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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ESYT2-VIPR2 (FusionGDB2 ID:27574)

Fusion Gene Summary for ESYT2-VIPR2

check button Fusion gene summary
Fusion gene informationFusion gene name: ESYT2-VIPR2
Fusion gene ID: 27574
HgeneTgene
Gene symbol

ESYT2

VIPR2

Gene ID

57488

7434

Gene nameextended synaptotagmin 2vasoactive intestinal peptide receptor 2
SynonymsCHR2SYT|E-Syt2|FAM62BC16DUPq36.3|DUP7q36.3|PACAP-R-3|PACAP-R3|VIP-R-2|VPAC2|VPAC2R|VPCAP2R
Cytomap

7q36.3

7q36.3

Type of geneprotein-codingprotein-coding
Descriptionextended synaptotagmin-2chr2 synaptotagminextended synaptotagmin like protein 2extended synaptotagmin protein 2family with sequence similarity 62 (C2 domain containing), member Bvasoactive intestinal polypeptide receptor 2PACAP type III receptorVIP and PACAP receptor 2helodermin-preferring VIP receptorpituitary adenylate cyclase-activating polypeptide type III receptor
Modification date2020031320200313
UniProtAcc

A0FGR8

.
Ensembl transtripts involved in fusion geneENST00000251527, ENST00000497111, 
ENST00000435514, 		ENST00000262178, 
ENST00000377633, ENST00000402066, 
ENST00000421760, 
Fusion gene scores* DoF score13 X 11 X 10=14305 X 5 X 5=125
# samples 167
** MAII scorelog2(16/1430*10)=-3.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/125*10)=-0.836501267717121
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESYT2 [Title/Abstract] AND VIPR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointESYT2(158580695)-VIPR2(158851269), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ESYT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VIPR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-GL-8500-01AESYT2chr7

158580695

-VIPR2chr7

158851269

-
ChimerDB4KIRPTCGA-GL-8500ESYT2chr7

158580694

-VIPR2chr7

158851269

-
ChimerDB4KIRPTCGA-GL-8500ESYT2chr7

158580695

-VIPR2chr7

158851269

-
ChimerDB4LUSCTCGA-33-A4WN-01AESYT2chr7

158580694

-VIPR2chr7

158852276

+


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Fusion Gene ORF analysis for ESYT2-VIPR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000251527ENST00000262178ESYT2chr7

