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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EPT1-CHST8 (FusionGDB2 ID:27087)

Fusion Gene Summary for EPT1-CHST8

check button Fusion gene summary
Fusion gene informationFusion gene name: EPT1-CHST8
Fusion gene ID: 27087
HgeneTgene
Gene symbol

EPT1

CHST8

Gene ID

85465

64377

Gene nameselenoprotein Icarbohydrate sulfotransferase 8
SynonymsEPT1|SELI|SEPI|SPG81GALNAC4ST1|GalNAc4ST|PSS3
Cytomap

2p23.3

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionethanolaminephosphotransferase 1ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)hEPT1carbohydrate sulfotransferase 8GALNAC-4-ST1GalNAc-4-O-sulfotransferase 1N-acetylgalactosamine-4-O-sulfotransferase 1carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8galNAc4ST-1
Modification date2020031320200313
UniProtAcc.

Q9H2A9

Ensembl transtripts involved in fusion geneENST00000260585, ENST00000462301, 
ENST00000434302, ENST00000438847, 
ENST00000604556, ENST00000262622, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 4=64
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPT1 [Title/Abstract] AND CHST8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEPT1(26598016)-CHST8(34262317), # samples:1
EPT1(26596497)-CHST8(34262317), # samples:1
Anticipated loss of major functional domain due to fusion event.EPT1-CHST8 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EPT1-CHST8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEPT1

GO:0006646

phosphatidylethanolamine biosynthetic process

17132865

TgeneCHST8

GO:0006790

sulfur compound metabolic process

11445554

TgeneCHST8

GO:0030166

proteoglycan biosynthetic process

10988300


check buttonFusion gene breakpoints across EPT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CHST8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-20-1686EPT1chr2

26598016

+CHST8chr19

34262317

+
ChimerDB4OVTCGA-20-1686EPT1chr2

26596497

+CHST8chr19

34262317

+


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Fusion Gene ORF analysis for EPT1-CHST8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000260585ENST00000434302EPT1chr2

26598016

+CHST8chr19

34262317

+
In-frameENST00000260585ENST00000438847EPT1chr2

26598016

+CHST8chr19

34262317

+
5CDS-intronENST00000260585ENST00000604556EPT1chr2

26598016

+CHST8chr19

34262317

+
5CDS-intronENST00000260585ENST00000262622EPT1chr2

26598016

+CHST8chr19

34262317

+
intron-3CDSENST00000462301ENST00000434302EPT1chr2

26598016

+CHST8chr19

34262317

+
intron-3CDSENST00000462301ENST00000438847EPT1chr2

26598016

+CHST8chr19

34262317

+
intron-intronENST00000462301ENST00000604556EPT1chr2

26598016

+CHST8chr19

34262317

+
intron-intronENST00000462301ENST00000262622EPT1chr2

26598016

+CHST8chr19

34262317

+
Frame-shiftENST00000260585ENST00000434302EPT1chr2

26596497

+CHST8chr19

34262317

+
Frame-shiftENST00000260585ENST00000438847EPT1chr2

26596497

+CHST8chr19

34262317

+
5CDS-intronENST00000260585ENST00000604556EPT1chr2

26596497

+CHST8chr19

34262317

+
5CDS-intronENST00000260585ENST00000262622EPT1chr2

26596497

+CHST8chr19

34262317

+
intron-3CDSENST00000462301ENST00000434302EPT1chr2

26596497

+CHST8chr19

34262317

+
intron-3CDSENST00000462301ENST00000438847EPT1chr2

26596497

+CHST8chr19

34262317

+
intron-intronENST00000462301ENST00000604556EPT1chr2

26596497

+CHST8chr19

34262317

+
intron-intronENST00000462301ENST00000262622EPT1chr2

26596497

+CHST8chr19

34262317

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000260585EPT1chr226598016+ENST00000434302CHST8chr1934262317+23918011191945608
ENST00000260585EPT1chr226598016+ENST00000438847CHST8chr1934262317+23928011191945608

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260585ENST00000434302EPT1chr226598016+CHST8chr1934262317+0.0093280520.990672
ENST00000260585ENST00000438847EPT1chr226598016+CHST8chr1934262317+0.0094972830.9905027

