTAATGAGTCATTAGAAGCA
AAATGACAGTATTTTAATATACTCTCTTTCAATACACTTAGTGATCCCTTATTACACGTGACCTTATTACATTGTGACCATATACTGTAT
ATAACTGAGTAAATAATAAACATATACATGATTTTCTATATTTGCTGTTAATATTATGCTATCAAAATATGACTTCATTAAGGACATTTT
CTCTGAATTTAAAAGCAGTATTACTAAAATAGATGTCCTTAACAAAGAGAATGTCCGCATACTAAAAAAGTTGAAAAATAAATGTAAGTT
ATGGAATTATTGGAATTAAAAGAAAGAAGGAAATTAGGGAAGATAAAATGAGGGGGCTGAGAGGAGGGTAAGTGACCAAACCAAATAGAG
ATGCTTAAAGGAATTATATGAATAACATCTTTCGGTCTCCACTGCCAATTCAGATGCATTCAGAAAATTATCTTCTAAGAGTTTCTTCTT
TCATAAGCAAAAATATGTGGAAACTCATTTTTTAAAAAATCAAATAAAATTAAAGTCTGTTTCTCAGTAGCAGTATTTGTCAACATTTGG
TTGAGGACAACTTGCTACAGGTGAATCTTTCTGGCCCCTATACAGACTGCCTTAACTCAAATCTTTTTTTGAGATTGGGGTCCAGCAATT
GGTGGTTTTAATAAGCACACCCAAATCATTCTCATGTTCCCTAAGGTTTAAAAGCCATTGCTTTCCAGGACAATTCATGTTGGATAGGAC
AGGTGAGTTTATCAGCTGACTGCAAATTATTCTGCAATTATGCACCTCCCTTGTGTATACATAAAATATTTTAGGTCTGTAGAATAAAAG

>In-frame_ENST00000248070_ENST00000344941_TCGA-23-1023_EPS15L1_chr19_16495939_-_SLC15A5_chr12_16392801_length(amino acids)=1049AA_start in transcript=2_stop in transcript=3151
MRGPVYGPALSRDRRPAHRPPVVPVRTRGCSPAPVPPALGARVRGKMAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLK
KSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGI
FESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVP
VLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLA
HIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLE
QDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQ
EDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSE
GVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSAT
DDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGTLDPFGSGSFNSAEGFADFSQMSKIPSGYYLQTMNSNLN
LDGFLLPIAVMNAISSLPLLILAPFLEYFSTCLFPSKRVGSFLSTCIIAGNLFAALSVMIAGFFEIHRKHFPAVEQPLSGKVLTVSSMPC
FYLILQYVLLGVAETLVNPALSVISYRFVPSNVRGTSMNFLTLFNGFGCFTGALLVKLVYLISDGNWFPNTLNKGNLESFFFFLASLTLL

--------------------------------------------------------------
>In-frame_ENST00000535753_ENST00000344941_TCGA-23-1023_EPS15L1_chr19_16495939_-_SLC15A5_chr12_16392801_length(transcript)=4226nt_BP=2278nt
CCCGGCGCTCGGAGCCCGAGTCCGCGGGAAGATGGCGGCGCCGCTCATCCCCCTCTCCCAGCAGATTCCCACTGGAAATTCGTTGTATGA
ATCTTATTACAAGCAGGTCGATCCGGCATACACAGGGAGGGTGGGGGCGAGTGAAGCTGCGCTTTTTCTAAAGAAGTCTGGCCTCTCGGA
CATTATCCTTGGGAAGATATGGGACTTGGCCGATCCAGAAGGTAAAGGGTTCTTGGACAAACAGGGTTTCTATGTTGCACTGAGACTGGT
