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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERG-EWSR1 (FusionGDB2 ID:27304)

Fusion Gene Summary for ERG-EWSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERG-EWSR1
Fusion gene ID: 27304
HgeneTgene
Gene symbol

ERG

EWSR1

Gene ID

2078

2130

Gene nameETS transcription factor ERGEWS RNA binding protein 1
Synonymserg-3|p55EWS|EWS-FLI1|bK984G1.4
Cytomap

21q22.2

22q12.2

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avianRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene
Modification date2020032020200329
UniProtAcc.

Q01844

Ensembl transtripts involved in fusion geneENST00000398907, ENST00000398905, 
ENST00000288319, ENST00000398897, 
ENST00000398911, ENST00000398910, 
ENST00000417133, ENST00000442448, 
ENST00000453032, ENST00000398919, 
ENST00000429727, ENST00000485493, 
ENST00000332050, ENST00000397938, 
ENST00000406548, ENST00000331029, 
ENST00000414183, ENST00000333395, 
ENST00000332035, 
Fusion gene scores* DoF score19 X 16 X 5=152017 X 58 X 10=9860
# samples 3148
** MAII scorelog2(31/1520*10)=-2.29373120305671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(48/9860*10)=-4.36048133565676
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERG [Title/Abstract] AND EWSR1 [Title/Abstract] AND fusion [Title/Abstract]

Ewing sarcoma with ERG gene rearrangements: A molecular study focusing on the prevalence of FUS-ERG and common pitfalls in detecting EWSR1-ERG fusions by FISH (pmid: 26690869)
Most frequent breakpointEWSR1(29683123)-ERG(39764366), # samples:2
ERG(39762959)-EWSR1(29682948), # samples:1
Anticipated loss of major functional domain due to fusion event.EWSR1-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EWSR1-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EWSR1-ERG seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
EWSR1-ERG seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
EWSR1-ERG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check buttonFusion gene breakpoints across ERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EWSR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AS82338ERGchr21

39762959

-EWSR1chr22

29682948

+


Top

Fusion Gene ORF analysis for ERG-EWSR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398907ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398907ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398905ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000288319ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398897ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398911ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398910ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000417133ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000442448ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000453032ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000398919ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000429727ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000332050ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000397938ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000406548ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000331029ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000414183ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000333395ERGchr21

39762959

-EWSR1chr22

29682948

+
intron-3CDSENST00000485493ENST00000332035ERGchr21

39762959

-EWSR1chr22

29682948

+
Frame-shiftENST00000288319ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000288319ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000288319ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000288319ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000288319ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000288319ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000288319ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398905ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398905ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398905ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398905ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398905ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398905ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398905ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398907ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398907ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398907ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398907ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398907ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398907ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398907ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398911ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398911ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398911ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398911ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398911ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398911ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398911ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398919ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398919ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398919ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398919ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398919ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398919ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000398919ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000453032ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000453032ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000453032ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000453032ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000453032ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000453032ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
Frame-shiftENST00000453032ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398897ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398897ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398897ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398897ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398897ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398897ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398897ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398910ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398910ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398910ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398910ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398910ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398910ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000398910ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000417133ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000417133ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000417133ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000417133ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000417133ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000417133ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000417133ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000442448ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000442448ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000442448ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000442448ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000442448ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000442448ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
In-frameENST00000442448ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000429727ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000429727ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000429727ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000429727ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000429727ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000429727ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000429727ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000485493ENST00000331029ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000485493ENST00000332035ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000485493ENST00000332050ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000485493ENST00000333395ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000485493ENST00000397938ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000485493ENST00000406548ERGchr21

39762917

-EWSR1chr22

29682912

+
intron-3CDSENST00000485493ENST00000414183ERGchr21

39762917

-EWSR1chr22

29682912

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ERG-EWSR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ERG-EWSR1


check button Go to

FGviewer for the breakpoints of chr21:39762917-chr22:29682912

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EWSR1

Q01844

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ERG-EWSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ERG-EWSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERG-EWSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERG-EWSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms7CTD_human
HgeneERGC0376358Malignant neoplasm of prostate7CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneEWSR1C0553580Ewings sarcoma3CTD_human;ORPHANET
TgeneEWSR1C0002736Amyotrophic Lateral Sclerosis1GENOMICS_ENGLAND
TgeneEWSR1C0033578Prostatic Neoplasms1CTD_human
TgeneEWSR1C0206651Clear Cell Sarcoma of Soft Tissue1ORPHANET
TgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human
TgeneEWSR1C0279980Extra-osseous Ewing's sarcoma1ORPHANET
TgeneEWSR1C0334584Spongioblastoma1CTD_human
TgeneEWSR1C0334596Medulloepithelioma1CTD_human
TgeneEWSR1C0376358Malignant neoplasm of prostate1CTD_human
TgeneEWSR1C0700367Ependymoblastoma1CTD_human
TgeneEWSR1C0751675Cerebral Primitive Neuroectodermal Tumor1CTD_human
TgeneEWSR1C1275278Extraskeletal Myxoid Chondrosarcoma1ORPHANET