158580695

-VIPR2chr7

158851269

-
In-frameENST00000251527ENST00000377633ESYT2chr7

158580695

-VIPR2chr7

158851269

-
In-frameENST00000251527ENST00000402066ESYT2chr7

158580695

-VIPR2chr7

158851269

-
5CDS-intronENST00000251527ENST00000421760ESYT2chr7

158580695

-VIPR2chr7

158851269

-
intron-3CDSENST00000497111ENST00000262178ESYT2chr7

158580695

-VIPR2chr7

158851269

-
intron-3CDSENST00000497111ENST00000377633ESYT2chr7

158580695

-VIPR2chr7

158851269

-
intron-3CDSENST00000497111ENST00000402066ESYT2chr7

158580695

-VIPR2chr7

158851269

-
intron-intronENST00000497111ENST00000421760ESYT2chr7

158580695

-VIPR2chr7

158851269

-
intron-3CDSENST00000435514ENST00000262178ESYT2chr7

158580695

-VIPR2chr7

158851269

-
intron-3CDSENST00000435514ENST00000377633ESYT2chr7

158580695

-VIPR2chr7

158851269

-
intron-3CDSENST00000435514ENST00000402066ESYT2chr7

158580695

-VIPR2chr7

158851269

-
intron-intronENST00000435514ENST00000421760ESYT2chr7

158580695

-VIPR2chr7

158851269

-
In-frameENST00000251527ENST00000262178ESYT2chr7

158580694

-VIPR2chr7

158851269

-
In-frameENST00000251527ENST00000377633ESYT2chr7

158580694

-VIPR2chr7

158851269

-
In-frameENST00000251527ENST00000402066ESYT2chr7

158580694

-VIPR2chr7

158851269

-
5CDS-intronENST00000251527ENST00000421760ESYT2chr7

158580694

-VIPR2chr7

158851269

-
intron-3CDSENST00000497111ENST00000262178ESYT2chr7

158580694

-VIPR2chr7

158851269

-
intron-3CDSENST00000497111ENST00000377633ESYT2chr7

158580694

-VIPR2chr7

158851269

-
intron-3CDSENST00000497111ENST00000402066ESYT2chr7

158580694

-VIPR2chr7

158851269

-
intron-intronENST00000497111ENST00000421760ESYT2chr7

158580694

-VIPR2chr7

158851269

-
intron-3CDSENST00000435514ENST00000262178ESYT2chr7

158580694

-VIPR2chr7

158851269

-
intron-3CDSENST00000435514ENST00000377633ESYT2chr7

158580694

-VIPR2chr7

158851269

-
intron-3CDSENST00000435514ENST00000402066ESYT2chr7

158580694

-VIPR2chr7

158851269

-
intron-intronENST00000435514ENST00000421760ESYT2chr7

158580694

-VIPR2chr7

158851269

-
5CDS-intronENST00000251527ENST00000262178ESYT2chr7

158580694

-VIPR2chr7

158852276

+
5CDS-intronENST00000251527ENST00000377633ESYT2chr7

158580694

-VIPR2chr7

158852276

+
5CDS-intronENST00000251527ENST00000402066ESYT2chr7

158580694

-VIPR2chr7

158852276

+
5CDS-intronENST00000251527ENST00000421760ESYT2chr7

158580694

-VIPR2chr7

158852276

+
intron-intronENST00000497111ENST00000262178ESYT2chr7

158580694

-VIPR2chr7

158852276

+
intron-intronENST00000497111ENST00000377633ESYT2chr7

158580694

-VIPR2chr7

158852276

+
intron-intronENST00000497111ENST00000402066ESYT2chr7

158580694

-VIPR2chr7

158852276

+
intron-intronENST00000497111ENST00000421760ESYT2chr7

158580694

-VIPR2chr7

158852276

+
intron-intronENST00000435514ENST00000262178ESYT2chr7

158580694

-VIPR2chr7

158852276

+
intron-intronENST00000435514ENST00000377633ESYT2chr7

158580694

-VIPR2chr7

158852276

+
intron-intronENST00000435514ENST00000402066ESYT2chr7

158580694

-VIPR2chr7

158852276

+
intron-intronENST00000435514ENST00000421760ESYT2chr7

158580694

-VIPR2chr7

158852276

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000251527ESYT2chr7158580695-ENST00000262178VIPR2chr7158851269-4358957661916616
ENST00000251527ESYT2chr7158580695-ENST00000377633VIPR2chr7158851269-2078957661916616
ENST00000251527ESYT2chr7158580695-ENST00000402066VIPR2chr7158851269-2015957661916616
ENST00000251527ESYT2chr7158580694-ENST00000262178VIPR2chr7158851269-4358957661916616
ENST00000251527ESYT2chr7158580694-ENST00000377633VIPR2chr7158851269-2078957661916616
ENST00000251527ESYT2chr7158580694-ENST00000402066VIPR2chr7158851269-2015957661916616

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000251527ENST00000262178ESYT2chr7158580695-VIPR2chr7158851269-0.0089784390.9910216
ENST00000251527ENST00000377633ESYT2chr7158580695-VIPR2chr7158851269-0.0137587920.9862412
ENST00000251527ENST00000402066ESYT2chr7158580695-VIPR2chr7158851269-0.0157127340.98428726
ENST00000251527ENST00000262178ESYT2chr7158580694-VIPR2chr7158851269-0.0089784390.9910216
ENST00000251527ENST00000377633ESYT2chr7158580694-VIPR2chr7158851269-0.0137587920.9862412
ENST00000251527ENST00000402066ESYT2chr7158580694-VIPR2chr7158851269-0.0157127340.98428726

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Fusion Genomic Features for ESYT2-VIPR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ESYT2-VIPR2


check button Go to

FGviewer for the breakpoints of chr7:158580695-chr7:158851269

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESYT2

A0FGR8

.
FUNCTION: Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:27044890). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:24847877, ECO:0000269|PubMed:27044890}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-622125_127297.0894.0Topological domainLumenal
