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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AGAP1-WDR11 (FusionGDB2 ID:2916)

Fusion Gene Summary for AGAP1-WDR11

check button Fusion gene summary
Fusion gene informationFusion gene name: AGAP1-WDR11
Fusion gene ID: 2916
HgeneTgene
Gene symbol

AGAP1

WDR11

Gene ID

116987

55717

Gene nameArfGAP with GTPase domain, ankyrin repeat and PH domain 1WD repeat domain 11
SynonymsAGAP-1|CENTG2|GGAP1|cnt-g2BRWD2|DR11|HH14|SRI1|WDR15
Cytomap

2q37.2

10q26.12

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2WD repeat-containing protein 11WD repeat domain 15WD repeat-containing protein 15bromodomain and WD repeat-containing protein 2sensitization to ricin complex subunit 1
Modification date2020031320200313
UniProtAcc

Q9UPQ3

.
Ensembl transtripts involved in fusion geneENST00000336665, ENST00000304032, 
ENST00000409538, ENST00000428334, 
ENST00000409457, 		ENST00000263461, 
ENST00000604509, 
Fusion gene scores* DoF score49 X 18 X 17=149943 X 3 X 1=9
# samples 484
** MAII scorelog2(48/14994*10)=-4.96520709119934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AGAP1 [Title/Abstract] AND WDR11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGAP1(236403493)-WDR11(122659541), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWDR11

GO:0006886

intracellular protein transport

29426865

TgeneWDR11

GO:0099041

vesicle tethering to Golgi

29426865


check buttonFusion gene breakpoints across AGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WDR11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08O-01AAGAP1chr2

236403493

+WDR11chr10

122659541

+
ChimerDB4BRCATCGA-A8-A08OAGAP1chr2

236403493

+WDR11chr10

122659540

+
ChimerDB4BRCATCGA-A8-A08O-01AAGAP1chr2

236403493

+WDR11chr10

122659541

+
ChimerDB4BRCATCGA-A8-A08O-01AAGAP1chr2

236403493

-WDR11chr10

122659541

+


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Fusion Gene ORF analysis for AGAP1-WDR11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000336665ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
5CDS-3UTRENST00000336665ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+
In-frameENST00000304032ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
5CDS-3UTRENST00000304032ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+
intron-3CDSENST00000409538ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
intron-3UTRENST00000409538ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+
intron-3CDSENST00000428334ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
intron-3UTRENST00000428334ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+
In-frameENST00000409457ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
5CDS-3UTRENST00000409457ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+
In-frameENST00000336665ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659540

+
5CDS-3UTRENST00000336665ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659540

+
In-frameENST00000304032ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659540

+
5CDS-3UTRENST00000304032ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659540

+
intron-3CDSENST00000409538ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659540

+
intron-3UTRENST00000409538ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659540

+
intron-3CDSENST00000428334ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659540

+
intron-3UTRENST00000428334ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659540

+
In-frameENST00000409457ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659540

+
5CDS-3UTRENST00000409457ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659540

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336665AGAP1chr2236403493+ENST00000263461WDR11chr10122659541+27147434211902493
ENST00000304032AGAP1chr2236403493+ENST00000263461WDR11chr10122659541+27147434211902493
ENST00000409457AGAP1chr2236403493+ENST00000263461WDR11chr10122659541+27327614391920493
ENST00000336665AGAP1chr2236403493+ENST00000263461WDR11chr10122659540+27147434211902493
ENST00000304032AGAP1chr2236403493+ENST00000263461WDR11chr10122659540+27147434211902493
ENST00000409457AGAP1chr2236403493+ENST00000263461WDR11chr10122659540+27327614391920493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336665ENST00000263461AGAP1chr2236403493+WDR11chr10122659541+0.0015682440.99843174
ENST00000304032ENST00000263461AGAP1chr2236403493+WDR11chr10122659541+0.0015682440.99843174
ENST00000409457ENST00000263461AGAP1chr2236403493+WDR11chr10122659541+0.001635210.99836475
ENST00000336665ENST00000263461AGAP1chr2236403493+WDR11chr10122659540+0.0015682440.99843174
ENST00000304032ENST00000263461AGAP1chr2236403493+WDR11chr10122659540+0.0015682440.99843174
ENST00000409457ENST00000263461AGAP1chr2236403493+WDR11chr10122659540+0.001635210.99836475

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Fusion Genomic Features for AGAP1-WDR11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AGAP1chr2236403493+WDR11chr10122659540+2.00E-060.999998
AGAP1chr2236403493+WDR11chr10122659540+2.00E-060.999998
AGAP1chr2236403493+WDR11chr10122659540+2.00E-060.999998
AGAP1chr2236403493+WDR11chr10122659540+2.00E-060.999998

