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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FBXW11-RAC1 (FusionGDB2 ID:29804)

Fusion Gene Summary for FBXW11-RAC1

Fusion gene summary

Fusion gene information	Fusion gene name: FBXW11-RAC1
	Fusion gene ID: 29804
		Hgene	Tgene
	Gene symbol	FBXW11	RAC1
	Gene ID	23291	6035
	Gene name	F-box and WD repeat domain containing 11	ribonuclease A family member 1, pancreatic
	Synonyms	BTRC2\|BTRCP2\|FBW1B\|FBXW1B\|Fbw11\|Hos	RAC1\|RIB1\|RNS1
	Cytomap	5q35.1	14q11.2
	Type of gene	protein-coding	protein-coding
	Description	F-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homolog	ribonuclease pancreaticHP-RNaseRIB-1RNase 1RNase ARNase upI-1ribonuclease 1ribonuclease A C1ribonuclease, RNase A family, 1 (pancreatic)
	Modification date	20200329	20200313
	UniProtAcc	Q9UKB1	.
	Ensembl transtripts involved in fusion gene	ENST00000296933, ENST00000265094, ENST00000393802, ENST00000425623, ENST00000522891,	ENST00000348035, ENST00000356142, ENST00000488373,
Fusion gene scores	* DoF score	13 X 6 X 9=702	17 X 10 X 5=850
	# samples	13	18
	** MAII score	log2(13/702*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/850*10)=-2.23946593469539 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FBXW11 [Title/Abstract] AND RAC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FBXW11(171433462)-RAC1(6439757), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FBXW11	GO:0000209	protein polyubiquitination	20347421
Hgene	FBXW11	GO:0016567	protein ubiquitination	16885022
Hgene	FBXW11	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	20347421
Hgene	FBXW11	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	20347421
Tgene	RAC1	GO:0051607	defense response to virus	9826755
Tgene	RAC1	GO:0090501	RNA phosphodiester bond hydrolysis	9826755

Fusion gene breakpoints across FBXW11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-FP-8209-01A	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+

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Fusion Gene ORF analysis for FBXW11-RAC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000296933	ENST00000348035	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
In-frame	ENST00000296933	ENST00000356142	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
5CDS-3UTR	ENST00000296933	ENST00000488373	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
In-frame	ENST00000265094	ENST00000348035	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
In-frame	ENST00000265094	ENST00000356142	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
5CDS-3UTR	ENST00000265094	ENST00000488373	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
In-frame	ENST00000393802	ENST00000348035	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
In-frame	ENST00000393802	ENST00000356142	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
5CDS-3UTR	ENST00000393802	ENST00000488373	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
intron-3CDS	ENST00000425623	ENST00000348035	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
intron-3CDS	ENST00000425623	ENST00000356142	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
intron-3UTR	ENST00000425623	ENST00000488373	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
intron-3CDS	ENST00000522891	ENST00000348035	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
intron-3CDS	ENST00000522891	ENST00000356142	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+
intron-3UTR	ENST00000522891	ENST00000488373	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000296933	FBXW11	chr5	171433462	-	ENST00000348035	RAC1	chr7	6439757	+	2301	416	290	769	159
ENST00000296933	FBXW11	chr5	171433462	-	ENST00000356142	RAC1	chr7	6439757	+	844	416	600	100	166
ENST00000265094	FBXW11	chr5	171433462	-	ENST00000348035	RAC1	chr7	6439757	+	2068	183	57	536	159
ENST00000265094	FBXW11	chr5	171433462	-	ENST00000356142	RAC1	chr7	6439757	+	611	183	57	536	159
ENST00000393802	FBXW11	chr5	171433462	-	ENST00000348035	RAC1	chr7	6439757	+	2078	193	67	546	159
ENST00000393802	FBXW11	chr5	171433462	-	ENST00000356142	RAC1	chr7	6439757	+	621	193	67	546	159