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-6221_103297.0894.0Topological domainCytoplasmic
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-622125_127297.0894.0Topological domainLumenal
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-6221_103297.0894.0Topological domainCytoplasmic
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-622104_124297.0894.0TransmembraneHelical
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-622128_148297.0894.0TransmembraneHelical
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-622104_124297.0894.0TransmembraneHelical
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-622128_148297.0894.0TransmembraneHelical
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313152_158119.0439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313179_203119.0439.0Topological domainExtracellular
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313228_240119.0439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313263_279119.0439.0Topological domainExtracellular
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313304_328119.0439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313349_360119.0439.0Topological domainExtracellular
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313381_438119.0439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313152_158119.0439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313179_203119.0439.0Topological domainExtracellular
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313228_240119.0439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313263_279119.0439.0Topological domainExtracellular
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313304_328119.0439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313349_360119.0439.0Topological domainExtracellular
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313381_438119.0439.0Topological domainCytoplasmic
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313127_151119.0439.0TransmembraneHelical%3B Name%3D1
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313159_178119.0439.0TransmembraneHelical%3B Name%3D2
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313204_227119.0439.0TransmembraneHelical%3B Name%3D3
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313241_262119.0439.0TransmembraneHelical%3B Name%3D4
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313280_303119.0439.0TransmembraneHelical%3B Name%3D5
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313329_348119.0439.0TransmembraneHelical%3B Name%3D6
TgeneVIPR2chr7:158580694chr7:158851269ENST00000262178313361_380119.0439.0TransmembraneHelical%3B Name%3D7
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313127_151119.0439.0TransmembraneHelical%3B Name%3D1
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313159_178119.0439.0TransmembraneHelical%3B Name%3D2
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313204_227119.0439.0TransmembraneHelical%3B Name%3D3
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313241_262119.0439.0TransmembraneHelical%3B Name%3D4
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313280_303119.0439.0TransmembraneHelical%3B Name%3D5
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313329_348119.0439.0TransmembraneHelical%3B Name%3D6
TgeneVIPR2chr7:158580695chr7:158851269ENST00000262178313361_380119.0439.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-622736_739297.0894.0Compositional biasNote=Poly-Ser
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-622736_739297.0894.0Compositional biasNote=Poly-Ser
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-622191_370297.0894.0DomainSMP-LTD
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-622369_489297.0894.0DomainC2 1
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-622514_639297.0894.0DomainC2 2
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-622786_908297.0894.0DomainC2 3
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-622191_370297.0894.0DomainSMP-LTD
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-622369_489297.0894.0DomainC2 1
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-622514_639297.0894.0DomainC2 2
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-622786_908297.0894.0DomainC2 3
HgeneESYT2chr7:158580694chr7:158851269ENST00000251527-622149_921297.0894.0Topological domainCytoplasmic
HgeneESYT2chr7:158580695chr7:158851269ENST00000251527-622149_921297.0894.0Topological domainCytoplasmic
TgeneVIPR2chr7:158580694chr7:158851269ENST0000026217831324_126119.0439.0Topological domainExtracellular
TgeneVIPR2chr7:158580695chr7:158851269ENST0000026217831324_126119.0439.0Topological domainExtracellular


