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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXL20-CASS4 (FusionGDB2 ID:29555)

Fusion Gene Summary for FBXL20-CASS4

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL20-CASS4
Fusion gene ID: 29555
HgeneTgene
Gene symbol

FBXL20

CASS4

Gene ID

84961

57091

Gene nameF-box and leucine rich repeat protein 20Cas scaffold protein family member 4
SynonymsFbl2|Fbl20C20orf32|CAS4|HEFL|HEPL
Cytomap

17q12

20q13.31

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 20F-box protein FBL2cas scaffolding protein family member 4HEF-like proteinHEF1-EFS-p130Cas-like protein
Modification date2020031320200313
UniProtAcc

Q96IG2

Q9NQ75

Ensembl transtripts involved in fusion geneENST00000583610, ENST00000394294, 
ENST00000264658, ENST00000577399, 
ENST00000360314, ENST00000371336, 
ENST00000434344, 
Fusion gene scores* DoF score58 X 21 X 16=194887 X 5 X 4=140
# samples 618
** MAII scorelog2(61/19488*10)=-4.99763298545608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXL20 [Title/Abstract] AND CASS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXL20(37557614)-CASS4(55020956), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCASS4

GO:0061098

positive regulation of protein tyrosine kinase activity

18256281


check buttonFusion gene breakpoints across FBXL20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CASS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FV-01AFBXL20chr17

37557614

-CASS4chr20

55020956

+
ChimerDB4BRCATCGA-AN-A0FV-01AFBXL20chr17

37557614

-CASS4chr20

55020956

+


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Fusion Gene ORF analysis for FBXL20-CASS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000583610ENST00000360314FBXL20chr17

37557614

-CASS4chr20

55020956

+
In-frameENST00000583610ENST00000371336FBXL20chr17

37557614

-CASS4chr20

55020956

+
In-frameENST00000583610ENST00000434344FBXL20chr17

37557614

-CASS4chr20

55020956

+
In-frameENST00000394294ENST00000360314FBXL20chr17

37557614

-CASS4chr20

55020956

+
In-frameENST00000394294ENST00000371336FBXL20chr17

37557614

-CASS4chr20

55020956

+
In-frameENST00000394294ENST00000434344FBXL20chr17

37557614

-CASS4chr20

55020956

+
In-frameENST00000264658ENST00000360314FBXL20chr17

37557614

-CASS4chr20

55020956

+
In-frameENST00000264658ENST00000371336FBXL20chr17

37557614

-CASS4chr20

55020956

+
In-frameENST00000264658ENST00000434344FBXL20chr17

37557614

-CASS4chr20

55020956

+
intron-3CDSENST00000577399ENST00000360314FBXL20chr17

37557614

-CASS4chr20

55020956

+
intron-3CDSENST00000577399ENST00000371336FBXL20chr17

37557614

-CASS4chr20

55020956

+
intron-3CDSENST00000577399ENST00000434344FBXL20chr17

37557614

-CASS4chr20

55020956

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000583610FBXL20chr1737557614-ENST00000360314CASS4chr2055020956+22312962542197647
ENST00000583610FBXL20chr1737557614-ENST00000371336CASS4chr2055020956+27912962542197647
ENST00000583610FBXL20chr1737557614-ENST00000434344CASS4chr2055020956+1479296254886210
ENST00000394294FBXL20chr1737557614-ENST00000360314CASS4chr2055020956+21982632212164647
ENST00000394294FBXL20chr1737557614-ENST00000371336CASS4chr2055020956+27582632212164647
ENST00000394294FBXL20chr1737557614-ENST00000434344CASS4chr2055020956+1446263221853210
ENST00000264658FBXL20chr1737557614-ENST00000360314CASS4chr2055020956+22383032612204647
ENST00000264658FBXL20chr1737557614-ENST00000371336CASS4chr2055020956+27983032612204647
ENST00000264658FBXL20chr1737557614-ENST00000434344CASS4chr2055020956+1486303261893210

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000583610ENST00000360314FBXL20chr1737557614-CASS4chr2055020956+0.0181975530.9818024
ENST00000583610ENST00000371336FBXL20chr1737557614-CASS4chr2055020956+0.0138016790.98619837
ENST00000583610ENST00000434344FBXL20chr1737557614-CASS4chr2055020956+0.024673950.97532606
ENST00000394294ENST00000360314FBXL20chr1737557614-CASS4chr2055020956+0.018629930.98137003
ENST00000394294ENST00000371336FBXL20chr1737557614-CASS4chr2055020956+0.0143038750.9856961
ENST00000394294ENST00000434344FBXL20chr1737557614-CASS4chr2055020956+0.0198675280.9801325
ENST00000264658ENST00000360314FBXL20chr1737557614-CASS4chr2055020956+0.0179150460.98208493
ENST00000264658ENST00000371336FBXL20chr1737557614-CASS4chr2055020956+0.0135128370.9864871
ENST00000264658ENST00000434344FBXL20chr1737557614-CASS4chr2055020956+0.0207522940.9792477

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Fusion Genomic Features for FBXL20-CASS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXL20chr1737557613-CASS4chr2055020955+6.78E-070.9999993
FBXL20chr1737557613-CASS4chr2055020955+6.78E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBXL20-CASS4


