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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ERBB2-PGAP3 (FusionGDB2 ID:27132) |
Fusion Gene Summary for ERBB2-PGAP3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ERBB2-PGAP3 | Fusion gene ID: 27132 | Hgene | Tgene | Gene symbol | ERBB2 | PGAP3 | Gene ID | 2064 | 93210 |
Gene name | erb-b2 receptor tyrosine kinase 2 | post-GPI attachment to proteins phospholipase 3 | |
Synonyms | CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1 | AGLA546|CAB2|PERLD1|PP1498|hCOS16 | |
Cytomap | 17q12 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2 | post-GPI attachment to proteins factor 3COS16 homologgene coamplified with ERBB2 proteinper1-like domain containing 1post-GPI attachment to proteins 3 | |
Modification date | 20200329 | 20200327 | |
UniProtAcc | P04626 | . | |
Ensembl transtripts involved in fusion gene | ENST00000584601, ENST00000406381, ENST00000541774, ENST00000445658, ENST00000540147, ENST00000584450, ENST00000269571, ENST00000578199, ENST00000540042, ENST00000584888, | ENST00000579146, ENST00000300658, ENST00000378011, ENST00000429199, | |
Fusion gene scores | * DoF score | 50 X 44 X 14=30800 | 9 X 8 X 6=432 |
# samples | 73 | 16 | |
** MAII score | log2(73/30800*10)=-5.39889007670225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/432*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ERBB2 [Title/Abstract] AND PGAP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ERBB2(37856564)-PGAP3(37830932), # samples:3 ERBB2(37856564)-PGAP3(37842272), # samples:3 PGAP3(37842175)-ERBB2(37844949), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | ERBB2-PGAP3 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ERBB2-PGAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ERBB2-PGAP3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PGAP3-ERBB2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. PGAP3-ERBB2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. PGAP3-ERBB2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ERBB2 | GO:0007165 | signal transduction | 10572067 |
Hgene | ERBB2 | GO:0007166 | cell surface receptor signaling pathway | 9685399 |
Hgene | ERBB2 | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 7514177 |
Hgene | ERBB2 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
Hgene | ERBB2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 12000754 |
Hgene | ERBB2 | GO:0032886 | regulation of microtubule-based process | 20937854 |
Hgene | ERBB2 | GO:0035556 | intracellular signal transduction | 19372587 |
Hgene | ERBB2 | GO:0042060 | wound healing | 12646923 |
Hgene | ERBB2 | GO:0043406 | positive regulation of MAP kinase activity | 10572067 |
Hgene | ERBB2 | GO:0045785 | positive regulation of cell adhesion | 7556068 |
Hgene | ERBB2 | GO:0046777 | protein autophosphorylation | 7556068 |
Hgene | ERBB2 | GO:0050679 | positive regulation of epithelial cell proliferation | 10572067 |
Hgene | ERBB2 | GO:0071363 | cellular response to growth factor stimulus | 20010870 |
Hgene | ERBB2 | GO:0090314 | positive regulation of protein targeting to membrane | 20010870 |
Fusion gene breakpoints across ERBB2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across PGAP3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | CESC | TCGA-Q1-A73R | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
ChimerDB4 | ESCA | TCGA-2H-A9GF | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
ChimerDB4 | ESCA | TCGA-2H-A9GF | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
ChimerDB4 | ESCA | TCGA-2H-A9GF | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
ChimerDB4 | ESCA | TCGA-2H-A9GF | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
ChimerDB4 | UCEC | TCGA-FI-A2F8 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
ChimerDB4 | ESCA | TCGA-2H-A9GF | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
ChimerDB4 | ESCA | TCGA-2H-A9GF | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
ChimerDB4 | ESCA | TCGA-2H-A9GF | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
ChimerDB4 | CESC | TCGA-Q1-A73R-01A | ERBB2 | chr17 | 37851434 | - | PGAP3 | chr17 | 37830932 | - |
ChimerDB4 | CESC | TCGA-Q1-A73R-01A | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
Top |
Fusion Gene ORF analysis for ERBB2-PGAP3 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000584601 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000584601 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000584601 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000584601 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000406381 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000406381 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000406381 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000406381 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000541774 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000541774 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000541774 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000541774 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000445658 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000445658 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000445658 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000445658 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540147 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540147 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540147 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540147 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584450 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584450 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584450 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584450 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000269571 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000269571 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000269571 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000269571 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000578199 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000578199 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000578199 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000578199 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540042 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540042 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540042 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540042 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584888 | ENST00000579146 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584888 | ENST00000300658 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584888 | ENST00000378011 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584888 | ENST00000429199 | ERBB2 | chr17 | 37851434 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584601 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584601 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584601 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584601 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000406381 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000406381 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000406381 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000406381 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000541774 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000541774 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000541774 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000541774 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000445658 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000445658 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000445658 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000445658 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000540147 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000540147 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000540147 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5UTR-intron | ENST00000540147 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000584450 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000584450 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000584450 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000584450 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000269571 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000269571 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000269571 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
