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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ETV4-CCL16 (FusionGDB2 ID:27652)

Fusion Gene Summary for ETV4-CCL16

Fusion gene summary

Fusion gene information	Fusion gene name: ETV4-CCL16
	Fusion gene ID: 27652
		Hgene	Tgene
	Gene symbol	ETV4	CCL16
	Gene ID	2118	6360
	Gene name	ETS variant transcription factor 4	C-C motif chemokine ligand 16
	Synonyms	E1A-F\|E1AF\|PEA3\|PEAS3	CKb12\|HCC-4\|ILINCK\|LCC-1\|LEC\|LMC\|Mtn-1\|NCC-4\|NCC4\|SCYA16\|SCYL4
	Cytomap	17q21.31	17q12
	Type of gene	protein-coding	protein-coding
	Description	ETS translocation variant 4ETS variant 4EWS protein/E1A enhancer binding protein chimeraadenovirus E1A enhancer-binding proteinets variant gene 4 (E1A enhancer-binding protein, E1AF)polyomavirus enhancer activator 3 homolog	C-C motif chemokine 16IL-10-inducible chemokinechemokine (C-C motif) ligand 16chemokine LECliver CC chemokine-1liver-expressed chemokinelymphocyte and monocyte chemoattractantmonotactin-1new CC chemokine 4small inducible cytokine subfamily A (Cys
	Modification date	20200313	20200313
	UniProtAcc	P43268	.
	Ensembl transtripts involved in fusion gene	ENST00000319349, ENST00000393664, ENST00000538265, ENST00000545954, ENST00000545089, ENST00000591713, ENST00000586826,	ENST00000293275,
Fusion gene scores	* DoF score	4 X 4 X 3=48	1 X 1 X 1=1
	# samples	7	1
	** MAII score	log2(7/48*10)=0.54432051622381 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(1/1*10)=3.32192809488736
Context	PubMed: ETV4 [Title/Abstract] AND CCL16 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ETV4(41610042)-CCL16(34305299), # samples:1
Anticipated loss of major functional domain due to fusion event.	ETV4-CCL16 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. ETV4-CCL16 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ETV4	GO:0045944	positive regulation of transcription by RNA polymerase II	24983502

Fusion gene breakpoints across ETV4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCL16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0T3-01A	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-

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Fusion Gene ORF analysis for ETV4-CCL16

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000319349	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-
In-frame	ENST00000393664	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-
Frame-shift	ENST00000538265	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-
Frame-shift	ENST00000545954	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-
In-frame	ENST00000545089	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-
In-frame	ENST00000591713	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-
intron-3CDS	ENST00000586826	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000319349	ETV4	chr17	41610042	-	ENST00000293275	CCL16	chr17	34305299	-	2464	1110	80	1396	438
ENST00000393664	ETV4	chr17	41610042	-	ENST00000293275	CCL16	chr17	34305299	-	2219	865	54	1151	365
ENST00000545089	ETV4	chr17	41610042	-	ENST00000293275	CCL16	chr17	34305299	-	2099	745	96	1031	311
ENST00000591713	ETV4	chr17	41610042	-	ENST00000293275	CCL16	chr17	34305299	-	2255	901	90	1187	365

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000319349	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-	0.006257404	0.99374264
ENST00000393664	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-	0.005593568	0.99440646
ENST00000545089	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-	0.003392507	0.99660754
ENST00000591713	ENST00000293275	ETV4	chr17	41610042	-	CCL16	chr17	34305299	-	0.006393126	0.9936069

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Fusion Genomic Features for ETV4-CCL16

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ETV4-CCL16

Go to
FGviewer for the breakpoints of chr17:41610042-chr17:34305299
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ETV4 P43268	.
FUNCTION: Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269\|PubMed:19307308, ECO:0000269\|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269\|PubMed:8441666}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000319349

148_244

270.3333333333333

485.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000319349

49_75

270.3333333333333

485.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000393664

148_244

270.3333333333333

485.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000393664

49_75

270.3333333333333

485.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000538265

49_75

231.33333333333334

446.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000545954

49_75

231.33333333333334

446.0

Compositional bias

Note=Asp/Glu-rich (acidic)

