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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAT1-APP (FusionGDB2 ID:29366)

Fusion Gene Summary for FAT1-APP

check button Fusion gene summary
Fusion gene informationFusion gene name: FAT1-APP
Fusion gene ID: 29366
HgeneTgene
Gene symbol

FAT1

APP

Gene ID

2195

351

Gene nameFAT atypical cadherin 1amyloid beta precursor protein
SynonymsCDHF7|CDHR8|FAT|ME5|hFat1AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4
Cytomap

4q35.2

21q21.3

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homologamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei
Modification date2020031320200329
UniProtAcc

Q14517

Q8NEU8

Ensembl transtripts involved in fusion geneENST00000441802, ENST00000512347, 
ENST00000346798, ENST00000354192, 
ENST00000348990, ENST00000357903, 
ENST00000358918, ENST00000359726, 
ENST00000448388, ENST00000440126, 
ENST00000439274, ENST00000474136, 
Fusion gene scores* DoF score16 X 17 X 8=217625 X 18 X 10=4500
# samples 2027
** MAII scorelog2(20/2176*10)=-3.44360665147561
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4500*10)=-4.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAT1 [Title/Abstract] AND APP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAT1(187627717)-APP(27372497), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

TgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

TgeneAPP

GO:1905606

regulation of presynapse assembly

19726636


check buttonFusion gene breakpoints across FAT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across APP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-PC-A5DN-01AFAT1chr4

187627717

-APPchr21

27372497

-


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Fusion Gene ORF analysis for FAT1-APP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000441802ENST00000346798FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000354192FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000348990FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000357903FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000358918FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000359726FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000448388FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000440126FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000439274FAT1chr4

187627717

-APPchr21

27372497

-
5CDS-intronENST00000441802ENST00000474136FAT1chr4

187627717

-APPchr21

27372497

-
intron-3CDSENST00000512347ENST00000346798FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000354192FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000348990FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000357903FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000358918FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000359726FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000448388FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000440126FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000439274FAT1chr4

187627717

-APPchr21

27372497

-
intron-intronENST00000512347ENST00000474136FAT1chr4

187627717

-APPchr21

27372497

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441802FAT1chr4187627717-ENST00000346798APPchr2127372497-6043347521049221570

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441802ENST00000346798FAT1chr4187627717-APPchr2127372497-0.000452420.99954754

Top

Fusion Genomic Features for FAT1-APP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FAT1-APP


