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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EXT2-TTC17 (FusionGDB2 ID:27947)

Fusion Gene Summary for EXT2-TTC17

check button Fusion gene summary
Fusion gene informationFusion gene name: EXT2-TTC17
Fusion gene ID: 27947
HgeneTgene
Gene symbol

EXT2

TTC17

Gene ID

2132

55761

Gene nameexostosin glycosyltransferase 2tetratricopeptide repeat domain 17
SynonymsSOTV|SSMS-
Cytomap

11p11.2

11p12-p11.2

Type of geneprotein-codingprotein-coding
Descriptionexostosin-2N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferaseglucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferasemultiple exostoses protein 2multiple exostosis 2putativtetratricopeptide repeat protein 17TPR repeat protein 17
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000533608, ENST00000358681, 
ENST00000395673, ENST00000343631, 
ENST00000529186, 		ENST00000299240, 
ENST00000039989, ENST00000526774, 
Fusion gene scores* DoF score8 X 6 X 8=38410 X 10 X 4=400
# samples 911
** MAII scorelog2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EXT2 [Title/Abstract] AND TTC17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEXT2(44151688)-TTC17(43436140), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEXT2

GO:0006024

glycosaminoglycan biosynthetic process

12907669

HgeneEXT2

GO:0033692

cellular polysaccharide biosynthetic process

12907669


check buttonFusion gene breakpoints across EXT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TTC17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1842-01AEXT2chr11

44151688

+TTC17chr11

43436140

+
ChimerDB4OVTCGA-24-1842-01AEXT2chr11

44151688

+TTC17chr11

43436140

+


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Fusion Gene ORF analysis for EXT2-TTC17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000533608ENST00000299240EXT2chr11

44151688

+TTC17chr11

43436140

+
In-frameENST00000533608ENST00000039989EXT2chr11

44151688

+TTC17chr11

43436140

+
5CDS-3UTRENST00000533608ENST00000526774EXT2chr11

44151688

+TTC17chr11

43436140

+
In-frameENST00000358681ENST00000299240EXT2chr11

44151688

+TTC17chr11

43436140

+
In-frameENST00000358681ENST00000039989EXT2chr11

44151688

+TTC17chr11

43436140

+
5CDS-3UTRENST00000358681ENST00000526774EXT2chr11

44151688

+TTC17chr11

43436140

+
In-frameENST00000395673ENST00000299240EXT2chr11

44151688

+TTC17chr11

43436140

+
In-frameENST00000395673ENST00000039989EXT2chr11

44151688

+TTC17chr11

43436140

+
5CDS-3UTRENST00000395673ENST00000526774EXT2chr11

44151688

+TTC17chr11

43436140

+
In-frameENST00000343631ENST00000299240EXT2chr11

44151688

+TTC17chr11

43436140

+
In-frameENST00000343631ENST00000039989EXT2chr11

44151688

+TTC17chr11

43436140

+
5CDS-3UTRENST00000343631ENST00000526774EXT2chr11

44151688

+TTC17chr11

43436140

+
intron-3CDSENST00000529186ENST00000299240EXT2chr11

44151688

+TTC17chr11

43436140

+
intron-3CDSENST00000529186ENST00000039989EXT2chr11

44151688

+TTC17chr11

43436140

+
intron-3UTRENST00000529186ENST00000526774EXT2chr11

44151688

+TTC17chr11

43436140

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000533608EXT2chr1144151688+ENST00000299240TTC17chr1143436140+3068150742313769
ENST00000533608EXT2chr1144151688+ENST00000039989TTC17chr1143436140+3898150742868954
ENST00000358681EXT2chr1144151688+ENST00000299240TTC17chr1143436140+29001339342145703
ENST00000358681EXT2chr1144151688+ENST00000039989TTC17chr1143436140+37301339342700888
ENST00000395673EXT2chr1144151688+ENST00000299240TTC17chr1143436140+28891328382134698
ENST00000395673EXT2chr1144151688+ENST00000039989TTC17chr1143436140+37191328382689883
ENST00000343631EXT2chr1144151688+ENST00000299240TTC17chr1143436140+28631302122108698
ENST00000343631EXT2chr1144151688+ENST00000039989TTC17chr1143436140+36931302122663883

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000533608ENST00000299240EXT2chr1144151688+TTC17chr1143436140+0.0004865360.9995135
ENST00000533608ENST00000039989EXT2chr1144151688+TTC17chr1143436140+0.0004372580.9995627
ENST00000358681ENST00000299240EXT2chr1144151688+TTC17chr1143436140+0.000378240.99962175
ENST00000358681ENST00000039989EXT2chr1144151688+TTC17chr1143436140+0.0003727020.99962723
ENST00000395673ENST00000299240EXT2chr1144151688+TTC17chr1143436140+0.0001809090.9998191
ENST00000395673ENST00000039989EXT2chr1144151688+TTC17chr1143436140+0.0001341360.9998659
ENST00000343631ENST00000299240EXT2chr1144151688+TTC17chr1143436140+0.0001767610.9998233
ENST00000343631ENST00000039989EXT2chr1144151688+TTC17chr1143436140+0.0001319130.99986804

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Fusion Genomic Features for EXT2-TTC17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EXT2chr1144151688+TTC17chr1143436139+0.0014608460.9985392
EXT2chr1144151688+TTC17chr1143436139+0.0014608460.9985392