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Fusion Genomic Features for EPT1-CHST8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EPT1chr226598016+CHST8chr1934262317+0.0242999070.9757001
EPT1chr226596497+CHST8chr1934262317+0.010376570.98962337
EPT1chr226598016+CHST8chr1934262317+0.0242999070.9757001
EPT1chr226596497+CHST8chr1934262317+0.010376570.98962337

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EPT1-CHST8


check button Go to

FGviewer for the breakpoints of chr2:26598016-chr19:34262317

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CHST8

Q9H2A9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. {ECO:0000269|PubMed:10988300, ECO:0000269|PubMed:11445554}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+610123_145227.33333333333334398.0TransmembraneHelical
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+610150_172227.33333333333334398.0TransmembraneHelical
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+610179_201227.33333333333334398.0TransmembraneHelical
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+61047_69227.33333333333334398.0TransmembraneHelical
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+61084_103227.33333333333334398.0TransmembraneHelical
TgeneCHST8chr2:26598016chr19:34262317ENST0000026262214198_20443.333333333333336425.0Nucleotide bindingPAPS
TgeneCHST8chr2:26598016chr19:34262317ENST0000026262214258_26643.333333333333336425.0Nucleotide bindingPAPS
TgeneCHST8chr2:26598016chr19:34262317ENST0000043430225198_20443.333333333333336425.0Nucleotide bindingPAPS
TgeneCHST8chr2:26598016chr19:34262317ENST0000043430225258_26643.333333333333336425.0Nucleotide bindingPAPS
TgeneCHST8chr2:26598016chr19:34262317ENST0000043884714198_20443.333333333333336425.0Nucleotide bindingPAPS
TgeneCHST8chr2:26598016chr19:34262317ENST0000043884714258_26643.333333333333336425.0Nucleotide bindingPAPS

