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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FCHSD2-TPCN2 (FusionGDB2 ID:29935)

Fusion Gene Summary for FCHSD2-TPCN2

check button Fusion gene summary
Fusion gene informationFusion gene name: FCHSD2-TPCN2
Fusion gene ID: 29935
HgeneTgene
Gene symbol

FCHSD2

TPCN2

Gene ID

9873

219931

Gene nameFCH and double SH3 domains 2two pore segment channel 2
SynonymsNWK|NWK1|SH3MD3SHEP10|TPC2
Cytomap

11q13.4

11q13.3

Type of geneprotein-codingprotein-coding
DescriptionF-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homologprotein nervous wreck 1two pore calcium channel protein 2voltage-dependent calcium channel protein TPC2
Modification date2020031320200320
UniProtAcc

O94868

.
Ensembl transtripts involved in fusion geneENST00000311172, ENST00000409314, 
ENST00000409418, ENST00000458644, 
ENST00000409853, ENST00000409263, 
ENST00000294309, ENST00000542467, 
ENST00000442692, 
Fusion gene scores* DoF score43 X 26 X 16=1788811 X 9 X 6=594
# samples 5912
** MAII scorelog2(59/17888*10)=-4.92213332859399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FCHSD2 [Title/Abstract] AND TPCN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFCHSD2(72613588)-TPCN2(68825046), # samples:3
Anticipated loss of major functional domain due to fusion event.FCHSD2-TPCN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FCHSD2-TPCN2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTPCN2

GO:0006874

cellular calcium ion homeostasis

19387438


check buttonFusion gene breakpoints across FCHSD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TPCN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A19W-06AFCHSD2chr11

72613588

-TPCN2chr11

68825046

+
ChimerDB4SKCMTCGA-ER-A19W-06AFCHSD2chr11

72613588

-TPCN2chr11

68825046

+
ChimerDB4SKCMTCGA-ER-A19W-06AFCHSD2chr11

72613588

-TPCN2chr11

68825046

+


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Fusion Gene ORF analysis for FCHSD2-TPCN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000311172ENST00000294309FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
In-frameENST00000311172ENST00000542467FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
5CDS-3UTRENST00000311172ENST00000442692FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
In-frameENST00000409314ENST00000294309FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
In-frameENST00000409314ENST00000542467FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
5CDS-3UTRENST00000409314ENST00000442692FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
In-frameENST00000409418ENST00000294309FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
In-frameENST00000409418ENST00000542467FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
5CDS-3UTRENST00000409418ENST00000442692FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
In-frameENST00000458644ENST00000294309FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
In-frameENST00000458644ENST00000542467FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
5CDS-3UTRENST00000458644ENST00000442692FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
Frame-shiftENST00000409853ENST00000294309FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
Frame-shiftENST00000409853ENST00000542467FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
5CDS-3UTRENST00000409853ENST00000442692FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
intron-3CDSENST00000409263ENST00000294309FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
intron-3CDSENST00000409263ENST00000542467FCHSD2chr11

72613588

-TPCN2chr11

68825046

+
intron-3UTRENST00000409263ENST00000442692FCHSD2chr11

72613588

-TPCN2chr11

68825046

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311172FCHSD2chr1172613588-ENST00000294309TPCN2chr1168825046+33969951252824899
ENST00000311172FCHSD2chr1172613588-ENST00000542467TPCN2chr1168825046+25299951252278717
ENST00000409314FCHSD2chr1172613588-ENST00000294309TPCN2chr1168825046+349410931692922917
ENST00000409314FCHSD2chr1172613588-ENST00000542467TPCN2chr1168825046+262710931692376735
ENST00000409418FCHSD2chr1172613588-ENST00000294309TPCN2chr1168825046+370913083843137917
ENST00000409418FCHSD2chr1172613588-ENST00000542467TPCN2chr1168825046+284213083842591735
ENST00000458644FCHSD2chr1172613588-ENST00000294309TPCN2chr1168825046+32168152902644784
ENST00000458644FCHSD2chr1172613588-ENST00000542467TPCN2chr1168825046+23498152902098602

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311172ENST00000294309FCHSD2chr1172613588-TPCN2chr1168825046+0.0020101650.9979899
ENST00000311172ENST00000542467FCHSD2chr1172613588-TPCN2chr1168825046+0.0036070070.996393
ENST00000409314ENST00000294309FCHSD2chr1172613588-TPCN2chr1168825046+0.0020665280.9979335
ENST00000409314ENST00000542467FCHSD2chr1172613588-TPCN2chr1168825046+0.0051280630.9948719
ENST00000409418ENST00000294309FCHSD2chr1172613588-TPCN2chr1168825046+0.0023975720.9976024
ENST00000409418ENST00000542467FCHSD2chr1172613588-TPCN2chr1168825046+0.0061946870.9938053
ENST00000458644ENST00000294309FCHSD2chr1172613588-TPCN2chr1168825046+0.0084795080.99152046
ENST00000458644ENST00000542467FCHSD2chr1172613588-TPCN2chr1168825046+0.0091075280.9908924