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EXT2-TTC17


check button Go to

FGviewer for the breakpoints of chr11:44151688-chr11:43436140

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEXT2chr11:44151688chr11:43436140ENST00000343631+7141_25391.0719.0Topological domainCytoplasmic
HgeneEXT2chr11:44151688chr11:43436140ENST00000358681+7151_25391.0729.0Topological domainCytoplasmic
HgeneEXT2chr11:44151688chr11:43436140ENST00000395673+7141_25424.0752.0Topological domainCytoplasmic
HgeneEXT2chr11:44151688chr11:43436140ENST00000533608+7141_25391.0719.0Topological domainCytoplasmic
HgeneEXT2chr11:44151688chr11:43436140ENST00000343631+71426_46391.0719.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneEXT2chr11:44151688chr11:43436140ENST00000358681+71526_46391.0729.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneEXT2chr11:44151688chr11:43436140ENST00000395673+71426_46424.0752.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneEXT2chr11:44151688chr11:43436140ENST00000533608+71426_46391.0719.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTTC17chr11:44151688chr11:43436140ENST0000003998914241014_1048688.01142.0RepeatNote=TPR 4
TgeneTTC17chr11:44151688chr11:43436140ENST0000003998914241051_1084688.01142.0RepeatNote=TPR 5
TgeneTTC17chr11:44151688chr11:43436140ENST0000003998914241085_1118688.01142.0RepeatNote=TPR 6
TgeneTTC17chr11:44151688chr11:43436140ENST000000399891424689_722688.01142.0RepeatNote=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEXT2chr11:44151688chr11:43436140ENST00000343631+714517_522391.0719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000343631+714538_540391.0719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000343631+714624_628391.0719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000343631+714662_673391.0719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000358681+715517_522391.0729.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000358681+715538_540391.0729.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000358681+715624_628391.0729.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000358681+715662_673391.0729.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000395673+714517_522424.0752.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000395673+714538_540424.0752.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000395673+714624_628424.0752.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000395673+714662_673424.0752.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000533608+714517_522391.0719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000533608+714538_540391.0719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000533608+714624_628391.0719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000533608+714662_673391.0719.0RegionSubstrate binding
HgeneEXT2chr11:44151688chr11:43436140ENST00000343631+71447_718391.0719.0Topological domainLumenal
HgeneEXT2chr11:44151688chr11:43436140ENST00000358681+71547_718391.0729.0Topological domainLumenal
HgeneEXT2chr11:44151688chr11:43436140ENST00000395673+71447_718424.0752.0Topological domainLumenal
HgeneEXT2chr11:44151688chr11:43436140ENST00000533608+71447_718391.0719.0Topological domainLumenal
TgeneTTC17chr11:44151688chr11:43436140ENST000000399891424340_382688.01142.0Coiled coilOntology_term=ECO:0000255
TgeneTTC17chr11:44151688chr11:43436140ENST000000399891424295_328688.01142.0RepeatNote=TPR 1
TgeneTTC17chr11:44151688chr11:43436140ENST000000399891424619_652688.01142.0RepeatNote=TPR 2


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Fusion Gene Sequence for EXT2-TTC17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000533608_ENST00000299240_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(transcript)=3068nt_BP=1507nt
CTGTCTGAGCATTTCACTGCGGAGCCTGAGCGCGCCTGCCTGGGAAAACACTGCAGCGGTGCTCGGACTCCTCCTGTCCAGCAGGAGGCG
CGGCCCGGCAGCTCCCGCATGCGCAGTGCGCTCGGTGTCAGACGGCCCGGATCCCGGTTACCGGCCCCTCGCTCGCTGCTCGCCAGCCCA
GACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGAGCCGGTGACCAA
GCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATAT
CCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGC
CACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGT
TAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAA
CCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGA
GTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGT
GCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTT
CAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTAC
GTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCC
ACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTC
AGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCC
ACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTG
TGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAA
GATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGGG
AAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTGA
AAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAATTGTCATGAGAA
AACCCTGGACAACAGCCATGACAAACAGAAATATTTTGACAACTCACAGTCACTGGATGCTGCTGAAGAAGAGCCCTCTGAGAGAGGAAC
AGAGGAGGACCCTGTATTCTCTGTTGAGAATTCAGGGAGGGACTCAGATGCCCTTAGACTTGAAAGTACGGTGGTTGAGGAGAGCAATGG
TTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATGGCCTTTGGA
AGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGATGGAGTGGC
CAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAAGAAACCCAA
AGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGAGATCACTGG
CCCCAAGGTGGCATCTCCTGGGCCACAAGGGCTACTAGACTGGAAGACCAGGAAAGTGCCATAGACATAATGTAACTGGATTTCAGCAAG
GCATTTAACAGAGCCTCTTATGATATCCTTGTGAACCAGATGGAGAGATGTGGGCTTGAAGCCTTCCCATTGCCTACAGGATAAAATTCA
AACTTCCTAGTGTGGTGTACAAGACCCTTTACAGCCCGCCTCTGTGTACCCTTCAACACCATTCTCTGAACCAACCATGCTCATGTTTTT
ACCTCAGTGCCTTTGCACATGCTATTCCCTCTGCCTGGAATGCCCTGTGCCCCCTCTGCCCTCTGCCGTGCTAAAATATCACTCATCCTT
AAACTTCAAAATCAAGTGCCATCTCTTCCTTGTTACCTTCAGGCAGAATTAGTTACTCTTTCCTCTGTGCAATTGTTCTATATCTTCGCT
CTAGCTCTTTTCCTGTTGTATTGTAATGATTTGTTTATGTTTACCTTCCTTACTAGACTGTGAGCTCAAGAGCAGGCCGTCTTAATTATT
CCTTTCTGTACCCCTAGTGTCTTTTATGGTTCTCAGCCCCTTATAACAGGTGCTCAATAAATATTTTTCAAATGAAATTATTAAATGTAA
AAGAAAATTAAGATTTTTTGTGAAAATTATGGCTTATTTAAGTTATTAATTTAAACAGAGTTAATTTGAAACTCTTCCAAAACTGTTCCT
TTCTGTTTTGTTAAAATCTCAATCTAAACCCCTGCCTGTACCTCAAACAGTTTTCTACTGTTCGTAAATTCCTATAATATAAAAAGCGCT

>In-frame_ENST00000533608_ENST00000299240_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(amino acids)=769AA_start in transcript=4_stop in transcript=2313
MSISLRSLSAPAWENTAAVLGLLLSSRRRGPAAPACAVRSVSDGPDPGYRPLARCSPAQTRPWQWRLAIRTDPTWAEVARAPRHEPVTKL
GAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVR
LPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVL
NQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPR
QYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCV
PVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECEN
SLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSHDKQKYFDNSQSLDAAEEEPSERGTEEDPVFSVENSGRDSDALRLESTVVEESNGS
DEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKG

--------------------------------------------------------------
>In-frame_ENST00000533608_ENST00000039989_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(transcript)=3898nt_BP=1507nt
CTGTCTGAGCATTTCACTGCGGAGCCTGAGCGCGCCTGCCTGGGAAAACACTGCAGCGGTGCTCGGACTCCTCCTGTCCAGCAGGAGGCG
CGGCCCGGCAGCTCCCGCATGCGCAGTGCGCTCGGTGTCAGACGGCCCGGATCCCGGTTACCGGCCCCTCGCTCGCTGCTCGCCAGCCCA
GACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGAGCCGGTGACCAA
GCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATAT
CCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGC
CACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGT
TAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAA
CCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGA
GTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGT
GCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTT
CAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTAC
GTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCC
ACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTC
AGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCC
ACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTG
TGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAA
GATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGGG
AAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTGA
AAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTACGGTGGTTGAGGA
GAGCAATGGTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATG
GCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGA
TGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAA
GAAACCCAAAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGA
GATCACTGGCCCCAAGGTGGCATCTCCTGGGCCACAAGGAAAAAAACGTGACTACCAGCGTCTGGGATGGCCCAGCCCGGACGAATGCCT
CAAACTCCGCTGGGTAGAGCTGACTGCCATCGTGAGTACCTGGCTTGCAGTTTCTTCAAAAAACATTGACATCACAGAACACATAGATTT
TGCCACCCCTATACAGCAGCCAGCAATGGAGCCTCTTTGCAATGGCAATCTCCCCACGAGTATGCATACCCTGGACCACTTGCATGGGGT
TTCCAACCGAGCCAGCCTGCACTACACAGGGGAGAGTCAGTTAACAGAGGTATTACAAAATCTCGGCAAAGACCAATATCCACAACAGTC
GCTTGAACAGATTGGCACCCGAATTGCCAAAGTTTTGGAAAAGAACCAGACGTCCTGGGTCCTCTCCAGCATGGCAGCCCTCTACTGGAG
GGTGAAAGGCCAAGGAAAGAAGGCAATCGACTGCCTCCGCCAGGCTCTGCACTATGCGCCACACCAGATGAAGGATGTGCCCCTGATTAG
CCTGGCCAACATCTTGCACAATGCCAAGCTCTGGAATGACGCCGTCATAGTAGCCACCATGGCAGTAGAGATCGCACCACACTTTGCTGT
GAACCACTTCACTCTGGGCAATGTCTACGTGGCAATGGAAGAATTTGAAAAAGCACTGGTGTGGTATGAATCCACATTGAAGCTTCAGCC
CGAGTTTGTCCCAGCCAAGAACCGAATCCAGACCATCCAGTGTCACTTAATGCTGAAGAAGGGACGGCGCTCTCCTTAGTGCACTTCTTC
CTTCTCTCTTTCTCTTTACTCATGCTCTAAAAAAAAAGAATAAGAAAAGAAACCAATCATTGTCAGTATCTACTATTAATGATGTGTGTG
AAAATAACTAAGACTTATAACAGGACTTTTACATATGTGGGAATTGGTTTGTTTTTGTTTTTACGTTTCTCCTTTCCCCCAACCAACCTC
AGAAGAGGCACCTTCAGAAACACACATTTCTTAAAAGGAAAGTGCAGCTTCAAGATATTGTGTAAATACTGAGCCAAGACATTTCTGGAG
CTGTGCTCTGTCTCCAAAAACCTCAATGCCTTTAGGGCTTTTCTCAGTGGTCCAGCTAGCCTTCTCTTTGGAGGAGGATGAAGCCGCATT
GCACATTCTCTGCTTCCTGTCGTAGCCTCTGTTGTCAATGGAAATGCGGAAGCCCATCTGGTGCCCGTCAGTGAGAAGCAACGTTCTGCG
CTCTCTCCGTTAGACCTCCATGCTGTCCCCAGTCTTGTCCATTCCATGCTGCTGTGTTACAAACTCTCAGAGGTAGTTTGCAGGGGAGGA
AGGGGAATATGATTTTAAAAACAAAATATTTACAACAACAAAAATTCTTAGGATCACCTGACCTTTGTAATGTTATTTATGTTGGGGAGG
GAGGGGGGCTGAGAAGGGGAAATCAGCAGTGTGCAACATCTTTATAATTTGTACTTTAATTACAAATCACAAGGAAACCAATAAGTTGAA
ATCCTATATAACAGGTTTATATATATAGAATATGTATATTTGAAGCCCTCTACAGACTGAGTCTATGTTTTACTAATTCTTTGTTCACTG
TGTTACCCATCTTGGAATAAGTTGTGAATGTCAGCTCCCTCTCTCTGAGGCCTCCAGACTTAGCTCCTCAGGAGGGTAATGAGCCAAGGT
TGAGTGTTTCCATACAATGCTTTTACCTTTGATCCCAGGAGAATCAGAAACTCCAACATTTTGGAATCTTCAAGGGCACATACTGAGAAA

>In-frame_ENST00000533608_ENST00000039989_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(amino acids)=954AA_start in transcript=4_stop in transcript=2868
MSISLRSLSAPAWENTAAVLGLLLSSRRRGPAAPACAVRSVSDGPDPGYRPLARCSPAQTRPWQWRLAIRTDPTWAEVARAPRHEPVTKL
GAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVR
LPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVL
NQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPR
QYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCV
PVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECEN
SLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDG
VARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQGKKRDYQRLGWPSPDECLK
LRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSL
EQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVN

--------------------------------------------------------------
>In-frame_ENST00000358681_ENST00000299240_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(transcript)=2900nt_BP=1339nt
CTCGCCAGCCCAGACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGA
GCCGGTGACCAAGCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGT
CAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCT
GGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGA
TGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCG
CTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACAC
CATCTCCCGGGAGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCC
CTCCATCGATGTGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAA
TCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGG
CGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAA
AGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAA
ACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGT
CTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTT
ACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGT
ACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTT
TTTGAGCCTGGGAAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATG
TCCAGAGTGTGAAAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAA
TTGTCATGAGAAAACCCTGGACAACAGCCATGACAAACAGAAATATTTTGACAACTCACAGTCACTGGATGCTGCTGAAGAAGAGCCCTC
TGAGAGAGGAACAGAGGAGGACCCTGTATTCTCTGTTGAGAATTCAGGGAGGGACTCAGATGCCCTTAGACTTGAAAGTACGGTGGTTGA
GGAGAGCAATGGTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGC
ATGGCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCA
GGATGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGT
AAAGAAACCCAAAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCT
AGAGATCACTGGCCCCAAGGTGGCATCTCCTGGGCCACAAGGGCTACTAGACTGGAAGACCAGGAAAGTGCCATAGACATAATGTAACTG
GATTTCAGCAAGGCATTTAACAGAGCCTCTTATGATATCCTTGTGAACCAGATGGAGAGATGTGGGCTTGAAGCCTTCCCATTGCCTACA
GGATAAAATTCAAACTTCCTAGTGTGGTGTACAAGACCCTTTACAGCCCGCCTCTGTGTACCCTTCAACACCATTCTCTGAACCAACCAT
GCTCATGTTTTTACCTCAGTGCCTTTGCACATGCTATTCCCTCTGCCTGGAATGCCCTGTGCCCCCTCTGCCCTCTGCCGTGCTAAAATA
TCACTCATCCTTAAACTTCAAAATCAAGTGCCATCTCTTCCTTGTTACCTTCAGGCAGAATTAGTTACTCTTTCCTCTGTGCAATTGTTC
TATATCTTCGCTCTAGCTCTTTTCCTGTTGTATTGTAATGATTTGTTTATGTTTACCTTCCTTACTAGACTGTGAGCTCAAGAGCAGGCC
GTCTTAATTATTCCTTTCTGTACCCCTAGTGTCTTTTATGGTTCTCAGCCCCTTATAACAGGTGCTCAATAAATATTTTTCAAATGAAAT
TATTAAATGTAAAAGAAAATTAAGATTTTTTGTGAAAATTATGGCTTATTTAAGTTATTAATTTAAACAGAGTTAATTTGAAACTCTTCC
AAAACTGTTCCTTTCTGTTTTGTTAAAATCTCAATCTAAACCCCTGCCTGTACCTCAAACAGTTTTCTACTGTTCGTAAATTCCTATAAT

>In-frame_ENST00000358681_ENST00000299240_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(amino acids)=703AA_start in transcript=34_stop in transcript=2145
MAIRTDPTWAEVARAPRHEPVTKLGAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFW
PHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMA
ISDSDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGY
DVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEAT
FCVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALK
NISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSHDKQKYFDNSQSLDAAEEEPSERGTEEDPVFS
VENSGRDSDALRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGD

--------------------------------------------------------------
>In-frame_ENST00000358681_ENST00000039989_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(transcript)=3730nt_BP=1339nt
CTCGCCAGCCCAGACTCGGCCCTGGCAGTGGCGGCTGGCGATTCGGACCGATCCGACCTGGGCGGAGGTGGCCCGCGCCCCGCGGCATGA
GCCGGTGACCAAGCTCGGGGCCGAGCGGGAGGCAGCCGTGGCCGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGT
CAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCT
GGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGA
TGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCG
CTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACAC
CATCTCCCGGGAGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCC
CTCCATCGATGTGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAA
TCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGG
CGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAA
AGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAA
ACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGT
CTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTT
ACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGT
ACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTT
TTTGAGCCTGGGAAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATG
TCCAGAGTGTGAAAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAC
GGTGGTTGAGGAGAGCAATGGTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATT
TCAACAGGCATGGCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAA
AGGTCCCCAGGATGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGT
CAAACGTGTAAAGAAACCCAAAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCA
AGCAAACCTAGAGATCACTGGCCCCAAGGTGGCATCTCCTGGGCCACAAGGAAAAAAACGTGACTACCAGCGTCTGGGATGGCCCAGCCC
GGACGAATGCCTCAAACTCCGCTGGGTAGAGCTGACTGCCATCGTGAGTACCTGGCTTGCAGTTTCTTCAAAAAACATTGACATCACAGA
ACACATAGATTTTGCCACCCCTATACAGCAGCCAGCAATGGAGCCTCTTTGCAATGGCAATCTCCCCACGAGTATGCATACCCTGGACCA
CTTGCATGGGGTTTCCAACCGAGCCAGCCTGCACTACACAGGGGAGAGTCAGTTAACAGAGGTATTACAAAATCTCGGCAAAGACCAATA
TCCACAACAGTCGCTTGAACAGATTGGCACCCGAATTGCCAAAGTTTTGGAAAAGAACCAGACGTCCTGGGTCCTCTCCAGCATGGCAGC
CCTCTACTGGAGGGTGAAAGGCCAAGGAAAGAAGGCAATCGACTGCCTCCGCCAGGCTCTGCACTATGCGCCACACCAGATGAAGGATGT
GCCCCTGATTAGCCTGGCCAACATCTTGCACAATGCCAAGCTCTGGAATGACGCCGTCATAGTAGCCACCATGGCAGTAGAGATCGCACC
ACACTTTGCTGTGAACCACTTCACTCTGGGCAATGTCTACGTGGCAATGGAAGAATTTGAAAAAGCACTGGTGTGGTATGAATCCACATT
GAAGCTTCAGCCCGAGTTTGTCCCAGCCAAGAACCGAATCCAGACCATCCAGTGTCACTTAATGCTGAAGAAGGGACGGCGCTCTCCTTA
GTGCACTTCTTCCTTCTCTCTTTCTCTTTACTCATGCTCTAAAAAAAAAGAATAAGAAAAGAAACCAATCATTGTCAGTATCTACTATTA
ATGATGTGTGTGAAAATAACTAAGACTTATAACAGGACTTTTACATATGTGGGAATTGGTTTGTTTTTGTTTTTACGTTTCTCCTTTCCC
CCAACCAACCTCAGAAGAGGCACCTTCAGAAACACACATTTCTTAAAAGGAAAGTGCAGCTTCAAGATATTGTGTAAATACTGAGCCAAG
ACATTTCTGGAGCTGTGCTCTGTCTCCAAAAACCTCAATGCCTTTAGGGCTTTTCTCAGTGGTCCAGCTAGCCTTCTCTTTGGAGGAGGA
TGAAGCCGCATTGCACATTCTCTGCTTCCTGTCGTAGCCTCTGTTGTCAATGGAAATGCGGAAGCCCATCTGGTGCCCGTCAGTGAGAAG
CAACGTTCTGCGCTCTCTCCGTTAGACCTCCATGCTGTCCCCAGTCTTGTCCATTCCATGCTGCTGTGTTACAAACTCTCAGAGGTAGTT
TGCAGGGGAGGAAGGGGAATATGATTTTAAAAACAAAATATTTACAACAACAAAAATTCTTAGGATCACCTGACCTTTGTAATGTTATTT
ATGTTGGGGAGGGAGGGGGGCTGAGAAGGGGAAATCAGCAGTGTGCAACATCTTTATAATTTGTACTTTAATTACAAATCACAAGGAAAC
CAATAAGTTGAAATCCTATATAACAGGTTTATATATATAGAATATGTATATTTGAAGCCCTCTACAGACTGAGTCTATGTTTTACTAATT
CTTTGTTCACTGTGTTACCCATCTTGGAATAAGTTGTGAATGTCAGCTCCCTCTCTCTGAGGCCTCCAGACTTAGCTCCTCAGGAGGGTA
ATGAGCCAAGGTTGAGTGTTTCCATACAATGCTTTTACCTTTGATCCCAGGAGAATCAGAAACTCCAACATTTTGGAATCTTCAAGGGCA

