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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM120A-SUSD1 (FusionGDB2 ID:28322)

Fusion Gene Summary for FAM120A-SUSD1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM120A-SUSD1
Fusion gene ID: 28322
HgeneTgene
Gene symbol

FAM120A

SUSD1

Gene ID

23196

64420

Gene namefamily with sequence similarity 120Asushi domain containing 1
SynonymsC9orf10|HBVPTPAP|OSSA-
Cytomap

9q22.31

9q31.3-q32

Type of geneprotein-codingprotein-coding
Descriptionconstitutive coactivator of PPAR-gamma-like protein 1oxidative stess-associated Src activatoroxidative stress-associated Src activatorsushi domain-containing protein 1
Modification date2020032020200313
UniProtAcc

Q9NZB2

.
Ensembl transtripts involved in fusion geneENST00000277165, ENST00000375389, 
ENST00000340893, ENST00000333936, 
ENST00000475933, 		ENST00000374263, 
ENST00000374270, ENST00000374264, 
ENST00000482851, 
Fusion gene scores* DoF score10 X 9 X 4=36011 X 9 X 6=594
# samples 1213
** MAII scorelog2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/594*10)=-2.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM120A [Title/Abstract] AND SUSD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM120A(96289524)-SUSD1(114804240), # samples:3
Anticipated loss of major functional domain due to fusion event.FAM120A-SUSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM120A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SUSD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AATS-01AFAM120Achr9

96289524

+SUSD1chr9

114804240

-
ChimerDB4SARCTCGA-DX-A48K-01AFAM120Achr9

96289524

+SUSD1chr9

114804240

-
ChimerDB4SARCTCGA-DX-AATS-01AFAM120Achr9

96289524

-SUSD1chr9

114804240

-


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Fusion Gene ORF analysis for FAM120A-SUSD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000277165ENST00000374263FAM120Achr9

96289524

+SUSD1chr9

114804240

-
Frame-shiftENST00000277165ENST00000374270FAM120Achr9

96289524

+SUSD1chr9

114804240

-
In-frameENST00000277165ENST00000374264FAM120Achr9

96289524

+SUSD1chr9

114804240

-
5CDS-intronENST00000277165ENST00000482851FAM120Achr9

96289524

+SUSD1chr9

114804240

-
In-frameENST00000375389ENST00000374263FAM120Achr9

96289524

+SUSD1chr9

114804240

-
Frame-shiftENST00000375389ENST00000374270FAM120Achr9

96289524

+SUSD1chr9

114804240

-
In-frameENST00000375389ENST00000374264FAM120Achr9

96289524

+SUSD1chr9

114804240

-
5CDS-intronENST00000375389ENST00000482851FAM120Achr9

96289524

+SUSD1chr9

114804240

-
In-frameENST00000340893ENST00000374263FAM120Achr9

96289524

+SUSD1chr9

114804240

-
Frame-shiftENST00000340893ENST00000374270FAM120Achr9

96289524

+SUSD1chr9

114804240

-
In-frameENST00000340893ENST00000374264FAM120Achr9

96289524

+SUSD1chr9

114804240

-
5CDS-intronENST00000340893ENST00000482851FAM120Achr9

96289524

+SUSD1chr9

114804240

-
In-frameENST00000333936ENST00000374263FAM120Achr9

96289524

+SUSD1chr9

114804240

-
Frame-shiftENST00000333936ENST00000374270FAM120Achr9

96289524

+SUSD1chr9

114804240

-
In-frameENST00000333936ENST00000374264FAM120Achr9

96289524

+SUSD1chr9

114804240

-
5CDS-intronENST00000333936ENST00000482851FAM120Achr9

96289524

+SUSD1chr9

114804240

-
intron-3CDSENST00000475933ENST00000374263FAM120Achr9

96289524

+SUSD1chr9

114804240

-
intron-3CDSENST00000475933ENST00000374270FAM120Achr9

96289524

+SUSD1chr9

114804240

-
intron-3CDSENST00000475933ENST00000374264FAM120Achr9

96289524

+SUSD1chr9

114804240

-
intron-intronENST00000475933ENST00000482851FAM120Achr9

96289524

+SUSD1chr9

114804240

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000277165FAM120Achr996289524+ENST00000374263SUSD1chr9114804240-250217001941759521
ENST00000277165FAM120Achr996289524+ENST00000374264SUSD1chr9114804240-220817001941759521
ENST00000375389FAM120Achr996289524+ENST00000374263SUSD1chr9114804240-23331531251590521
ENST00000375389FAM120Achr996289524+ENST00000374264SUSD1chr9114804240-20391531251590521
ENST00000340893FAM120Achr996289524+ENST00000374263SUSD1chr9114804240-23331531251590521
ENST00000340893FAM120Achr996289524+ENST00000374264SUSD1chr9114804240-20391531251590521
ENST00000333936FAM120Achr996289524+ENST00000374263SUSD1chr9114804240-24171615251674549
ENST00000333936FAM120Achr996289524+ENST00000374264SUSD1chr9114804240-21231615251674549

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000277165ENST00000374263FAM120Achr996289524+SUSD1chr9114804240-0.0116200960.98837996
ENST00000277165ENST00000374264FAM120Achr996289524+SUSD1chr9114804240-0.0133251110.98667485
ENST00000375389ENST00000374263FAM120Achr996289524+SUSD1chr9114804240-0.0121252350.9878748
ENST00000375389ENST00000374264FAM120Achr996289524+SUSD1chr9114804240-0.0142738880.9857261
ENST00000340893ENST00000374263FAM120Achr996289524+SUSD1chr9114804240-0.0121252350.9878748
ENST00000340893ENST00000374264FAM120Achr996289524+SUSD1chr9114804240-0.0142738880.9857261
ENST00000333936ENST00000374263FAM120Achr996289524+SUSD1chr9114804240-0.0119336290.9880663
ENST00000333936ENST00000374264FAM120Achr996289524+SUSD1chr9114804240-0.0142689650.98573107