check button Go to

FGviewer for the breakpoints of chr4:187627717-chr21:27372497

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAT1

Q14517

APP

Q8NEU8

FUNCTION: [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227150_2571088.33333333333334589.0DomainCadherin 2
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-22735_1491088.33333333333334589.0DomainCadherin 1
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227368_4631088.33333333333334589.0DomainCadherin 3
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227464_5691088.33333333333334589.0DomainCadherin 4
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227570_6731088.33333333333334589.0DomainCadherin 5
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227718_8221088.33333333333334589.0DomainCadherin 6
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227823_9271088.33333333333334589.0DomainCadherin 7
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-227928_10341088.33333333333334589.0DomainCadherin 8
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016230_2600696.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016274_2800696.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015230_2600640.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015274_2800640.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017230_2600715.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017274_2800715.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518374_565288.3333333333333771.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST0000034899001628_1890696.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016374_5650696.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST0000035419201528_1890640.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015374_5650640.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517374_565288.3333333333333752.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517374_565288.3333333333333753.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST0000035972601728_1890715.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017374_5650715.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517374_565283.3333333333333747.0DomainE2
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518344_365288.3333333333333771.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518724_734288.3333333333333771.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016344_3650696.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016724_7340696.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015344_3650640.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015724_7340640.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517344_365288.3333333333333752.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517724_734288.3333333333333752.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517344_365288.3333333333333753.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517724_734288.3333333333333753.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017344_3650715.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017724_7340715.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517344_365283.3333333333333747.0MotifOX-2
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517724_734283.3333333333333747.0MotifNote=Basolateral sorting signal
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518391_423288.3333333333333771.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518491_522288.3333333333333771.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518523_540288.3333333333333771.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016131_1890696.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016181_1880696.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000034899001628_1230696.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016391_4230696.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016491_5220696.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016523_5400696.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000034899001696_1100696.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015131_1890640.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015181_1880640.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035419201528_1230640.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015391_4230640.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015491_5220640.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015523_5400640.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035419201596_1100640.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517391_423288.3333333333333752.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517491_522288.3333333333333752.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517523_540288.3333333333333752.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517391_423288.3333333333333753.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517491_522288.3333333333333753.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517523_540288.3333333333333753.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017131_1890715.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017181_1880715.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035972601728_1230715.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017391_4230715.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017491_5220715.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017523_5400715.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035972601796_1100715.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517391_423283.3333333333333747.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517491_522283.3333333333333747.0RegionNote=Heparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517523_540283.3333333333333747.0RegionCollagen-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518723_770288.3333333333333771.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST0000034899001618_7010696.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016723_7700696.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST0000035419201518_7010640.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015723_7700640.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517723_770288.3333333333333752.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517723_770288.3333333333333753.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST0000035972601718_7010715.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017723_7700715.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517723_770283.3333333333333747.0Topological domainCytoplasmic
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518702_722288.3333333333333771.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016702_7220696.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015702_7220640.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517702_722288.3333333333333752.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517702_722288.3333333333333753.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017702_7220715.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517702_722283.3333333333333747.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271035_11391088.33333333333334589.0DomainCadherin 9
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271140_12451088.33333333333334589.0DomainCadherin 10
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271246_13571088.33333333333334589.0DomainCadherin 11
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271359_14561088.33333333333334589.0DomainCadherin 12
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271457_15621088.33333333333334589.0DomainCadherin 13
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271563_16671088.33333333333334589.0DomainCadherin 14
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271668_17651088.33333333333334589.0DomainCadherin 15
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271766_18791088.33333333333334589.0DomainCadherin 16
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271880_19791088.33333333333334589.0DomainCadherin 17
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2271980_20811088.33333333333334589.0DomainCadherin 18
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272082_21821088.33333333333334589.0DomainCadherin 19
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272183_22831088.33333333333334589.0DomainCadherin 20
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272284_23901088.33333333333334589.0DomainCadherin 21
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272391_24921088.33333333333334589.0DomainCadherin 22
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272493_25961088.33333333333334589.0DomainCadherin 23
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272597_27031088.33333333333334589.0DomainCadherin 24
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272704_28091088.33333333333334589.0DomainCadherin 25
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272810_29181088.33333333333334589.0DomainCadherin 26
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2272919_30231088.33333333333334589.0DomainCadherin 27
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273024_31251088.33333333333334589.0DomainCadherin 28
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273126_32301088.33333333333334589.0DomainCadherin 29
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273231_33351088.33333333333334589.0DomainCadherin 30
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273336_34401088.33333333333334589.0DomainCadherin 31
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273441_35451088.33333333333334589.0DomainCadherin 32
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273546_36471088.33333333333334589.0DomainCadherin 33
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273790_38271088.33333333333334589.0DomainEGF-like 1
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2273829_40091088.33333333333334589.0DomainLaminin G-like
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274013_40501088.33333333333334589.0DomainEGF-like 2
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274052_40881088.33333333333334589.0DomainEGF-like 3
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274089_41251088.33333333333334589.0DomainEGF-like 4
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274127_41631088.33333333333334589.0DomainEGF-like 5%3B calcium-binding
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274204_42141088.33333333333334589.0MotifNuclear localization signal
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274378_43821088.33333333333334589.0MotifPTB-like motif
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-22722_41811088.33333333333334589.0Topological domainExtracellular
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274203_45881088.33333333333334589.0Topological domainCytoplasmic
HgeneFAT1chr4:187627717chr21:27372497ENST00000441802-2274182_42021088.33333333333334589.0TransmembraneHelical
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518230_260288.3333333333333771.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518274_280288.3333333333333771.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517230_260288.3333333333333752.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517274_280288.3333333333333752.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517230_260288.3333333333333753.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517274_280288.3333333333333753.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517230_260283.3333333333333747.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517274_280283.3333333333333747.0Compositional biasNote=Poly-Thr
TgeneAPPchr4:187627717chr21:27372497ENST0000034679851828_189288.3333333333333771.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST0000035790351728_189288.3333333333333752.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST0000035891851728_189288.3333333333333753.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST0000044012651728_189283.3333333333333747.0DomainE1
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518131_189288.3333333333333771.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518181_188288.3333333333333771.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000034679851828_123288.3333333333333771.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST0000034679851896_110288.3333333333333771.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517131_189288.3333333333333752.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517181_188288.3333333333333752.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035790351728_123288.3333333333333752.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST0000035790351796_110288.3333333333333752.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517131_189288.3333333333333753.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517181_188288.3333333333333753.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000035891851728_123288.3333333333333753.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST0000035891851796_110288.3333333333333753.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517131_189283.3333333333333747.0RegionCuBD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517181_188283.3333333333333747.0RegionNote=Zinc-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000044012651728_123283.3333333333333747.0RegionGFLD subdomain
TgeneAPPchr4:187627717chr21:27372497ENST0000044012651796_110283.3333333333333747.0RegionHeparin-binding
TgeneAPPchr4:187627717chr21:27372497ENST0000034679851818_701288.3333333333333771.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST0000035790351718_701288.3333333333333752.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST0000035891851718_701288.3333333333333753.0Topological domainExtracellular
TgeneAPPchr4:187627717chr21:27372497ENST0000044012651718_701283.3333333333333747.0Topological domainExtracellular


