|
Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ESCO2-EPHX2 (FusionGDB2 ID:27479) |
Fusion Gene Summary for ESCO2-EPHX2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ESCO2-EPHX2 | Fusion gene ID: 27479 | Hgene | Tgene | Gene symbol | ESCO2 | EPHX2 | Gene ID | 157570 | 2053 |
Gene name | establishment of sister chromatid cohesion N-acetyltransferase 2 | epoxide hydrolase 2 | |
Synonyms | 2410004I17Rik|EFO2|EFO2p|RBS|hEFO2 | ABHD20|CEH|SEH | |
Cytomap | 8p21.1 | 8p21.2-p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | N-acetyltransferase ESCO2ECO1 homolog 2establishment factor-like protein 2 | bifunctional epoxide hydrolase 2epoxide hydrataseepoxide hydrolase 2, cytoplasmicepoxide hydrolase 2, cytosolicepoxide hydrolase, soluble | |
Modification date | 20200328 | 20200327 | |
UniProtAcc | . | P34913 | |
Ensembl transtripts involved in fusion gene | ENST00000305188, ENST00000397418, ENST00000523910, | ENST00000521400, ENST00000517536, ENST00000521780, ENST00000380476, ENST00000518379, ENST00000520666, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 3=48 |
# samples | 3 | 4 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ESCO2 [Title/Abstract] AND EPHX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ESCO2(27646495)-EPHX2(27394301), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | EPHX2 | GO:0010628 | positive regulation of gene expression | 18974052 |
Tgene | EPHX2 | GO:0016311 | dephosphorylation | 12574508 |
Tgene | EPHX2 | GO:0042632 | cholesterol homeostasis | 18974052 |
Tgene | EPHX2 | GO:0046272 | stilbene catabolic process | 8342951 |
Tgene | EPHX2 | GO:0046839 | phospholipid dephosphorylation | 12574510 |
Tgene | EPHX2 | GO:0097176 | epoxide metabolic process | 22798687 |
Fusion gene breakpoints across ESCO2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across EPHX2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-23-1027-01A | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
Top |
Fusion Gene ORF analysis for ESCO2-EPHX2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000305188 | ENST00000521400 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
In-frame | ENST00000305188 | ENST00000517536 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
In-frame | ENST00000305188 | ENST00000521780 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
In-frame | ENST00000305188 | ENST00000380476 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
In-frame | ENST00000305188 | ENST00000518379 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
5CDS-intron | ENST00000305188 | ENST00000520666 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
In-frame | ENST00000397418 | ENST00000521400 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
In-frame | ENST00000397418 | ENST00000517536 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
In-frame | ENST00000397418 | ENST00000521780 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
In-frame | ENST00000397418 | ENST00000380476 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
In-frame | ENST00000397418 | ENST00000518379 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
5CDS-intron | ENST00000397418 | ENST00000520666 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
intron-3CDS | ENST00000523910 | ENST00000521400 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
intron-3CDS | ENST00000523910 | ENST00000517536 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
intron-3CDS | ENST00000523910 | ENST00000521780 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
intron-3CDS | ENST00000523910 | ENST00000380476 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
intron-3CDS | ENST00000523910 | ENST00000518379 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
intron-intron | ENST00000523910 | ENST00000520666 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000305188 | ESCO2 | chr8 | 27646495 | - | ENST00000521400 | EPHX2 | chr8 | 27394301 | + | 3041 | 1501 | 31 | 1998 | 655 |
ENST00000305188 | ESCO2 | chr8 | 27646495 | - | ENST00000517536 | EPHX2 | chr8 | 27394301 | + | 2396 | 1501 | 31 | 1998 | 655 |
ENST00000305188 | ESCO2 | chr8 | 27646495 | - | ENST00000521780 | EPHX2 | chr8 | 27394301 | + | 2396 | 1501 | 31 | 1998 | 655 |
ENST00000305188 | ESCO2 | chr8 | 27646495 | - | ENST00000380476 | EPHX2 | chr8 | 27394301 | + | 2390 | 1501 | 31 | 1998 | 655 |
ENST00000305188 | ESCO2 | chr8 | 27646495 | - | ENST00000518379 | EPHX2 | chr8 | 27394301 | + | 2369 | 1501 | 31 | 1998 | 655 |
ENST00000397418 | ESCO2 | chr8 | 27646495 | - | ENST00000521400 | EPHX2 | chr8 | 27394301 | + | 2721 | 1181 | 13 | 942 | 309 |
ENST00000397418 | ESCO2 | chr8 | 27646495 | - | ENST00000517536 | EPHX2 | chr8 | 27394301 | + | 2076 | 1181 | 13 | 942 | 309 |
ENST00000397418 | ESCO2 | chr8 | 27646495 | - | ENST00000521780 | EPHX2 | chr8 | 27394301 | + | 2076 | 1181 | 13 | 942 | 309 |
ENST00000397418 | ESCO2 | chr8 | 27646495 | - | ENST00000380476 | EPHX2 | chr8 | 27394301 | + | 2070 | 1181 | 13 | 942 | 309 |
ENST00000397418 | ESCO2 | chr8 | 27646495 | - | ENST00000518379 | EPHX2 | chr8 | 27394301 | + | 2049 | 1181 | 13 | 942 | 309 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000305188 | ENST00000521400 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.002356847 | 0.9976432 |
ENST00000305188 | ENST00000517536 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.001808681 | 0.9981913 |
ENST00000305188 | ENST00000521780 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.001808681 | 0.9981913 |
ENST00000305188 | ENST00000380476 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.001805676 | 0.9981943 |
ENST00000305188 | ENST00000518379 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.001871796 | 0.99812824 |
ENST00000397418 | ENST00000521400 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.006964768 | 0.9930353 |
ENST00000397418 | ENST00000517536 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.006571763 | 0.9934282 |
ENST00000397418 | ENST00000521780 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.006571763 | 0.9934282 |
ENST00000397418 | ENST00000380476 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.006797409 | 0.99320257 |
ENST00000397418 | ENST00000518379 | ESCO2 | chr8 | 27646495 | - | EPHX2 | chr8 | 27394301 | + | 0.006902733 | 0.99309725 |
Top |
Fusion Genomic Features for ESCO2-EPHX2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for ESCO2-EPHX2 |
Go to FGviewer for the breakpoints of chr8:27646495-chr8:27394301 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | EPHX2 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687, PubMed:21217101). {ECO:0000250|UniProtKB:P80299, ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:12869654, ECO:0000269|PubMed:21217101, ECO:0000269|PubMed:22798687}.; FUNCTION: Bifunctional enzyme (PubMed:12574510). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (PubMed:22217705, PubMed:22387545). {ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ESCO2 | chr8:27646495 | chr8:27394301 | ENST00000305188 | - | 7 | 11 | 387_411 | 421.0 | 602.0 | Zinc finger | Note=CCHH-type |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | 11 | 19 | 553_555 | 337.0 | 503.0 | Motif | Microbody targeting signal | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | 11 | 19 | 553_555 | 390.0 | 556.0 | Motif | Microbody targeting signal | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | 10 | 18 | 553_555 | 324.0 | 490.0 | Motif | Microbody targeting signal |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | 11 | 19 | 259_531 | 337.0 | 503.0 | Domain | AB hydrolase-1 | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | 11 | 19 | 259_531 | 390.0 | 556.0 | Domain | AB hydrolase-1 | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | 10 | 18 | 259_531 | 324.0 | 490.0 | Domain | AB hydrolase-1 | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | 11 | 19 | 123_124 | 337.0 | 503.0 | Region | Phosphate binding | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | 11 | 19 | 1_224 | 337.0 | 503.0 | Region | Note=Phosphatase | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000380476 | 11 | 19 | 235_555 | 337.0 | 503.0 | Region | Note=Epoxide hydrolase | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | 11 | 19 | 123_124 | 390.0 | 556.0 | Region | Phosphate binding | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | 11 | 19 | 1_224 | 390.0 | 556.0 | Region | Note=Phosphatase | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521400 | 11 | 19 | 235_555 | 390.0 | 556.0 | Region | Note=Epoxide hydrolase | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | 10 | 18 | 123_124 | 324.0 | 490.0 | Region | Phosphate binding | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | 10 | 18 | 1_224 | 324.0 | 490.0 | Region | Note=Phosphatase | |
