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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAT3-FAT3 (FusionGDB2 ID:29392)

Fusion Gene Summary for FAT3-FAT3

check button Fusion gene summary
Fusion gene informationFusion gene name: FAT3-FAT3
Fusion gene ID: 29392
HgeneTgene
Gene symbol

FAT3

FAT3

Gene ID

120114

120114

Gene nameFAT atypical cadherin 3FAT atypical cadherin 3
SynonymsCDHF15|CDHR10|hFat3CDHF15|CDHR10|hFat3
Cytomap

11q14.3

11q14.3

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin Fat 3FAT tumor suppressor homolog 3cadherin family member 15cadherin-related family member 10protocadherin Fat 3FAT tumor suppressor homolog 3cadherin family member 15cadherin-related family member 10
Modification date2020031320200313
UniProtAcc

Q8TDW7

Q8TDW7

Ensembl transtripts involved in fusion geneENST00000541502, ENST00000409404, 
ENST00000298047, ENST00000525166, 
ENST00000533797, ENST00000489716, 
ENST00000541502, ENST00000409404, 
ENST00000298047, ENST00000525166, 
ENST00000533797, ENST00000489716, 
Fusion gene scores* DoF score10 X 9 X 3=27011 X 11 X 4=484
# samples 1011
** MAII scorelog2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/484*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAT3 [Title/Abstract] AND FAT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAT3(92086282)-FAT3(92088272), # samples:1
Anticipated loss of major functional domain due to fusion event.FAT3-FAT3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FAT3-FAT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FAT3-FAT3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FAT3-FAT3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FAT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF476342FAT3chr11

92086282

-FAT3chr11

92088272

-


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Fusion Gene ORF analysis for FAT3-FAT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000541502ENST00000541502FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000541502ENST00000409404FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000541502ENST00000298047FAT3chr11

92086282

-FAT3chr11

92088272

-
Frame-shiftENST00000541502ENST00000525166FAT3chr11

92086282

-FAT3chr11

92088272

-
5CDS-intronENST00000541502ENST00000533797FAT3chr11

92086282

-FAT3chr11

92088272

-
5CDS-intronENST00000541502ENST00000489716FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000409404ENST00000541502FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000409404ENST00000409404FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000409404ENST00000298047FAT3chr11

92086282

-FAT3chr11

92088272

-
Frame-shiftENST00000409404ENST00000525166FAT3chr11

92086282

-FAT3chr11

92088272

-
5CDS-intronENST00000409404ENST00000533797FAT3chr11

92086282

-FAT3chr11

92088272

-
5CDS-intronENST00000409404ENST00000489716FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000298047ENST00000541502FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000298047ENST00000409404FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000298047ENST00000298047FAT3chr11

92086282

-FAT3chr11

92088272

-
Frame-shiftENST00000298047ENST00000525166FAT3chr11

92086282

-FAT3chr11

92088272

-
5CDS-intronENST00000298047ENST00000533797FAT3chr11

92086282

-FAT3chr11

92088272

-
5CDS-intronENST00000298047ENST00000489716FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000525166ENST00000541502FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000525166ENST00000409404FAT3chr11

92086282

-FAT3chr11

92088272

-
In-frameENST00000525166ENST00000298047FAT3chr11

92086282

-FAT3chr11

92088272

-
Frame-shiftENST00000525166ENST00000525166FAT3chr11

92086282

-FAT3chr11

92088272

-
5CDS-intronENST00000525166ENST00000533797FAT3chr11

92086282

-FAT3chr11

92088272

-
5CDS-intronENST00000525166ENST00000489716FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-3CDSENST00000533797ENST00000541502FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-3CDSENST00000533797ENST00000409404FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-3CDSENST00000533797ENST00000298047FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-3CDSENST00000533797ENST00000525166FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-intronENST00000533797ENST00000533797FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-intronENST00000533797ENST00000489716FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-3CDSENST00000489716ENST00000541502FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-3CDSENST00000489716ENST00000409404FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-3CDSENST00000489716ENST00000298047FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-3CDSENST00000489716ENST00000525166FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-intronENST00000489716ENST00000533797FAT3chr11

92086282

-FAT3chr11

92088272

-
intron-intronENST00000489716ENST00000489716FAT3chr11

92086282

-FAT3chr11

92088272

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FAT3-FAT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FAT3-FAT3