GGCCTGTGCACAGAGTGGCCATGAAGTTACCTTGAGCAATCTGAATTTGAGCATGCCACCGCCTAAATTTCACGACACCAGCAGCCCTCT
GATGGTCACACCGCCCTCTGCAGAGGCCCACTGGGCTGTGAGGGTGGAAGAAAAGGCCAAATTTGATGGGATTTTTGAAAGCCTCTTGCC
CATCAATGGTTTGCTCTCTGGAGACAAAGTCAAGCCAGTCCTCATGAACTCAAAGCTGCCTCTTGATGTCCTGGGCAGGGTCTGGGACCT
CAGTGACATTGACAAGGATGGGCACTTGGATCGAGATGAGTTCGCTGTGGCCATGCACTTGGTGTACCGAGCCCTGGAGAAGGAGCCCGT
GCCCTCCGCCCTGCCCCCGTCCCTCATCCCACCCTCCAAGAGAAAGAAGACTGTGTTCCCTGGCGCCGTCCCCGTCCTGCCTGCCAGCCC
CCCACCAAAAGACAGCCTCCGCTCCACGCCGTCCCACGGCAGCGTCAGCAGCCTCAACAGCACAGGGAGCCTGTCCCCCAAGCACAGCCT
CAAGCAAACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCGATTTGATGAGATATTCCTGAAGACCGACCTGGACCT
GGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCTCACCCAGAACCTTCTAGCACACATATGGGCCCTGGC
CGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTATTTCATTCAGCAGAAGGTCAGTAAAGGCATCGACCC
TCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGGCCCGGACAGTTCAGGCTCTCTCGGCTCCGGGGAGTT
TACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAGAGAGAAATATTCACTGGAACAAGACATTCGAGAAAA
GGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCTAGACCGGGAAACAAGCAGTTTGCAGGAGCTCGAGGC
TCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAAGCTCCGAGACATGCTGAGCGACGTCCGGCAGAAGTG
CCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGAATCTGACTTAAAGTCCCAGGAAGACGATCTGAACCG
AGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAGCATTCAGGCTGGGCGAGTCCAGCTGGAAACCATCAT
CAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTCCCAGCTGCATGAAAGCCGCCAGGAGGCCCACAGGAG
CCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGACCTGGCCAACCTGAGCGAAGGCGTCTCCCTGGCAGA
GAGGGGCAGTTTTGGAGCCATGGATGATCCTTTCAAAAATAAAGCCTTGTTATTTAGCAACAACACGCAAGAGTTGCATCCGGATCCTTT
CCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCCTTCAAAGGCGACCCGTTCCAGAATGACCCCTTTGCAGAACA
GCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGTGACCCATTCCGTGGCTCTGCCACTGACGACTTCTTCAAGAA
ACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCTTCCTTACCTTCGAAGCTCGACCCCTTTGAATCCAGTGATCC
CTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACCTTAGATCCCTTCGGAAGTGGGTCCTTCAATAGTGCTGAAGG
CTTTGCCGACTTCAGCCAGATGTCCAAGATTCCTTCAGGATATTATCTGCAAACTATGAATTCCAACCTGAATTTGGATGGATTTCTTCT
