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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:EXT2-PRMT10 (FusionGDB2 ID:27944) |
Fusion Gene Summary for EXT2-PRMT10 |
Fusion gene summary |
Fusion gene information | Fusion gene name: EXT2-PRMT10 | Fusion gene ID: 27944 | Hgene | Tgene | Gene symbol | EXT2 | PRMT10 | Gene ID | 2132 | 90826 |
Gene name | exostosin glycosyltransferase 2 | protein arginine methyltransferase 9 | |
Synonyms | SOTV|SSMS | PRMT10 | |
Cytomap | 11p11.2 | 4q31.23 | |
Type of gene | protein-coding | protein-coding | |
Description | exostosin-2N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferaseglucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferasemultiple exostoses protein 2multiple exostosis 2putativ | protein arginine N-methyltransferase 9protein arginine N-methyltransferase 10protein arginine methyltransferase 10 (putative)putative protein arginine N-methyltransferase 10putative protein arginine N-methyltransferase 9 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000533608, ENST00000358681, ENST00000395673, ENST00000343631, ENST00000529186, | ENST00000322396, ENST00000541232, | |
Fusion gene scores | * DoF score | 8 X 6 X 8=384 | 2 X 2 X 2=8 |
# samples | 9 | 2 | |
** MAII score | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: EXT2 [Title/Abstract] AND PRMT10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | EXT2(44151688)-PRMT10(148601622), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EXT2 | GO:0006024 | glycosaminoglycan biosynthetic process | 12907669 |
Hgene | EXT2 | GO:0033692 | cellular polysaccharide biosynthetic process | 12907669 |
Fusion gene breakpoints across EXT2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across PRMT10 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUSC | TCGA-85-8354 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
ChimerDB4 | LUSC | TCGA-85-8354-01A | EXT2 | chr11 | 44151688 | - | PRMT10 | chr4 | 148601622 | - |
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Fusion Gene ORF analysis for EXT2-PRMT10 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000533608 | ENST00000322396 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
5CDS-intron | ENST00000533608 | ENST00000541232 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
In-frame | ENST00000358681 | ENST00000322396 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
5CDS-intron | ENST00000358681 | ENST00000541232 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
In-frame | ENST00000395673 | ENST00000322396 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
5CDS-intron | ENST00000395673 | ENST00000541232 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
In-frame | ENST00000343631 | ENST00000322396 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
5CDS-intron | ENST00000343631 | ENST00000541232 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
intron-3CDS | ENST00000529186 | ENST00000322396 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
intron-intron | ENST00000529186 | ENST00000541232 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000533608 | EXT2 | chr11 | 44151688 | + | ENST00000322396 | PRMT10 | chr4 | 148601622 | - | 4603 | 1507 | 4 | 3855 | 1283 |
ENST00000358681 | EXT2 | chr11 | 44151688 | + | ENST00000322396 | PRMT10 | chr4 | 148601622 | - | 4435 | 1339 | 34 | 3687 | 1217 |
ENST00000395673 | EXT2 | chr11 | 44151688 | + | ENST00000322396 | PRMT10 | chr4 | 148601622 | - | 4424 | 1328 | 38 | 3676 | 1212 |
ENST00000343631 | EXT2 | chr11 | 44151688 | + | ENST00000322396 | PRMT10 | chr4 | 148601622 | - | 4398 | 1302 | 12 | 3650 | 1212 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000533608 | ENST00000322396 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - | 0.000355332 | 0.99964464 |