check button Go to

FGviewer for the breakpoints of chr17:37557614-chr20:55020956

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL20

Q96IG2

CASS4

Q9NQ75

FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.FUNCTION: Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCASS4chr17:37557614chr20:55020956ENST0000036031427274_277153.0787.0Compositional biasNote=Poly-Ser
TgeneCASS4chr17:37557614chr20:55020956ENST0000036031427373_429153.0787.0Compositional biasNote=Ser-rich
TgeneCASS4chr17:37557614chr20:55020956ENST0000037133616274_277153.0787.0Compositional biasNote=Poly-Ser
TgeneCASS4chr17:37557614chr20:55020956ENST0000037133616373_429153.0787.0Compositional biasNote=Ser-rich
TgeneCASS4chr17:37557614chr20:55020956ENST0000043434415274_277153.0350.0Compositional biasNote=Poly-Ser
TgeneCASS4chr17:37557614chr20:55020956ENST0000043434415373_429153.0350.0Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-11522_6814.0437.0DomainF-box
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-11422_6814.0405.0DomainF-box
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-11622_6814.0411.6666666666667DomainF-box
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115101_12614.0437.0RepeatNote=LRR 2
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115127_15214.0437.0RepeatNote=LRR 3
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115153_17814.0437.0RepeatNote=LRR 4
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115179_20414.0437.0RepeatNote=LRR 5
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115205_23014.0437.0RepeatNote=LRR 6
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115231_25614.0437.0RepeatNote=LRR 7
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115257_28214.0437.0RepeatNote=LRR 8
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115283_30814.0437.0RepeatNote=LRR 9
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115309_33414.0437.0RepeatNote=LRR 10
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115335_36314.0437.0RepeatNote=LRR 11
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115364_38814.0437.0RepeatNote=LRR 12
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-115389_41414.0437.0RepeatNote=LRR 13
HgeneFBXL20chr17:37557614chr20:55020956ENST00000264658-11574_10014.0437.0RepeatNote=LRR 1
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114101_12614.0405.0RepeatNote=LRR 2
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114127_15214.0405.0RepeatNote=LRR 3
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114153_17814.0405.0RepeatNote=LRR 4
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114179_20414.0405.0RepeatNote=LRR 5
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114205_23014.0405.0RepeatNote=LRR 6
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114231_25614.0405.0RepeatNote=LRR 7
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114257_28214.0405.0RepeatNote=LRR 8
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114283_30814.0405.0RepeatNote=LRR 9
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114309_33414.0405.0RepeatNote=LRR 10
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114335_36314.0405.0RepeatNote=LRR 11
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114364_38814.0405.0RepeatNote=LRR 12
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-114389_41414.0405.0RepeatNote=LRR 13
HgeneFBXL20chr17:37557614chr20:55020956ENST00000394294-11474_10014.0405.0RepeatNote=LRR 1
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116101_12614.0411.6666666666667RepeatNote=LRR 2
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116127_15214.0411.6666666666667RepeatNote=LRR 3
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116153_17814.0411.6666666666667RepeatNote=LRR 4
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116179_20414.0411.6666666666667RepeatNote=LRR 5
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116205_23014.0411.6666666666667RepeatNote=LRR 6
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116231_25614.0411.6666666666667RepeatNote=LRR 7
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116257_28214.0411.6666666666667RepeatNote=LRR 8
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116283_30814.0411.6666666666667RepeatNote=LRR 9
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116309_33414.0411.6666666666667RepeatNote=LRR 10
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116335_36314.0411.6666666666667RepeatNote=LRR 11
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116364_38814.0411.6666666666667RepeatNote=LRR 12
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-116389_41414.0411.6666666666667RepeatNote=LRR 13
HgeneFBXL20chr17:37557614chr20:55020956ENST00000583610-11674_10014.0411.6666666666667RepeatNote=LRR 1
TgeneCASS4chr17:37557614chr20:55020956ENST000003603142711_73153.0787.0DomainSH3
TgeneCASS4chr17:37557614chr20:55020956ENST000003713361611_73153.0787.0DomainSH3
TgeneCASS4chr17:37557614chr20:55020956ENST000004343441511_73153.0350.0DomainSH3


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Fusion Gene Sequence for FBXL20-CASS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000583610_ENST00000360314_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(transcript)=2231nt_BP=296nt
GTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTG
GAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCC
GGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGA
ACGGAGTGACCAAGAGCAGGTTTGAGGCCATCCTCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAGGTGTATG
ACGTGCCTACCCAGCACCGGGGCCCCGTGGTCCTGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAGAAGGCAG
GACTCCATCCCCCAGACAGCCAAGCAAGTGGGCAGGGTGTTCCCCTGATATCAGTGACTACCTTAAGAAGAGGCGGTTACAGCACATTAC
CAAATCCTCAGAAATCGGAATGGATTTATGACACTCCAGTGTCTCCAGGAAAGGCCAGCGTCAGAAACACGCCTCTCACCAGCTTTGCGG
AAGAATCAAGGCCCCACGCTCTCCCCAGTTCCAGCTCCACTTTCTACAATCCTCCAAGTGGCAGATCCAGGTCCCTCACTCCACAACTGA
ATAACAATGTGCCCATGCAGAAAAAACTCAGCCTTCCAGAAATTCCTTCTTATGGCTTTCTTGTACCCAGAGGCACATTTCCTTTGGATG
AAGATGTCAGCTACAAGGTTCCTTCAAGCTTTCTGATTCCCCGAGTGGAACAGCAGAACACCAAGCCCAATATTTATGACATCCCTAAAG
CAACGTCGAGTGTTTCTCAGGCTGGGAAGGAGCTGGAGAAAGCCAAGGAGGTGTCAGAGAATTCCGCGGGCCATAATTCCTCATGGTTCT
CCAGACGGACAACTTCCCCATCTCCTGAACCGGACAGATTATCAGGTTCCAGTTCTGACAGCAGAGCTAGCATCGTTTCCTCGTGCTCCA
CCACATCCACCGACGACTCCTCCAGCTCTTCCTCGGAGGAGTCAGCAAAGGAGCTCTCCTTGGACCTGGATGTGGCCAAGGAGACAGTGA
TGGCTCTGCAGCACAAGGTGGTCAGCTCTGTCGCTGGCCTGATGCTCTTTGTCAGCAGGAAGTGGAGATTCCGAGACTATCTGGAGGCCA
ACATTGATGCAATCCACAGGTCCACTGATCACATAGAAGAATCTGTAAGAGAATTTCTGGATTTTGCCCGAGGAGTCCATGGGACTGCCT
GTAACCTCACTGACAGTAACCTTCAGAACAGAATTCGGGACCAGATGCAGACCATCTCCAACTCCTACCGCATCCTGCTTGAAACAAAGG
AAAGCTTGGATAATCGCAATTGGCCTCTGGAAGTTCTTGTGACTGACAGTGTCCAGAACAGCCCAGATGACCTTGAGAGGTTTGTCATGG
TGGCACGGATGCTTCCAGAAGACATCAAGAGGTTTGCCTCCATTGTCATTGCCAATGGAAGGCTCCTTTTTAAGCGGAACTGTGAAAAGG
AAGAGACTGTGCAGTTGACCCCAAATGCAGAATTTAAGTGTGAAAAATACATCCAGCCTCCCCAAAGAGAAACTGAATCACACCAAAAGA
GTACCCCTTCCACTAAGCAAAGGGAAGATGAACACTCTTCTGAACTATTAAAGAAAAATAGGGCAAATATCTGTGGACAGAATCCTGGCC
CTCTTATACCTCAGCCTTCGAGTCAACAGACTCCTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCGCTCTTCA
AAGCCATCAGCGCATTTCACGGCAGCCTCAGCAGCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTGGGACAGA
AGCTGGTGGACACGCTGTGCATGGAGACCCAGGAGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGCCTGCTCA
AGGACGTAGCGCTGGCCACTAAGAATGCCGTGCTCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAGAAGCTGG

>In-frame_ENST00000583610_ENST00000360314_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(amino acids)=647AA_start in transcript=254_stop in transcript=2197
MRRDVNGVTKSRFEAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASGQGVPLISVTTLRRG
GYSTLPNPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRPHALPSSSSTFYNPPSGRSRSLTPQLNNNVPMQKKLSLPEIPSYGFLVPRG
TFPLDEDVSYKVPSSFLIPRVEQQNTKPNIYDIPKATSSVSQAGKELEKAKEVSENSAGHNSSWFSRRTTSPSPEPDRLSGSSSDSRASI
VSSCSTTSTDDSSSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFRDYLEANIDAIHRSTDHIEESVREFLDFARG
VHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDLERFVMVARMLPEDIKRFASIVIANGRLLFK
RNCEKEETVQLTPNAEFKCEKYIQPPQRETESHQKSTPSTKQREDEHSSELLKKNRANICGQNPGPLIPQPSSQQTPERKPRLSEHCRLY
FGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTYPSPAALGHLQA

--------------------------------------------------------------
>In-frame_ENST00000583610_ENST00000371336_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(transcript)=2791nt_BP=296nt
GTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTG
GAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCC
GGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGA
ACGGAGTGACCAAGAGCAGGTTTGAGGCCATCCTCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAGGTGTATG
ACGTGCCTACCCAGCACCGGGGCCCCGTGGTCCTGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAGAAGGCAG
GACTCCATCCCCCAGACAGCCAAGCAAGTGGGCAGGGTGTTCCCCTGATATCAGTGACTACCTTAAGAAGAGGCGGTTACAGCACATTAC
CAAATCCTCAGAAATCGGAATGGATTTATGACACTCCAGTGTCTCCAGGAAAGGCCAGCGTCAGAAACACGCCTCTCACCAGCTTTGCGG
AAGAATCAAGGCCCCACGCTCTCCCCAGTTCCAGCTCCACTTTCTACAATCCTCCAAGTGGCAGATCCAGGTCCCTCACTCCACAACTGA
ATAACAATGTGCCCATGCAGAAAAAACTCAGCCTTCCAGAAATTCCTTCTTATGGCTTTCTTGTACCCAGAGGCACATTTCCTTTGGATG
AAGATGTCAGCTACAAGGTTCCTTCAAGCTTTCTGATTCCCCGAGTGGAACAGCAGAACACCAAGCCCAATATTTATGACATCCCTAAAG
CAACGTCGAGTGTTTCTCAGGCTGGGAAGGAGCTGGAGAAAGCCAAGGAGGTGTCAGAGAATTCCGCGGGCCATAATTCCTCATGGTTCT
CCAGACGGACAACTTCCCCATCTCCTGAACCGGACAGATTATCAGGTTCCAGTTCTGACAGCAGAGCTAGCATCGTTTCCTCGTGCTCCA
CCACATCCACCGACGACTCCTCCAGCTCTTCCTCGGAGGAGTCAGCAAAGGAGCTCTCCTTGGACCTGGATGTGGCCAAGGAGACAGTGA
TGGCTCTGCAGCACAAGGTGGTCAGCTCTGTCGCTGGCCTGATGCTCTTTGTCAGCAGGAAGTGGAGATTCCGAGACTATCTGGAGGCCA
ACATTGATGCAATCCACAGGTCCACTGATCACATAGAAGAATCTGTAAGAGAATTTCTGGATTTTGCCCGAGGAGTCCATGGGACTGCCT
GTAACCTCACTGACAGTAACCTTCAGAACAGAATTCGGGACCAGATGCAGACCATCTCCAACTCCTACCGCATCCTGCTTGAAACAAAGG
AAAGCTTGGATAATCGCAATTGGCCTCTGGAAGTTCTTGTGACTGACAGTGTCCAGAACAGCCCAGATGACCTTGAGAGGTTTGTCATGG
TGGCACGGATGCTTCCAGAAGACATCAAGAGGTTTGCCTCCATTGTCATTGCCAATGGAAGGCTCCTTTTTAAGCGGAACTGTGAAAAGG
AAGAGACTGTGCAGTTGACCCCAAATGCAGAATTTAAGTGTGAAAAATACATCCAGCCTCCCCAAAGAGAAACTGAATCACACCAAAAGA
GTACCCCTTCCACTAAGCAAAGGGAAGATGAACACTCTTCTGAACTATTAAAGAAAAATAGGGCAAATATCTGTGGACAGAATCCTGGCC
CTCTTATACCTCAGCCTTCGAGTCAACAGACTCCTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCGCTCTTCA
AAGCCATCAGCGCATTTCACGGCAGCCTCAGCAGCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTGGGACAGA
AGCTGGTGGACACGCTGTGCATGGAGACCCAGGAGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGCCTGCTCA
AGGACGTAGCGCTGGCCACTAAGAATGCCGTGCTCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAGAAGCTGG
AGCAACACACGCGGCAGTTCAGAGGGACACTGGGATGAGGACTGTCTACCTCCCTTCCTCCTCTGCTCACCTCTCAGCTTCACACCCACA
ACTTGTGCAACTCTGCCCTATGGGAAAAGCCAGCCGGGGCATACACCAATGAGCTGAAACAGACCTGGTGCCCAAAGCTGGTAGTACCAA
GTGGCTAAGCAACCCCAGGGCATTGACTTACCCCGCAGGGGGTCAGGAAAGAGAGTCAGGTATGAGGTAAAGACCTTGTGAAGTTTAGCA
TATATGGAGTATGCAGTATCAGCTTGAAGTGACTTCGCAGAAATAATATTTTATATTGATTAAATGTGTGCATGTTTTGTTTGTTTTTTG
AGACAAAGTCTCACTCTGTCACACAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTGAAGCAATTCT
CCCGCCTCAGCCTCCAGAGTAGCTGGTACTACAGGTGTGCGCCACCATGCCCAGCTAATTTTTGTATTTTTTTTTAATGAAAGGTCTCAC
ATATTTATTACTGAACCCAGCCAACCAATGCATTCATAACAGATTCAGAAAGAAAAAATATATTCCCAATAAAACATGTACAATTCTCCA