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000296933	ENST00000348035	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+	0.022785144	0.9772149
ENST00000296933	ENST00000356142	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+	0.02767181	0.9723282
ENST00000265094	ENST00000348035	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+	0.007416593	0.9925834
ENST00000265094	ENST00000356142	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+	0.012730984	0.98726904
ENST00000393802	ENST00000348035	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+	0.007372871	0.9926271
ENST00000393802	ENST00000356142	FBXW11	chr5	171433462	-	RAC1	chr7	6439757	+	0.015093767	0.98490626

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Fusion Genomic Features for FBXW11-RAC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FBXW11	chr5	171433461	-	RAC1	chr7	6439756	+	8.57E-06	0.9999914
FBXW11	chr5	171433461	-	RAC1	chr7	6439756	+	8.57E-06	0.9999914

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FBXW11-RAC1

Go to
FGviewer for the breakpoints of chr5:171433462-chr7:6439757
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FBXW11 Q9UKB1	.
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262). {ECO:0000269\|PubMed:10321728, ECO:0000269\|PubMed:10437795, ECO:0000269\|PubMed:10644755, ECO:0000269\|PubMed:10648623, ECO:0000269\|PubMed:14532120, ECO:0000269\|PubMed:14603323, ECO:0000269\|PubMed:15917222, ECO:0000269\|PubMed:18575781, ECO:0000269\|PubMed:19966869, ECO:0000269\|PubMed:20347421, ECO:0000269\|PubMed:25503564, ECO:0000269\|PubMed:29420262}.; FUNCTION: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269\|PubMed:19730691}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000348035

