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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FAF2-KIAA1191 (FusionGDB2 ID:28176) |
Fusion Gene Summary for FAF2-KIAA1191 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAF2-KIAA1191 | Fusion gene ID: 28176 | Hgene | Tgene | Gene symbol | FAF2 | KIAA1191 | Gene ID | 23197 | 57179 |
| Gene name | Fas associated factor family member 2 | KIAA1191 | |
| Synonyms | ETEA|UBXD8|UBXN3B | p33MONOX|p60MONOX | |
| Cytomap | 5q35.2 | 5q35.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FAS-associated factor 2UBX domain containing 8UBX domain protein 3BUBX domain-containing protein 3BUBX domain-containing protein 8expressed in T-cells and eosinophils in atopic dermatitis | putative monooxygenase p33MONOXbrain-derived rescue factor p60MONOXflavin monooxygenase motif-containing protein of 33 kDaflavine monooxygenase motif-containing protein of 33 kDap60MONOX brain-derived rescue factor | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q96CS3 | Q96A73 | |
| Ensembl transtripts involved in fusion gene | ENST00000261942, ENST00000510446, | ENST00000298569, ENST00000393728, ENST00000393725, ENST00000510164, ENST00000533553, | |
| Fusion gene scores | * DoF score | 9 X 4 X 3=108 | 7 X 7 X 4=196 |
| # samples | 9 | 7 | |
| ** MAII score | log2(9/108*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAF2 [Title/Abstract] AND KIAA1191 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FAF2(175875471)-KIAA1191(175782752), # samples:2 KIAA1191(175788605)-FAF2(175933769), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FAF2-KIAA1191 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FAF2-KIAA1191 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across FAF2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across KIAA1191 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-57-1582-01A | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| ChimerDB4 | OV | TCGA-57-1582-01A | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| ChimerDB4 | OV | TCGA-57-1582-01A | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| ChimerDB4 | OV | TCGA-57-1582-01A | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
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Fusion Gene ORF analysis for FAF2-KIAA1191 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261942 | ENST00000298569 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| 5CDS-intron | ENST00000261942 | ENST00000393728 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| 5CDS-5UTR | ENST00000261942 | ENST00000393725 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| 5CDS-5UTR | ENST00000261942 | ENST00000510164 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| 5CDS-intron | ENST00000261942 | ENST00000533553 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| intron-3CDS | ENST00000510446 | ENST00000298569 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| intron-intron | ENST00000510446 | ENST00000393728 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| intron-5UTR | ENST00000510446 | ENST00000393725 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| intron-5UTR | ENST00000510446 | ENST00000510164 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| intron-intron | ENST00000510446 | ENST00000533553 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175782752 | - |
