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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ERLEC1-ACYP2 (FusionGDB2 ID:27377)

Fusion Gene Summary for ERLEC1-ACYP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ERLEC1-ACYP2
Fusion gene ID: 27377
HgeneTgene
Gene symbol

ERLEC1

ACYP2

Gene ID

27248

98

Gene nameendoplasmic reticulum lectin 1acylphosphatase 2
SynonymsC2orf30|CIM|CL24936|CL25084|HEL117|XTP3-B|XTP3TPBACYM|ACYP
Cytomap

2p16.2

2p16.2

Type of geneprotein-codingprotein-coding
Descriptionendoplasmic reticulum lectin 1ER lectinXTP3-transactivated gene B proteinXTP3-transactivated protein Bcancer invasion and metastasis-relatedepididymis luminal protein 117erlectin 1acylphosphatase-2acylphosphatase 2, muscle typeacylphosphatase, muscle type isozymeacylphosphate phosphohydrolase 2testicular tissue protein Li 11
Modification date2020031320200313
UniProtAcc

Q96DZ1

P14621

Ensembl transtripts involved in fusion geneENST00000494373, ENST00000405123, 
ENST00000185150, ENST00000378239, 
ENST00000607452, ENST00000303536, 
ENST00000394666, ENST00000606865, 
ENST00000458030, ENST00000422521, 
ENST00000606082, ENST00000406041, 
Fusion gene scores* DoF score5 X 5 X 6=1508 X 7 X 6=336
# samples 610
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERLEC1 [Title/Abstract] AND ACYP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointERLEC1(54040210)-ACYP2(54278095), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ERLEC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ACYP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-L9-A8F4-01AERLEC1chr2

54040210

+ACYP2chr2

54278095

+
ChimerDB4PRADTCGA-EJ-5515-01AERLEC1chr2

54028979

+ACYP2chr2

54531825

+
ChimerDB4LUADTCGA-L9-A8F4ERLEC1chr2

54040210

+ACYP2chr2

54278095

+


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Fusion Gene ORF analysis for ERLEC1-ACYP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000494373ENST00000607452ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
intron-intronENST00000494373ENST00000303536ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
intron-intronENST00000494373ENST00000394666ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
intron-intronENST00000494373ENST00000606865ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
intron-3UTRENST00000494373ENST00000458030ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
intron-3UTRENST00000494373ENST00000422521ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
intron-intronENST00000494373ENST00000606082ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
intron-intronENST00000494373ENST00000406041ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
In-frameENST00000405123ENST00000607452ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000405123ENST00000303536ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000405123ENST00000394666ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000405123ENST00000606865ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-3UTRENST00000405123ENST00000458030ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-3UTRENST00000405123ENST00000422521ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000405123ENST00000606082ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000405123ENST00000406041ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
In-frameENST00000185150ENST00000607452ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000185150ENST00000303536ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000185150ENST00000394666ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000185150ENST00000606865ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-3UTRENST00000185150ENST00000458030ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-3UTRENST00000185150ENST00000422521ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000185150ENST00000606082ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000185150ENST00000406041ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
In-frameENST00000378239ENST00000607452ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000378239ENST00000303536ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000378239ENST00000394666ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000378239ENST00000606865ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-3UTRENST00000378239ENST00000458030ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-3UTRENST00000378239ENST00000422521ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000378239ENST00000606082ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
5CDS-intronENST00000378239ENST00000406041ERLEC1chr2

54040210

+ACYP2chr2

54278095

+
intron-3CDSENST00000494373ENST00000607452ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
intron-3UTRENST00000494373ENST00000303536ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
intron-3UTRENST00000494373ENST00000394666ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
intron-3UTRENST00000494373ENST00000606865ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
intron-intronENST00000494373ENST00000458030ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
intron-intronENST00000494373ENST00000422521ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
intron-intronENST00000494373ENST00000606082ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
intron-intronENST00000494373ENST00000406041ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
In-frameENST00000405123ENST00000607452ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-3UTRENST00000405123ENST00000303536ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-3UTRENST00000405123ENST00000394666ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-3UTRENST00000405123ENST00000606865ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000405123ENST00000458030ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000405123ENST00000422521ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000405123ENST00000606082ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000405123ENST00000406041ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
In-frameENST00000185150ENST00000607452ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-3UTRENST00000185150ENST00000303536ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-3UTRENST00000185150ENST00000394666ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-3UTRENST00000185150ENST00000606865ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000185150ENST00000458030ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000185150ENST00000422521ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000185150ENST00000606082ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000185150ENST00000406041ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
In-frameENST00000378239ENST00000607452ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-3UTRENST00000378239ENST00000303536ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-3UTRENST00000378239ENST00000394666ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-3UTRENST00000378239ENST00000606865ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000378239ENST00000458030ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000378239ENST00000422521ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000378239ENST00000606082ERLEC1chr2