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000591713

148_244

270.3333333333333

485.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000591713

49_75

270.3333333333333

485.0

Compositional bias

Note=Asp/Glu-rich (acidic)

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000538265

148_244

231.33333333333334

446.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000545954

148_244

231.33333333333334

446.0

Compositional bias

Note=Gln-rich

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000319349

341_421

270.3333333333333

485.0

DNA binding

ETS

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000393664

341_421

270.3333333333333

485.0

DNA binding

ETS

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000538265

341_421

231.33333333333334

446.0

DNA binding

ETS

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000545954

341_421

231.33333333333334

446.0

DNA binding

ETS

Hgene

ETV4

chr17:41610042

chr17:34305299

ENST00000591713

341_421

270.3333333333333

485.0

DNA binding

ETS

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Fusion Gene Sequence for ETV4-CCL16

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000319349_ENST00000293275_TCGA-A2-A0T3-01A_ETV4_chr17_41610042_-_CCL16_chr17_34305299_length(transcript)=2464nt_BP=1110nt
GAAACAAAGGGAAACGGGGGGCGGTGTGGCGGGGCGGGGGGTGGAGAGCTGAGGCCGAGCGAAGGAAATGCACCAATCAGCTGCTCCCCC
GGGCTCACAACTGTCTGCTGCGCCCGAAAAACAAGTCGGTGCGCTGGGGACCCGGGGCCGGGGCCGCCTTACTCCGGCCTAGCCCCGCGG
CCCTCGGTGCGGGCTCCAGGGCATGCTCGGGACCCCCCGCGGCTCCAGCCCAGACGCCCCGGCCTCAGGTCTCGGCCCCCGCTTGGGGCC
CCGGCCGTGCGGCCGGAGGGAGCGGCCGGATGGAGCGGAGGATGAAAGCCGGATACTTGGACCAGCAAGTGCCCTACACCTTCAGCAGCA
AATCGCCCGGAAATGGGAGCTTGCGCGAAGCGCTGATCGGCCCGCTGGGGAAGCTCATGGACCCGGGCTCCCTGCCGCCCCTCGACTCTG
AAGATCTCTTCCAGGATCTAAGTCACTTCCAGGAGACGTGGCTCGCTGAAGCTCAGGTACCAGACAGTGATGAGCAGTTTGTTCCTGATT