116_118

75.0

193.0

Nucleotide binding

GTP

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000348035

159_160

75.0

193.0

Nucleotide binding

GTP

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000356142

116_118

94.0

212.0

Nucleotide binding

GTP

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000356142

159_160

94.0

212.0

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000265094

129_167

15.0

1360.3333333333333

Domain

F-box

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000296933

129_167

15.0

1283.6666666666667

Domain

F-box

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000393802

129_167

15.0

592.0

Domain

F-box

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000265094

67_116

15.0

1360.3333333333333

Region

Homodimerization domain D

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000296933

67_116

15.0

1283.6666666666667

Region

Homodimerization domain D

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000393802

67_116

15.0

592.0

Region

Homodimerization domain D

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000265094

238_275

15.0

1360.3333333333333

Repeat

Note=WD 1

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000265094

278_315

15.0

1360.3333333333333

Repeat

Note=WD 2

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000265094

318_355

15.0

1360.3333333333333

Repeat

Note=WD 3

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000265094

361_398

15.0

1360.3333333333333

Repeat

Note=WD 4

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000265094

401_440

15.0

1360.3333333333333

Repeat

Note=WD 5

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000265094

442_478

15.0

1360.3333333333333

Repeat

Note=WD 6

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000265094

490_527

15.0

1360.3333333333333

Repeat

Note=WD 7

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000296933

238_275

15.0

1283.6666666666667

Repeat

Note=WD 1

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000296933

278_315

15.0

1283.6666666666667

Repeat

Note=WD 2

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000296933

318_355

15.0

1283.6666666666667

Repeat

Note=WD 3

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000296933

361_398

15.0

1283.6666666666667

Repeat

Note=WD 4

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000296933

401_440

15.0

1283.6666666666667

Repeat

Note=WD 5

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000296933

442_478

15.0

1283.6666666666667

Repeat

Note=WD 6

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000296933

490_527

15.0

1283.6666666666667

Repeat

Note=WD 7

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000393802

238_275

15.0

592.0

Repeat

Note=WD 1

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000393802

278_315

15.0

592.0

Repeat

Note=WD 2

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000393802

318_355

15.0

592.0

Repeat

Note=WD 3

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000393802

361_398

15.0

592.0

Repeat

Note=WD 4

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000393802

401_440

15.0

592.0

Repeat

Note=WD 5

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000393802

442_478

15.0

592.0

Repeat

Note=WD 6

Hgene

FBXW11

chr5:171433462

chr7:6439757

ENST00000393802

490_527

15.0

592.0

Repeat

Note=WD 7

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000348035

32_40

75.0

193.0

Motif

Effector region

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000356142

32_40

94.0

212.0

Motif

Effector region

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000348035

13_18

75.0

193.0

Nucleotide binding

GTP

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000348035

30_35

75.0

193.0

Nucleotide binding

GTP

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000356142

13_18

94.0

212.0

Nucleotide binding

GTP

Tgene

RAC1

chr5:171433462

chr7:6439757

ENST00000356142

30_35

94.0

212.0

Nucleotide binding

GTP

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Fusion Gene Sequence for FBXW11-RAC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000296933_ENST00000348035_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(transcript)=2301nt_BP=416nt
GTAGTCGTGGCGCTCTCGAGGCCCTGCCATGAGCAAGCTCTTAACTCTTCAGGTCTGCACGTCCTACGCCCACCGTCCAGTGCTACTCTC
AGCTCGGAGTTCAGCTTCGGGCTGCCAAGAGCCAGCAACCTGGTGTCAGAGGCTCGGTCCCACAACGCTCTGCGGGCCGCGGCGCCTGCT
GGGAGGTGTAGTCCCCGATCTGCGTACTGCGTTCGCCGAGGGGGAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGG
TGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCG
CCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTC
CTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAAC
TTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTA
AGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCC
TCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAAATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACC
TTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAAAAAACAAAAAAAAAAAACAACGGTGGAGCCTTCGCACTCAATGCCAACTTTTTGTT
ACAGATTAATTTTTCCATAAAACCATTTTTTGAACCAATCAGTAATTTTAAGGTTTTGTTTGTTCTAAATGTAAGAGTTCAGACTCACAT
TCTATTAAAATTTAGCCCTAAAATGACAAGCCTTCTTAAAGCCTTATTTTTCAAAAGCGCCCCCCCCATTCTTGTTCAGATTAAGAGTTG
CCAAAATACCTTCTGAACTACACTGCATTGTTGTGCCGAGAACACCGAGCACTGAACTTTGCAAAGACCTTCGTCTTTGAGAAGACGGTA
GCTTCTGCAGTTAGGAGGTGCAGACACTTGCTCTCCTATGTAGTTCTCAGATGCGTAAAGCAGAACAGCCTCCCGAATGAAGCGTTGCCA
TTGAACTCACCAGTGAGTTAGCAGCACGTGTTCCCGACATAACATTGTACTGTAATGGAGTGAGCGTAGCAGCTCAGCTCTTTGGATCAG
TCTTTGTGATTTCATAGCGAGTTTTCTGACCAGCTTTTGCGGAGATTTTGAACAGAACTGCTATTTCCTCTAATGAAGAATTCTGTTTAG
CTGTGGGTGTGCCGGGTGGGGTGTGTGTGATCAAAGGACAAAGACAGTATTTTGACAAAATACGAAGTGGAGATTTACACTACATTGTAC
AAGGAATGAAAGTGTCACGGGTAAAAACTCTAAAAGGTTAATTTCTGTCAAATGCAGTAGATGATGAAAGAAAGGTTGGTATTATCAGGA
AATGTTTTCTTAAGCTTTTCCTTTCTCTTACACCTGCCATGCCTCCCCAAATTGGGCATTTAATTCATCTTTAAACTGGTTGTTCTGTTA
GTCGCTAACTTAGTAAGTGCTTTTCTTATAGAACCCCTTCTGACTGAGCAATATGCCTCCTTGTATTATAAAATCTTTCTGATAATGCAT
TAGAAGGTTTTTTTGTCGATTAGTAAAAGTGCTTTCCATGTTACTTTATTCAGAGCTAATAAGTGCTTTCCTTAGTTTTCTAGTAACTAG
GTGTAAAAATCATGTGTTGCAGCTTTATAGTTTTTAAAATATTTTAGATAATTCTTAAACTATGAACCTTCTTAACATCACTGTCTTGCC
AGATTACCGACACTGTCACTTGACCAATACTGACCCTCTTTACCTCGCCCACGCGGACACACGCCTCCTGTAGTCGCTTTGCCTATTGAT
GTTCCTTTGGGTCTGTGAGGTTCTGTAAACTGTGCTAGTGCTGACGATGTTCTGTACAACTTAACTCACTGGCGAGAATACAGCGTGGGA
CCCTTCAGCCACTACAACAGAATTTTTTAAATTGACAGTTGCAGAATTGTGGAGTGTTTTTACATTGATCTTTTGCTAATGCAATTAGCA