>In-frame_ENST00000358681_ENST00000039989_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(amino acids)=888AA_start in transcript=34_stop in transcript=2700
MAIRTDPTWAEVARAPRHEPVTKLGAEREAAVAEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFW
PHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMA
ISDSDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGY
DVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEAT
FCVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALK
NISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGG
ALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVA
SPGPQGKKRDYQRLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLH
YTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHN

--------------------------------------------------------------
>In-frame_ENST00000395673_ENST00000299240_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(transcript)=2889nt_BP=1328nt
TCCCTTCCTGCTGCCACCTTCCCGCCAGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGC
GGCATCCCTTGCGGTGCCAGAAGCCGTGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATA
TCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTG
CCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTG
TTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCA
ACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGG
AGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATG
TGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGT
TCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTA
CGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTC
CACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGT
CAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACC
CACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCT
GTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAA
AGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGG
GAAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTG
AAAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAATTGTCATGAGA
AAACCCTGGACAACAGCCATGACAAACAGAAATATTTTGACAACTCACAGTCACTGGATGCTGCTGAAGAAGAGCCCTCTGAGAGAGGAA
CAGAGGAGGACCCTGTATTCTCTGTTGAGAATTCAGGGAGGGACTCAGATGCCCTTAGACTTGAAAGTACGGTGGTTGAGGAGAGCAATG
GTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATGGCCTTTGG
AAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGATGGAGTGG
CCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAAGAAACCCA
AAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGAGATCACTG
GCCCCAAGGTGGCATCTCCTGGGCCACAAGGGCTACTAGACTGGAAGACCAGGAAAGTGCCATAGACATAATGTAACTGGATTTCAGCAA
GGCATTTAACAGAGCCTCTTATGATATCCTTGTGAACCAGATGGAGAGATGTGGGCTTGAAGCCTTCCCATTGCCTACAGGATAAAATTC
AAACTTCCTAGTGTGGTGTACAAGACCCTTTACAGCCCGCCTCTGTGTACCCTTCAACACCATTCTCTGAACCAACCATGCTCATGTTTT
TACCTCAGTGCCTTTGCACATGCTATTCCCTCTGCCTGGAATGCCCTGTGCCCCCTCTGCCCTCTGCCGTGCTAAAATATCACTCATCCT
TAAACTTCAAAATCAAGTGCCATCTCTTCCTTGTTACCTTCAGGCAGAATTAGTTACTCTTTCCTCTGTGCAATTGTTCTATATCTTCGC
TCTAGCTCTTTTCCTGTTGTATTGTAATGATTTGTTTATGTTTACCTTCCTTACTAGACTGTGAGCTCAAGAGCAGGCCGTCTTAATTAT
TCCTTTCTGTACCCCTAGTGTCTTTTATGGTTCTCAGCCCCTTATAACAGGTGCTCAATAAATATTTTTCAAATGAAATTATTAAATGTA
AAAGAAAATTAAGATTTTTTGTGAAAATTATGGCTTATTTAAGTTATTAATTTAAACAGAGTTAATTTGAAACTCTTCCAAAACTGTTCC
TTTCTGTTTTGTTAAAATCTCAATCTAAACCCCTGCCTGTACCTCAAACAGTTTTCTACTGTTCGTAAATTCCTATAATATAAAAAGCGC

>In-frame_ENST00000395673_ENST00000299240_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(amino acids)=698AA_start in transcript=38_stop in transcript=2134
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGA
LEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSHDKQKYFDNSQSLDAAEEEPSERGTEEDPVFSVENSG
RDSDALRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSED

--------------------------------------------------------------
>In-frame_ENST00000395673_ENST00000039989_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(transcript)=3719nt_BP=1328nt
TCCCTTCCTGCTGCCACCTTCCCGCCAGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGC
GGCATCCCTTGCGGTGCCAGAAGCCGTGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATA
TCCGGGGTCCTGCCCTCATCCCAAGAATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTG
CCACTGGCATGTTTCAGTTTTGGCCCCATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTG
TTAGGCTGCCAGCCGACAGTCCCATCCCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCA
ACCCAAAGAACAAAATCAAGGTGTATATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGG
AGTATAATGAACTGCTCATGGCCATCTCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATG
TGCTTAACCAGAACACACTGCGCATCAAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGT
TCAACATGTTGCCTGGAGGTCCCCCAGATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTA
CGTGGACTTACCGGCAAGGCTACGATGTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTC
CACGGCAATACTTCCTCCTGTCATCTCAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGT
CAGTGTTAGTACTCGATAAATGCACCAACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACC
CACAGGTGCTACAGGAGGCTACTTTCTGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCT
GTGTCCCGGTTGTCATTGCAGACTCCTATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAA
AGATGTCAGATGTGTACAGTATTTTGCAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGG
GAAATGCTTACCTTGCTCTGAAGAATATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTG
AAAACAGCCTGAAGTTGATCCGCTGTATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTACGGTGGTTGAGG
AGAGCAATGGTTCTGATGAGATGGAGAATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCAT
GGCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGG
ATGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAA
AGAAACCCAAAGGAGATCATAAGAAAACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAG
AGATCACTGGCCCCAAGGTGGCATCTCCTGGGCCACAAGGAAAAAAACGTGACTACCAGCGTCTGGGATGGCCCAGCCCGGACGAATGCC
TCAAACTCCGCTGGGTAGAGCTGACTGCCATCGTGAGTACCTGGCTTGCAGTTTCTTCAAAAAACATTGACATCACAGAACACATAGATT
TTGCCACCCCTATACAGCAGCCAGCAATGGAGCCTCTTTGCAATGGCAATCTCCCCACGAGTATGCATACCCTGGACCACTTGCATGGGG
TTTCCAACCGAGCCAGCCTGCACTACACAGGGGAGAGTCAGTTAACAGAGGTATTACAAAATCTCGGCAAAGACCAATATCCACAACAGT
CGCTTGAACAGATTGGCACCCGAATTGCCAAAGTTTTGGAAAAGAACCAGACGTCCTGGGTCCTCTCCAGCATGGCAGCCCTCTACTGGA
GGGTGAAAGGCCAAGGAAAGAAGGCAATCGACTGCCTCCGCCAGGCTCTGCACTATGCGCCACACCAGATGAAGGATGTGCCCCTGATTA
GCCTGGCCAACATCTTGCACAATGCCAAGCTCTGGAATGACGCCGTCATAGTAGCCACCATGGCAGTAGAGATCGCACCACACTTTGCTG
TGAACCACTTCACTCTGGGCAATGTCTACGTGGCAATGGAAGAATTTGAAAAAGCACTGGTGTGGTATGAATCCACATTGAAGCTTCAGC
CCGAGTTTGTCCCAGCCAAGAACCGAATCCAGACCATCCAGTGTCACTTAATGCTGAAGAAGGGACGGCGCTCTCCTTAGTGCACTTCTT
CCTTCTCTCTTTCTCTTTACTCATGCTCTAAAAAAAAAGAATAAGAAAAGAAACCAATCATTGTCAGTATCTACTATTAATGATGTGTGT
GAAAATAACTAAGACTTATAACAGGACTTTTACATATGTGGGAATTGGTTTGTTTTTGTTTTTACGTTTCTCCTTTCCCCCAACCAACCT
CAGAAGAGGCACCTTCAGAAACACACATTTCTTAAAAGGAAAGTGCAGCTTCAAGATATTGTGTAAATACTGAGCCAAGACATTTCTGGA
GCTGTGCTCTGTCTCCAAAAACCTCAATGCCTTTAGGGCTTTTCTCAGTGGTCCAGCTAGCCTTCTCTTTGGAGGAGGATGAAGCCGCAT
TGCACATTCTCTGCTTCCTGTCGTAGCCTCTGTTGTCAATGGAAATGCGGAAGCCCATCTGGTGCCCGTCAGTGAGAAGCAACGTTCTGC
GCTCTCTCCGTTAGACCTCCATGCTGTCCCCAGTCTTGTCCATTCCATGCTGCTGTGTTACAAACTCTCAGAGGTAGTTTGCAGGGGAGG
AAGGGGAATATGATTTTAAAAACAAAATATTTACAACAACAAAAATTCTTAGGATCACCTGACCTTTGTAATGTTATTTATGTTGGGGAG
GGAGGGGGGCTGAGAAGGGGAAATCAGCAGTGTGCAACATCTTTATAATTTGTACTTTAATTACAAATCACAAGGAAACCAATAAGTTGA
AATCCTATATAACAGGTTTATATATATAGAATATGTATATTTGAAGCCCTCTACAGACTGAGTCTATGTTTTACTAATTCTTTGTTCACT
GTGTTACCCATCTTGGAATAAGTTGTGAATGTCAGCTCCCTCTCTCTGAGGCCTCCAGACTTAGCTCCTCAGGAGGGTAATGAGCCAAGG
TTGAGTGTTTCCATACAATGCTTTTACCTTTGATCCCAGGAGAATCAGAAACTCCAACATTTTGGAATCTTCAAGGGCACATACTGAGAA

>In-frame_ENST00000395673_ENST00000039989_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(amino acids)=883AA_start in transcript=38_stop in transcript=2689
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGA
LEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMK
GRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQ
GKKRDYQRLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGES
QLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWN

--------------------------------------------------------------
>In-frame_ENST00000343631_ENST00000299240_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(transcript)=2863nt_BP=1302nt
AGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGCGGCATCCCTTGCGGTGCCAGAAGCCG
TGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGA
ATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCC
CATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATC
CCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTAT
ATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGAGTATAATGAACTGCTCATGGCCATC
TCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGTGCTTAACCAGAACACACTGCGCATC
AAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCA
GATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGAT
GTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCT
CAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACC
AACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTC
TGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCC
TATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTG
CAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGGGAAATGCTTACCTTGCTCTGAAGAAT
ATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTGAAAACAGCCTGAAGTTGATCCGCTGT
ATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTAATTGTCATGAGAAAACCCTGGACAACAGCCATGACAAA
CAGAAATATTTTGACAACTCACAGTCACTGGATGCTGCTGAAGAAGAGCCCTCTGAGAGAGGAACAGAGGAGGACCCTGTATTCTCTGTT
GAGAATTCAGGGAGGGACTCAGATGCCCTTAGACTTGAAAGTACGGTGGTTGAGGAGAGCAATGGTTCTGATGAGATGGAGAATTCAGAT
GAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATGGCCTTTGGAAGGCTTTGGGGGTGCACTAGAGATG
AAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGATGGAGTGGCCAGAAGCTCTTGCTATGGAGACTGC
AGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAAGAAACCCAAAGGAGATCATAAGAAAACTCCTGGG
AAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGAGATCACTGGCCCCAAGGTGGCATCTCCTGGGCCA
CAAGGGCTACTAGACTGGAAGACCAGGAAAGTGCCATAGACATAATGTAACTGGATTTCAGCAAGGCATTTAACAGAGCCTCTTATGATA
TCCTTGTGAACCAGATGGAGAGATGTGGGCTTGAAGCCTTCCCATTGCCTACAGGATAAAATTCAAACTTCCTAGTGTGGTGTACAAGAC
CCTTTACAGCCCGCCTCTGTGTACCCTTCAACACCATTCTCTGAACCAACCATGCTCATGTTTTTACCTCAGTGCCTTTGCACATGCTAT
TCCCTCTGCCTGGAATGCCCTGTGCCCCCTCTGCCCTCTGCCGTGCTAAAATATCACTCATCCTTAAACTTCAAAATCAAGTGCCATCTC
TTCCTTGTTACCTTCAGGCAGAATTAGTTACTCTTTCCTCTGTGCAATTGTTCTATATCTTCGCTCTAGCTCTTTTCCTGTTGTATTGTA
ATGATTTGTTTATGTTTACCTTCCTTACTAGACTGTGAGCTCAAGAGCAGGCCGTCTTAATTATTCCTTTCTGTACCCCTAGTGTCTTTT
ATGGTTCTCAGCCCCTTATAACAGGTGCTCAATAAATATTTTTCAAATGAAATTATTAAATGTAAAAGAAAATTAAGATTTTTTGTGAAA
ATTATGGCTTATTTAAGTTATTAATTTAAACAGAGTTAATTTGAAACTCTTCCAAAACTGTTCCTTTCTGTTTTGTTAAAATCTCAATCT

>In-frame_ENST00000343631_ENST00000299240_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(amino acids)=698AA_start in transcript=12_stop in transcript=2108
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGA
LEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHEKTLDNSHDKQKYFDNSQSLDAAEEEPSERGTEEDPVFSVENSG
RDSDALRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSED

--------------------------------------------------------------
>In-frame_ENST00000343631_ENST00000039989_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(transcript)=3693nt_BP=1302nt
AGCCACAGGGATCTGATTCCTCCCAGGGGGATGTCCTGCGCCTCAGGGTCCGGTGGTGGCCTGCGGCATCCCTTGCGGTGCCAGAAGCCG
TGGGACGAGGAGTGTGAGGAAGAGGCTGTCTGTGTCATTATGTGTGCGTCGGTCAAGTATAATATCCGGGGTCCTGCCCTCATCCCAAGA
ATGAAGACCAAGCACCGAATCTACTATATCACCCTCTTCTCCATTGTCCTCCTGGGCCTCATTGCCACTGGCATGTTTCAGTTTTGGCCC
CATTCTATCGAGTCCTCAAATGACTGGAATGTAGAGAAGCGCAGCATCCGTGATGTGCCGGTTGTTAGGCTGCCAGCCGACAGTCCCATC
CCAGAGCGGGGGGATCTCAGTTGCAGAATGCACACGTGTTTTGATGTCTATCGCTGTGGCTTCAACCCAAAGAACAAAATCAAGGTGTAT
ATCTATGCTCTGAAAAAGTACGTGGATGACTTTGGCGTCTCTGTCAGCAACACCATCTCCCGGGAGTATAATGAACTGCTCATGGCCATC
TCAGACAGTGACTACTACACTGATGACATCAACCGGGCCTGTCTGTTTGTTCCCTCCATCGATGTGCTTAACCAGAACACACTGCGCATC
AAGGAGACAGCACAAGCGATGGCCCAGCTCTCTAGGTGGGATCGAGGTACGAATCACCTGTTGTTCAACATGTTGCCTGGAGGTCCCCCA
GATTATAACACAGCCCTGGATGTCCCCAGAGACAGGGCCCTGTTGGCTGGTGGCGGCTTTTCTACGTGGACTTACCGGCAAGGCTACGAT
GTCAGCATTCCTGTCTATAGTCCACTGTCAGCTGAGGTGGATCTTCCAGAGAAAGGACCAGGTCCACGGCAATACTTCCTCCTGTCATCT
CAGGTGGGTCTCCATCCTGAGTACAGAGAGGACCTAGAAGCCCTCCAGGTCAAACATGGAGAGTCAGTGTTAGTACTCGATAAATGCACC
AACCTCTCAGAGGGTGTCCTTTCTGTCCGTAAGCGCTGCCACAAGCACCAGGTCTTCGATTACCCACAGGTGCTACAGGAGGCTACTTTC
TGTGTGGTTCTTCGTGGAGCTCGGCTGGGCCAGGCAGTATTGAGCGATGTGTTACAAGCTGGCTGTGTCCCGGTTGTCATTGCAGACTCC
TATATTTTGCCTTTCTCTGAAGTTCTTGACTGGAAGAGAGCATCTGTGGTTGTACCAGAAGAAAAGATGTCAGATGTGTACAGTATTTTG
CAGAGCATCCCCCAAAGACAGATTGAAGAAATGCAGAGACAGCCTCTGACCTTTTTGAGCCTGGGAAATGCTTACCTTGCTCTGAAGAAT
ATCAGTGGGGCACTTGAGGCCTTTAGACAGGCCTTGAAATTAACCACCAAATGTCCAGAGTGTGAAAACAGCCTGAAGTTGATCCGCTGT
ATGCAGTTTTATCCTTTTCTGTACAACATCACTTCTTCTGTTTGCAGTGGTACGGTGGTTGAGGAGAGCAATGGTTCTGATGAGATGGAG
AATTCAGATGAAACCAAAATGTCAGAAGAAATACTGGCTTTGGTGGATGAATTTCAACAGGCATGGCCTTTGGAAGGCTTTGGGGGTGCA
CTAGAGATGAAAGGGCGGCGTCTAGACTTACAAGGAATACGGGTGCTGAAGAAAGGTCCCCAGGATGGAGTGGCCAGAAGCTCTTGCTAT
GGAGACTGCAGAAGTGAAGATGATGAAGCAACAGAATGGATTACATTCCAGGTCAAACGTGTAAAGAAACCCAAAGGAGATCATAAGAAA
ACTCCTGGGAAAAAAGTAGAAACAGGTCAGATAGAAAATGGACATCGTTACCAAGCAAACCTAGAGATCACTGGCCCCAAGGTGGCATCT
CCTGGGCCACAAGGAAAAAAACGTGACTACCAGCGTCTGGGATGGCCCAGCCCGGACGAATGCCTCAAACTCCGCTGGGTAGAGCTGACT
GCCATCGTGAGTACCTGGCTTGCAGTTTCTTCAAAAAACATTGACATCACAGAACACATAGATTTTGCCACCCCTATACAGCAGCCAGCA
ATGGAGCCTCTTTGCAATGGCAATCTCCCCACGAGTATGCATACCCTGGACCACTTGCATGGGGTTTCCAACCGAGCCAGCCTGCACTAC
ACAGGGGAGAGTCAGTTAACAGAGGTATTACAAAATCTCGGCAAAGACCAATATCCACAACAGTCGCTTGAACAGATTGGCACCCGAATT
GCCAAAGTTTTGGAAAAGAACCAGACGTCCTGGGTCCTCTCCAGCATGGCAGCCCTCTACTGGAGGGTGAAAGGCCAAGGAAAGAAGGCA
ATCGACTGCCTCCGCCAGGCTCTGCACTATGCGCCACACCAGATGAAGGATGTGCCCCTGATTAGCCTGGCCAACATCTTGCACAATGCC
AAGCTCTGGAATGACGCCGTCATAGTAGCCACCATGGCAGTAGAGATCGCACCACACTTTGCTGTGAACCACTTCACTCTGGGCAATGTC
TACGTGGCAATGGAAGAATTTGAAAAAGCACTGGTGTGGTATGAATCCACATTGAAGCTTCAGCCCGAGTTTGTCCCAGCCAAGAACCGA
ATCCAGACCATCCAGTGTCACTTAATGCTGAAGAAGGGACGGCGCTCTCCTTAGTGCACTTCTTCCTTCTCTCTTTCTCTTTACTCATGC
TCTAAAAAAAAAGAATAAGAAAAGAAACCAATCATTGTCAGTATCTACTATTAATGATGTGTGTGAAAATAACTAAGACTTATAACAGGA
CTTTTACATATGTGGGAATTGGTTTGTTTTTGTTTTTACGTTTCTCCTTTCCCCCAACCAACCTCAGAAGAGGCACCTTCAGAAACACAC
ATTTCTTAAAAGGAAAGTGCAGCTTCAAGATATTGTGTAAATACTGAGCCAAGACATTTCTGGAGCTGTGCTCTGTCTCCAAAAACCTCA
ATGCCTTTAGGGCTTTTCTCAGTGGTCCAGCTAGCCTTCTCTTTGGAGGAGGATGAAGCCGCATTGCACATTCTCTGCTTCCTGTCGTAG
CCTCTGTTGTCAATGGAAATGCGGAAGCCCATCTGGTGCCCGTCAGTGAGAAGCAACGTTCTGCGCTCTCTCCGTTAGACCTCCATGCTG
TCCCCAGTCTTGTCCATTCCATGCTGCTGTGTTACAAACTCTCAGAGGTAGTTTGCAGGGGAGGAAGGGGAATATGATTTTAAAAACAAA
ATATTTACAACAACAAAAATTCTTAGGATCACCTGACCTTTGTAATGTTATTTATGTTGGGGAGGGAGGGGGGCTGAGAAGGGGAAATCA
GCAGTGTGCAACATCTTTATAATTTGTACTTTAATTACAAATCACAAGGAAACCAATAAGTTGAAATCCTATATAACAGGTTTATATATA
TAGAATATGTATATTTGAAGCCCTCTACAGACTGAGTCTATGTTTTACTAATTCTTTGTTCACTGTGTTACCCATCTTGGAATAAGTTGT
GAATGTCAGCTCCCTCTCTCTGAGGCCTCCAGACTTAGCTCCTCAGGAGGGTAATGAGCCAAGGTTGAGTGTTTCCATACAATGCTTTTA
CCTTTGATCCCAGGAGAATCAGAAACTCCAACATTTTGGAATCTTCAAGGGCACATACTGAGAAAAAAAATAAAATTGTTTATGAGCAAA

>In-frame_ENST00000343631_ENST00000039989_TCGA-24-1842-01A_EXT2_chr11_44151688_+_TTC17_chr11_43436140_length(amino acids)=883AA_start in transcript=12_stop in transcript=2663
MIPPRGMSCASGSGGGLRHPLRCQKPWDEECEEEAVCVIMCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIE
SSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSD
YYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIP
VYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVL
RGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQPLTFLSLGNAYLALKNISGA
LEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMK
GRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQ
GKKRDYQRLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGES
QLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EXT2-TTC17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EXT2-TTC17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EXT2-TTC17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEXT2C1851413EXOSTOSES, MULTIPLE, TYPE II18CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneEXT2C4225248SEIZURES, SCOLIOSIS, AND MACROCEPHALY SYNDROME4GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneEXT2C0015306Hereditary Multiple Exostoses1CTD_human
HgeneEXT2C1832588Chromosome 11p11.2 Deletion Syndrome1ORPHANET