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+610221_243227.33333333333334398.0TransmembraneHelical
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+610256_278227.33333333333334398.0TransmembraneHelical
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+610291_310227.33333333333334398.0TransmembraneHelical
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+610317_339227.33333333333334398.0TransmembraneHelical
HgeneEPT1chr2:26598016chr19:34262317ENST00000260585+610344_366227.33333333333334398.0TransmembraneHelical
TgeneCHST8chr2:26598016chr19:34262317ENST00000262622141_1043.333333333333336425.0Topological domainCytoplasmic
TgeneCHST8chr2:26598016chr19:34262317ENST000002626221432_42443.333333333333336425.0Topological domainLumenal
TgeneCHST8chr2:26598016chr19:34262317ENST00000434302251_1043.333333333333336425.0Topological domainCytoplasmic
TgeneCHST8chr2:26598016chr19:34262317ENST000004343022532_42443.333333333333336425.0Topological domainLumenal
TgeneCHST8chr2:26598016chr19:34262317ENST00000438847141_1043.333333333333336425.0Topological domainCytoplasmic
TgeneCHST8chr2:26598016chr19:34262317ENST000004388471432_42443.333333333333336425.0Topological domainLumenal
TgeneCHST8chr2:26598016chr19:34262317ENST000002626221411_3143.333333333333336425.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCHST8chr2:26598016chr19:34262317ENST000004343022511_3143.333333333333336425.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCHST8chr2:26598016chr19:34262317ENST000004388471411_3143.333333333333336425.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for EPT1-CHST8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000260585_ENST00000434302_TCGA-20-1686_EPT1_chr2_26598016_+_CHST8_chr19_34262317_length(transcript)=2391nt_BP=801nt
CTCCTACCTTCTCGGGCAGCCCAGTCTTTGCCATCCTTGCCCAGCCGGTGTGGTGCTTGTGTGTCACAGCCTTGTAGCCGGGAGTCGCTG
CCGAGTGGGCGCTCAGTTTTCGGGTCGTCATGGCTGGCTACGAATACGTGAGCCCGGAGCAGCTGGCTGGCTTTGATAAGTACAAGTACA
GTGCTGTGGATACCAATCCACTTTCTCTGTATGTCATGCATCCATTCTGGAACACTATAGTAAAGGTATTTCCTACTTGGCTGGCGCCCA
ATCTGATAACTTTTTCTGGCTTTCTGCTGGTCGTATTCAATTTTCTGCTAATGGCATACTTTGATCCTGACTTTTATGCCTCAGCACCAG
GTCACAAGCACGTGCCTGACTGGGTTTGGATTGTAGTGGGCATCCTCAACTTCGTAGCCTACACTCTAGATGGTGTGGACGGAAAGCAAG
CTCGCAGAACCAATTCTAGCACTCCCTTAGGGGAGCTTTTTGATCATGGCCTGGATAGTTGGTCATGTGTTTACTTTGTTGTGACTGTTT
ATTCCATCTTTGGAAGAGGATCAACTGGTGTCAGTGTTTTTGTTCTTTATCTCCTGCTATGGGTAGTTTTGTTTTCTTTCATCCTGTCCC
ACTGGGAAAAGTATAACACAGGGATTCTTTTCCTGCCATGGGGATATGACATTAGCCAGGTGACTATTTCTTTTGTCTACATAGTGACTG
CAGTTGTGGGAGTTGAGGCCTGGTATGAACCTTTCCTGTTTAATTTCTTATATAGAGACCTATTCACTGCAATGATTATTGGAATAAAGT
TCAACATCAGGCCAAGGCAGCCCCACCACGACCTCCCACCAGGCGGCTCCCAGGATGGTGACTTGAAGGAACCCACAGAGAGGGTCACTC
GGGACTTATCCAGTGGGGCCCCGAGGGGCCGCAACCTGCCAGCGCCTGACCAGCCTCAACCCCCGCTGCAGAGGGGAACCCGTCTGCGGC
TCCGCCAGCGCCGTCGCCGTCTGCTCATCAAGAAAATGCCAGCTGCGGCGACCATCCCGGCCAACAGCTCGGACGCGCCCTTCATCCGGC
CGGGACCCGGGACGCTGGATGGCCGCTGGGTCAGCCTGCACCGGAGCCAGCAGGAGCGCAAGCGGGTGATGCAGGAGGCCTGCGCCAAGT
ACCGGGCGAGCAGCAGCCGCCGGGCCGTCACGCCCCGCCACGTGTCCCGTATCTTCGTGGAGGACCGCCACCGCGTGCTCTACTGCGAGG
TGCCCAAGGCCGGCTGCTCCAATTGGAAGCGGGTGCTCATGGTGCTGGCCGGCCTGGCCTCGTCCACTGCCGACATCCAGCACAACACCG
TCCACTATGGCAGCGCTCTCAAGCGCCTGGACACCTTCGACCGCCAGGGTATCTTGCACCGTCTCAGCACCTACACCAAGATGCTCTTTG
TCCGCGAGCCCTTCGAGAGGCTGGTGTCCGCCTTCCGCGACAAGTTTGAGCACCCCAACAGCTACTATCACCCGGTCTTCGGCAAGGCCA
TCCTGGCCCGGTACCGCGCCAATGCCTCTCGGGAGGCCCTGCGGACCGGCTCTGGGGTGCGTTTTCCCGAGTTCGTCCAGTACCTGCTGG
ACGTGCACCGGCCCGTGGGGATGGACATTCACTGGGACCATGTCAGCCGGCTCTGCAGCCCCTGCCTCATCGACTACGATTTCGTAGGCA
AGTTCGAGAGCATGGAGGACGATGCCAACTTCTTCCTGAGCCTCATCCGCGCGCCGCGGAACCTGACCTTCCCCCGGTTCAAGGACCGGC
ACTCGCAGGAGGCGCGGACCACAGCGAGGATCGCCCACCAGTACTTCGCCCAACTCTCGGCCCTGCAAAGGCAGCGCACCTACGACTTCT
ACTACATGGATTACCTGATGTTCAACTATTCCAAGCCCTTTGCAGATCTGTACTGAGGGGCGCCGCAGCTGGCCGGGGCCGCCCTGCCCC
GGTCACTCACCTGTGCTCCCGGGCATCCTCCTGTCCCTGGCTCCTCATCCTGGGAGCAACAGGGCTCTGAGGACGTGAGGAGCCATCGCT
GTGGGAGGCAGCAGGCCCCGGGTGGGGGGCAGAGGCGCCCAGCCTTGGATGGGGACCCCAGCCCCTGGCCTGTACCTGTTTCCTCATTCC
TTGGCTGAGGGAGAGGCTGAGAACTGGGCAGACACCCCTGGAGCTCAGCCGACAGTTTTGATGAGCAGGGAAGTCTGAGGCCCAGAGGAC
GGGGGGCCCAGCGGTAAGGGATGTCCCGCACTCCCTTAGCCATTGCCTTGGACCAAACCACGTGGTTTGCAGCTTTTCTACGAGCCAGGG