TCCATTCAGAAAACCTAGCTTTCCACAGCCCCACCACCAGGATCAAGAAGGAGCCCCAGAGTCCCCGCACAGACCCGGCCCTGTCCTGCA
GCAGGAAGCCGCCACTCCCCTACCACCATGGCGAGCAGTGCCTTTACTCCAGTGCCTATGACCCCCCCAGACAAATCGCCATCAAGTCCC
CTGCCCCTGGTGCCCTTGGACAGTCGCCCCTACAGCCCTTTCCCCGGGCAGAGCAACGGAATTTCCTGAGATCCTCTGGCACCTCCCAGC
CCCACCCTGGCCATGGGTACCTCGGGGAACATAGCTCCGTCTTCCAGCAGCCCCTGGACATTTGCCACTCCTTCACATCTCAGGGAGGGG
GCCGGGAACCCCTCCCAGCCCCCTACCAACACCAGCTGTCGGAGCCCTGCCCACCCTATCCCCAGCAGAGCTTTAAGCAAGAATACCATG
ATCCCCTGTATGAACAGGCGGGCCAGCCAGCCGTGGACCAGGGTGGGGTCAATGGGCACAGGTACCCAGGGGCGGGGGTGGTGATCAAAC
AGGAACAGACGGACTTCGCCTACGACTCAGAAGTTCCTGAGTGGGTGAACACCCCATCCACCTGCTGCCTGAAGTATTATGAGAAAGTGT
TGCCAAGGAGACTAGTGGTGGGATACAGAAAGGCCCTCAACTGTCACCTGCCAGCAATCATCTTCGTCACCAAGAGGAACCGAGAAGTCT
GCACCAACCCCAATGACGACTGGGTCCAAGAGTACATCAAGGATCCCAACCTACCTTTGCTGCCTACCAGGAACTTGTCCACGGTTAAAA
TTATTACAGCAAAGAATGGTCAACCCCAGCTCCTCAACTCCCAGTGATGACCAGGCTTTAGTGGAAGCCCTTGTTTACAGAAGAGAGGGG
TAAACCTATGAAAACAGGGGAAGCCTTATTAGGCTGAAACTAGCCAGTCACATTGAGAGAAGCAGAACAATGATCAAAATAAAGGAGAAG
TATTTCGAATATTTTCTCAATCTTAGGAGGAAATACCAAAGTTAAGGGACGTGGGCAGAGGTACGCTCTTTTATTTTTATATTTATATTT
TTATTTTTTTGAGATAGGGTCTTACTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTTGATCTTGGCTCACTGTAACC
TCCACCTCCCAGGCTCAAGTGATCCTCCCACCCCAGCCTCCTGAGTAGCTGGGACTACAGGCTTGCGCCACCACACCTGGCTAATTTTTG
TATTTTTGGTAGAGACGGGATTCTACCATGTTGCCCAGGCTGGTCTCAAACTCGTGTGCCCAAGCAATCCACCTGCCTCAGCCTTCCAAA
AGTGCTGGGATTACAGGCGTGAGCCACCACATCCGGCCAGTGCACTCTTAATACACAGAAAAATATATTTCACATCCTTCTCCTGCTCTC
TTTCAATTCCTCACTTCACACCAGTACACAAGCCATTCTAAATACTTAGCCAGTTTCCAGCCTTCCAGATGATCTTTGCCCTCTGGGTCT
TGACCCATTAAGAGCCCCATAGAACTCTTGATTTTTCCTGTCCATCTTTATGGATTTTTCTGGATCTATATTTTCTTCAATTATTCTTTC
ATTTTATAATGCAACTTTTTCATAGGAAGTCCGGATGGGAATATTCACATTAATCATTTTTGCAGAGACTTTGCTAGATCCTCTCATATT
TTGTCTTCCTCAGGGTGGCAGGGGTACAGAGAGTGCCTGATTGGAAAAAAAAAAAAAAGAGAGAGAGAGAGAAGAAGAAGAAGAAGAGAC
ACAAATCTCTACCTCCCATGTTAAGCTTTGCAGGACAGGGAAAGAAAGGGTATGAGACACGGCTAGGGGTAAACTCTTAGTCCAAAACCC

