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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ERBB3-CSN2 (FusionGDB2 ID:27174) |
Fusion Gene Summary for ERBB3-CSN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ERBB3-CSN2 | Fusion gene ID: 27174 | Hgene | Tgene | Gene symbol | ERBB3 | CSN2 | Gene ID | 2065 | 9318 |
| Gene name | erb-b2 receptor tyrosine kinase 3 | COP9 signalosome subunit 2 | |
| Synonyms | ErbB-3|FERLK|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 | ALIEN|CSN2|SGN2|TRIP15 | |
| Cytomap | 12q13.2 | 15q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | COP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | P21860 | P05814 | |
| Ensembl transtripts involved in fusion gene | ENST00000267101, ENST00000450146, ENST00000415288, ENST00000553131, ENST00000411731, ENST00000549832, | ENST00000353151, | |
| Fusion gene scores | * DoF score | 16 X 18 X 11=3168 | 14 X 12 X 2=336 |
| # samples | 19 | 3 | |
| ** MAII score | log2(19/3168*10)=-4.05950101174866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/336*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ERBB3 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ERBB3(56496111)-CSN2(70826725), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ERBB3 | GO:0007162 | negative regulation of cell adhesion | 7556068 |
| Hgene | ERBB3 | GO:0007165 | signal transduction | 10572067 |
| Hgene | ERBB3 | GO:0009968 | negative regulation of signal transduction | 11389077 |
| Hgene | ERBB3 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
| Hgene | ERBB3 | GO:0042127 | regulation of cell proliferation | 11389077 |
| Hgene | ERBB3 | GO:0051048 | negative regulation of secretion | 10559227 |
| Tgene | CSN2 | GO:0000338 | protein deneddylation | 19141280 |
| Tgene | CSN2 | GO:0006468 | protein phosphorylation | 9535219 |
| Fusion gene breakpoints across ERBB3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CSN2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-AO-A1KO-01A | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
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Fusion Gene ORF analysis for ERBB3-CSN2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000267101 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
| 3UTR-3CDS | ENST00000450146 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
| 3UTR-3CDS | ENST00000415288 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
| 3UTR-3CDS | ENST00000553131 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
| intron-3CDS | ENST00000411731 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
| 3UTR-3CDS | ENST00000549832 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ERBB3-CSN2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ERBB3-CSN2 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERBB3 | CSN2 |
| FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:27416908}. | FUNCTION: Important role in determination of the surface properties of the casein micelles. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ERBB3-CSN2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for ERBB3-CSN2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ERBB3-CSN2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ERBB3 | P21860 | DB11652 | Tucatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | ERBB3 | P21860 | DB11652 | Tucatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for ERBB3-CSN2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ERBB3 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Hgene | ERBB3 | C1843478 | Lethal Congenital Contracture Syndrome 2 | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Hgene | ERBB3 | C0006142 | Malignant neoplasm of breast | 2 | CTD_human |
| Hgene | ERBB3 | C0678222 | Breast Carcinoma | 2 | CTD_human |
| Hgene | ERBB3 | C1257931 | Mammary Neoplasms, Human | 2 | CTD_human |
| Hgene | ERBB3 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
| Hgene | ERBB3 | C4704874 | Mammary Carcinoma, Human | 2 | CTD_human |
| Hgene | ERBB3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | ERBB3 | C0011570 | Mental Depression | 1 | PSYGENET |
| Hgene | ERBB3 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
| Hgene | ERBB3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | ERBB3 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | ERBB3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | ERBB3 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | ERBB3 | C0153452 | Malignant neoplasm of gallbladder | 1 | CTD_human |
| Hgene | ERBB3 | C0235874 | Disease Exacerbation | 1 | CTD_human |
| Hgene | ERBB3 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
| Hgene | ERBB3 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Hgene | ERBB3 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Hgene | ERBB3 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
| Hgene | ERBB3 | C4746575 | ERYTHROLEUKEMIA, FAMILIAL, SUSCEPTIBILITY TO | 1 | UNIPROT |
| Tgene | CSN2 | C0007097 | Carcinoma | 2 | CTD_human |
| Tgene | CSN2 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Tgene | CSN2 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
| Tgene | CSN2 | C0205696 | Anaplastic carcinoma | 2 | CTD_human |
| Tgene | CSN2 | C0205697 | Carcinoma, Spindle-Cell | 2 | CTD_human |
| Tgene | CSN2 | C0205698 | Undifferentiated carcinoma | 2 | CTD_human |
| Tgene | CSN2 | C0205699 | Carcinomatosis | 2 | CTD_human |
| Tgene | CSN2 | C1257925 | Mammary Carcinoma, Animal | 2 | CTD_human |
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