>In-frame_ENST00000260585_ENST00000434302_TCGA-20-1686_EPT1_chr2_26598016_+_CHST8_chr19_34262317_length(amino acids)=608AA_start in transcript=119_stop in transcript=1945
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVW
IVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTGVSVFVLYLLLWVVLFSFILSHWEKYNTGIL
FLPWGYDISQVTISFVYIVTAVVGVEAWYEPFLFNFLYRDLFTAMIIGIKFNIRPRQPHHDLPPGGSQDGDLKEPTERVTRDLSSGAPRG
RNLPAPDQPQPPLQRGTRLRLRQRRRRLLIKKMPAAATIPANSSDAPFIRPGPGTLDGRWVSLHRSQQERKRVMQEACAKYRASSSRRAV
TPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHYGSALKRLDTFDRQGILHRLSTYTKMLFVREPFERLVS
AFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDAN

--------------------------------------------------------------
>In-frame_ENST00000260585_ENST00000438847_TCGA-20-1686_EPT1_chr2_26598016_+_CHST8_chr19_34262317_length(transcript)=2392nt_BP=801nt
CTCCTACCTTCTCGGGCAGCCCAGTCTTTGCCATCCTTGCCCAGCCGGTGTGGTGCTTGTGTGTCACAGCCTTGTAGCCGGGAGTCGCTG
CCGAGTGGGCGCTCAGTTTTCGGGTCGTCATGGCTGGCTACGAATACGTGAGCCCGGAGCAGCTGGCTGGCTTTGATAAGTACAAGTACA
GTGCTGTGGATACCAATCCACTTTCTCTGTATGTCATGCATCCATTCTGGAACACTATAGTAAAGGTATTTCCTACTTGGCTGGCGCCCA
ATCTGATAACTTTTTCTGGCTTTCTGCTGGTCGTATTCAATTTTCTGCTAATGGCATACTTTGATCCTGACTTTTATGCCTCAGCACCAG
GTCACAAGCACGTGCCTGACTGGGTTTGGATTGTAGTGGGCATCCTCAACTTCGTAGCCTACACTCTAGATGGTGTGGACGGAAAGCAAG
CTCGCAGAACCAATTCTAGCACTCCCTTAGGGGAGCTTTTTGATCATGGCCTGGATAGTTGGTCATGTGTTTACTTTGTTGTGACTGTTT
ATTCCATCTTTGGAAGAGGATCAACTGGTGTCAGTGTTTTTGTTCTTTATCTCCTGCTATGGGTAGTTTTGTTTTCTTTCATCCTGTCCC
ACTGGGAAAAGTATAACACAGGGATTCTTTTCCTGCCATGGGGATATGACATTAGCCAGGTGACTATTTCTTTTGTCTACATAGTGACTG
CAGTTGTGGGAGTTGAGGCCTGGTATGAACCTTTCCTGTTTAATTTCTTATATAGAGACCTATTCACTGCAATGATTATTGGAATAAAGT
TCAACATCAGGCCAAGGCAGCCCCACCACGACCTCCCACCAGGCGGCTCCCAGGATGGTGACTTGAAGGAACCCACAGAGAGGGTCACTC
GGGACTTATCCAGTGGGGCCCCGAGGGGCCGCAACCTGCCAGCGCCTGACCAGCCTCAACCCCCGCTGCAGAGGGGAACCCGTCTGCGGC
TCCGCCAGCGCCGTCGCCGTCTGCTCATCAAGAAAATGCCAGCTGCGGCGACCATCCCGGCCAACAGCTCGGACGCGCCCTTCATCCGGC
CGGGACCCGGGACGCTGGATGGCCGCTGGGTCAGCCTGCACCGGAGCCAGCAGGAGCGCAAGCGGGTGATGCAGGAGGCCTGCGCCAAGT
ACCGGGCGAGCAGCAGCCGCCGGGCCGTCACGCCCCGCCACGTGTCCCGTATCTTCGTGGAGGACCGCCACCGCGTGCTCTACTGCGAGG