5CDS-intron | ENST00000269571 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000578199 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000578199 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000578199 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000578199 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540042 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540042 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540042 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000540042 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584888 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584888 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584888 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-intron | ENST00000584888 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37830932 | - |
intron-3CDS | ENST00000584601 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584601 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584601 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584601 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000406381 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000406381 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000406381 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000406381 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000541774 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000541774 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000541774 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000541774 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000445658 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000445658 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000445658 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000445658 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
5UTR-3CDS | ENST00000540147 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
5UTR-3CDS | ENST00000540147 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
5UTR-3CDS | ENST00000540147 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
5UTR-3CDS | ENST00000540147 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584450 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584450 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584450 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584450 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000269571 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000269571 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000269571 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000269571 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000578199 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000578199 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000578199 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000578199 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000540042 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000540042 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000540042 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000540042 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584888 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584888 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584888 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584888 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584601 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584601 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584601 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584601 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000406381 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000406381 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000406381 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000406381 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000541774 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000541774 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000541774 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000541774 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000445658 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000445658 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000445658 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000445658 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000540147 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000540147 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000540147 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000540147 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584450 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584450 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584450 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000584450 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000269571 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000269571 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000269571 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000269571 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000578199 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000578199 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000578199 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000578199 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000540042 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000540042 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000540042 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
In-frame | ENST00000540042 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584888 | ENST00000579146 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584888 | ENST00000300658 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584888 | ENST00000378011 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584888 | ENST00000429199 | ERBB2 | chr17 | 37866734 | + | PGAP3 | chr17 | 37842272 | - |
intron-3CDS | ENST00000584601 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000584601 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000584601 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000584601 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000406381 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000406381 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000406381 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000406381 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000541774 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000541774 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000541774 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000541774 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