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Fusion Gene Sequence for FAT1-APP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000441802_ENST00000346798_TCGA-PC-A5DN-01A_FAT1_chr4_187627717_-_APP_chr21_27372497_length(transcript)=6043nt_BP=3475nt
AGCGTGAGGCGCCGGCGCCGAGCTGGGCGGCCGGGCGCGGGGAGAGGGCGCGGGAGCGGCTCGTGCGGCAGGTACCATGCGGACGCGCGA
GCCCGGCGAGGGCCCCGGCAGGCCCGGTCCCTGCTCGGGGGCGCGCTGAGACGGCGGGTGAGCTCCACGAGAGCGCCGTCGCCACTTCGG
GCCAACTTTGCGATTCCCGACAGTTAAGCAATGGGGAGACATTTGGCTTTGCTCCTGCTTCTGCTCCTTCTCTTCCAACATTTTGGAGAC
AGTGATGGCAGCCAACGACTTGAACAGACTCCTCTGCAGTTTACACACCTCGAGTACAACGTCACCGTGCAGGAGAACTCTGCAGCTAAG
ACTTATGTGGGGCATCCTGTCAAGATGGGTGTTTACATTACACATCCAGCGTGGGAAGTAAGGTACAAAATTGTTTCCGGAGACAGTGAA
AACCTGTTCAAAGCTGAAGAGTACATTCTCGGAGACTTTTGCTTTCTAAGAATAAGGACCAAAGGAGGAAATACAGCTATTCTTAATAGA
GAAGTGAAGGATCACTACACATTGATAGTGAAAGCACTTGAAAAAAATACTAATGTGGAGGCGCGAACAAAGGTCAGGGTGCAGGTGCTG
GATACAAATGACTTGAGACCGTTATTCTCACCCACCTCATACAGCGTTTCTTTACCTGAAAACACAGCTATAAGGACCAGTATCGCAAGA
GTCAGCGCCACGGATGCAGACATAGGAACCAACGGGGAATTTTACTACAGTTTTAAAGATCGAACAGATATGTTTGCTATTCACCCAACC
AGTGGTGTGATAGTGTTAACTGGTAGACTTGATTACCTAGAGACCAAGCTCTATGAGATGGAAATCCTCGCTGCGGACCGTGGCATGAAG
TTGTATGGGAGCAGTGGCATCAGCAGCATGGCCAAGCTAACGGTGCACATCGAACAGGCCAATGAATGTGCTCCGGTGATAACAGCAGTG
ACATTGTCACCATCAGAACTGGACAGGGACCCAGCATATGCAATTGTGACAGTGGATGACTGCGATCAGGGTGCCAATGGTGACATAGCA
TCTTTAAGCATCGTGGCAGGTGACCTTCTCCAGCAGTTTAGAACAGTGAGGTCCTTTCCAGGGAGTAAGGAGTATAAAGTCAAAGCCATC
GGTGGCATTGATTGGGACAGTCATCCTTTCGGCTACAATCTCACACTACAGGCTAAAGATAAAGGAACTCCGCCCCAGTTCTCTTCTGTT
AAAGTCATTCACGTGACTTCTCCACAGTTCAAAGCCGGGCCAGTCAAGTTTGAAAAGGATGTTTACAGAGCAGAAATAAGTGAATTTGCT
CCTCCCAACACACCTGTGGTCATGGTAAAGGCCATTCCTGCTTATTCCCATTTGAGGTATGTTTTTAAAAGTACACCTGGAAAAGCTAAA
TTCAGTTTAAATTACAACACTGGTCTCATTTCTATTTTAGAACCAGTTAAAAGACAGCAGGCAGCCCATTTTGAACTTGAAGTAACAACA
AGTGACAGAAAAGCGTCCACCAAGGTCTTGGTGAAAGTCTTAGGTGCAAATAGCAATCCCCCTGAATTTACCCAGACAGCGTACAAAGCT
GCTTTTGATGAGAACGTGCCCATTGGTACTACTGTCATGAGCCTGAGTGCCGTAGACCCTGATGAGGGTGAGAACGGGTACGTGACATAC
AGTATCGCAAATTTAAATCATGTGCCGTTTGCGATTGACCATTTCACTGGTGCCGTGAGTACGTCAGAAAACCTGGACTACGAACTGATG
CCTCGGGTTTATACTCTGAGGATTCGTGCATCAGACTGGGGCTTGCCGTACCGCCGGGAAGTCGAAGTCCTTGCTACAATTACTCTCAAT