| In-frame | ENST00000261942 | ENST00000298569 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| 5CDS-5UTR | ENST00000261942 | ENST00000393728 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| 5CDS-5UTR | ENST00000261942 | ENST00000393725 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| 5CDS-5UTR | ENST00000261942 | ENST00000510164 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| 5CDS-5UTR | ENST00000261942 | ENST00000533553 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| intron-3CDS | ENST00000510446 | ENST00000298569 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| intron-5UTR | ENST00000510446 | ENST00000393728 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| intron-5UTR | ENST00000510446 | ENST00000393725 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| intron-5UTR | ENST00000510446 | ENST00000510164 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| intron-5UTR | ENST00000510446 | ENST00000533553 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - |
| In-frame | ENST00000261942 | ENST00000298569 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| 5CDS-intron | ENST00000261942 | ENST00000393728 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| 5CDS-intron | ENST00000261942 | ENST00000393725 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| 5CDS-intron | ENST00000261942 | ENST00000510164 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| 5CDS-intron | ENST00000261942 | ENST00000533553 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| intron-3CDS | ENST00000510446 | ENST00000298569 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| intron-intron | ENST00000510446 | ENST00000393728 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| intron-intron | ENST00000510446 | ENST00000393725 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| intron-intron | ENST00000510446 | ENST00000510164 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| intron-intron | ENST00000510446 | ENST00000533553 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175779751 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000261942 | FAF2 | chr5 | 175875471 | + | ENST00000298569 | KIAA1191 | chr5 | 175775359 | - | 2114 | 116 | 53 | 574 | 173 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000261942 | ENST00000298569 | FAF2 | chr5 | 175875471 | + | KIAA1191 | chr5 | 175775359 | - | 0.025333844 | 0.97466624 |
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Fusion Genomic Features for FAF2-KIAA1191 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FAF2-KIAA1191 |
| Go to FGviewer for the breakpoints of chr5:175875471-chr5:175775359 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAF2 | KIAA1191 |
| FUNCTION: Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223). {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:24215460, ECO:0000269|PubMed:26692333}. | FUNCTION: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KIAA1191 | chr5:175875471 | chr5:175779751 | ENST00000298569 | 3 | 9 | 67_77 | 69.0 | 306.0 | Motif | Note=Flavin-containing monooxygenase motif | |
| Tgene | KIAA1191 | chr5:175875471 | chr5:175779751 | ENST00000393725 | 2 | 8 | 67_77 | 50.0 | 287.0 | Motif | Note=Flavin-containing monooxygenase motif | |
| Tgene | KIAA1191 | chr5:175875471 | chr5:175779751 | ENST00000510164 | 2 | 8 | 67_77 | 69.0 | 306.0 | Motif | Note=Flavin-containing monooxygenase motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FAF2 | chr5:175875471 | chr5:175775359 | ENST00000261942 | + | 1 | 11 | 275_350 | 21.0 | 446.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | FAF2 | chr5:175875471 | chr5:175779751 | ENST00000261942 | + | 1 | 11 | 275_350 | 21.0 | 446.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | FAF2 | chr5:175875471 | chr5:175775359 | ENST00000261942 | + | 1 | 11 | 12_48 | 21.0 | 446.0 | Domain | Note=UBA |
| Hgene | FAF2 | chr5:175875471 | chr5:175775359 | ENST00000261942 | + | 1 | 11 | 357_439 | 21.0 | 446.0 | Domain | UBX |