ENST00000358681 | ENST00000322396 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - | 0.000268386 | 0.9997316 |
ENST00000395673 | ENST00000322396 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - | 0.000225762 | 0.9997743 |
ENST00000343631 | ENST00000322396 | EXT2 | chr11 | 44151688 | + | PRMT10 | chr4 | 148601622 | - | 0.000216544 | 0.99978346 |
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Fusion Genomic Features for EXT2-PRMT10 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for EXT2-PRMT10 |
Go to FGviewer for the breakpoints of chr11:44151688-chr4:148601622 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000343631 | + | 7 | 14 | 1_25 | 391.0 | 719.0 | Topological domain | Cytoplasmic |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000358681 | + | 7 | 15 | 1_25 | 391.0 | 729.0 | Topological domain | Cytoplasmic |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000395673 | + | 7 | 14 | 1_25 | 424.0 | 752.0 | Topological domain | Cytoplasmic |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000533608 | + | 7 | 14 | 1_25 | 391.0 | 719.0 | Topological domain | Cytoplasmic |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000343631 | + | 7 | 14 | 26_46 | 391.0 | 719.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000358681 | + | 7 | 15 | 26_46 | 391.0 | 729.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000395673 | + | 7 | 14 | 26_46 | 424.0 | 752.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000533608 | + | 7 | 14 | 26_46 | 391.0 | 719.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Tgene | PRMT10 | chr11:44151688 | chr4:148601622 | ENST00000322396 | 0 | 12 | 137_466 | 63.0 | 846.0 | Domain | SAM-dependent MTase PRMT-type 1 | |
Tgene | PRMT10 | chr11:44151688 | chr4:148601622 | ENST00000322396 | 0 | 12 | 530_845 | 63.0 | 846.0 | Domain | SAM-dependent MTase PRMT-type 2 | |
Tgene | PRMT10 | chr11:44151688 | chr4:148601622 | ENST00000322396 | 0 | 12 | 101_134 | 63.0 | 846.0 | Repeat | Note=TPR 3 | |
Tgene | PRMT10 | chr11:44151688 | chr4:148601622 | ENST00000322396 | 0 | 12 | 67_100 | 63.0 | 846.0 | Repeat | Note=TPR 2 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000343631 | + | 7 | 14 | 517_522 | 391.0 | 719.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000343631 | + | 7 | 14 | 538_540 | 391.0 | 719.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000343631 | + | 7 | 14 | 624_628 | 391.0 | 719.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000343631 | + | 7 | 14 | 662_673 | 391.0 | 719.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000358681 | + | 7 | 15 | 517_522 | 391.0 | 729.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000358681 | + | 7 | 15 | 538_540 | 391.0 | 729.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000358681 | + | 7 | 15 | 624_628 | 391.0 | 729.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000358681 | + | 7 | 15 | 662_673 | 391.0 | 729.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000395673 | + | 7 | 14 | 517_522 | 424.0 | 752.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000395673 | + | 7 | 14 | 538_540 | 424.0 | 752.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000395673 | + | 7 | 14 | 624_628 | 424.0 | 752.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000395673 | + | 7 | 14 | 662_673 | 424.0 | 752.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000533608 | + | 7 | 14 | 517_522 | 391.0 | 719.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000533608 | + | 7 | 14 | 538_540 | 391.0 | 719.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000533608 | + | 7 | 14 | 624_628 | 391.0 | 719.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000533608 | + | 7 | 14 | 662_673 | 391.0 | 719.0 | Region | Substrate binding |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000343631 | + | 7 | 14 | 47_718 | 391.0 | 719.0 | Topological domain | Lumenal |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000358681 | + | 7 | 15 | 47_718 | 391.0 | 729.0 | Topological domain | Lumenal |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000395673 | + | 7 | 14 | 47_718 | 424.0 | 752.0 | Topological domain | Lumenal |