check button Go to

FGviewer for the breakpoints of chr11:92086282-chr11:92088272

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAT3

Q8TDW7

FAT3

Q8TDW7

FUNCTION: May play a role in the interactions between neurites derived from specific subsets of neurons during development. {ECO:0000250}.FUNCTION: May play a role in the interactions between neurites derived from specific subsets of neurons during development. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470274406_447704590.0Compositional biasNote=Pro-rich
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040254406_447704558.0Compositional biasNote=Pro-rich
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470271044_114804590.0DomainCadherin 10
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470271149_125404590.0DomainCadherin 11
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470271255_135904590.0DomainCadherin 12
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470271363_146004590.0DomainCadherin 13
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470271461_156604590.0DomainCadherin 14
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470271567_176904590.0DomainCadherin 15
TgeneFAT3chr11:92086282chr11:92088272ENST00000298047027159_26604590.0DomainCadherin 2
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470271770_188304590.0DomainCadherin 16
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470271884_198604590.0DomainCadherin 17
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470271983_208404590.0DomainCadherin 18
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470272085_218604590.0DomainCadherin 19
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470272187_228704590.0DomainCadherin 20
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470272288_239404590.0DomainCadherin 21
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470272395_249604590.0DomainCadherin 22
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470272497_260004590.0DomainCadherin 23
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470272601_270804590.0DomainCadherin 24
TgeneFAT3chr11:92086282chr11:92088272ENST00000298047027264_37504590.0DomainCadherin 3
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470272709_281404590.0DomainCadherin 25
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470272815_292404590.0DomainCadherin 26
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470272925_302904590.0DomainCadherin 27
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470273030_313104590.0DomainCadherin 28
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470273132_323604590.0DomainCadherin 29
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470273237_334104590.0DomainCadherin 30
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470273342_344604590.0DomainCadherin 31
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470273447_355104590.0DomainCadherin 32
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470273552_365304590.0DomainCadherin 33
TgeneFAT3chr11:92086282chr11:92088272ENST00000298047027377_47204590.0DomainCadherin 4
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470273795_383304590.0DomainEGF-like 1
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470273835_401804590.0DomainLaminin G-like
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470274021_405804590.0DomainEGF-like 2
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470274060_409604590.0DomainEGF-like 3
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470274098_413404590.0DomainEGF-like 4%3B calcium-binding
TgeneFAT3chr11:92086282chr11:92088272ENST0000029804702744_15804590.0DomainCadherin 1
TgeneFAT3chr11:92086282chr11:92088272ENST00000298047027473_57804590.0DomainCadherin 5
TgeneFAT3chr11:92086282chr11:92088272ENST00000298047027579_68104590.0DomainCadherin 6
TgeneFAT3chr11:92086282chr11:92088272ENST00000298047027727_83104590.0DomainCadherin 7
TgeneFAT3chr11:92086282chr11:92088272ENST00000298047027832_93604590.0DomainCadherin 8
TgeneFAT3chr11:92086282chr11:92088272ENST00000298047027937_104304590.0DomainCadherin 9
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040251044_114804558.0DomainCadherin 10
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040251149_125404558.0DomainCadherin 11
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040251255_135904558.0DomainCadherin 12
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040251363_146004558.0DomainCadherin 13
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040251461_156604558.0DomainCadherin 14
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040251567_176904558.0DomainCadherin 15
TgeneFAT3chr11:92086282chr11:92088272ENST00000409404025159_26604558.0DomainCadherin 2
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040251770_188304558.0DomainCadherin 16
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040251884_198604558.0DomainCadherin 17
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040251983_208404558.0DomainCadherin 18
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040252085_218604558.0DomainCadherin 19
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040252187_228704558.0DomainCadherin 20
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040252288_239404558.0DomainCadherin 21
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040252395_249604558.0DomainCadherin 22
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040252497_260004558.0DomainCadherin 23
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040252601_270804558.0DomainCadherin 24
TgeneFAT3chr11:92086282chr11:92088272ENST00000409404025264_37504558.0DomainCadherin 3
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040252709_281404558.0DomainCadherin 25
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040252815_292404558.0DomainCadherin 26
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040252925_302904558.0DomainCadherin 27
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040253030_313104558.0DomainCadherin 28
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040253132_323604558.0DomainCadherin 29
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040253237_334104558.0DomainCadherin 30
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040253342_344604558.0DomainCadherin 31
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040253447_355104558.0DomainCadherin 32
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040253552_365304558.0DomainCadherin 33
TgeneFAT3chr11:92086282chr11:92088272ENST00000409404025377_47204558.0DomainCadherin 4
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040253795_383304558.0DomainEGF-like 1
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040253835_401804558.0DomainLaminin G-like
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040254021_405804558.0DomainEGF-like 2
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040254060_409604558.0DomainEGF-like 3
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040254098_413404558.0DomainEGF-like 4%3B calcium-binding
TgeneFAT3chr11:92086282chr11:92088272ENST0000040940402544_15804558.0DomainCadherin 1
TgeneFAT3chr11:92086282chr11:92088272ENST00000409404025473_57804558.0DomainCadherin 5
TgeneFAT3chr11:92086282chr11:92088272ENST00000409404025579_68104558.0DomainCadherin 6
TgeneFAT3chr11:92086282chr11:92088272ENST00000409404025727_83104558.0DomainCadherin 7
TgeneFAT3chr11:92086282chr11:92088272ENST00000409404025832_93604558.0DomainCadherin 8
TgeneFAT3chr11:92086282chr11:92088272ENST00000409404025937_104304558.0DomainCadherin 9
TgeneFAT3chr11:92086282chr11:92088272ENST0000029804702733_415404590.0Topological domainExtracellular
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470274176_455704590.0Topological domainCytoplasmic
TgeneFAT3chr11:92086282chr11:92088272ENST0000040940402533_415404558.0Topological domainExtracellular
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040254176_455704558.0Topological domainCytoplasmic
TgeneFAT3chr11:92086282chr11:92088272ENST000002980470274155_417504590.0TransmembraneHelical