54028979

+ACYP2chr2

54531825

+
5CDS-intronENST00000378239ENST00000406041ERLEC1chr2

54028979

+ACYP2chr2

54531825

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405123ERLEC1chr254040210+ENST00000607452ACYP2chr254278095+187113571311813560
ENST00000185150ERLEC1chr254040210+ENST00000607452ACYP2chr254278095+187113571311813560
ENST00000378239ERLEC1chr254040210+ENST00000607452ACYP2chr254278095+170911951311651506
ENST00000405123ERLEC1chr254028979+ENST00000607452ACYP2chr254531825+118210101311042303
ENST00000185150ERLEC1chr254028979+ENST00000607452ACYP2chr254531825+118210101311042303
ENST00000378239ERLEC1chr254028979+ENST00000607452ACYP2chr254531825+118210101311042303

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405123ENST00000607452ERLEC1chr254040210+ACYP2chr254278095+0.0017926260.99820733
ENST00000185150ENST00000607452ERLEC1chr254040210+ACYP2chr254278095+0.0017926260.99820733
ENST00000378239ENST00000607452ERLEC1chr254040210+ACYP2chr254278095+0.0014831720.99851686
ENST00000405123ENST00000607452ERLEC1chr254028979+ACYP2chr254531825+0.0026465860.99735343
ENST00000185150ENST00000607452ERLEC1chr254028979+ACYP2chr254531825+0.0026465860.99735343
ENST00000378239ENST00000607452ERLEC1chr254028979+ACYP2chr254531825+0.0026465860.99735343

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Fusion Genomic Features for ERLEC1-ACYP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ERLEC1chr254028979+ACYP2chr254531824+7.43E-070.9999993
ERLEC1chr254040210+ACYP2chr254278094+9.24E-080.9999999
ERLEC1chr254040210+ACYP2chr254278094+9.24E-080.9999999
ERLEC1chr254028979+ACYP2chr254531824+7.43E-070.9999993
ERLEC1chr254040210+ACYP2chr254278094+9.24E-080.9999999
ERLEC1chr254040210+ACYP2chr254278094+9.24E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ERLEC1-ACYP2


check button Go to

FGviewer for the breakpoints of chr2:54040210-chr2:54278095

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERLEC1

Q96DZ1

ACYP2

P14621

FUNCTION: Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. {ECO:0000269|PubMed:16531414, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18502753}.FUNCTION: Its physiological role is not yet clear.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERLEC1chr2:54028979chr2:54531825ENST00000185150+814111_246293.0484.0DomainMRH 1
HgeneERLEC1chr2:54028979chr2:54531825ENST00000378239+813111_246293.0430.0DomainMRH 1
HgeneERLEC1chr2:54028979chr2:54531825ENST00000405123+813111_246293.0458.0DomainMRH 1
HgeneERLEC1chr2:54040210chr2:54278095ENST00000185150+1114111_246408.6666666666667484.0DomainMRH 1
HgeneERLEC1chr2:54040210chr2:54278095ENST00000378239+1013111_246354.6666666666667430.0DomainMRH 1
HgeneERLEC1chr2:54040210chr2:54278095ENST00000405123+1113111_246408.6666666666667458.0DomainMRH 1
TgeneACYP2chr2:54040210chr2:54278095ENST00000394666049_990100.0DomainAcylphosphatase-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERLEC1chr2:54028979chr2:54531825ENST00000185150+814342_469293.0484.0DomainMRH 2
HgeneERLEC1chr2:54028979chr2:54531825ENST00000378239+813342_469293.0430.0DomainMRH 2
HgeneERLEC1chr2:54028979chr2:54531825ENST00000405123+813342_469293.0458.0DomainMRH 2
HgeneERLEC1chr2:54040210chr2:54278095ENST00000185150+1114342_469408.6666666666667484.0DomainMRH 2
HgeneERLEC1chr2:54040210chr2:54278095ENST00000378239+1013342_469354.6666666666667430.0DomainMRH 2
HgeneERLEC1chr2:54040210chr2:54278095ENST00000405123+1113342_469408.6666666666667458.0DomainMRH 2
TgeneACYP2chr2:54028979chr2:54531825ENST00000394666249_9961.666666666666664100.0DomainAcylphosphatase-like