AACTTGAATGACAACACACCTTTGTTTGAGAAAATAAATTGTGAAGGGACAATTCCCAGAGATCTAGGCGTGGGAGAGCAAATAACCACT
GTTTCTGCTATTGATGCAGATGAACTTCAGTTGGTACAGTATCAGATTGAAGCTGGAAATGAACTGGATTTCTTTAGTTTAAACCCCAAC
TCGGGGGTATTGTCATTAAAGCGATCGCTAATGGATGGCTTAGGTGCAAAGGTGTCTTTCCACAGTCTGAGAATCACAGCTACAGATGGA
GAAAATTTTGCCACACCATTATATATCAACATAACAGTGGCTGCCAGTCACAAGCTGGTAAACTTGCAGTGTGAAGAGACTGGTGTTGCC
AAAATGCTGGCAGAGAAGCTCCTGCAGGCAAATAAATTACACAACCAGGGAGAGGTGGAGGATATTTTCTTCGATTCTCACTCTGTCAAT
GCTCACATACCGCAGTTTAGAAGCACTCTTCCGACTGGTATTCAGGTAAAGGAAAACCAGCCTGTGGGTTCCAGTGTAATTTTCATGAAC
TCCACTGACCTTGACACTGGCTTCAATGGAAAACTGGTCTATGCTGTTTCTGGAGGAAATGAGGATAGTTGCTTCATGATTGATATGGAA
ACAGGAATGCTGAAAATTTTATCTCCTCTTGACCGTGAAACAACAGACAAATACACCCTGAATATTACCGTCTATGACCTTGGGATACCC
CAGAAGGCTGCGTGGCGTCTTCTACATGTCGTGGTTGTCGATGCCAATGATAATCCACCCGAGTTTTTACAGGAGAGCTATTTTGTGGAA
GTGAGTGAAGACAAGGAGGTACATAGTGAAATCATCCAGGTTGAAGCCACAGATAAAGACCTGGGGCCCAACGGACACGTGACGTACTCA
ATTGTTACAGACACAGACACATTTTCAATTGACAGCGTGACGGGTGTTGTTAACATCGCACGCCCTCTGGATCGAGAGCTGCAGCATGAG
CACTCCTTAAAGATTGAGGCCAGGGACCAAGCCAGAGAAGAGCCTCAGCTGTTCTCCACTGTCGTTGTGAAAGTATCACTAGAAGATGTT
AATGACAACCCACCTACATTTATTCCACCTAATTATCGTGTGAAAGTCCGAGAGGATCTTCCAGAAGGAACCGTCATCATGTGGTTAGAA
GCCCACGATCCTGATTTAGGTCAGTCTGGTCAGGTGAGATACAGCCTTCTGGACCACGGAGAAGGAAACTTCGATGTGGATAAACTCAGT
GGAGCAGTTAGGATCGTCCAGCAGTTGGACTTTGAGAAGAAGCAAGTGTATAATCTCACTGTGAGGGCCAAAGACAAGGGAAAGCCAGTT
TCTCTGTCTTCTACTTGCTATGTTGAAGTTGAGGTGGTTGATGTGAATGAGAACCTGCACCCACCCGTGTTTTCCAGCTTTGTGGAAAAG
GGGACAGTGAAAGAAGATGCACCTGTTGGTTCATTGGTAATGACGGTGTCGGCTCATGATGAGGACGCCAGAAGAGATGGGGAGATCCGA
TACTCCATTAGAGATGGCTCTGGCGTTGGTGTTTTCAAAATAGGTGAAGAGACAGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGC
CGAGCAATGATCTCCCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGCGGATGTGGCGGCAACCGGAACAAC
TTTGACACAGAAGAGTACTGCATGGCCGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACCTCTTGCCCGAGAT
CCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGATGCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCAT
TTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCA
AAGAACTTGCCTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTTTGGAACAGGAAGCAGCCAACGAGAGA
CAGCAGCTGGTGGAGACACACATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAGAACTACATCACCGCTCTG
CAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCAATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACCCTAAAG
CATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGC
ATGAATCAGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGGATGAAGTTGATGAGCTGCTTCAGAAAGAGCAA
AACTATTCAGATGACGTCTTGGCCAACATGATTAGTGAACCAAGGATCAGTTACGGAAACGATGCTCTCATGCCATCTTTGACCGAAACG
AAAACCACCGTGGAGCTCCTTCCCGTGAATGGAGAGTTCAGCCTGGACGATCTCCAGCCGTGGCATTCTTTTGGGGCTGACTCTGTGCCA
GCCAACACAGAAAACGAAGTTGAGCCTGTTGATGCCCGCCCTGCTGCCGACCGAGGACTGACCACTCGACCAGGTTCTGGGTTGACAAAT
ATCAAGACGGAGGAGATCTCTGAAGTGAAGATGGATGCAGAATTCCGACATGACTCAGGATATGAAGTTCATCATCAAAAATTGGTGTTC
TTTGCAGAAGATGTGGGTTCAAACAAAGGTGCAATCATTGGACTCATGGTGGGCGGTGTTGTCATAGCGACAGTGATCGTCATCACCTTG
GTGATGCTGAAGAAGAAACAGTACACATCCATTCATCATGGTGTGGTGGAGGTTGACGCCGCTGTCACCCCAGAGGAGCGCCACCTGTCC
AAGATGCAGCAGAACGGCTACGAAAATCCAACCTACAAGTTCTTTGAGCAGATGCAGAACTAGACCCCCGCCACAGCAGCCTCTGAAGTT
GGACAGCAAAACCATTGCTTCACTACCCATCGGTGTCCATTTATAGAATAATGTGGGAAGAAACAAACCCGTTTTATGATTTACTCATTA
TCGCCTTTTGACAGCTGTGCTGTAACACAAGTAGATGCCTGAACTTGAATTAATCCACACATCAGTAATGTATTCTATCTCTCTTTACAT
TTTGGTCTCTATACTACATTATTAATGGGTTTTGTGTACTGTAAAGAATTTAGCTGTATCAAACTAGTGCATGAATAGATTCTCTCCTGA
TTATTTATCACATAGCCCCTTAGCCAGTTGTATATTATTCTTGTGGTTTGTGACCCAATTAAGTCCTACTTTACATATGCTTTAAGAATC
GATGGGGGATGCTTCATGTGAACGTGGGAGTTCAGCTGCTTCTCTTGCCTAAGTATTCCTTTCCTGATCACTATGCATTTTAAAGTTAAA
CATTTTTAAGTATTTCAGATGCTTTAGAGAGATTTTTTTTCCATGACTGCATTTTACTGTACAGATTGCTGCTTCTGCTATATTTGTGAT
ATAGGAATTAAGAGGATACACACGTTTGTTTCTTCGTGCCTGTTTTATGTGCACACATTAGGCATTGAGACTTCAAGCTTTTCTTTTTTT
GTCCACGTATCTTTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTGGGGAGGGGTGCTCTGCTG
GTCTTCAATTACCAAGAATTCTCCAAAACAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGACATGATCGCTTTCTACACTGT
ATTACATAAATAAATTAAATAAAATAACCCCGGGCAAGACTTTTCTTTGAAGGATGACTACAGACATTAAATAATCGAAGTAATTTTGGG
TGGGGAGAAGAGGCAGATTCAATTTTCTTTAACCAGTCTGAAGTTTCATTTATGATACAAAAGAAGATGAAAATGGAAGTGGCAATATAA
GGGGATGAGGAAGGCATGCCTGGACAAACCCTTCTTTTAAGATGTGTCTTCAATTTGTATAAAATGGTGTTTTCATGTAAATAAATACAT