Tgene | EPHX2 | chr8:27646495 | chr8:27394301 | ENST00000521780 | 10 | 18 | 235_555 | 324.0 | 490.0 | Region | Note=Epoxide hydrolase |
Top |
Fusion Gene Sequence for ESCO2-EPHX2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000305188_ENST00000521400_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=3041nt_BP=1501nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT AGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATGACTATGCTGCTGGCTGTCTTTGTTCTTGGAGAGGTGGAGT GACTGTTCACGGAGAATGCACGGCATGGGGATGAACCCTTTCCCTCTGCTTTTGAGCCCTGTTCTGGGCTCCAAGGTGCTGTATGATCTA GGCCGTGCTGGCCAGGAGACAATCCTATGGGGATGGCAGTGGTGTCTTGTGCTCTGTCCCCTAGAGCAGTCACTGGCCACAGGTAGCCAC CTGCCTTTCTCCCGGCTTCCCTAGCAGAGTTTGCTCAGGCACAAATGTGCACCTGGAGCATTTGAAATGTGCTAGTGAGGCTGAGGAAGA GAATTTTAAATTTCATTGAATTGTAATCAGTTTAAAGTTAAATAGCAGCAGCTGCCATGAGGCTCAGGCAGATCCAGCTCATCTTCCCCT CTGCCCCCTCCTCCCTATCTTCCCCTCTACCCTCTCCTGCCTCCTGTCACATCCGGTTAGGCTCCCATCTCACTGATGTGTCTCCTGCAG TGGTCTCTCCCCTGCCCTGCTTCCAGCCCCAGAGTCCTGGAGCAGCAGCCTCCTCACGGGTCTTGCCGCCCACATGGTTGGATCCTGAAA >In-frame_ENST00000305188_ENST00000521400_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=655AA_start in transcript=31_stop in transcript=1998 METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK -------------------------------------------------------------- >In-frame_ENST00000305188_ENST00000517536_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=2396nt_BP=1501nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT >In-frame_ENST00000305188_ENST00000517536_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=655AA_start in transcript=31_stop in transcript=1998 METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK -------------------------------------------------------------- >In-frame_ENST00000305188_ENST00000521780_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=2396nt_BP=1501nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT >In-frame_ENST00000305188_ENST00000521780_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=655AA_start in transcript=31_stop in transcript=1998 METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK -------------------------------------------------------------- >In-frame_ENST00000305188_ENST00000380476_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=2390nt_BP=1501nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT >In-frame_ENST00000305188_ENST00000380476_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=655AA_start in transcript=31_stop in transcript=1998 METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK -------------------------------------------------------------- >In-frame_ENST00000305188_ENST00000518379_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=2369nt_BP=1501nt AGATTTTTCACCTCACCAGGGCGCGAGAATCTTGGAAACAGCCACCAGGGTGGGCGGGGCAAGGGCTGGTGCTCCACCAATCACCGAGCC AGCCCCTGGAAGCGCTGAGCCGTGGCCAATCGGAACGCAGCGGCTTCCTCCTAGCCTGGCGCGCGATTATTTGAAGACGCTCACGGAGCG GCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAGGAAGAGGAAGCA GGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTATCAAAACAGTGA TAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAGACTGCCATCAGC AAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACTGGAGAGAAAGCT GATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCAAGGAAAACCAGT CTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCCTGTATCAAGGAA TTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAATAATTCCAATGC TCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATCTTCTCTTAGAAA ATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGAGACTGTCAGTGA AAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGCAAGCAGTAAAAA TAAAGAGAAATTAATAAAGGATTCATCAGATGACAGAGTTTCTTCAAAGGAACATAAAGTTGATAAAAATGAGGCTTTTTCTTCAGAGGA TTCTCTTGGTGAGAATAAGACAATTTCTCCTAAGTCCACTGTCTATCCAATCTTCAGTGCATCTTCAGTCAATTCAAAAAGATCTTTAGG TGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATATCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAAC AAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTGTGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCC TGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAATCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAA CCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTTTATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGT AAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAATCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAG AGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTTGCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGAT GGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACATGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGA GGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGATCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACC GGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACA GAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATC AAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTT AGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTT >In-frame_ENST00000305188_ENST00000518379_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=655AA_start in transcript=31_stop in transcript=1998 METATRVGGARAGAPPITEPAPGSAEPWPIGTQRLPPSLARDYLKTLTERLARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLH FTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLK TNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKP QVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSD DRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQ KHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSR MVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDK -------------------------------------------------------------- >In-frame_ENST00000397418_ENST00000521400_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=2721nt_BP=1181nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG ACTATGCTGCTGGCTGTCTTTGTTCTTGGAGAGGTGGAGTGACTGTTCACGGAGAATGCACGGCATGGGGATGAACCCTTTCCCTCTGCT TTTGAGCCCTGTTCTGGGCTCCAAGGTGCTGTATGATCTAGGCCGTGCTGGCCAGGAGACAATCCTATGGGGATGGCAGTGGTGTCTTGT GCTCTGTCCCCTAGAGCAGTCACTGGCCACAGGTAGCCACCTGCCTTTCTCCCGGCTTCCCTAGCAGAGTTTGCTCAGGCACAAATGTGC ACCTGGAGCATTTGAAATGTGCTAGTGAGGCTGAGGAAGAGAATTTTAAATTTCATTGAATTGTAATCAGTTTAAAGTTAAATAGCAGCA GCTGCCATGAGGCTCAGGCAGATCCAGCTCATCTTCCCCTCTGCCCCCTCCTCCCTATCTTCCCCTCTACCCTCTCCTGCCTCCTGTCAC ATCCGGTTAGGCTCCCATCTCACTGATGTGTCTCCTGCAGTGGTCTCTCCCCTGCCCTGCTTCCAGCCCCAGAGTCCTGGAGCAGCAGCC TCCTCACGGGTCTTGCCGCCCACATGGTTGGATCCTGAAACTCGCAGGGCCTCCCCCAACTGCCCCTGCCCACCCCCAGCCCGGCCCCAT >In-frame_ENST00000397418_ENST00000521400_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=309AA_start in transcript=13_stop in transcript=942 MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE -------------------------------------------------------------- >In-frame_ENST00000397418_ENST00000517536_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=2076nt_BP=1181nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG >In-frame_ENST00000397418_ENST00000517536_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=309AA_start in transcript=13_stop in transcript=942 MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE -------------------------------------------------------------- >In-frame_ENST00000397418_ENST00000521780_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=2076nt_BP=1181nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG >In-frame_ENST00000397418_ENST00000521780_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=309AA_start in transcript=13_stop in transcript=942 MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE -------------------------------------------------------------- >In-frame_ENST00000397418_ENST00000380476_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=2070nt_BP=1181nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT GACCAATGCATAGTTTGGCAGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATG >In-frame_ENST00000397418_ENST00000380476_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=309AA_start in transcript=13_stop in transcript=942 MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE -------------------------------------------------------------- >In-frame_ENST00000397418_ENST00000518379_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(transcript)=2049nt_BP=1181nt GCTCACGGAGCGGCTGGCTAGGCTGAGGAGAGCTCGCCGGGCTCTGAGGCGCAGGAATTCAATAAAGAAAATGGCAGCTCTTACTCCAAG GAAGAGGAAGCAGGATTCTTTGAAGTGTGACAGCCTTTTACACTTCACTGAAAATCTGTTTCCATCACCTAATAAAAAGCACTGTTTTTA TCAAAACAGTGATAAAAATGAAGAAAACCTGCATTGCTCTCAACAAGAGCATTTTGTTTTAAGTGCGCTCAAAACAACTGAAATAAATAG ACTGCCATCAGCAAATCAAGGCTCACCATTTAAATCTGCGCTCTCCACTGTATCTTTTTACAACCAAAATAAGTGGTACCTCAATCCACT GGAGAGAAAGCTGATAAAAGAGAGTAGATCTACTTGTCTAAAAACTAATGATGAAGATAAATCTTTTCCCATTGTGACAGAAAAAATGCA AGGAAAACCAGTCTGCTCCAAGAAGAACAACAAAAAACCACAGAAGAGTTTAACTGCTAAGTATCAACCAAAGTATAGACACATCAAGCC TGTATCAAGGAATTCTAGAAATTCCAAGCAAAATCGAGTGATCTATAAGCCAATTGTGGAGAAGGAAAATAATTGTCATTCAGCTGAAAA TAATTCCAATGCTCCTCGGGTTCTGAGCCAAAAAATAAAACCACAAGTTACACTCCAGGGTGGAGCAGCATTTTTTGTTAGAAAAAAATC TTCTCTTAGAAAATCGTCCCTGGAAAATGAGCCGTCACTGGGACGCACCCAAAAGAGTAAATCAGAAGTCATTGAAGATTCTGATGTAGA GACTGTCAGTGAAAAAAAAACTTTTGCGACAAGGCAAGTGCCAAAGTGCTTGGTCCTAGAAGAGAAATTGAAAATTGGACTACTGAGTGC AAGCAGTAAAAATAAAGAGAAATTAATAAAGATCTTTAGGTGAAGAACAGTTTTCTGTGGGATCTGTCAACTTCATGAAACAGACCAATA TCCAGAAAAATACTAATACCAGAGATACAAGTAAAAAAACAAAAGACCAGCTCATCATCGACGCTGGTCAGAAACATTTTGGGGCTACTG TGTGCAAGTCTTGTGGTATGATATATACTGCTTCCAACCCTGAAGATGAAATGCAGCATGTACAGCATCACCACAGGTTTCTGGAAGGAA TCAAATATGTGGGAGTGGCTGAGGCTGAACTGGAACAGAACCTGAGTCGGACTTTCAAAAGCCTCTTCAGAGCAAGCGATGAGAGTGTTT TATCCATGCATAAAGTCTGTGAAGCGGGAGGACTTTTTGTAAATAGCCCAGAAGAGCCCAGCCTCAGCAGGATGGTCACTGAGGAGGAAA TCCAGTTCTATGTGCAGCAGTTCAAGAAGTCTGGTTTCAGAGGTCCTCTAAACTGGTACCGAAACATGGAAAGGAACTGGAAGTGGGCTT GCAAAAGCTTGGGACGGAAGATCCTGATTCCGGCCCTGATGGTCACGGCGGAGAAGGACTTCGTGCTCGTTCCTCAGATGTCCCAGCACA TGGAGGACTGGATTCCCCACCTGAAAAGGGGACACATTGAGGACTGTGGGCACTGGACACAGATGGACAAGCCAACCGAGGTGAATCAGA TCCTCATTAAGTGGCTGGATTCTGATGCCCGGAACCCACCGGTGGTCTCAAAGATGTAGAACGCAGCGTGTGCCCACGCTCAGCAGGTGT GCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCCTTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGG GTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAATCAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTC CAGGCATGAATGCATCGTCCCTTTATCTGTAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTT >In-frame_ENST00000397418_ENST00000518379_TCGA-23-1027-01A_ESCO2_chr8_27646495_-_EPHX2_chr8_27394301_length(amino acids)=309AA_start in transcript=13_stop in transcript=942 MARLRRARRALRRRNSIKKMAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSA NQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRN SRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSE -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for ESCO2-EPHX2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ESCO2-EPHX2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for ESCO2-EPHX2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ESCO2 | C0392475 | Roberts-SC phocomelia syndrome | 7 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | ESCO2 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
Hgene | ESCO2 | C0740457 | Malignant neoplasm of kidney | 1 | CTD_human |
Tgene | EPHX2 | C0013221 | Drug toxicity | 1 | CTD_human |
Tgene | EPHX2 | C0018801 | Heart failure | 1 | CTD_human |
Tgene | EPHX2 | C0018802 | Congestive heart failure | 1 | CTD_human |
Tgene | EPHX2 | C0022660 | Kidney Failure, Acute | 1 | CTD_human |
Tgene | EPHX2 | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
Tgene | EPHX2 | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
Tgene | EPHX2 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | EPHX2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Tgene | EPHX2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | EPHX2 | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
Tgene | EPHX2 | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
Tgene | EPHX2 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
Tgene | EPHX2 | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human |
Tgene | EPHX2 | C1959583 | Myocardial Failure | 1 | CTD_human |
Tgene | EPHX2 | C1961112 | Heart Decompensation | 1 | CTD_human |
Tgene | EPHX2 | C2609414 | Acute kidney injury | 1 | CTD_human |