Hgene | EXT2 | chr11:44151688 | chr4:148601622 | ENST00000533608 | + | 7 | 14 | 47_718 | 391.0 | 719.0 | Topological domain | Lumenal |
Tgene | PRMT10 | chr11:44151688 | chr4:148601622 | ENST00000322396 | 0 | 12 | 25_58 | 63.0 | 846.0 | Repeat | Note=TPR 1 |
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Fusion Gene Sequence for EXT2-PRMT10 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000533608_ENST00000322396_TCGA-85-8354_EXT2_chr11_44151688_+_PRMT10_chr4_148601622_length(transcript)=4603nt_BP=1507nt CTGTCTGAGCATTTCACTGCGGAGCCTGAGCGCGCCTGCCTGGGAAAACACTGCAGCGGTGCTCGGACTCCTCCTGTCCAGCAGGAGGCG CGGCCCGGCAGCTCCCGCATGCGCAGTGCGCTCGGTGTCAGACGGCCCGGATCCCGGTTACCGGCCCCTCGCTCGCTGCTCGCCAGCCCA GACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGAGCCGGTGACCAA GCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATAT CCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGC CACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGT TAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAA CCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGA GTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGT GCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTT CAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTAC GTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCC ACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTC AGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCC ACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTG TGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAA GATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGGAAACTTTTCAGTACACACTTTT CAGATGGGCTGAAGAGCTTGATGCTCTCAGTCGGATACAAGACTTACTTGGTTGCTATGAGCAGGCCTTGGAACTGTTTCCTGATGATGA AGTGATTTGCAATAGTATGGGGGAGCATCTCTTCAGAATGGGCTTTAGGGATGAAGCAGCTGGGTATTTTCATAAAGCAGTGAAGCTAAA CCCTGATTTCAGTGATGCAAAGGAGAATTTTTATCGTGTTGCAAACTGGTTGGTGGAACGCTGGCACTTTATCATGCTTAATGACACCAA GAGGAATACAATTTATAATGCAGCAATCCAAAAGGCAGTTTGTTTGGGGTCCAAAAGTGTTTTGGACATTGGAGCAGGAACTGGAATACT AAGCATGTTTGCTAAAAAAGCTGGAGCACATTCCGTGTATGCCTGTGAGTTATCCAAGACCATGTATGAACTTGCCTGTGATGTCGTGGC AGCAAACAAGATGGAAGCAGGGATCAAACTCTTACATACGAAGTCACTTGACATAGAGATTCCAAAACATATTCCCGAAAGAGTGTCCCT AGTTGTAACAGAAACTGTCGATGCAGGTTTATTTGGAGAAGGAATTGTGGAGAGTTTGATTCATGCATGGGAGCATTTACTTTTACAGCC AAAGACCAAAGGTGAAAGTGCTAATTGTGAAAAGTATGGGAAAGTTATACCAGCAAGTGCTGTTATATTTGGGATGGCAGTAGAATGTGC AGAGATAAGAAGACATCATAGAGTGGGTATTAAGGACATTGCTGGTATCCATTTGCCAACAAATGTGAAATTTCAGAGTCCGGCTTATTC TTCTGTAGATACTGAAGAAACAATTGAACCTTATACAACTGAAAAGATGAGTCGAGTTCCTGGAGGATATTTGGCTTTGACAGAGTGCTT TGAAATTATGACAGTAGATTTCAACAACCTTCAGGAATTAAAAAGTCTTGCAACTAAAAAGCCTGATAAGATTGGTATTCCTGTTATTAA AGAAGGCATACTAGATGCTATTATGGTTTGGTTTGTGCTCCAGCTTGATGATGAACATAGTTTATCCACAAGTCCTAGTGAGGAAACATG TTGGGAACAGGCTGTCTACCCCGTACAGGACCTTGCAGACTACTGGATAAAGCCTGGAGACCATGTGATGATGGAAGTATCTTGTCAAGA CTGTTACTTAAGAATCCAGAGTATTAGTGTCTTGGGTTTGGAATGTGAAATGGATGTTGCAAAAAGTTTTACCCAGAATAAAGACTTGTT ATCGTTAGGAAATGAGGCTGAACTTTGTAGTGCCCTCGCTAACCTTCAGACCAGTAAACCAGATGCTGTAGAGCAGACATGTATATTGGA ATCTACAGAAATTGCTTTGCTTAACAACATCCCATATCATGAAGGCTTTAAAATGGCAATGAGCAAAGTTTTGTCTTCACTGACTCCAGA GAAACTGTATCAGACCATGGATACTCACTGTCAGAATGAGATGAGCTCTGGAACTGGACAGAGTAATACTGTACAGAACATCCTTGAACC