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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FARP1-NME1-NME2 (FusionGDB2 ID:29296)

Fusion Gene Summary for FARP1-NME1-NME2

check button Fusion gene summary
Fusion gene informationFusion gene name: FARP1-NME1-NME2
Fusion gene ID: 29296
HgeneTgene
Gene symbol

FARP1

NME1-NME2

Gene ID

10160

654364

Gene nameFERM, ARH/RhoGEF and pleckstrin domain protein 1NME1-NME2 readthrough
SynonymsCDEP|FARP1-IT1|PLEKHC2|PPP1R75NM23-LV|NMELV
Cytomap

13q32.2

17q21.33

Type of geneprotein-codingprotein-coding
DescriptionFERM, ARHGEF and pleckstrin domain-containing protein 1FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)FERM, RhoGEF and pleckstrin domain-containing protein 1PH domain-containing family C member 2chondrocyte-derived ezrin-liNME1-NME2 proteinNME1-NME2 readthrough transcript
Modification date2020031320200313
UniProtAcc

Q9Y4F1

.
Ensembl transtripts involved in fusion geneENST00000595437, ENST00000376586, 
ENST00000319562, ENST00000376581, 
ENST00000593990, 		ENST00000393198, 
ENST00000608447, ENST00000514264, 
ENST00000393185, ENST00000513177, 
ENST00000512737, ENST00000503064, 
ENST00000393183, ENST00000393190, 
Fusion gene scores* DoF score19 X 13 X 10=24706 X 7 X 3=126
# samples 227
** MAII scorelog2(22/2470*10)=-3.48893561294738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FARP1 [Title/Abstract] AND NME1-NME2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFARP1(98865667)-NME1-NME2(49237341), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFARP1

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across FARP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NME1-NME2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DB-5275-01AFARP1chr13

98865667

-NME1-NME2chr17

49237341

+


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Fusion Gene ORF analysis for FARP1-NME1-NME2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000595437ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000595437ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000376586ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000376586ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000319562ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000319562ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000376581ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000376581ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-3CDSENST00000593990ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-3CDSENST00000593990ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000595437FARP1chr1398865667-ENST00000393198NME1-NME2chr1749237341+12274102391087282
ENST00000595437FARP1chr1398865667-ENST00000608447NME1-NME2chr1749237341+12264102391087282
ENST00000376586FARP1chr1398865667-ENST00000393198NME1-NME2chr1749237341+13245073361184282
ENST00000376586FARP1chr1398865667-ENST00000608447NME1-NME2chr1749237341+13235073361184282
ENST00000319562FARP1chr1398865667-ENST00000393198NME1-NME2chr1749237341+12534362651113282
ENST00000319562FARP1chr1398865667-ENST00000608447NME1-NME2chr1749237341+12524362651113282
ENST00000376581FARP1chr1398865667-ENST00000393198NME1-NME2chr1749237341+102420736884282
ENST00000376581FARP1chr1398865667-ENST00000608447NME1-NME2chr1749237341+102320736884282

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000595437ENST00000393198FARP1chr1398865667-NME1-NME2chr1749237341+0.0024866830.9975133
ENST00000595437ENST00000608447FARP1chr1398865667-NME1-NME2chr1749237341+0.0025401110.99745995
ENST00000376586ENST00000393198FARP1chr1398865667-NME1-NME2chr1749237341+0.0019188310.9980812
ENST00000376586ENST00000608447FARP1chr1398865667-NME1-NME2chr1749237341+0.0019446880.99805534
ENST00000319562ENST00000393198FARP1chr1398865667-NME1-NME2chr1749237341+0.0020964220.9979036
ENST00000319562ENST00000608447FARP1chr1398865667-NME1-NME2chr1749237341+0.0021253240.99787474
ENST00000376581ENST00000393198FARP1chr1398865667-NME1-NME2chr1749237341+0.0012570870.998743
ENST00000376581ENST00000608447FARP1chr1398865667-NME1-NME2chr1749237341+0.0012713840.9987286

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Fusion Genomic Features for FARP1-NME1-NME2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FARP1-NME1-NME2


check button Go to

FGviewer for the breakpoints of chr13:98865667-chr17:49237341

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FARP1

Q9Y4F1

.
FUNCTION: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-227449_45357.01046.0Compositional biasNote=Poly-Glu
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-23449_45357.0130.0Compositional biasNote=Poly-Glu
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-22740_32057.01046.0DomainFERM
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-227540_73057.01046.0DomainDH
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-227759_85657.01046.0DomainPH 1
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-227932_102957.01046.0DomainPH 2
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-2340_32057.0130.0DomainFERM
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-23540_73057.0130.0DomainDH
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-23759_85657.0130.0DomainPH 1
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-23932_102957.0130.0DomainPH 2


