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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ERC1-VWF (FusionGDB2 ID:27249) |
Fusion Gene Summary for ERC1-VWF |
Fusion gene summary |
Fusion gene information | Fusion gene name: ERC1-VWF | Fusion gene ID: 27249 | Hgene | Tgene | Gene symbol | ERC1 | VWF | Gene ID | 23085 | 7450 |
Gene name | ELKS/RAB6-interacting/CAST family member 1 | von Willebrand factor | |
Synonyms | Cast2|ELKS|ERC-1|RAB6IP2 | F8VWF|VWD | |
Cytomap | 12p13.33 | 12p13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | ELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2 | von Willebrand factorcoagulation factor VIII VWF | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | Q8IUD2 | . | |
Ensembl transtripts involved in fusion gene | ENST00000543086, ENST00000546231, ENST00000397203, ENST00000360905, ENST00000589028, ENST00000355446, ENST00000536573, | ENST00000261405, ENST00000572068, ENST00000545906, | |
Fusion gene scores | * DoF score | 32 X 23 X 16=11776 | 4 X 4 X 3=48 |
# samples | 38 | 5 | |
** MAII score | log2(38/11776*10)=-4.95370634772607 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ERC1 [Title/Abstract] AND VWF [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ERC1(1372331)-VWF(6085426), # samples:4 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ERC1 | GO:0007252 | I-kappaB phosphorylation | 15218148 |
Tgene | VWF | GO:0007155 | cell adhesion | 10764791 |
Tgene | VWF | GO:0030168 | platelet activation | 8565074 |
Tgene | VWF | GO:0031589 | cell-substrate adhesion | 9079671 |
Fusion gene breakpoints across ERC1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across VWF (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-05-4415-01A | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
ChimerDB4 | LUAD | TCGA-05-4415 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
ChimerDB4 | LUAD | TCGA-05-4415-01A | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
ChimerDB4 | LUAD | TCGA-05-4415-01A | ERC1 | chr12 | 1372331 | - | VWF | chr12 | 6085426 | - |
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Fusion Gene ORF analysis for ERC1-VWF |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000543086 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000543086 | ENST00000572068 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000543086 | ENST00000545906 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
In-frame | ENST00000546231 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000546231 | ENST00000572068 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000546231 | ENST00000545906 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
In-frame | ENST00000397203 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000397203 | ENST00000572068 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000397203 | ENST00000545906 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
In-frame | ENST00000360905 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000360905 | ENST00000572068 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000360905 | ENST00000545906 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
In-frame | ENST00000589028 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000589028 | ENST00000572068 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000589028 | ENST00000545906 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
In-frame | ENST00000355446 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000355446 | ENST00000572068 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
5CDS-intron | ENST00000355446 | ENST00000545906 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
intron-3CDS | ENST00000536573 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
intron-intron | ENST00000536573 | ENST00000572068 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
intron-intron | ENST00000536573 | ENST00000545906 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000543086 | ERC1 | chr12 | 1372331 | + | ENST00000261405 | VWF | chr12 | 6085426 | - | 4102 | 2806 | 271 | 3960 | 1229 |
ENST00000546231 | ERC1 | chr12 | 1372331 | + | ENST00000261405 | VWF | chr12 | 6085426 | - | 4455 | 3159 | 528 | 4313 | 1261 |
ENST00000397203 | ERC1 | chr12 | 1372331 | + | ENST00000261405 | VWF | chr12 | 6085426 | - | 4321 | 3025 | 406 | 4179 | 1257 |
ENST00000360905 | ERC1 | chr12 | 1372331 | + | ENST00000261405 | VWF | chr12 | 6085426 | - | 4096 | 2800 | 181 | 3954 | 1257 |
ENST00000589028 | ERC1 | chr12 | 1372331 | + | ENST00000261405 | VWF | chr12 | 6085426 | - | 4072 | 2776 | 157 | 3930 | 1257 |
ENST00000355446 | ERC1 | chr12 | 1372331 | + | ENST00000261405 | VWF | chr12 | 6085426 | - | 4047 | 2751 | 132 | 3905 | 1257 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000543086 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - | 0.002907071 | 0.99709296 |
ENST00000546231 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - | 0.005831752 | 0.9941683 |