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Fusion Genomic Features for FAM120A-SUSD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM120A-SUSD1


check button Go to

FGviewer for the breakpoints of chr9:96289524-chr9:114804240

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM120A

Q9NZB2

.
FUNCTION: May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. {ECO:0000250, ECO:0000269|PubMed:19015244}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742641518743_747738.0844.3333333333334Topological domainCytoplasmic
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742701417743_747716.3333333333334748.0Topological domainCytoplasmic
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742701417722_742716.3333333333334748.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM120Achr9:96289524chr9:114804240ENST00000277165+818829_1118502.01119.0RegionNote=RNA binding
HgeneFAM120Achr9:96289524chr9:114804240ENST00000333936+919829_1118530.01147.0RegionNote=RNA binding
HgeneFAM120Achr9:96289524chr9:114804240ENST00000340893+817829_1118502.01073.0RegionNote=RNA binding
HgeneFAM120Achr9:96289524chr9:114804240ENST00000375389+89829_1118502.0629.0RegionNote=RNA binding
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742641518125_162738.0844.3333333333334DomainEGF-like 3%3B calcium-binding
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742641518177_236738.0844.3333333333334DomainSushi 1
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742641518237_296738.0844.3333333333334DomainSushi 2
TgeneSUSD1chr9:96289524chr9:114804240ENST00000374264151835_72738.0844.3333333333334DomainEGF-like 1
TgeneSUSD1chr9:96289524chr9:114804240ENST00000374264151873_112738.0844.3333333333334DomainEGF-like 2%3B calcium-binding
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742701417125_162716.3333333333334748.0DomainEGF-like 3%3B calcium-binding
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742701417177_236716.3333333333334748.0DomainSushi 1
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742701417237_296716.3333333333334748.0DomainSushi 2
TgeneSUSD1chr9:96289524chr9:114804240ENST00000374270141735_72716.3333333333334748.0DomainEGF-like 1
TgeneSUSD1chr9:96289524chr9:114804240ENST00000374270141773_112716.3333333333334748.0DomainEGF-like 2%3B calcium-binding
TgeneSUSD1chr9:96289524chr9:114804240ENST00000374264151830_721738.0844.3333333333334Topological domainExtracellular
TgeneSUSD1chr9:96289524chr9:114804240ENST00000374270141730_721716.3333333333334748.0Topological domainExtracellular
TgeneSUSD1chr9:96289524chr9:114804240ENST000003742641518722_742738.0844.3333333333334TransmembraneHelical


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Fusion Gene Sequence for FAM120A-SUSD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000277165_ENST00000374263_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(transcript)=2502nt_BP=1700nt
GTCCCTCCCCAGACATGGCCCTGGGAGGCGGCAGCACATGGCGGCCGCGGCGGCCATGAGCGCGCCCCCGACCCGCCCCAGTCCCCCCTA
GAGGCCGCCGCCCCCGCCCGCCAGCCCGCCCGCGCGCCACGGCCCCACCACCCCCGGCCCCGCCGCCCCCCGCCCGCACCCGCGCCCGCG
CCCCCGCCGCCGCCATGGGCGTGCAGGGCTTCCAGGACTACATCGAGAAGCACTGCCCGAGCGCCGTGGTGCCGGTGGAGCTGCAGAAGC
TGGCCCGGGGCAGCCTGGTGGGCGGCGGGCGGCAGCGGCCCCCGCAGACCCCGCTGCGCCTGCTGGTGGACGCCGACAACTGCCTGCACC
GCCTCTACGGCGGCTTCTACACCGACTGGGTCAGCGGCGGCCAGTGGAACCACATGCTTGGCTACCTGGCGGCGCTGGCCAAGGCCTGCT
TCGGCGGCAACATCGAGCTCTTCGTCTTCTTCAACGGCGCGCTCGAGAAGGCCCGGCTGCACGAGTGGGTCAAGCGGCAGGGCAACGAGC
GCCAGACGGCACAGCAGATCGTCAGCCATGTCCAGAACAAGGGCACCCCGCCGCCAAAGGTCTGGTTCCTGCCGCCCGTCTGCATGGCCC
ACTGCATCCGCCTGGCGCTCATCCGCTTCCACGTCAAGGTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGGTTTCTGCAGAG
AGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGCCCTAAAACTGA
GCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCGTTTTCCTATTT
TTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACATCCACTAGCCT
CACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAACATTCAGGACA
CCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAAGAGAGCAATTG
GATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAGCAGCCAGACCCGGTCCGTTTGGAATGCCTGGGATGG
TGCCGCCGCATGTTCCTCCTCAGATGCTCAACATTCCGCAGACCTCTCTGCAAGCAAAGCCCGTGGCCCCACAGGTGCCCAGCCCAGGGG
GCGCCCCGGGCCAGGGTCCATACCCGTACAGCCTCTCTGAGCCAGCACCTCTCACTTTGGACACGAGCGGGAAGAATCTGACGGAGCAGA
ACAGCTACAGCAACATTCCTCACGAAGGGAAGCACACGCCGCTGTATGAGCGGTCCTCGCCCATCAACCCGGCCCAGAGCGGCAGCCCCA
ACCACGTGGATTCCGCCTACTTCCCTGGCTCTTCTACATCGTCATCTTCCGACAACGACGAGGGCAGCGGAGGGGCGACAAACCATATCA
GCGGGAACAAGATTGGCTGGGAGAAGACGGGAAGCCACTCAGAGCCTCAGGCACGAGGAGACCCAGGAGACCAAACAAAGATTCGTCACT
CATGCTGCTGCAGATGGCGGGTGTTGGACTGGGTTCCCTGGCTGTTGTGATCATTCTCACATTCCTCTCCTTCTCAGCGGTGTGATGGCA
GATGGACACTGAGTGGGGAGGATGCACTGCTGCTGGGCAGGTGTTCTGGCAGCTTCTCAGGTGCCCGCACAGAGGCTCCGTGTGACTTCC
GTCCAGGGAGCATGTGGGCCTGCAACTTTCTCCATTCCCAGCTGGGCCCCATTCCTGGATTTAAGATGGTGGCTATCCCTGAGGAGTCAC
CATAAGGAGAAAACTCAGGAATTCTGAGTCTTCCCTGCTACAGGACCAGTTCTGTGCAATGAACTTGAGACTCCTGATGTACACTGTGAT
ATTGACCGAAGGCTACATACAGATCTGTGAATCTTGGCTGGGACTTCCTCTGAGTGATGCCTGAGGGTCAGCTCCTCTAGACATTGACTG
CAAGAGAATCTCTGCAACCTCCTATATAAAAGCATTTCTGTTAATTCATTCAGAATCCATTCTTTACAATATGCAGTGAGATGGGCTTAA
GTTTGGGCTAGAGTTTGACTTTATGAAGGAGGTCATTGAAAAAGAGAACAGTGACGTAGGCAAATGTTTCAAGCACTTTAGAAACAGTAC
TTTTCCTATAATTAGTTGATATACTAATGAGAAAATATACTAGCCTGGCCATGCCAATAAGTTTCCTGCTGTGTCTGTTAGGCAGCATTG