| Hgene | FAF2 | chr5:175875471 | chr5:175779751 | ENST00000261942 | + | 1 | 11 | 12_48 | 21.0 | 446.0 | Domain | Note=UBA |
| Hgene | FAF2 | chr5:175875471 | chr5:175779751 | ENST00000261942 | + | 1 | 11 | 357_439 | 21.0 | 446.0 | Domain | UBX |
| Tgene | KIAA1191 | chr5:175875471 | chr5:175775359 | ENST00000298569 | 5 | 9 | 67_77 | 153.0 | 306.0 | Motif | Note=Flavin-containing monooxygenase motif | |
| Tgene | KIAA1191 | chr5:175875471 | chr5:175775359 | ENST00000393725 | 4 | 8 | 67_77 | 134.0 | 287.0 | Motif | Note=Flavin-containing monooxygenase motif | |
| Tgene | KIAA1191 | chr5:175875471 | chr5:175775359 | ENST00000510164 | 4 | 8 | 67_77 | 153.0 | 306.0 | Motif | Note=Flavin-containing monooxygenase motif |
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Fusion Gene Sequence for FAF2-KIAA1191 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000261942_ENST00000298569_TCGA-57-1582-01A_FAF2_chr5_175875471_+_KIAA1191_chr5_175775359_length(transcript)=2114nt_BP=116nt AGTTCCGGCGGGTGACGGTGCGGACGGGTCAGGAGCGTAGAGGCGGCGGCAAAATGGCGGCGCCTGAGGAGCGGGATCTAACCCAGGAGC AGACAGAGAAGCTGCTGCAGTTTCAGAAACTAAAGTTACAGAGTGGAGAGGTAACAAAAGAAGAGAGGCAGCCTGCATCAGCCCAGTCCA CCCCAAGCACCACTCCGCACTCTTCACCTAAGCAGAGGCCCAGGGGCTGGTTCACTTCTGGTTCTTCCACAGCCTTACCTGGCCCAAATC CTAGCACCATGGACTCTGGAAGTGGGGATAAGGACAGAAACTTGTCAGATAAGTGGAGCCTCTTTGGACCGAGATCCCTTCAGAAGTACG ATTCTGGAAGTTTTGCCACCCAGGCCTACCGAGGAGCCCAGAAGCCCTCTCCATTGGAACTGATACGTGCCCAGGCCAACCGAATGGCTG AAGATCCAGCAGCCTTGAAGCCCCCCAAGATGGACATCCCAGTGATGGAAGGAAAGAAACAGCCACCACGGGCCCATAACCTCAAACCCC GTGACCTGAATGTGCTCACACCCACTGGCTTCTAGAGCCCTCTTTCCAGGGATTCTGGTAAAGGTGGTTTCTTGCATCCCACTCCCCTTT TACCTTGGCTTTGACATAGGAAAGGTATATTTAAAAACTTAATCAGCTGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGG CCAAGGTAGGTGGATACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAG CTGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCCTGAACCCAGGAAGCAGATGTTGTACCG AGCTGAGATCATGCCATTACACTCCAGCCTGGGCGACAGAACGAGACGCCATCAATAAATAAATAAATAAAGTAAAGTAAAAAACCTATT AAATTGAGGCTAGAGCTGGAGATGTAATTGGTTTTTGAGAAACATTAGTATAAAGCTTGCCCTTGTTGTGTGGAAGAAGCCATTTTGTAC TGCTTTAAAGTTAGACTAATATTCTCAGCACGGGTGTATGGGGACCTCATTACCTATTTTTTTCATCATTTACCCTAGGTAAGAACTTTG ATCACTGCTTACTAGGTAAAGAATGTTTGTACTGTTCCAAAACCCAGGCTTCTTTATTCCTTTACCACTATCCATGTGAGCATTGACAAA TCATGGCTTAGAGGTGCTCACTGACTCGCTAAGACGACTTTGGCCCTGTTGATGACTGGTGCTGTGCTCCAGCCTTATCAGTTAGGGGAC CCAAGGTTTGTTTGGGACCTGGGTACAGGTAAAAGCCAGACTTGGCAGGGACCCCTCTTTCTAGGCTGAACCTTGAGTCCCCCTGCTTTT TGGCAGACCTAATGGATCACTGTCTTGCAGCTAGTTCTTCATGTGGGGCCTCTTAGGCCAGTGCCGGAGGAGGCATGCTCCTCTTTCTAT GCCACAGAACAAACACTACTCTAGCAGAGCCTTTCTTGCACTTTAAAGTGAGATTAATTTAGCTGTAATTTGGTTAAAAACTTCCTAAGA GAGAAAATTAAGTCTACTGATTTGGTATAGGTAAATGGACATTAAACTTTTTTAAAGTAAAGGAGATGGTAGATACCGTTAGATTATAGT CTTGAGGTTCATGTGAAGCCAGTGGTGTTAACTTACTTTGATTTCCTTGTTCAGGTCAGGGCCTGGAACGCCTGTGCGGGGAGGTCACTC AATTCAAAATTTTCTGTATGAAAGCATTTTTCACCAAAATGAGCCTCATCCCTTTATGCAACACATAACCTTACTGAGGGAGGGAAATAC AGAAGCCACCTTTTTATTTCTCTTCACTGTGTACAAGTTCACTTGTTGTCTTGAACACTGTCTCAAATACCTGCTTTTTGTTTTGGATAG TACCTTGTCTGTATAAGAAGCTGGCCTTTCCATAGAGAGGCCCTGGAGTCTAAAATTATGAGAACAATTAATTTATTTGTGTCTTCTATT >In-frame_ENST00000261942_ENST00000298569_TCGA-57-1582-01A_FAF2_chr5_175875471_+_KIAA1191_chr5_175775359_length(amino acids)=173AA_start in transcript=53_stop in transcript=574 MAAPEERDLTQEQTEKLLQFQKLKLQSGEVTKEERQPASAQSTPSTTPHSSPKQRPRGWFTSGSSTALPGPNPSTMDSGSGDKDRNLSDK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FAF2-KIAA1191 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FAF2-KIAA1191 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FAF2-KIAA1191 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FAF2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | FAF2 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
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