>In-frame_ENST00000319349_ENST00000293275_TCGA-A2-A0T3-01A_ETV4_chr17_41610042_-_CCL16_chr17_34305299_length(amino acids)=438AA_start in transcript=80_stop in transcript=1396
MLPRAHNCLLRPKNKSVRWGPGAGAALLRPSPAALGAGSRACSGPPAAPAQTPRPQVSAPAWGPGRAAGGSGRMERRMKAGYLDQQVPYT
FSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSPRTDPA
LSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGEHSSVFQQPLDICHSFTS
QGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSEVPEWVNTPSTCCLKYY

--------------------------------------------------------------
>In-frame_ENST00000393664_ENST00000293275_TCGA-A2-A0T3-01A_ETV4_chr17_41610042_-_CCL16_chr17_34305299_length(transcript)=2219nt_BP=865nt
CAGGTCTCGGCCCCCGCTTGGGGCCCCGGCCGTGCGGCCGGAGGGAGCGGCCGGATGGAGCGGAGGATGAAAGCCGGATACTTGGACCAG
CAAGTGCCCTACACCTTCAGCAGCAAATCGCCCGGAAATGGGAGCTTGCGCGAAGCGCTGATCGGCCCGCTGGGGAAGCTCATGGACCCG
GGCTCCCTGCCGCCCCTCGACTCTGAAGATCTCTTCCAGGATCTAAGTCACTTCCAGGAGACGTGGCTCGCTGAAGCTCAGGTACCAGAC
AGTGATGAGCAGTTTGTTCCTGATTTCCATTCAGAAAACCTAGCTTTCCACAGCCCCACCACCAGGATCAAGAAGGAGCCCCAGAGTCCC
CGCACAGACCCGGCCCTGTCCTGCAGCAGGAAGCCGCCACTCCCCTACCACCATGGCGAGCAGTGCCTTTACTCCAGTGCCTATGACCCC
CCCAGACAAATCGCCATCAAGTCCCCTGCCCCTGGTGCCCTTGGACAGTCGCCCCTACAGCCCTTTCCCCGGGCAGAGCAACGGAATTTC
CTGAGATCCTCTGGCACCTCCCAGCCCCACCCTGGCCATGGGTACCTCGGGGAACATAGCTCCGTCTTCCAGCAGCCCCTGGACATTTGC
CACTCCTTCACATCTCAGGGAGGGGGCCGGGAACCCCTCCCAGCCCCCTACCAACACCAGCTGTCGGAGCCCTGCCCACCCTATCCCCAG
CAGAGCTTTAAGCAAGAATACCATGATCCCCTGTATGAACAGGCGGGCCAGCCAGCCGTGGACCAGGGTGGGGTCAATGGGCACAGGTAC
CCAGGGGCGGGGGTGGTGATCAAACAGGAACAGACGGACTTCGCCTACGACTCAGAAGTTCCTGAGTGGGTGAACACCCCATCCACCTGC
TGCCTGAAGTATTATGAGAAAGTGTTGCCAAGGAGACTAGTGGTGGGATACAGAAAGGCCCTCAACTGTCACCTGCCAGCAATCATCTTC
GTCACCAAGAGGAACCGAGAAGTCTGCACCAACCCCAATGACGACTGGGTCCAAGAGTACATCAAGGATCCCAACCTACCTTTGCTGCCT
ACCAGGAACTTGTCCACGGTTAAAATTATTACAGCAAAGAATGGTCAACCCCAGCTCCTCAACTCCCAGTGATGACCAGGCTTTAGTGGA
AGCCCTTGTTTACAGAAGAGAGGGGTAAACCTATGAAAACAGGGGAAGCCTTATTAGGCTGAAACTAGCCAGTCACATTGAGAGAAGCAG
AACAATGATCAAAATAAAGGAGAAGTATTTCGAATATTTTCTCAATCTTAGGAGGAAATACCAAAGTTAAGGGACGTGGGCAGAGGTACG
CTCTTTTATTTTTATATTTATATTTTTATTTTTTTGAGATAGGGTCTTACTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCT
CACTTGATCTTGGCTCACTGTAACCTCCACCTCCCAGGCTCAAGTGATCCTCCCACCCCAGCCTCCTGAGTAGCTGGGACTACAGGCTTG
CGCCACCACACCTGGCTAATTTTTGTATTTTTGGTAGAGACGGGATTCTACCATGTTGCCCAGGCTGGTCTCAAACTCGTGTGCCCAAGC
AATCCACCTGCCTCAGCCTTCCAAAAGTGCTGGGATTACAGGCGTGAGCCACCACATCCGGCCAGTGCACTCTTAATACACAGAAAAATA
TATTTCACATCCTTCTCCTGCTCTCTTTCAATTCCTCACTTCACACCAGTACACAAGCCATTCTAAATACTTAGCCAGTTTCCAGCCTTC
CAGATGATCTTTGCCCTCTGGGTCTTGACCCATTAAGAGCCCCATAGAACTCTTGATTTTTCCTGTCCATCTTTATGGATTTTTCTGGAT
CTATATTTTCTTCAATTATTCTTTCATTTTATAATGCAACTTTTTCATAGGAAGTCCGGATGGGAATATTCACATTAATCATTTTTGCAG
AGACTTTGCTAGATCCTCTCATATTTTGTCTTCCTCAGGGTGGCAGGGGTACAGAGAGTGCCTGATTGGAAAAAAAAAAAAAAGAGAGAG
AGAGAGAAGAAGAAGAAGAAGAGACACAAATCTCTACCTCCCATGTTAAGCTTTGCAGGACAGGGAAAGAAAGGGTATGAGACACGGCTA

>In-frame_ENST00000393664_ENST00000293275_TCGA-A2-A0T3-01A_ETV4_chr17_41610042_-_CCL16_chr17_34305299_length(amino acids)=365AA_start in transcript=54_stop in transcript=1151
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHS
PTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGE
HSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDS
EVPEWVNTPSTCCLKYYEKVLPRRLVVGYRKALNCHLPAIIFVTKRNREVCTNPNDDWVQEYIKDPNLPLLPTRNLSTVKIITAKNGQPQ

--------------------------------------------------------------
>In-frame_ENST00000545089_ENST00000293275_TCGA-A2-A0T3-01A_ETV4_chr17_41610042_-_CCL16_chr17_34305299_length(transcript)=2099nt_BP=745nt
AGCCCTCCCTGGACGGTGTGCGAACGCAGCCCCCTCCCCCACCAGGTCTCGGCCCCCGCTTGGGGCCCCGGCCGTGCGGCCGGAGGGAGC
GGCCGGATGGAGCGGAGGATGAAAGCCGGATACTTGGACCAGCAAGTGCCCTACACCTTCAGCAGCAAATCGCCCGGAAATGGGAGCTTG
CGCGAAGCGCTGATCGGCCCGCTGGGGAAGCTCATGGACCCGGGCTCCCTGCCGCCCCTCGACTCTGAAGATCTCTTCCAGGATCTAAGT
CACTTCCAGGAGACGTGGCTCGCTGAAGCTCAGGTACCAGACAGTGATGAGCAGTTTGTTCCTGATTTCCATTCAGAAAACCTAGCTTTC
CACAGCCCCACCACCAGGATCAAGAAGGAGCCCCAGAGTCCCCGCACAGACCCGGCCCTGTCCTGCAGCAGGAAGCCGCCACTCCCCTAC
CACCATGGCGAGCAGTGCCTTTACTCCAGCTCCGTCTTCCAGCAGCCCCTGGACATTTGCCACTCCTTCACATCTCAGGGAGGGGGCCGG
GAACCCCTCCCAGCCCCCTACCAACACCAGCTGTCGGAGCCCTGCCCACCCTATCCCCAGCAGAGCTTTAAGCAAGAATACCATGATCCC
CTGTATGAACAGGCGGGCCAGCCAGCCGTGGACCAGGGTGGGGTCAATGGGCACAGGTACCCAGGGGCGGGGGTGGTGATCAAACAGGAA
CAGACGGACTTCGCCTACGACTCAGAAGTTCCTGAGTGGGTGAACACCCCATCCACCTGCTGCCTGAAGTATTATGAGAAAGTGTTGCCA
AGGAGACTAGTGGTGGGATACAGAAAGGCCCTCAACTGTCACCTGCCAGCAATCATCTTCGTCACCAAGAGGAACCGAGAAGTCTGCACC
AACCCCAATGACGACTGGGTCCAAGAGTACATCAAGGATCCCAACCTACCTTTGCTGCCTACCAGGAACTTGTCCACGGTTAAAATTATT
ACAGCAAAGAATGGTCAACCCCAGCTCCTCAACTCCCAGTGATGACCAGGCTTTAGTGGAAGCCCTTGTTTACAGAAGAGAGGGGTAAAC
CTATGAAAACAGGGGAAGCCTTATTAGGCTGAAACTAGCCAGTCACATTGAGAGAAGCAGAACAATGATCAAAATAAAGGAGAAGTATTT
CGAATATTTTCTCAATCTTAGGAGGAAATACCAAAGTTAAGGGACGTGGGCAGAGGTACGCTCTTTTATTTTTATATTTATATTTTTATT
TTTTTGAGATAGGGTCTTACTCTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTTGATCTTGGCTCACTGTAACCTCCAC
CTCCCAGGCTCAAGTGATCCTCCCACCCCAGCCTCCTGAGTAGCTGGGACTACAGGCTTGCGCCACCACACCTGGCTAATTTTTGTATTT
TTGGTAGAGACGGGATTCTACCATGTTGCCCAGGCTGGTCTCAAACTCGTGTGCCCAAGCAATCCACCTGCCTCAGCCTTCCAAAAGTGC
TGGGATTACAGGCGTGAGCCACCACATCCGGCCAGTGCACTCTTAATACACAGAAAAATATATTTCACATCCTTCTCCTGCTCTCTTTCA
ATTCCTCACTTCACACCAGTACACAAGCCATTCTAAATACTTAGCCAGTTTCCAGCCTTCCAGATGATCTTTGCCCTCTGGGTCTTGACC
CATTAAGAGCCCCATAGAACTCTTGATTTTTCCTGTCCATCTTTATGGATTTTTCTGGATCTATATTTTCTTCAATTATTCTTTCATTTT
ATAATGCAACTTTTTCATAGGAAGTCCGGATGGGAATATTCACATTAATCATTTTTGCAGAGACTTTGCTAGATCCTCTCATATTTTGTC
TTCCTCAGGGTGGCAGGGGTACAGAGAGTGCCTGATTGGAAAAAAAAAAAAAAGAGAGAGAGAGAGAAGAAGAAGAAGAAGAGACACAAA
TCTCTACCTCCCATGTTAAGCTTTGCAGGACAGGGAAAGAAAGGGTATGAGACACGGCTAGGGGTAAACTCTTAGTCCAAAACCCAAGCA

