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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM49B-ASAP1 (FusionGDB2 ID:28977)

Fusion Gene Summary for FAM49B-ASAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM49B-ASAP1
Fusion gene ID: 28977
HgeneTgene
Gene symbol

FAM49B

ASAP1

Gene ID

51571

50807

Gene nameCYFIP related Rac1 interactor BArfGAP with SH3 domain, ankyrin repeat and PH domain 1
SynonymsBM-009|CYRI|CYRI-B|FAM49B|L1AMAP1|CENTB4|DDEF1|PAG2|PAP|ZG14P
Cytomap

8q24.21

8q24.21-q24.22

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM49BFAM49B/JPH1 fusionMTSS1/FAM49B fusionfamily with sequence similarity 49 member Barf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating proteinADP-ribosyl
Modification date2020031320200327
UniProtAcc.

Q9ULH1

Ensembl transtripts involved in fusion geneENST00000519824, ENST00000522746, 
ENST00000523509, ENST00000401979, 
ENST00000519110, ENST00000522250, 
ENST00000517654, ENST00000519540, 
ENST00000522941, ENST00000518879, 
ENST00000357668, ENST00000518721, 
ENST00000520625, 
Fusion gene scores* DoF score30 X 20 X 14=840013 X 14 X 8=1456
# samples 3716
** MAII scorelog2(37/8400*10)=-4.50479215203717
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1456*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM49B [Title/Abstract] AND ASAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM49B(130983189)-ASAP1(131104389), # samples:2
FAM49B(130983189)-ASAP1(131165051), # samples:2
ASAP1(131370263)-FAM49B(130983241), # samples:1
ASAP1(131040176)-FAM49B(131023713), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM49B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ASAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A06Z-01AFAM49Bchr8

130983189

-ASAP1chr8

131104389

-
ChimerDB4CESCTCGA-C5-A7X5-01AFAM49Bchr8

130983189

-ASAP1chr8

131165051

-
ChimerDB4CESCTCGA-C5-A7X5-01AFAM49Bchr8

130951854

-ASAP1chr8

131165051

-
ChimerDB4LUADTCGA-4B-A93VFAM49Bchr8

130915558

-ASAP1chr8

131124568

-
ChimerDB4STADTCGA-CG-5721-01AFAM49Bchr8

130915558

-ASAP1chr8

131249240

-
ChimerDB4BRCATCGA-A8-A06Z-01AFAM49Bchr8

130983189

-ASAP1chr8

131104389

-
ChimerDB4CESCTCGA-C5-A7X5-01AFAM49Bchr8

130983189

-ASAP1chr8

131165051

-


Top

Fusion Gene ORF analysis for FAM49B-ASAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000519824ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000519824ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-intronENST00000519824ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000522746ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000522746ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-intronENST00000522746ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000523509ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000523509ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-intronENST00000523509ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000401979ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000401979ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-intronENST00000401979ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000519110ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000519110ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-intronENST00000519110ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000522250ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000522250ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-intronENST00000522250ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000517654ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000517654ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-intronENST00000517654ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000519540ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000519540ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-intronENST00000519540ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000522941ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000522941ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-intronENST00000522941ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000518879ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-3CDSENST00000518879ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
5UTR-intronENST00000518879ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131104389

-
intron-3CDSENST00000519824ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-3CDSENST00000519824ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-intronENST00000519824ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-3CDSENST00000522746ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-3CDSENST00000522746ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-intronENST00000522746ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000523509ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000523509ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-intronENST00000523509ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000401979ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000401979ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-intronENST00000401979ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000519110ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000519110ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-intronENST00000519110ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-3CDSENST00000522250ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-3CDSENST00000522250ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-intronENST00000522250ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000517654ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000517654ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-intronENST00000517654ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-3CDSENST00000519540ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-3CDSENST00000519540ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-intronENST00000519540ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-3CDSENST00000522941ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-3CDSENST00000522941ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
intron-intronENST00000522941ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000518879ENST00000357668FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000518879ENST00000518721FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-intronENST00000518879ENST00000520625FAM49Bchr8

130983189

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000519824ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000519824ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-intronENST00000519824ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000522746ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000522746ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-intronENST00000522746ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000523509ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000523509ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-intronENST00000523509ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000401979ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000401979ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-intronENST00000401979ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000519110ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000519110ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-intronENST00000519110ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000522250ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000522250ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-intronENST00000522250ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000517654ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000517654ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-intronENST00000517654ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000519540ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000519540ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-intronENST00000519540ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000522941ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000522941ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-intronENST00000522941ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000518879ENST00000357668FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-3CDSENST00000518879ENST00000518721FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
intron-intronENST00000518879ENST00000520625FAM49Bchr8

130951854

-ASAP1chr8

131165051

-
5UTR-3CDSENST00000519824ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000519824ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-intronENST00000519824ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000522746ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000522746ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-intronENST00000522746ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000523509ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000523509ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-intronENST00000523509ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000401979ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000401979ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-intronENST00000401979ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000519110ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000519110ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-intronENST00000519110ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
intron-3CDSENST00000522250ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
intron-3CDSENST00000522250ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
intron-intronENST00000522250ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000517654ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000517654ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-intronENST00000517654ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000519540ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000519540ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-intronENST00000519540ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000522941ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000522941ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-intronENST00000522941ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000518879ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000518879ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-intronENST00000518879ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131124568

-
5UTR-3CDSENST00000519824ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000519824ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-intronENST00000519824ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000522746ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000522746ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-intronENST00000522746ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000523509ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000523509ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-intronENST00000523509ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000401979ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000401979ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-intronENST00000401979ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000519110ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000519110ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-intronENST00000519110ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
intron-3CDSENST00000522250ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
intron-3CDSENST00000522250ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
intron-intronENST00000522250ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000517654ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000517654ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-intronENST00000517654ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000519540ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000519540ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-intronENST00000519540ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000522941ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000522941ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-intronENST00000522941ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000518879ENST00000357668FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-3CDSENST00000518879ENST00000518721FAM49Bchr8

130915558

-ASAP1chr8

131249240

-
5UTR-intronENST00000518879ENST00000520625FAM49Bchr8

130915558

-ASAP1chr8

131249240

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FAM49B-ASAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FAM49B-ASAP1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASAP1

Q9ULH1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. {ECO:0000250, ECO:0000269|PubMed:20393563}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FAM49B-ASAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FAM49B-ASAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM49B-ASAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM49B-ASAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneASAP1C0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneASAP1C0005695Bladder Neoplasm1CTD_human
TgeneASAP1C0041327Tuberculosis, Pulmonary1CTD_human
TgeneASAP1C0087031Juvenile-Onset Still Disease1CTD_human
TgeneASAP1C3495559Juvenile arthritis1CTD_human
TgeneASAP1C3714758Juvenile psoriatic arthritis1CTD_human
TgeneASAP1C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneASAP1C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human