GCCGATTGCAGTAATGAATGCCATCAGCAGCCTACCATTACTAATTCTGGCTCCTTTTCTGGAGTATTTCAGCACCTGCCTGTTTCCCTC
TAAGAGAGTTGGATCATTTCTGTCAACATGCATCATTGCTGGAAATCTTTTTGCTGCATTGTCTGTGATGATAGCTGGCTTCTTTGAAAT
ACACCGAAAACATTTCCCTGCAGTGGAGCAGCCCCTTTCAGGAAAAGTTCTCACTGTTTCCTCCATGCCCTGTTTCTACCTGATTCTTCA
GTATGTTTTACTTGGAGTGGCGGAAACACTGGTAAACCCAGCCCTCTCTGTAATATCATACAGATTTGTTCCAAGCAATGTCAGAGGAAC
CTCCATGAATTTTCTGACACTGTTCAATGGATTTGGCTGTTTCACAGGGGCACTGCTGGTGAAGTTGGTATATCTCATCTCAGATGGCAA
TTGGTTTCCAAACACATTAAACAAAGGCAATTTAGAAAGCTTCTTCTTCTTCCTGGCATCATTAACATTGTTGAACGTCCTGGGATTCTG
CAGTGTTTCACAAAGATATTGTAATCTAAATCATTTTAATGCCCAGAACATCCGTGGAAGTAATCTTGAAGAAACACTTCTCCTCCACGA
AAAATCTCTGAAATTTTATGGCAGTATACAGGAATTTTCTTCAAGTATTGATCTTTGGGAGACAGCCCTATGAAACTGTGTTTGAGTCTA
CCTGTCTTATGAGAACAGTATTCATTGTTTTCTTCTTCAGTTGAGCATTTTATGTGTTTTAGTGTAAAAGCCAATATATACAGAGGTGAT
TTTACAAATATCATCTGTATACTTTATTTACAAAGACTAATTATGAATTTTCTAGTAAACTGTCATGCTTTTGCATTAACATGTTATAGC
ATTAGAATTAATAAAATAATTTCAAAGTCTCAGTGATTACTCTATGACAAAAAAAATGACAGTTTTCTATACACCAATAATACCTTACAG
CTTTCTACAATGGTTCAGCCATTGAAAGCGTATGACCTTTTTTTTGGAGTTTTAATGAGTCATTAGAAGCAAAATGACAGTATTTTAATA
TACTCTCTTTCAATACACTTAGTGATCCCTTATTACACGTGACCTTATTACATTGTGACCATATACTGTATATAACTGAGTAAATAATAA
ACATATACATGATTTTCTATATTTGCTGTTAATATTATGCTATCAAAATATGACTTCATTAAGGACATTTTCTCTGAATTTAAAAGCAGT
ATTACTAAAATAGATGTCCTTAACAAAGAGAATGTCCGCATACTAAAAAAGTTGAAAAATAAATGTAAGTTATGGAATTATTGGAATTAA
AAGAAAGAAGGAAATTAGGGAAGATAAAATGAGGGGGCTGAGAGGAGGGTAAGTGACCAAACCAAATAGAGATGCTTAAAGGAATTATAT
GAATAACATCTTTCGGTCTCCACTGCCAATTCAGATGCATTCAGAAAATTATCTTCTAAGAGTTTCTTCTTTCATAAGCAAAAATATGTG
GAAACTCATTTTTTAAAAAATCAAATAAAATTAAAGTCTGTTTCTCAGTAGCAGTATTTGTCAACATTTGGTTGAGGACAACTTGCTACA
GGTGAATCTTTCTGGCCCCTATACAGACTGCCTTAACTCAAATCTTTTTTTGAGATTGGGGTCCAGCAATTGGTGGTTTTAATAAGCACA
CCCAAATCATTCTCATGTTCCCTAAGGTTTAAAAGCCATTGCTTTCCAGGACAATTCATGTTGGATAGGACAGGTGAGTTTATCAGCTGA

>In-frame_ENST00000535753_ENST00000344941_TCGA-23-1023_EPS15L1_chr19_16495939_-_SLC15A5_chr12_16392801_length(amino acids)=1003AA_start in transcript=31_stop in transcript=3042
MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVT
LSNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD
RDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWV
VPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVP
PSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD
EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEI
NQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDP
FKGADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKG
SDPFGTLDPFGSGSFNSAEGFADFSQMSKIPSGYYLQTMNSNLNLDGFLLPIAVMNAISSLPLLILAPFLEYFSTCLFPSKRVGSFLSTC
IIAGNLFAALSVMIAGFFEIHRKHFPAVEQPLSGKVLTVSSMPCFYLILQYVLLGVAETLVNPALSVISYRFVPSNVRGTSMNFLTLFNG
FGCFTGALLVKLVYLISDGNWFPNTLNKGNLESFFFFLASLTLLNVLGFCSVSQRYCNLNHFNAQNIRGSNLEETLLLHEKSLKFYGSIQ

--------------------------------------------------------------
>In-frame_ENST00000594975_ENST00000344941_TCGA-23-1023_EPS15L1_chr19_16495939_-_SLC15A5_chr12_16392801_length(transcript)=4341nt_BP=2393nt
ACATGCGTGGCCCTGTCTACGGCCCCGCCCTCTCCCGGGACAGGCGGCCTGCGCACCGCCCTCCCGTCGTCCCAGTGCGCACGCGTGGCT
GCAGCCCCGCCCCCGTTCCCCCGGCGCTCGGAGCCCGAGTCCGCGGGAAGATGGCGGCGCCGCTCATCCCCCTCTCCCAGCAGATTCCCA
CTGGAAATTCGTTGTATGAATCTTATTACAAGCAGGTCGATCCGGCATACACAGGGAGGGTGGGGGCGAGTGAAGCTGCGCTTTTTCTAA
AGAAGTCTGGCCTCTCGGACATTATCCTTGGGAAGATATGGGACTTGGCCGATCCAGAAGGTAAAGGGTTCTTGGACAAACAGGGTTTCT
ATGTTGCACTGAGACTGGTGGCCTGTGCACAGAGTGGCCATGAAGTTACCTTGAGCAATCTGAATTTGAGCATGCCACCGCCTAAATTTC
ACGACACCAGCAGCCCTCTGATGGTCACACCGCCCTCTGCAGAGGCCCACTGGGCTGTGAGGGTGGAAGAAAAGGCCAAATTTGATGGGA
TTTTTGAAAGCCTCTTGCCCATCAATGGTTTGCTCTCTGGAGACAAAGTCAAGCCAGTCCTCATGAACTCAAAGCTGCCTCTTGATGTCC
TGGGCAGGGTCTGGGACCTCAGTGACATTGACAAGGATGGGCACTTGGATCGAGATGAGTTCGCTGTGGCCATGCACTTGGTGTACCGAG
CCCTGGAGAAGGAGCCCGTGCCCTCCGCCCTGCCCCCGTCCCTCATCCCACCCTCCAAGAGAAAGAAGACTGTGTTCCCTGGCGCCGTCC
CCGTCCTGCCTGCCAGCCCCCCACCAAAAGACAGCCTCCGCTCCACGCCGTCCCACGGCAGCGTCAGCAGCCTCAACAGCACAGGGAGCC
TGTCCCCCAAGCACAGCCTCAAGCAAACACAGCCAACAGTGAACTGGGTGGTGCCCGTGGCAGACAAGATGCGATTTGATGAGATATTCC
TGAAGACCGACCTGGACCTGGATGGCTACGTGAGTGGCCAGGAGGTGAAGGAGATCTTCATGCACTCGGGCCTCACCCAGAACCTTCTAG
CACACATATGGGCCCTGGCCGATACGAGGCAAACGGGGAAGTTAAGCAAAGACCAATTCGCGTTAGCTATGTATTTCATTCAGCAGAAGG
TCAGTAAAGGCATCGACCCTCCTCAAGTCCTCTCGCCGGACATGGTCCCGCCTTCGGAGAGAGGCACGCCCGGCCCGGACAGTTCAGGCT
CTCTCGGCTCCGGGGAGTTTACTGGCGTGAAGGAGCTTGATGACATCAGTCAAGAGATTGCCCAGTTACAAAGAGAGAAATATTCACTGG
AACAAGACATTCGAGAAAAGGAAGAGGCAATCAGACAGAAAACCAGCGAGGTGCAGGAATTACAAAATGACCTAGACCGGGAAACAAGCA
GTTTGCAGGAGCTCGAGGCTCAGAAACAGGATGCTCAAGACCGCCTGGACGAGATGGACCAGCAGAAGGCCAAGCTCCGAGACATGCTGA