>In-frame_ENST00000277165_ENST00000374263_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(amino acids)=521AA_start in transcript=194_stop in transcript=1759
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNI
ELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVR
AHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHV
PPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDS

--------------------------------------------------------------
>In-frame_ENST00000277165_ENST00000374264_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(transcript)=2208nt_BP=1700nt
GTCCCTCCCCAGACATGGCCCTGGGAGGCGGCAGCACATGGCGGCCGCGGCGGCCATGAGCGCGCCCCCGACCCGCCCCAGTCCCCCCTA
GAGGCCGCCGCCCCCGCCCGCCAGCCCGCCCGCGCGCCACGGCCCCACCACCCCCGGCCCCGCCGCCCCCCGCCCGCACCCGCGCCCGCG
CCCCCGCCGCCGCCATGGGCGTGCAGGGCTTCCAGGACTACATCGAGAAGCACTGCCCGAGCGCCGTGGTGCCGGTGGAGCTGCAGAAGC
TGGCCCGGGGCAGCCTGGTGGGCGGCGGGCGGCAGCGGCCCCCGCAGACCCCGCTGCGCCTGCTGGTGGACGCCGACAACTGCCTGCACC
GCCTCTACGGCGGCTTCTACACCGACTGGGTCAGCGGCGGCCAGTGGAACCACATGCTTGGCTACCTGGCGGCGCTGGCCAAGGCCTGCT
TCGGCGGCAACATCGAGCTCTTCGTCTTCTTCAACGGCGCGCTCGAGAAGGCCCGGCTGCACGAGTGGGTCAAGCGGCAGGGCAACGAGC
GCCAGACGGCACAGCAGATCGTCAGCCATGTCCAGAACAAGGGCACCCCGCCGCCAAAGGTCTGGTTCCTGCCGCCCGTCTGCATGGCCC
ACTGCATCCGCCTGGCGCTCATCCGCTTCCACGTCAAGGTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGGTTTCTGCAGAG
AGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGCCCTAAAACTGA
GCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCGTTTTCCTATTT
TTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACATCCACTAGCCT
CACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAACATTCAGGACA
CCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAAGAGAGCAATTG
GATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAGCAGCCAGACCCGGTCCGTTTGGAATGCCTGGGATGG
TGCCGCCGCATGTTCCTCCTCAGATGCTCAACATTCCGCAGACCTCTCTGCAAGCAAAGCCCGTGGCCCCACAGGTGCCCAGCCCAGGGG
GCGCCCCGGGCCAGGGTCCATACCCGTACAGCCTCTCTGAGCCAGCACCTCTCACTTTGGACACGAGCGGGAAGAATCTGACGGAGCAGA
ACAGCTACAGCAACATTCCTCACGAAGGGAAGCACACGCCGCTGTATGAGCGGTCCTCGCCCATCAACCCGGCCCAGAGCGGCAGCCCCA
ACCACGTGGATTCCGCCTACTTCCCTGGCTCTTCTACATCGTCATCTTCCGACAACGACGAGGGCAGCGGAGGGGCGACAAACCATATCA
GCGGGAACAAGATTGGCTGGGAGAAGACGGGAAGCCACTCAGAGCCTCAGGCACGAGGAGACCCAGGAGACCAAACAAAGATTCGTCACT
CATGCTGCTGCAGATGGCGGGTGTTGGACTGGGTTCCCTGGCTGTTGTGATCATTCTCACATTCCTCTCCTTCTCAGCGGTGTGATGGCA
GATGGACACTGAGTGGGGAGGATGCACTGCTGCTGGGCAGGTGTTCTGGCAGCTTCTCAGGTGCCCGCACAGAGGCTCCGTGTGACTTCC
GTCCAGGGAGCATGTGGGCCTGCAACTTTCTCCATTCCCAGCTGGGCCCCATTCCTGGATTTAAGATGGTGGCTATCCCTGAGGAGTCAC
CATAAGGAGAAAACTCAGGAATTCTGAGTCTTCCCTGCTACAGGACCAGTTCTGTGCAATGAACTTGAGACTCCTGATGTACACTGTGAT
ATTGACCGAAGGCTACATACAGATCTGTGAATCTTGGCTGGGACTTCCTCTGAGTGATGCCTGAGGGTCAGCTCCTCTAGACATTGACTG