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AGAP1-WDR11


check button Go to

FGviewer for the breakpoints of chr2:236403493-chr10:122659541

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGAP1

Q9UPQ3

.
FUNCTION: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR11chr2:236403493chr10:122659540ENST000002634611829893_940838.33333333333341225.0RepeatNote=WD 9
TgeneWDR11chr2:236403493chr10:122659541ENST000002634611829893_940838.33333333333341225.0RepeatNote=WD 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP1chr2:236403493chr10:122659540ENST00000304032+118346_58854.333333333333336858.0DomainPH
HgeneAGAP1chr2:236403493chr10:122659540ENST00000304032+118609_72954.333333333333336858.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000336665+117346_58854.333333333333336805.0DomainPH
HgeneAGAP1chr2:236403493chr10:122659540ENST00000336665+117609_72954.333333333333336805.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000409457+110346_58854.333333333333336406.0DomainPH
HgeneAGAP1chr2:236403493chr10:122659540ENST00000409457+110609_72954.333333333333336406.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118346_58854.333333333333336858.0DomainPH
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118609_72954.333333333333336858.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117346_58854.333333333333336805.0DomainPH
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117609_72954.333333333333336805.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110346_58854.333333333333336406.0DomainPH
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110609_72954.333333333333336406.0DomainArf-GAP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000304032+118122_12654.333333333333336858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000304032+118178_18154.333333333333336858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000304032+11878_8554.333333333333336858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000336665+117122_12654.333333333333336805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000336665+117178_18154.333333333333336805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000336665+11778_8554.333333333333336805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000409457+110122_12654.333333333333336406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000409457+110178_18154.333333333333336406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000409457+11078_8554.333333333333336406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118122_12654.333333333333336858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118178_18154.333333333333336858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+11878_8554.333333333333336858.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117122_12654.333333333333336805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117178_18154.333333333333336805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+11778_8554.333333333333336805.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110122_12654.333333333333336406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110178_18154.333333333333336406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+11078_8554.333333333333336406.0Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659540ENST00000304032+11866_27654.333333333333336858.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr10:122659540ENST00000336665+11766_27654.333333333333336805.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr10:122659540ENST00000409457+11066_27654.333333333333336406.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+11866_27654.333333333333336858.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+11766_27654.333333333333336805.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+11066_27654.333333333333336406.0RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr10:122659540ENST00000304032+118768_79754.333333333333336858.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr10:122659540ENST00000304032+118801_83054.333333333333336858.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr10:122659540ENST00000336665+117768_79754.333333333333336805.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr10:122659540ENST00000336665+117801_83054.333333333333336805.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr10:122659540ENST00000409457+110768_79754.333333333333336406.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr10:122659540ENST00000409457+110801_83054.333333333333336406.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118768_79754.333333333333336858.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118801_83054.333333333333336858.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117768_79754.333333333333336805.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117801_83054.333333333333336805.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110768_79754.333333333333336406.0RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110801_83054.333333333333336406.0RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr10:122659540ENST00000304032+118624_64754.333333333333336858.0Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr10:122659540ENST00000336665+117624_64754.333333333333336805.0Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr10:122659540ENST00000409457+110624_64754.333333333333336406.0Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118624_64754.333333333333336858.0Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117624_64754.333333333333336805.0Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110624_64754.333333333333336406.0Zinc fingerC4-type
TgeneWDR11chr2:236403493chr10:122659540ENST000002634611829111_154838.33333333333341225.0RepeatNote=WD 2
TgeneWDR11chr2:236403493chr10:122659540ENST000002634611829354_393838.33333333333341225.0RepeatNote=WD 3
TgeneWDR11chr2:236403493chr10:122659540ENST000002634611829471_510838.33333333333341225.0RepeatNote=WD 4
TgeneWDR11chr2:236403493chr10:122659540ENST000002634611829566_605838.33333333333341225.0RepeatNote=WD 5
TgeneWDR11chr2:236403493chr10:122659540ENST00000263461182959_108838.33333333333341225.0RepeatNote=WD 1
TgeneWDR11chr2:236403493chr10:122659540ENST000002634611829708_745838.33333333333341225.0RepeatNote=WD 6
TgeneWDR11chr2:236403493chr10:122659540ENST000002634611829747_787838.33333333333341225.0RepeatNote=WD 7
TgeneWDR11chr2:236403493chr10:122659540ENST000002634611829793_831838.33333333333341225.0RepeatNote=WD 8
TgeneWDR11chr2:236403493chr10:122659541ENST000002634611829111_154838.33333333333341225.0RepeatNote=WD 2
TgeneWDR11chr2:236403493chr10:122659541ENST000002634611829354_393838.33333333333341225.0RepeatNote=WD 3
TgeneWDR11chr2:236403493chr10:122659541ENST000002634611829471_510838.33333333333341225.0RepeatNote=WD 4
TgeneWDR11chr2:236403493chr10:122659541ENST000002634611829566_605838.33333333333341225.0RepeatNote=WD 5
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461182959_108838.33333333333341225.0RepeatNote=WD 1
TgeneWDR11chr2:236403493chr10:122659541ENST000002634611829708_745838.33333333333341225.0RepeatNote=WD 6
TgeneWDR11chr2:236403493chr10:122659541ENST000002634611829747_787838.33333333333341225.0RepeatNote=WD 7
TgeneWDR11chr2:236403493chr10:122659541ENST000002634611829793_831838.33333333333341225.0RepeatNote=WD 8