>In-frame_ENST00000296933_ENST00000348035_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(amino acids)=159AA_start in transcript=290_stop in transcript=769
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK

--------------------------------------------------------------
>In-frame_ENST00000296933_ENST00000356142_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(transcript)=844nt_BP=416nt
GTAGTCGTGGCGCTCTCGAGGCCCTGCCATGAGCAAGCTCTTAACTCTTCAGGTCTGCACGTCCTACGCCCACCGTCCAGTGCTACTCTC
AGCTCGGAGTTCAGCTTCGGGCTGCCAAGAGCCAGCAACCTGGTGTCAGAGGCTCGGTCCCACAACGCTCTGCGGGCCGCGGCGCCTGCT
GGGAGGTGTAGTCCCCGATCTGCGTACTGCGTTCGCCGAGGGGGAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGG
TGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCG
CCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTC
CTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAAC
TTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTA
AGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCC
TCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAAATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACC

>In-frame_ENST00000296933_ENST00000356142_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(amino acids)=166AA_start in transcript=600_stop in transcript=100
MGVSFFSFSFSIVSLSSLRSSLVPTRMMGVLGQWCRTSGYHFARTFSNDAGLTREKQIKNTSMSSMVLSSITESGSMAAPAAPPRSPRAA

--------------------------------------------------------------
>In-frame_ENST00000265094_ENST00000348035_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(transcript)=2068nt_BP=183nt
CTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGG
CCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTC
ATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCACCAC
TGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTG
ACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGAGGC
CTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAAATG
TCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACCTTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAAAAAACAAAAAAAAAAAACA
ACGGTGGAGCCTTCGCACTCAATGCCAACTTTTTGTTACAGATTAATTTTTCCATAAAACCATTTTTTGAACCAATCAGTAATTTTAAGG
TTTTGTTTGTTCTAAATGTAAGAGTTCAGACTCACATTCTATTAAAATTTAGCCCTAAAATGACAAGCCTTCTTAAAGCCTTATTTTTCA
AAAGCGCCCCCCCCATTCTTGTTCAGATTAAGAGTTGCCAAAATACCTTCTGAACTACACTGCATTGTTGTGCCGAGAACACCGAGCACT
GAACTTTGCAAAGACCTTCGTCTTTGAGAAGACGGTAGCTTCTGCAGTTAGGAGGTGCAGACACTTGCTCTCCTATGTAGTTCTCAGATG
CGTAAAGCAGAACAGCCTCCCGAATGAAGCGTTGCCATTGAACTCACCAGTGAGTTAGCAGCACGTGTTCCCGACATAACATTGTACTGT
AATGGAGTGAGCGTAGCAGCTCAGCTCTTTGGATCAGTCTTTGTGATTTCATAGCGAGTTTTCTGACCAGCTTTTGCGGAGATTTTGAAC
AGAACTGCTATTTCCTCTAATGAAGAATTCTGTTTAGCTGTGGGTGTGCCGGGTGGGGTGTGTGTGATCAAAGGACAAAGACAGTATTTT
GACAAAATACGAAGTGGAGATTTACACTACATTGTACAAGGAATGAAAGTGTCACGGGTAAAAACTCTAAAAGGTTAATTTCTGTCAAAT
GCAGTAGATGATGAAAGAAAGGTTGGTATTATCAGGAAATGTTTTCTTAAGCTTTTCCTTTCTCTTACACCTGCCATGCCTCCCCAAATT
GGGCATTTAATTCATCTTTAAACTGGTTGTTCTGTTAGTCGCTAACTTAGTAAGTGCTTTTCTTATAGAACCCCTTCTGACTGAGCAATA
TGCCTCCTTGTATTATAAAATCTTTCTGATAATGCATTAGAAGGTTTTTTTGTCGATTAGTAAAAGTGCTTTCCATGTTACTTTATTCAG
AGCTAATAAGTGCTTTCCTTAGTTTTCTAGTAACTAGGTGTAAAAATCATGTGTTGCAGCTTTATAGTTTTTAAAATATTTTAGATAATT
CTTAAACTATGAACCTTCTTAACATCACTGTCTTGCCAGATTACCGACACTGTCACTTGACCAATACTGACCCTCTTTACCTCGCCCACG
CGGACACACGCCTCCTGTAGTCGCTTTGCCTATTGATGTTCCTTTGGGTCTGTGAGGTTCTGTAAACTGTGCTAGTGCTGACGATGTTCT
GTACAACTTAACTCACTGGCGAGAATACAGCGTGGGACCCTTCAGCCACTACAACAGAATTTTTTAAATTGACAGTTGCAGAATTGTGGA