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Fusion Gene Sequence for ESYT2-VIPR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000251527_ENST00000262178_TCGA-GL-8500-01A_ESYT2_chr7_158580695_-_VIPR2_chr7_158851269_length(transcript)=4358nt_BP=957nt
AGTATCCACCCCGCCCGCTCCCGGTGACGTGCCAGCCCCAGGCCCACGCCGCTCCCGCCCCGCGTGATGACGCCACCGTCCCGGGCGGAG
GCGGGCGTGCGGCGGAGCCGCGTCCCCTCAGAGGGGCGCTGGCGCGGGGCTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCG
GCCGGGAGGGCAGCGCGGCACTGCGGGGCGATGAGCGGCGCCCGGGGCGAGGGCCCGGAGGCGGGCGCCGGCGGGGCTGGGGGCCGCGCG
GCGCCTGAGAACCCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTCGCGCTGCTGCTGCCCGTG
TACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTCCTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAG
GCCCTGCGCCTGTGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCCTGCGACCTGCCCGCCTGG
GTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAGACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTG
TTTCGAGAAACTATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTCGACGTGGGCCAGCAGCCC
CTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGACAAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGT
GAGATTGATTTGGAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATGCGGGTGATCCTGGAACCG
TTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTCTTCCTTAGGAAACCAATCACGTTTTATATTCTGGTGAAGGCCATTTAT
ACACTGGGCTACAGTGTCTCTCTGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTAC
ATCCACCTGAACCTGTTCCTGTCCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTG
CACTGCCCTGACCAGCCATCCTCCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTG
CTGGTGGAGGGGCTCTACCTCCACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGC
CTCCCCACCGTCTGCATCGGTGCATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCC
TGGTGGGTCATACGAATACCGATTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTA
ACATCCCCAGATGTCGGCGGCAACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCAC
TACATGGTGTTTGCCGTGTTTCCCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTG
GTGGCCGTCCTCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGC
CGGGATTACAGGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTC
CTGCAAACGGAGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGA
CGCCGGCTTCCTCCTTCCAGATGCCCGAGCACCGTGTCGGGCAGGTCAGCGCGGTCCTGACTCCGTCAAGCTGGTTGTCCACTAAACCCC
ATACCTGGAATTGGAGTCGTGTTGTCATTGACTCGATTTAAACTCCAGCATTTAGATAATCTTGTGCAAAATGTGTTTCAGCCGTATAGT
GGATCCACTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGACTGCAGTGGCCTGATCTCTGCTCCCTG
CAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCATAGCTGGGACTACAGGCGCCCGCCAACACGCCTGGCTAATTT
TTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATGGGCCCGCCTCGGCCTCCCA
AAGTGCTGGGATTAAGGCGTGAGCCACTGCGCCCGGCCCAAGAGAATAGGGGAGCCAAGGAGGAAATGTGGAAACGCAGTTGTGTGGCCC
AGCACGAGCCTGGGCGACCACCGGGTGACATCCGTCCCACATCAGGGCGGCCTCCCAGGTCCCATAAGGGTAGCCCCCTCATCTGCAGGA
CAGAGGGAAGCCAGTCAGGGCCCCCCTGACGTTAGGACCAGGAGAAATCAACAGGAGGGCAGCCCGTCCTCTCTCTTGGGGCGCCCACCC
GGCCCGGCTGAGCCCTGCCCCACCCAACTCCACAGGGCTGTTTTGCCTCCCCACGGAAGGCGGGCTGAGGAGACAACCAGATCAGGAGAG
CAAGGTCATGAAGGAGGGGACCTCTCCACACAGGTGTTCCGTGGGACCCTCAGCAGCTCTGGCTCTGCCTCAGGAGGTCACCTGCCGCCC
TGTGGGAGCCGCAGAGCCTGACGCTCAGCCCCAGGCCAGCTGCGGCCAGGCCTGCGGGCCCCTGGTGATGGGGTTACGTGGGGTGCGGGA
TACAGCTGAGTGGGAACCGGAAACCTATTCTCTTTTTAACAAAAATAATCTTAGGATAAGAATTATTTTAACAACATATAAAACTGTTTC
AAGCCCTCCTCCCCAGAGCTGGCGCTCAGCAGCCCTAGCGGCTGCTCCTTCAGGCGAAGGGTGGTTTGCAGATGTGGGGAGGGTGTCTGG
GGACGTTGCTGAGCCAGCTGCAGAAGGGTGGGGATATCAGGGCACAGTCTCCATGTGTGTGCCAAGCCCTGGCCCCCACAGCGCTCGATG
GACCTCAGCAAGCTGCCCAGCCCTGGCCCAGGTGCCCCGACTGTGGGACTCAGTTGTTCTGAGCACATTTGACTCCACTTTTCCCTTAAA
AATGAATGTCTTGTTCCTGTGCATTGGTGGCATCACAGACCCCAGCTGGGGCGCGATGTCAAAGGTCGGGACAGCTGTGCCGGGAGGCAG
CCACAGGGAAGCTCACACATCCTGTCAGTGTCACCTTGGTTTGCAAAACCCATATCCCCGGTAAAATGAGGCCGGACAGAGGGGCTGTTA
GGACAGCAAAGCAGCAGTGTCCAGAGACCCCTCAATCCCCAAAGGTCCGCACCCTGTCCTGCACACCCTGGGCCACGCCGGCCACACCCC
TCTGCTGCAACAAGCTCATCCCTGGACTTCTGGGAGAATGAACCCGAGGTTGGTTTGGGGAGACAGGTGAGGCGGTCGGATCTACAGAAC
AACCCACCATTTCTGGGGGCCGCAGAGGATCCATCACAGACGGATACTGGGGAGTAAACGGCCCAGGCCAGGTGCCCAGGAAAGGACGGC
TGAGCATGTGGAGCGAGAGGGAGGCAGGTGGACGCTGCAGACCCCAGGTTCAGTGCGGCCCCTCGGCTGTTCCTCCCCTGTAGGGTTTGG
ACAGACCCACCCCCAGCCTTGCCCAGCTTTCAAAGGACAAAAGGGAGCATCCCCCACCTACTCTCAGGTTTTTGAGGAAACAAAGATTTG
TGGTAACTGAAGGTGTTGGGTCAGTGGCCAGGTGCCGACACTGAGCTGTGACCCAGAGGGGACGCTGAGGAAGTGGGCGTGAGTGGACGT
GTCAGGTGGTTACCAGGCACTGGTTGTTGATGGTCGGTGGTTGGGTGTGGGCAGTCATCAGTCATCAGGTGTGCTCAGGGGACAATCTCC
CCTCAACCGCACATGTGCCACTGTTCAGCGGAGCTGACTGGTTTCTCCTGGTAGAGGGGCCGGCTGTTTCCTGACAGATGCCTGGTGAGC
AGGGGAAGCAGGACCCAGTGGTCAGCAGGTGTCTTTAACTGTCATTGTGTGTGGAATGTCGCAGACTCCTCCACGTGGCGGGAATGAGCT