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Fusion Gene Sequence for ERLEC1-ACYP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000405123_ENST00000607452_TCGA-L9-A8F4-01A_ERLEC1_chr2_54040210_+_ACYP2_chr2_54278095_length(transcript)=1871nt_BP=1357nt
GGCGGCGGTTGGGCCGGTGATACCCGGGCGCTTTATAGTCCCGCCGCCTCCTCCTCCACCTCCTCCTCCTCCTCCTCTCCTCCTGGAGCA
GAGGAGGTTGTGGCGGTGGCTGGAGAAAGCGGCGGCGGAGGATGGAGGAAGGAGGCGGCGGCGTACGGAGTCTGGTCCCGGGCGGGCCGG
TGTTACTGGTCCTCTGCGGCCTCCTGGAGGCGTCCGGCGGCGGCCGAGCCCTTCCTCAACTCAGCGATGACATCCCTTTCCGAGTCAACT
GGCCCGGCACCGAGTTCTCTCTGCCCACAACTGGAGTTTTATATAAAGAAGATAATTATGTCATCATGACAACTGCACATAAAGAAAAAT
ATAAATGCATACTTCCCCTTGTGACAAGTGGGGATGAGGAAGAAGAAAAGGATTATAAAGGCCCTAATCCAAGAGAGCTTTTGGAGCCAC
TATTTAAACAAAGCAGTTGTTCCTACAGAATTGAGTCTTATTGGACTTACGAAGTATGTCATGGAAAACACATTCGGCAGTACCATGAAG
AGAAAGAAACTGGTCAGAAAATAAATATTCACGAGTACTACCTTGGGAATATGTTGGCCAAGAACCTTCTATTTGAAAAAGAACGAGAAG
CAGAAGAAAAGGAAAAATCAAATGAGATTCCCACTAAAAATATCGAAGGTCAGATGACACCATACTATCCTGTGGGAATGGGAAATGGTA
CACCTTGTAGTTTGAAACAGAACCGGCCCAGATCAAGTACTGTGATGTACATATGTCATCCTGAATCTAAGCATGAAATTCTTTCAGTAG
CTGAAGTTACAACTTGTGAATATGAAGTTGTCATTTTGACACCACTCTTGTGCAGTCATCCTAAATATAGGTTCAGAGCATCTCCTGTGA
ATGACATATTTTGTCAATCACTGCCAGGATCTCCATTTAAGCCCCTCACCCTGAGGCAGCTGGAGCAGCAGGAAGAAATACTAAGGGTGC
CTTTTAGGAGAAATAAAGAGGAAGATTTGCAATCAACTAAAGAAGAGAGATTTCCAGCGATCCACAAGTCGATTGCTATTGGCTCTCAGC
CAGTGCTCACTGTTGGGACAACCCACATATCCAAATTGACAGATGACCAACTCATAAAAGAGTTTCTTAGTGGTTCTTACTGCTTTCGTG
GGGGTGTCGGTTGGTGGAAATATGAATTCTGCTATGGCAAACATGTACATCAATACCATGAGGACAAGGATAGTGGGAAAACCTCTGTGG
TTGTCGGGACATGGAACCAAGAAGAGCATATTGAATGGGCTAAGAAGAATACTGCTAGAGCTTATCATCTTCAAGACGATGGTACCCAGA
CAGTCAGATACAAGGTCTCGCTGTTCTACCTAGGCTGTTCTAGAACTCCTAATGTCAAGCTATCCTCCTGCCTCGGCCTCCCATGCTGTT
GGGATTACAGCTATAAATTCATACAATTATCAGAGTTTGGTTTTGGTCAAGTCATAATTGTGAGTGAAGAACCATGGAAGGAGAACATTT
CTTGCTCATCAACTACTTTCATAAAATCAACAATTTGCTTAAGTGTTTGCTTCAGAATGTATACAGAAGATGAAGCTAGGAAAATAGGAG
TGGTTGGCTGGGTGAAGAATACCAGCAAAGGCACCGTGACAGGCCAAGTGCAGGGGCCAGAAGACAAAGTCAATTCCATGAAGTCCTGGC
TGAGCAAGGTTGGAAGCCCTAGTTCTCGCATTGACCGCACAAACTTTTCTAATGAAAAAACCATCTCTAAGCTTGAATACTCTAATTTTA