>In-frame_ENST00000545089_ENST00000293275_TCGA-A2-A0T3-01A_ETV4_chr17_41610042_-_CCL16_chr17_34305299_length(amino acids)=311AA_start in transcript=96_stop in transcript=1031
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHS
PTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLY
EQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDSEVPEWVNTPSTCCLKYYEKVLPRRLVVGYRKALNCHLPAIIFVTKRNREVCTNP

--------------------------------------------------------------
>In-frame_ENST00000591713_ENST00000293275_TCGA-A2-A0T3-01A_ETV4_chr17_41610042_-_CCL16_chr17_34305299_length(transcript)=2255nt_BP=901nt
GCAGAAAGCAGAAACGGCGAGCCCGGCTCCTGGGAGCAGGTCTCGGCCCCCGCTTGGGGCCCCGGCCGTGCGGCCGGAGGGAGCGGCCGG
ATGGAGCGGAGGATGAAAGCCGGATACTTGGACCAGCAAGTGCCCTACACCTTCAGCAGCAAATCGCCCGGAAATGGGAGCTTGCGCGAA
GCGCTGATCGGCCCGCTGGGGAAGCTCATGGACCCGGGCTCCCTGCCGCCCCTCGACTCTGAAGATCTCTTCCAGGATCTAAGTCACTTC
CAGGAGACGTGGCTCGCTGAAGCTCAGGTACCAGACAGTGATGAGCAGTTTGTTCCTGATTTCCATTCAGAAAACCTAGCTTTCCACAGC
CCCACCACCAGGATCAAGAAGGAGCCCCAGAGTCCCCGCACAGACCCGGCCCTGTCCTGCAGCAGGAAGCCGCCACTCCCCTACCACCAT
GGCGAGCAGTGCCTTTACTCCAGTGCCTATGACCCCCCCAGACAAATCGCCATCAAGTCCCCTGCCCCTGGTGCCCTTGGACAGTCGCCC
CTACAGCCCTTTCCCCGGGCAGAGCAACGGAATTTCCTGAGATCCTCTGGCACCTCCCAGCCCCACCCTGGCCATGGGTACCTCGGGGAA
CATAGCTCCGTCTTCCAGCAGCCCCTGGACATTTGCCACTCCTTCACATCTCAGGGAGGGGGCCGGGAACCCCTCCCAGCCCCCTACCAA
CACCAGCTGTCGGAGCCCTGCCCACCCTATCCCCAGCAGAGCTTTAAGCAAGAATACCATGATCCCCTGTATGAACAGGCGGGCCAGCCA
GCCGTGGACCAGGGTGGGGTCAATGGGCACAGGTACCCAGGGGCGGGGGTGGTGATCAAACAGGAACAGACGGACTTCGCCTACGACTCA
GAAGTTCCTGAGTGGGTGAACACCCCATCCACCTGCTGCCTGAAGTATTATGAGAAAGTGTTGCCAAGGAGACTAGTGGTGGGATACAGA
AAGGCCCTCAACTGTCACCTGCCAGCAATCATCTTCGTCACCAAGAGGAACCGAGAAGTCTGCACCAACCCCAATGACGACTGGGTCCAA
GAGTACATCAAGGATCCCAACCTACCTTTGCTGCCTACCAGGAACTTGTCCACGGTTAAAATTATTACAGCAAAGAATGGTCAACCCCAG
CTCCTCAACTCCCAGTGATGACCAGGCTTTAGTGGAAGCCCTTGTTTACAGAAGAGAGGGGTAAACCTATGAAAACAGGGGAAGCCTTAT
TAGGCTGAAACTAGCCAGTCACATTGAGAGAAGCAGAACAATGATCAAAATAAAGGAGAAGTATTTCGAATATTTTCTCAATCTTAGGAG
GAAATACCAAAGTTAAGGGACGTGGGCAGAGGTACGCTCTTTTATTTTTATATTTATATTTTTATTTTTTTGAGATAGGGTCTTACTCTG
TCACCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTTGATCTTGGCTCACTGTAACCTCCACCTCCCAGGCTCAAGTGATCCTCCC
ACCCCAGCCTCCTGAGTAGCTGGGACTACAGGCTTGCGCCACCACACCTGGCTAATTTTTGTATTTTTGGTAGAGACGGGATTCTACCAT
GTTGCCCAGGCTGGTCTCAAACTCGTGTGCCCAAGCAATCCACCTGCCTCAGCCTTCCAAAAGTGCTGGGATTACAGGCGTGAGCCACCA
CATCCGGCCAGTGCACTCTTAATACACAGAAAAATATATTTCACATCCTTCTCCTGCTCTCTTTCAATTCCTCACTTCACACCAGTACAC
AAGCCATTCTAAATACTTAGCCAGTTTCCAGCCTTCCAGATGATCTTTGCCCTCTGGGTCTTGACCCATTAAGAGCCCCATAGAACTCTT
GATTTTTCCTGTCCATCTTTATGGATTTTTCTGGATCTATATTTTCTTCAATTATTCTTTCATTTTATAATGCAACTTTTTCATAGGAAG
TCCGGATGGGAATATTCACATTAATCATTTTTGCAGAGACTTTGCTAGATCCTCTCATATTTTGTCTTCCTCAGGGTGGCAGGGGTACAG
AGAGTGCCTGATTGGAAAAAAAAAAAAAAGAGAGAGAGAGAGAAGAAGAAGAAGAAGAGACACAAATCTCTACCTCCCATGTTAAGCTTT
GCAGGACAGGGAAAGAAAGGGTATGAGACACGGCTAGGGGTAAACTCTTAGTCCAAAACCCAAGCATGCAATAAATAAAACTCCCTTATT

>In-frame_ENST00000591713_ENST00000293275_TCGA-A2-A0T3-01A_ETV4_chr17_41610042_-_CCL16_chr17_34305299_length(amino acids)=365AA_start in transcript=90_stop in transcript=1187
MERRMKAGYLDQQVPYTFSSKSPGNGSLREALIGPLGKLMDPGSLPPLDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHS
PTTRIKKEPQSPRTDPALSCSRKPPLPYHHGEQCLYSSAYDPPRQIAIKSPAPGALGQSPLQPFPRAEQRNFLRSSGTSQPHPGHGYLGE
HSSVFQQPLDICHSFTSQGGGREPLPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQAGQPAVDQGGVNGHRYPGAGVVIKQEQTDFAYDS
EVPEWVNTPSTCCLKYYEKVLPRRLVVGYRKALNCHLPAIIFVTKRNREVCTNPNDDWVQEYIKDPNLPLLPTRNLSTVKIITAKNGQPQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ETV4-CCL16

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ETV4-CCL16

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ETV4-CCL16

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ETV4	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	ETV4	C0376358	Malignant neoplasm of prostate	2	CTD_human
Hgene	ETV4	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	ETV4	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	ETV4	C0678222	Breast Carcinoma	1	CTD_human
Hgene	ETV4	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	ETV4	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	ETV4	C4704874	Mammary Carcinoma, Human	1	CTD_human