ENST00000397203 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - | 0.002493654 | 0.9975063 |
ENST00000360905 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - | 0.002180164 | 0.9978198 |
ENST00000589028 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - | 0.001920698 | 0.9980793 |
ENST00000355446 | ENST00000261405 | ERC1 | chr12 | 1372331 | + | VWF | chr12 | 6085426 | - | 0.002025448 | 0.9979746 |
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Fusion Genomic Features for ERC1-VWF |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ERC1-VWF |
Go to FGviewer for the breakpoints of chr12:1372331-chr12:6085426 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ERC1 | . |
FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 2429_2495 | 2429.0 | 2814.0 | Domain | VWFC 2 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 2580_2645 | 2429.0 | 2814.0 | Domain | VWFC 3 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 2724_2812 | 2429.0 | 2814.0 | Domain | CTCK | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 2507_2509 | 2429.0 | 2814.0 | Motif | Note=Cell attachment site |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000360905 | + | 14 | 19 | 1060_1100 | 873.0 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000360905 | + | 14 | 19 | 144_988 | 873.0 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000397203 | + | 14 | 19 | 1060_1100 | 873.0 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000397203 | + | 14 | 19 | 144_988 | 873.0 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000543086 | + | 13 | 18 | 1060_1100 | 845.0 | 1089.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000543086 | + | 13 | 18 | 144_988 | 845.0 | 1089.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000589028 | + | 13 | 18 | 1060_1100 | 873.0 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000589028 | + | 13 | 18 | 144_988 | 873.0 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000360905 | + | 14 | 19 | 1046_1108 | 873.0 | 1117.0 | Domain | FIP-RBD |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000397203 | + | 14 | 19 | 1046_1108 | 873.0 | 1117.0 | Domain | FIP-RBD |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000543086 | + | 13 | 18 | 1046_1108 | 845.0 | 1089.0 | Domain | FIP-RBD |
Hgene | ERC1 | chr12:1372331 | chr12:6085426 | ENST00000589028 | + | 13 | 18 | 1046_1108 | 873.0 | 1117.0 | Domain | FIP-RBD |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 1146_1196 | 2429.0 | 2814.0 | Domain | Note=TIL 4 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 1277_1453 | 2429.0 | 2814.0 | Domain | VWFA 1%3B binding site for platelet glycoprotein Ib | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 1498_1665 | 2429.0 | 2814.0 | Domain | VWFA 2 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 1691_1871 | 2429.0 | 2814.0 | Domain | VWFA 3%3B main binding site for collagens type I and III | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 1949_2153 | 2429.0 | 2814.0 | Domain | VWFD 4 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 2255_2328 | 2429.0 | 2814.0 | Domain | VWFC 1 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 295_348 | 2429.0 | 2814.0 | Domain | Note=TIL 1 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 34_240 | 2429.0 | 2814.0 | Domain | VWFD 1 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 387_598 | 2429.0 | 2814.0 | Domain | VWFD 2 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 652_707 | 2429.0 | 2814.0 | Domain | Note=TIL 2 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 776_827 | 2429.0 | 2814.0 | Domain | Note=TIL 3 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 866_1074 | 2429.0 | 2814.0 | Domain | VWFD 3 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 2216_2261 | 2429.0 | 2814.0 | Region | Note=E2 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 764_787 | 2429.0 | 2814.0 | Region | Note=Amino-terminal | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 788_833 | 2429.0 | 2814.0 | Region | Note=E1 | |
Tgene | VWF | chr12:1372331 | chr12:6085426 | ENST00000261405 | 41 | 52 | 826_853 | 2429.0 | 2814.0 | Region | Note=CX |
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Fusion Gene Sequence for ERC1-VWF |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000543086_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(transcript)=4102nt_BP=2806nt GGGCGCGGTGACGTCGCGGGCGCCTGGGCCGTGCTGTGGCGGCGGCGGCGGCGGTAGTGGCGGCGGCGGCGGTGCCTGGGCGGCAGCAGC AGCAGTAGCGGCAGCCCTGAGGACGATATGGTGTAAGATACTTCTTCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACC AACTTGTAGCCATAGAGACACCTCACAAGGTTCCCATTTTTGTTGTTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAAC CATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTT GGGTCACCGTCGAACCAACAGTACGGGAGGGAGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACA ATCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGAC ACTTGGCCGTTCTGGGGGACGTCTGCCTTACGGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAG TGACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACAC AATCATGGATCTGCAGACACAGCTGAAGGAAGTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAG TTCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCAT TTGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAG GGACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCT TCATGCTGAGCATGAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCA GACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCA TGAGAGAACAAGACGACTGGCAGAGGCAGAGATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTT GAGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAA AATTTCCTCTATGGAGCGTGGGCTTCGAGACCTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGA AGAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATTTATGAAAAATAAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAA GGACACAGAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGA GTCCTTGACTGCTAAGGAGCAGAGGGCTGCCATCCTGCAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTT GAATAAAAAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGT GAAGGAGCGGAAGGTTAATGTTCTTCAGAAGAAGATTGAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAA AGAACGGGTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTTGACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGAC AATTGAACGCTTAAAGGAGCAGAGGGACAGAGATGAGCGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAA GGAAAAAGTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTC AGGACTGAAAAAGGACTCACGGCTTAAGACACTAGAGATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAA AAAGGCACATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAA AGATGAATCTAGCAAGGCCCAGGCAGAAGTTGATCGACTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAA GATAGCTGAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGC ACAAATGTTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAG GATTGAAGAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGAC CAATGCTGAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCAC CGACATGGAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGT TCTGCATGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTG GAAGAGTGTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACA AAGGAACGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTG TCGCTGTGAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCG CTGCATGGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGA AAATAACACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGA TGAGACGCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCC ACCCTTTGATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTG CAACGACATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATG TGCCAGCAAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGT GGCCCTGCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTG AGGCTGCTGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGGCCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTC >In-frame_ENST00000543086_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(amino acids)=1229AA_start in transcript=271_stop in transcript=3960 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR IEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAVMGLRVAQCSQKPCEDSCRSGFTYV LHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSC RCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGECCGRCLPTACTIQLRGGQIMTLKRD ETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKC -------------------------------------------------------------- >In-frame_ENST00000546231_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(transcript)=4455nt_BP=3159nt GGGCCGTGCTGTGGCGGCGGCGGCGGCGGTAGTGGCGGCGGCGGCGGTGCCTGGGCGGCAGCAGCAGCAGTAGCGGCAGCCCTGAGGACG GTGAGACGGCCGCGGCGGCGGCGACAGCGCGGAAGTCGCGCGGGACCCAGAGCTTCCCCCCTGTCGCTAGTGCTGAGGCTTTCGCCTTTC CTACCCAGCTTCTTGCTCACGGCCCGGGCTGGGCTGGGCAGGGCAACGCGCCCCCGGGGAGGGGCGGAGCTGTAGGTTGGTCTTGAACTC CTGGCCTCAAGCGATCTTCCTACCTTGGCCTCCCAGAGCGCTGGGATTATAGGCATGAGCCATTGCACTTGGCACTTTTTTTGTTTGTTT TCCAGTTGCATGATATGGTGTAAGATACTTCTTCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACCAACTTGTAGCCAT AGAGACACCTCACAAGGTTCCCATTTTTGTTGTTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAACCATGTATGGAAGT GCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGA ACCAACAGTACGGGAGGGAGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAATCTTTAAATGCT GCCTATGCCACCTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCT GGGGGACGTCTGCCTTACGGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGTGACACCATAGCA TTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTG CAGACACAGCTGAAGGAAGTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGTTCTTCAATGAAT AGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAG TACAGAGTTGTACAGGAGGAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGGGACCTGAATCAG CTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCAT GAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAGACCCTAAATGCT CGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGA CGACTGGCAGAGGCAGAGATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTGAGAGAGGAGATG CATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATG GAGCGTGGGCTTCGAGACCTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAAGAAGAAATGAAG CAAATGGAAGTGTATCGGAGCCATTCTAAATTTATGAAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGG GAGGAGCTGAAAAAGAAAGCGGCTGGTCTTCAGGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACAGAACTACTCGCC CTGCAGACAAAGCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAG CAGAGGGCTGCCATCCTGCAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAAAAGACAAAACAA ATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAAT GTTCTTCAGAAGAAGATTGAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGGGTCAAATCCTTG CAGGCTGACACCACCAACACTGACACTGCCTTGACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAG CAGAGGGACAGAGATGAGCGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAAGTCAGCCTGTTG CAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCA CGGCTTAAGACACTAGAGATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCACATGAGGCAGCA TTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCC CAGGCAGAAGTTGATCGACTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCTGAGTTGGAAAGT CTCACCTCAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAATG TTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAA GAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGCT GAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATG GAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCAT GAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGT GTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAAC GTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGT GAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCATG GTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAAC ACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGACG CTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTT GATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGAC ATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGC AAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCTG CACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTGC TGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGGCCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTCTTGTGCC >In-frame_ENST00000546231_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(amino acids)=1261AA_start in transcript=528_stop in transcript=4313 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK SAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCT CTDMEDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFI QQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYK EENNTGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEP ECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMYSIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCS -------------------------------------------------------------- >In-frame_ENST00000397203_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(transcript)=4321nt_BP=3025nt GTGCTGTGGCGGCGGCGGCGGCGGTAGTGGCGGCGGCGGCGGTGCCTGGGCGGCAGCAGCAGCAGTAGCGGCAGCCCTGAGGACGGTGAG ACGGCCGCGGCGGCGGCGACAGCGCGGAAGTCGCGCGGGACCCAGAGCTTCCCCCCTGTCGCTAGTGCTGAGGCTTTCGCCTTTCCTACC CAGCTTCTTGCTCACGGCCCGGGCTGGGCTGGGCAGGGCAACGCGCCCCCGGGGAGGGGCGGAGCTGTAGATATGGTGTAAGATACTTCT TCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACCAACTTGTAGCCATAGAGACACCTCACAAGGTTCCCATTTTTGTTG TTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAACCATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAG CCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGAACCAACAGTACGGGAGGGAGTTCGGGAAGCAG TGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAATCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAG TGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCTGGGGGACGTCTGCCTTACGGTGTTCGGATGAC TGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGTGACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTAT GGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTGCAGACACAGCTGAAGGAAGTATTAAGAGAAAA TGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGTTCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAA GAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCACAT GCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGGGACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGG CGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCATGAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCG AAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAGACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAAT GTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGACGACTGGCAGAGGCAGAGATGCACGTTCATCA CCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTGAGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGC CAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATGGAGCGTGGGCTTCGAGACCTGGAAGAGGAAAT TCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAAGAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATT TATGAAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGGGAGGAGCTGAAAAAGAAAGCGGCTGGTCTTCA GGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACAGAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCA GTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAGCAGAGGGCTGCCATCCTGCAGACTGAGGTGGA TGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAAAAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACA AGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAATGTTCTTCAGAAGAAGATTGAAAATCTTCAAGA GCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGGGTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTT GACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAGCAGAGGGACAGAGATGAGCGAGAGAAGCAAGA GGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAAGTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACT TTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCACGGCTTAAGACACTAGAGATTGCTTTGGAGCA GAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCACATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGA CCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCCCAGGCAGAAGTTGATCGACTCTTAGAAATCTT GAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCTGAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAA TCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAATGTTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTC TCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAAGAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGA GCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGCTGAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGG CCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATGGAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAA GCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCATGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGT GGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGTGTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAA TGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAACGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTT TCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGTGAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCC CGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCATGGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAA GACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAACACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCAT TCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGACGCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAG AGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTTGATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAAT TCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGACATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTC TGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGCAAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTG CTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCTGCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGC CATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTGCTGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGG CCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTCTTGTGCCCTTCTGAGCCCACAATAAAGGCTGAGCTCTTATCTTGCAAAAGG >In-frame_ENST00000397203_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(amino acids)=1257AA_start in transcript=406_stop in transcript=4179 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDM EDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRN VSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENN TGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECND -------------------------------------------------------------- >In-frame_ENST00000360905_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(transcript)=4096nt_BP=2800nt AGCAGTAGCGGCAGCCCTGAGGACGATATGGTGTAAGATACTTCTTCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACC AACTTGTAGCCATAGAGACACCTCACAAGGTTCCCATTTTTGTTGTTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAAC CATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTT GGGTCACCGTCGAACCAACAGTACGGGAGGGAGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACA ATCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGAC ACTTGGCCGTTCTGGGGGACGTCTGCCTTACGGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAG TGACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACAC AATCATGGATCTGCAGACACAGCTGAAGGAAGTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAG TTCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCAT TTGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAG GGACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCT TCATGCTGAGCATGAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCA GACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCA TGAGAGAACAAGACGACTGGCAGAGGCAGAGATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTT GAGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAA AATTTCCTCTATGGAGCGTGGGCTTCGAGACCTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGA AGAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATTTATGAAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAA AGAGGCTCAATGGGAGGAGCTGAAAAAGAAAGCGGCTGGTCTTCAGGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACAC AGAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTT GACTGCTAAGGAGCAGAGGGCTGCCATCCTGCAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAA AAAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGA GCGGAAGGTTAATGTTCTTCAGAAGAAGATTGAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACG GGTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTTGACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGA ACGCTTAAAGGAGCAGAGGGACAGAGATGAGCGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAA AGTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACT GAAAAAGGACTCACGGCTTAAGACACTAGAGATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGC ACATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGA ATCTAGCAAGGCCCAGGCAGAAGTTGATCGACTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGC TGAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAAT GTTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGA AGAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGC TGAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACAT GGAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCA TGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAG TGTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAA CGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTG TGAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCAT GGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAA CACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGAC GCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTT TGATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGA CATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAG CAAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCT GCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTG CTGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGGCCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTCTTGTGC >In-frame_ENST00000360905_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(amino acids)=1257AA_start in transcript=181_stop in transcript=3954 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDM EDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRN VSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENN TGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECND -------------------------------------------------------------- >In-frame_ENST00000589028_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(transcript)=4072nt_BP=2776nt GATATGGTGTAAGATACTTCTTCAAGATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACCAACTTGTAGCCATAGAGACACCTC ACAAGGTTCCCATTTTTGTTGTTGTTGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAACCATGTATGGAAGTGCCCGCTCTGT TGGGAAGGTGGAGCCGAGCAGCCAGAGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGAACCAACAGTAC GGGAGGGAGTTCGGGAAGCAGTGTTGGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAATCTTTAAATGCTGCCTATGCCAC CTCTGGCCCTATGTATCTAAGTGACCATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCTGGGGGACGTCT GCCTTACGGTGTTCGGATGACTGCTATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGTGACACCATAGCATTTGGAGAGCA TCACCTCCCTCCTGTGAGTATGGCATCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTGCAGACACAGCT GAAGGAAGTATTAAGAGAAAATGATCTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGTTCTTCAATGAATAGCATCAAGAC CTTCTGGAGCCCAGAGCTGAAGAAGGAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAGTACAGAGTTGT ACAGGAGGAAAACCAGCACATGCAGATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGGGACCTGAATCAGCTGTTTCAGCA GGATAGTAGCAGCAGGACTGGCGAACCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCATGAGCGGCAGGC CAAAGAGCTGTTTCTTCTTCGAAAGACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAGACCCTAAATGCTCGGGATGAATC CATTAAGAAGCTTCTGGAAATGTTGCAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGACGACTGGCAGA GGCAGAGATGCACGTTCATCACCTAGAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTGAGAGAGGAGATGCATCGAAGGTT TGAGAATGCTCCTGATTCTGCCAAAACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATGGAGCGTGGGCT TCGAGACCTGGAAGAGGAAATTCAGATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAAGAAGAAATGAAGCAAATGGAAGT GTATCGGAGCCATTCTAAATTTATGAAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGGGAGGAGCTGAA AAAGAAAGCGGCTGGTCTTCAGGCTGAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACAGAACTACTCGCCCTGCAGACAAA GCTAGAAACACTCACAAACCAGTTCTCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAGCAGAGGGCTGC CATCCTGCAGACTGAGGTGGATGCTCTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAAAAGACAAAACAAATTCAGGATAT GGCTGAAGAGAAGGGGACACAAGCTGGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAATGTTCTTCAGAA GAAGATTGAAAATCTTCAAGAGCAGCTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGGGTCAAATCCTTGCAGGCTGACAC CACCAACACTGACACTGCCTTGACAACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAGCAGAGGGACAG AGATGAGCGAGAGAAGCAAGAGGAAATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAAGTCAGCCTGTTGCAAGGCGACCT TTCAGAGAAAGAGGCTTCACTTTTGGATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCACGGCTTAAGAC ACTAGAGATTGCTTTGGAGCAGAAGAAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCACATGAGGCAGCATTGGAAGCCAG AGCCAGTCCAGAGATGAGTGACCGAATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCCCAGGCAGAAGT TGATCGACTCTTAGAAATCTTGAAGGAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCTGAGTTGGAAAGGCAAGTGAAAGA CCAGAATAAGAAGGTAGCAAATCTGAAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAATGTTAGAGGAGGCGCGACGACGGGA GGACAATCTCAACGACAGCTCTCAGCAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAAGAGCTGGAAGAAGCACTAAGAGA AAGTGTACAGATAACTGCAGAGCGGGAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGCTGAAAAACAGGTGTGTGTCCACCG AAGCACCATCTACCCTGTGGGCCAGTTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATGGAGGATGCCGTGATGGGCCTCCG CGTGGCCCAGTGCTCCCAGAAGCCCTGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCATGAAGGCGAGTGCTGTGGAAGGTG CCTGCCATCTGCCTGTGAGGTGGTGACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGTGTCGGCTCCCAGTGGGCCTCCCC GGAGAACCCCTGCCTCATCAATGAGTGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAACGTCTCCTGCCCCCAGCTGGAGGT CCCTGTCTGCCCCTCGGGCTTTCAGCTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGTGAGCGCATGGAGGCCTGCATGCT CAATGGCACTGTCATTGGGCCCGGGAAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCATGGTGCAGGTGGGGGTCATCTCTGG ATTCAAGCTGGAGTGCAGGAAGACCACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAACACAGGTGAATGTTGTGGGAGATG TTTGCCTACGGCTTGCACCATTCAGCTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGACGCTCCAGGATGGCTGTGATACTCA CTTCTGCAAGGTCAATGAGAGAGGAGAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTTGATGAACACAAGTGTCTGGCTGA GGGAGGTAAAATTATGAAAATTCCAGGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGACATCACTGCCAGGCTGCAGTATGT CAAGGTGGGAAGCTGTAAGTCTGAAGTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGCAAAGCCATGTACTCCATTGACAT CAACGATGTGCAGGACCAGTGCTCCTGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCTGCACTGCACCAATGGCTCTGTTGT GTACCATGAGGTTCTCAATGCCATGGAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTGCTGCAGCTGCATGGGTGCCTGCTG CTGCCTGCCTTGGCCTGATGGCCAGGCCAGAGTGCTGCCAGTCCTCTGCATGTTCTGCTCTTGTGCCCTTCTGAGCCCACAATAAAGGCT >In-frame_ENST00000589028_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(amino acids)=1257AA_start in transcript=157_stop in transcript=3930 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDM EDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRN VSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENN TGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECND -------------------------------------------------------------- >In-frame_ENST00000355446_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(transcript)=4047nt_BP=2751nt GATTGGACAGCTGGGGACCTTCTTCTGATTAACCTTAAACCAACTTGTAGCCATAGAGACACCTCACAAGGTTCCCATTTTTGTTGTTGT TGTTGTTGATTTTCTGCTCACACCTTTCCTGACCTTGCAACCATGTATGGAAGTGCCCGCTCTGTTGGGAAGGTGGAGCCGAGCAGCCAG AGCCCTGGGCGTTCACCCAGGCTTCCACGTTCCCCTCGCTTGGGTCACCGTCGAACCAACAGTACGGGAGGGAGTTCGGGAAGCAGTGTT GGAGGTGGCAGTGGGAAAACCCTTTCAATGGAAAATATACAATCTTTAAATGCTGCCTATGCCACCTCTGGCCCTATGTATCTAAGTGAC CATGAAAATGTGGGTTCAGAAACACCTAAAAGCACCATGACACTTGGCCGTTCTGGGGGACGTCTGCCTTACGGTGTTCGGATGACTGCT ATGGGTAGTAGCCCCAATATAGCTAGCAGTGGGGTTGCTAGTGACACCATAGCATTTGGAGAGCATCACCTCCCTCCTGTGAGTATGGCA TCCACTGTACCTCACTCCCTTCGTCAGGCGAGAGATAACACAATCATGGATCTGCAGACACAGCTGAAGGAAGTATTAAGAGAAAATGAT CTCTTGCGGAAGGATGTGGAAGTAAAGGAGAGCAAATTGAGTTCTTCAATGAATAGCATCAAGACCTTCTGGAGCCCAGAGCTGAAGAAG GAACGAGCCCTGAGAAAAGATGAAGCTTCCAAAATCACCATTTGGAAGGAACAGTACAGAGTTGTACAGGAGGAAAACCAGCACATGCAG ATGACAATCCAGGCTCTCCAGGATGAATTGCGGATCCAGAGGGACCTGAATCAGCTGTTTCAGCAGGATAGTAGCAGCAGGACTGGCGAA CCTTGTGTAGCAGAGCTGACAGAGGAGAACTTTCAGAGGCTTCATGCTGAGCATGAGCGGCAGGCCAAAGAGCTGTTTCTTCTTCGAAAG ACATTGGAGGAAATGGAGCTGCGTATTGAGACTCAAAAGCAGACCCTAAATGCTCGGGATGAATCCATTAAGAAGCTTCTGGAAATGTTG CAGAGCAAAGGACTTTCTGCCAAGGCTACCGAGGAAGACCATGAGAGAACAAGACGACTGGCAGAGGCAGAGATGCACGTTCATCACCTA GAAAGCCTTTTGGAGCAGAAGGAAAAAGAGAACAGTATGTTGAGAGAGGAGATGCATCGAAGGTTTGAGAATGCTCCTGATTCTGCCAAA ACAAAAGCTCTGCAAACTGTTATTGAGATGAAGGATTCAAAAATTTCCTCTATGGAGCGTGGGCTTCGAGACCTGGAAGAGGAAATTCAG ATGCTGAAATCGAATGGTGCTTTGAGTACTGAGGAAAGGGAAGAAGAAATGAAGCAAATGGAAGTGTATCGGAGCCATTCTAAATTTATG AAAAATAAGGTAGAACAACTGAAGGAGGAACTAAGTTCGAAAGAGGCTCAATGGGAGGAGCTGAAAAAGAAAGCGGCTGGTCTTCAGGCT GAGATTGGCCAGGTGAAACAGGAGCTGTCCAGAAAGGACACAGAACTACTCGCCCTGCAGACAAAGCTAGAAACACTCACAAACCAGTTC TCAGATAGTAAACAGCACATTGAAGTGTTGAAGGAGTCCTTGACTGCTAAGGAGCAGAGGGCTGCCATCCTGCAGACTGAGGTGGATGCT CTCCGATTGCGTTTGGAAGAGAAGGAAACCATGTTGAATAAAAAGACAAAACAAATTCAGGATATGGCTGAAGAGAAGGGGACACAAGCT GGAGAGATACATGACCTCAAGGACATGTTGGATGTGAAGGAGCGGAAGGTTAATGTTCTTCAGAAGAAGATTGAAAATCTTCAAGAGCAG CTTAGAGACAAGGAAAAGCAGATGAGCAGCTTGAAAGAACGGGTCAAATCCTTGCAGGCTGACACCACCAACACTGACACTGCCTTGACA