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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM135A-NACA (FusionGDB2 ID:28442)

Fusion Gene Summary for FAM135A-NACA

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM135A-NACA
Fusion gene ID: 28442
HgeneTgene
Gene symbol

FAM135A

NACA

Gene ID

57579

4666

Gene namefamily with sequence similarity 135 member Anascent polypeptide associated complex subunit alpha
SynonymsKIAA1411HSD48|NAC-alpha|NACA1|skNAC
Cytomap

6q13

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM135Anascent polypeptide-associated complex subunit alphaalpha-NAC, muscle-specific formnascent-polypeptide-associated complex alpha polypeptide
Modification date2020031320200313
UniProtAcc

Q9P2D6

Q9H009

Ensembl transtripts involved in fusion geneENST00000418814, ENST00000370479, 
ENST00000505769, ENST00000457062, 
ENST00000361499, ENST00000505868, 
ENST00000508844, 		ENST00000454682, 
ENST00000550952, ENST00000356769, 
ENST00000552540, ENST00000393891, 
ENST00000548563, ENST00000546392, 
ENST00000551793, 
Fusion gene scores* DoF score15 X 12 X 10=180015 X 16 X 4=960
# samples 1615
** MAII scorelog2(16/1800*10)=-3.49185309632968
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/960*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM135A [Title/Abstract] AND NACA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM135A(71263512)-NACA(57106653), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM135A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NACA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACN271038FAM135Achr6

71263512

+NACAchr12

57106653

-


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Fusion Gene ORF analysis for FAM135A-NACA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000418814ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000418814ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000418814ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000370479ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000370479ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505769ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000505769ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000457062ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000457062ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000361499ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000361499ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000505868ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000505868ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000454682FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000550952FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000356769FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000552540FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000393891FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000548563FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-3CDSENST00000508844ENST00000546392FAM135Achr6

71263512

+NACAchr12

57106653

-
intron-intronENST00000508844ENST00000551793FAM135Achr6

71263512

+NACAchr12

57106653

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FAM135A-NACA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM135A-NACA


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM135A

Q9P2D6

NACA

Q9H009

FUNCTION: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FAM135A-NACA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FAM135A-NACA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM135A-NACA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM135A-NACA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNACAC0004238Atrial Fibrillation2CTD_human
TgeneNACAC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneNACAC2585653Persistent atrial fibrillation2CTD_human
TgeneNACAC3468561familial atrial fibrillation2CTD_human