>In-frame_ENST00000441802_ENST00000346798_TCGA-PC-A5DN-01A_FAT1_chr4_187627717_-_APP_chr21_27372497_length(amino acids)=1570AA_start in transcript=210_stop in transcript=4922
MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYIL
GDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGT
NGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRD
PAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQF
KAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL
VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRA
SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSL
MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTL
PTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHV
VVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ
AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD
FEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVG
VFKIGEETEVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAAS
TPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMAR
VEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYN
VPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPV
DARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAT1-APP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518732_751288.3333333333333771.0G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016732_7510696.0G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015732_7510640.0G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517732_751288.3333333333333752.0G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517732_751288.3333333333333753.0G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017732_7510715.0G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517732_751283.3333333333333747.0G(o)-alpha
TgeneAPPchr4:187627717chr21:27372497ENST00000346798518695_722288.3333333333333771.0PSEN1
TgeneAPPchr4:187627717chr21:27372497ENST00000348990016695_7220696.0PSEN1
TgeneAPPchr4:187627717chr21:27372497ENST00000354192015695_7220640.0PSEN1
TgeneAPPchr4:187627717chr21:27372497ENST00000357903517695_722288.3333333333333752.0PSEN1
TgeneAPPchr4:187627717chr21:27372497ENST00000358918517695_722288.3333333333333753.0PSEN1
TgeneAPPchr4:187627717chr21:27372497ENST00000359726017695_7220715.0PSEN1
TgeneAPPchr4:187627717chr21:27372497ENST00000440126517695_722283.3333333333333747.0PSEN1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAT1-APP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAT1-APP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAT1C0009402Colorectal Carcinoma1CTD_human
HgeneFAT1C0009404Colorectal Neoplasms1CTD_human
HgeneFAT1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneFAT1C0017636Glioblastoma1CTD_human
HgeneFAT1C0018671Head and Neck Neoplasms1CTD_human
HgeneFAT1C0018675Head Neoplasms1CTD_human
HgeneFAT1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFAT1C0027533Neck Neoplasms1CTD_human
HgeneFAT1C0036095Salivary Gland Neoplasms1CTD_human
HgeneFAT1C0220636Malignant neoplasm of salivary gland1CTD_human
HgeneFAT1C0278996Malignant Head and Neck Neoplasm1CTD_human
HgeneFAT1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneFAT1C0334588Giant Cell Glioblastoma1CTD_human
HgeneFAT1C0746787Cancer of Neck1CTD_human
HgeneFAT1C0751177Cancer of Head1CTD_human
HgeneFAT1C0887900Upper Aerodigestive Tract Neoplasms1CTD_human
HgeneFAT1C1621958Glioblastoma Multiforme1CTD_human
TgeneAPPC0002395Alzheimer's Disease63CTD_human;UNIPROT
TgeneAPPC0011265Presenile dementia35CTD_human
TgeneAPPC0276496Familial Alzheimer Disease (FAD)35CTD_human
TgeneAPPC0494463Alzheimer Disease, Late Onset35CTD_human
TgeneAPPC0546126Acute Confusional Senile Dementia35CTD_human
TgeneAPPC0750900Alzheimer's Disease, Focal Onset35CTD_human