Frame-shift | ENST00000445658 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
Frame-shift | ENST00000445658 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5CDS-intron | ENST00000445658 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5CDS-intron | ENST00000445658 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5UTR-3CDS | ENST00000540147 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5UTR-3CDS | ENST00000540147 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5UTR-intron | ENST00000540147 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5UTR-intron | ENST00000540147 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
Frame-shift | ENST00000584450 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
Frame-shift | ENST00000584450 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5CDS-intron | ENST00000584450 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5CDS-intron | ENST00000584450 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
Frame-shift | ENST00000269571 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
Frame-shift | ENST00000269571 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5CDS-intron | ENST00000269571 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5CDS-intron | ENST00000269571 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000578199 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000578199 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000578199 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000578199 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000540042 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000540042 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000540042 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000540042 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000584888 | ENST00000579146 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-3CDS | ENST00000584888 | ENST00000300658 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000584888 | ENST00000378011 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
intron-intron | ENST00000584888 | ENST00000429199 | ERBB2 | chr17 | 37856564 | + | PGAP3 | chr17 | 37841002 | - |
5UTR-intron | ENST00000584601 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000584601 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000584601 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000584601 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000406381 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000406381 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000406381 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000406381 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000541774 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000541774 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000541774 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000541774 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000445658 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000445658 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000445658 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000445658 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000540147 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000540147 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000540147 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000540147 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000584450 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000584450 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000584450 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000584450 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000269571 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000269571 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000269571 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000269571 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000578199 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000578199 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000578199 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
5UTR-intron | ENST00000578199 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000540042 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000540042 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000540042 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000540042 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000584888 | ENST00000579146 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000584888 | ENST00000300658 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000584888 | ENST00000378011 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
intron-intron | ENST00000584888 | ENST00000429199 | ERBB2 | chr17 | 37851433 | + | PGAP3 | chr17 | 37830931 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ERBB2-PGAP3 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ERBB2-PGAP3 |
Go to FGviewer for the breakpoints of chr17:37856564-chr17:37842272 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ERBB2 | . |
FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 120_135 | 60.333333333333336 | 321.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 157_169 | 60.333333333333336 | 321.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 191_193 | 60.333333333333336 | 321.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 215_224 | 60.333333333333336 | 321.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 246_257 | 60.333333333333336 | 321.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 279_279 | 60.333333333333336 | 321.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 300_320 | 60.333333333333336 | 321.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 120_135 | 60.333333333333336 | 270.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 157_169 | 60.333333333333336 | 270.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 191_193 | 60.333333333333336 | 270.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 215_224 | 60.333333333333336 | 270.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 246_257 | 60.333333333333336 | 270.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 279_279 | 60.333333333333336 | 270.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 300_320 | 60.333333333333336 | 270.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 120_135 | 60.333333333333336 | 321.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 157_169 | 60.333333333333336 | 321.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 191_193 | 60.333333333333336 | 321.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 215_224 | 60.333333333333336 | 321.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 246_257 | 60.333333333333336 | 321.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 279_279 | 60.333333333333336 | 321.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 300_320 | 60.333333333333336 | 321.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 120_135 | 60.333333333333336 | 270.