>In-frame_ENST00000277165_ENST00000374264_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(amino acids)=521AA_start in transcript=194_stop in transcript=1759
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNI
ELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVR
AHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHV
PPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDS

--------------------------------------------------------------
>In-frame_ENST00000375389_ENST00000374263_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(transcript)=2333nt_BP=1531nt
CCGCGCCCGCGCCCCCGCCGCCGCCATGGGCGTGCAGGGCTTCCAGGACTACATCGAGAAGCACTGCCCGAGCGCCGTGGTGCCGGTGGA
GCTGCAGAAGCTGGCCCGGGGCAGCCTGGTGGGCGGCGGGCGGCAGCGGCCCCCGCAGACCCCGCTGCGCCTGCTGGTGGACGCCGACAA
CTGCCTGCACCGCCTCTACGGCGGCTTCTACACCGACTGGGTCAGCGGCGGCCAGTGGAACCACATGCTTGGCTACCTGGCGGCGCTGGC
CAAGGCCTGCTTCGGCGGCAACATCGAGCTCTTCGTCTTCTTCAACGGCGCGCTCGAGAAGGCCCGGCTGCACGAGTGGGTCAAGCGGCA
GGGCAACGAGCGCCAGACGGCACAGCAGATCGTCAGCCATGTCCAGAACAAGGGCACCCCGCCGCCAAAGGTCTGGTTCCTGCCGCCCGT
CTGCATGGCCCACTGCATCCGCCTGGCGCTCATCCGCTTCCACGTCAAGGTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGG
TTTCTGCAGAGAGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGC
CCTAAAACTGAGCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCG
TTTTCCTATTTTTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACA
TCCACTAGCCTCACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAA
CATTCAGGACACCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAA
GAGAGCAATTGGATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAGCAGCCAGACCCGGTCCGTTTGGAAT
GCCTGGGATGGTGCCGCCGCATGTTCCTCCTCAGATGCTCAACATTCCGCAGACCTCTCTGCAAGCAAAGCCCGTGGCCCCACAGGTGCC
CAGCCCAGGGGGCGCCCCGGGCCAGGGTCCATACCCGTACAGCCTCTCTGAGCCAGCACCTCTCACTTTGGACACGAGCGGGAAGAATCT
GACGGAGCAGAACAGCTACAGCAACATTCCTCACGAAGGGAAGCACACGCCGCTGTATGAGCGGTCCTCGCCCATCAACCCGGCCCAGAG
CGGCAGCCCCAACCACGTGGATTCCGCCTACTTCCCTGGCTCTTCTACATCGTCATCTTCCGACAACGACGAGGGCAGCGGAGGGGCGAC
AAACCATATCAGCGGGAACAAGATTGGCTGGGAGAAGACGGGAAGCCACTCAGAGCCTCAGGCACGAGGAGACCCAGGAGACCAAACAAA
GATTCGTCACTCATGCTGCTGCAGATGGCGGGTGTTGGACTGGGTTCCCTGGCTGTTGTGATCATTCTCACATTCCTCTCCTTCTCAGCG
GTGTGATGGCAGATGGACACTGAGTGGGGAGGATGCACTGCTGCTGGGCAGGTGTTCTGGCAGCTTCTCAGGTGCCCGCACAGAGGCTCC
GTGTGACTTCCGTCCAGGGAGCATGTGGGCCTGCAACTTTCTCCATTCCCAGCTGGGCCCCATTCCTGGATTTAAGATGGTGGCTATCCC
TGAGGAGTCACCATAAGGAGAAAACTCAGGAATTCTGAGTCTTCCCTGCTACAGGACCAGTTCTGTGCAATGAACTTGAGACTCCTGATG
TACACTGTGATATTGACCGAAGGCTACATACAGATCTGTGAATCTTGGCTGGGACTTCCTCTGAGTGATGCCTGAGGGTCAGCTCCTCTA
GACATTGACTGCAAGAGAATCTCTGCAACCTCCTATATAAAAGCATTTCTGTTAATTCATTCAGAATCCATTCTTTACAATATGCAGTGA
GATGGGCTTAAGTTTGGGCTAGAGTTTGACTTTATGAAGGAGGTCATTGAAAAAGAGAACAGTGACGTAGGCAAATGTTTCAAGCACTTT
AGAAACAGTACTTTTCCTATAATTAGTTGATATACTAATGAGAAAATATACTAGCCTGGCCATGCCAATAAGTTTCCTGCTGTGTCTGTT

>In-frame_ENST00000375389_ENST00000374263_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(amino acids)=521AA_start in transcript=25_stop in transcript=1590
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNI
ELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVR
AHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHV
PPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDS

--------------------------------------------------------------
>In-frame_ENST00000375389_ENST00000374264_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(transcript)=2039nt_BP=1531nt
CCGCGCCCGCGCCCCCGCCGCCGCCATGGGCGTGCAGGGCTTCCAGGACTACATCGAGAAGCACTGCCCGAGCGCCGTGGTGCCGGTGGA
GCTGCAGAAGCTGGCCCGGGGCAGCCTGGTGGGCGGCGGGCGGCAGCGGCCCCCGCAGACCCCGCTGCGCCTGCTGGTGGACGCCGACAA
CTGCCTGCACCGCCTCTACGGCGGCTTCTACACCGACTGGGTCAGCGGCGGCCAGTGGAACCACATGCTTGGCTACCTGGCGGCGCTGGC
CAAGGCCTGCTTCGGCGGCAACATCGAGCTCTTCGTCTTCTTCAACGGCGCGCTCGAGAAGGCCCGGCTGCACGAGTGGGTCAAGCGGCA
GGGCAACGAGCGCCAGACGGCACAGCAGATCGTCAGCCATGTCCAGAACAAGGGCACCCCGCCGCCAAAGGTCTGGTTCCTGCCGCCCGT
CTGCATGGCCCACTGCATCCGCCTGGCGCTCATCCGCTTCCACGTCAAGGTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGG
TTTCTGCAGAGAGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGC
CCTAAAACTGAGCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCG
TTTTCCTATTTTTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACA
TCCACTAGCCTCACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAA
CATTCAGGACACCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAA
GAGAGCAATTGGATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAGCAGCCAGACCCGGTCCGTTTGGAAT
GCCTGGGATGGTGCCGCCGCATGTTCCTCCTCAGATGCTCAACATTCCGCAGACCTCTCTGCAAGCAAAGCCCGTGGCCCCACAGGTGCC
CAGCCCAGGGGGCGCCCCGGGCCAGGGTCCATACCCGTACAGCCTCTCTGAGCCAGCACCTCTCACTTTGGACACGAGCGGGAAGAATCT
GACGGAGCAGAACAGCTACAGCAACATTCCTCACGAAGGGAAGCACACGCCGCTGTATGAGCGGTCCTCGCCCATCAACCCGGCCCAGAG
CGGCAGCCCCAACCACGTGGATTCCGCCTACTTCCCTGGCTCTTCTACATCGTCATCTTCCGACAACGACGAGGGCAGCGGAGGGGCGAC
AAACCATATCAGCGGGAACAAGATTGGCTGGGAGAAGACGGGAAGCCACTCAGAGCCTCAGGCACGAGGAGACCCAGGAGACCAAACAAA
GATTCGTCACTCATGCTGCTGCAGATGGCGGGTGTTGGACTGGGTTCCCTGGCTGTTGTGATCATTCTCACATTCCTCTCCTTCTCAGCG
GTGTGATGGCAGATGGACACTGAGTGGGGAGGATGCACTGCTGCTGGGCAGGTGTTCTGGCAGCTTCTCAGGTGCCCGCACAGAGGCTCC
GTGTGACTTCCGTCCAGGGAGCATGTGGGCCTGCAACTTTCTCCATTCCCAGCTGGGCCCCATTCCTGGATTTAAGATGGTGGCTATCCC
TGAGGAGTCACCATAAGGAGAAAACTCAGGAATTCTGAGTCTTCCCTGCTACAGGACCAGTTCTGTGCAATGAACTTGAGACTCCTGATG
TACACTGTGATATTGACCGAAGGCTACATACAGATCTGTGAATCTTGGCTGGGACTTCCTCTGAGTGATGCCTGAGGGTCAGCTCCTCTA

>In-frame_ENST00000375389_ENST00000374264_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(amino acids)=521AA_start in transcript=25_stop in transcript=1590
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNI
ELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVR
AHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHV
PPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDS

--------------------------------------------------------------
>In-frame_ENST00000340893_ENST00000374263_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(transcript)=2333nt_BP=1531nt
CCGCGCCCGCGCCCCCGCCGCCGCCATGGGCGTGCAGGGCTTCCAGGACTACATCGAGAAGCACTGCCCGAGCGCCGTGGTGCCGGTGGA
GCTGCAGAAGCTGGCCCGGGGCAGCCTGGTGGGCGGCGGGCGGCAGCGGCCCCCGCAGACCCCGCTGCGCCTGCTGGTGGACGCCGACAA
CTGCCTGCACCGCCTCTACGGCGGCTTCTACACCGACTGGGTCAGCGGCGGCCAGTGGAACCACATGCTTGGCTACCTGGCGGCGCTGGC
CAAGGCCTGCTTCGGCGGCAACATCGAGCTCTTCGTCTTCTTCAACGGCGCGCTCGAGAAGGCCCGGCTGCACGAGTGGGTCAAGCGGCA
GGGCAACGAGCGCCAGACGGCACAGCAGATCGTCAGCCATGTCCAGAACAAGGGCACCCCGCCGCCAAAGGTCTGGTTCCTGCCGCCCGT
CTGCATGGCCCACTGCATCCGCCTGGCGCTCATCCGCTTCCACGTCAAGGTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGG
TTTCTGCAGAGAGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGC
CCTAAAACTGAGCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCG
TTTTCCTATTTTTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACA
TCCACTAGCCTCACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAA
CATTCAGGACACCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAA
GAGAGCAATTGGATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAGCAGCCAGACCCGGTCCGTTTGGAAT
GCCTGGGATGGTGCCGCCGCATGTTCCTCCTCAGATGCTCAACATTCCGCAGACCTCTCTGCAAGCAAAGCCCGTGGCCCCACAGGTGCC
CAGCCCAGGGGGCGCCCCGGGCCAGGGTCCATACCCGTACAGCCTCTCTGAGCCAGCACCTCTCACTTTGGACACGAGCGGGAAGAATCT
GACGGAGCAGAACAGCTACAGCAACATTCCTCACGAAGGGAAGCACACGCCGCTGTATGAGCGGTCCTCGCCCATCAACCCGGCCCAGAG
CGGCAGCCCCAACCACGTGGATTCCGCCTACTTCCCTGGCTCTTCTACATCGTCATCTTCCGACAACGACGAGGGCAGCGGAGGGGCGAC
AAACCATATCAGCGGGAACAAGATTGGCTGGGAGAAGACGGGAAGCCACTCAGAGCCTCAGGCACGAGGAGACCCAGGAGACCAAACAAA
GATTCGTCACTCATGCTGCTGCAGATGGCGGGTGTTGGACTGGGTTCCCTGGCTGTTGTGATCATTCTCACATTCCTCTCCTTCTCAGCG
GTGTGATGGCAGATGGACACTGAGTGGGGAGGATGCACTGCTGCTGGGCAGGTGTTCTGGCAGCTTCTCAGGTGCCCGCACAGAGGCTCC
GTGTGACTTCCGTCCAGGGAGCATGTGGGCCTGCAACTTTCTCCATTCCCAGCTGGGCCCCATTCCTGGATTTAAGATGGTGGCTATCCC
TGAGGAGTCACCATAAGGAGAAAACTCAGGAATTCTGAGTCTTCCCTGCTACAGGACCAGTTCTGTGCAATGAACTTGAGACTCCTGATG
TACACTGTGATATTGACCGAAGGCTACATACAGATCTGTGAATCTTGGCTGGGACTTCCTCTGAGTGATGCCTGAGGGTCAGCTCCTCTA
GACATTGACTGCAAGAGAATCTCTGCAACCTCCTATATAAAAGCATTTCTGTTAATTCATTCAGAATCCATTCTTTACAATATGCAGTGA
GATGGGCTTAAGTTTGGGCTAGAGTTTGACTTTATGAAGGAGGTCATTGAAAAAGAGAACAGTGACGTAGGCAAATGTTTCAAGCACTTT
AGAAACAGTACTTTTCCTATAATTAGTTGATATACTAATGAGAAAATATACTAGCCTGGCCATGCCAATAAGTTTCCTGCTGTGTCTGTT

>In-frame_ENST00000340893_ENST00000374263_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(amino acids)=521AA_start in transcript=25_stop in transcript=1590
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNI
ELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVR
AHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHV
PPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDS

--------------------------------------------------------------
>In-frame_ENST00000340893_ENST00000374264_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(transcript)=2039nt_BP=1531nt
CCGCGCCCGCGCCCCCGCCGCCGCCATGGGCGTGCAGGGCTTCCAGGACTACATCGAGAAGCACTGCCCGAGCGCCGTGGTGCCGGTGGA
GCTGCAGAAGCTGGCCCGGGGCAGCCTGGTGGGCGGCGGGCGGCAGCGGCCCCCGCAGACCCCGCTGCGCCTGCTGGTGGACGCCGACAA
CTGCCTGCACCGCCTCTACGGCGGCTTCTACACCGACTGGGTCAGCGGCGGCCAGTGGAACCACATGCTTGGCTACCTGGCGGCGCTGGC
CAAGGCCTGCTTCGGCGGCAACATCGAGCTCTTCGTCTTCTTCAACGGCGCGCTCGAGAAGGCCCGGCTGCACGAGTGGGTCAAGCGGCA
GGGCAACGAGCGCCAGACGGCACAGCAGATCGTCAGCCATGTCCAGAACAAGGGCACCCCGCCGCCAAAGGTCTGGTTCCTGCCGCCCGT
CTGCATGGCCCACTGCATCCGCCTGGCGCTCATCCGCTTCCACGTCAAGGTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGG
TTTCTGCAGAGAGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGC
CCTAAAACTGAGCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCG
TTTTCCTATTTTTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACA
TCCACTAGCCTCACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAA
CATTCAGGACACCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAA
GAGAGCAATTGGATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAGCAGCCAGACCCGGTCCGTTTGGAAT
GCCTGGGATGGTGCCGCCGCATGTTCCTCCTCAGATGCTCAACATTCCGCAGACCTCTCTGCAAGCAAAGCCCGTGGCCCCACAGGTGCC
CAGCCCAGGGGGCGCCCCGGGCCAGGGTCCATACCCGTACAGCCTCTCTGAGCCAGCACCTCTCACTTTGGACACGAGCGGGAAGAATCT
GACGGAGCAGAACAGCTACAGCAACATTCCTCACGAAGGGAAGCACACGCCGCTGTATGAGCGGTCCTCGCCCATCAACCCGGCCCAGAG
CGGCAGCCCCAACCACGTGGATTCCGCCTACTTCCCTGGCTCTTCTACATCGTCATCTTCCGACAACGACGAGGGCAGCGGAGGGGCGAC
AAACCATATCAGCGGGAACAAGATTGGCTGGGAGAAGACGGGAAGCCACTCAGAGCCTCAGGCACGAGGAGACCCAGGAGACCAAACAAA
GATTCGTCACTCATGCTGCTGCAGATGGCGGGTGTTGGACTGGGTTCCCTGGCTGTTGTGATCATTCTCACATTCCTCTCCTTCTCAGCG
GTGTGATGGCAGATGGACACTGAGTGGGGAGGATGCACTGCTGCTGGGCAGGTGTTCTGGCAGCTTCTCAGGTGCCCGCACAGAGGCTCC
GTGTGACTTCCGTCCAGGGAGCATGTGGGCCTGCAACTTTCTCCATTCCCAGCTGGGCCCCATTCCTGGATTTAAGATGGTGGCTATCCC
TGAGGAGTCACCATAAGGAGAAAACTCAGGAATTCTGAGTCTTCCCTGCTACAGGACCAGTTCTGTGCAATGAACTTGAGACTCCTGATG
TACACTGTGATATTGACCGAAGGCTACATACAGATCTGTGAATCTTGGCTGGGACTTCCTCTGAGTGATGCCTGAGGGTCAGCTCCTCTA