TgeneFAT3chr11:92086282chr11:92088272ENST000004094040254155_417504558.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1274406_447704590.0Compositional biasNote=Pro-rich
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1254406_447704558.0Compositional biasNote=Pro-rich
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1271044_114804590.0DomainCadherin 10
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1271149_125404590.0DomainCadherin 11
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1271255_135904590.0DomainCadherin 12
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1271363_146004590.0DomainCadherin 13
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1271461_156604590.0DomainCadherin 14
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1271567_176904590.0DomainCadherin 15
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-127159_26604590.0DomainCadherin 2
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1271770_188304590.0DomainCadherin 16
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1271884_198604590.0DomainCadherin 17
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1271983_208404590.0DomainCadherin 18
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1272085_218604590.0DomainCadherin 19
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1272187_228704590.0DomainCadherin 20
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1272288_239404590.0DomainCadherin 21
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1272395_249604590.0DomainCadherin 22
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1272497_260004590.0DomainCadherin 23
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1272601_270804590.0DomainCadherin 24
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-127264_37504590.0DomainCadherin 3
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1272709_281404590.0DomainCadherin 25
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1272815_292404590.0DomainCadherin 26
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1272925_302904590.0DomainCadherin 27
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1273030_313104590.0DomainCadherin 28
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1273132_323604590.0DomainCadherin 29
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1273237_334104590.0DomainCadherin 30
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1273342_344604590.0DomainCadherin 31
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1273447_355104590.0DomainCadherin 32
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1273552_365304590.0DomainCadherin 33
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-127377_47204590.0DomainCadherin 4
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1273795_383304590.0DomainEGF-like 1
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1273835_401804590.0DomainLaminin G-like
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1274021_405804590.0DomainEGF-like 2
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1274060_409604590.0DomainEGF-like 3
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1274098_413404590.0DomainEGF-like 4%3B calcium-binding
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-12744_15804590.0DomainCadherin 1
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-127473_57804590.0DomainCadherin 5
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-127579_68104590.0DomainCadherin 6
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-127727_83104590.0DomainCadherin 7
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-127832_93604590.0DomainCadherin 8
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-127937_104304590.0DomainCadherin 9
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1251044_114804558.0DomainCadherin 10
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1251149_125404558.0DomainCadherin 11
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1251255_135904558.0DomainCadherin 12
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1251363_146004558.0DomainCadherin 13
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1251461_156604558.0DomainCadherin 14
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1251567_176904558.0DomainCadherin 15
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-125159_26604558.0DomainCadherin 2
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1251770_188304558.0DomainCadherin 16
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1251884_198604558.0DomainCadherin 17
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1251983_208404558.0DomainCadherin 18
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1252085_218604558.0DomainCadherin 19
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1252187_228704558.0DomainCadherin 20
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1252288_239404558.0DomainCadherin 21
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1252395_249604558.0DomainCadherin 22
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1252497_260004558.0DomainCadherin 23
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1252601_270804558.0DomainCadherin 24
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-125264_37504558.0DomainCadherin 3
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1252709_281404558.0DomainCadherin 25
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1252815_292404558.0DomainCadherin 26
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1252925_302904558.0DomainCadherin 27
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1253030_313104558.0DomainCadherin 28
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1253132_323604558.0DomainCadherin 29
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1253237_334104558.0DomainCadherin 30
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1253342_344604558.0DomainCadherin 31
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1253447_355104558.0DomainCadherin 32
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1253552_365304558.0DomainCadherin 33
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-125377_47204558.0DomainCadherin 4
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1253795_383304558.0DomainEGF-like 1
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1253835_401804558.0DomainLaminin G-like
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1254021_405804558.0DomainEGF-like 2
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1254060_409604558.0DomainEGF-like 3
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1254098_413404558.0DomainEGF-like 4%3B calcium-binding
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-12544_15804558.0DomainCadherin 1
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-125473_57804558.0DomainCadherin 5
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-125579_68104558.0DomainCadherin 6
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-125727_83104558.0DomainCadherin 7
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-125832_93604558.0DomainCadherin 8
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-125937_104304558.0DomainCadherin 9
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-12733_415404590.0Topological domainExtracellular
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1274176_455704590.0Topological domainCytoplasmic
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-12533_415404558.0Topological domainExtracellular
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1254176_455704558.0Topological domainCytoplasmic
HgeneFAT3chr11:92086282chr11:92088272ENST00000298047-1274155_417504590.0TransmembraneHelical
HgeneFAT3chr11:92086282chr11:92088272ENST00000409404-1254155_417504558.0TransmembraneHelical


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Fusion Gene Sequence for FAT3-FAT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FAT3-FAT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAT3-FAT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAT3-FAT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAT3C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneFAT3C0279626Squamous cell carcinoma of esophagus1CTD_human