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 157_169 | 60.333333333333336 | 270.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 191_193 | 60.333333333333336 | 270.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 215_224 | 60.333333333333336 | 270.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 246_257 | 60.333333333333336 | 270.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 279_279 | 60.333333333333336 | 270.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 300_320 | 60.333333333333336 | 270.0 | Topological domain | Cytoplasmic | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 136_156 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 170_190 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 194_214 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 225_245 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 258_278 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 280_299 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 99_119 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 136_156 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 170_190 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 194_214 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 225_245 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 258_278 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 280_299 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 99_119 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 136_156 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 170_190 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 194_214 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 225_245 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 258_278 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 280_299 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 99_119 | 60.333333333333336 | 321.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 136_156 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 170_190 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 194_214 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 225_245 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 258_278 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 280_299 | 60.333333333333336 | 270.0 | Transmembrane | Helical | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 99_119 | 60.333333333333336 | 270.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000269571 | + | 1 | 27 | 720_987 | 24.333333333333332 | 1256.0 | Domain | Protein kinase |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000541774 | + | 1 | 27 | 720_987 | 0.0 | 1241.0 | Domain | Protein kinase |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000269571 | + | 7 | 27 | 720_987 | 300.3333333333333 | 1256.0 | Domain | Protein kinase |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000541774 | + | 7 | 27 | 720_987 | 285.3333333333333 | 1241.0 | Domain | Protein kinase |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000269571 | + | 1 | 27 | 676_689 | 24.333333333333332 | 1256.0 | Motif | Note=Nuclear localization signal |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000541774 | + | 1 | 27 | 676_689 | 0.0 | 1241.0 | Motif | Note=Nuclear localization signal |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000269571 | + | 7 | 27 | 676_689 | 300.3333333333333 | 1256.0 | Motif | Note=Nuclear localization signal |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000541774 | + | 7 | 27 | 676_689 | 285.3333333333333 | 1241.0 | Motif | Note=Nuclear localization signal |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000269571 | + | 1 | 27 | 726_734 | 24.333333333333332 | 1256.0 | Nucleotide binding | ATP |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000541774 | + | 1 | 27 | 726_734 | 0.0 | 1241.0 | Nucleotide binding | ATP |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000269571 | + | 7 | 27 | 726_734 | 300.3333333333333 | 1256.0 | Nucleotide binding | ATP |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000541774 | + | 7 | 27 | 726_734 | 285.3333333333333 | 1241.0 | Nucleotide binding | ATP |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000269571 | + | 1 | 27 | 23_652 | 24.333333333333332 | 1256.0 | Topological domain | Extracellular |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000269571 | + | 1 | 27 | 676_1255 | 24.333333333333332 | 1256.0 | Topological domain | Cytoplasmic |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000541774 | + | 1 | 27 | 23_652 | 0.0 | 1241.0 | Topological domain | Extracellular |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000541774 | + | 1 | 27 | 676_1255 | 0.0 | 1241.0 | Topological domain | Cytoplasmic |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000269571 | + | 7 | 27 | 23_652 | 300.3333333333333 | 1256.0 | Topological domain | Extracellular |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000269571 | + | 7 | 27 | 676_1255 | 300.3333333333333 | 1256.0 | Topological domain | Cytoplasmic |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000541774 | + | 7 | 27 | 23_652 | 285.3333333333333 | 1241.0 | Topological domain | Extracellular |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000541774 | + | 7 | 27 | 676_1255 | 285.3333333333333 | 1241.0 | Topological domain | Cytoplasmic |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000269571 | + | 1 | 27 | 653_675 | 24.333333333333332 | 1256.0 | Transmembrane | Helical |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000541774 | + | 1 | 27 | 653_675 | 0.0 | 1241.0 | Transmembrane | Helical |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000269571 | + | 7 | 27 | 653_675 | 300.3333333333333 | 1256.0 | Transmembrane | Helical |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000541774 | + | 7 | 27 | 653_675 | 285.3333333333333 | 1241.0 | Transmembrane | Helical |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000300658 | 0 | 8 | 21_98 | 60.333333333333336 | 321.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37856564 | chr17:37842272 | ENST00000378011 | 0 | 7 | 21_98 | 60.333333333333336 | 270.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000300658 | 0 | 8 | 21_98 | 60.333333333333336 | 321.0 | Topological domain | Lumenal | |
Tgene | PGAP3 | chr17:37866734 | chr17:37842272 | ENST00000378011 | 0 | 7 | 21_98 | 60.333333333333336 | 270.0 | Topological domain | Lumenal |
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Fusion Gene Sequence for ERBB2-PGAP3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for ERBB2-PGAP3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000269571 | + | 1 | 27 | 1195_1197 | 24.333333333333332 | 1256.0 | PIK3C2B |
Hgene | ERBB2 | chr17:37856564 | chr17:37842272 | ENST00000541774 | + | 1 | 27 | 1195_1197 | 0.0 | 1241.0 | PIK3C2B |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000269571 | + | 7 | 27 | 1195_1197 | 300.3333333333333 | 1256.0 | PIK3C2B |
Hgene | ERBB2 | chr17:37866734 | chr17:37842272 | ENST00000541774 | + | 7 | 27 | 1195_1197 | 285.3333333333333 | 1241.0 | PIK3C2B |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ERBB2-PGAP3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ERBB2 | P04626 | DB06366 | Pertuzumab | Inhibitor | Biotech | Approved |
Hgene | ERBB2 | P04626 | DB06366 | Pertuzumab | Inhibitor | Biotech | Approved |
Hgene | ERBB2 | P04626 | DB06366 | Pertuzumab | Inhibitor | Biotech | Approved |
Hgene | ERBB2 | P04626 | DB06366 | Pertuzumab | Inhibitor | Biotech | Approved |