>In-frame_ENST00000583610_ENST00000371336_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(amino acids)=647AA_start in transcript=254_stop in transcript=2197
MRRDVNGVTKSRFEAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASGQGVPLISVTTLRRG
GYSTLPNPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRPHALPSSSSTFYNPPSGRSRSLTPQLNNNVPMQKKLSLPEIPSYGFLVPRG
TFPLDEDVSYKVPSSFLIPRVEQQNTKPNIYDIPKATSSVSQAGKELEKAKEVSENSAGHNSSWFSRRTTSPSPEPDRLSGSSSDSRASI
VSSCSTTSTDDSSSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFRDYLEANIDAIHRSTDHIEESVREFLDFARG
VHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDLERFVMVARMLPEDIKRFASIVIANGRLLFK
RNCEKEETVQLTPNAEFKCEKYIQPPQRETESHQKSTPSTKQREDEHSSELLKKNRANICGQNPGPLIPQPSSQQTPERKPRLSEHCRLY
FGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTYPSPAALGHLQA

--------------------------------------------------------------
>In-frame_ENST00000583610_ENST00000434344_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(transcript)=1479nt_BP=296nt
GTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTG
GAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCC
GGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGA
ACGGAGTGACCAAGAGCAGGTTTGAGGCCATCCTCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAGGTGTATG
ACGTGCCTACCCAGCACCGGGGCCCCGTGGTCCTGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAGAAGGCAG
GACTCCATCCCCCAGACAGCCAAGCAAGTAATCCTGGCCCTCTTATACCTCAGCCTTCGAGTCAACAGACTCCTGAGAGGAAACCCCGCT
TATCTGAACACTGCCGGCTCTACTTTGGGGCGCTCTTCAAAGCCATCAGCGCATTTCACGGCAGCCTCAGCAGCAGCCAGCCCGCGGAGA
TCATCACTCAGAGCAAGCTGGTCATCATGGTGGGACAGAAGCTGGTGGACACGCTGTGCATGGAGACCCAGGAGAGGGACGTGCGCAACG
AGATCCTCCGTGGCAGCAGTCACCTCTGCAGCCTGCTCAAGGACGTAGCGCTGGCCACTAAGAATGCCGTGCTCACGTACCCCAGCCCTG
CCGCGCTGGGGCACCTCCAGGCGGAGGCTGAGAAGCTGGAGCAACACACGCGGCAGTTCAGAGGGACACTGGGATGAGGACTGTCTACCT
CCCTTCCTCCTCTGCTCACCTCTCAGCTTCACACCCACAACTTGTGCAACTCTGCCCTATGGGAAAAGCCAGCCGGGGCATACACCAATG
AGCTGAAACAGACCTGGTGCCCAAAGCTGGTAGTACCAAGTGGCTAAGCAACCCCAGGGCATTGACTTACCCCGCAGGGGGTCAGGAAAG
AGAGTCAGGTATGAGGTAAAGACCTTGTGAAGTTTAGCATATATGGAGTATGCAGTATCAGCTTGAAGTGACTTCGCAGAAATAATATTT
TATATTGATTAAATGTGTGCATGTTTTGTTTGTTTTTTGAGACAAAGTCTCACTCTGTCACACAGGCTGGAGTGCAGTGGCGCGATCTCA
GCTCACTGCAACCTCCGCCTTCTGGGTTGAAGCAATTCTCCCGCCTCAGCCTCCAGAGTAGCTGGTACTACAGGTGTGCGCCACCATGCC
CAGCTAATTTTTGTATTTTTTTTTAATGAAAGGTCTCACATATTTATTACTGAACCCAGCCAACCAATGCATTCATAACAGATTCAGAAA

>In-frame_ENST00000583610_ENST00000434344_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(amino acids)=210AA_start in transcript=254_stop in transcript=886
MRRDVNGVTKSRFEAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASNPGPLIPQPSSQQTP
ERKPRLSEHCRLYFGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVL

--------------------------------------------------------------
>In-frame_ENST00000394294_ENST00000360314_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(transcript)=2198nt_BP=263nt
GAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTC
CCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCC
GCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGAACGGAGTGACCAAGAGCAGGTTTGAGGCCATCC
TCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAGGTGTATGACGTGCCTACCCAGCACCGGGGCCCCGTGGTCC
TGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAGAAGGCAGGACTCCATCCCCCAGACAGCCAAGCAAGTGGGC
AGGGTGTTCCCCTGATATCAGTGACTACCTTAAGAAGAGGCGGTTACAGCACATTACCAAATCCTCAGAAATCGGAATGGATTTATGACA
CTCCAGTGTCTCCAGGAAAGGCCAGCGTCAGAAACACGCCTCTCACCAGCTTTGCGGAAGAATCAAGGCCCCACGCTCTCCCCAGTTCCA
GCTCCACTTTCTACAATCCTCCAAGTGGCAGATCCAGGTCCCTCACTCCACAACTGAATAACAATGTGCCCATGCAGAAAAAACTCAGCC
TTCCAGAAATTCCTTCTTATGGCTTTCTTGTACCCAGAGGCACATTTCCTTTGGATGAAGATGTCAGCTACAAGGTTCCTTCAAGCTTTC
TGATTCCCCGAGTGGAACAGCAGAACACCAAGCCCAATATTTATGACATCCCTAAAGCAACGTCGAGTGTTTCTCAGGCTGGGAAGGAGC
TGGAGAAAGCCAAGGAGGTGTCAGAGAATTCCGCGGGCCATAATTCCTCATGGTTCTCCAGACGGACAACTTCCCCATCTCCTGAACCGG
ACAGATTATCAGGTTCCAGTTCTGACAGCAGAGCTAGCATCGTTTCCTCGTGCTCCACCACATCCACCGACGACTCCTCCAGCTCTTCCT
CGGAGGAGTCAGCAAAGGAGCTCTCCTTGGACCTGGATGTGGCCAAGGAGACAGTGATGGCTCTGCAGCACAAGGTGGTCAGCTCTGTCG
CTGGCCTGATGCTCTTTGTCAGCAGGAAGTGGAGATTCCGAGACTATCTGGAGGCCAACATTGATGCAATCCACAGGTCCACTGATCACA
TAGAAGAATCTGTAAGAGAATTTCTGGATTTTGCCCGAGGAGTCCATGGGACTGCCTGTAACCTCACTGACAGTAACCTTCAGAACAGAA
TTCGGGACCAGATGCAGACCATCTCCAACTCCTACCGCATCCTGCTTGAAACAAAGGAAAGCTTGGATAATCGCAATTGGCCTCTGGAAG
TTCTTGTGACTGACAGTGTCCAGAACAGCCCAGATGACCTTGAGAGGTTTGTCATGGTGGCACGGATGCTTCCAGAAGACATCAAGAGGT
TTGCCTCCATTGTCATTGCCAATGGAAGGCTCCTTTTTAAGCGGAACTGTGAAAAGGAAGAGACTGTGCAGTTGACCCCAAATGCAGAAT
TTAAGTGTGAAAAATACATCCAGCCTCCCCAAAGAGAAACTGAATCACACCAAAAGAGTACCCCTTCCACTAAGCAAAGGGAAGATGAAC
ACTCTTCTGAACTATTAAAGAAAAATAGGGCAAATATCTGTGGACAGAATCCTGGCCCTCTTATACCTCAGCCTTCGAGTCAACAGACTC
CTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCGCTCTTCAAAGCCATCAGCGCATTTCACGGCAGCCTCAGCA
GCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTGGGACAGAAGCTGGTGGACACGCTGTGCATGGAGACCCAGG
AGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGCCTGCTCAAGGACGTAGCGCTGGCCACTAAGAATGCCGTGC
TCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAGAAGCTGGAGCAACACACGCGGCAGTTCAGAGGGACACTGG