GCGACGTCCGGCAGAAGTGCCAGGATGAGACTCAGATGATCTCATCACTGAAAACGCAAATCCAATCTCAGGAATCTGACTTAAAGTCCC
AGGAAGACGATCTGAACCGAGCCAAGTCGGAGCTGAACCGATTGCAGCAGGAGGAAACCCAGCTGGAGCAGAGCATTCAGGCTGGGCGAG
TCCAGCTGGAAACCATCATCAAGTCCCTGAAGTCAACGCAAGACGAAATCAACCAGGCAAGGAGCAAACTTTCCCAGCTGCATGAAAGCC
GCCAGGAGGCCCACAGGAGCCTGGAGCAGTATGACCAGGTGCTCGATGGAGCCCATGGTGCCAGCCTGACCGACCTGGCCAACCTGAGCG
AAGGCGTCTCCCTGGCAGAGAGGGGCAGTTTTGGAGCCATGGTAAAGGATGATCCTTTCAAAAATAAAGCCTTGTTATTTAGCAACAACA
CGCAAGAGTTGCATCCGGATCCTTTCCAGACAGAAGACCCCTTCAAATCTGACCCATTTAAAGGAGCTGACCCCTTCAAAGGCGACCCGT
TCCAGAATGACCCCTTTGCAGAACAGCAGACAACTTCAACAGATCCATTTGGAGGGGACCCTTTCAAAGAAAGTGACCCATTCCGTGGCT
CTGCCACTGACGACTTCTTCAAGAAACAGACAAAGAATGACCCATTTACCTCGGATCCATTCACGAAAAACCCTTCCTTACCTTCGAAGC
TCGACCCCTTTGAATCCAGTGATCCCTTTTCATCCTCCAGTGTCTCCTCAAAAGGATCAGATCCCTTTGGAACCTTAGATCCCTTCGGAA
GTGGGTCCTTCAATAGTGCTGAAGGCTTTGCCGACTTCAGCCAGATGTCCAAGATTCCTTCAGGATATTATCTGCAAACTATGAATTCCA
ACCTGAATTTGGATGGATTTCTTCTGCCGATTGCAGTAATGAATGCCATCAGCAGCCTACCATTACTAATTCTGGCTCCTTTTCTGGAGT
ATTTCAGCACCTGCCTGTTTCCCTCTAAGAGAGTTGGATCATTTCTGTCAACATGCATCATTGCTGGAAATCTTTTTGCTGCATTGTCTG
TGATGATAGCTGGCTTCTTTGAAATACACCGAAAACATTTCCCTGCAGTGGAGCAGCCCCTTTCAGGAAAAGTTCTCACTGTTTCCTCCA
TGCCCTGTTTCTACCTGATTCTTCAGTATGTTTTACTTGGAGTGGCGGAAACACTGGTAAACCCAGCCCTCTCTGTAATATCATACAGAT
TTGTTCCAAGCAATGTCAGAGGAACCTCCATGAATTTTCTGACACTGTTCAATGGATTTGGCTGTTTCACAGGGGCACTGCTGGTGAAGT
TGGTATATCTCATCTCAGATGGCAATTGGTTTCCAAACACATTAAACAAAGGCAATTTAGAAAGCTTCTTCTTCTTCCTGGCATCATTAA
CATTGTTGAACGTCCTGGGATTCTGCAGTGTTTCACAAAGATATTGTAATCTAAATCATTTTAATGCCCAGAACATCCGTGGAAGTAATC
TTGAAGAAACACTTCTCCTCCACGAAAAATCTCTGAAATTTTATGGCAGTATACAGGAATTTTCTTCAAGTATTGATCTTTGGGAGACAG
CCCTATGAAACTGTGTTTGAGTCTACCTGTCTTATGAGAACAGTATTCATTGTTTTCTTCTTCAGTTGAGCATTTTATGTGTTTTAGTGT
AAAAGCCAATATATACAGAGGTGATTTTACAAATATCATCTGTATACTTTATTTACAAAGACTAATTATGAATTTTCTAGTAAACTGTCA
TGCTTTTGCATTAACATGTTATAGCATTAGAATTAATAAAATAATTTCAAAGTCTCAGTGATTACTCTATGACAAAAAAAATGACAGTTT
TCTATACACCAATAATACCTTACAGCTTTCTACAATGGTTCAGCCATTGAAAGCGTATGACCTTTTTTTTGGAGTTTTAATGAGTCATTA
GAAGCAAAATGACAGTATTTTAATATACTCTCTTTCAATACACTTAGTGATCCCTTATTACACGTGACCTTATTACATTGTGACCATATA
CTGTATATAACTGAGTAAATAATAAACATATACATGATTTTCTATATTTGCTGTTAATATTATGCTATCAAAATATGACTTCATTAAGGA
CATTTTCTCTGAATTTAAAAGCAGTATTACTAAAATAGATGTCCTTAACAAAGAGAATGTCCGCATACTAAAAAAGTTGAAAAATAAATG