Hgene | ERBB2 | P04626 | DB06366 | Pertuzumab | Inhibitor | Biotech | Approved |
Hgene | ERBB2 | P04626 | DB08916 | Afatinib | Inhibitor | Small molecule | Approved |
Hgene | ERBB2 | P04626 | DB08916 | Afatinib | Inhibitor | Small molecule | Approved |
Hgene | ERBB2 | P04626 | DB08916 | Afatinib | Inhibitor | Small molecule | Approved |
Hgene | ERBB2 | P04626 | DB08916 | Afatinib | Inhibitor | Small molecule | Approved |
Hgene | ERBB2 | P04626 | DB08916 | Afatinib | Inhibitor | Small molecule | Approved |
Hgene | ERBB2 | P04626 | DB00072 | Trastuzumab | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB00072 | Trastuzumab | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB00072 | Trastuzumab | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB00072 | Trastuzumab | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB00072 | Trastuzumab | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB01259 | Lapatinib | Antagonist | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB01259 | Lapatinib | Antagonist | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB01259 | Lapatinib | Antagonist | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB01259 | Lapatinib | Antagonist | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB01259 | Lapatinib | Antagonist | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB05773 | Trastuzumab emtansine | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB05773 | Trastuzumab emtansine | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB05773 | Trastuzumab emtansine | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB05773 | Trastuzumab emtansine | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB05773 | Trastuzumab emtansine | Antibody | Biotech | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB11652 | Tucatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB11652 | Tucatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB11652 | Tucatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB11652 | Tucatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB11652 | Tucatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12267 | Brigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12267 | Brigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12267 | Brigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12267 | Brigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB12267 | Brigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB15035 | Zanubrutinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB15035 | Zanubrutinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB15035 | Zanubrutinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB15035 | Zanubrutinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | ERBB2 | P04626 | DB15035 | Zanubrutinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for ERBB2-PGAP3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ERBB2 | C0006142 | Malignant neoplasm of breast | 40 | CGI;CTD_human |
Hgene | ERBB2 | C0678222 | Breast Carcinoma | 40 | CGI;CTD_human |
Hgene | ERBB2 | C1257931 | Mammary Neoplasms, Human | 40 | CTD_human |
Hgene | ERBB2 | C1458155 | Mammary Neoplasms | 40 | CTD_human |
Hgene | ERBB2 | C4704874 | Mammary Carcinoma, Human | 40 | CTD_human |
Hgene | ERBB2 | C1140680 | Malignant neoplasm of ovary | 4 | CGI;CTD_human;UNIPROT |
Hgene | ERBB2 | C0024623 | Malignant neoplasm of stomach | 3 | CGI;CTD_human |
Hgene | ERBB2 | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
Hgene | ERBB2 | C0038356 | Stomach Neoplasms | 3 | CGI;CTD_human |
Hgene | ERBB2 | C0235874 | Disease Exacerbation | 3 | CTD_human |
Hgene | ERBB2 | C0376358 | Malignant neoplasm of prostate | 3 | CTD_human |
Hgene | ERBB2 | C1708349 | Hereditary Diffuse Gastric Cancer | 3 | CTD_human |
Hgene | ERBB2 | C0001418 | Adenocarcinoma | 2 | CTD_human |
Hgene | ERBB2 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
Hgene | ERBB2 | C0205641 | Adenocarcinoma, Basal Cell | 2 | CTD_human |
Hgene | ERBB2 | C0205642 | Adenocarcinoma, Oxyphilic | 2 | CTD_human |
Hgene | ERBB2 | C0205643 | Carcinoma, Cribriform | 2 | CTD_human |
Hgene | ERBB2 | C0205644 | Carcinoma, Granular Cell | 2 | CTD_human |
Hgene | ERBB2 | C0205645 | Adenocarcinoma, Tubular | 2 | CTD_human |
Hgene | ERBB2 | C0699791 | Stomach Carcinoma | 2 | CGI;UNIPROT |
Hgene | ERBB2 | C0919267 | ovarian neoplasm | 2 | CGI;CTD_human |
Hgene | ERBB2 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
Hgene | ERBB2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ERBB2 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | ERBB2 | C0013930 | Embolism, Tumor | 1 | CTD_human |
Hgene | ERBB2 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | ERBB2 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
Hgene | ERBB2 | C0017185 | Gastrointestinal Neoplasms | 1 | CTD_human |
Hgene | ERBB2 | C0021367 | Mammary Ductal Carcinoma | 1 | CTD_human |
Hgene | ERBB2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | ERBB2 | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
Hgene | ERBB2 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ERBB2 | C0025149 | Medulloblastoma | 1 | CTD_human |
Hgene | ERBB2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | ERBB2 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
Hgene | ERBB2 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | ERBB2 | C0030354 | Papilloma | 1 | CTD_human |
Hgene | ERBB2 | C0153452 | Malignant neoplasm of gallbladder | 1 | CTD_human |
Hgene | ERBB2 | C0205833 | Medullomyoblastoma | 1 | CTD_human |
Hgene | ERBB2 | C0205874 | Papilloma, Squamous Cell | 1 | CTD_human |
Hgene | ERBB2 | C0205875 | Papillomatosis | 1 | CTD_human |
Hgene | ERBB2 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Hgene | ERBB2 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Hgene | ERBB2 | C0278510 | Childhood Medulloblastoma | 1 | CTD_human |
Hgene | ERBB2 | C0278876 | Adult Medulloblastoma | 1 | CTD_human |
Hgene | ERBB2 | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ERBB2 | C0345905 | Intrahepatic Cholangiocarcinoma | 1 | CTD_human |
Hgene | ERBB2 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
Hgene | ERBB2 | C0596263 | Carcinogenesis | 1 | CTD_human |
Hgene | ERBB2 | C0684249 | Carcinoma of lung | 1 | UNIPROT |
Hgene | ERBB2 | C0685938 | Malignant neoplasm of gastrointestinal tract | 1 | CTD_human |
Hgene | ERBB2 | C0751291 | Desmoplastic Medulloblastoma | 1 | CTD_human |
Hgene | ERBB2 | C1134719 | Invasive Ductal Breast Carcinoma | 1 | CTD_human |
Hgene | ERBB2 | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
Hgene | ERBB2 | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ERBB2 | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ERBB2 | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human |
Hgene | ERBB2 | C1275668 | Melanotic medulloblastoma | 1 | CTD_human |
Hgene | ERBB2 | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human |
Hgene | ERBB2 | C1368275 | Pigmented Basal Cell Carcinoma | 1 | CTD_human |
Hgene | ERBB2 | C2750850 | GLIOMA SUSCEPTIBILITY 1 | 1 | UNIPROT |
Hgene | ERBB2 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
Hgene | ERBB2 | C3805278 | Extrahepatic Cholangiocarcinoma | 1 | CTD_human |
Hgene | ERBB2 | C4721610 | Carcinoma, Ovarian Epithelial | 1 | CTD_human |
Hgene | ERBB2 | C4721806 | Carcinoma, Basal Cell | 1 | CTD_human |
Tgene | PGAP3 | C1855923 | Hyperphosphatasia with Mental Retardation | 1 | CTD_human;ORPHANET |
Tgene | PGAP3 | C3810354 | HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 4 | 1 | GENOMICS_ENGLAND;UNIPROT |