TgeneAPPC0750901Alzheimer Disease, Early Onset35CTD_human
TgeneAPPC0025261Memory Disorders16CTD_human
TgeneAPPC0233794Memory impairment16CTD_human
TgeneAPPC0751292Age-Related Memory Disorders16CTD_human
TgeneAPPC0751293Memory Disorder, Semantic16CTD_human
TgeneAPPC0751294Memory Disorder, Spatial16CTD_human
TgeneAPPC0751295Memory Loss16CTD_human
TgeneAPPC0027746Nerve Degeneration11CTD_human
TgeneAPPC0023186Learning Disorders8CTD_human
TgeneAPPC0751262Adult Learning Disorders8CTD_human
TgeneAPPC0751263Learning Disturbance8CTD_human
TgeneAPPC0751265Learning Disabilities8CTD_human
TgeneAPPC1330966Developmental Academic Disorder8CTD_human
TgeneAPPC2751536CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED7CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneAPPC0009241Cognition Disorders5CTD_human
TgeneAPPC0011570Mental Depression5PSYGENET
TgeneAPPC0011581Depressive disorder5PSYGENET
TgeneAPPC0234544Todd Paralysis5CTD_human
TgeneAPPC0522224Paralysed5CTD_human
TgeneAPPC0497327Dementia3CTD_human;GENOMICS_ENGLAND
TgeneAPPC2931672Cerebral hemorrhage with amyloidosis, hereditary, Dutch type3CTD_human;ORPHANET
TgeneAPPC0270715Degenerative Diseases, Central Nervous System2CTD_human
TgeneAPPC0333463Senile Plaques2CTD_human
TgeneAPPC0524851Neurodegenerative Disorders2CTD_human
TgeneAPPC0600467Neurogenic Inflammation2CTD_human
TgeneAPPC0751733Degenerative Diseases, Spinal Cord2CTD_human
TgeneAPPC2751494CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ARCTIC VARIANT2CTD_human
TgeneAPPC2936349Plaque, Amyloid2CTD_human
TgeneAPPC3888307CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, FLEMISH VARIANT2CTD_human
TgeneAPPC3888308CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, ITALIAN VARIANT2CTD_human
TgeneAPPC3888309CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, IOWA VARIANT2CTD_human
TgeneAPPC0002622Amnesia1CTD_human
TgeneAPPC0002726Amyloidosis1CTD_human
TgeneAPPC0003469Anxiety Disorders1CTD_human
TgeneAPPC0005586Bipolar Disorder1PSYGENET
TgeneAPPC0006111Brain Diseases1CTD_human
TgeneAPPC0011573Endogenous depression1PSYGENET
TgeneAPPC0016667Fragile X Syndrome1CTD_human
TgeneAPPC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneAPPC0027540Necrosis1CTD_human
TgeneAPPC0033141Cardiomyopathies, Primary1CTD_human
TgeneAPPC0036529Myocardial Diseases, Secondary1CTD_human
TgeneAPPC0036572Seizures1GENOMICS_ENGLAND
TgeneAPPC0037928Spinal Cord Diseases1CTD_human
TgeneAPPC0038002Splenomegaly1CTD_human
TgeneAPPC0038454Cerebrovascular accident1GENOMICS_ENGLAND
TgeneAPPC0043094Weight Gain1CTD_human
TgeneAPPC0085220Cerebral Amyloid Angiopathy1CTD_human
TgeneAPPC0085584Encephalopathies1CTD_human
TgeneAPPC0231341Premature aging syndrome1CTD_human
TgeneAPPC0233750Hysterical amnesia1CTD_human
TgeneAPPC0233796Temporary Amnesia1CTD_human
TgeneAPPC0234985Mental deterioration1CTD_human
TgeneAPPC0236795Dissociative Amnesia1CTD_human
TgeneAPPC0262497Global Amnesia1CTD_human
TgeneAPPC0270612Leukoencephalopathy1GENOMICS_ENGLAND
TgeneAPPC0338582Sporadic Cerebral Amyloid Angiopathy1CTD_human
TgeneAPPC0338630Senile Paranoid Dementia1CTD_human
TgeneAPPC0338656Impaired cognition1CTD_human
TgeneAPPC0376280Anxiety States, Neurotic1CTD_human
TgeneAPPC0553692Brain hemorrhage1GENOMICS_ENGLAND
TgeneAPPC0750906Tactile Amnesia1CTD_human
TgeneAPPC0750907Amnestic State1CTD_human
TgeneAPPC0751071Familial Dementia1CTD_human
TgeneAPPC0751156FRAXA Syndrome1CTD_human
TgeneAPPC0751157FRAXE Syndrome1CTD_human
TgeneAPPC0878544Cardiomyopathies1CTD_human
TgeneAPPC0948008Ischemic stroke1GENOMICS_ENGLAND
TgeneAPPC1270972Mild cognitive disorder1CTD_human
TgeneAPPC1279420Anxiety neurosis (finding)1CTD_human