TAAGTTATGGAATTATTGGAATTAAAAGAAAGAAGGAAATTAGGGAAGATAAAATGAGGGGGCTGAGAGGAGGGTAAGTGACCAAACCAA
ATAGAGATGCTTAAAGGAATTATATGAATAACATCTTTCGGTCTCCACTGCCAATTCAGATGCATTCAGAAAATTATCTTCTAAGAGTTT
CTTCTTTCATAAGCAAAAATATGTGGAAACTCATTTTTTAAAAAATCAAATAAAATTAAAGTCTGTTTCTCAGTAGCAGTATTTGTCAAC
ATTTGGTTGAGGACAACTTGCTACAGGTGAATCTTTCTGGCCCCTATACAGACTGCCTTAACTCAAATCTTTTTTTGAGATTGGGGTCCA
GCAATTGGTGGTTTTAATAAGCACACCCAAATCATTCTCATGTTCCCTAAGGTTTAAAAGCCATTGCTTTCCAGGACAATTCATGTTGGA
TAGGACAGGTGAGTTTATCAGCTGACTGCAAATTATTCTGCAATTATGCACCTCCCTTGTGTATACATAAAATATTTTAGGTCTGTAGAA

>In-frame_ENST00000594975_ENST00000344941_TCGA-23-1023_EPS15L1_chr19_16495939_-_SLC15A5_chr12_16392801_length(amino acids)=1051AA_start in transcript=2_stop in transcript=3157
MRGPVYGPALSRDRRPAHRPPVVPVRTRGCSPAPVPPALGARVRGKMAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLK
KSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGI
FESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVP
VLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLA
HIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLE
QDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQ
EDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSE
GVSLAERGSFGAMVKDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGS
ATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGTLDPFGSGSFNSAEGFADFSQMSKIPSGYYLQTMNSN
LNLDGFLLPIAVMNAISSLPLLILAPFLEYFSTCLFPSKRVGSFLSTCIIAGNLFAALSVMIAGFFEIHRKHFPAVEQPLSGKVLTVSSM
PCFYLILQYVLLGVAETLVNPALSVISYRFVPSNVRGTSMNFLTLFNGFGCFTGALLVKLVYLISDGNWFPNTLNKGNLESFFFFLASLT

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Fusion Gene PPI Analysis for EPS15L1-SLC15A5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000248070-212315_368749.0865.0DAB2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000455140-212415_368749.0911.0DAB2
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000535753-212215_368749.0755.0DAB2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEPS15L1chr19:16495939chr12:16392801ENST00000597937-11615_3680602.0DAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EPS15L1-SLC15A5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EPS15L1-SLC15A5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEPS15L1C0265554Ectrodactyly1ORPHANET