>In-frame_ENST00000265094_ENST00000348035_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(amino acids)=159AA_start in transcript=57_stop in transcript=536
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK

--------------------------------------------------------------
>In-frame_ENST00000265094_ENST00000356142_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(transcript)=611nt_BP=183nt
CTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGG
CCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTC
ATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCACCAC
TGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTG
ACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGAGGC
CTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAAATG

>In-frame_ENST00000265094_ENST00000356142_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(amino acids)=159AA_start in transcript=57_stop in transcript=536
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK

--------------------------------------------------------------
>In-frame_ENST00000393802_ENST00000348035_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(transcript)=2078nt_BP=193nt
GAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCC
TCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGAC
CATCGAGCTCATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGT
GCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGA
GAAGAAGCTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCAC
ACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCT
GTTGTAAATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACCTTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAAAAAACAAAA
AAAAAAAACAACGGTGGAGCCTTCGCACTCAATGCCAACTTTTTGTTACAGATTAATTTTTCCATAAAACCATTTTTTGAACCAATCAGT
AATTTTAAGGTTTTGTTTGTTCTAAATGTAAGAGTTCAGACTCACATTCTATTAAAATTTAGCCCTAAAATGACAAGCCTTCTTAAAGCC
TTATTTTTCAAAAGCGCCCCCCCCATTCTTGTTCAGATTAAGAGTTGCCAAAATACCTTCTGAACTACACTGCATTGTTGTGCCGAGAAC
ACCGAGCACTGAACTTTGCAAAGACCTTCGTCTTTGAGAAGACGGTAGCTTCTGCAGTTAGGAGGTGCAGACACTTGCTCTCCTATGTAG
TTCTCAGATGCGTAAAGCAGAACAGCCTCCCGAATGAAGCGTTGCCATTGAACTCACCAGTGAGTTAGCAGCACGTGTTCCCGACATAAC
ATTGTACTGTAATGGAGTGAGCGTAGCAGCTCAGCTCTTTGGATCAGTCTTTGTGATTTCATAGCGAGTTTTCTGACCAGCTTTTGCGGA
GATTTTGAACAGAACTGCTATTTCCTCTAATGAAGAATTCTGTTTAGCTGTGGGTGTGCCGGGTGGGGTGTGTGTGATCAAAGGACAAAG
ACAGTATTTTGACAAAATACGAAGTGGAGATTTACACTACATTGTACAAGGAATGAAAGTGTCACGGGTAAAAACTCTAAAAGGTTAATT
TCTGTCAAATGCAGTAGATGATGAAAGAAAGGTTGGTATTATCAGGAAATGTTTTCTTAAGCTTTTCCTTTCTCTTACACCTGCCATGCC
TCCCCAAATTGGGCATTTAATTCATCTTTAAACTGGTTGTTCTGTTAGTCGCTAACTTAGTAAGTGCTTTTCTTATAGAACCCCTTCTGA
CTGAGCAATATGCCTCCTTGTATTATAAAATCTTTCTGATAATGCATTAGAAGGTTTTTTTGTCGATTAGTAAAAGTGCTTTCCATGTTA
CTTTATTCAGAGCTAATAAGTGCTTTCCTTAGTTTTCTAGTAACTAGGTGTAAAAATCATGTGTTGCAGCTTTATAGTTTTTAAAATATT
TTAGATAATTCTTAAACTATGAACCTTCTTAACATCACTGTCTTGCCAGATTACCGACACTGTCACTTGACCAATACTGACCCTCTTTAC
CTCGCCCACGCGGACACACGCCTCCTGTAGTCGCTTTGCCTATTGATGTTCCTTTGGGTCTGTGAGGTTCTGTAAACTGTGCTAGTGCTG
ACGATGTTCTGTACAACTTAACTCACTGGCGAGAATACAGCGTGGGACCCTTCAGCCACTACAACAGAATTTTTTAAATTGACAGTTGCA
GAATTGTGGAGTGTTTTTACATTGATCTTTTGCTAATGCAATTAGCATTATGTTTTGCATGTATGACTTAATAAATCCTTGAATCATACG