TTTCTACGTGTTAGATGTGTCCGAAGGCTTCTCTGTTCTGCCTGTTATTGCTGGCACACTTGGGCAGGTTAAACCATACAGTTCTGTGGA GAAAGACCAGCATCGTATTGCTCTGGACCTCATATCTGAAGCCAATCACTTTCCTAAAGAAACACTTGAGTTTTGGCTGAGACATGTGGA GGATGAATCTGCTATGTTACAAAGGCCAAAATCAGACAAGTTATGGAGCATAATTATATTGGATGTCATTGAGCCATCTGGGCTCATTCA GCAGGAAATAATGGAAAAAGCTGCAATATCCAGGTGTTTACTACAATCTGGAGGCAAGATCTTTCCTCAGTATGTGCTGATGTTTGGGTT GCTTGTGGAATCACAGACACTCCTAGAGGAGAATGCTGTTCAAGGAACAGAACGTACTCTTGGATTAAATATAGCACCTTTTATTAACCA GTTTCAGGTACCTATACGTGTATTTTTGGACCTATCCTCATTGCCCTGTATACCTTTAAGCAAGCCAGTGGAACTCTTAAGACTAGATTT AATGACTCCGTATTTGAACACCTCTAACAGAGAAGTAAAGGTATACGTTTGTAAATCTGGAAGACTGACTGCTATTCCATTTTGGTATCA TATGTACCTTGATGAAGAGATTAGGTTGGATACTTCAAGTGAAGCCTCCCACTGGAAACAAGCTGCAGTTGTTTTAGATAATCCCATCCA GGTTGAAATGGGAGAGGAACTTGTACTCAGCATTCAGCATCACAAAAGCAATGTCAGCATCACAGTAAAGCAATGAAGAGCAGTTTTCCA ATGAAAACTGTGTAAATAGAGCATCAACAAGTACAAAATTCTTGTCTTAATTAGTGGGGGTATATAAAAATTCCTTGTAATGGTCAAATA TTTTTTAAAATTGACATTAATAAAGCATATTTTAAAAGATTCTAAATAAAAGGGTAGCATTATTATAGAAATACTGCTGCAGATTTGCTT TCTGGAAAAGGATACATCACTAGTTTTTTAAATTAGGAAACTTCTTTTGCTCGATTTTACAGAATAGGGATTTTAAAAGTCTTATCGTTA TTGACATGTGTAAGTAAAGCAAAACTTTACTTTTGTAGGCATCTTGGCCTTTTTTCTTAAATCCAAACTTGTAATTGGGAAACACTGAAA GGCTTCCACTGAAGACTGAGGGTTATGGTTACCTGTAAATTCCAATCTTGCTTCCTTTAAATACTCAGTGTACATCTGAAACATCTCAGG TTTTGTTTTGAGAATGCAAGCTTGAAAAAGAATTTAAGCTATAAGCTAAATGTAATTAAAACAGTAAAGGAGTTAGGGAATACATCTTCA GGAGGCAGCATTTTTCTTGGTCTACTTTGGCAAAAGAACATTTAAAAGCTGGTAACAAAACAAAGTTAAATTGAAGGAAGACTTAATCCT ATACTATTTTTCAAAGTTTTGATTTGGATGTACAATAAGTACATTAATTGATCCAATTTTTACAAACTTTTGAAATAAAGGAAGATCATT >In-frame_ENST00000533608_ENST00000322396_TCGA-85-8354_EXT2_chr11_44151688_+_PRMT10_chr4_148601622_length(amino acids)=1283AA_start in transcript=4_stop in transcript=3855 MSISLRSLSAPAWENTAAVLGLLLSSRRRGPAAPACAVRSVSDGPDPGYRPLARCSPAQTRPWQWRLAIRTDPTWAEVARAPRHEPVTKL GAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVR LPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVL NQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPR QYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCV PVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQETFQYTLFRWAEELDALSRIQDLLGCYEQALELFPDDEV ICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKAVCLGSKSVLDIGAGTGILS MFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLLQPK TKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYTTEKMSRVPGGYLALTECFE IMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLADYWIKPGDHVMMEVSCQDC YLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPYHEGFKMAMSKVLSSLTPEK LYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLISEANHFPKETLEFWLRHVED ESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENAVQGTERTLGLNIAPFINQF QVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEIRLDTSSEASHWKQAAVVLDNPIQV -------------------------------------------------------------- >In-frame_ENST00000358681_ENST00000322396_TCGA-85-8354_EXT2_chr11_44151688_+_PRMT10_chr4_148601622_length(transcript)=4435nt_BP=1339nt CTCGCCAGCCCAGACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGA GCCGGTGACCAAGCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGT CAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCT GGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGA TGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCG CTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACAC CATCTCCCGGGAGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCC CTCCATCGATGTGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAA TCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGG CGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAA AGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAA ACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGT CTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTT ACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGT ACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGGAAACTTTTCA GTACACACTTTTCAGATGGGCTGAAGAGCTTGATGCTCTCAGTCGGATACAAGACTTACTTGGTTGCTATGAGCAGGCCTTGGAACTGTT TCCTGATGATGAAGTGATTTGCAATAGTATGGGGGAGCATCTCTTCAGAATGGGCTTTAGGGATGAAGCAGCTGGGTATTTTCATAAAGC AGTGAAGCTAAACCCTGATTTCAGTGATGCAAAGGAGAATTTTTATCGTGTTGCAAACTGGTTGGTGGAACGCTGGCACTTTATCATGCT TAATGACACCAAGAGGAATACAATTTATAATGCAGCAATCCAAAAGGCAGTTTGTTTGGGGTCCAAAAGTGTTTTGGACATTGGAGCAGG AACTGGAATACTAAGCATGTTTGCTAAAAAAGCTGGAGCACATTCCGTGTATGCCTGTGAGTTATCCAAGACCATGTATGAACTTGCCTG TGATGTCGTGGCAGCAAACAAGATGGAAGCAGGGATCAAACTCTTACATACGAAGTCACTTGACATAGAGATTCCAAAACATATTCCCGA AAGAGTGTCCCTAGTTGTAACAGAAACTGTCGATGCAGGTTTATTTGGAGAAGGAATTGTGGAGAGTTTGATTCATGCATGGGAGCATTT ACTTTTACAGCCAAAGACCAAAGGTGAAAGTGCTAATTGTGAAAAGTATGGGAAAGTTATACCAGCAAGTGCTGTTATATTTGGGATGGC AGTAGAATGTGCAGAGATAAGAAGACATCATAGAGTGGGTATTAAGGACATTGCTGGTATCCATTTGCCAACAAATGTGAAATTTCAGAG TCCGGCTTATTCTTCTGTAGATACTGAAGAAACAATTGAACCTTATACAACTGAAAAGATGAGTCGAGTTCCTGGAGGATATTTGGCTTT GACAGAGTGCTTTGAAATTATGACAGTAGATTTCAACAACCTTCAGGAATTAAAAAGTCTTGCAACTAAAAAGCCTGATAAGATTGGTAT TCCTGTTATTAAAGAAGGCATACTAGATGCTATTATGGTTTGGTTTGTGCTCCAGCTTGATGATGAACATAGTTTATCCACAAGTCCTAG TGAGGAAACATGTTGGGAACAGGCTGTCTACCCCGTACAGGACCTTGCAGACTACTGGATAAAGCCTGGAGACCATGTGATGATGGAAGT ATCTTGTCAAGACTGTTACTTAAGAATCCAGAGTATTAGTGTCTTGGGTTTGGAATGTGAAATGGATGTTGCAAAAAGTTTTACCCAGAA TAAAGACTTGTTATCGTTAGGAAATGAGGCTGAACTTTGTAGTGCCCTCGCTAACCTTCAGACCAGTAAACCAGATGCTGTAGAGCAGAC ATGTATATTGGAATCTACAGAAATTGCTTTGCTTAACAACATCCCATATCATGAAGGCTTTAAAATGGCAATGAGCAAAGTTTTGTCTTC ACTGACTCCAGAGAAACTGTATCAGACCATGGATACTCACTGTCAGAATGAGATGAGCTCTGGAACTGGACAGAGTAATACTGTACAGAA CATCCTTGAACCTTTCTACGTGTTAGATGTGTCCGAAGGCTTCTCTGTTCTGCCTGTTATTGCTGGCACACTTGGGCAGGTTAAACCATA CAGTTCTGTGGAGAAAGACCAGCATCGTATTGCTCTGGACCTCATATCTGAAGCCAATCACTTTCCTAAAGAAACACTTGAGTTTTGGCT GAGACATGTGGAGGATGAATCTGCTATGTTACAAAGGCCAAAATCAGACAAGTTATGGAGCATAATTATATTGGATGTCATTGAGCCATC TGGGCTCATTCAGCAGGAAATAATGGAAAAAGCTGCAATATCCAGGTGTTTACTACAATCTGGAGGCAAGATCTTTCCTCAGTATGTGCT GATGTTTGGGTTGCTTGTGGAATCACAGACACTCCTAGAGGAGAATGCTGTTCAAGGAACAGAACGTACTCTTGGATTAAATATAGCACC TTTTATTAACCAGTTTCAGGTACCTATACGTGTATTTTTGGACCTATCCTCATTGCCCTGTATACCTTTAAGCAAGCCAGTGGAACTCTT AAGACTAGATTTAATGACTCCGTATTTGAACACCTCTAACAGAGAAGTAAAGGTATACGTTTGTAAATCTGGAAGACTGACTGCTATTCC ATTTTGGTATCATATGTACCTTGATGAAGAGATTAGGTTGGATACTTCAAGTGAAGCCTCCCACTGGAAACAAGCTGCAGTTGTTTTAGA TAATCCCATCCAGGTTGAAATGGGAGAGGAACTTGTACTCAGCATTCAGCATCACAAAAGCAATGTCAGCATCACAGTAAAGCAATGAAG AGCAGTTTTCCAATGAAAACTGTGTAAATAGAGCATCAACAAGTACAAAATTCTTGTCTTAATTAGTGGGGGTATATAAAAATTCCTTGT AATGGTCAAATATTTTTTAAAATTGACATTAATAAAGCATATTTTAAAAGATTCTAAATAAAAGGGTAGCATTATTATAGAAATACTGCT GCAGATTTGCTTTCTGGAAAAGGATACATCACTAGTTTTTTAAATTAGGAAACTTCTTTTGCTCGATTTTACAGAATAGGGATTTTAAAA GTCTTATCGTTATTGACATGTGTAAGTAAAGCAAAACTTTACTTTTGTAGGCATCTTGGCCTTTTTTCTTAAATCCAAACTTGTAATTGG GAAACACTGAAAGGCTTCCACTGAAGACTGAGGGTTATGGTTACCTGTAAATTCCAATCTTGCTTCCTTTAAATACTCAGTGTACATCTG AAACATCTCAGGTTTTGTTTTGAGAATGCAAGCTTGAAAAAGAATTTAAGCTATAAGCTAAATGTAATTAAAACAGTAAAGGAGTTAGGG AATACATCTTCAGGAGGCAGCATTTTTCTTGGTCTACTTTGGCAAAAGAACATTTAAAAGCTGGTAACAAAACAAAGTTAAATTGAAGGA AGACTTAATCCTATACTATTTTTCAAAGTTTTGATTTGGATGTACAATAAGTACATTAATTGATCCAATTTTTACAAACTTTTGAAATAA >In-frame_ENST00000358681_ENST00000322396_TCGA-85-8354_EXT2_chr11_44151688_+_PRMT10_chr4_148601622_length(amino acids)=1217AA_start in transcript=34_stop in transcript=3687 MAIRTDPTWAEVARAPRHEPVTKLGAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFW PHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMA ISDSDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGY DVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEAT FCVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQETFQYTLFRWAEELD ALSRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNA AIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVD AGLFGEGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEET IEPYTTEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYP VQDLADYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALL NNIPYHEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIA LDLISEANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTL LEENAVQGTERTLGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEI -------------------------------------------------------------- >In-frame_ENST00000395673_ENST00000322396_TCGA-85-8354_EXT2_chr11_44151688_+_PRMT10_chr4_148601622_length(transcript)=4424nt_BP=1328nt TCCCTTCCTGCTGCCACCTTCCCGCCAGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGC GGCATCCCTTGCGGTGCCAGAAGCCGTGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATA TCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTG CCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTG TTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCA ACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGG AGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATG TGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGT TCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTA CGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTC CACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGT CAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACC CACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCT GTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAA AGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGGAAACTTTTCAGTACACACTTT TCAGATGGGCTGAAGAGCTTGATGCTCTCAGTCGGATACAAGACTTACTTGGTTGCTATGAGCAGGCCTTGGAACTGTTTCCTGATGATG AAGTGATTTGCAATAGTATGGGGGAGCATCTCTTCAGAATGGGCTTTAGGGATGAAGCAGCTGGGTATTTTCATAAAGCAGTGAAGCTAA ACCCTGATTTCAGTGATGCAAAGGAGAATTTTTATCGTGTTGCAAACTGGTTGGTGGAACGCTGGCACTTTATCATGCTTAATGACACCA AGAGGAATACAATTTATAATGCAGCAATCCAAAAGGCAGTTTGTTTGGGGTCCAAAAGTGTTTTGGACATTGGAGCAGGAACTGGAATAC TAAGCATGTTTGCTAAAAAAGCTGGAGCACATTCCGTGTATGCCTGTGAGTTATCCAAGACCATGTATGAACTTGCCTGTGATGTCGTGG CAGCAAACAAGATGGAAGCAGGGATCAAACTCTTACATACGAAGTCACTTGACATAGAGATTCCAAAACATATTCCCGAAAGAGTGTCCC TAGTTGTAACAGAAACTGTCGATGCAGGTTTATTTGGAGAAGGAATTGTGGAGAGTTTGATTCATGCATGGGAGCATTTACTTTTACAGC CAAAGACCAAAGGTGAAAGTGCTAATTGTGAAAAGTATGGGAAAGTTATACCAGCAAGTGCTGTTATATTTGGGATGGCAGTAGAATGTG CAGAGATAAGAAGACATCATAGAGTGGGTATTAAGGACATTGCTGGTATCCATTTGCCAACAAATGTGAAATTTCAGAGTCCGGCTTATT CTTCTGTAGATACTGAAGAAACAATTGAACCTTATACAACTGAAAAGATGAGTCGAGTTCCTGGAGGATATTTGGCTTTGACAGAGTGCT TTGAAATTATGACAGTAGATTTCAACAACCTTCAGGAATTAAAAAGTCTTGCAACTAAAAAGCCTGATAAGATTGGTATTCCTGTTATTA AAGAAGGCATACTAGATGCTATTATGGTTTGGTTTGTGCTCCAGCTTGATGATGAACATAGTTTATCCACAAGTCCTAGTGAGGAAACAT GTTGGGAACAGGCTGTCTACCCCGTACAGGACCTTGCAGACTACTGGATAAAGCCTGGAGACCATGTGATGATGGAAGTATCTTGTCAAG ACTGTTACTTAAGAATCCAGAGTATTAGTGTCTTGGGTTTGGAATGTGAAATGGATGTTGCAAAAAGTTTTACCCAGAATAAAGACTTGT TATCGTTAGGAAATGAGGCTGAACTTTGTAGTGCCCTCGCTAACCTTCAGACCAGTAAACCAGATGCTGTAGAGCAGACATGTATATTGG AATCTACAGAAATTGCTTTGCTTAACAACATCCCATATCATGAAGGCTTTAAAATGGCAATGAGCAAAGTTTTGTCTTCACTGACTCCAG AGAAACTGTATCAGACCATGGATACTCACTGTCAGAATGAGATGAGCTCTGGAACTGGACAGAGTAATACTGTACAGAACATCCTTGAAC CTTTCTACGTGTTAGATGTGTCCGAAGGCTTCTCTGTTCTGCCTGTTATTGCTGGCACACTTGGGCAGGTTAAACCATACAGTTCTGTGG AGAAAGACCAGCATCGTATTGCTCTGGACCTCATATCTGAAGCCAATCACTTTCCTAAAGAAACACTTGAGTTTTGGCTGAGACATGTGG AGGATGAATCTGCTATGTTACAAAGGCCAAAATCAGACAAGTTATGGAGCATAATTATATTGGATGTCATTGAGCCATCTGGGCTCATTC AGCAGGAAATAATGGAAAAAGCTGCAATATCCAGGTGTTTACTACAATCTGGAGGCAAGATCTTTCCTCAGTATGTGCTGATGTTTGGGT TGCTTGTGGAATCACAGACACTCCTAGAGGAGAATGCTGTTCAAGGAACAGAACGTACTCTTGGATTAAATATAGCACCTTTTATTAACC