>In-frame_ENST00000394294_ENST00000360314_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(amino acids)=647AA_start in transcript=221_stop in transcript=2164
MRRDVNGVTKSRFEAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASGQGVPLISVTTLRRG
GYSTLPNPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRPHALPSSSSTFYNPPSGRSRSLTPQLNNNVPMQKKLSLPEIPSYGFLVPRG
TFPLDEDVSYKVPSSFLIPRVEQQNTKPNIYDIPKATSSVSQAGKELEKAKEVSENSAGHNSSWFSRRTTSPSPEPDRLSGSSSDSRASI
VSSCSTTSTDDSSSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFRDYLEANIDAIHRSTDHIEESVREFLDFARG
VHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDLERFVMVARMLPEDIKRFASIVIANGRLLFK
RNCEKEETVQLTPNAEFKCEKYIQPPQRETESHQKSTPSTKQREDEHSSELLKKNRANICGQNPGPLIPQPSSQQTPERKPRLSEHCRLY
FGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTYPSPAALGHLQA

--------------------------------------------------------------
>In-frame_ENST00000394294_ENST00000371336_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(transcript)=2758nt_BP=263nt
GAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTC
CCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCC
GCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGAACGGAGTGACCAAGAGCAGGTTTGAGGCCATCC
TCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAGGTGTATGACGTGCCTACCCAGCACCGGGGCCCCGTGGTCC
TGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAGAAGGCAGGACTCCATCCCCCAGACAGCCAAGCAAGTGGGC
AGGGTGTTCCCCTGATATCAGTGACTACCTTAAGAAGAGGCGGTTACAGCACATTACCAAATCCTCAGAAATCGGAATGGATTTATGACA
CTCCAGTGTCTCCAGGAAAGGCCAGCGTCAGAAACACGCCTCTCACCAGCTTTGCGGAAGAATCAAGGCCCCACGCTCTCCCCAGTTCCA
GCTCCACTTTCTACAATCCTCCAAGTGGCAGATCCAGGTCCCTCACTCCACAACTGAATAACAATGTGCCCATGCAGAAAAAACTCAGCC
TTCCAGAAATTCCTTCTTATGGCTTTCTTGTACCCAGAGGCACATTTCCTTTGGATGAAGATGTCAGCTACAAGGTTCCTTCAAGCTTTC
TGATTCCCCGAGTGGAACAGCAGAACACCAAGCCCAATATTTATGACATCCCTAAAGCAACGTCGAGTGTTTCTCAGGCTGGGAAGGAGC
TGGAGAAAGCCAAGGAGGTGTCAGAGAATTCCGCGGGCCATAATTCCTCATGGTTCTCCAGACGGACAACTTCCCCATCTCCTGAACCGG
ACAGATTATCAGGTTCCAGTTCTGACAGCAGAGCTAGCATCGTTTCCTCGTGCTCCACCACATCCACCGACGACTCCTCCAGCTCTTCCT
CGGAGGAGTCAGCAAAGGAGCTCTCCTTGGACCTGGATGTGGCCAAGGAGACAGTGATGGCTCTGCAGCACAAGGTGGTCAGCTCTGTCG
CTGGCCTGATGCTCTTTGTCAGCAGGAAGTGGAGATTCCGAGACTATCTGGAGGCCAACATTGATGCAATCCACAGGTCCACTGATCACA
TAGAAGAATCTGTAAGAGAATTTCTGGATTTTGCCCGAGGAGTCCATGGGACTGCCTGTAACCTCACTGACAGTAACCTTCAGAACAGAA
TTCGGGACCAGATGCAGACCATCTCCAACTCCTACCGCATCCTGCTTGAAACAAAGGAAAGCTTGGATAATCGCAATTGGCCTCTGGAAG
TTCTTGTGACTGACAGTGTCCAGAACAGCCCAGATGACCTTGAGAGGTTTGTCATGGTGGCACGGATGCTTCCAGAAGACATCAAGAGGT
TTGCCTCCATTGTCATTGCCAATGGAAGGCTCCTTTTTAAGCGGAACTGTGAAAAGGAAGAGACTGTGCAGTTGACCCCAAATGCAGAAT
TTAAGTGTGAAAAATACATCCAGCCTCCCCAAAGAGAAACTGAATCACACCAAAAGAGTACCCCTTCCACTAAGCAAAGGGAAGATGAAC
ACTCTTCTGAACTATTAAAGAAAAATAGGGCAAATATCTGTGGACAGAATCCTGGCCCTCTTATACCTCAGCCTTCGAGTCAACAGACTC
CTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCGCTCTTCAAAGCCATCAGCGCATTTCACGGCAGCCTCAGCA
GCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTGGGACAGAAGCTGGTGGACACGCTGTGCATGGAGACCCAGG
AGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGCCTGCTCAAGGACGTAGCGCTGGCCACTAAGAATGCCGTGC
TCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAGAAGCTGGAGCAACACACGCGGCAGTTCAGAGGGACACTGG
GATGAGGACTGTCTACCTCCCTTCCTCCTCTGCTCACCTCTCAGCTTCACACCCACAACTTGTGCAACTCTGCCCTATGGGAAAAGCCAG
CCGGGGCATACACCAATGAGCTGAAACAGACCTGGTGCCCAAAGCTGGTAGTACCAAGTGGCTAAGCAACCCCAGGGCATTGACTTACCC
CGCAGGGGGTCAGGAAAGAGAGTCAGGTATGAGGTAAAGACCTTGTGAAGTTTAGCATATATGGAGTATGCAGTATCAGCTTGAAGTGAC
TTCGCAGAAATAATATTTTATATTGATTAAATGTGTGCATGTTTTGTTTGTTTTTTGAGACAAAGTCTCACTCTGTCACACAGGCTGGAG
TGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTGAAGCAATTCTCCCGCCTCAGCCTCCAGAGTAGCTGGTACTACA
GGTGTGCGCCACCATGCCCAGCTAATTTTTGTATTTTTTTTTAATGAAAGGTCTCACATATTTATTACTGAACCCAGCCAACCAATGCAT

>In-frame_ENST00000394294_ENST00000371336_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(amino acids)=647AA_start in transcript=221_stop in transcript=2164
MRRDVNGVTKSRFEAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASGQGVPLISVTTLRRG
GYSTLPNPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRPHALPSSSSTFYNPPSGRSRSLTPQLNNNVPMQKKLSLPEIPSYGFLVPRG
TFPLDEDVSYKVPSSFLIPRVEQQNTKPNIYDIPKATSSVSQAGKELEKAKEVSENSAGHNSSWFSRRTTSPSPEPDRLSGSSSDSRASI
VSSCSTTSTDDSSSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFRDYLEANIDAIHRSTDHIEESVREFLDFARG
VHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDLERFVMVARMLPEDIKRFASIVIANGRLLFK
RNCEKEETVQLTPNAEFKCEKYIQPPQRETESHQKSTPSTKQREDEHSSELLKKNRANICGQNPGPLIPQPSSQQTPERKPRLSEHCRLY
FGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTYPSPAALGHLQA

--------------------------------------------------------------
>In-frame_ENST00000394294_ENST00000434344_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(transcript)=1446nt_BP=263nt
GAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTC
CCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCC
GCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGAACGGAGTGACCAAGAGCAGGTTTGAGGCCATCC
TCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAGGTGTATGACGTGCCTACCCAGCACCGGGGCCCCGTGGTCC
TGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAGAAGGCAGGACTCCATCCCCCAGACAGCCAAGCAAGTAATC
CTGGCCCTCTTATACCTCAGCCTTCGAGTCAACAGACTCCTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCGC
TCTTCAAAGCCATCAGCGCATTTCACGGCAGCCTCAGCAGCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTGG
GACAGAAGCTGGTGGACACGCTGTGCATGGAGACCCAGGAGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGCC
TGCTCAAGGACGTAGCGCTGGCCACTAAGAATGCCGTGCTCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAGA
AGCTGGAGCAACACACGCGGCAGTTCAGAGGGACACTGGGATGAGGACTGTCTACCTCCCTTCCTCCTCTGCTCACCTCTCAGCTTCACA
CCCACAACTTGTGCAACTCTGCCCTATGGGAAAAGCCAGCCGGGGCATACACCAATGAGCTGAAACAGACCTGGTGCCCAAAGCTGGTAG
TACCAAGTGGCTAAGCAACCCCAGGGCATTGACTTACCCCGCAGGGGGTCAGGAAAGAGAGTCAGGTATGAGGTAAAGACCTTGTGAAGT
TTAGCATATATGGAGTATGCAGTATCAGCTTGAAGTGACTTCGCAGAAATAATATTTTATATTGATTAAATGTGTGCATGTTTTGTTTGT
TTTTTGAGACAAAGTCTCACTCTGTCACACAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTGAAGC
AATTCTCCCGCCTCAGCCTCCAGAGTAGCTGGTACTACAGGTGTGCGCCACCATGCCCAGCTAATTTTTGTATTTTTTTTTAATGAAAGG
TCTCACATATTTATTACTGAACCCAGCCAACCAATGCATTCATAACAGATTCAGAAAGAAAAAATATATTCCCAATAAAACATGTACAAT

>In-frame_ENST00000394294_ENST00000434344_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(amino acids)=210AA_start in transcript=221_stop in transcript=853
MRRDVNGVTKSRFEAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASNPGPLIPQPSSQQTP
ERKPRLSEHCRLYFGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVL

--------------------------------------------------------------
>In-frame_ENST00000264658_ENST00000360314_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(transcript)=2238nt_BP=303nt
GGGGAGTGTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGA
GGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGG
AACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGG
GACGTGAACGGAGTGACCAAGAGCAGGTTTGAGGCCATCCTCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAG
GTGTATGACGTGCCTACCCAGCACCGGGGCCCCGTGGTCCTGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAG
AAGGCAGGACTCCATCCCCCAGACAGCCAAGCAAGTGGGCAGGGTGTTCCCCTGATATCAGTGACTACCTTAAGAAGAGGCGGTTACAGC
ACATTACCAAATCCTCAGAAATCGGAATGGATTTATGACACTCCAGTGTCTCCAGGAAAGGCCAGCGTCAGAAACACGCCTCTCACCAGC
TTTGCGGAAGAATCAAGGCCCCACGCTCTCCCCAGTTCCAGCTCCACTTTCTACAATCCTCCAAGTGGCAGATCCAGGTCCCTCACTCCA
CAACTGAATAACAATGTGCCCATGCAGAAAAAACTCAGCCTTCCAGAAATTCCTTCTTATGGCTTTCTTGTACCCAGAGGCACATTTCCT
TTGGATGAAGATGTCAGCTACAAGGTTCCTTCAAGCTTTCTGATTCCCCGAGTGGAACAGCAGAACACCAAGCCCAATATTTATGACATC
CCTAAAGCAACGTCGAGTGTTTCTCAGGCTGGGAAGGAGCTGGAGAAAGCCAAGGAGGTGTCAGAGAATTCCGCGGGCCATAATTCCTCA
TGGTTCTCCAGACGGACAACTTCCCCATCTCCTGAACCGGACAGATTATCAGGTTCCAGTTCTGACAGCAGAGCTAGCATCGTTTCCTCG
TGCTCCACCACATCCACCGACGACTCCTCCAGCTCTTCCTCGGAGGAGTCAGCAAAGGAGCTCTCCTTGGACCTGGATGTGGCCAAGGAG
ACAGTGATGGCTCTGCAGCACAAGGTGGTCAGCTCTGTCGCTGGCCTGATGCTCTTTGTCAGCAGGAAGTGGAGATTCCGAGACTATCTG
GAGGCCAACATTGATGCAATCCACAGGTCCACTGATCACATAGAAGAATCTGTAAGAGAATTTCTGGATTTTGCCCGAGGAGTCCATGGG
ACTGCCTGTAACCTCACTGACAGTAACCTTCAGAACAGAATTCGGGACCAGATGCAGACCATCTCCAACTCCTACCGCATCCTGCTTGAA
ACAAAGGAAAGCTTGGATAATCGCAATTGGCCTCTGGAAGTTCTTGTGACTGACAGTGTCCAGAACAGCCCAGATGACCTTGAGAGGTTT
GTCATGGTGGCACGGATGCTTCCAGAAGACATCAAGAGGTTTGCCTCCATTGTCATTGCCAATGGAAGGCTCCTTTTTAAGCGGAACTGT
GAAAAGGAAGAGACTGTGCAGTTGACCCCAAATGCAGAATTTAAGTGTGAAAAATACATCCAGCCTCCCCAAAGAGAAACTGAATCACAC
CAAAAGAGTACCCCTTCCACTAAGCAAAGGGAAGATGAACACTCTTCTGAACTATTAAAGAAAAATAGGGCAAATATCTGTGGACAGAAT
CCTGGCCCTCTTATACCTCAGCCTTCGAGTCAACAGACTCCTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCG
CTCTTCAAAGCCATCAGCGCATTTCACGGCAGCCTCAGCAGCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTG
GGACAGAAGCTGGTGGACACGCTGTGCATGGAGACCCAGGAGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGC
CTGCTCAAGGACGTAGCGCTGGCCACTAAGAATGCCGTGCTCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAG

>In-frame_ENST00000264658_ENST00000360314_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(amino acids)=647AA_start in transcript=261_stop in transcript=2204
MRRDVNGVTKSRFEAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASGQGVPLISVTTLRRG
GYSTLPNPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRPHALPSSSSTFYNPPSGRSRSLTPQLNNNVPMQKKLSLPEIPSYGFLVPRG
TFPLDEDVSYKVPSSFLIPRVEQQNTKPNIYDIPKATSSVSQAGKELEKAKEVSENSAGHNSSWFSRRTTSPSPEPDRLSGSSSDSRASI
VSSCSTTSTDDSSSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFRDYLEANIDAIHRSTDHIEESVREFLDFARG
VHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDLERFVMVARMLPEDIKRFASIVIANGRLLFK
RNCEKEETVQLTPNAEFKCEKYIQPPQRETESHQKSTPSTKQREDEHSSELLKKNRANICGQNPGPLIPQPSSQQTPERKPRLSEHCRLY
FGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTYPSPAALGHLQA

--------------------------------------------------------------
>In-frame_ENST00000264658_ENST00000371336_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(transcript)=2798nt_BP=303nt
GGGGAGTGTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGA
GGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGG
AACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGG
GACGTGAACGGAGTGACCAAGAGCAGGTTTGAGGCCATCCTCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAG
GTGTATGACGTGCCTACCCAGCACCGGGGCCCCGTGGTCCTGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAG
AAGGCAGGACTCCATCCCCCAGACAGCCAAGCAAGTGGGCAGGGTGTTCCCCTGATATCAGTGACTACCTTAAGAAGAGGCGGTTACAGC
ACATTACCAAATCCTCAGAAATCGGAATGGATTTATGACACTCCAGTGTCTCCAGGAAAGGCCAGCGTCAGAAACACGCCTCTCACCAGC
TTTGCGGAAGAATCAAGGCCCCACGCTCTCCCCAGTTCCAGCTCCACTTTCTACAATCCTCCAAGTGGCAGATCCAGGTCCCTCACTCCA
CAACTGAATAACAATGTGCCCATGCAGAAAAAACTCAGCCTTCCAGAAATTCCTTCTTATGGCTTTCTTGTACCCAGAGGCACATTTCCT
TTGGATGAAGATGTCAGCTACAAGGTTCCTTCAAGCTTTCTGATTCCCCGAGTGGAACAGCAGAACACCAAGCCCAATATTTATGACATC
CCTAAAGCAACGTCGAGTGTTTCTCAGGCTGGGAAGGAGCTGGAGAAAGCCAAGGAGGTGTCAGAGAATTCCGCGGGCCATAATTCCTCA
TGGTTCTCCAGACGGACAACTTCCCCATCTCCTGAACCGGACAGATTATCAGGTTCCAGTTCTGACAGCAGAGCTAGCATCGTTTCCTCG
TGCTCCACCACATCCACCGACGACTCCTCCAGCTCTTCCTCGGAGGAGTCAGCAAAGGAGCTCTCCTTGGACCTGGATGTGGCCAAGGAG
ACAGTGATGGCTCTGCAGCACAAGGTGGTCAGCTCTGTCGCTGGCCTGATGCTCTTTGTCAGCAGGAAGTGGAGATTCCGAGACTATCTG
GAGGCCAACATTGATGCAATCCACAGGTCCACTGATCACATAGAAGAATCTGTAAGAGAATTTCTGGATTTTGCCCGAGGAGTCCATGGG
ACTGCCTGTAACCTCACTGACAGTAACCTTCAGAACAGAATTCGGGACCAGATGCAGACCATCTCCAACTCCTACCGCATCCTGCTTGAA
ACAAAGGAAAGCTTGGATAATCGCAATTGGCCTCTGGAAGTTCTTGTGACTGACAGTGTCCAGAACAGCCCAGATGACCTTGAGAGGTTT
GTCATGGTGGCACGGATGCTTCCAGAAGACATCAAGAGGTTTGCCTCCATTGTCATTGCCAATGGAAGGCTCCTTTTTAAGCGGAACTGT
GAAAAGGAAGAGACTGTGCAGTTGACCCCAAATGCAGAATTTAAGTGTGAAAAATACATCCAGCCTCCCCAAAGAGAAACTGAATCACAC
CAAAAGAGTACCCCTTCCACTAAGCAAAGGGAAGATGAACACTCTTCTGAACTATTAAAGAAAAATAGGGCAAATATCTGTGGACAGAAT
CCTGGCCCTCTTATACCTCAGCCTTCGAGTCAACAGACTCCTGAGAGGAAACCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCG
CTCTTCAAAGCCATCAGCGCATTTCACGGCAGCCTCAGCAGCAGCCAGCCCGCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTG
GGACAGAAGCTGGTGGACACGCTGTGCATGGAGACCCAGGAGAGGGACGTGCGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGC
CTGCTCAAGGACGTAGCGCTGGCCACTAAGAATGCCGTGCTCACGTACCCCAGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAG
AAGCTGGAGCAACACACGCGGCAGTTCAGAGGGACACTGGGATGAGGACTGTCTACCTCCCTTCCTCCTCTGCTCACCTCTCAGCTTCAC
ACCCACAACTTGTGCAACTCTGCCCTATGGGAAAAGCCAGCCGGGGCATACACCAATGAGCTGAAACAGACCTGGTGCCCAAAGCTGGTA
GTACCAAGTGGCTAAGCAACCCCAGGGCATTGACTTACCCCGCAGGGGGTCAGGAAAGAGAGTCAGGTATGAGGTAAAGACCTTGTGAAG
TTTAGCATATATGGAGTATGCAGTATCAGCTTGAAGTGACTTCGCAGAAATAATATTTTATATTGATTAAATGTGTGCATGTTTTGTTTG
TTTTTTGAGACAAAGTCTCACTCTGTCACACAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTGAAG
CAATTCTCCCGCCTCAGCCTCCAGAGTAGCTGGTACTACAGGTGTGCGCCACCATGCCCAGCTAATTTTTGTATTTTTTTTTAATGAAAG
GTCTCACATATTTATTACTGAACCCAGCCAACCAATGCATTCATAACAGATTCAGAAAGAAAAAATATATTCCCAATAAAACATGTACAA

>In-frame_ENST00000264658_ENST00000371336_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(amino acids)=647AA_start in transcript=261_stop in transcript=2204
MRRDVNGVTKSRFEAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASGQGVPLISVTTLRRG
GYSTLPNPQKSEWIYDTPVSPGKASVRNTPLTSFAEESRPHALPSSSSTFYNPPSGRSRSLTPQLNNNVPMQKKLSLPEIPSYGFLVPRG
TFPLDEDVSYKVPSSFLIPRVEQQNTKPNIYDIPKATSSVSQAGKELEKAKEVSENSAGHNSSWFSRRTTSPSPEPDRLSGSSSDSRASI
VSSCSTTSTDDSSSSSSEESAKELSLDLDVAKETVMALQHKVVSSVAGLMLFVSRKWRFRDYLEANIDAIHRSTDHIEESVREFLDFARG
VHGTACNLTDSNLQNRIRDQMQTISNSYRILLETKESLDNRNWPLEVLVTDSVQNSPDDLERFVMVARMLPEDIKRFASIVIANGRLLFK
RNCEKEETVQLTPNAEFKCEKYIQPPQRETESHQKSTPSTKQREDEHSSELLKKNRANICGQNPGPLIPQPSSQQTPERKPRLSEHCRLY
FGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVLTYPSPAALGHLQA

--------------------------------------------------------------
>In-frame_ENST00000264658_ENST00000434344_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(transcript)=1486nt_BP=303nt
GGGGAGTGTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGA
GGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGG
AACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGG
GACGTGAACGGAGTGACCAAGAGCAGGTTTGAGGCCATCCTCACGCTTCCCAGACCTGTCCGGGCCTCACTGCCGACTCTGCCTTCCCAG
GTGTATGACGTGCCTACCCAGCACCGGGGCCCCGTGGTCCTGAAGGAGCCAGAGAAGCAGCAGTTATATGACATACCAGCCAGCCCCAAG
AAGGCAGGACTCCATCCCCCAGACAGCCAAGCAAGTAATCCTGGCCCTCTTATACCTCAGCCTTCGAGTCAACAGACTCCTGAGAGGAAA
CCCCGCTTATCTGAACACTGCCGGCTCTACTTTGGGGCGCTCTTCAAAGCCATCAGCGCATTTCACGGCAGCCTCAGCAGCAGCCAGCCC
GCGGAGATCATCACTCAGAGCAAGCTGGTCATCATGGTGGGACAGAAGCTGGTGGACACGCTGTGCATGGAGACCCAGGAGAGGGACGTG
CGCAACGAGATCCTCCGTGGCAGCAGTCACCTCTGCAGCCTGCTCAAGGACGTAGCGCTGGCCACTAAGAATGCCGTGCTCACGTACCCC
AGCCCTGCCGCGCTGGGGCACCTCCAGGCGGAGGCTGAGAAGCTGGAGCAACACACGCGGCAGTTCAGAGGGACACTGGGATGAGGACTG
TCTACCTCCCTTCCTCCTCTGCTCACCTCTCAGCTTCACACCCACAACTTGTGCAACTCTGCCCTATGGGAAAAGCCAGCCGGGGCATAC
ACCAATGAGCTGAAACAGACCTGGTGCCCAAAGCTGGTAGTACCAAGTGGCTAAGCAACCCCAGGGCATTGACTTACCCCGCAGGGGGTC
AGGAAAGAGAGTCAGGTATGAGGTAAAGACCTTGTGAAGTTTAGCATATATGGAGTATGCAGTATCAGCTTGAAGTGACTTCGCAGAAAT
AATATTTTATATTGATTAAATGTGTGCATGTTTTGTTTGTTTTTTGAGACAAAGTCTCACTCTGTCACACAGGCTGGAGTGCAGTGGCGC
GATCTCAGCTCACTGCAACCTCCGCCTTCTGGGTTGAAGCAATTCTCCCGCCTCAGCCTCCAGAGTAGCTGGTACTACAGGTGTGCGCCA
CCATGCCCAGCTAATTTTTGTATTTTTTTTTAATGAAAGGTCTCACATATTTATTACTGAACCCAGCCAACCAATGCATTCATAACAGAT

>In-frame_ENST00000264658_ENST00000434344_TCGA-AN-A0FV-01A_FBXL20_chr17_37557614_-_CASS4_chr20_55020956_length(amino acids)=210AA_start in transcript=261_stop in transcript=893
MRRDVNGVTKSRFEAILTLPRPVRASLPTLPSQVYDVPTQHRGPVVLKEPEKQQLYDIPASPKKAGLHPPDSQASNPGPLIPQPSSQQTP
ERKPRLSEHCRLYFGALFKAISAFHGSLSSSQPAEIITQSKLVIMVGQKLVDTLCMETQERDVRNEILRGSSHLCSLLKDVALATKNAVL

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Fusion Gene PPI Analysis for FBXL20-CASS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXL20-CASS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXL20-CASS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCASS4C0002395Alzheimer's Disease1CTD_human
TgeneCASS4C0011265Presenile dementia1CTD_human
TgeneCASS4C0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneCASS4C0494463Alzheimer Disease, Late Onset1CTD_human
TgeneCASS4C0546126Acute Confusional Senile Dementia1CTD_human
TgeneCASS4C0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneCASS4C0750901Alzheimer Disease, Early Onset1CTD_human