>In-frame_ENST00000251527_ENST00000262178_TCGA-GL-8500-01A_ESYT2_chr7_158580695_-_VIPR2_chr7_158851269_length(amino acids)=616AA_start in transcript=66_stop in transcript=1916
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLAR
SFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHG
TMRVILEPLIGDMPLVGALSIFFLRKPITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDV
LYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCW
DTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELC

--------------------------------------------------------------
>In-frame_ENST00000251527_ENST00000377633_TCGA-GL-8500-01A_ESYT2_chr7_158580695_-_VIPR2_chr7_158851269_length(transcript)=2078nt_BP=957nt
AGTATCCACCCCGCCCGCTCCCGGTGACGTGCCAGCCCCAGGCCCACGCCGCTCCCGCCCCGCGTGATGACGCCACCGTCCCGGGCGGAG
GCGGGCGTGCGGCGGAGCCGCGTCCCCTCAGAGGGGCGCTGGCGCGGGGCTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCG
GCCGGGAGGGCAGCGCGGCACTGCGGGGCGATGAGCGGCGCCCGGGGCGAGGGCCCGGAGGCGGGCGCCGGCGGGGCTGGGGGCCGCGCG
GCGCCTGAGAACCCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTCGCGCTGCTGCTGCCCGTG
TACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTCCTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAG
GCCCTGCGCCTGTGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCCTGCGACCTGCCCGCCTGG
GTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAGACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTG
TTTCGAGAAACTATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTCGACGTGGGCCAGCAGCCC
CTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGACAAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGT
GAGATTGATTTGGAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATGCGGGTGATCCTGGAACCG
TTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTCTTCCTTAGGAAACCAATCACGTTTTATATTCTGGTGAAGGCCATTTAT
ACACTGGGCTACAGTGTCTCTCTGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTAC
ATCCACCTGAACCTGTTCCTGTCCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTG
CACTGCCCTGACCAGCCATCCTCCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTG
CTGGTGGAGGGGCTCTACCTCCACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGC
CTCCCCACCGTCTGCATCGGTGCATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCC
TGGTGGGTCATACGAATACCGATTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTA
ACATCCCCAGATGTCGGCGGCAACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCAC
TACATGGTGTTTGCCGTGTTTCCCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTG
GTGGCCGTCCTCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGC
CGGGATTACAGGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTC
CTGCAAACGGAGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGA
CGCCGGCTTCCTCCTTCCAGATGCCCGAGCACCGTGTCGGGCAGGTCAGCGCGGTCCTGACTCCGTCAAGCTGGTTGTCCACTAAACCCC

>In-frame_ENST00000251527_ENST00000377633_TCGA-GL-8500-01A_ESYT2_chr7_158580695_-_VIPR2_chr7_158851269_length(amino acids)=616AA_start in transcript=66_stop in transcript=1916
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLAR
SFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHG
TMRVILEPLIGDMPLVGALSIFFLRKPITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDV
LYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCW
DTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELC

--------------------------------------------------------------
>In-frame_ENST00000251527_ENST00000402066_TCGA-GL-8500-01A_ESYT2_chr7_158580695_-_VIPR2_chr7_158851269_length(transcript)=2015nt_BP=957nt
AGTATCCACCCCGCCCGCTCCCGGTGACGTGCCAGCCCCAGGCCCACGCCGCTCCCGCCCCGCGTGATGACGCCACCGTCCCGGGCGGAG
GCGGGCGTGCGGCGGAGCCGCGTCCCCTCAGAGGGGCGCTGGCGCGGGGCTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCG
GCCGGGAGGGCAGCGCGGCACTGCGGGGCGATGAGCGGCGCCCGGGGCGAGGGCCCGGAGGCGGGCGCCGGCGGGGCTGGGGGCCGCGCG
GCGCCTGAGAACCCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTCGCGCTGCTGCTGCCCGTG
TACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTCCTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAG
GCCCTGCGCCTGTGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCCTGCGACCTGCCCGCCTGG
GTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAGACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTG
TTTCGAGAAACTATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTCGACGTGGGCCAGCAGCCC
CTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGACAAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGT
GAGATTGATTTGGAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATGCGGGTGATCCTGGAACCG
TTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTCTTCCTTAGGAAACCAATCACGTTTTATATTCTGGTGAAGGCCATTTAT
ACACTGGGCTACAGTGTCTCTCTGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTAC
ATCCACCTGAACCTGTTCCTGTCCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTG
CACTGCCCTGACCAGCCATCCTCCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTG
CTGGTGGAGGGGCTCTACCTCCACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGC
CTCCCCACCGTCTGCATCGGTGCATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCC
TGGTGGGTCATACGAATACCGATTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTA
ACATCCCCAGATGTCGGCGGCAACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCAC
TACATGGTGTTTGCCGTGTTTCCCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTG
GTGGCCGTCCTCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGC
CGGGATTACAGGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTC
CTGCAAACGGAGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGA

>In-frame_ENST00000251527_ENST00000402066_TCGA-GL-8500-01A_ESYT2_chr7_158580695_-_VIPR2_chr7_158851269_length(amino acids)=616AA_start in transcript=66_stop in transcript=1916
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLAR
SFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHG
TMRVILEPLIGDMPLVGALSIFFLRKPITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDV
LYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCW
DTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELC

--------------------------------------------------------------
>In-frame_ENST00000251527_ENST00000262178_TCGA-GL-8500_ESYT2_chr7_158580694_-_VIPR2_chr7_158851269_length(transcript)=4358nt_BP=957nt
AGTATCCACCCCGCCCGCTCCCGGTGACGTGCCAGCCCCAGGCCCACGCCGCTCCCGCCCCGCGTGATGACGCCACCGTCCCGGGCGGAG
GCGGGCGTGCGGCGGAGCCGCGTCCCCTCAGAGGGGCGCTGGCGCGGGGCTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCG
GCCGGGAGGGCAGCGCGGCACTGCGGGGCGATGAGCGGCGCCCGGGGCGAGGGCCCGGAGGCGGGCGCCGGCGGGGCTGGGGGCCGCGCG
GCGCCTGAGAACCCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTCGCGCTGCTGCTGCCCGTG
TACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTCCTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAG
GCCCTGCGCCTGTGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCCTGCGACCTGCCCGCCTGG
GTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAGACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTG
TTTCGAGAAACTATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTCGACGTGGGCCAGCAGCCC
CTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGACAAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGT
GAGATTGATTTGGAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATGCGGGTGATCCTGGAACCG
TTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTCTTCCTTAGGAAACCAATCACGTTTTATATTCTGGTGAAGGCCATTTAT
ACACTGGGCTACAGTGTCTCTCTGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTAC
ATCCACCTGAACCTGTTCCTGTCCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTG
CACTGCCCTGACCAGCCATCCTCCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTG
CTGGTGGAGGGGCTCTACCTCCACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGC
CTCCCCACCGTCTGCATCGGTGCATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCC
TGGTGGGTCATACGAATACCGATTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTA
ACATCCCCAGATGTCGGCGGCAACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCAC
TACATGGTGTTTGCCGTGTTTCCCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTG
GTGGCCGTCCTCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGC
CGGGATTACAGGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTC
CTGCAAACGGAGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGA
CGCCGGCTTCCTCCTTCCAGATGCCCGAGCACCGTGTCGGGCAGGTCAGCGCGGTCCTGACTCCGTCAAGCTGGTTGTCCACTAAACCCC
ATACCTGGAATTGGAGTCGTGTTGTCATTGACTCGATTTAAACTCCAGCATTTAGATAATCTTGTGCAAAATGTGTTTCAGCCGTATAGT
GGATCCACTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGACTGCAGTGGCCTGATCTCTGCTCCCTG
CAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCATAGCTGGGACTACAGGCGCCCGCCAACACGCCTGGCTAATTT
TTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATGGGCCCGCCTCGGCCTCCCA
AAGTGCTGGGATTAAGGCGTGAGCCACTGCGCCCGGCCCAAGAGAATAGGGGAGCCAAGGAGGAAATGTGGAAACGCAGTTGTGTGGCCC
AGCACGAGCCTGGGCGACCACCGGGTGACATCCGTCCCACATCAGGGCGGCCTCCCAGGTCCCATAAGGGTAGCCCCCTCATCTGCAGGA
CAGAGGGAAGCCAGTCAGGGCCCCCCTGACGTTAGGACCAGGAGAAATCAACAGGAGGGCAGCCCGTCCTCTCTCTTGGGGCGCCCACCC
GGCCCGGCTGAGCCCTGCCCCACCCAACTCCACAGGGCTGTTTTGCCTCCCCACGGAAGGCGGGCTGAGGAGACAACCAGATCAGGAGAG
CAAGGTCATGAAGGAGGGGACCTCTCCACACAGGTGTTCCGTGGGACCCTCAGCAGCTCTGGCTCTGCCTCAGGAGGTCACCTGCCGCCC
TGTGGGAGCCGCAGAGCCTGACGCTCAGCCCCAGGCCAGCTGCGGCCAGGCCTGCGGGCCCCTGGTGATGGGGTTACGTGGGGTGCGGGA
TACAGCTGAGTGGGAACCGGAAACCTATTCTCTTTTTAACAAAAATAATCTTAGGATAAGAATTATTTTAACAACATATAAAACTGTTTC
AAGCCCTCCTCCCCAGAGCTGGCGCTCAGCAGCCCTAGCGGCTGCTCCTTCAGGCGAAGGGTGGTTTGCAGATGTGGGGAGGGTGTCTGG
GGACGTTGCTGAGCCAGCTGCAGAAGGGTGGGGATATCAGGGCACAGTCTCCATGTGTGTGCCAAGCCCTGGCCCCCACAGCGCTCGATG
GACCTCAGCAAGCTGCCCAGCCCTGGCCCAGGTGCCCCGACTGTGGGACTCAGTTGTTCTGAGCACATTTGACTCCACTTTTCCCTTAAA
AATGAATGTCTTGTTCCTGTGCATTGGTGGCATCACAGACCCCAGCTGGGGCGCGATGTCAAAGGTCGGGACAGCTGTGCCGGGAGGCAG
CCACAGGGAAGCTCACACATCCTGTCAGTGTCACCTTGGTTTGCAAAACCCATATCCCCGGTAAAATGAGGCCGGACAGAGGGGCTGTTA
GGACAGCAAAGCAGCAGTGTCCAGAGACCCCTCAATCCCCAAAGGTCCGCACCCTGTCCTGCACACCCTGGGCCACGCCGGCCACACCCC
TCTGCTGCAACAAGCTCATCCCTGGACTTCTGGGAGAATGAACCCGAGGTTGGTTTGGGGAGACAGGTGAGGCGGTCGGATCTACAGAAC
AACCCACCATTTCTGGGGGCCGCAGAGGATCCATCACAGACGGATACTGGGGAGTAAACGGCCCAGGCCAGGTGCCCAGGAAAGGACGGC
TGAGCATGTGGAGCGAGAGGGAGGCAGGTGGACGCTGCAGACCCCAGGTTCAGTGCGGCCCCTCGGCTGTTCCTCCCCTGTAGGGTTTGG
ACAGACCCACCCCCAGCCTTGCCCAGCTTTCAAAGGACAAAAGGGAGCATCCCCCACCTACTCTCAGGTTTTTGAGGAAACAAAGATTTG
TGGTAACTGAAGGTGTTGGGTCAGTGGCCAGGTGCCGACACTGAGCTGTGACCCAGAGGGGACGCTGAGGAAGTGGGCGTGAGTGGACGT
GTCAGGTGGTTACCAGGCACTGGTTGTTGATGGTCGGTGGTTGGGTGTGGGCAGTCATCAGTCATCAGGTGTGCTCAGGGGACAATCTCC
CCTCAACCGCACATGTGCCACTGTTCAGCGGAGCTGACTGGTTTCTCCTGGTAGAGGGGCCGGCTGTTTCCTGACAGATGCCTGGTGAGC
AGGGGAAGCAGGACCCAGTGGTCAGCAGGTGTCTTTAACTGTCATTGTGTGTGGAATGTCGCAGACTCCTCCACGTGGCGGGAATGAGCT

>In-frame_ENST00000251527_ENST00000262178_TCGA-GL-8500_ESYT2_chr7_158580694_-_VIPR2_chr7_158851269_length(amino acids)=616AA_start in transcript=66_stop in transcript=1916
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLAR
SFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHG
TMRVILEPLIGDMPLVGALSIFFLRKPITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDV
LYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCW
DTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELC

--------------------------------------------------------------
>In-frame_ENST00000251527_ENST00000377633_TCGA-GL-8500_ESYT2_chr7_158580694_-_VIPR2_chr7_158851269_length(transcript)=2078nt_BP=957nt
AGTATCCACCCCGCCCGCTCCCGGTGACGTGCCAGCCCCAGGCCCACGCCGCTCCCGCCCCGCGTGATGACGCCACCGTCCCGGGCGGAG
GCGGGCGTGCGGCGGAGCCGCGTCCCCTCAGAGGGGCGCTGGCGCGGGGCTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCG
GCCGGGAGGGCAGCGCGGCACTGCGGGGCGATGAGCGGCGCCCGGGGCGAGGGCCCGGAGGCGGGCGCCGGCGGGGCTGGGGGCCGCGCG
GCGCCTGAGAACCCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTCGCGCTGCTGCTGCCCGTG
TACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTCCTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAG
GCCCTGCGCCTGTGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCCTGCGACCTGCCCGCCTGG
GTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAGACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTG
TTTCGAGAAACTATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTCGACGTGGGCCAGCAGCCC
CTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGACAAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGT
GAGATTGATTTGGAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATGCGGGTGATCCTGGAACCG
TTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTCTTCCTTAGGAAACCAATCACGTTTTATATTCTGGTGAAGGCCATTTAT
ACACTGGGCTACAGTGTCTCTCTGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTAC
ATCCACCTGAACCTGTTCCTGTCCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTG
CACTGCCCTGACCAGCCATCCTCCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTG
CTGGTGGAGGGGCTCTACCTCCACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGC
CTCCCCACCGTCTGCATCGGTGCATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCC
TGGTGGGTCATACGAATACCGATTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTA
ACATCCCCAGATGTCGGCGGCAACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCAC
TACATGGTGTTTGCCGTGTTTCCCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTG
GTGGCCGTCCTCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGC
CGGGATTACAGGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTC
CTGCAAACGGAGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGA
CGCCGGCTTCCTCCTTCCAGATGCCCGAGCACCGTGTCGGGCAGGTCAGCGCGGTCCTGACTCCGTCAAGCTGGTTGTCCACTAAACCCC

>In-frame_ENST00000251527_ENST00000377633_TCGA-GL-8500_ESYT2_chr7_158580694_-_VIPR2_chr7_158851269_length(amino acids)=616AA_start in transcript=66_stop in transcript=1916
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLAR
SFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHG
TMRVILEPLIGDMPLVGALSIFFLRKPITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDV
LYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCW
DTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELC

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>In-frame_ENST00000251527_ENST00000402066_TCGA-GL-8500_ESYT2_chr7_158580694_-_VIPR2_chr7_158851269_length(transcript)=2015nt_BP=957nt
AGTATCCACCCCGCCCGCTCCCGGTGACGTGCCAGCCCCAGGCCCACGCCGCTCCCGCCCCGCGTGATGACGCCACCGTCCCGGGCGGAG
GCGGGCGTGCGGCGGAGCCGCGTCCCCTCAGAGGGGCGCTGGCGCGGGGCTGAGCCGCCCGGGATCAGCGCGAGCACCCAGCCCGCCTCG
GCCGGGAGGGCAGCGCGGCACTGCGGGGCGATGAGCGGCGCCCGGGGCGAGGGCCCGGAGGCGGGCGCCGGCGGGGCTGGGGGCCGCGCG
GCGCCTGAGAACCCCGGGGGCGTGCTGAGCGTGGAGCTGCCCGGGCTGCTGGCGCAGCTGGCGCGGAGCTTCGCGCTGCTGCTGCCCGTG
TACGCGCTGGGCTACCTGGGGCTCAGCTTCAGCTGGGTTCTCCTCGCGCTCGCGCTGCTCGCCTGGTGTCGCCGCAGCCGCGGCCTCAAG
GCCCTGCGCCTGTGCCGCGCGCTGGCGCTGCTGGAAGACGAGGAGCGCGTCGTGCGCCTGGGGGTGCGCGCCTGCGACCTGCCCGCCTGG
GTTCATTTTCCAGACACTGAAAGAGCAGAATGGCTAAATAAGACTGTAAAACACATGTGGCCTTTCATTTGCCAATTTATAGAGAAGTTG
TTTCGAGAAACTATAGAACCAGCCGTGCGGGGAGCAAACACCCACCTTAGCACCTTTAGTTTCACGAAGGTCGACGTGGGCCAGCAGCCC
CTCAGGATCAATGGTGTTAAGGTATACACTGAAAATGTAGACAAAAGGCAAATTATTTTGGACCTTCAGATTAGTTTTGTAGGAAATTGT
GAGATTGATTTGGAGATCAAACGATATTTTTGTAGAGCTGGTGTGAAAAGTATCCAGATTCATGGTACCATGCGGGTGATCCTGGAACCG
TTGATTGGAGATATGCCCTTAGTTGGAGCTTTGTCTATCTTCTTCCTTAGGAAACCAATCACGTTTTATATTCTGGTGAAGGCCATTTAT
ACACTGGGCTACAGTGTCTCTCTGATGTCTCTTGCAACAGGAAGCATAATTCTGTGCCTCTTCAGGAAGCTGCACTGCACCAGGAATTAC
ATCCACCTGAACCTGTTCCTGTCCTTCATCCTGAGAGCCATCTCAGTGCTGGTCAAGGACGACGTTCTCTACTCCAGCTCTGGCACGTTG
CACTGCCCTGACCAGCCATCCTCCTGGGTGGGCTGCAAGCTGAGCCTGGTCTTCCTGCAGTACTGCATCATGGCCAACTTCTTCTGGCTG
CTGGTGGAGGGGCTCTACCTCCACACCCTCCTGGTGGCCATGCTCCCCCCTAGAAGGTGCTTCCTGGCCTACCTCCTGATCGGATGGGGC
CTCCCCACCGTCTGCATCGGTGCATGGACTGCGGCCAGGCTCTACTTAGAAGACACCGGTTGCTGGGATACAAACGACCACAGTGTGCCC
TGGTGGGTCATACGAATACCGATTTTAATTTCCATCATCGTCAATTTTGTCCTTTTCATTAGTATTATACGAATTTTGCTGCAGAAGTTA
ACATCCCCAGATGTCGGCGGCAACGACCAGTCTCAGTACAAGAGGCTGGCCAAGTCCACGCTCCTGCTTATCCCGCTGTTCGGCGTCCAC
TACATGGTGTTTGCCGTGTTTCCCATCAGCATCTCCTCCAAATACCAGATACTGTTTGAGCTGTGCCTCGGGTCGTTCCAGGGCCTGGTG
GTGGCCGTCCTCTACTGTTTCCTGAACAGTGAGGTGCAGTGCGAGCTGAAGCGAAAATGGCGAAGCCGGTGCCCGACCCCGTCCGCGAGC
CGGGATTACAGGGTCTGCGGTTCCTCCTTCTCCCGCAACGGCTCGGAGGGCGCCCTGCAGTTCCACCGCGGCTCCCGCGCCCAGTCCTTC
CTGCAAACGGAGACCTCGGTCATCTAGCCCCACCCCTGCCTGTCGGACGCGGCGGGAGGCCCACGGTTCGGGGCTTCTGCGGGGCTGAGA

>In-frame_ENST00000251527_ENST00000402066_TCGA-GL-8500_ESYT2_chr7_158580694_-_VIPR2_chr7_158851269_length(amino acids)=616AA_start in transcript=66_stop in transcript=1916
MTPPSRAEAGVRRSRVPSEGRWRGAEPPGISASTQPASAGRAARHCGAMSGARGEGPEAGAGGAGGRAAPENPGGVLSVELPGLLAQLAR
SFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPF
ICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHG
TMRVILEPLIGDMPLVGALSIFFLRKPITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDV
LYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCW
DTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELC

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Fusion Gene PPI Analysis for ESYT2-VIPR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ESYT2-VIPR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ESYT2-VIPR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneVIPR2C0005586Bipolar Disorder1PSYGENET
TgeneVIPR2C0036341Schizophrenia1CTD_human