AGTTTCAGGTACCTATACGTGTATTTTTGGACCTATCCTCATTGCCCTGTATACCTTTAAGCAAGCCAGTGGAACTCTTAAGACTAGATT TAATGACTCCGTATTTGAACACCTCTAACAGAGAAGTAAAGGTATACGTTTGTAAATCTGGAAGACTGACTGCTATTCCATTTTGGTATC ATATGTACCTTGATGAAGAGATTAGGTTGGATACTTCAAGTGAAGCCTCCCACTGGAAACAAGCTGCAGTTGTTTTAGATAATCCCATCC AGGTTGAAATGGGAGAGGAACTTGTACTCAGCATTCAGCATCACAAAAGCAATGTCAGCATCACAGTAAAGCAATGAAGAGCAGTTTTCC AATGAAAACTGTGTAAATAGAGCATCAACAAGTACAAAATTCTTGTCTTAATTAGTGGGGGTATATAAAAATTCCTTGTAATGGTCAAAT ATTTTTTAAAATTGACATTAATAAAGCATATTTTAAAAGATTCTAAATAAAAGGGTAGCATTATTATAGAAATACTGCTGCAGATTTGCT TTCTGGAAAAGGATACATCACTAGTTTTTTAAATTAGGAAACTTCTTTTGCTCGATTTTACAGAATAGGGATTTTAAAAGTCTTATCGTT ATTGACATGTGTAAGTAAAGCAAAACTTTACTTTTGTAGGCATCTTGGCCTTTTTTCTTAAATCCAAACTTGTAATTGGGAAACACTGAA AGGCTTCCACTGAAGACTGAGGGTTATGGTTACCTGTAAATTCCAATCTTGCTTCCTTTAAATACTCAGTGTACATCTGAAACATCTCAG GTTTTGTTTTGAGAATGCAAGCTTGAAAAAGAATTTAAGCTATAAGCTAAATGTAATTAAAACAGTAAAGGAGTTAGGGAATACATCTTC AGGAGGCAGCATTTTTCTTGGTCTACTTTGGCAAAAGAACATTTAAAAGCTGGTAACAAAACAAAGTTAAATTGAAGGAAGACTTAATCC TATACTATTTTTCAAAGTTTTGATTTGGATGTACAATAAGTACATTAATTGATCCAATTTTTACAAACTTTTGAAATAAAGGAAGATCAT >In-frame_ENST00000395673_ENST00000322396_TCGA-85-8354_EXT2_chr11_44151688_+_PRMT10_chr4_148601622_length(amino acids)=1212AA_start in transcript=38_stop in transcript=3676 MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQETFQYTLFRWAEELDALSRI QDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKA VCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFG EGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYT TEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLA DYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPY HEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLIS EANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENA VQGTERTLGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEIRLDTS -------------------------------------------------------------- >In-frame_ENST00000343631_ENST00000322396_TCGA-85-8354_EXT2_chr11_44151688_+_PRMT10_chr4_148601622_length(transcript)=4398nt_BP=1302nt AGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGCGGCATCCCTTGCGGTGCCAGAAGCCG TGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGA ATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCC CATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATC CCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTAT ATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGAGTATAATGAACTGCTCATGGCCATC TCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGTGCTTAACCAGAACACACTGCGCATC AAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCA GATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGAT GTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCT CAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACC AACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTC TGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCC TATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTG CAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGGAAACTTTTCAGTACACACTTTTCAGATGGGCTGAAGAGCTTGATGCT CTCAGTCGGATACAAGACTTACTTGGTTGCTATGAGCAGGCCTTGGAACTGTTTCCTGATGATGAAGTGATTTGCAATAGTATGGGGGAG CATCTCTTCAGAATGGGCTTTAGGGATGAAGCAGCTGGGTATTTTCATAAAGCAGTGAAGCTAAACCCTGATTTCAGTGATGCAAAGGAG AATTTTTATCGTGTTGCAAACTGGTTGGTGGAACGCTGGCACTTTATCATGCTTAATGACACCAAGAGGAATACAATTTATAATGCAGCA ATCCAAAAGGCAGTTTGTTTGGGGTCCAAAAGTGTTTTGGACATTGGAGCAGGAACTGGAATACTAAGCATGTTTGCTAAAAAAGCTGGA GCACATTCCGTGTATGCCTGTGAGTTATCCAAGACCATGTATGAACTTGCCTGTGATGTCGTGGCAGCAAACAAGATGGAAGCAGGGATC AAACTCTTACATACGAAGTCACTTGACATAGAGATTCCAAAACATATTCCCGAAAGAGTGTCCCTAGTTGTAACAGAAACTGTCGATGCA GGTTTATTTGGAGAAGGAATTGTGGAGAGTTTGATTCATGCATGGGAGCATTTACTTTTACAGCCAAAGACCAAAGGTGAAAGTGCTAAT