>In-frame_ENST00000405123_ENST00000607452_TCGA-L9-A8F4-01A_ERLEC1_chr2_54040210_+_ACYP2_chr2_54278095_length(amino acids)=560AA_start in transcript=131_stop in transcript=1813
MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEE
EEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKN
IEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFK
PLTLRQLEQQEEILRVPFRRNKEEDLQSTKEERFPAIHKSIAIGSQPVLTVGTTHISKLTDDQLIKEFLSGSYCFRGGVGWWKYEFCYGK
HVHQYHEDKDSGKTSVVVGTWNQEEHIEWAKKNTARAYHLQDDGTQTVRYKVSLFYLGCSRTPNVKLSSCLGLPCCWDYSYKFIQLSEFG
FGQVIIVSEEPWKENISCSSTTFIKSTICLSVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVNSMKSWLSKVGSPSSRIDRT

--------------------------------------------------------------
>In-frame_ENST00000185150_ENST00000607452_TCGA-L9-A8F4-01A_ERLEC1_chr2_54040210_+_ACYP2_chr2_54278095_length(transcript)=1871nt_BP=1357nt
GGCGGCGGTTGGGCCGGTGATACCCGGGCGCTTTATAGTCCCGCCGCCTCCTCCTCCACCTCCTCCTCCTCCTCCTCTCCTCCTGGAGCA
GAGGAGGTTGTGGCGGTGGCTGGAGAAAGCGGCGGCGGAGGATGGAGGAAGGAGGCGGCGGCGTACGGAGTCTGGTCCCGGGCGGGCCGG
TGTTACTGGTCCTCTGCGGCCTCCTGGAGGCGTCCGGCGGCGGCCGAGCCCTTCCTCAACTCAGCGATGACATCCCTTTCCGAGTCAACT
GGCCCGGCACCGAGTTCTCTCTGCCCACAACTGGAGTTTTATATAAAGAAGATAATTATGTCATCATGACAACTGCACATAAAGAAAAAT
ATAAATGCATACTTCCCCTTGTGACAAGTGGGGATGAGGAAGAAGAAAAGGATTATAAAGGCCCTAATCCAAGAGAGCTTTTGGAGCCAC
TATTTAAACAAAGCAGTTGTTCCTACAGAATTGAGTCTTATTGGACTTACGAAGTATGTCATGGAAAACACATTCGGCAGTACCATGAAG
AGAAAGAAACTGGTCAGAAAATAAATATTCACGAGTACTACCTTGGGAATATGTTGGCCAAGAACCTTCTATTTGAAAAAGAACGAGAAG
CAGAAGAAAAGGAAAAATCAAATGAGATTCCCACTAAAAATATCGAAGGTCAGATGACACCATACTATCCTGTGGGAATGGGAAATGGTA
CACCTTGTAGTTTGAAACAGAACCGGCCCAGATCAAGTACTGTGATGTACATATGTCATCCTGAATCTAAGCATGAAATTCTTTCAGTAG
CTGAAGTTACAACTTGTGAATATGAAGTTGTCATTTTGACACCACTCTTGTGCAGTCATCCTAAATATAGGTTCAGAGCATCTCCTGTGA
ATGACATATTTTGTCAATCACTGCCAGGATCTCCATTTAAGCCCCTCACCCTGAGGCAGCTGGAGCAGCAGGAAGAAATACTAAGGGTGC
CTTTTAGGAGAAATAAAGAGGAAGATTTGCAATCAACTAAAGAAGAGAGATTTCCAGCGATCCACAAGTCGATTGCTATTGGCTCTCAGC
CAGTGCTCACTGTTGGGACAACCCACATATCCAAATTGACAGATGACCAACTCATAAAAGAGTTTCTTAGTGGTTCTTACTGCTTTCGTG
GGGGTGTCGGTTGGTGGAAATATGAATTCTGCTATGGCAAACATGTACATCAATACCATGAGGACAAGGATAGTGGGAAAACCTCTGTGG
TTGTCGGGACATGGAACCAAGAAGAGCATATTGAATGGGCTAAGAAGAATACTGCTAGAGCTTATCATCTTCAAGACGATGGTACCCAGA
CAGTCAGATACAAGGTCTCGCTGTTCTACCTAGGCTGTTCTAGAACTCCTAATGTCAAGCTATCCTCCTGCCTCGGCCTCCCATGCTGTT
GGGATTACAGCTATAAATTCATACAATTATCAGAGTTTGGTTTTGGTCAAGTCATAATTGTGAGTGAAGAACCATGGAAGGAGAACATTT
CTTGCTCATCAACTACTTTCATAAAATCAACAATTTGCTTAAGTGTTTGCTTCAGAATGTATACAGAAGATGAAGCTAGGAAAATAGGAG
TGGTTGGCTGGGTGAAGAATACCAGCAAAGGCACCGTGACAGGCCAAGTGCAGGGGCCAGAAGACAAAGTCAATTCCATGAAGTCCTGGC
TGAGCAAGGTTGGAAGCCCTAGTTCTCGCATTGACCGCACAAACTTTTCTAATGAAAAAACCATCTCTAAGCTTGAATACTCTAATTTTA