>In-frame_ENST00000340893_ENST00000374264_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(amino acids)=521AA_start in transcript=25_stop in transcript=1590
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNI
ELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVR
AHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHV
PPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDS

--------------------------------------------------------------
>In-frame_ENST00000333936_ENST00000374263_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(transcript)=2417nt_BP=1615nt
CCGCGCCCGCGCCCCCGCCGCCGCCATGGGCGTGCAGGGCTTCCAGGACTACATCGAGAAGCACTGCCCGAGCGCCGTGGTGCCGGTGGA
GCTGCAGAAGCTGGCCCGGGGCAGCCTGGTGGGCGGCGGGCGGCAGCGGCCCCCGCAGACCCCGCTGCGCCTGCTGGTGGACGCCGACAA
CTGCCTGCACCGCCTCTACGGCGGCTTCTACACCGACTGGGTCAGCGGCGGCCAGTGGAACCACATGCTTGGCTACCTGGCGGCGCTGGC
CAAGGCCTGCTTCGGCGGCAACATCGAGCTCTTCGTCTTCTTCAACGGCGCGCTCGAGAAGGCCCGGCTGCACGAGTGGGTCAAGCGGCA
GGGCAACGAGCGCCAGACGGCACAGCAGATCGTCAGCCATGTCCAGAACAAGGGCACCCCGCCGCCAAAGGTCTGGTTCCTGCCGCCCGT
CTGCATGGCCCACTGCATCCGCCTGGCGCTCATCCGCTTCCACGTCAAGGTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGG
TTTCTGCAGAGAGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGC
CCTAAAACTGAGCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCG
TTTTCCTATTTTTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACA
TCCACTAGCCTCACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAA
CATTCAGGACACCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAA
GAGAGCAATTGGATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAGCAGCCAGACCCGGTCCGTTTGGAAT
GCCTGGGATGGTGCCGCCGCATGTTCCTCCTCAGATGCTCAACATTCCGCAGACCTCTCTGCAAGCAAAGCCCGTGGCCCCACAGGTGCC
CAGCCCAGGGGGCGCCCCGGGCCAGGGTCCATACCCGTACAGCCTCTCTGAGCCAGCACCTCTCACTTTGGACACGAGCGGGAAGAATCT
GACGGAGCAGAACAGCTACAGCAACATTCCTCACGAAGGGAAGCACACGCCGCTGTATGAGCGGTCCTCGCCCATCAACCCGGCCCAGAG
CGGCAGCCCCAACCACGTGGATTCCGCCTACTTCCCTGGCTCTTCTACATCGTCATCTTCCGACAACGACGAGGGCAGCGGAGGGGCGAC
AAAGCCTTTCCAACTCTACTTGCAAAAAAACTTTGTGTTTCACAAAGAGAATTCCATCGTGCTCTGCTCCAGGATCCTGAGGCATGGCCA
TATCAGCGGGAACAAGATTGGCTGGGAGAAGACGGGAAGCCACTCAGAGCCTCAGGCACGAGGAGACCCAGGAGACCAAACAAAGATTCG
TCACTCATGCTGCTGCAGATGGCGGGTGTTGGACTGGGTTCCCTGGCTGTTGTGATCATTCTCACATTCCTCTCCTTCTCAGCGGTGTGA
TGGCAGATGGACACTGAGTGGGGAGGATGCACTGCTGCTGGGCAGGTGTTCTGGCAGCTTCTCAGGTGCCCGCACAGAGGCTCCGTGTGA
CTTCCGTCCAGGGAGCATGTGGGCCTGCAACTTTCTCCATTCCCAGCTGGGCCCCATTCCTGGATTTAAGATGGTGGCTATCCCTGAGGA
GTCACCATAAGGAGAAAACTCAGGAATTCTGAGTCTTCCCTGCTACAGGACCAGTTCTGTGCAATGAACTTGAGACTCCTGATGTACACT
GTGATATTGACCGAAGGCTACATACAGATCTGTGAATCTTGGCTGGGACTTCCTCTGAGTGATGCCTGAGGGTCAGCTCCTCTAGACATT
GACTGCAAGAGAATCTCTGCAACCTCCTATATAAAAGCATTTCTGTTAATTCATTCAGAATCCATTCTTTACAATATGCAGTGAGATGGG
CTTAAGTTTGGGCTAGAGTTTGACTTTATGAAGGAGGTCATTGAAAAAGAGAACAGTGACGTAGGCAAATGTTTCAAGCACTTTAGAAAC
AGTACTTTTCCTATAATTAGTTGATATACTAATGAGAAAATATACTAGCCTGGCCATGCCAATAAGTTTCCTGCTGTGTCTGTTAGGCAG