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Fusion Gene Sequence for AGAP1-WDR11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000336665_ENST00000263461_TCGA-A8-A08O-01A_AGAP1_chr2_236403493_+_WDR11_chr10_122659541_length(transcript)=2714nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACA
CCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTT
GAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGG
TGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAA
AGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCT
AGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGA
CAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCAC
CTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTG
CCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAA
TCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCT
CCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCT
CAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGG
TTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGAGTCCCCCAAGGAAGAACC
CATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGGCTGTGGCCACCGTCACAG
TCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAGCACATAAGCATCTATGTT
GAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATATTTTATACTTTGGGAGAGA
GCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCATTGATTAAATGTAAAGAT
TATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATACAGTCTTTCAAGAGAGAT
ACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTGAAAACACAGAACCGTTAA
TTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTATGTTTAGTCCGATAGGTGA
GGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTTGTACTTTAATGTTCTCTC
TGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTACAAACATGATAAATAAATT

>In-frame_ENST00000336665_ENST00000263461_TCGA-A8-A08O-01A_AGAP1_chr2_236403493_+_WDR11_chr10_122659541_length(amino acids)=493AA_start in transcript=421_stop in transcript=1902
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQ
RCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCT
DQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNR
AAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYA

--------------------------------------------------------------
>In-frame_ENST00000304032_ENST00000263461_TCGA-A8-A08O-01A_AGAP1_chr2_236403493_+_WDR11_chr10_122659541_length(transcript)=2714nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACA
CCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTT
GAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGG
TGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAA
AGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCT
AGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGA
CAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCAC
CTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTG
CCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAA
TCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCT
CCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCT
CAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGG
TTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGAGTCCCCCAAGGAAGAACC
CATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGGCTGTGGCCACCGTCACAG
TCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAGCACATAAGCATCTATGTT
GAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATATTTTATACTTTGGGAGAGA
GCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCATTGATTAAATGTAAAGAT
TATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATACAGTCTTTCAAGAGAGAT
ACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTGAAAACACAGAACCGTTAA
TTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTATGTTTAGTCCGATAGGTGA
GGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTTGTACTTTAATGTTCTCTC
TGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTACAAACATGATAAATAAATT

>In-frame_ENST00000304032_ENST00000263461_TCGA-A8-A08O-01A_AGAP1_chr2_236403493_+_WDR11_chr10_122659541_length(amino acids)=493AA_start in transcript=421_stop in transcript=1902
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQ
RCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCT
DQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNR
AAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYA

--------------------------------------------------------------
>In-frame_ENST00000409457_ENST00000263461_TCGA-A8-A08O-01A_AGAP1_chr2_236403493_+_WDR11_chr10_122659541_length(transcript)=2732nt_BP=761nt
GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC
CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC
CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC
TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC
TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC
GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC
CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC
TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT
GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTT
GAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAA
TCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCT
TGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGC
CAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTA
CTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACT
GCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTG
TTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGA
GGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCT
GGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATC
AAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTT
ATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCG
GAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGA
GTCCCCCAAGGAAGAACCCATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGG
CTGTGGCCACCGTCACAGTCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAG
CACATAAGCATCTATGTTGAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATAT
TTTATACTTTGGGAGAGAGCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCA
TTGATTAAATGTAAAGATTATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATA
CAGTCTTTCAAGAGAGATACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTG
AAAACACAGAACCGTTAATTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTAT
GTTTAGTCCGATAGGTGAGGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTT
GTACTTTAATGTTCTCTCTGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTAC

>In-frame_ENST00000409457_ENST00000263461_TCGA-A8-A08O-01A_AGAP1_chr2_236403493_+_WDR11_chr10_122659541_length(amino acids)=493AA_start in transcript=439_stop in transcript=1920
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQ
RCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCT
DQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNR
AAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYA

--------------------------------------------------------------
>In-frame_ENST00000336665_ENST00000263461_TCGA-A8-A08O_AGAP1_chr2_236403493_+_WDR11_chr10_122659540_length(transcript)=2714nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACA
CCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTT
GAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGG
TGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAA
AGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCT
AGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGA
CAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCAC
CTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTG
CCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAA
TCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCT
CCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCT
CAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGG
TTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGAGTCCCCCAAGGAAGAACC
CATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGGCTGTGGCCACCGTCACAG
TCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAGCACATAAGCATCTATGTT
GAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATATTTTATACTTTGGGAGAGA
GCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCATTGATTAAATGTAAAGAT
TATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATACAGTCTTTCAAGAGAGAT
ACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTGAAAACACAGAACCGTTAA
TTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTATGTTTAGTCCGATAGGTGA
GGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTTGTACTTTAATGTTCTCTC
TGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTACAAACATGATAAATAAATT

>In-frame_ENST00000336665_ENST00000263461_TCGA-A8-A08O_AGAP1_chr2_236403493_+_WDR11_chr10_122659540_length(amino acids)=493AA_start in transcript=421_stop in transcript=1902
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQ
RCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCT
DQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNR
AAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYA

--------------------------------------------------------------
>In-frame_ENST00000304032_ENST00000263461_TCGA-A8-A08O_AGAP1_chr2_236403493_+_WDR11_chr10_122659540_length(transcript)=2714nt_BP=743nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACA
CCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTT
GAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGG
TGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAA
AGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCT
AGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGA
CAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCAC
CTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTG
CCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAA
TCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCT
CCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCT
CAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGG
TTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGAGTCCCCCAAGGAAGAACC
CATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGGCTGTGGCCACCGTCACAG
TCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAGCACATAAGCATCTATGTT
GAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATATTTTATACTTTGGGAGAGA
GCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCATTGATTAAATGTAAAGAT
TATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATACAGTCTTTCAAGAGAGAT
ACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTGAAAACACAGAACCGTTAA
TTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTATGTTTAGTCCGATAGGTGA
GGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTTGTACTTTAATGTTCTCTC
TGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTACAAACATGATAAATAAATT

>In-frame_ENST00000304032_ENST00000263461_TCGA-A8-A08O_AGAP1_chr2_236403493_+_WDR11_chr10_122659540_length(amino acids)=493AA_start in transcript=421_stop in transcript=1902
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQ
RCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCT
DQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNR
AAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYA

--------------------------------------------------------------
>In-frame_ENST00000409457_ENST00000263461_TCGA-A8-A08O_AGAP1_chr2_236403493_+_WDR11_chr10_122659540_length(transcript)=2732nt_BP=761nt
GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC
CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC
CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC
TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC
TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC
GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC
CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC
TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT
GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTT
GAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAA
TCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCT
TGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGC
CAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTA
CTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACT
GCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTG
TTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGA
GGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCT
GGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATC
AAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTT
ATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCG
GAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGA
GTCCCCCAAGGAAGAACCCATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGG
CTGTGGCCACCGTCACAGTCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAG
CACATAAGCATCTATGTTGAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATAT
TTTATACTTTGGGAGAGAGCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCA
TTGATTAAATGTAAAGATTATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATA
CAGTCTTTCAAGAGAGATACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTG
AAAACACAGAACCGTTAATTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTAT
GTTTAGTCCGATAGGTGAGGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTT
GTACTTTAATGTTCTCTCTGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTAC

>In-frame_ENST00000409457_ENST00000263461_TCGA-A8-A08O_AGAP1_chr2_236403493_+_WDR11_chr10_122659540_length(amino acids)=493AA_start in transcript=439_stop in transcript=1920
MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV
EEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQ
RCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCT
DQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNR
AAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYA

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Fusion Gene PPI Analysis for AGAP1-WDR11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AGAP1-WDR11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AGAP1-WDR11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGAP1C0004352Autistic Disorder1CTD_human
TgeneWDR11C3540450HYPOGONADOTROPIC HYPOGONADISM 14 WITH OR WITHOUT ANOSMIA3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneWDR11C0162809Kallmann Syndrome2GENOMICS_ENGLAND;ORPHANET
TgeneWDR11C0013146Drug abuse1CTD_human
TgeneWDR11C0013170Drug habituation1CTD_human
TgeneWDR11C0013222Drug Use Disorders1CTD_human
TgeneWDR11C0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneWDR11C0036341Schizophrenia1CTD_human
TgeneWDR11C0038580Substance Dependence1CTD_human
TgeneWDR11C0038586Substance Use Disorders1CTD_human
TgeneWDR11C0236969Substance-Related Disorders1CTD_human
TgeneWDR11C0740858Substance abuse problem1CTD_human
TgeneWDR11C1510472Drug Dependence1CTD_human
TgeneWDR11C4053775Pituitary stalk interruption syndrome1ORPHANET
TgeneWDR11C4316881Prescription Drug Abuse1CTD_human