>In-frame_ENST00000185150_ENST00000607452_TCGA-L9-A8F4-01A_ERLEC1_chr2_54040210_+_ACYP2_chr2_54278095_length(amino acids)=560AA_start in transcript=131_stop in transcript=1813
MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEE
EEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKN
IEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFK
PLTLRQLEQQEEILRVPFRRNKEEDLQSTKEERFPAIHKSIAIGSQPVLTVGTTHISKLTDDQLIKEFLSGSYCFRGGVGWWKYEFCYGK
HVHQYHEDKDSGKTSVVVGTWNQEEHIEWAKKNTARAYHLQDDGTQTVRYKVSLFYLGCSRTPNVKLSSCLGLPCCWDYSYKFIQLSEFG
FGQVIIVSEEPWKENISCSSTTFIKSTICLSVCFRMYTEDEARKIGVVGWVKNTSKGTVTGQVQGPEDKVNSMKSWLSKVGSPSSRIDRT

--------------------------------------------------------------
>In-frame_ENST00000378239_ENST00000607452_TCGA-L9-A8F4-01A_ERLEC1_chr2_54040210_+_ACYP2_chr2_54278095_length(transcript)=1709nt_BP=1195nt
GGCGGCGGTTGGGCCGGTGATACCCGGGCGCTTTATAGTCCCGCCGCCTCCTCCTCCACCTCCTCCTCCTCCTCCTCTCCTCCTGGAGCA
GAGGAGGTTGTGGCGGTGGCTGGAGAAAGCGGCGGCGGAGGATGGAGGAAGGAGGCGGCGGCGTACGGAGTCTGGTCCCGGGCGGGCCGG
TGTTACTGGTCCTCTGCGGCCTCCTGGAGGCGTCCGGCGGCGGCCGAGCCCTTCCTCAACTCAGCGATGACATCCCTTTCCGAGTCAACT
GGCCCGGCACCGAGTTCTCTCTGCCCACAACTGGAGTTTTATATAAAGAAGATAATTATGTCATCATGACAACTGCACATAAAGAAAAAT
ATAAATGCATACTTCCCCTTGTGACAAGTGGGGATGAGGAAGAAGAAAAGGATTATAAAGGCCCTAATCCAAGAGAGCTTTTGGAGCCAC
TATTTAAACAAAGCAGTTGTTCCTACAGAATTGAGTCTTATTGGACTTACGAAGTATGTCATGGAAAACACATTCGGCAGTACCATGAAG
AGAAAGAAACTGGTCAGAAAATAAATATTCACGAGTACTACCTTGGGAATATGTTGGCCAAGAACCTTCTATTTGAAAAAGAACGAGAAG
CAGAAGAAAAGGAAAAATCAAATGAGATTCCCACTAAAAATATCGAAGGTCAGATGACACCATACTATCCTGTGGGAATGGGAAATGGTA
CACCTTGTAGTTTGAAACAGAACCGGCCCAGATCAAGTACTGTGATGTACATATGTCATCCTGAATCTAAGCATGAAATTCTTTCAGTAG
CTGAAGTTACAACTTGTGAATATGAAGTTGTCATTTTGACACCACTCTTGTGCAGTCATCCTAAATATAGGTTCAGAGCATCTCCTGTGA
ATGACATATTTTGTCAATCACTGCCAGGATCTCCATTTAAGCCCCTCACCCTGAGGCAGCTGGAGCAGCAGGAAGAAATACTAAGGGTGC
CTTTTAGGAGAAATAAAGAGGGTGTCGGTTGGTGGAAATATGAATTCTGCTATGGCAAACATGTACATCAATACCATGAGGACAAGGATA
GTGGGAAAACCTCTGTGGTTGTCGGGACATGGAACCAAGAAGAGCATATTGAATGGGCTAAGAAGAATACTGCTAGAGCTTATCATCTTC
AAGACGATGGTACCCAGACAGTCAGATACAAGGTCTCGCTGTTCTACCTAGGCTGTTCTAGAACTCCTAATGTCAAGCTATCCTCCTGCC
TCGGCCTCCCATGCTGTTGGGATTACAGCTATAAATTCATACAATTATCAGAGTTTGGTTTTGGTCAAGTCATAATTGTGAGTGAAGAAC
CATGGAAGGAGAACATTTCTTGCTCATCAACTACTTTCATAAAATCAACAATTTGCTTAAGTGTTTGCTTCAGAATGTATACAGAAGATG
AAGCTAGGAAAATAGGAGTGGTTGGCTGGGTGAAGAATACCAGCAAAGGCACCGTGACAGGCCAAGTGCAGGGGCCAGAAGACAAAGTCA
ATTCCATGAAGTCCTGGCTGAGCAAGGTTGGAAGCCCTAGTTCTCGCATTGACCGCACAAACTTTTCTAATGAAAAAACCATCTCTAAGC

>In-frame_ENST00000378239_ENST00000607452_TCGA-L9-A8F4-01A_ERLEC1_chr2_54040210_+_ACYP2_chr2_54278095_length(amino acids)=506AA_start in transcript=131_stop in transcript=1651
MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEE
EEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKN
IEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFK
PLTLRQLEQQEEILRVPFRRNKEGVGWWKYEFCYGKHVHQYHEDKDSGKTSVVVGTWNQEEHIEWAKKNTARAYHLQDDGTQTVRYKVSL
FYLGCSRTPNVKLSSCLGLPCCWDYSYKFIQLSEFGFGQVIIVSEEPWKENISCSSTTFIKSTICLSVCFRMYTEDEARKIGVVGWVKNT

--------------------------------------------------------------
>In-frame_ENST00000405123_ENST00000607452_TCGA-EJ-5515-01A_ERLEC1_chr2_54028979_+_ACYP2_chr2_54531825_length(transcript)=1182nt_BP=1010nt
GGCGGCGGTTGGGCCGGTGATACCCGGGCGCTTTATAGTCCCGCCGCCTCCTCCTCCACCTCCTCCTCCTCCTCCTCTCCTCCTGGAGCA
GAGGAGGTTGTGGCGGTGGCTGGAGAAAGCGGCGGCGGAGGATGGAGGAAGGAGGCGGCGGCGTACGGAGTCTGGTCCCGGGCGGGCCGG
TGTTACTGGTCCTCTGCGGCCTCCTGGAGGCGTCCGGCGGCGGCCGAGCCCTTCCTCAACTCAGCGATGACATCCCTTTCCGAGTCAACT
GGCCCGGCACCGAGTTCTCTCTGCCCACAACTGGAGTTTTATATAAAGAAGATAATTATGTCATCATGACAACTGCACATAAAGAAAAAT
ATAAATGCATACTTCCCCTTGTGACAAGTGGGGATGAGGAAGAAGAAAAGGATTATAAAGGCCCTAATCCAAGAGAGCTTTTGGAGCCAC
TATTTAAACAAAGCAGTTGTTCCTACAGAATTGAGTCTTATTGGACTTACGAAGTATGTCATGGAAAACACATTCGGCAGTACCATGAAG
AGAAAGAAACTGGTCAGAAAATAAATATTCACGAGTACTACCTTGGGAATATGTTGGCCAAGAACCTTCTATTTGAAAAAGAACGAGAAG
CAGAAGAAAAGGAAAAATCAAATGAGATTCCCACTAAAAATATCGAAGGTCAGATGACACCATACTATCCTGTGGGAATGGGAAATGGTA
CACCTTGTAGTTTGAAACAGAACCGGCCCAGATCAAGTACTGTGATGTACATATGTCATCCTGAATCTAAGCATGAAATTCTTTCAGTAG
CTGAAGTTACAACTTGTGAATATGAAGTTGTCATTTTGACACCACTCTTGTGCAGTCATCCTAAATATAGGTTCAGAGCATCTCCTGTGA
ATGACATATTTTGTCAATCACTGCCAGGATCTCCATTTAAGCCCCTCACCCTGAGGCAGCTGGAGCAGCAGGAAGAAATACTAAGGGTGC
CTTTTAGGAGAAATAAAGAGGAAGTCCTGGCTGAGCAAGGTTGGAAGCCCTAGTTCTCGCATTGACCGCACAAACTTTTCTAATGAAAAA
ACCATCTCTAAGCTTGAATACTCTAATTTTAGTATTAGATACTAATAGAAGAGAAAAATTGTAACACACTGAACAATAGATACTGTATGT