>In-frame_ENST00000333936_ENST00000374263_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(amino acids)=549AA_start in transcript=25_stop in transcript=1674
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNI
ELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVR
AHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHV
PPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDS
AYFPGSSTSSSSDNDEGSGGATKPFQLYLQKNFVFHKENSIVLCSRILRHGHISGNKIGWEKTGSHSEPQARGDPGDQTKIRHSCCCRWR

--------------------------------------------------------------
>In-frame_ENST00000333936_ENST00000374264_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(transcript)=2123nt_BP=1615nt
CCGCGCCCGCGCCCCCGCCGCCGCCATGGGCGTGCAGGGCTTCCAGGACTACATCGAGAAGCACTGCCCGAGCGCCGTGGTGCCGGTGGA
GCTGCAGAAGCTGGCCCGGGGCAGCCTGGTGGGCGGCGGGCGGCAGCGGCCCCCGCAGACCCCGCTGCGCCTGCTGGTGGACGCCGACAA
CTGCCTGCACCGCCTCTACGGCGGCTTCTACACCGACTGGGTCAGCGGCGGCCAGTGGAACCACATGCTTGGCTACCTGGCGGCGCTGGC
CAAGGCCTGCTTCGGCGGCAACATCGAGCTCTTCGTCTTCTTCAACGGCGCGCTCGAGAAGGCCCGGCTGCACGAGTGGGTCAAGCGGCA
GGGCAACGAGCGCCAGACGGCACAGCAGATCGTCAGCCATGTCCAGAACAAGGGCACCCCGCCGCCAAAGGTCTGGTTCCTGCCGCCCGT
CTGCATGGCCCACTGCATCCGCCTGGCGCTCATCCGCTTCCACGTCAAGGTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGG
TTTCTGCAGAGAGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGC
CCTAAAACTGAGCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCG
TTTTCCTATTTTTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACA
TCCACTAGCCTCACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAA
CATTCAGGACACCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAA
GAGAGCAATTGGATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAGCAGCCAGACCCGGTCCGTTTGGAAT
GCCTGGGATGGTGCCGCCGCATGTTCCTCCTCAGATGCTCAACATTCCGCAGACCTCTCTGCAAGCAAAGCCCGTGGCCCCACAGGTGCC
CAGCCCAGGGGGCGCCCCGGGCCAGGGTCCATACCCGTACAGCCTCTCTGAGCCAGCACCTCTCACTTTGGACACGAGCGGGAAGAATCT
GACGGAGCAGAACAGCTACAGCAACATTCCTCACGAAGGGAAGCACACGCCGCTGTATGAGCGGTCCTCGCCCATCAACCCGGCCCAGAG
CGGCAGCCCCAACCACGTGGATTCCGCCTACTTCCCTGGCTCTTCTACATCGTCATCTTCCGACAACGACGAGGGCAGCGGAGGGGCGAC
AAAGCCTTTCCAACTCTACTTGCAAAAAAACTTTGTGTTTCACAAAGAGAATTCCATCGTGCTCTGCTCCAGGATCCTGAGGCATGGCCA
TATCAGCGGGAACAAGATTGGCTGGGAGAAGACGGGAAGCCACTCAGAGCCTCAGGCACGAGGAGACCCAGGAGACCAAACAAAGATTCG
TCACTCATGCTGCTGCAGATGGCGGGTGTTGGACTGGGTTCCCTGGCTGTTGTGATCATTCTCACATTCCTCTCCTTCTCAGCGGTGTGA
TGGCAGATGGACACTGAGTGGGGAGGATGCACTGCTGCTGGGCAGGTGTTCTGGCAGCTTCTCAGGTGCCCGCACAGAGGCTCCGTGTGA
CTTCCGTCCAGGGAGCATGTGGGCCTGCAACTTTCTCCATTCCCAGCTGGGCCCCATTCCTGGATTTAAGATGGTGGCTATCCCTGAGGA
GTCACCATAAGGAGAAAACTCAGGAATTCTGAGTCTTCCCTGCTACAGGACCAGTTCTGTGCAATGAACTTGAGACTCCTGATGTACACT
GTGATATTGACCGAAGGCTACATACAGATCTGTGAATCTTGGCTGGGACTTCCTCTGAGTGATGCCTGAGGGTCAGCTCCTCTAGACATT

>In-frame_ENST00000333936_ENST00000374264_TCGA-DX-AATS-01A_FAM120A_chr9_96289524_+_SUSD1_chr9_114804240_length(amino acids)=549AA_start in transcript=25_stop in transcript=1674
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNI
ELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVR
AHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHV
PPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDS
AYFPGSSTSSSSDNDEGSGGATKPFQLYLQKNFVFHKENSIVLCSRILRHGHISGNKIGWEKTGSHSEPQARGDPGDQTKIRHSCCCRWR

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Fusion Gene PPI Analysis for FAM120A-SUSD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneFAM120Achr9:96289524chr9:114804240ENST00000277165+818339_405502.01119.0YES1%2C SRC and FYN
HgeneFAM120Achr9:96289524chr9:114804240ENST00000333936+919339_405530.01147.0YES1%2C SRC and FYN
HgeneFAM120Achr9:96289524chr9:114804240ENST00000340893+817339_405502.01073.0YES1%2C SRC and FYN
HgeneFAM120Achr9:96289524chr9:114804240ENST00000375389+89339_405502.0629.0YES1%2C SRC and FYN


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM120A-SUSD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM120A-SUSD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource