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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FCHSD2-RNF169 (FusionGDB2 ID:29930)

Fusion Gene Summary for FCHSD2-RNF169

check button Fusion gene summary
Fusion gene informationFusion gene name: FCHSD2-RNF169
Fusion gene ID: 29930
HgeneTgene
Gene symbol

FCHSD2

RNF169

Gene ID

9873

254225

Gene nameFCH and double SH3 domains 2ring finger protein 169
SynonymsNWK|NWK1|SH3MD3-
Cytomap

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
DescriptionF-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homologprotein nervous wreck 1E3 ubiquitin-protein ligase RNF169RING-type E3 ubiquitin transferase RNF169
Modification date2020031320200313
UniProtAcc

O94868

.
Ensembl transtripts involved in fusion geneENST00000311172, ENST00000409314, 
ENST00000409418, ENST00000458644, 
ENST00000409853, ENST00000409263, 
ENST00000299563, 
Fusion gene scores* DoF score43 X 26 X 16=1788810 X 8 X 5=400
# samples 5913
** MAII scorelog2(59/17888*10)=-4.92213332859399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/400*10)=-1.62148837674627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FCHSD2 [Title/Abstract] AND RNF169 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFCHSD2(72613588)-RNF169(74500671), # samples:3
Anticipated loss of major functional domain due to fusion event.FCHSD2-RNF169 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRNF169

GO:0006974

cellular response to DNA damage stimulus

22733822

TgeneRNF169

GO:2000780

negative regulation of double-strand break repair

22742833


check buttonFusion gene breakpoints across FCHSD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RNF169 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A201-01AFCHSD2chr11

72613588

-RNF169chr11

74500671

+
ChimerDB4BRCATCGA-BH-A201FCHSD2chr11

72613587

-RNF169chr11

74500670

+
ChimerDB4BRCATCGA-BH-A201-01AFCHSD2chr11

72613588

-RNF169chr11

74500671

+
ChimerDB4BRCATCGA-BH-A201-01AFCHSD2chr11

72613588

-RNF169chr11

74500671

+


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Fusion Gene ORF analysis for FCHSD2-RNF169

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000311172ENST00000299563FCHSD2chr11

72613588

-RNF169chr11

74500671

+
Frame-shiftENST00000409314ENST00000299563FCHSD2chr11

72613588

-RNF169chr11

74500671

+
Frame-shiftENST00000409418ENST00000299563FCHSD2chr11

72613588

-RNF169chr11

74500671

+
Frame-shiftENST00000458644ENST00000299563FCHSD2chr11

72613588

-RNF169chr11

74500671

+
In-frameENST00000409853ENST00000299563FCHSD2chr11

72613588

-RNF169chr11

74500671

+
intron-3CDSENST00000409263ENST00000299563FCHSD2chr11

72613588

-RNF169chr11

74500671

+
Frame-shiftENST00000311172ENST00000299563FCHSD2chr11

72613587

-RNF169chr11

74500670

+
Frame-shiftENST00000409314ENST00000299563FCHSD2chr11

72613587

-RNF169chr11

74500670

+
Frame-shiftENST00000409418ENST00000299563FCHSD2chr11

72613587

-RNF169chr11

74500670

+
Frame-shiftENST00000458644ENST00000299563FCHSD2chr11

72613587

-RNF169chr11

74500670

+
In-frameENST00000409853ENST00000299563FCHSD2chr11

72613587

-RNF169chr11

74500670

+
intron-3CDSENST00000409263ENST00000299563FCHSD2chr11

72613587

-RNF169chr11

74500670

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409853FCHSD2chr1172613588-ENST00000299563RNF169chr1174500671+81978899542513519
ENST00000409853FCHSD2chr1172613587-ENST00000299563RNF169chr1174500670+81978899542513519

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409853ENST00000299563FCHSD2chr1172613588-RNF169chr1174500671+0.0018887730.99811125
ENST00000409853ENST00000299563FCHSD2chr1172613587-RNF169chr1174500670+0.0018887730.99811125

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Fusion Genomic Features for FCHSD2-RNF169


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FCHSD2chr1172613587-RNF169chr1174500670+9.91E-060.9999901
FCHSD2chr1172613587-RNF169chr1174500670+9.91E-060.9999901
FCHSD2chr1172613587-RNF169chr1174500670+9.91E-060.9999901
FCHSD2chr1172613587-RNF169chr1174500670+9.91E-060.9999901

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FCHSD2-RNF169


check button Go to

FGviewer for the breakpoints of chr11:72613588-chr11:74500671

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCHSD2

O94868

.
FUNCTION: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409418-10208_282308.0741.0DomainF-BAR
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409418-10208_282308.0741.0DomainF-BAR
TgeneRNF169chr11:72613587chr11:74500670ENST0000029956306205_213167.33333333333334709.0MotifNote=UMI motif
TgeneRNF169chr11:72613587chr11:74500670ENST0000029956306665_682167.33333333333334709.0MotifNote=MIU motif
TgeneRNF169chr11:72613587chr11:74500670ENST0000029956306689_701167.33333333333334709.0MotifNote=LR motif
TgeneRNF169chr11:72613588chr11:74500671ENST0000029956306205_213167.33333333333334709.0MotifNote=UMI motif
TgeneRNF169chr11:72613588chr11:74500671ENST0000029956306665_682167.33333333333334709.0MotifNote=MIU motif
TgeneRNF169chr11:72613588chr11:74500671ENST0000029956306689_701167.33333333333334709.0MotifNote=LR motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000311172-919356_397252.0685.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409418-1020356_397308.0741.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409853-1016356_397252.0516.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000311172-919356_397252.0685.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409418-1020356_397308.0741.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409853-1016356_397252.0516.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000311172-919718_721252.0685.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409418-1020718_721308.0741.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409853-1016718_721252.0516.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000311172-919718_721252.0685.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409418-1020718_721308.0741.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409853-1016718_721252.0516.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000311172-919469_530252.0685.0DomainSH3 1
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000311172-9198_282252.0685.0DomainF-BAR
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409418-1020469_530308.0741.0DomainSH3 1
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409853-1016469_530252.0516.0DomainSH3 1
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409853-10168_282252.0516.0DomainF-BAR
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000311172-919469_530252.0685.0DomainSH3 1
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000311172-9198_282252.0685.0DomainF-BAR
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409418-1020469_530308.0741.0DomainSH3 1
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409853-1016469_530252.0516.0DomainSH3 1
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409853-10168_282252.0516.0DomainF-BAR
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000311172-919567_629252.0685.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409418-1020567_629308.0741.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72613587chr11:74500670ENST00000409853-1016567_629252.0516.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000311172-919567_629252.0685.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409418-1020567_629308.0741.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72613588chr11:74500671ENST00000409853-1016567_629252.0516.0RegionRequired and sufficient for location at clathrin-coated pits
TgeneRNF169chr11:72613587chr11:74500670ENST000002995630668_107167.33333333333334709.0Zinc fingerRING-type
TgeneRNF169chr11:72613588chr11:74500671ENST000002995630668_107167.33333333333334709.0Zinc fingerRING-type


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Fusion Gene Sequence for FCHSD2-RNF169


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000409853_ENST00000299563_TCGA-BH-A201-01A_FCHSD2_chr11_72613588_-_RNF169_chr11_74500671_length(transcript)=8197nt_BP=889nt
AAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGTATTCCATTGTAT
GGATATACCACAGTTTATCCATTTTCCTGTTGATGGACATGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGT
AAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGAT
GAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGA
CCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGC
TCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAA
GTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCA
GGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTT
CAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGGTGGTCCGGGACTACAA
TCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTGATACTACTTTATATTC
AGAGCACCAATCAAATTAAGCAAGCCTGGGGAACTTCGTGAGGAATATGAAAGCTTGAGAAAGCTGAGAGAAGAAAAGTTACAAGAGGAA
AAACCCTCTGAAGATCAAATCCACAAGCTGTTACCAGAGGATACAGAAACAGGGAAAAGGAAAATGGATGAACAGAAAAAAAGAGATGAA
CCATTAGTACTGAAAACAAATCTGGAACGTTGTCCTGCACGTCTCTCAGATTCAGAGAATGAAGAACCTTCTCGAGGCCAGATGACACAG
ACACATCGCTCGGCATTTGTTTCCAAGAACAACTCCTACTCCTTAGCTTTCCTGGCAGGGAAGCTAAACTCCAAGGTGGAAAGGAGTCAG
AGCTGTAGTGACACAGCCCAGGAAAGAGCGAAGAGCAGAGTCAGAGCAGTTCCAGGCAACAAAGCCAAGGTCACAACTATGACTCCAGCC
TCCAACCCCATCATTGGTGTCCTCTTGTCAACTCAAAACAACCGCTGCGTCTCGGCCCCTGACTTAACCATCGAAAAGCGTCTACCCTTC
AGCTCCCTTTCATCCTTGGCTTCCCTGCATAAGCCAGAGCGTTCTGTCAGCCCTGAGAGCAATGACAGCATCTCCGAAGAACTAAACCAT
TTCAAGCCCATTGTCTGCTCACCATGTACTCCTCCCAAGAGACTCCCTGATGGCCGTGTGCTAAGTCCTCTCATCATCAAATCAACTCCA
CGCAACCTAAACAGAAGCCTGCAGAAGCAGACTTCTTATGAGGCCAGTCCACGGATCCTCAAAAAGTGGGAACAGATCTTTCAGGAGCGG
CAGATCAAAAAGACCCTTTCAAAAGCCACTCTTACCTCTCTGGCTCCTGAAATGGGGGAAGAGTTACTAGGCTCTGAAGGTATCCATTCT
AGCAAGGAGAAGCCACTTGTGGCTGTAAATACAAGATTATCTGGTGGGCAGGTCCTCTCTGAGTATACTGGACCCACCTCTGCTGATCTT
GATCATTTCCCCTCTGTTAGCCAAACAAAAGCAGAACAGGACAGTGATAATAAAAGTAGCACTGAGATCCCACTGGAAACCTGCTGTTCC
TCAGAACTCAAAGGGGGAGGCAGTGGGACTTCTTTGGAGAGGGAGCAGTTTGAGGGGTTAGGGTCAACTCCAGATGCCAAGTTAGACAAA
ACCTGTATAAGCAGAGCCATGAAAATCACCACAGTTAATTCAGTGCTACCCCAAAACAGTGTTTTGGGTGGAGTCCTCAAAACAAAGCAA
CAATTGAAGACATTAAATCATTTTGATCTGACTAATGGTGTTCTAGTTGAGAGCCTAAGTGAAGAGCCACTTCCTTCTTTGCGTCGAGGC
CGGAAAAGACACTGCAAGACCAAGCACTTAGAACAAAATGGCTCCCTTAAAAAACTGCGACAAACCAGTGGGGAGGTGGGTCTGGCCCCA
ACAGACCCAGTCCTGCGAGAGATGGAGCAGAAGCTTCAGCAAGAGGAAGAAGACCGACAGTTGGCTCTGCAGTTGCAGCGCATGTTCGAC
AATGAGAGGCGGACTGTGAGCCGGCGAAAAGGAAGTGTGGATCAGTATCTCCTACGGTCCAGCAACATGGCCGGGGCCAAGTAGCACCTA
ATGAAGTGTTACCTATTTTTAAAAGGTCTTAGGCCTTGATCATTTATCCTGAAGAGCTGAGTGTTCTCACTTTGGTTTTATTTTAATGGC
AAAACACTGTCTAATATGGTTCTGAGAGGTTCCAGGGCCTTTGTAGTCAATATCCAAGGGAAAAGCATCTCCGTTTCTCTGTGACCCAGG
CCAGAAGCCTGAGTGACCCATCCCTAAGGGCTTCTGGGCCAAACCTGGCAGCACCCACTGGGAATGAGATTTGGAACGGCCTCAGGAGCA
TAATGGCCACAGTTAGTAATGGTAAAGAGGGGATACCTTCTTAAACTGATAGACTTCCTGACTTCTTTCAGCAGGGTATTGTTTTAAATC
AGCCTTGCAGATAAAAATTAATTCCATCTTTTTCAGACAAGTGAACAATTTAGTTCCTTGGCAGATCCAAAATGATAGATGGTTATGTTA
CGCTTTCTGCTGTCCCTTGCCAAAAATAAGTAAATATATCAGTTAAGATTATGCCTTTACAAAAGTTAATTTACATTCTCTGTTTAAAAA
ATAATATTTGGTGAATGCTATATAGTTGACAGAGCACATTTACAGACCTTATTAATTTAGTCTTTCCAAGAGACCTCTCATGTAACTGGC
ATTAGCCCCATTTTTAGATGATGAAACTGCAGTGCAGATGTTCTGGTTCTCTCAACTACCAAGTGGCATAACCCATGGATTTTCTAAAGG
TTTCCCAAATAGATCACAACCTAAGGGTGTGCCAGGGGAGCCTAGGGGAAGCTAGGCTGGGCATTGAACACTGATAGTGCAGAATCCACA
TGCAAACAAGATCGACAGGGTGGATAAACATATATGTGCATTATCCCCATCCCCCACAGTTTAGAGCCTTCTGCTTTTCTGGGGGTTTCA
GCCTATGAGACAAACTATAATCAGGCTTCATTATTACTTTTCAAATGGCCAAGGGTTATCTGCAATGTTGATCTAAAATCCTAAAAAATC
ACCCTGAAGTCAGGCAAGGAACAATACTTAAACTCCATACTATGGAAACAAGGTATCTAGCTGGATGCAGCTGGTAAATTCAGTCCCATG
GACCTTTGGGGGTTTATTTTCCTTAGCAGCTGACACCATGTGTCTTTTGCATCCCTGGTGGTGCTTGGTGCTTCTGCCCATCTGGGCTCA
TTGAGAATAGGGATGAAGATATGATTTTAGGGAATTTCTGATGGGCTGGCATGCCCCATGTAGTATGAGTTACTATATAAAGTCATGTGA
CTGGCATTTTAACAGACCTTCCAGAGCTTATATATCCCAATATATGTTGTTTCCTTTGAGTAGCCCCAGCAGGATACTGCTTAGTTTTTC
CAGTGCCATTGGTGAAAGCATTTCTGGAACTGTCTTCAAAGACTAGAAACACTGACTCCCAAAATGCTAGAACTGGAAGGGACCTTAATG
GTTATCTATTCCAGCCTCCTCCTAAGGTCCTCCTCAGCTTCTAGACCTAGAAGCCAAAGTCCAGAACAGTGACCCATTGATCAAGGCAGA
TAGTATAACTCCTTTTAAGTGTTCTCAGATTTGCCTTTTCTCAGGGCAAATCTTCAGTGTTTTGTGGTTATTTGTGGTTGAGAGAGAGAG
AGAATGTAATGTCTGAGACTAGCCAGCAGCTATTTGAAGCCTCTGGGAAAGAAGGTGGCTTATCAAGTGGGTTTGTAGTAATGAGTGCTG
CTGTAAAGCAGAGCCATTTTCTTGTGCAGCTCATAGTTCCCAAACAGTTCCCAAACAGAAATTCCAGAGATGTCTTAAACATTGTGGTCA
TCATTGAGATAGGTGGAATCTCTTTGGTGACTACGTTGGTGGGGAACATCACTCACCTGAATGTATGCATTCTGTGTTCTCTGTGTGTGT
GCACATATGCAGATGTATGTTTTAAAAACATTTACCAAACTCATGATTTTGTAGTCACACCACTTCAGTTCTGGGCCCTACCAACAATTT
ATGTCCTCCAAGAGCTGCTGGAGGGCATGTTTGTGCCCAAAACAGAAGAGCTGGCTCTGGTTTACAGAAGACAGGGAGGGTGACCTTACT
ATAAATGCCCTTAGAGGAAACTTATCAGTTACTGCCATTTCACGCATTTCCTTTTTGATCTTAGTAAATATTATTGGAAGGCTAGTCTTG
TTGGTAGGAGCAAAGACACTTATTTTTCCACTTGCCATCTTTCTCTATATCTCCAGTAATTTGAAAAACACTTTTCAGTTGGAATTGATT
TTTGTCTTTGGTAAAAAGAAATATTTTTAATAGATAAAAGATATATATTTTAAATATTTCCCCAAATTAATACTTTCATTTTAAGAATTG
CATAGCAGTTGTAACAAGTGCAGAATGAAGAACAAATTCTTGTTAAGCAAATAGTCCAAACTCTAGGTCCAGCTTACTGCCTTCCCCCCT
TGTACCTACAGTGATGCCTAGGATGGTATTGACAGTTGTTTTCTAAACTTCCTGCTGAGCAACAGTCCTTCAAATATAGGTAGAGTGGTC
TAGGTTAAGGAGGGAGGAGGGTTGATCTTTAATCAGGTTGGCTTTGGAGGAAGGAAAAACCACTAAGGTATTATCTGAATTTTAAGATGC
TTCCCATCCTTAATAACTAAAACCTGAATGCTTTTCTTTCTGAAAAATCTCCCTCTCTCCTTCCATGATTCTGAAGTTGGTTAAAAGTCG
ATATGTTGATGTGTATTATTTGGGGGAACAGAAAAGGACAAGGAAGGAAACAGAACGATGGGAAGGGTTTGTGAGCTAGAATAAGAGGTG
CAGGATTTCACAAAACAAATTCCTCACAAATCATTGAAGCCCAGTTCACCATACAAATTACCCATGTCTTACTCTGTTCCTTGTATATAT
GCATTCTGGGTTTTTTTATTATTAAAGGGGAAGTTAGGGGGGAGGGTGAAGGTCAGTCTGAGGGGAAATCCAGGAAATGTGGTGCCCTTA
GAAGGGGGCTGTCAGCTCTTTTCCATAGAGAGGGAAAGAAACTTTGAGAAAATGTTCTTGACCCATTGATTGTATCTGCTGGAAGAAGTC
ATCTGGGCCTGTTGGGTTGGTATCAGATCAGGGGATTATGCATCCAGCCCCTGGCCCCTTTAATCTATTTGCCTCTTTTTAAAAAAGGTT
AAGTCTTCTTGGGTGAGGCTTGCCAGGGAAACTCCTAAGTGGCTTCACTTATTTTTTAAATTTTAATTTAATTTTTAAATTTTTGCTTGG
AAGCAGCACTGGTAATAAATGTTTTATTTTTTGTTCATTTTCCCTAAAGGAAAAATGTCCTTAAGAGATTAAAGCTCTTAATTGATTACT
GTCTGGTTACAAACTGGCAAACTGACTAAAATGGGAAGCTGCCACCGTGCCTGACTCATGTAGCTGATGACCGAAGGCTCATCCTTTCTT
TTCTATTTGACAGACATTTACTGAGCTTCAGACTTGAGCCAACCCTGAGCTGGACTGTGGAGATAAAGCAGTTCCTGCTCTTGAGGAGCT
CAATGTCTAATGGAATGCATTTGAATGTATGTGTGGCTGGAGAGTTCATTTATGGTCTTAGGAAAGCCATTTCTGGTCCCATTTAGAAAA
CTGACCAGCACCCAGCAAGCTGCATTCTACATTTTAGAGACCCCATTGGTATTTGTGAATTTGATTGCACCACCGCTTTTCCTTTACTAA
GTAATGTTATGGAAGGAGAATGAATTTTCTCCTCTAGTGATTACAGGACATTAACATCTCTTCAGAAGCTGCTTTTAGCTTAAGCCCCAA
GAAGTGAGGTGGGTTGTGGATCACTGACATGGTCAGGGGAGGCCCACACCTCAATTCAGTAACCACCTAATCTCTCCCCCAACCTGATCT
CTCATCAGAGCTGGCAGCAACTTGGGATTCCTTTCCTTTTTCCTGCCTAACTTTTCATTGAAATGTCTAGTAGGAGAGTGAGAAAAGAGA
ACAAAGGCTGGGTCACAGTCATAGAATGTTACAGCTGGAATGGGCATGGAAATCATCCAAGTTAAACTTCTTCTCTGCCCCCCGCCCCCA
CTTTTTTTTTTTTTTTTTTTTAACCAAACGAACTTGTGATCCAGTGCCCTATTTTATAGTGTGGTTTTCCAGGGTCTGAATAAATAATCA
TTAAAGTTTGACACACGCAGACACACGCACCAATGATGGGGATACCCCCAAATGATTTAGGAGGTTATTTTATTTTAATAGTTTTTTCTT
CCTGATTTTTTTCAGTTAGTTAGAGTTAAATGTACCTATAGCCCCTGAATACATGCTCAGGTAGAGAAAGTCTCCATAGTATAAGTAAGT
AATATGAATGTGGAATCTTGGAAAGTGATATATTTTGATTGGAATAATTTTAATTAAATTTAATGATTTTAATTAAGAATTAAAAGCCAG
CTAGCCAAATTTTCTTTAAAAATTGGAAACTCATTATGGTCTTAAATTGTCCTCAGGCAGCCTTTTCCTCATCAACCCATAGAGTGGTCT
TTTGAACTGGTATCTAAACATACCTGGTTATGAATTCTCAAAAGAGAAAGCAGGTCTGGGGCGGGGTGGTCAGGAGACAGATTCTAGGGA
AAGTGCTGAAGAGATTTTCTTCTGAAGATGATCTAGGAAATGCATCTTTATACATGATTGTTAGCTGCTGTAGCTTTCTGAAGAAGATTG
TAGAAAAGAGACTAAGATATATGCAAGGGTCACCAGTTTAGAGATCAGTCAAATTGGAAAAAGTGCCAAGACTGGATGTGCAGATTGTTC
TATGTATTATCAGTATTTTTTTCCTCTTAAGAAAAAAATTTACTCTCTCTCCTTTGTGAGTAAATGCCTCCTTAATGCCTTTTAAGTAAG
GTGGCAACTTTTAACTGTCATCTTGTGAGAGGCAACCTCAAACTCTAAGCAGACTCCCTCTCTCCCTTTCTGGTGTCTTAAATCAAGAAC
TAGTTTGAAGCCAAGGCAAAGCAAGGTTTGTTCATCTTCCTTTCCTGTCATTTAAGGTAAAACAGGCAATGAACTCGCTCTTCAAATACC
ATAGTTCAAGAGTAGCTGTTGGCCCTGGTTCCAGATTAATATAGCAGCAGGCAGATTGCCCCTTCTTGGGGCCACCACCCTCCAAAGCTG
TGCCACCAATGAGAGCATTGGGTTCAAGTTTGCATCAAACATGGTATTACCAACGCTGAGCCTCCAGCAGAGCACTTAAAAGTCCTAGTG
AGAGAATAGATACTATGCAAGGGAAAAAAATTTAAATGCCAACGAATAGTTTTTTTTTTTTTGAACCTGATACACTGTTTGTTTACTCTC
AACTCTTTGTACAAATATTATTGTCCTAAGGGCCTTTTCCCCTCCTGCCTAGAAAATAGGTTGTGTATTGGTTTTATTCAACCTGCTGTC
TGCTTTAGGATTGGAGAAGGTACCTGGATCCTTGTGGACTGCCACTGCTGGCTGCCTCCTCTCCAACTCATCAGAAGAGCATTTTGACAA
AGACAGAGGACTTGGACCAGGGCATGCCCTGTTGGGGATGTTTCTGTCAGCAAGGACATGGCATGGAATCAAGTGGGCTGATGTGTTGTT
ATTTAAACAGTACCAAAGTGCATTCTTCAATGTATGTTTGCCTGCTTGAAGCAAGGCCCAAGTTGAGAATACAGTAAAGGAAACTCATGA

>In-frame_ENST00000409853_ENST00000299563_TCGA-BH-A201-01A_FCHSD2_chr11_72613588_-_RNF169_chr11_74500671_length(amino acids)=519AA_start in transcript=954_stop in transcript=2513
MRKLREEKLQEEKPSEDQIHKLLPEDTETGKRKMDEQKKRDEPLVLKTNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFL
AGKLNSKVERSQSCSDTAQERAKSRVRAVPGNKAKVTTMTPASNPIIGVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSP
ESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEM
GEELLGSEGIHSSKEKPLVAVNTRLSGGQVLSEYTGPTSADLDHFPSVSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFE
GLGSTPDAKLDKTCISRAMKITTVNSVLPQNSVLGGVLKTKQQLKTLNHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKK

--------------------------------------------------------------
>In-frame_ENST00000409853_ENST00000299563_TCGA-BH-A201_FCHSD2_chr11_72613587_-_RNF169_chr11_74500670_length(transcript)=8197nt_BP=889nt
AAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGTATTCCATTGTAT
GGATATACCACAGTTTATCCATTTTCCTGTTGATGGACATGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGT
AAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGAT
GAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGA
CCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGC
TCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAA
GTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCA
GGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTT
CAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGGTGGTCCGGGACTACAA
TCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTGATACTACTTTATATTC
AGAGCACCAATCAAATTAAGCAAGCCTGGGGAACTTCGTGAGGAATATGAAAGCTTGAGAAAGCTGAGAGAAGAAAAGTTACAAGAGGAA
AAACCCTCTGAAGATCAAATCCACAAGCTGTTACCAGAGGATACAGAAACAGGGAAAAGGAAAATGGATGAACAGAAAAAAAGAGATGAA
CCATTAGTACTGAAAACAAATCTGGAACGTTGTCCTGCACGTCTCTCAGATTCAGAGAATGAAGAACCTTCTCGAGGCCAGATGACACAG
ACACATCGCTCGGCATTTGTTTCCAAGAACAACTCCTACTCCTTAGCTTTCCTGGCAGGGAAGCTAAACTCCAAGGTGGAAAGGAGTCAG
AGCTGTAGTGACACAGCCCAGGAAAGAGCGAAGAGCAGAGTCAGAGCAGTTCCAGGCAACAAAGCCAAGGTCACAACTATGACTCCAGCC
TCCAACCCCATCATTGGTGTCCTCTTGTCAACTCAAAACAACCGCTGCGTCTCGGCCCCTGACTTAACCATCGAAAAGCGTCTACCCTTC
AGCTCCCTTTCATCCTTGGCTTCCCTGCATAAGCCAGAGCGTTCTGTCAGCCCTGAGAGCAATGACAGCATCTCCGAAGAACTAAACCAT
TTCAAGCCCATTGTCTGCTCACCATGTACTCCTCCCAAGAGACTCCCTGATGGCCGTGTGCTAAGTCCTCTCATCATCAAATCAACTCCA
CGCAACCTAAACAGAAGCCTGCAGAAGCAGACTTCTTATGAGGCCAGTCCACGGATCCTCAAAAAGTGGGAACAGATCTTTCAGGAGCGG
CAGATCAAAAAGACCCTTTCAAAAGCCACTCTTACCTCTCTGGCTCCTGAAATGGGGGAAGAGTTACTAGGCTCTGAAGGTATCCATTCT
AGCAAGGAGAAGCCACTTGTGGCTGTAAATACAAGATTATCTGGTGGGCAGGTCCTCTCTGAGTATACTGGACCCACCTCTGCTGATCTT
GATCATTTCCCCTCTGTTAGCCAAACAAAAGCAGAACAGGACAGTGATAATAAAAGTAGCACTGAGATCCCACTGGAAACCTGCTGTTCC
TCAGAACTCAAAGGGGGAGGCAGTGGGACTTCTTTGGAGAGGGAGCAGTTTGAGGGGTTAGGGTCAACTCCAGATGCCAAGTTAGACAAA
ACCTGTATAAGCAGAGCCATGAAAATCACCACAGTTAATTCAGTGCTACCCCAAAACAGTGTTTTGGGTGGAGTCCTCAAAACAAAGCAA
CAATTGAAGACATTAAATCATTTTGATCTGACTAATGGTGTTCTAGTTGAGAGCCTAAGTGAAGAGCCACTTCCTTCTTTGCGTCGAGGC
CGGAAAAGACACTGCAAGACCAAGCACTTAGAACAAAATGGCTCCCTTAAAAAACTGCGACAAACCAGTGGGGAGGTGGGTCTGGCCCCA
ACAGACCCAGTCCTGCGAGAGATGGAGCAGAAGCTTCAGCAAGAGGAAGAAGACCGACAGTTGGCTCTGCAGTTGCAGCGCATGTTCGAC
AATGAGAGGCGGACTGTGAGCCGGCGAAAAGGAAGTGTGGATCAGTATCTCCTACGGTCCAGCAACATGGCCGGGGCCAAGTAGCACCTA
ATGAAGTGTTACCTATTTTTAAAAGGTCTTAGGCCTTGATCATTTATCCTGAAGAGCTGAGTGTTCTCACTTTGGTTTTATTTTAATGGC
AAAACACTGTCTAATATGGTTCTGAGAGGTTCCAGGGCCTTTGTAGTCAATATCCAAGGGAAAAGCATCTCCGTTTCTCTGTGACCCAGG
CCAGAAGCCTGAGTGACCCATCCCTAAGGGCTTCTGGGCCAAACCTGGCAGCACCCACTGGGAATGAGATTTGGAACGGCCTCAGGAGCA
TAATGGCCACAGTTAGTAATGGTAAAGAGGGGATACCTTCTTAAACTGATAGACTTCCTGACTTCTTTCAGCAGGGTATTGTTTTAAATC
AGCCTTGCAGATAAAAATTAATTCCATCTTTTTCAGACAAGTGAACAATTTAGTTCCTTGGCAGATCCAAAATGATAGATGGTTATGTTA
CGCTTTCTGCTGTCCCTTGCCAAAAATAAGTAAATATATCAGTTAAGATTATGCCTTTACAAAAGTTAATTTACATTCTCTGTTTAAAAA
ATAATATTTGGTGAATGCTATATAGTTGACAGAGCACATTTACAGACCTTATTAATTTAGTCTTTCCAAGAGACCTCTCATGTAACTGGC
ATTAGCCCCATTTTTAGATGATGAAACTGCAGTGCAGATGTTCTGGTTCTCTCAACTACCAAGTGGCATAACCCATGGATTTTCTAAAGG
TTTCCCAAATAGATCACAACCTAAGGGTGTGCCAGGGGAGCCTAGGGGAAGCTAGGCTGGGCATTGAACACTGATAGTGCAGAATCCACA
TGCAAACAAGATCGACAGGGTGGATAAACATATATGTGCATTATCCCCATCCCCCACAGTTTAGAGCCTTCTGCTTTTCTGGGGGTTTCA
GCCTATGAGACAAACTATAATCAGGCTTCATTATTACTTTTCAAATGGCCAAGGGTTATCTGCAATGTTGATCTAAAATCCTAAAAAATC
ACCCTGAAGTCAGGCAAGGAACAATACTTAAACTCCATACTATGGAAACAAGGTATCTAGCTGGATGCAGCTGGTAAATTCAGTCCCATG
GACCTTTGGGGGTTTATTTTCCTTAGCAGCTGACACCATGTGTCTTTTGCATCCCTGGTGGTGCTTGGTGCTTCTGCCCATCTGGGCTCA
TTGAGAATAGGGATGAAGATATGATTTTAGGGAATTTCTGATGGGCTGGCATGCCCCATGTAGTATGAGTTACTATATAAAGTCATGTGA
CTGGCATTTTAACAGACCTTCCAGAGCTTATATATCCCAATATATGTTGTTTCCTTTGAGTAGCCCCAGCAGGATACTGCTTAGTTTTTC
CAGTGCCATTGGTGAAAGCATTTCTGGAACTGTCTTCAAAGACTAGAAACACTGACTCCCAAAATGCTAGAACTGGAAGGGACCTTAATG
GTTATCTATTCCAGCCTCCTCCTAAGGTCCTCCTCAGCTTCTAGACCTAGAAGCCAAAGTCCAGAACAGTGACCCATTGATCAAGGCAGA
TAGTATAACTCCTTTTAAGTGTTCTCAGATTTGCCTTTTCTCAGGGCAAATCTTCAGTGTTTTGTGGTTATTTGTGGTTGAGAGAGAGAG
AGAATGTAATGTCTGAGACTAGCCAGCAGCTATTTGAAGCCTCTGGGAAAGAAGGTGGCTTATCAAGTGGGTTTGTAGTAATGAGTGCTG
CTGTAAAGCAGAGCCATTTTCTTGTGCAGCTCATAGTTCCCAAACAGTTCCCAAACAGAAATTCCAGAGATGTCTTAAACATTGTGGTCA
TCATTGAGATAGGTGGAATCTCTTTGGTGACTACGTTGGTGGGGAACATCACTCACCTGAATGTATGCATTCTGTGTTCTCTGTGTGTGT
GCACATATGCAGATGTATGTTTTAAAAACATTTACCAAACTCATGATTTTGTAGTCACACCACTTCAGTTCTGGGCCCTACCAACAATTT
ATGTCCTCCAAGAGCTGCTGGAGGGCATGTTTGTGCCCAAAACAGAAGAGCTGGCTCTGGTTTACAGAAGACAGGGAGGGTGACCTTACT
ATAAATGCCCTTAGAGGAAACTTATCAGTTACTGCCATTTCACGCATTTCCTTTTTGATCTTAGTAAATATTATTGGAAGGCTAGTCTTG
TTGGTAGGAGCAAAGACACTTATTTTTCCACTTGCCATCTTTCTCTATATCTCCAGTAATTTGAAAAACACTTTTCAGTTGGAATTGATT
TTTGTCTTTGGTAAAAAGAAATATTTTTAATAGATAAAAGATATATATTTTAAATATTTCCCCAAATTAATACTTTCATTTTAAGAATTG
CATAGCAGTTGTAACAAGTGCAGAATGAAGAACAAATTCTTGTTAAGCAAATAGTCCAAACTCTAGGTCCAGCTTACTGCCTTCCCCCCT
TGTACCTACAGTGATGCCTAGGATGGTATTGACAGTTGTTTTCTAAACTTCCTGCTGAGCAACAGTCCTTCAAATATAGGTAGAGTGGTC
TAGGTTAAGGAGGGAGGAGGGTTGATCTTTAATCAGGTTGGCTTTGGAGGAAGGAAAAACCACTAAGGTATTATCTGAATTTTAAGATGC
TTCCCATCCTTAATAACTAAAACCTGAATGCTTTTCTTTCTGAAAAATCTCCCTCTCTCCTTCCATGATTCTGAAGTTGGTTAAAAGTCG
ATATGTTGATGTGTATTATTTGGGGGAACAGAAAAGGACAAGGAAGGAAACAGAACGATGGGAAGGGTTTGTGAGCTAGAATAAGAGGTG
CAGGATTTCACAAAACAAATTCCTCACAAATCATTGAAGCCCAGTTCACCATACAAATTACCCATGTCTTACTCTGTTCCTTGTATATAT
GCATTCTGGGTTTTTTTATTATTAAAGGGGAAGTTAGGGGGGAGGGTGAAGGTCAGTCTGAGGGGAAATCCAGGAAATGTGGTGCCCTTA
GAAGGGGGCTGTCAGCTCTTTTCCATAGAGAGGGAAAGAAACTTTGAGAAAATGTTCTTGACCCATTGATTGTATCTGCTGGAAGAAGTC
ATCTGGGCCTGTTGGGTTGGTATCAGATCAGGGGATTATGCATCCAGCCCCTGGCCCCTTTAATCTATTTGCCTCTTTTTAAAAAAGGTT
AAGTCTTCTTGGGTGAGGCTTGCCAGGGAAACTCCTAAGTGGCTTCACTTATTTTTTAAATTTTAATTTAATTTTTAAATTTTTGCTTGG
AAGCAGCACTGGTAATAAATGTTTTATTTTTTGTTCATTTTCCCTAAAGGAAAAATGTCCTTAAGAGATTAAAGCTCTTAATTGATTACT
GTCTGGTTACAAACTGGCAAACTGACTAAAATGGGAAGCTGCCACCGTGCCTGACTCATGTAGCTGATGACCGAAGGCTCATCCTTTCTT
TTCTATTTGACAGACATTTACTGAGCTTCAGACTTGAGCCAACCCTGAGCTGGACTGTGGAGATAAAGCAGTTCCTGCTCTTGAGGAGCT
CAATGTCTAATGGAATGCATTTGAATGTATGTGTGGCTGGAGAGTTCATTTATGGTCTTAGGAAAGCCATTTCTGGTCCCATTTAGAAAA
CTGACCAGCACCCAGCAAGCTGCATTCTACATTTTAGAGACCCCATTGGTATTTGTGAATTTGATTGCACCACCGCTTTTCCTTTACTAA
GTAATGTTATGGAAGGAGAATGAATTTTCTCCTCTAGTGATTACAGGACATTAACATCTCTTCAGAAGCTGCTTTTAGCTTAAGCCCCAA
GAAGTGAGGTGGGTTGTGGATCACTGACATGGTCAGGGGAGGCCCACACCTCAATTCAGTAACCACCTAATCTCTCCCCCAACCTGATCT
CTCATCAGAGCTGGCAGCAACTTGGGATTCCTTTCCTTTTTCCTGCCTAACTTTTCATTGAAATGTCTAGTAGGAGAGTGAGAAAAGAGA
ACAAAGGCTGGGTCACAGTCATAGAATGTTACAGCTGGAATGGGCATGGAAATCATCCAAGTTAAACTTCTTCTCTGCCCCCCGCCCCCA
CTTTTTTTTTTTTTTTTTTTTAACCAAACGAACTTGTGATCCAGTGCCCTATTTTATAGTGTGGTTTTCCAGGGTCTGAATAAATAATCA
TTAAAGTTTGACACACGCAGACACACGCACCAATGATGGGGATACCCCCAAATGATTTAGGAGGTTATTTTATTTTAATAGTTTTTTCTT
CCTGATTTTTTTCAGTTAGTTAGAGTTAAATGTACCTATAGCCCCTGAATACATGCTCAGGTAGAGAAAGTCTCCATAGTATAAGTAAGT
AATATGAATGTGGAATCTTGGAAAGTGATATATTTTGATTGGAATAATTTTAATTAAATTTAATGATTTTAATTAAGAATTAAAAGCCAG
CTAGCCAAATTTTCTTTAAAAATTGGAAACTCATTATGGTCTTAAATTGTCCTCAGGCAGCCTTTTCCTCATCAACCCATAGAGTGGTCT
TTTGAACTGGTATCTAAACATACCTGGTTATGAATTCTCAAAAGAGAAAGCAGGTCTGGGGCGGGGTGGTCAGGAGACAGATTCTAGGGA
AAGTGCTGAAGAGATTTTCTTCTGAAGATGATCTAGGAAATGCATCTTTATACATGATTGTTAGCTGCTGTAGCTTTCTGAAGAAGATTG
TAGAAAAGAGACTAAGATATATGCAAGGGTCACCAGTTTAGAGATCAGTCAAATTGGAAAAAGTGCCAAGACTGGATGTGCAGATTGTTC
TATGTATTATCAGTATTTTTTTCCTCTTAAGAAAAAAATTTACTCTCTCTCCTTTGTGAGTAAATGCCTCCTTAATGCCTTTTAAGTAAG
GTGGCAACTTTTAACTGTCATCTTGTGAGAGGCAACCTCAAACTCTAAGCAGACTCCCTCTCTCCCTTTCTGGTGTCTTAAATCAAGAAC
TAGTTTGAAGCCAAGGCAAAGCAAGGTTTGTTCATCTTCCTTTCCTGTCATTTAAGGTAAAACAGGCAATGAACTCGCTCTTCAAATACC
ATAGTTCAAGAGTAGCTGTTGGCCCTGGTTCCAGATTAATATAGCAGCAGGCAGATTGCCCCTTCTTGGGGCCACCACCCTCCAAAGCTG
TGCCACCAATGAGAGCATTGGGTTCAAGTTTGCATCAAACATGGTATTACCAACGCTGAGCCTCCAGCAGAGCACTTAAAAGTCCTAGTG
AGAGAATAGATACTATGCAAGGGAAAAAAATTTAAATGCCAACGAATAGTTTTTTTTTTTTTGAACCTGATACACTGTTTGTTTACTCTC
AACTCTTTGTACAAATATTATTGTCCTAAGGGCCTTTTCCCCTCCTGCCTAGAAAATAGGTTGTGTATTGGTTTTATTCAACCTGCTGTC
TGCTTTAGGATTGGAGAAGGTACCTGGATCCTTGTGGACTGCCACTGCTGGCTGCCTCCTCTCCAACTCATCAGAAGAGCATTTTGACAA
AGACAGAGGACTTGGACCAGGGCATGCCCTGTTGGGGATGTTTCTGTCAGCAAGGACATGGCATGGAATCAAGTGGGCTGATGTGTTGTT
ATTTAAACAGTACCAAAGTGCATTCTTCAATGTATGTTTGCCTGCTTGAAGCAAGGCCCAAGTTGAGAATACAGTAAAGGAAACTCATGA

>In-frame_ENST00000409853_ENST00000299563_TCGA-BH-A201_FCHSD2_chr11_72613587_-_RNF169_chr11_74500670_length(amino acids)=519AA_start in transcript=954_stop in transcript=2513
MRKLREEKLQEEKPSEDQIHKLLPEDTETGKRKMDEQKKRDEPLVLKTNLERCPARLSDSENEEPSRGQMTQTHRSAFVSKNNSYSLAFL
AGKLNSKVERSQSCSDTAQERAKSRVRAVPGNKAKVTTMTPASNPIIGVLLSTQNNRCVSAPDLTIEKRLPFSSLSSLASLHKPERSVSP
ESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLNRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEM
GEELLGSEGIHSSKEKPLVAVNTRLSGGQVLSEYTGPTSADLDHFPSVSQTKAEQDSDNKSSTEIPLETCCSSELKGGGSGTSLEREQFE
GLGSTPDAKLDKTCISRAMKITTVNSVLPQNSVLGGVLKTKQQLKTLNHFDLTNGVLVESLSEEPLPSLRRGRKRHCKTKHLEQNGSLKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FCHSD2-RNF169


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FCHSD2-RNF169


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FCHSD2-RNF169


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFCHSD2C0087031Juvenile-Onset Still Disease1CTD_human
HgeneFCHSD2C3495559Juvenile arthritis1CTD_human
HgeneFCHSD2C3714758Juvenile psoriatic arthritis1CTD_human
HgeneFCHSD2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneFCHSD2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human