>In-frame_ENST00000393802_ENST00000348035_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(amino acids)=159AA_start in transcript=67_stop in transcript=546
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK

--------------------------------------------------------------
>In-frame_ENST00000393802_ENST00000356142_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(transcript)=621nt_BP=193nt
GAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCC
TCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGAC
CATCGAGCTCATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGT
GCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGA
GAAGAAGCTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCAC
ACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCT

>In-frame_ENST00000393802_ENST00000356142_TCGA-FP-8209-01A_FBXW11_chr5_171433462_-_RAC1_chr7_6439757_length(amino acids)=159AA_start in transcript=67_stop in transcript=546
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FBXW11-RAC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for FBXW11-RAC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for FBXW11-RAC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FBXW11	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Hgene	FBXW11	C2677504	AUTISM, SUSCEPTIBILITY TO, 15	1	GENOMICS_ENGLAND
Hgene	FBXW11	C3550704	Abnormality of digit	1	GENOMICS_ENGLAND
Hgene	FBXW11	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Hgene	FBXW11	C4021812	Abnormality of the head	1	GENOMICS_ENGLAND
Hgene	FBXW11	C4316870	Abnormality of the eye	1	GENOMICS_ENGLAND
Tgene	RAC1	C0011570	Mental Depression	2	PSYGENET
Tgene	RAC1	C0011581	Depressive disorder	2	PSYGENET
Tgene	RAC1	C0007193	Cardiomyopathy, Dilated	1	CTD_human
Tgene	RAC1	C0007621	Neoplastic Cell Transformation	1	CTD_human
Tgene	RAC1	C0011849	Diabetes Mellitus	1	CTD_human
Tgene	RAC1	C0018801	Heart failure	1	CTD_human
Tgene	RAC1	C0018802	Congestive heart failure	1	CTD_human
Tgene	RAC1	C0023212	Left-Sided Heart Failure	1	CTD_human
Tgene	RAC1	C0023895	Liver diseases	1	CTD_human
Tgene	RAC1	C0025202	melanoma	1	CGI;CTD_human
Tgene	RAC1	C0027627	Neoplasm Metastasis	1	CTD_human
Tgene	RAC1	C0086565	Liver Dysfunction	1	CTD_human
Tgene	RAC1	C0235527	Heart Failure, Right-Sided	1	CTD_human
Tgene	RAC1	C0242698	Ventricular Dysfunction, Left	1	CTD_human
Tgene	RAC1	C0424605	Developmental delay (disorder)	1	GENOMICS_ENGLAND
Tgene	RAC1	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Tgene	RAC1	C0876994	Cardiotoxicity	1	CTD_human
Tgene	RAC1	C1449563	Cardiomyopathy, Familial Idiopathic	1	CTD_human
Tgene	RAC1	C1959583	Myocardial Failure	1	CTD_human
Tgene	RAC1	C1961112	Heart Decompensation	1	CTD_human
Tgene	RAC1	C2239176	Liver carcinoma	1	CTD_human
Tgene	RAC1	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Tgene	RAC1	C4540321	MENTAL RETARDATION, AUTOSOMAL DOMINANT 48	1	ORPHANET;UNIPROT