TGTGAAAAGTATGGGAAAGTTATACCAGCAAGTGCTGTTATATTTGGGATGGCAGTAGAATGTGCAGAGATAAGAAGACATCATAGAGTG GGTATTAAGGACATTGCTGGTATCCATTTGCCAACAAATGTGAAATTTCAGAGTCCGGCTTATTCTTCTGTAGATACTGAAGAAACAATT GAACCTTATACAACTGAAAAGATGAGTCGAGTTCCTGGAGGATATTTGGCTTTGACAGAGTGCTTTGAAATTATGACAGTAGATTTCAAC AACCTTCAGGAATTAAAAAGTCTTGCAACTAAAAAGCCTGATAAGATTGGTATTCCTGTTATTAAAGAAGGCATACTAGATGCTATTATG GTTTGGTTTGTGCTCCAGCTTGATGATGAACATAGTTTATCCACAAGTCCTAGTGAGGAAACATGTTGGGAACAGGCTGTCTACCCCGTA CAGGACCTTGCAGACTACTGGATAAAGCCTGGAGACCATGTGATGATGGAAGTATCTTGTCAAGACTGTTACTTAAGAATCCAGAGTATT AGTGTCTTGGGTTTGGAATGTGAAATGGATGTTGCAAAAAGTTTTACCCAGAATAAAGACTTGTTATCGTTAGGAAATGAGGCTGAACTT TGTAGTGCCCTCGCTAACCTTCAGACCAGTAAACCAGATGCTGTAGAGCAGACATGTATATTGGAATCTACAGAAATTGCTTTGCTTAAC AACATCCCATATCATGAAGGCTTTAAAATGGCAATGAGCAAAGTTTTGTCTTCACTGACTCCAGAGAAACTGTATCAGACCATGGATACT CACTGTCAGAATGAGATGAGCTCTGGAACTGGACAGAGTAATACTGTACAGAACATCCTTGAACCTTTCTACGTGTTAGATGTGTCCGAA GGCTTCTCTGTTCTGCCTGTTATTGCTGGCACACTTGGGCAGGTTAAACCATACAGTTCTGTGGAGAAAGACCAGCATCGTATTGCTCTG GACCTCATATCTGAAGCCAATCACTTTCCTAAAGAAACACTTGAGTTTTGGCTGAGACATGTGGAGGATGAATCTGCTATGTTACAAAGG CCAAAATCAGACAAGTTATGGAGCATAATTATATTGGATGTCATTGAGCCATCTGGGCTCATTCAGCAGGAAATAATGGAAAAAGCTGCA ATATCCAGGTGTTTACTACAATCTGGAGGCAAGATCTTTCCTCAGTATGTGCTGATGTTTGGGTTGCTTGTGGAATCACAGACACTCCTA GAGGAGAATGCTGTTCAAGGAACAGAACGTACTCTTGGATTAAATATAGCACCTTTTATTAACCAGTTTCAGGTACCTATACGTGTATTT TTGGACCTATCCTCATTGCCCTGTATACCTTTAAGCAAGCCAGTGGAACTCTTAAGACTAGATTTAATGACTCCGTATTTGAACACCTCT AACAGAGAAGTAAAGGTATACGTTTGTAAATCTGGAAGACTGACTGCTATTCCATTTTGGTATCATATGTACCTTGATGAAGAGATTAGG TTGGATACTTCAAGTGAAGCCTCCCACTGGAAACAAGCTGCAGTTGTTTTAGATAATCCCATCCAGGTTGAAATGGGAGAGGAACTTGTA CTCAGCATTCAGCATCACAAAAGCAATGTCAGCATCACAGTAAAGCAATGAAGAGCAGTTTTCCAATGAAAACTGTGTAAATAGAGCATC AACAAGTACAAAATTCTTGTCTTAATTAGTGGGGGTATATAAAAATTCCTTGTAATGGTCAAATATTTTTTAAAATTGACATTAATAAAG CATATTTTAAAAGATTCTAAATAAAAGGGTAGCATTATTATAGAAATACTGCTGCAGATTTGCTTTCTGGAAAAGGATACATCACTAGTT TTTTAAATTAGGAAACTTCTTTTGCTCGATTTTACAGAATAGGGATTTTAAAAGTCTTATCGTTATTGACATGTGTAAGTAAAGCAAAAC TTTACTTTTGTAGGCATCTTGGCCTTTTTTCTTAAATCCAAACTTGTAATTGGGAAACACTGAAAGGCTTCCACTGAAGACTGAGGGTTA TGGTTACCTGTAAATTCCAATCTTGCTTCCTTTAAATACTCAGTGTACATCTGAAACATCTCAGGTTTTGTTTTGAGAATGCAAGCTTGA AAAAGAATTTAAGCTATAAGCTAAATGTAATTAAAACAGTAAAGGAGTTAGGGAATACATCTTCAGGAGGCAGCATTTTTCTTGGTCTAC TTTGGCAAAAGAACATTTAAAAGCTGGTAACAAAACAAAGTTAAATTGAAGGAAGACTTAATCCTATACTATTTTTCAAAGTTTTGATTT >In-frame_ENST00000343631_ENST00000322396_TCGA-85-8354_EXT2_chr11_44151688_+_PRMT10_chr4_148601622_length(amino acids)=1212AA_start in transcript=12_stop in transcript=3650 MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQETFQYTLFRWAEELDALSRI QDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKA VCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFG EGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYT TEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLA DYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPY HEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLIS EANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENA VQGTERTLGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEIRLDTS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for EXT2-PRMT10 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EXT2-PRMT10 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EXT2-PRMT10 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EXT2 | C1851413 | EXOSTOSES, MULTIPLE, TYPE II | 18 | CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | EXT2 | C4225248 | SEIZURES, SCOLIOSIS, AND MACROCEPHALY SYNDROME | 4 | GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | EXT2 | C0015306 | Hereditary Multiple Exostoses | 1 | CTD_human |
Hgene | EXT2 | C1832588 | Chromosome 11p11.2 Deletion Syndrome | 1 | ORPHANET |