>In-frame_ENST00000405123_ENST00000607452_TCGA-EJ-5515-01A_ERLEC1_chr2_54028979_+_ACYP2_chr2_54531825_length(amino acids)=303AA_start in transcript=131_stop in transcript=1042
MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEE
EEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKN
IEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFK

--------------------------------------------------------------
>In-frame_ENST00000185150_ENST00000607452_TCGA-EJ-5515-01A_ERLEC1_chr2_54028979_+_ACYP2_chr2_54531825_length(transcript)=1182nt_BP=1010nt
GGCGGCGGTTGGGCCGGTGATACCCGGGCGCTTTATAGTCCCGCCGCCTCCTCCTCCACCTCCTCCTCCTCCTCCTCTCCTCCTGGAGCA
GAGGAGGTTGTGGCGGTGGCTGGAGAAAGCGGCGGCGGAGGATGGAGGAAGGAGGCGGCGGCGTACGGAGTCTGGTCCCGGGCGGGCCGG
TGTTACTGGTCCTCTGCGGCCTCCTGGAGGCGTCCGGCGGCGGCCGAGCCCTTCCTCAACTCAGCGATGACATCCCTTTCCGAGTCAACT
GGCCCGGCACCGAGTTCTCTCTGCCCACAACTGGAGTTTTATATAAAGAAGATAATTATGTCATCATGACAACTGCACATAAAGAAAAAT
ATAAATGCATACTTCCCCTTGTGACAAGTGGGGATGAGGAAGAAGAAAAGGATTATAAAGGCCCTAATCCAAGAGAGCTTTTGGAGCCAC
TATTTAAACAAAGCAGTTGTTCCTACAGAATTGAGTCTTATTGGACTTACGAAGTATGTCATGGAAAACACATTCGGCAGTACCATGAAG
AGAAAGAAACTGGTCAGAAAATAAATATTCACGAGTACTACCTTGGGAATATGTTGGCCAAGAACCTTCTATTTGAAAAAGAACGAGAAG
CAGAAGAAAAGGAAAAATCAAATGAGATTCCCACTAAAAATATCGAAGGTCAGATGACACCATACTATCCTGTGGGAATGGGAAATGGTA
CACCTTGTAGTTTGAAACAGAACCGGCCCAGATCAAGTACTGTGATGTACATATGTCATCCTGAATCTAAGCATGAAATTCTTTCAGTAG
CTGAAGTTACAACTTGTGAATATGAAGTTGTCATTTTGACACCACTCTTGTGCAGTCATCCTAAATATAGGTTCAGAGCATCTCCTGTGA
ATGACATATTTTGTCAATCACTGCCAGGATCTCCATTTAAGCCCCTCACCCTGAGGCAGCTGGAGCAGCAGGAAGAAATACTAAGGGTGC
CTTTTAGGAGAAATAAAGAGGAAGTCCTGGCTGAGCAAGGTTGGAAGCCCTAGTTCTCGCATTGACCGCACAAACTTTTCTAATGAAAAA
ACCATCTCTAAGCTTGAATACTCTAATTTTAGTATTAGATACTAATAGAAGAGAAAAATTGTAACACACTGAACAATAGATACTGTATGT