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Fusion Gene Sequence for FARP1-NME1-NME2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000595437_ENST00000393198_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(transcript)=1227nt_BP=410nt
AAGTCCCGCGCAGCCCGGGGTGGTGCCGGAAGCCCGTGCCTGTGGCTCCGGGGGAGGGGAGGGCTCGGTGGGTCCCTGAAGACTGTCCTC
CCCGCGCGACGTCGCAGGCGAAGCAGCCCCAGGCAGGACCTCAAAAAGCGACCTGCAGAGTCCGAGCCCCTGACCGCCCGCCTGCCGCTC
CCGGCTTCGCCGTGCACACGTCTCCCGCTCTCCCCGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCGACCCCAG
GATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAACTCGTGT
CCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGA
AGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGA
CGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCA
TGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGA
AGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTCT
TCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGAGTGATGC
TTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGTG
ATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGACTGGGTCT
ATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTTAGAGGCA

>In-frame_ENST00000595437_ENST00000393198_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(amino acids)=282AA_start in transcript=239_stop in transcript=1087
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>In-frame_ENST00000595437_ENST00000608447_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(transcript)=1226nt_BP=410nt
AAGTCCCGCGCAGCCCGGGGTGGTGCCGGAAGCCCGTGCCTGTGGCTCCGGGGGAGGGGAGGGCTCGGTGGGTCCCTGAAGACTGTCCTC
CCCGCGCGACGTCGCAGGCGAAGCAGCCCCAGGCAGGACCTCAAAAAGCGACCTGCAGAGTCCGAGCCCCTGACCGCCCGCCTGCCGCTC
CCGGCTTCGCCGTGCACACGTCTCCCGCTCTCCCCGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCGACCCCAG
GATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAACTCGTGT
CCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGA
AGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGA
CGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCA
TGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGA
AGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTCT
TCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGAGTGATGC
TTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGTG
ATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGACTGGGTCT
ATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTTAGAGGCA

>In-frame_ENST00000595437_ENST00000608447_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(amino acids)=282AA_start in transcript=239_stop in transcript=1087
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>In-frame_ENST00000376586_ENST00000393198_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(transcript)=1324nt_BP=507nt
GCGGCCGCTGCCCGCTTTGCGCCGCTCCTCCCTGCGCGAGTAGCGCTGGCCCCGGCGTCGAGGCGGCCATGGCGACCCGGAGCCCGCTCC
CCACCCACCCCGCCTGCTCCGCCCTCCCCTCCGCCCCGCGCCACCTTTGATGGCTCGGACCTCAGCCGGCCACCGCCAGCCCTGCTCGCG
CGCCCGCGCCGCCGCCGCCCGCGGGTATTAATAGCCGGCGCCGCCGCGCCCTCGGCCGCCGGGGGCTTGGGAGCCGCCGATCCCGGAGCC
CGAGCCGGGAGAGGGAGCCGCCGCAGCCGCCGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCG
ACCCCAGGATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAA
CTCGTGTCCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTT
GACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTG
GTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGC
AGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTC
GAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGA
CCATTCTTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGA
GTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCAT
GGCAGTGATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGAC
TGGGTCTATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTT

>In-frame_ENST00000376586_ENST00000393198_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(amino acids)=282AA_start in transcript=336_stop in transcript=1184
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>In-frame_ENST00000376586_ENST00000608447_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(transcript)=1323nt_BP=507nt
GCGGCCGCTGCCCGCTTTGCGCCGCTCCTCCCTGCGCGAGTAGCGCTGGCCCCGGCGTCGAGGCGGCCATGGCGACCCGGAGCCCGCTCC
CCACCCACCCCGCCTGCTCCGCCCTCCCCTCCGCCCCGCGCCACCTTTGATGGCTCGGACCTCAGCCGGCCACCGCCAGCCCTGCTCGCG
CGCCCGCGCCGCCGCCGCCCGCGGGTATTAATAGCCGGCGCCGCCGCGCCCTCGGCCGCCGGGGGCTTGGGAGCCGCCGATCCCGGAGCC
CGAGCCGGGAGAGGGAGCCGCCGCAGCCGCCGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCG
ACCCCAGGATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAA
CTCGTGTCCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTT
GACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTG
GTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGC
AGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTC
GAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGA
CCATTCTTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGA
GTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCAT
GGCAGTGATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGAC
TGGGTCTATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTT

>In-frame_ENST00000376586_ENST00000608447_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(amino acids)=282AA_start in transcript=336_stop in transcript=1184
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>In-frame_ENST00000319562_ENST00000393198_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(transcript)=1253nt_BP=436nt
GCGACCCGGAGCCCGCTCCCCACCCACCCCGCCTGCTCCGCCCTCCCCTCCGCCCCGCGCCACCTTTGATGGCTCGGACCTCAGCCGGCC
ACCGCCAGCCCTGCTCGCGCGCCCGCGCCGCCGCCGCCCGCGGGTATTAATAGCCGGCGCCGCCGCGCCCTCGGCCGCCGGGGGCTTGGG
AGCCGCCGATCCCGGAGCCCGAGCCGGGAGAGGGAGCCGCCGCAGCCGCCGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGG
AGAAATAGAGCAGAGGCCGACCCCAGGATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCC
CCCAACACCTTCAGGAAAACTCGTGTCCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCT
TCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGT
CTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGA
CTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGG
CGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTA
CATTGACCTGAAAGACCGACCATTCTTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAA
CGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGT
TGGCAGGAACATCATTCATGGCAGTGATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTA
CAAGTCTTGTGCTCATGACTGGGTCTATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAG

>In-frame_ENST00000319562_ENST00000393198_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(amino acids)=282AA_start in transcript=265_stop in transcript=1113
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>In-frame_ENST00000319562_ENST00000608447_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(transcript)=1252nt_BP=436nt
GCGACCCGGAGCCCGCTCCCCACCCACCCCGCCTGCTCCGCCCTCCCCTCCGCCCCGCGCCACCTTTGATGGCTCGGACCTCAGCCGGCC
ACCGCCAGCCCTGCTCGCGCGCCCGCGCCGCCGCCGCCCGCGGGTATTAATAGCCGGCGCCGCCGCGCCCTCGGCCGCCGGGGGCTTGGG
AGCCGCCGATCCCGGAGCCCGAGCCGGGAGAGGGAGCCGCCGCAGCCGCCGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGG
AGAAATAGAGCAGAGGCCGACCCCAGGATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCC
CCCAACACCTTCAGGAAAACTCGTGTCCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCT
TCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGT
CTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGA
CTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGG
CGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTA
CATTGACCTGAAAGACCGACCATTCTTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAA
CGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGT
TGGCAGGAACATCATTCATGGCAGTGATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTA
CAAGTCTTGTGCTCATGACTGGGTCTATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAG

>In-frame_ENST00000319562_ENST00000608447_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(amino acids)=282AA_start in transcript=265_stop in transcript=1113
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>In-frame_ENST00000376581_ENST00000393198_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(transcript)=1024nt_BP=207nt
CGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCGACCCCAGGATCACGACTGGGGGCCCCGGAA
AATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAACTCGTGTCCATCAAAATCCAGATGCTGGAT
GACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGC
CTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAG
ACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTC
ATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATG
AAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTCTTCCCTGGGCTGGTGAAGTACATG
AACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGAT
TCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGTGATTCAGTAAAAAGTGCTGAAAAA
GAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGACTGGGTCTATGAATAAGAGGTGGACACAACA
GCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTTAGAGGCAACAGGATTGATCATTCTTTTATA

>In-frame_ENST00000376581_ENST00000393198_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(amino acids)=282AA_start in transcript=36_stop in transcript=884
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>In-frame_ENST00000376581_ENST00000608447_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(transcript)=1023nt_BP=207nt
CGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCGACCCCAGGATCACGACTGGGGGCCCCGGAA
AATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAACTCGTGTCCATCAAAATCCAGATGCTGGAT
GACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGC
CTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAG
ACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTC
ATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATG
AAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTCTTCCCTGGGCTGGTGAAGTACATG
AACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGAT
TCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGTGATTCAGTAAAAAGTGCTGAAAAA
GAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGACTGGGTCTATGAATAAGAGGTGGACACAACA
GCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTTAGAGGCAACAGGATTGATCATTCTTTTATA

>In-frame_ENST00000376581_ENST00000608447_TCGA-DB-5275-01A_FARP1_chr13_98865667_-_NME1-NME2_chr17_49237341_length(amino acids)=282AA_start in transcript=36_stop in transcript=884
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FARP1-NME1-NME2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNME1-NME2chr13:98865667chr17:49237341ENST00000393198181_6642.0268.0AKAP13


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FARP1-NME1-NME2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FARP1-NME1-NME2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFARP1C0013146Drug abuse1CTD_human
HgeneFARP1C0013170Drug habituation1CTD_human
HgeneFARP1C0013222Drug Use Disorders1CTD_human
HgeneFARP1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneFARP1C0038580Substance Dependence1CTD_human
HgeneFARP1C0038586Substance Use Disorders1CTD_human
HgeneFARP1C0236969Substance-Related Disorders1CTD_human
HgeneFARP1C0740858Substance abuse problem1CTD_human
HgeneFARP1C1510472Drug Dependence1CTD_human
HgeneFARP1C4316881Prescription Drug Abuse1CTD_human