ACTTTGGAGGAGGCCCTTGCAGAGAAAGAGCGGACAATTGAACGCTTAAAGGAGCAGAGGGACAGAGATGAGCGAGAGAAGCAAGAGGAA ATTGATAACTACAAAAAAGATCTTAAAGACTTGAAGGAAAAAGTCAGCCTGTTGCAAGGCGACCTTTCAGAGAAAGAGGCTTCACTTTTG GATCTGAAAGAGCATGCTTCTTCTCTGGCATCCTCAGGACTGAAAAAGGACTCACGGCTTAAGACACTAGAGATTGCTTTGGAGCAGAAG AAGGAGGAGTGTCTGAAAATGGAATCACAATTGAAAAAGGCACATGAGGCAGCATTGGAAGCCAGAGCCAGTCCAGAGATGAGTGACCGA ATACAGCACTTGGAGAGAGAGATCACCAGGTACAAAGATGAATCTAGCAAGGCCCAGGCAGAAGTTGATCGACTCTTAGAAATCTTGAAG GAGGTGGAAAATGAGAAGAATGACAAAGATAAGAAGATAGCTGAGTTGGAAAGGCAAGTGAAAGACCAGAATAAGAAGGTAGCAAATCTG AAGCACAAGGAACAGGTGGAAAAAAAGAAGAGTGCACAAATGTTAGAGGAGGCGCGACGACGGGAGGACAATCTCAACGACAGCTCTCAG CAGCTACAGGACAGTCTCCGTAAGAAGGATGACAGGATTGAAGAGCTGGAAGAAGCACTAAGAGAAAGTGTACAGATAACTGCAGAGCGG GAAATGGTGCTAGCACAAGAGGAATCAGCCAGGACCAATGCTGAAAAACAGGTGTGTGTCCACCGAAGCACCATCTACCCTGTGGGCCAG TTCTGGGAGGAGGGCTGCGATGTGTGCACCTGCACCGACATGGAGGATGCCGTGATGGGCCTCCGCGTGGCCCAGTGCTCCCAGAAGCCC TGTGAGGACAGCTGTCGGTCGGGCTTCACTTACGTTCTGCATGAAGGCGAGTGCTGTGGAAGGTGCCTGCCATCTGCCTGTGAGGTGGTG ACTGGCTCACCGCGGGGGGACTCCCAGTCTTCCTGGAAGAGTGTCGGCTCCCAGTGGGCCTCCCCGGAGAACCCCTGCCTCATCAATGAG TGTGTCCGAGTGAAGGAGGAGGTCTTTATACAACAAAGGAACGTCTCCTGCCCCCAGCTGGAGGTCCCTGTCTGCCCCTCGGGCTTTCAG CTGAGCTGTAAGACCTCAGCGTGCTGCCCAAGCTGTCGCTGTGAGCGCATGGAGGCCTGCATGCTCAATGGCACTGTCATTGGGCCCGGG AAGACTGTGATGATCGATGTGTGCACGACCTGCCGCTGCATGGTGCAGGTGGGGGTCATCTCTGGATTCAAGCTGGAGTGCAGGAAGACC ACCTGCAACCCCTGCCCCCTGGGTTACAAGGAAGAAAATAACACAGGTGAATGTTGTGGGAGATGTTTGCCTACGGCTTGCACCATTCAG CTAAGAGGAGGACAGATCATGACACTGAAGCGTGATGAGACGCTCCAGGATGGCTGTGATACTCACTTCTGCAAGGTCAATGAGAGAGGA GAGTACTTCTGGGAGAAGAGGGTCACAGGCTGCCCACCCTTTGATGAACACAAGTGTCTGGCTGAGGGAGGTAAAATTATGAAAATTCCA GGCACCTGCTGTGACACATGTGAGGAGCCTGAGTGCAACGACATCACTGCCAGGCTGCAGTATGTCAAGGTGGGAAGCTGTAAGTCTGAA GTAGAGGTGGATATCCACTACTGCCAGGGCAAATGTGCCAGCAAAGCCATGTACTCCATTGACATCAACGATGTGCAGGACCAGTGCTCC TGCTGCTCTCCGACACGGACGGAGCCCATGCAGGTGGCCCTGCACTGCACCAATGGCTCTGTTGTGTACCATGAGGTTCTCAATGCCATG GAGTGCAAATGCTCCCCCAGGAAGTGCAGCAAGTGAGGCTGCTGCAGCTGCATGGGTGCCTGCTGCTGCCTGCCTTGGCCTGATGGCCAG >In-frame_ENST00000355446_ENST00000261405_TCGA-05-4415-01A_ERC1_chr12_1372331_+_VWF_chr12_6085426_length(amino acids)=1257AA_start in transcript=132_stop in transcript=3905 MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVCVHRSTIYPVGQFWEEGCDVCTCTDM EDAVMGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKEEVFIQQRN VSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENN TGECCGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIPGTCCDTCEEPECND -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ERC1-VWF |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ERC1-VWF |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ERC1-VWF |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ERC1 | C0238463 | Papillary thyroid carcinoma | 1 | ORPHANET |
Hgene | ERC1 | C4749581 | Distal monosomy 12p | 1 | ORPHANET |
Tgene | VWF | C1264040 | von Willebrand Disease, Type 2 | 30 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | VWF | C1264041 | von Willebrand Disease, Type 3 | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | VWF | C0020538 | Hypertensive disease | 3 | CTD_human |
Tgene | VWF | C1264039 | von Willebrand Disease, Type 1 | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | VWF | C0040053 | Thrombosis | 2 | CTD_human |
Tgene | VWF | C0087086 | Thrombus | 2 | CTD_human |
Tgene | VWF | C0001956 | Alcohol Use Disorder | 1 | PSYGENET |
Tgene | VWF | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | VWF | C0004238 | Atrial Fibrillation | 1 | CTD_human |
Tgene | VWF | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
Tgene | VWF | C0018801 | Heart failure | 1 | CTD_human |
Tgene | VWF | C0018802 | Congestive heart failure | 1 | CTD_human |
Tgene | VWF | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Tgene | VWF | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
Tgene | VWF | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | VWF | C0079102 | Cerebral Thrombosis | 1 | CTD_human |
Tgene | VWF | C0235480 | Paroxysmal atrial fibrillation | 1 | CTD_human |
Tgene | VWF | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
Tgene | VWF | C0752143 | Intracranial Thrombosis | 1 | CTD_human |
Tgene | VWF | C0752144 | Brain Thrombosis | 1 | CTD_human |
Tgene | VWF | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Tgene | VWF | C0936261 | Brain Thrombus | 1 | CTD_human |
Tgene | VWF | C0936263 | Cerebral Thrombus | 1 | CTD_human |
Tgene | VWF | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Tgene | VWF | C1959583 | Myocardial Failure | 1 | CTD_human |
Tgene | VWF | C1961112 | Heart Decompensation | 1 | CTD_human |
Tgene | VWF | C2585653 | Persistent atrial fibrillation | 1 | CTD_human |
Tgene | VWF | C3468561 | familial atrial fibrillation | 1 | CTD_human |
Tgene | VWF | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Tgene | VWF | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | VWF | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |