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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ESR1-RFX4 (FusionGDB2 ID:27513)

Fusion Gene Summary for ESR1-RFX4

check button Fusion gene summary
Fusion gene informationFusion gene name: ESR1-RFX4
Fusion gene ID: 27513
HgeneTgene
Gene symbol

ESR1

RFX4

Gene ID

2099

5992

Gene nameestrogen receptor 1regulatory factor X4
SynonymsER|ESR|ESRA|ESTRR|Era|NR3A1NYD-SP10
Cytomap

6q25.1-q25.2

12q23.3

Type of geneprotein-codingprotein-coding
Descriptionestrogen receptorE2 receptor alphaER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1oestrogen receptor alphatranscription factor RFX4regulatory factor X, 4 (influences HLA class II expression)testis development protein NYD-SP10winged-helix transcription factor RFX4
Modification date2020032920200313
UniProtAcc

P03372

.
Ensembl transtripts involved in fusion geneENST00000440973, ENST00000338799, 
ENST00000456483, ENST00000443427, 
ENST00000206249, ENST00000406599, 
ENST00000427531, ENST00000482101, 
ENST00000392842, ENST00000357881, 
ENST00000229387, 
Fusion gene scores* DoF score21 X 18 X 8=30247 X 7 X 5=245
# samples 3510
** MAII scorelog2(35/3024*10)=-3.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/245*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESR1 [Title/Abstract] AND RFX4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointESR1(152201906)-RFX4(107033109), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESR1

GO:0006366

transcription by RNA polymerase II

15831516

HgeneESR1

GO:0010629

negative regulation of gene expression

21695196

HgeneESR1

GO:0030520

intracellular estrogen receptor signaling pathway

9841876

HgeneESR1

GO:0032355

response to estradiol

15304487

HgeneESR1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

7651415|16043358

HgeneESR1

GO:0043433

negative regulation of DNA-binding transcription factor activity

10816575

HgeneESR1

GO:0043627

response to estrogen

11581164

HgeneESR1

GO:0045893

positive regulation of transcription, DNA-templated

9841876|20074560

HgeneESR1

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

9841876

HgeneESR1

GO:0045944

positive regulation of transcription by RNA polymerase II

11544182|12047722|15345745|15831516|18563714

HgeneESR1

GO:0051091

positive regulation of DNA-binding transcription factor activity

9328340|10681512

HgeneESR1

GO:0071392

cellular response to estradiol stimulus

15831516

TgeneRFX4

GO:0045944

positive regulation of transcription by RNA polymerase II

16893423


check buttonFusion gene breakpoints across ESR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RFX4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AM69296ESR1chr6

152201906

+RFX4chr12

107033109

+


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Fusion Gene ORF analysis for ESR1-RFX4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000440973ENST00000392842ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000440973ENST00000357881ESR1chr6

152201906

+RFX4chr12

107033109

+
5CDS-intronENST00000440973ENST00000229387ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000338799ENST00000392842ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000338799ENST00000357881ESR1chr6

152201906

+RFX4chr12

107033109

+
5CDS-intronENST00000338799ENST00000229387ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000456483ENST00000392842ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000456483ENST00000357881ESR1chr6

152201906

+RFX4chr12

107033109

+
5CDS-intronENST00000456483ENST00000229387ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000443427ENST00000392842ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000443427ENST00000357881ESR1chr6

152201906

+RFX4chr12

107033109

+
5CDS-intronENST00000443427ENST00000229387ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000206249ENST00000392842ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000206249ENST00000357881ESR1chr6

152201906

+RFX4chr12

107033109

+
5CDS-intronENST00000206249ENST00000229387ESR1chr6

152201906

+RFX4chr12

107033109

+
intron-3CDSENST00000406599ENST00000392842ESR1chr6

152201906

+RFX4chr12

107033109

+
intron-3CDSENST00000406599ENST00000357881ESR1chr6

152201906

+RFX4chr12

107033109

+
intron-intronENST00000406599ENST00000229387ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000427531ENST00000392842ESR1chr6

152201906

+RFX4chr12

107033109

+
In-frameENST00000427531ENST00000357881ESR1chr6

152201906

+RFX4chr12

107033109

+
5CDS-intronENST00000427531ENST00000229387ESR1chr6

152201906

+RFX4chr12

107033109

+
intron-3CDSENST00000482101ENST00000392842ESR1chr6

152201906

+RFX4chr12

107033109

+
intron-3CDSENST00000482101ENST00000357881ESR1chr6

152201906

+RFX4chr12

107033109

+
intron-intronENST00000482101ENST00000229387ESR1chr6

152201906

+RFX4chr12

107033109

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440973ESR1chr6152201906+ENST00000392842RFX4chr12107033109+454111303703207945
ENST00000440973ESR1chr6152201906+ENST00000357881RFX4chr12107033109+339811303703207945
ENST00000338799ESR1chr6152201906+ENST00000392842RFX4chr12107033109+5631222014604297945
ENST00000338799ESR1chr6152201906+ENST00000357881RFX4chr12107033109+4488222014604297945
ENST00000456483ESR1chr6152201906+ENST00000392842RFX4chr12107033109+43899782183055945
ENST00000456483ESR1chr6152201906+ENST00000357881RFX4chr12107033109+32469782183055945
ENST00000443427ESR1chr6152201906+ENST00000392842RFX4chr12107033109+443210212613098945
ENST00000443427ESR1chr6152201906+ENST00000357881RFX4chr12107033109+328910212613098945
ENST00000206249ESR1chr6152201906+ENST00000392842RFX4chr12107033109+453311223623199945
ENST00000206249ESR1chr6152201906+ENST00000357881RFX4chr12107033109+339011223623199945
ENST00000427531ESR1chr6152201906+ENST00000392842RFX4chr12107033109+38844732052550781
ENST00000427531ESR1chr6152201906+ENST00000357881RFX4chr12107033109+27414732052550781

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440973ENST00000392842ESR1chr6152201906+RFX4chr12107033109+0.0005227310.9994773
ENST00000440973ENST00000357881ESR1chr6152201906+RFX4chr12107033109+0.0023977420.9976023
ENST00000338799ENST00000392842ESR1chr6152201906+RFX4chr12107033109+0.0011878430.9988122
ENST00000338799ENST00000357881ESR1chr6152201906+RFX4chr12107033109+0.0032978940.99670213
ENST00000456483ENST00000392842ESR1chr6152201906+RFX4chr12107033109+0.0004695670.99953043
ENST00000456483ENST00000357881ESR1chr6152201906+RFX4chr12107033109+0.002360650.9976394
ENST00000443427ENST00000392842ESR1chr6152201906+RFX4chr12107033109+0.0005022910.99949765
ENST00000443427ENST00000357881ESR1chr6152201906+RFX4chr12107033109+0.0024858770.9975141
ENST00000206249ENST00000392842ESR1chr6152201906+RFX4chr12107033109+0.0004543610.99954563
ENST00000206249ENST00000357881ESR1chr6152201906+RFX4chr12107033109+0.0020773040.9979227
ENST00000427531ENST00000392842ESR1chr6152201906+RFX4chr12107033109+0.0013579550.998642
ENST00000427531ENST00000357881ESR1chr6152201906+RFX4chr12107033109+0.0056825140.9943175

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Fusion Genomic Features for ESR1-RFX4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ESR1chr6152201906+RFX4chr12107033109+6.85E-050.99993145
ESR1chr6152201906+RFX4chr12107033109+6.85E-050.99993145

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ESR1-RFX4


check button Go to

FGviewer for the breakpoints of chr6:152201906-chr12:107033109

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESR1

P03372

.
FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1. {ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152201906chr12:107033109ENST00000206249+38185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr12:107033109ENST00000338799+49185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr12:107033109ENST00000440973+510185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr12:107033109ENST00000443427+49185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr12:107033109ENST00000456483+48185_250253.33333333333334484.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr12:107033109ENST00000206249+38185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr12:107033109ENST00000206249+38221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr12:107033109ENST00000338799+49185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr12:107033109ENST00000338799+49221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr12:107033109ENST00000440973+510185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr12:107033109ENST00000440973+510221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr12:107033109ENST00000443427+49185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr12:107033109ENST00000443427+49221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr12:107033109ENST00000456483+48185_205253.33333333333334484.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr12:107033109ENST00000456483+48221_245253.33333333333334484.0Zinc fingerNR C4-type
TgeneRFX4chr6:152201906chr12:107033109ENST0000022938701444_1260642.0DNA binding.
TgeneRFX4chr6:152201906chr12:107033109ENST0000022938701461_1360642.0DNA bindingRFX-type winged-helix
TgeneRFX4chr6:152201906chr12:107033109ENST0000035788111861_13652.333333333333336745.0DNA bindingRFX-type winged-helix
TgeneRFX4chr6:152201906chr12:107033109ENST0000039284211844_12643.333333333333336736.0DNA binding.
TgeneRFX4chr6:152201906chr12:107033109ENST0000039284211861_13643.333333333333336736.0DNA bindingRFX-type winged-helix
TgeneRFX4chr6:152201906chr12:107033109ENST00000229387014315_4870642.0RegionNote=Necessary for dimerization
TgeneRFX4chr6:152201906chr12:107033109ENST00000357881118315_48752.333333333333336745.0RegionNote=Necessary for dimerization
TgeneRFX4chr6:152201906chr12:107033109ENST00000392842118315_48743.333333333333336736.0RegionNote=Necessary for dimerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152201906chr12:107033109ENST00000206249+38311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201906chr12:107033109ENST00000338799+49311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201906chr12:107033109ENST00000440973+510311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201906chr12:107033109ENST00000443427+49311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201906chr12:107033109ENST00000456483+48311_547253.33333333333334484.0DomainNR LBD
HgeneESR1chr6:152201906chr12:107033109ENST00000206249+38251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr12:107033109ENST00000206249+38264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr12:107033109ENST00000206249+38311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr12:107033109ENST00000338799+49251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr12:107033109ENST00000338799+49264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr12:107033109ENST00000338799+49311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr12:107033109ENST00000440973+510251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr12:107033109ENST00000440973+510264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr12:107033109ENST00000440973+510311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr12:107033109ENST00000443427+49251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr12:107033109ENST00000443427+49264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr12:107033109ENST00000443427+49311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr12:107033109ENST00000456483+48251_310253.33333333333334484.0RegionNote=Hinge
HgeneESR1chr6:152201906chr12:107033109ENST00000456483+48264_595253.33333333333334484.0RegionNote=Self-association
HgeneESR1chr6:152201906chr12:107033109ENST00000456483+48311_595253.33333333333334484.0RegionNote=Transactivation AF-2
TgeneRFX4chr6:152201906chr12:107033109ENST0000035788111844_12652.333333333333336745.0DNA binding.


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Fusion Gene Sequence for ESR1-RFX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000440973_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=4541nt_BP=1130nt
ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAAACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGG
CTCGAAAGGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTCTGAGTGATAATCTTCTCTTCAAGAAGAAGAAAA
CTAGGAAGGAGTAAGCACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCACAGCACTTCTTGAAAAAGGATGTAGA
TTTTAATCTGAACTTTGAACCATCACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCG
GCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAA
CCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGG
CGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGC
GGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCT
GTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCC
GGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGA
ATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGC
CTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTG
CCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCAAGCCCCACTC
CACTCCTGCTACTCTGCAATGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATATGCATTACCT
GGATTTCTGCGAGAAGAATGATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGTTAACCACCAG
AAGACTCGGGACCCGAGGACAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGATGTATTCCAA
GAAAGGAGCTGCCTGGGTGAGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAACTCGGAACACT
GCTGCCAGAATTTCCCAATGTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGATGTACAGAAC
ACACTGTCAGAGAATACTGGACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAGGAATGCCGCC
CCACATGCTGCCTGTGCTGGGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCTCCGGGGTGCT
GATGCCCACTGTGCTGCAGGCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGCTAAAAGTGGC
TCTCCACGACCTCCCAGAAAACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAACATCACTAAA
TCATCTCTGCCAGGCATCTCGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGGACCTGAACAG
CATCACCAAGCAAACCCTTTACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGTTTGACCATCT
CTTGGAGGAGCAGTCTCCCATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTGCCAAGAGACA
AGGGTCCTTGAAGAAAGTGGCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCTTGCACAGCGC
CCCCAGCTTCGGGTCTTTTCACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTCAGGAGCGGGC
CAATGAGCTCATGCGAGCCATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCGCACCAACCCC
TTCACCAGTGCCATCGTTTTCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATCCTTCCCCTGA
GTACACTGGCCTCAGCACTACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGTCCCCAGCTGA
GAACTCCCAACAGCTGCCCTGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCCACAGAGAGGA
ACATGGATACACGGGAAGCTATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCCTCCCTCATGA
CACAGCTATCTCTGGGCCACTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCCGGATGGAACC
TTGTTTGATGAGCAGTACTCCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGTGCTACACAAG
CCCGTCTGTGCATTCTGCGAGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATGAGCACATGCA
ACACTTTCCTGGCTTTGCTTACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATATTTAATATTAA
TAATAATAATTAATAATAATAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCTATTCCTAAGT
GCCCATTTTCCTAATGAACATGAGGATGGGATCAATGTGGGATGAATAAACTTTAGTTCAGAAACAGGACTTACTAAAAGTCAGTGGGAC
TGGGTTTCTGTAGCCAAGCCAGACTTGACTGTTTCTGTAGAGCACTATCTCGGGCAGGCCATTCTGTGCCTTTTCCCTCTGTTCCATGAC
TTTGCTTTGTGTTGGCAACCACTTCTAGTAAGCTACTGATTTTCCTGTTGACAAAATCTCTTTAGTCTTGAAGGATGGATACTGGAGACA
GAATCTGGTTTGTGTTCTTGGATGGGCACATAATTTACCAAGAGCATTCACCTTGCCATCTGTCTTGTCATTGTACTGTACAAGGAACAG
CCCTCAGACGTGTTCTGCACATCCCTTCTTCCTGGTGGTACCATCCCTATTTCCTGGAGCACCAGGGCTAAATGGGGAGCTATCTGGAAA
CTCTAGATTTTCTGTCATACCCACATCTGTCACAGTACCTGCATTGTCTTGGAATGTAAGCACTGTCTTGAGGGAAGGAAGAGGTCTGTT
CTGTATTGCCTTAAGTTGATTGAGGTTTGTAGGAGACTGGTTCTTCTACATACAAGGATTTGTCTTAAGTTTGCACAATGGCTAGTGTCA
GCAAAAGGCAGGAGAGGGTTTTTGTTTTTTTTTTAAGTTCTATGAGAATGTGGATTTATGGCATTGAGTATCACACTCAGCTCTGCTGTG
TTAACTTTGTGAAACTGGATGGAACAAACTTTAACTTACCAAGCACCAAGTGTGAAAGTGACTTTCACGGTTCCTTCATAAAACTATAAT
AATATCCGACACTTTGATAGAAAAAAATTCAAAGCTGTGCCTTTGAGCCTATACTATACTGTGTATGTGTGGAAATAAAAATGTATTGTA
CTTTTGGAGAATTTTTTGTAGGCATTTTTCTGTCAGATTTGTAGTAATTTGTGAGGTTTGTTAGAGATTAATATAGGTTTTCTTTCTGTA
TTATAAAATGCACCAAGCAATTATGGTGGACCTATTACCCTATGGGTAAGAAATAAATGGAAATATGACATCGGATGTTTCAGCAACTGT
TCTGTAAATAAAATCTTTGATCACACCACTCAGTGTGATAATTGTGTCTACAGCTAAAATGGAAATAGTTTTATCTGTACAGTTGTGCAA

>In-frame_ENST00000440973_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=370_stop in transcript=3207
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000440973_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=3398nt_BP=1130nt
ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAAACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGG
CTCGAAAGGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTCTGAGTGATAATCTTCTCTTCAAGAAGAAGAAAA
CTAGGAAGGAGTAAGCACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCACAGCACTTCTTGAAAAAGGATGTAGA
TTTTAATCTGAACTTTGAACCATCACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCG
GCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAA
CCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGG
CGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGC
GGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCT
GTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCC
GGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGA
ATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGC
CTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTG
CCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCAAGCCCCACTC
CACTCCTGCTACTCTGCAATGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATATGCATTACCT
GGATTTCTGCGAGAAGAATGATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGTTAACCACCAG
AAGACTCGGGACCCGAGGACAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGATGTATTCCAA
GAAAGGAGCTGCCTGGGTGAGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAACTCGGAACACT
GCTGCCAGAATTTCCCAATGTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGATGTACAGAAC
ACACTGTCAGAGAATACTGGACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAGGAATGCCGCC
CCACATGCTGCCTGTGCTGGGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCTCCGGGGTGCT
GATGCCCACTGTGCTGCAGGCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGCTAAAAGTGGC
TCTCCACGACCTCCCAGAAAACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAACATCACTAAA
TCATCTCTGCCAGGCATCTCGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGGACCTGAACAG
CATCACCAAGCAAACCCTTTACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGTTTGACCATCT
CTTGGAGGAGCAGTCTCCCATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTGCCAAGAGACA
AGGGTCCTTGAAGAAAGTGGCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCTTGCACAGCGC
CCCCAGCTTCGGGTCTTTTCACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTCAGGAGCGGGC
CAATGAGCTCATGCGAGCCATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCGCACCAACCCC
TTCACCAGTGCCATCGTTTTCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATCCTTCCCCTGA
GTACACTGGCCTCAGCACTACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGTCCCCAGCTGA
GAACTCCCAACAGCTGCCCTGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCCACAGAGAGGA
ACATGGATACACGGGAAGCTATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCCTCCCTCATGA
CACAGCTATCTCTGGGCCACTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCCGGATGGAACC
TTGTTTGATGAGCAGTACTCCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGTGCTACACAAG
CCCGTCTGTGCATTCTGCGAGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATGAGCACATGCA
ACACTTTCCTGGCTTTGCTTACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATATTTAATATTAA
TAATAATAATTAATAATAATAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCTATTCCTAAGT

>In-frame_ENST00000440973_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=370_stop in transcript=3207
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000338799_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=5631nt_BP=2220nt
CTAGAGCATGGGTGGCCATTGTTGACCTACAGGAGGCACCACTGTCACCAACAAAGGGTAACAGTCTTTCTTTTCAATATTTATTTATAT
CCAGTATTTATTTTCAATACTGACTATGGAGAGAGCTCTCCTGTGCTCAAACACTGCAATACTGGGGGTCTTTCAAAGCACAAAAACATA
TATTTGCATGATGGCATCATTAACATTTTTATGGCTTTCTATTTCTTTTTTGTACTGGTCTCAAGAGCCACTCATAAATCTCTCAGTAAC
TGCATAGTGTCCCAGGGCCAGAGACCGGCCACTCCTGGCATTGTGATTAGAGTCATTTAATATCCAAGGTGGTGACTAATGTCTGGCAAC
AAAGCCTCCATTGGGTGTCATGTGTCCTGGGACCCTGAGCGTGGGCACTCTAGGAGCACCTCAGTATTGCGTGTTAGTACTATGGCCGAG
AGAATAGTTGAGAAAGTGGTCAAGAGGTGGATCCATGTGAACGCCACTGGGAAATGAGAGACCTCGTTCCCAATCACGGTCAGTGCAACT
CGAAAGCCTAAAATCAGTTTAAAACAAAGGTATCTACCTTTATCTTATGTTCATATCCTAGGCTTTTAATAATACGTATTTTTCACATGT
TTACAGAAAGCAGTCAACTGAGCTATTCATGGAAAGGTTTGTGGGTTTGGTTAACGAAGTGGAGGAGTATTACATTTCAGCTGGAAACAC
ATCCCTAGAATGCCAAAACATTTATTCCAAAGTCTGGTTTCCTGGTGCAATCGGAGGCATGGCAATGCCTCTGTTCAGAGACTGGGGGCT
AGGGCCAGTAAGGCATTTGATCCACATGTATCCCAGAAGGCTTTTATTGTTAAATTATATTCTTTCGGAAAAACCACCCATGTCCTATTT
TGTAAACTTGATATCCATACACTTTTGACTGGCATTCTATTTTAGCCGTAAGACTATGATTCACAGCAAGCCTGTTTTTCCTCTTGCTTG
GGGTGGCAGCAGAAAGCATAGGGTACTTTCCAGCCTCCAAGGGTAGGGGCAAAGGGGCTGGGGTTTCTCCTCCCCAGTACAGCTTTCTCT
GGCTGTGCCACACTGCTCCCTGTGAGCAGACAGCAAGTCTCCCCTCACTCCCCACTGCCATTCATCCAGCGCTGTGCAGTAGCCCAGCTG
CGTGTCTGCCGGGAGGGGCTGCCAAGTGCCCTGCCTACTGGCTGCTTCCCGAATCCCTGCCATTCCACGCACAAACACATCCACACACTC
TCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGGCCCTTGACTTCTACAAGC
CCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCAC
CCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGG
AGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACT
ACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGT
CTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGC
CGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGG
CCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTA
TGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGG
GCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGA
GGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCA
AGCCCCACTCCACTCCTGCTACTCTGCAATGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATA
TGCATTACCTGGATTTCTGCGAGAAGAATGATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGT
TAACCACCAGAAGACTCGGGACCCGAGGACAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGA
TGTATTCCAAGAAAGGAGCTGCCTGGGTGAGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAAC
TCGGAACACTGCTGCCAGAATTTCCCAATGTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGA
TGTACAGAACACACTGTCAGAGAATACTGGACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAG
GAATGCCGCCCCACATGCTGCCTGTGCTGGGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCT
CCGGGGTGCTGATGCCCACTGTGCTGCAGGCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGC
TAAAAGTGGCTCTCCACGACCTCCCAGAAAACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAA
CATCACTAAATCATCTCTGCCAGGCATCTCGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGG
ACCTGAACAGCATCACCAAGCAAACCCTTTACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGT
TTGACCATCTCTTGGAGGAGCAGTCTCCCATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTG
CCAAGAGACAAGGGTCCTTGAAGAAAGTGGCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCT
TGCACAGCGCCCCCAGCTTCGGGTCTTTTCACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTC
AGGAGCGGGCCAATGAGCTCATGCGAGCCATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCG
CACCAACCCCTTCACCAGTGCCATCGTTTTCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATC
CTTCCCCTGAGTACACTGGCCTCAGCACTACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGT
CCCCAGCTGAGAACTCCCAACAGCTGCCCTGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCC
ACAGAGAGGAACATGGATACACGGGAAGCTATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCC
TCCCTCATGACACAGCTATCTCTGGGCCACTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCC
GGATGGAACCTTGTTTGATGAGCAGTACTCCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGT
GCTACACAAGCCCGTCTGTGCATTCTGCGAGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATG
AGCACATGCAACACTTTCCTGGCTTTGCTTACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATAT
TTAATATTAATAATAATAATTAATAATAATAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCT
ATTCCTAAGTGCCCATTTTCCTAATGAACATGAGGATGGGATCAATGTGGGATGAATAAACTTTAGTTCAGAAACAGGACTTACTAAAAG
TCAGTGGGACTGGGTTTCTGTAGCCAAGCCAGACTTGACTGTTTCTGTAGAGCACTATCTCGGGCAGGCCATTCTGTGCCTTTTCCCTCT
GTTCCATGACTTTGCTTTGTGTTGGCAACCACTTCTAGTAAGCTACTGATTTTCCTGTTGACAAAATCTCTTTAGTCTTGAAGGATGGAT
ACTGGAGACAGAATCTGGTTTGTGTTCTTGGATGGGCACATAATTTACCAAGAGCATTCACCTTGCCATCTGTCTTGTCATTGTACTGTA
CAAGGAACAGCCCTCAGACGTGTTCTGCACATCCCTTCTTCCTGGTGGTACCATCCCTATTTCCTGGAGCACCAGGGCTAAATGGGGAGC
TATCTGGAAACTCTAGATTTTCTGTCATACCCACATCTGTCACAGTACCTGCATTGTCTTGGAATGTAAGCACTGTCTTGAGGGAAGGAA
GAGGTCTGTTCTGTATTGCCTTAAGTTGATTGAGGTTTGTAGGAGACTGGTTCTTCTACATACAAGGATTTGTCTTAAGTTTGCACAATG
GCTAGTGTCAGCAAAAGGCAGGAGAGGGTTTTTGTTTTTTTTTTAAGTTCTATGAGAATGTGGATTTATGGCATTGAGTATCACACTCAG
CTCTGCTGTGTTAACTTTGTGAAACTGGATGGAACAAACTTTAACTTACCAAGCACCAAGTGTGAAAGTGACTTTCACGGTTCCTTCATA
AAACTATAATAATATCCGACACTTTGATAGAAAAAAATTCAAAGCTGTGCCTTTGAGCCTATACTATACTGTGTATGTGTGGAAATAAAA
ATGTATTGTACTTTTGGAGAATTTTTTGTAGGCATTTTTCTGTCAGATTTGTAGTAATTTGTGAGGTTTGTTAGAGATTAATATAGGTTT
TCTTTCTGTATTATAAAATGCACCAAGCAATTATGGTGGACCTATTACCCTATGGGTAAGAAATAAATGGAAATATGACATCGGATGTTT
CAGCAACTGTTCTGTAAATAAAATCTTTGATCACACCACTCAGTGTGATAATTGTGTCTACAGCTAAAATGGAAATAGTTTTATCTGTAC

>In-frame_ENST00000338799_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=1460_stop in transcript=4297
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000338799_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=4488nt_BP=2220nt
CTAGAGCATGGGTGGCCATTGTTGACCTACAGGAGGCACCACTGTCACCAACAAAGGGTAACAGTCTTTCTTTTCAATATTTATTTATAT
CCAGTATTTATTTTCAATACTGACTATGGAGAGAGCTCTCCTGTGCTCAAACACTGCAATACTGGGGGTCTTTCAAAGCACAAAAACATA
TATTTGCATGATGGCATCATTAACATTTTTATGGCTTTCTATTTCTTTTTTGTACTGGTCTCAAGAGCCACTCATAAATCTCTCAGTAAC
TGCATAGTGTCCCAGGGCCAGAGACCGGCCACTCCTGGCATTGTGATTAGAGTCATTTAATATCCAAGGTGGTGACTAATGTCTGGCAAC
AAAGCCTCCATTGGGTGTCATGTGTCCTGGGACCCTGAGCGTGGGCACTCTAGGAGCACCTCAGTATTGCGTGTTAGTACTATGGCCGAG
AGAATAGTTGAGAAAGTGGTCAAGAGGTGGATCCATGTGAACGCCACTGGGAAATGAGAGACCTCGTTCCCAATCACGGTCAGTGCAACT
CGAAAGCCTAAAATCAGTTTAAAACAAAGGTATCTACCTTTATCTTATGTTCATATCCTAGGCTTTTAATAATACGTATTTTTCACATGT
TTACAGAAAGCAGTCAACTGAGCTATTCATGGAAAGGTTTGTGGGTTTGGTTAACGAAGTGGAGGAGTATTACATTTCAGCTGGAAACAC
ATCCCTAGAATGCCAAAACATTTATTCCAAAGTCTGGTTTCCTGGTGCAATCGGAGGCATGGCAATGCCTCTGTTCAGAGACTGGGGGCT
AGGGCCAGTAAGGCATTTGATCCACATGTATCCCAGAAGGCTTTTATTGTTAAATTATATTCTTTCGGAAAAACCACCCATGTCCTATTT
TGTAAACTTGATATCCATACACTTTTGACTGGCATTCTATTTTAGCCGTAAGACTATGATTCACAGCAAGCCTGTTTTTCCTCTTGCTTG
GGGTGGCAGCAGAAAGCATAGGGTACTTTCCAGCCTCCAAGGGTAGGGGCAAAGGGGCTGGGGTTTCTCCTCCCCAGTACAGCTTTCTCT
GGCTGTGCCACACTGCTCCCTGTGAGCAGACAGCAAGTCTCCCCTCACTCCCCACTGCCATTCATCCAGCGCTGTGCAGTAGCCCAGCTG
CGTGTCTGCCGGGAGGGGCTGCCAAGTGCCCTGCCTACTGGCTGCTTCCCGAATCCCTGCCATTCCACGCACAAACACATCCACACACTC
TCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGGCCCTTGACTTCTACAAGC
CCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCAC
CCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGG
AGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACT
ACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGT
CTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGC
CGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGG
CCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTA
TGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGG
GCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGA
GGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCA
AGCCCCACTCCACTCCTGCTACTCTGCAATGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATA
TGCATTACCTGGATTTCTGCGAGAAGAATGATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGT
TAACCACCAGAAGACTCGGGACCCGAGGACAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGA
TGTATTCCAAGAAAGGAGCTGCCTGGGTGAGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAAC
TCGGAACACTGCTGCCAGAATTTCCCAATGTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGA
TGTACAGAACACACTGTCAGAGAATACTGGACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAG
GAATGCCGCCCCACATGCTGCCTGTGCTGGGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCT
CCGGGGTGCTGATGCCCACTGTGCTGCAGGCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGC
TAAAAGTGGCTCTCCACGACCTCCCAGAAAACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAA
CATCACTAAATCATCTCTGCCAGGCATCTCGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGG
ACCTGAACAGCATCACCAAGCAAACCCTTTACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGT
TTGACCATCTCTTGGAGGAGCAGTCTCCCATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTG
CCAAGAGACAAGGGTCCTTGAAGAAAGTGGCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCT
TGCACAGCGCCCCCAGCTTCGGGTCTTTTCACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTC
AGGAGCGGGCCAATGAGCTCATGCGAGCCATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCG
CACCAACCCCTTCACCAGTGCCATCGTTTTCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATC
CTTCCCCTGAGTACACTGGCCTCAGCACTACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGT
CCCCAGCTGAGAACTCCCAACAGCTGCCCTGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCC
ACAGAGAGGAACATGGATACACGGGAAGCTATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCC
TCCCTCATGACACAGCTATCTCTGGGCCACTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCC
GGATGGAACCTTGTTTGATGAGCAGTACTCCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGT
GCTACACAAGCCCGTCTGTGCATTCTGCGAGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATG
AGCACATGCAACACTTTCCTGGCTTTGCTTACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATAT
TTAATATTAATAATAATAATTAATAATAATAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCT

>In-frame_ENST00000338799_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=1460_stop in transcript=4297
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000456483_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=4389nt_BP=978nt
AAACACATCCACACACTCTCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGG
CCCTTGACTTCTACAAGCCCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTG
CGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGA
TCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCA
AGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCC
TCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGC
TGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCG
GCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTA
CCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATG
GAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCA
CCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAG
AAAATAATAGAGCATCCAAGCCCCACTCCACTCCTGCTACTCTGCAATGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCC
CTCGCAGTGCCCTCTATATGCATTACCTGGATTTCTGCGAGAAGAATGATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAA
GGCAGCAGTTTCCTCAGTTAACCACCAGAAGACTCGGGACCCGAGGACAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCT
CCCAATATTATGATGTGATGTATTCCAAGAAAGGAGCTGCCTGGGTGAGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCAT
ATTCACCCCGGTCCAAACTCGGAACACTGCTGCCAGAATTTCCCAATGTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGG
TTTCTACCTTTATTATGATGTACAGAACACACTGTCAGAGAATACTGGACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCC
TTCTGCACTTTTGGCAAGGAATGCCGCCCCACATGCTGCCTGTGCTGGGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCA
TCCTCTACAAAGCTATCTCCGGGGTGCTGATGCCCACTGTGCTGCAGGCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCA
AGCAACTGGATGAGTGGCTAAAAGTGGCTCTCCACGACCTCCCAGAAAACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCC
AAATTCTGAGACGGCAAACATCACTAAATCATCTCTGCCAGGCATCTCGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGG
AAGACTGGAGGAACGTGGACCTGAACAGCATCACCAAGCAAACCCTTTACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCA
CCCAATTATATCAGGAGTTTGACCATCTCTTGGAGGAGCAGTCTCCCATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCT
GTGTTGTGAAGGTGGCTGCCAAGAGACAAGGGTCCTTGAAGAAAGTGGCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGG
TGATCCGGGACATGACCTTGCACAGCGCCCCCAGCTTCGGGTCTTTTCACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGT
TAGAATCTCTGCACTGTCAGGAGCGGGCCAATGAGCTCATGCGAGCCATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCA
TCTTGACAGAGGCTGCCGCACCAACCCCTTCACCAGTGCCATCGTTTTCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCT
CTTCCCCTGTTAGCAATCCTTCCCCTGAGTACACTGGCCTCAGCACTACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAG
TGACGACGGCTGCTGGGTCCCCAGCTGAGAACTCCCAACAGCTGCCCTGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACA
GGATACCAGTTTATCCCCACAGAGAGGAACATGGATACACGGGAAGCTATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGC
AGAGCCAGTATCCGGCCCTCCCTCATGACACAGCTATCTCTGGGCCACTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTT
TTAATAGCCCCACTTCCCGGATGGAACCTTGTTTGATGAGCAGTACTCCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGG
TGCCCTCAGCCAACACGTGCTACACAAGCCCGTCTGTGCATTCTGCGAGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGC
GCAGGAATTCTGAATATGAGCACATGCAACACTTTCCTGGCTTTGCTTACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGC
TATCATAGGCATCCATATTTAATATTAATAATAATAATTAATAATAATAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATA
CATTGTAACTCATGGGCTATTCCTAAGTGCCCATTTTCCTAATGAACATGAGGATGGGATCAATGTGGGATGAATAAACTTTAGTTCAGA
AACAGGACTTACTAAAAGTCAGTGGGACTGGGTTTCTGTAGCCAAGCCAGACTTGACTGTTTCTGTAGAGCACTATCTCGGGCAGGCCAT
TCTGTGCCTTTTCCCTCTGTTCCATGACTTTGCTTTGTGTTGGCAACCACTTCTAGTAAGCTACTGATTTTCCTGTTGACAAAATCTCTT
TAGTCTTGAAGGATGGATACTGGAGACAGAATCTGGTTTGTGTTCTTGGATGGGCACATAATTTACCAAGAGCATTCACCTTGCCATCTG
TCTTGTCATTGTACTGTACAAGGAACAGCCCTCAGACGTGTTCTGCACATCCCTTCTTCCTGGTGGTACCATCCCTATTTCCTGGAGCAC
CAGGGCTAAATGGGGAGCTATCTGGAAACTCTAGATTTTCTGTCATACCCACATCTGTCACAGTACCTGCATTGTCTTGGAATGTAAGCA
CTGTCTTGAGGGAAGGAAGAGGTCTGTTCTGTATTGCCTTAAGTTGATTGAGGTTTGTAGGAGACTGGTTCTTCTACATACAAGGATTTG
TCTTAAGTTTGCACAATGGCTAGTGTCAGCAAAAGGCAGGAGAGGGTTTTTGTTTTTTTTTTAAGTTCTATGAGAATGTGGATTTATGGC
ATTGAGTATCACACTCAGCTCTGCTGTGTTAACTTTGTGAAACTGGATGGAACAAACTTTAACTTACCAAGCACCAAGTGTGAAAGTGAC
TTTCACGGTTCCTTCATAAAACTATAATAATATCCGACACTTTGATAGAAAAAAATTCAAAGCTGTGCCTTTGAGCCTATACTATACTGT
GTATGTGTGGAAATAAAAATGTATTGTACTTTTGGAGAATTTTTTGTAGGCATTTTTCTGTCAGATTTGTAGTAATTTGTGAGGTTTGTT
AGAGATTAATATAGGTTTTCTTTCTGTATTATAAAATGCACCAAGCAATTATGGTGGACCTATTACCCTATGGGTAAGAAATAAATGGAA
ATATGACATCGGATGTTTCAGCAACTGTTCTGTAAATAAAATCTTTGATCACACCACTCAGTGTGATAATTGTGTCTACAGCTAAAATGG

>In-frame_ENST00000456483_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=218_stop in transcript=3055
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000456483_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=3246nt_BP=978nt
AAACACATCCACACACTCTCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGG
CCCTTGACTTCTACAAGCCCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTG
CGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGA
TCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCA
AGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCC
TCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGC
TGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCG
GCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTA
CCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATG
GAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCA
CCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAG
AAAATAATAGAGCATCCAAGCCCCACTCCACTCCTGCTACTCTGCAATGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCC
CTCGCAGTGCCCTCTATATGCATTACCTGGATTTCTGCGAGAAGAATGATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAA
GGCAGCAGTTTCCTCAGTTAACCACCAGAAGACTCGGGACCCGAGGACAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCT
CCCAATATTATGATGTGATGTATTCCAAGAAAGGAGCTGCCTGGGTGAGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCAT
ATTCACCCCGGTCCAAACTCGGAACACTGCTGCCAGAATTTCCCAATGTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGG
TTTCTACCTTTATTATGATGTACAGAACACACTGTCAGAGAATACTGGACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCC
TTCTGCACTTTTGGCAAGGAATGCCGCCCCACATGCTGCCTGTGCTGGGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCA
TCCTCTACAAAGCTATCTCCGGGGTGCTGATGCCCACTGTGCTGCAGGCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCA
AGCAACTGGATGAGTGGCTAAAAGTGGCTCTCCACGACCTCCCAGAAAACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCC
AAATTCTGAGACGGCAAACATCACTAAATCATCTCTGCCAGGCATCTCGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGG
AAGACTGGAGGAACGTGGACCTGAACAGCATCACCAAGCAAACCCTTTACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCA
CCCAATTATATCAGGAGTTTGACCATCTCTTGGAGGAGCAGTCTCCCATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCT
GTGTTGTGAAGGTGGCTGCCAAGAGACAAGGGTCCTTGAAGAAAGTGGCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGG
TGATCCGGGACATGACCTTGCACAGCGCCCCCAGCTTCGGGTCTTTTCACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGT
TAGAATCTCTGCACTGTCAGGAGCGGGCCAATGAGCTCATGCGAGCCATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCA
TCTTGACAGAGGCTGCCGCACCAACCCCTTCACCAGTGCCATCGTTTTCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCT
CTTCCCCTGTTAGCAATCCTTCCCCTGAGTACACTGGCCTCAGCACTACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAG
TGACGACGGCTGCTGGGTCCCCAGCTGAGAACTCCCAACAGCTGCCCTGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACA
GGATACCAGTTTATCCCCACAGAGAGGAACATGGATACACGGGAAGCTATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGC
AGAGCCAGTATCCGGCCCTCCCTCATGACACAGCTATCTCTGGGCCACTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTT
TTAATAGCCCCACTTCCCGGATGGAACCTTGTTTGATGAGCAGTACTCCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGG
TGCCCTCAGCCAACACGTGCTACACAAGCCCGTCTGTGCATTCTGCGAGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGC
GCAGGAATTCTGAATATGAGCACATGCAACACTTTCCTGGCTTTGCTTACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGC
TATCATAGGCATCCATATTTAATATTAATAATAATAATTAATAATAATAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATA
CATTGTAACTCATGGGCTATTCCTAAGTGCCCATTTTCCTAATGAACATGAGGATGGGATCAATGTGGGATGAATAAACTTTAGTTCAGA

>In-frame_ENST00000456483_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=218_stop in transcript=3055
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000443427_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=4432nt_BP=1021nt
GACAAACAGAGATATATCGGAGTCTGGCACGGGGCACATAAGGCAGCACATTAGAGAAAGCCGGCCCCTGGATCCGTCTTTCGCGTTTAT
TTTAAGCCCAGTCTTCCCTGGGCCACCTTTAGCAGATCCTCGTGCGCCCCCGCCCCCTGGCCGTGAAACTCAGCCTCTATCCAGCAGCGA
CGACAAGTAAAGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATG
ACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATC
CCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAAC
GCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGC
CTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCC
CACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAAT
TCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGC
TACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATT
CAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGT
AAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCAAGCCCCACTCCACTCCTGCTACTCTGCAA
TGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATATGCATTACCTGGATTTCTGCGAGAAGAAT
GATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGTTAACCACCAGAAGACTCGGGACCCGAGGA
CAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGATGTATTCCAAGAAAGGAGCTGCCTGGGTG
AGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAACTCGGAACACTGCTGCCAGAATTTCCCAAT
GTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGATGTACAGAACACACTGTCAGAGAATACTG
GACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAGGAATGCCGCCCCACATGCTGCCTGTGCTG
GGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCTCCGGGGTGCTGATGCCCACTGTGCTGCAG
GCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGCTAAAAGTGGCTCTCCACGACCTCCCAGAA
AACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAACATCACTAAATCATCTCTGCCAGGCATCT
CGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGGACCTGAACAGCATCACCAAGCAAACCCTT
TACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGTTTGACCATCTCTTGGAGGAGCAGTCTCCC
ATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTGCCAAGAGACAAGGGTCCTTGAAGAAAGTG
GCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCTTGCACAGCGCCCCCAGCTTCGGGTCTTTT
CACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTCAGGAGCGGGCCAATGAGCTCATGCGAGCC
ATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCGCACCAACCCCTTCACCAGTGCCATCGTTT
TCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATCCTTCCCCTGAGTACACTGGCCTCAGCACT
ACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGTCCCCAGCTGAGAACTCCCAACAGCTGCCC
TGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCCACAGAGAGGAACATGGATACACGGGAAGC
TATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCCTCCCTCATGACACAGCTATCTCTGGGCCA
CTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCCGGATGGAACCTTGTTTGATGAGCAGTACT
CCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGTGCTACACAAGCCCGTCTGTGCATTCTGCG
AGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATGAGCACATGCAACACTTTCCTGGCTTTGCT
TACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATATTTAATATTAATAATAATAATTAATAATAA
TAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCTATTCCTAAGTGCCCATTTTCCTAATGAAC
ATGAGGATGGGATCAATGTGGGATGAATAAACTTTAGTTCAGAAACAGGACTTACTAAAAGTCAGTGGGACTGGGTTTCTGTAGCCAAGC
CAGACTTGACTGTTTCTGTAGAGCACTATCTCGGGCAGGCCATTCTGTGCCTTTTCCCTCTGTTCCATGACTTTGCTTTGTGTTGGCAAC
CACTTCTAGTAAGCTACTGATTTTCCTGTTGACAAAATCTCTTTAGTCTTGAAGGATGGATACTGGAGACAGAATCTGGTTTGTGTTCTT
GGATGGGCACATAATTTACCAAGAGCATTCACCTTGCCATCTGTCTTGTCATTGTACTGTACAAGGAACAGCCCTCAGACGTGTTCTGCA
CATCCCTTCTTCCTGGTGGTACCATCCCTATTTCCTGGAGCACCAGGGCTAAATGGGGAGCTATCTGGAAACTCTAGATTTTCTGTCATA
CCCACATCTGTCACAGTACCTGCATTGTCTTGGAATGTAAGCACTGTCTTGAGGGAAGGAAGAGGTCTGTTCTGTATTGCCTTAAGTTGA
TTGAGGTTTGTAGGAGACTGGTTCTTCTACATACAAGGATTTGTCTTAAGTTTGCACAATGGCTAGTGTCAGCAAAAGGCAGGAGAGGGT
TTTTGTTTTTTTTTTAAGTTCTATGAGAATGTGGATTTATGGCATTGAGTATCACACTCAGCTCTGCTGTGTTAACTTTGTGAAACTGGA
TGGAACAAACTTTAACTTACCAAGCACCAAGTGTGAAAGTGACTTTCACGGTTCCTTCATAAAACTATAATAATATCCGACACTTTGATA
GAAAAAAATTCAAAGCTGTGCCTTTGAGCCTATACTATACTGTGTATGTGTGGAAATAAAAATGTATTGTACTTTTGGAGAATTTTTTGT
AGGCATTTTTCTGTCAGATTTGTAGTAATTTGTGAGGTTTGTTAGAGATTAATATAGGTTTTCTTTCTGTATTATAAAATGCACCAAGCA
ATTATGGTGGACCTATTACCCTATGGGTAAGAAATAAATGGAAATATGACATCGGATGTTTCAGCAACTGTTCTGTAAATAAAATCTTTG
ATCACACCACTCAGTGTGATAATTGTGTCTACAGCTAAAATGGAAATAGTTTTATCTGTACAGTTGTGCAAGATATGAATGGTTTCACAC