TGCCCAAGGCCGGCTGCTCCAATTGGAAGCGGGTGCTCATGGTGCTGGCCGGCCTGGCCTCGTCCACTGCCGACATCCAGCACAACACCG
TCCACTATGGCAGCGCTCTCAAGCGCCTGGACACCTTCGACCGCCAGGGTATCTTGCACCGTCTCAGCACCTACACCAAGATGCTCTTTG
TCCGCGAGCCCTTCGAGAGGCTGGTGTCCGCCTTCCGCGACAAGTTTGAGCACCCCAACAGCTACTATCACCCGGTCTTCGGCAAGGCCA
TCCTGGCCCGGTACCGCGCCAATGCCTCTCGGGAGGCCCTGCGGACCGGCTCTGGGGTGCGTTTTCCCGAGTTCGTCCAGTACCTGCTGG
ACGTGCACCGGCCCGTGGGGATGGACATTCACTGGGACCATGTCAGCCGGCTCTGCAGCCCCTGCCTCATCGACTACGATTTCGTAGGCA
AGTTCGAGAGCATGGAGGACGATGCCAACTTCTTCCTGAGCCTCATCCGCGCGCCGCGGAACCTGACCTTCCCCCGGTTCAAGGACCGGC
ACTCGCAGGAGGCGCGGACCACAGCGAGGATCGCCCACCAGTACTTCGCCCAACTCTCGGCCCTGCAAAGGCAGCGCACCTACGACTTCT
ACTACATGGATTACCTGATGTTCAACTATTCCAAGCCCTTTGCAGATCTGTACTGAGGGGCGCCGCAGCTGGCCGGGGCCGCCCTGCCCC
GGTCACTCACCTGTGCTCCCGGGCATCCTCCTGTCCCTGGCTCCTCATCCTGGGAGCAACAGGGCTCTGAGGACGTGAGGAGCCATCGCT
GTGGGAGGCAGCAGGCCCCGGGTGGGGGGCAGAGGCGCCCAGCCTTGGATGGGGACCCCAGCCCCTGGCCTGTACCTGTTTCCTCATTCC
TTGGCTGAGGGAGAGGCTGAGAACTGGGCAGACACCCCTGGAGCTCAGCCGACAGTTTTGATGAGCAGGGAAGTCTGAGGCCCAGAGGAC
GGGGGGCCCAGCGGTAAGGGATGTCCCGCACTCCCTTAGCCATTGCCTTGGACCAAACCACGTGGTTTGCAGCTTTTCTACGAGCCAGGG

>In-frame_ENST00000260585_ENST00000438847_TCGA-20-1686_EPT1_chr2_26598016_+_CHST8_chr19_34262317_length(amino acids)=608AA_start in transcript=119_stop in transcript=1945
MAGYEYVSPEQLAGFDKYKYSAVDTNPLSLYVMHPFWNTIVKVFPTWLAPNLITFSGFLLVVFNFLLMAYFDPDFYASAPGHKHVPDWVW
IVVGILNFVAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGSTGVSVFVLYLLLWVVLFSFILSHWEKYNTGIL
FLPWGYDISQVTISFVYIVTAVVGVEAWYEPFLFNFLYRDLFTAMIIGIKFNIRPRQPHHDLPPGGSQDGDLKEPTERVTRDLSSGAPRG
RNLPAPDQPQPPLQRGTRLRLRQRRRRLLIKKMPAAATIPANSSDAPFIRPGPGTLDGRWVSLHRSQQERKRVMQEACAKYRASSSRRAV
TPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHYGSALKRLDTFDRQGILHRLSTYTKMLFVREPFERLVS
AFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDAN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EPT1-CHST8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EPT1-CHST8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EPT1-CHST8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHST8C4015729PEELING SKIN SYNDROME 31GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCHST8C4748093PEELING SKIN SYNDROME 61ORPHANET