>In-frame_ENST00000185150_ENST00000607452_TCGA-EJ-5515-01A_ERLEC1_chr2_54028979_+_ACYP2_chr2_54531825_length(amino acids)=303AA_start in transcript=131_stop in transcript=1042
MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEE
EEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKN
IEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFK

--------------------------------------------------------------
>In-frame_ENST00000378239_ENST00000607452_TCGA-EJ-5515-01A_ERLEC1_chr2_54028979_+_ACYP2_chr2_54531825_length(transcript)=1182nt_BP=1010nt
GGCGGCGGTTGGGCCGGTGATACCCGGGCGCTTTATAGTCCCGCCGCCTCCTCCTCCACCTCCTCCTCCTCCTCCTCTCCTCCTGGAGCA
GAGGAGGTTGTGGCGGTGGCTGGAGAAAGCGGCGGCGGAGGATGGAGGAAGGAGGCGGCGGCGTACGGAGTCTGGTCCCGGGCGGGCCGG
TGTTACTGGTCCTCTGCGGCCTCCTGGAGGCGTCCGGCGGCGGCCGAGCCCTTCCTCAACTCAGCGATGACATCCCTTTCCGAGTCAACT
GGCCCGGCACCGAGTTCTCTCTGCCCACAACTGGAGTTTTATATAAAGAAGATAATTATGTCATCATGACAACTGCACATAAAGAAAAAT
ATAAATGCATACTTCCCCTTGTGACAAGTGGGGATGAGGAAGAAGAAAAGGATTATAAAGGCCCTAATCCAAGAGAGCTTTTGGAGCCAC
TATTTAAACAAAGCAGTTGTTCCTACAGAATTGAGTCTTATTGGACTTACGAAGTATGTCATGGAAAACACATTCGGCAGTACCATGAAG
AGAAAGAAACTGGTCAGAAAATAAATATTCACGAGTACTACCTTGGGAATATGTTGGCCAAGAACCTTCTATTTGAAAAAGAACGAGAAG
CAGAAGAAAAGGAAAAATCAAATGAGATTCCCACTAAAAATATCGAAGGTCAGATGACACCATACTATCCTGTGGGAATGGGAAATGGTA
CACCTTGTAGTTTGAAACAGAACCGGCCCAGATCAAGTACTGTGATGTACATATGTCATCCTGAATCTAAGCATGAAATTCTTTCAGTAG
CTGAAGTTACAACTTGTGAATATGAAGTTGTCATTTTGACACCACTCTTGTGCAGTCATCCTAAATATAGGTTCAGAGCATCTCCTGTGA
ATGACATATTTTGTCAATCACTGCCAGGATCTCCATTTAAGCCCCTCACCCTGAGGCAGCTGGAGCAGCAGGAAGAAATACTAAGGGTGC
CTTTTAGGAGAAATAAAGAGGAAGTCCTGGCTGAGCAAGGTTGGAAGCCCTAGTTCTCGCATTGACCGCACAAACTTTTCTAATGAAAAA
ACCATCTCTAAGCTTGAATACTCTAATTTTAGTATTAGATACTAATAGAAGAGAAAAATTGTAACACACTGAACAATAGATACTGTATGT

>In-frame_ENST00000378239_ENST00000607452_TCGA-EJ-5515-01A_ERLEC1_chr2_54028979_+_ACYP2_chr2_54531825_length(amino acids)=303AA_start in transcript=131_stop in transcript=1042
MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEE
EEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKN
IEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ERLEC1-ACYP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ERLEC1-ACYP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ERLEC1-ACYP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERLEC1C0008370Cholestasis1CTD_human
HgeneERLEC1C0019193Hepatitis, Toxic1CTD_human
HgeneERLEC1C0860207Drug-Induced Liver Disease1CTD_human
HgeneERLEC1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneERLEC1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneERLEC1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneERLEC1C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneACYP2C2750088HEARING LOSS, CISPLATIN-INDUCED, SUSCEPTIBILITY TO1CTD_human