>In-frame_ENST00000443427_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=261_stop in transcript=3098
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000443427_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=3289nt_BP=1021nt
GACAAACAGAGATATATCGGAGTCTGGCACGGGGCACATAAGGCAGCACATTAGAGAAAGCCGGCCCCTGGATCCGTCTTTCGCGTTTAT
TTTAAGCCCAGTCTTCCCTGGGCCACCTTTAGCAGATCCTCGTGCGCCCCCGCCCCCTGGCCGTGAAACTCAGCCTCTATCCAGCAGCGA
CGACAAGTAAAGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATG
ACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATC
CCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAAC
GCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGC
CTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCC
CACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAAT
TCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGC
TACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATT
CAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGT
AAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCAAGCCCCACTCCACTCCTGCTACTCTGCAA
TGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATATGCATTACCTGGATTTCTGCGAGAAGAAT
GATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGTTAACCACCAGAAGACTCGGGACCCGAGGA
CAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGATGTATTCCAAGAAAGGAGCTGCCTGGGTG
AGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAACTCGGAACACTGCTGCCAGAATTTCCCAAT
GTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGATGTACAGAACACACTGTCAGAGAATACTG
GACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAGGAATGCCGCCCCACATGCTGCCTGTGCTG
GGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCTCCGGGGTGCTGATGCCCACTGTGCTGCAG
GCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGCTAAAAGTGGCTCTCCACGACCTCCCAGAA
AACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAACATCACTAAATCATCTCTGCCAGGCATCT
CGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGGACCTGAACAGCATCACCAAGCAAACCCTT
TACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGTTTGACCATCTCTTGGAGGAGCAGTCTCCC
ATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTGCCAAGAGACAAGGGTCCTTGAAGAAAGTG
GCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCTTGCACAGCGCCCCCAGCTTCGGGTCTTTT
CACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTCAGGAGCGGGCCAATGAGCTCATGCGAGCC
ATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCGCACCAACCCCTTCACCAGTGCCATCGTTT
TCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATCCTTCCCCTGAGTACACTGGCCTCAGCACT
ACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGTCCCCAGCTGAGAACTCCCAACAGCTGCCC
TGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCCACAGAGAGGAACATGGATACACGGGAAGC
TATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCCTCCCTCATGACACAGCTATCTCTGGGCCA
CTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCCGGATGGAACCTTGTTTGATGAGCAGTACT
CCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGTGCTACACAAGCCCGTCTGTGCATTCTGCG
AGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATGAGCACATGCAACACTTTCCTGGCTTTGCT
TACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATATTTAATATTAATAATAATAATTAATAATAA
TAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCTATTCCTAAGTGCCCATTTTCCTAATGAAC

>In-frame_ENST00000443427_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=261_stop in transcript=3098
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000206249_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=4533nt_BP=1122nt
GAGTTGTGCCTGGAGTGATGTTTAAGCCAATGTCAGGGCAAGGCAACAGTCCCTGGCCGTCCTCCAGCACCTTTGTAATGCATATGAGCT
CGGGAGACCAGTACTTAAAGTTGGAGGCCCGGGAGCCCAGGAGCTGGCGGAGGGCGTTCGTCCTGGGACTGCACTTGCTCCCGTCGGGTC
GCCCGGCTTCACCGGACCCGCAGGCTCCCGGGGCAGGGCCGGGGCCAGAGCTCGCGTGTCGGCGGGACATGCGCTGCGTCGCCTCTAACC
TCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGA
CCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGC
AGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCT
ACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCG
GCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT
TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCT
ACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCA
AGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCA
AGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCT
GCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCAAGCCCCACTCCACTCCTG
CTACTCTGCAATGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATATGCATTACCTGGATTTCT
GCGAGAAGAATGATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGTTAACCACCAGAAGACTCG
GGACCCGAGGACAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGATGTATTCCAAGAAAGGAG
CTGCCTGGGTGAGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAACTCGGAACACTGCTGCCAG
AATTTCCCAATGTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGATGTACAGAACACACTGTC
AGAGAATACTGGACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAGGAATGCCGCCCCACATGC
TGCCTGTGCTGGGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCTCCGGGGTGCTGATGCCCA
CTGTGCTGCAGGCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGCTAAAAGTGGCTCTCCACG
ACCTCCCAGAAAACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAACATCACTAAATCATCTCT
GCCAGGCATCTCGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGGACCTGAACAGCATCACCA
AGCAAACCCTTTACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGTTTGACCATCTCTTGGAGG
AGCAGTCTCCCATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTGCCAAGAGACAAGGGTCCT
TGAAGAAAGTGGCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCTTGCACAGCGCCCCCAGCT
TCGGGTCTTTTCACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTCAGGAGCGGGCCAATGAGC
TCATGCGAGCCATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCGCACCAACCCCTTCACCAG
TGCCATCGTTTTCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATCCTTCCCCTGAGTACACTG
GCCTCAGCACTACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGTCCCCAGCTGAGAACTCCC
AACAGCTGCCCTGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCCACAGAGAGGAACATGGAT
ACACGGGAAGCTATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCCTCCCTCATGACACAGCTA
TCTCTGGGCCACTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCCGGATGGAACCTTGTTTGA
TGAGCAGTACTCCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGTGCTACACAAGCCCGTCTG
TGCATTCTGCGAGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATGAGCACATGCAACACTTTC
CTGGCTTTGCTTACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATATTTAATATTAATAATAATA
ATTAATAATAATAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCTATTCCTAAGTGCCCATTT
TCCTAATGAACATGAGGATGGGATCAATGTGGGATGAATAAACTTTAGTTCAGAAACAGGACTTACTAAAAGTCAGTGGGACTGGGTTTC
TGTAGCCAAGCCAGACTTGACTGTTTCTGTAGAGCACTATCTCGGGCAGGCCATTCTGTGCCTTTTCCCTCTGTTCCATGACTTTGCTTT
GTGTTGGCAACCACTTCTAGTAAGCTACTGATTTTCCTGTTGACAAAATCTCTTTAGTCTTGAAGGATGGATACTGGAGACAGAATCTGG
TTTGTGTTCTTGGATGGGCACATAATTTACCAAGAGCATTCACCTTGCCATCTGTCTTGTCATTGTACTGTACAAGGAACAGCCCTCAGA
CGTGTTCTGCACATCCCTTCTTCCTGGTGGTACCATCCCTATTTCCTGGAGCACCAGGGCTAAATGGGGAGCTATCTGGAAACTCTAGAT
TTTCTGTCATACCCACATCTGTCACAGTACCTGCATTGTCTTGGAATGTAAGCACTGTCTTGAGGGAAGGAAGAGGTCTGTTCTGTATTG
CCTTAAGTTGATTGAGGTTTGTAGGAGACTGGTTCTTCTACATACAAGGATTTGTCTTAAGTTTGCACAATGGCTAGTGTCAGCAAAAGG
CAGGAGAGGGTTTTTGTTTTTTTTTTAAGTTCTATGAGAATGTGGATTTATGGCATTGAGTATCACACTCAGCTCTGCTGTGTTAACTTT
GTGAAACTGGATGGAACAAACTTTAACTTACCAAGCACCAAGTGTGAAAGTGACTTTCACGGTTCCTTCATAAAACTATAATAATATCCG
ACACTTTGATAGAAAAAAATTCAAAGCTGTGCCTTTGAGCCTATACTATACTGTGTATGTGTGGAAATAAAAATGTATTGTACTTTTGGA
GAATTTTTTGTAGGCATTTTTCTGTCAGATTTGTAGTAATTTGTGAGGTTTGTTAGAGATTAATATAGGTTTTCTTTCTGTATTATAAAA
TGCACCAAGCAATTATGGTGGACCTATTACCCTATGGGTAAGAAATAAATGGAAATATGACATCGGATGTTTCAGCAACTGTTCTGTAAA
TAAAATCTTTGATCACACCACTCAGTGTGATAATTGTGTCTACAGCTAAAATGGAAATAGTTTTATCTGTACAGTTGTGCAAGATATGAA

>In-frame_ENST00000206249_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=362_stop in transcript=3199
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000206249_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=3390nt_BP=1122nt
GAGTTGTGCCTGGAGTGATGTTTAAGCCAATGTCAGGGCAAGGCAACAGTCCCTGGCCGTCCTCCAGCACCTTTGTAATGCATATGAGCT
CGGGAGACCAGTACTTAAAGTTGGAGGCCCGGGAGCCCAGGAGCTGGCGGAGGGCGTTCGTCCTGGGACTGCACTTGCTCCCGTCGGGTC
GCCCGGCTTCACCGGACCCGCAGGCTCCCGGGGCAGGGCCGGGGCCAGAGCTCGCGTGTCGGCGGGACATGCGCTGCGTCGCCTCTAACC
TCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGA
CCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGC
AGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCT
ACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCG
GCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT
TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCT
ACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCA
AGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCA
AGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCT
GCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCAAGCCCCACTCCACTCCTG
CTACTCTGCAATGGCTGGAGGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATATGCATTACCTGGATTTCT
GCGAGAAGAATGATACCCAACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGTTAACCACCAGAAGACTCG
GGACCCGAGGACAGTCAAAGTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGATGTATTCCAAGAAAGGAG
CTGCCTGGGTGAGTGAGACGGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAACTCGGAACACTGCTGCCAG
AATTTCCCAATGTCAAAGATCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGATGTACAGAACACACTGTC
AGAGAATACTGGACACTGTAATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAGGAATGCCGCCCCACATGC
TGCCTGTGCTGGGCTCCTCCACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCTCCGGGGTGCTGATGCCCA
CTGTGCTGCAGGCATTACCTGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGCTAAAAGTGGCTCTCCACG
ACCTCCCAGAAAACTTGCGAAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAACATCACTAAATCATCTCT
GCCAGGCATCTCGAACAGTGATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGGACCTGAACAGCATCACCA
AGCAAACCCTTTACACCATGGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGTTTGACCATCTCTTGGAGG
AGCAGTCTCCCATCGAGTCCTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTGCCAAGAGACAAGGGTCCT
TGAAGAAAGTGGCCCAGCAGTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCTTGCACAGCGCCCCCAGCT
TCGGGTCTTTTCACCTAATTCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTCAGGAGCGGGCCAATGAGC
TCATGCGAGCCATGAAGGGAGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCGCACCAACCCCTTCACCAG
TGCCATCGTTTTCTCCAGCAAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATCCTTCCCCTGAGTACACTG
GCCTCAGCACTACAGGAGCAATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGTCCCCAGCTGAGAACTCCC
AACAGCTGCCCTGTATGAGGAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCCACAGAGAGGAACATGGAT
ACACGGGAAGCTATAACTATGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCCTCCCTCATGACACAGCTA
TCTCTGGGCCACTCCACTATGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCCGGATGGAACCTTGTTTGA
TGAGCAGTACTCCCAGACTGCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGTGCTACACAAGCCCGTCTG
TGCATTCTGCGAGGTACGGAAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATGAGCACATGCAACACTTTC
CTGGCTTTGCTTACATCAACGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATATTTAATATTAATAATAATA
ATTAATAATAATAATAAACCCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCTATTCCTAAGTGCCCATTT

>In-frame_ENST00000206249_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=945AA_start in transcript=362_stop in transcript=3199
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGDEEKENNRASKPHSTPA
TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGA
AWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHML
PVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLC
QASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSL
KKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPV
PSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGY
TGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSV

--------------------------------------------------------------
>In-frame_ENST00000427531_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=3884nt_BP=473nt
GCTTAAAAATAATCTCCTGCCAGCCCAGTGACAAGCCTGTCCCACCCGGGGAGAATGCCCCGGAGTGGCGTGCGGGTCAGCCAGGGTCTG
CGCCTCGCAGCCACTGTGGAAGGAGCGCGGCCGGTCCAGGACACAGGAGACCACTTTGTGACTTCAATGGCGAAGGCCAAATTCAGATAA
TCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGC
AGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACA
TAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTA
CGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCAAGCCCCACTCCACTCCTGCTACTCTGCAATGGCTGGA
GGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATATGCATTACCTGGATTTCTGCGAGAAGAATGATACCCA
ACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGTTAACCACCAGAAGACTCGGGACCCGAGGACAGTCAAA
GTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGATGTATTCCAAGAAAGGAGCTGCCTGGGTGAGTGAGAC
GGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAACTCGGAACACTGCTGCCAGAATTTCCCAATGTCAAAGA
TCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGATGTACAGAACACACTGTCAGAGAATACTGGACACTGT
AATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAGGAATGCCGCCCCACATGCTGCCTGTGCTGGGCTCCTC
CACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCTCCGGGGTGCTGATGCCCACTGTGCTGCAGGCATTACC
TGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGCTAAAAGTGGCTCTCCACGACCTCCCAGAAAACTTGCG
AAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAACATCACTAAATCATCTCTGCCAGGCATCTCGAACAGT
GATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGGACCTGAACAGCATCACCAAGCAAACCCTTTACACCAT
GGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGTTTGACCATCTCTTGGAGGAGCAGTCTCCCATCGAGTC
CTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTGCCAAGAGACAAGGGTCCTTGAAGAAAGTGGCCCAGCA
GTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCTTGCACAGCGCCCCCAGCTTCGGGTCTTTTCACCTAAT
TCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTCAGGAGCGGGCCAATGAGCTCATGCGAGCCATGAAGGG
AGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCGCACCAACCCCTTCACCAGTGCCATCGTTTTCTCCAGC
AAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATCCTTCCCCTGAGTACACTGGCCTCAGCACTACAGGAGC
AATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGTCCCCAGCTGAGAACTCCCAACAGCTGCCCTGTATGAG
GAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCCACAGAGAGGAACATGGATACACGGGAAGCTATAACTA
TGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCCTCCCTCATGACACAGCTATCTCTGGGCCACTCCACTA
TGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCCGGATGGAACCTTGTTTGATGAGCAGTACTCCCAGACT
GCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGTGCTACACAAGCCCGTCTGTGCATTCTGCGAGGTACGG
AAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATGAGCACATGCAACACTTTCCTGGCTTTGCTTACATCAA
CGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATATTTAATATTAATAATAATAATTAATAATAATAATAAAC
CCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCTATTCCTAAGTGCCCATTTTCCTAATGAACATGAGGAT
GGGATCAATGTGGGATGAATAAACTTTAGTTCAGAAACAGGACTTACTAAAAGTCAGTGGGACTGGGTTTCTGTAGCCAAGCCAGACTTG
ACTGTTTCTGTAGAGCACTATCTCGGGCAGGCCATTCTGTGCCTTTTCCCTCTGTTCCATGACTTTGCTTTGTGTTGGCAACCACTTCTA
GTAAGCTACTGATTTTCCTGTTGACAAAATCTCTTTAGTCTTGAAGGATGGATACTGGAGACAGAATCTGGTTTGTGTTCTTGGATGGGC
ACATAATTTACCAAGAGCATTCACCTTGCCATCTGTCTTGTCATTGTACTGTACAAGGAACAGCCCTCAGACGTGTTCTGCACATCCCTT
CTTCCTGGTGGTACCATCCCTATTTCCTGGAGCACCAGGGCTAAATGGGGAGCTATCTGGAAACTCTAGATTTTCTGTCATACCCACATC
TGTCACAGTACCTGCATTGTCTTGGAATGTAAGCACTGTCTTGAGGGAAGGAAGAGGTCTGTTCTGTATTGCCTTAAGTTGATTGAGGTT
TGTAGGAGACTGGTTCTTCTACATACAAGGATTTGTCTTAAGTTTGCACAATGGCTAGTGTCAGCAAAAGGCAGGAGAGGGTTTTTGTTT
TTTTTTTAAGTTCTATGAGAATGTGGATTTATGGCATTGAGTATCACACTCAGCTCTGCTGTGTTAACTTTGTGAAACTGGATGGAACAA
ACTTTAACTTACCAAGCACCAAGTGTGAAAGTGACTTTCACGGTTCCTTCATAAAACTATAATAATATCCGACACTTTGATAGAAAAAAA
TTCAAAGCTGTGCCTTTGAGCCTATACTATACTGTGTATGTGTGGAAATAAAAATGTATTGTACTTTTGGAGAATTTTTTGTAGGCATTT
TTCTGTCAGATTTGTAGTAATTTGTGAGGTTTGTTAGAGATTAATATAGGTTTTCTTTCTGTATTATAAAATGCACCAAGCAATTATGGT
GGACCTATTACCCTATGGGTAAGAAATAAATGGAAATATGACATCGGATGTTTCAGCAACTGTTCTGTAAATAAAATCTTTGATCACACC
ACTCAGTGTGATAATTGTGTCTACAGCTAAAATGGAAATAGTTTTATCTGTACAGTTGTGCAAGATATGAATGGTTTCACACTCAAATAA

>In-frame_ENST00000427531_ENST00000392842_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=781AA_start in transcript=205_stop in transcript=2550
MASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGD
EEKENNRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAV
KESSQYYDVMYSKKGAAWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEV
QSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSR
RFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTM
VDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVR
EEIILTEAAAPTPSPVPSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSS
VTHRIPVYPHREEHGYTGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPR

--------------------------------------------------------------
>In-frame_ENST00000427531_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(transcript)=2741nt_BP=473nt
GCTTAAAAATAATCTCCTGCCAGCCCAGTGACAAGCCTGTCCCACCCGGGGAGAATGCCCCGGAGTGGCGTGCGGGTCAGCCAGGGTCTG
CGCCTCGCAGCCACTGTGGAAGGAGCGCGGCCGGTCCAGGACACAGGAGACCACTTTGTGACTTCAATGGCGAAGGCCAAATTCAGATAA
TCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGC
AGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACA
TAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTA
CGAAGTGGGAATGATGAAAGGTGATGAGGAAAAAGAAAATAATAGAGCATCCAAGCCCCACTCCACTCCTGCTACTCTGCAATGGCTGGA
GGAGAACTATGAGATTGCAGAGGGGGTCTGCATCCCTCGCAGTGCCCTCTATATGCATTACCTGGATTTCTGCGAGAAGAATGATACCCA
ACCTGTCAATGCTGCCAGCTTTGGAAAGATCATAAGGCAGCAGTTTCCTCAGTTAACCACCAGAAGACTCGGGACCCGAGGACAGTCAAA
GTACCATTACTATGGCATTGCAGTGAAAGAAAGCTCCCAATATTATGATGTGATGTATTCCAAGAAAGGAGCTGCCTGGGTGAGTGAGAC
GGGCAAGAAAGAAGTGAGCAAACAGACAGTGGCATATTCACCCCGGTCCAAACTCGGAACACTGCTGCCAGAATTTCCCAATGTCAAAGA
TCTAAATCTGCCAGCCAGCCTGCCTGAGGAGAAGGTTTCTACCTTTATTATGATGTACAGAACACACTGTCAGAGAATACTGGACACTGT
AATAAGAGCCAACTTTGATGAGGTTCAAAGTTTCCTTCTGCACTTTTGGCAAGGAATGCCGCCCCACATGCTGCCTGTGCTGGGCTCCTC
CACGGTGGTGAACATTGTCGGCGTGTGTGACTCCATCCTCTACAAAGCTATCTCCGGGGTGCTGATGCCCACTGTGCTGCAGGCATTACC
TGACAGCTTAACTCAGGTGATTCGAAAGTTTGCCAAGCAACTGGATGAGTGGCTAAAAGTGGCTCTCCACGACCTCCCAGAAAACTTGCG
AAACATCAAGTTCGAATTGTCGAGAAGGTTCTCCCAAATTCTGAGACGGCAAACATCACTAAATCATCTCTGCCAGGCATCTCGAACAGT
GATCCACAGTGCAGACATCACGTTCCAAATGCTGGAAGACTGGAGGAACGTGGACCTGAACAGCATCACCAAGCAAACCCTTTACACCAT
GGAAGACTCTCGCGATGAGCACCGGAAACTCATCACCCAATTATATCAGGAGTTTGACCATCTCTTGGAGGAGCAGTCTCCCATCGAGTC
CTACATTGAGTGGCTGGATACCATGGTTGACCGCTGTGTTGTGAAGGTGGCTGCCAAGAGACAAGGGTCCTTGAAGAAAGTGGCCCAGCA
GTTCCTCTTGATGTGGTCCTGTTTCGGCACAAGGGTGATCCGGGACATGACCTTGCACAGCGCCCCCAGCTTCGGGTCTTTTCACCTAAT
TCACTTAATGTTTGATGACTACGTGCTCTACCTGTTAGAATCTCTGCACTGTCAGGAGCGGGCCAATGAGCTCATGCGAGCCATGAAGGG
AGAAGGAAGCACTGCAGAAGTCCGAGAAGAGATCATCTTGACAGAGGCTGCCGCACCAACCCCTTCACCAGTGCCATCGTTTTCTCCAGC
AAAATCTGCCACATCTGTGGAAGTGCCACCTCCCTCTTCCCCTGTTAGCAATCCTTCCCCTGAGTACACTGGCCTCAGCACTACAGGAGC
AATGCAGTCTTACACGTGGTCTCTAACATACACAGTGACGACGGCTGCTGGGTCCCCAGCTGAGAACTCCCAACAGCTGCCCTGTATGAG
GAACACTCATGTGCCTTCTTCCTCCGTCACACACAGGATACCAGTTTATCCCCACAGAGAGGAACATGGATACACGGGAAGCTATAACTA
TGGGAGCTATGGCAACCAGCATCCTCACCCCATGCAGAGCCAGTATCCGGCCCTCCCTCATGACACAGCTATCTCTGGGCCACTCCACTA
TGCCCCTTACCACAGGAGCTCTGCACAGTACCCTTTTAATAGCCCCACTTCCCGGATGGAACCTTGTTTGATGAGCAGTACTCCCAGACT
GCATCCTACCCCAGTCACTCCCCGCTGGCCAGAGGTGCCCTCAGCCAACACGTGCTACACAAGCCCGTCTGTGCATTCTGCGAGGTACGG
AAACTCTAGTGACATGTATACACCTCTGACAACGCGCAGGAATTCTGAATATGAGCACATGCAACACTTTCCTGGCTTTGCTTACATCAA
CGGAGAGGCCTCTACAGGATGGGCTAAATGACTGCTATCATAGGCATCCATATTTAATATTAATAATAATAATTAATAATAATAATAAAC
CCAACACCCATCCCCCAGAAGACTTTATCTCTATACATTGTAACTCATGGGCTATTCCTAAGTGCCCATTTTCCTAATGAACATGAGGAT

>In-frame_ENST00000427531_ENST00000357881_M69296_ESR1_chr6_152201906_+_RFX4_chr12_107033109_length(amino acids)=781AA_start in transcript=205_stop in transcript=2550
MASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGD
EEKENNRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAV
KESSQYYDVMYSKKGAAWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEV
QSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSR
RFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTM
VDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVR
EEIILTEAAAPTPSPVPSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSS
VTHRIPVYPHREEHGYTGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ESR1-RFX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneESR1chr6:152201906chr12:107033109ENST00000206249+3835_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201906chr12:107033109ENST00000338799+4935_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201906chr12:107033109ENST00000440973+51035_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201906chr12:107033109ENST00000443427+4935_174253.33333333333334596.0DDX5%3B self-association
HgeneESR1chr6:152201906chr12:107033109ENST00000456483+4835_174253.33333333333334484.0DDX5%3B self-association


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneESR1chr6:152201906chr12:107033109ENST00000206249+38262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr12:107033109ENST00000338799+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr12:107033109ENST00000440973+510262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr12:107033109ENST00000443427+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr12:107033109ENST00000456483+48262_595253.33333333333334484.0AKAP13


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ESR1-RFX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneESR1P03372DB00286Conjugated estrogensAgonistSmall moleculeApproved
HgeneESR1P03372DB00286Conjugated estrogensAgonistSmall moleculeApproved
HgeneESR1P03372DB00286Conjugated estrogensAgonistSmall moleculeApproved
HgeneESR1P03372DB00304DesogestrelAgonistSmall moleculeApproved
HgeneESR1P03372DB00304DesogestrelAgonistSmall moleculeApproved
HgeneESR1P03372DB00304DesogestrelAgonistSmall moleculeApproved
HgeneESR1P03372DB00648MitotaneSmall moleculeApproved
HgeneESR1P03372DB00648MitotaneSmall moleculeApproved
HgeneESR1P03372DB00648MitotaneSmall moleculeApproved
HgeneESR1P03372DB00655EstroneAgonistSmall moleculeApproved
HgeneESR1P03372DB00655EstroneAgonistSmall moleculeApproved
HgeneESR1P03372DB00655EstroneAgonistSmall moleculeApproved
HgeneESR1P03372DB00675TamoxifenAgonist|AntagonistSmall moleculeApproved
HgeneESR1P03372DB00675TamoxifenAgonist|AntagonistSmall moleculeApproved
HgeneESR1P03372DB00675TamoxifenAgonist|AntagonistSmall moleculeApproved
HgeneESR1P03372DB00823Ethynodiol diacetateAgonistSmall moleculeApproved
HgeneESR1P03372DB00823Ethynodiol diacetateAgonistSmall moleculeApproved
HgeneESR1P03372DB00823Ethynodiol diacetateAgonistSmall moleculeApproved
HgeneESR1P03372DB00841DobutamineSmall moleculeApproved
HgeneESR1P03372DB00841DobutamineSmall moleculeApproved
HgeneESR1P03372DB00841DobutamineSmall moleculeApproved
HgeneESR1P03372DB00977EthinylestradiolAgonistSmall moleculeApproved
HgeneESR1P03372DB00977EthinylestradiolAgonistSmall moleculeApproved
HgeneESR1P03372DB00977EthinylestradiolAgonistSmall moleculeApproved
HgeneESR1P03372DB01357MestranolAgonistSmall moleculeApproved
HgeneESR1P03372DB01357MestranolAgonistSmall moleculeApproved
HgeneESR1P03372DB01357MestranolAgonistSmall moleculeApproved
HgeneESR1P03372DB01406DanazolAgonistSmall moleculeApproved
HgeneESR1P03372DB01406DanazolAgonistSmall moleculeApproved
HgeneESR1P03372DB01406DanazolAgonistSmall moleculeApproved
HgeneESR1P03372DB04574Estrone sulfateAgonistSmall moleculeApproved
HgeneESR1P03372DB04574Estrone sulfateAgonistSmall moleculeApproved
HgeneESR1P03372DB04574Estrone sulfateAgonistSmall moleculeApproved
HgeneESR1P03372DB04575QuinestrolAgonist|ModulatorSmall moleculeApproved
HgeneESR1P03372DB04575QuinestrolAgonist|ModulatorSmall moleculeApproved
HgeneESR1P03372DB04575QuinestrolAgonist|ModulatorSmall moleculeApproved
HgeneESR1P03372DB06710MethyltestosteroneSmall moleculeApproved
HgeneESR1P03372DB06710MethyltestosteroneSmall moleculeApproved
HgeneESR1P03372DB06710MethyltestosteroneSmall moleculeApproved
HgeneESR1P03372DB09086EugenolSmall moleculeApproved
HgeneESR1P03372DB09086EugenolSmall moleculeApproved
HgeneESR1P03372DB09086EugenolSmall moleculeApproved
HgeneESR1P03372DB09317Synthetic Conjugated Estrogens, ALigandSmall moleculeApproved
HgeneESR1P03372DB09317Synthetic Conjugated Estrogens, ALigandSmall moleculeApproved
HgeneESR1P03372DB09317Synthetic Conjugated Estrogens, ALigandSmall moleculeApproved
HgeneESR1P03372DB09318Synthetic Conjugated Estrogens, BLigandSmall moleculeApproved
HgeneESR1P03372DB09318Synthetic Conjugated Estrogens, BLigandSmall moleculeApproved
HgeneESR1P03372DB09318Synthetic Conjugated Estrogens, BLigandSmall moleculeApproved
HgeneESR1P03372DB09369Polyestradiol phosphateAgonistSmall moleculeApproved
HgeneESR1P03372DB09369Polyestradiol phosphateAgonistSmall moleculeApproved
HgeneESR1P03372DB09369Polyestradiol phosphateAgonistSmall moleculeApproved
HgeneESR1P03372DB09371NorethynodrelSmall moleculeApproved
HgeneESR1P03372DB09371NorethynodrelSmall moleculeApproved
HgeneESR1P03372DB09371NorethynodrelSmall moleculeApproved
HgeneESR1P03372DB11219EnzacameneSmall moleculeApproved
HgeneESR1P03372DB11219EnzacameneSmall moleculeApproved
HgeneESR1P03372DB11219EnzacameneSmall moleculeApproved
HgeneESR1P03372DB11619GestrinoneAgonist|AntagonistSmall moleculeApproved
HgeneESR1P03372DB11619GestrinoneAgonist|AntagonistSmall moleculeApproved
HgeneESR1P03372DB11619GestrinoneAgonist|AntagonistSmall moleculeApproved
HgeneESR1P03372DB13943Testosterone cypionateSmall moleculeApproved
HgeneESR1P03372DB13943Testosterone cypionateSmall moleculeApproved
HgeneESR1P03372DB13943Testosterone cypionateSmall moleculeApproved
HgeneESR1P03372DB13944Testosterone enanthateSmall moleculeApproved
HgeneESR1P03372DB13944Testosterone enanthateSmall moleculeApproved
HgeneESR1P03372DB13944Testosterone enanthateSmall moleculeApproved
HgeneESR1P03372DB15690Fluoroestradiol F-18BinderSmall moleculeApproved
HgeneESR1P03372DB15690Fluoroestradiol F-18BinderSmall moleculeApproved
HgeneESR1P03372DB15690Fluoroestradiol F-18BinderSmall moleculeApproved
HgeneESR1P03372DB14548Zinc sulfate, unspecified formBinderSmall moleculeApproved|Experimental
HgeneESR1P03372DB14548Zinc sulfate, unspecified formBinderSmall moleculeApproved|Experimental
HgeneESR1P03372DB14548Zinc sulfate, unspecified formBinderSmall moleculeApproved|Experimental
HgeneESR1P03372DB01185FluoxymesteroneAntagonistSmall moleculeApproved|Illicit
HgeneESR1P03372DB01185FluoxymesteroneAntagonistSmall moleculeApproved|Illicit
HgeneESR1P03372DB01185FluoxymesteroneAntagonistSmall moleculeApproved|Illicit
HgeneESR1P03372DB00255DiethylstilbestrolAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00255DiethylstilbestrolAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00255DiethylstilbestrolAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00367LevonorgestrelOther/unknownSmall moleculeApproved|Investigational
HgeneESR1P03372DB00367LevonorgestrelOther/unknownSmall moleculeApproved|Investigational
HgeneESR1P03372DB00367LevonorgestrelOther/unknownSmall moleculeApproved|Investigational
HgeneESR1P03372DB00481RaloxifeneAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00481RaloxifeneAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00481RaloxifeneAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00539ToremifeneModulatorSmall moleculeApproved|Investigational
HgeneESR1P03372DB00539ToremifeneModulatorSmall moleculeApproved|Investigational
HgeneESR1P03372DB00539ToremifeneModulatorSmall moleculeApproved|Investigational
HgeneESR1P03372DB00603Medroxyprogesterone acetateAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00603Medroxyprogesterone acetateAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00603Medroxyprogesterone acetateAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00624TestosteroneInhibitorSmall moleculeApproved|Investigational
HgeneESR1P03372DB00624TestosteroneInhibitorSmall moleculeApproved|Investigational
HgeneESR1P03372DB00624TestosteroneInhibitorSmall moleculeApproved|Investigational
HgeneESR1P03372DB00882ClomifeneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00882ClomifeneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00882ClomifeneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00890DienestrolAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00890DienestrolAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00890DienestrolAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00947FulvestrantAntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00947FulvestrantAntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00947FulvestrantAntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00957NorgestimateAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00957NorgestimateAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB00957NorgestimateAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB01196EstramustineAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB01196EstramustineAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB01196EstramustineAgonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB01428OxybenzoneSmall moleculeApproved|Investigational
HgeneESR1P03372DB01428OxybenzoneSmall moleculeApproved|Investigational
HgeneESR1P03372DB01428OxybenzoneSmall moleculeApproved|Investigational
HgeneESR1P03372DB01593ZincCofactorSmall moleculeApproved|Investigational
HgeneESR1P03372DB01593ZincCofactorSmall moleculeApproved|Investigational
HgeneESR1P03372DB01593ZincCofactorSmall moleculeApproved|Investigational
HgeneESR1P03372DB04930PermethrinSmall moleculeApproved|Investigational
HgeneESR1P03372DB04930PermethrinSmall moleculeApproved|Investigational
HgeneESR1P03372DB04930PermethrinSmall moleculeApproved|Investigational
HgeneESR1P03372DB04938OspemifeneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB04938OspemifeneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB04938OspemifeneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB06202LasofoxifeneAgonist|Antagonist|Negative modulatorSmall moleculeApproved|Investigational
HgeneESR1P03372DB06202LasofoxifeneAgonist|Antagonist|Negative modulatorSmall moleculeApproved|Investigational
HgeneESR1P03372DB06202LasofoxifeneAgonist|Antagonist|Negative modulatorSmall moleculeApproved|Investigational
HgeneESR1P03372DB06249ArzoxifeneSmall moleculeApproved|Investigational
HgeneESR1P03372DB06249ArzoxifeneSmall moleculeApproved|Investigational
HgeneESR1P03372DB06249ArzoxifeneSmall moleculeApproved|Investigational
HgeneESR1P03372DB06401BazedoxifeneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB06401BazedoxifeneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB06401BazedoxifeneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB09070TiboloneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB09070TiboloneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB09070TiboloneAgonist|AntagonistSmall moleculeApproved|Investigational
HgeneESR1P03372DB09535OctocryleneSmall moleculeApproved|Investigational
HgeneESR1P03372DB09535OctocryleneSmall moleculeApproved|Investigational
HgeneESR1P03372DB09535OctocryleneSmall moleculeApproved|Investigational
HgeneESR1P03372DB11064HomosalateSmall moleculeApproved|Investigational
HgeneESR1P03372DB11064HomosalateSmall moleculeApproved|Investigational
HgeneESR1P03372DB11064HomosalateSmall moleculeApproved|Investigational
HgeneESR1P03372DB13946Testosterone undecanoateSmall moleculeApproved|Investigational
HgeneESR1P03372DB13946Testosterone undecanoateSmall moleculeApproved|Investigational
HgeneESR1P03372DB13946Testosterone undecanoateSmall moleculeApproved|Investigational
HgeneESR1P03372DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneESR1P03372DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneESR1P03372DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneESR1P03372DB14533Zinc chlorideBinderSmall moleculeApproved|Investigational
HgeneESR1P03372DB14533Zinc chlorideBinderSmall moleculeApproved|Investigational
HgeneESR1P03372DB14533Zinc chlorideBinderSmall moleculeApproved|Investigational
HgeneESR1P03372DB01708PrasteroneBinderSmall moleculeApproved|Investigational|Nutraceutical
HgeneESR1P03372DB01708PrasteroneBinderSmall moleculeApproved|Investigational|Nutraceutical
HgeneESR1P03372DB01708PrasteroneBinderSmall moleculeApproved|Investigational|Nutraceutical
HgeneESR1P03372DB00783EstradiolAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB00783EstradiolAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB00783EstradiolAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB04573EstriolAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB04573EstriolAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB04573EstriolAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13952Estradiol acetateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13952Estradiol acetateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13952Estradiol acetateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13953Estradiol benzoateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13953Estradiol benzoateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13953Estradiol benzoateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13954Estradiol cypionateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13954Estradiol cypionateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13954Estradiol cypionateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13955Estradiol dienanthateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13955Estradiol dienanthateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13955Estradiol dienanthateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13956Estradiol valerateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13956Estradiol valerateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB13956Estradiol valerateAgonistSmall moleculeApproved|Investigational|Vet_approved
HgeneESR1P03372DB01108TrilostaneAllosteric modulatorSmall moleculeApproved|Investigational|Vet_approved|Withdrawn
HgeneESR1P03372DB01108TrilostaneAllosteric modulatorSmall moleculeApproved|Investigational|Vet_approved|Withdrawn
HgeneESR1P03372DB01108TrilostaneAllosteric modulatorSmall moleculeApproved|Investigational|Vet_approved|Withdrawn
HgeneESR1P03372DB01065MelatoninAntagonistSmall moleculeApproved|Nutraceutical|Vet_approved
HgeneESR1P03372DB01065MelatoninAntagonistSmall moleculeApproved|Nutraceutical|Vet_approved
HgeneESR1P03372DB01065MelatoninAntagonistSmall moleculeApproved|Nutraceutical|Vet_approved
HgeneESR1P03372DB00396ProgesteroneAgonist|Downregulator|InhibitorSmall moleculeApproved|Vet_approved
HgeneESR1P03372DB00396ProgesteroneAgonist|Downregulator|InhibitorSmall moleculeApproved|Vet_approved
HgeneESR1P03372DB00396ProgesteroneAgonist|Downregulator|InhibitorSmall moleculeApproved|Vet_approved
HgeneESR1P03372DB01183NaloxoneAntagonist|Other/unknownSmall moleculeApproved|Vet_approved
HgeneESR1P03372DB01183NaloxoneAntagonist|Other/unknownSmall moleculeApproved|Vet_approved
HgeneESR1P03372DB01183NaloxoneAntagonist|Other/unknownSmall moleculeApproved|Vet_approved
HgeneESR1P03372DB00431LindaneSmall moleculeApproved|Withdrawn
HgeneESR1P03372DB00431LindaneSmall moleculeApproved|Withdrawn
HgeneESR1P03372DB00431LindaneSmall moleculeApproved|Withdrawn
HgeneESR1P03372DB00756HexachloropheneSmall moleculeApproved|Withdrawn
HgeneESR1P03372DB00756HexachloropheneSmall moleculeApproved|Withdrawn
HgeneESR1P03372DB00756HexachloropheneSmall moleculeApproved|Withdrawn
HgeneESR1P03372DB04824PhenolphthaleinAgonistSmall moleculeApproved|Withdrawn
HgeneESR1P03372DB04824PhenolphthaleinAgonistSmall moleculeApproved|Withdrawn
HgeneESR1P03372DB04824PhenolphthaleinAgonistSmall moleculeApproved|Withdrawn
HgeneESR1P03372DB11478ZeranolSmall moleculeExperimental|Vet_approved
HgeneESR1P03372DB11478ZeranolSmall moleculeExperimental|Vet_approved
HgeneESR1P03372DB11478ZeranolSmall moleculeExperimental|Vet_approved
HgeneESR1P03372DB11541RactopamineSmall moleculeVet_approved
HgeneESR1P03372DB11541RactopamineSmall moleculeVet_approved
HgeneESR1P03372DB11541RactopamineSmall moleculeVet_approved

Top

Related Diseases for ESR1-RFX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneESR1C0006142Malignant neoplasm of breast14CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneESR1C0678222Breast Carcinoma14CGI;CTD_human
HgeneESR1C1257931Mammary Neoplasms, Human14CTD_human
HgeneESR1C1458155Mammary Neoplasms14CTD_human
HgeneESR1C4704874Mammary Carcinoma, Human14CTD_human
HgeneESR1C0005586Bipolar Disorder5PSYGENET
HgeneESR1C0011570Mental Depression5PSYGENET
HgeneESR1C0011581Depressive disorder5PSYGENET
HgeneESR1C0036341Schizophrenia5PSYGENET
HgeneESR1C0525045Mood Disorders4PSYGENET
HgeneESR1C3809250ESTROGEN RESISTANCE3GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneESR1C0001418Adenocarcinoma2CTD_human
HgeneESR1C0007097Carcinoma2CTD_human
HgeneESR1C0007621Neoplastic Cell Transformation2CTD_human
HgeneESR1C0010054Coronary Arteriosclerosis2CTD_human
HgeneESR1C0021364Male infertility2CTD_human
HgeneESR1C0024121Lung Neoplasms2CTD_human
HgeneESR1C0024667Animal Mammary Neoplasms2CTD_human
HgeneESR1C0025500Mesothelioma2CTD_human
HgeneESR1C0027626Neoplasm Invasiveness2CTD_human
HgeneESR1C0033578Prostatic Neoplasms2CTD_human
HgeneESR1C0205641Adenocarcinoma, Basal Cell2CTD_human
HgeneESR1C0205642Adenocarcinoma, Oxyphilic2CTD_human
HgeneESR1C0205643Carcinoma, Cribriform2CTD_human
HgeneESR1C0205644Carcinoma, Granular Cell2CTD_human
HgeneESR1C0205645Adenocarcinoma, Tubular2CTD_human
HgeneESR1C0205696Anaplastic carcinoma2CTD_human
HgeneESR1C0205697Carcinoma, Spindle-Cell2CTD_human
HgeneESR1C0205698Undifferentiated carcinoma2CTD_human
HgeneESR1C0205699Carcinomatosis2CTD_human
HgeneESR1C0242379Malignant neoplasm of lung2CTD_human
HgeneESR1C0376358Malignant neoplasm of prostate2CTD_human
HgeneESR1C0848676Subfertility, Male2CTD_human
HgeneESR1C0917731Male sterility2CTD_human
HgeneESR1C1257925Mammary Carcinoma, Animal2CTD_human
HgeneESR1C1956346Coronary Artery Disease2CTD_human
HgeneESR1C2239176Liver carcinoma2CTD_human
HgeneESR1C0002395Alzheimer's Disease1CTD_human
HgeneESR1C0004114Astrocytoma1CTD_human
HgeneESR1C0004153Atherosclerosis1CTD_human
HgeneESR1C0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneESR1C0005695Bladder Neoplasm1CTD_human
HgeneESR1C0005940Bone Diseases1CTD_human
HgeneESR1C0005944Metabolic Bone Disorder1CTD_human
HgeneESR1C0007852Cervical Migraine Syndrome1CTD_human
HgeneESR1C0011265Presenile dementia1CTD_human
HgeneESR1C0014170Endometrial Neoplasms1CTD_human
HgeneESR1C0017658Glomerulonephritis1CTD_human
HgeneESR1C0018984Hemicrania migraine1CTD_human
HgeneESR1C0021361Female infertility1CTD_human
HgeneESR1C0023267Fibroid Tumor1CTD_human
HgeneESR1C0023418leukemia1CTD_human
HgeneESR1C0023903Liver neoplasms1CTD_human
HgeneESR1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneESR1C0024809Marijuana Abuse1PSYGENET
HgeneESR1C0026858Musculoskeletal Pain1CTD_human
HgeneESR1C0027051Myocardial Infarction1CTD_human
HgeneESR1C0027627Neoplasm Metastasis1CTD_human
HgeneESR1C0027643Neoplasm Recurrence, Local1CTD_human
HgeneESR1C0027819Neuroblastoma1CTD_human
HgeneESR1C0028754Obesity1CTD_human
HgeneESR1C0028960Oligospermia1CTD_human
HgeneESR1C0029453Osteopenia1CTD_human
HgeneESR1C0033937Psychoses, Drug1CTD_human
HgeneESR1C0033941Psychoses, Substance-Induced1CTD_human
HgeneESR1C0036939Shared Paranoid Disorder1PSYGENET
HgeneESR1C0038279Sterility, Postpartum1CTD_human
HgeneESR1C0042133Uterine Fibroids1CTD_human
HgeneESR1C0149931Migraine Disorders1CTD_human
HgeneESR1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneESR1C0235874Disease Exacerbation1CTD_human
HgeneESR1C0270858Abdominal Migraine1CTD_human
HgeneESR1C0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneESR1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneESR1C0280785Diffuse Astrocytoma1CTD_human
HgeneESR1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
HgeneESR1C0334579Anaplastic astrocytoma1CTD_human
HgeneESR1C0334580Protoplasmic astrocytoma1CTD_human
HgeneESR1C0334581Gemistocytic astrocytoma1CTD_human
HgeneESR1C0334582Fibrillary Astrocytoma1CTD_human
HgeneESR1C0334583Pilocytic Astrocytoma1CTD_human
HgeneESR1C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneESR1C0338489Status Migrainosus1CTD_human
HgeneESR1C0341869Subfertility, Female1CTD_human
HgeneESR1C0345904Malignant neoplasm of liver1CTD_human
HgeneESR1C0476089Endometrial Carcinoma1CGI;CTD_human
HgeneESR1C0494463Alzheimer Disease, Late Onset1CTD_human
HgeneESR1C0521664Acute Confusional Migraine1CTD_human
HgeneESR1C0546126Acute Confusional Senile Dementia1CTD_human
HgeneESR1C0547065Mixed oligoastrocytoma1CTD_human
HgeneESR1C0700438Sick Headaches1CTD_human
HgeneESR1C0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneESR1C0750901Alzheimer Disease, Early Onset1CTD_human
HgeneESR1C0750935Cerebral Astrocytoma1CTD_human
HgeneESR1C0750936Intracranial Astrocytoma1CTD_human
HgeneESR1C0917730Female sterility1CTD_human
HgeneESR1C1563937Atherogenesis1CTD_human
HgeneESR1C1704230Grade I Astrocytoma1CTD_human
HgeneESR1C1704377Bright Disease1CTD_human
HgeneESR1C1720887Female Urogenital Diseases1CTD_human
HgeneESR1C1800706Idiopathic Pulmonary Fibrosis1CTD_human
HgeneESR1C4721508Hamman-Rich Disease1CTD_human
HgeneESR1C4721509Usual Interstitial Pneumonia1CTD_human
HgeneESR1C4721952Familial Idiopathic Pulmonary Fibrosis1CTD_human
TgeneRFX4C0005586Bipolar Disorder2PSYGENET
TgeneRFX4C0001973Alcoholic Intoxication, Chronic1PSYGENET