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Fusion Genomic Features for FCHSD2-TPCN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FCHSD2chr1172613587-TPCN2chr1168825045+1.58E-060.99999845
FCHSD2chr1172613587-TPCN2chr1168825045+1.58E-060.99999845

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FCHSD2-TPCN2


check button Go to

FGviewer for the breakpoints of chr11:72613588-chr11:68825046

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCHSD2

O94868

.
FUNCTION: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409418-10208_282308.0741.0DomainF-BAR
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325255_279143.0753.0IntramembraneHelical%3B Pore-forming
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325636_658143.0753.0IntramembraneHelical%3B Pore-forming
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325149_155143.0753.0Topological domainCytoplasmic
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325177_183143.0753.0Topological domainExtracellular
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325205_218143.0753.0Topological domainCytoplasmic
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325240_254143.0753.0Topological domainExtracellular
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325280_289143.0753.0Topological domainExtracellular
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325311_436143.0753.0Topological domainCytoplasmic
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325460_465143.0753.0Topological domainExtracellular
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325487_502143.0753.0Topological domainCytoplasmic
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325524_554143.0753.0Topological domainExtracellular
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325576_580143.0753.0Topological domainCytoplasmic
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325602_635143.0753.0Topological domainExtracellular
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325659_673143.0753.0Topological domainExtracellular
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325695_752143.0753.0Topological domainCytoplasmic
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325156_176143.0753.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325184_204143.0753.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325219_239143.0753.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325290_310143.0753.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325437_459143.0753.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325466_486143.0753.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325503_523143.0753.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325555_575143.0753.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325581_601143.0753.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325674_694143.0753.0TransmembraneHelical%3B Name%3DS6 of repeat II

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000311172-919356_397252.0685.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409418-1020356_397308.0741.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409853-1016356_397252.0516.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000311172-919718_721252.0685.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409418-1020718_721308.0741.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409853-1016718_721252.0516.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000311172-919469_530252.0685.0DomainSH3 1
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000311172-9198_282252.0685.0DomainF-BAR
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409418-1020469_530308.0741.0DomainSH3 1
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409853-1016469_530252.0516.0DomainSH3 1
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409853-10168_282252.0516.0DomainF-BAR
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000311172-919567_629252.0685.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409418-1020567_629308.0741.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72613588chr11:68825046ENST00000409853-1016567_629252.0516.0RegionRequired and sufficient for location at clathrin-coated pits
TgeneTPCN2chr11:72613588chr11:68825046ENST0000029430932517_20143.0753.0Compositional biasNote=Poly-Gly
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325106_127143.0753.0Topological domainExtracellular
TgeneTPCN2chr11:72613588chr11:68825046ENST000002943093251_84143.0753.0Topological domainCytoplasmic
TgeneTPCN2chr11:72613588chr11:68825046ENST00000294309325128_148143.0753.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneTPCN2chr11:72613588chr11:68825046ENST0000029430932585_105143.0753.0TransmembraneHelical%3B Name%3DS1 of repeat I


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Fusion Gene Sequence for FCHSD2-TPCN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000311172_ENST00000294309_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(transcript)=3396nt_BP=995nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGA
GAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGG
TAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAAC
TAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTG
AGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTAC
AGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGG
CAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGG
ATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGG
TGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTG
ATACTGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGGCTGCTGGGCTACCTCGTGGTGCTGGTGGTGTCTCTGGTGGACT
GGACCGTGTCCCTGAGTCTCGTGTGTCATGAGCCCCTGCGGATCCGCCGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTCCTCTATGA
TGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCCAGCGTCGGGCTGCTGCTGGCCATCCACCTGTGCCTCTTCACCA
TGTTCGGAATGCTGCTGTTCGCTGGTGGGAAGCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTC
TGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCT
TCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAAT
CTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCC
CTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGA
AGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACC
CGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCG
CCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTC
TCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCA
ACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGC
CGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCA
TGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACG
TATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGC
CCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGG
TGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGT
CTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTG
GGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGC
TGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAG
GTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAAC
CAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCT
GCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCC
GTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGT
GGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAG

>In-frame_ENST00000311172_ENST00000294309_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(amino acids)=899AA_start in transcript=125_stop in transcript=2824
MLTLPSGRIDVPSASCSRRRGRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENY
KNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRS
ECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQ
ENAVFHKPQPFQFQPCDSDTGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL
PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL
MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSA
EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE
MLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVL
GLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYR

--------------------------------------------------------------
>In-frame_ENST00000311172_ENST00000542467_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(transcript)=2529nt_BP=995nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGA
GAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGG
TAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAAC
TAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTG
AGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTAC
AGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGG
CAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGG
ATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGG
TGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTG
ATACTGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGGCTGCTGGGCTACCTCGTGGTGCTGGTGGTGTCTCTGGTGGACT
GGACCGTGTCCCTGAGTCTCGTGTGTCATGAGCCCCTGCGGATCCGCCGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTCCTCTATGA
TGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCCAGCGTCGGGCTGCTGCTGGCCATCCACCTGTGCCTCTTCACCA
TGTTCGGAATGCTGCTGTTCGCTGGTGGGAAGCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTC
TGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCT
TCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAAT
CTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCC
CTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGA
AGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACC
CGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCG
CCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTC
TCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCA
ACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCC
CAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCC
AGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCC
GTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTC
CTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCA

>In-frame_ENST00000311172_ENST00000542467_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(amino acids)=717AA_start in transcript=125_stop in transcript=2278
MLTLPSGRIDVPSASCSRRRGRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENY
KNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRS
ECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQ
ENAVFHKPQPFQFQPCDSDTGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSL
PEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFL
MNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSA
EEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLE

--------------------------------------------------------------
>In-frame_ENST00000409314_ENST00000294309_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(transcript)=3494nt_BP=1093nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGA
TTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATA
CCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAAC
AATGCAGGTAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGA
ACAGCAACTAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAA
ATACTTTGAGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAAT
CAGTTTACAGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTAC
CCTAGCGGCAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCA
TCTCAAGGATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTC
CAGCAAGGTGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTG
TGACAGTGATACTGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGGCTGCTGGGCTACCTCGTGGTGCTGGTGGTGTCTCT
GGTGGACTGGACCGTGTCCCTGAGTCTCGTGTGTCATGAGCCCCTGCGGATCCGCCGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTC
CTCTATGATGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCCAGCGTCGGGCTGCTGCTGGCCATCCACCTGTGCCT
CTTCACCATGTTCGGAATGCTGCTGTTCGCTGGTGGGAAGCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCC
TGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGC
CATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCT
GATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGG
AGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCAT
GATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAA
AGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAA
CCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCT
GGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTA
CCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGG
CTGGAGGCCGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCAT
CCCCAGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGT
CTACTACGTATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGG
CTCGGCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTT
GATGGTGGTGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCT
GGTGTCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCC
CCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCAC
AGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGC
CTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGG
ACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTT
TTATAGCTGCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTG
CAGCTTCCGTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGC
ATTCAGGTGGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGT

>In-frame_ENST00000409314_ENST00000294309_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(amino acids)=917AA_start in transcript=169_stop in transcript=2922
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFL
LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN
RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSH
KQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD
DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF
LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT
LWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGE

--------------------------------------------------------------
>In-frame_ENST00000409314_ENST00000542467_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(transcript)=2627nt_BP=1093nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGA
TTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATA
CCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAAC
AATGCAGGTAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGA
ACAGCAACTAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAA
ATACTTTGAGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAAT
CAGTTTACAGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTAC
CCTAGCGGCAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCA
TCTCAAGGATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTC
CAGCAAGGTGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTG
TGACAGTGATACTGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGGCTGCTGGGCTACCTCGTGGTGCTGGTGGTGTCTCT
GGTGGACTGGACCGTGTCCCTGAGTCTCGTGTGTCATGAGCCCCTGCGGATCCGCCGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTC
CTCTATGATGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCCAGCGTCGGGCTGCTGCTGGCCATCCACCTGTGCCT
CTTCACCATGTTCGGAATGCTGCTGTTCGCTGGTGGGAAGCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCC
TGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGC
CATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCT
GATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGG
AGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCAT
GATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAA
AGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAA
CCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCT
GGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTA
CCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGC
TGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAG
GCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACAC
AGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGA
ACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAG

>In-frame_ENST00000409314_ENST00000542467_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(amino acids)=735AA_start in transcript=169_stop in transcript=2376
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFL
LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN
RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSH
KQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD
DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDE

--------------------------------------------------------------
>In-frame_ENST00000409418_ENST00000294309_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(transcript)=3709nt_BP=1308nt
GGCGGCGCAGGCGGCCGACCGGGAGCGCGGACAACGCGGCTGCGGCTAACCCGCCGCCCGGCCGGCTGAGACCCTCGCGCCCCTGCTCCT
GGGGCCCCCGCCCCCTCGCCGTCTCCGCCTCCTTCCTCACACACCCCCGGGCCGCCCGGGCCGCCCGGGCCCCAAGCCTTCCCGGTGCTC
CTCCCTCGTCTCCTCACACTCGCTCTCTGGCTGGGGTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGC
GCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGTCCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGG
GAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATG
ACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAG
TATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGC
ATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATT
TCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAA
GAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAG
GCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCC
AAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAAC
ATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCT
GTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGGTGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTA
TTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTGATACTGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGG
CTGCTGGGCTACCTCGTGGTGCTGGTGGTGTCTCTGGTGGACTGGACCGTGTCCCTGAGTCTCGTGTGTCATGAGCCCCTGCGGATCCGC
CGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTCCTCTATGATGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCC
AGCGTCGGGCTGCTGCTGGCCATCCACCTGTGCCTCTTCACCATGTTCGGAATGCTGCTGTTCGCTGGTGGGAAGCAGGATGATGGGCAG
GACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTG
ATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTG
ACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCC
TTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAG
AAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAG
AAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTC
CTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCA
GATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAG
GTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATC
TCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTG
AACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAG
AACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCT
CTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGAT
GACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGC
CCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTC
CTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGG
GATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGC
CGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGA
AGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTG
GTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACA
AAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCCGTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCA
GGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGTGGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTAT
TATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAGGGTTCTGATTGCCAGTTATTTTCATCAATAAGTCTTGCAAAGAATGG

>In-frame_ENST00000409418_ENST00000294309_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(amino acids)=917AA_start in transcript=384_stop in transcript=3137
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFL
LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN
RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSH
KQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD
DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRF
LRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVT
LWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGE

--------------------------------------------------------------
>In-frame_ENST00000409418_ENST00000542467_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(transcript)=2842nt_BP=1308nt
GGCGGCGCAGGCGGCCGACCGGGAGCGCGGACAACGCGGCTGCGGCTAACCCGCCGCCCGGCCGGCTGAGACCCTCGCGCCCCTGCTCCT
GGGGCCCCCGCCCCCTCGCCGTCTCCGCCTCCTTCCTCACACACCCCCGGGCCGCCCGGGCCGCCCGGGCCCCAAGCCTTCCCGGTGCTC
CTCCCTCGTCTCCTCACACTCGCTCTCTGGCTGGGGTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGC
GCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGTCCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGG
GAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATG
ACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAG
TATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGC
ATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATT
TCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAA
GAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAG
GCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCC
AAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAAC
ATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCT
GTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGGTGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTA
TTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTGATACTGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGG
CTGCTGGGCTACCTCGTGGTGCTGGTGGTGTCTCTGGTGGACTGGACCGTGTCCCTGAGTCTCGTGTGTCATGAGCCCCTGCGGATCCGC
CGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTCCTCTATGATGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCC
AGCGTCGGGCTGCTGCTGGCCATCCACCTGTGCCTCTTCACCATGTTCGGAATGCTGCTGTTCGCTGGTGGGAAGCAGGATGATGGGCAG
GACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTG
ATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTG
ACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCC
TTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAG
AAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAG
AAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTC
CTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCA
GATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAG
GTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCAC
AAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATT
CTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCC
AGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGAC
CTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTT

>In-frame_ENST00000409418_ENST00000542467_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(amino acids)=735AA_start in transcript=384_stop in transcript=2591
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFL
LQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKN
RAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSH
KQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERD
DFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDE

--------------------------------------------------------------
>In-frame_ENST00000458644_ENST00000294309_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(transcript)=3216nt_BP=815nt
GCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAA
GTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCT
ATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAAT
GATTACAGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTG
AGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTAC
AGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGG
CAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGG
ATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGG
TGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTG
ATACTGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGGCTGCTGGGCTACCTCGTGGTGCTGGTGGTGTCTCTGGTGGACT
GGACCGTGTCCCTGAGTCTCGTGTGTCATGAGCCCCTGCGGATCCGCCGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTCCTCTATGA
TGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCCAGCGTCGGGCTGCTGCTGGCCATCCACCTGTGCCTCTTCACCA
TGTTCGGAATGCTGCTGTTCGCTGGTGGGAAGCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTC
TGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCT
TCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAAT
CTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCC
CTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGA
AGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACC
CGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCG
CCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTC
TCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCA
ACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGC
CGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCA
TGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACG
TATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGC
CCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGG
TGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGT
CTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTG
GGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGC
TGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAG
GTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAAC
CAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCT
GCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCC
GTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGT
GGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAG

>In-frame_ENST00000458644_ENST00000294309_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(amino acids)=784AA_start in transcript=290_stop in transcript=2644
MTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQD
RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTGYLFG
WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF
AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLF
RRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ
SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLL
TVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGI
NLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNL

--------------------------------------------------------------
>In-frame_ENST00000458644_ENST00000542467_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(transcript)=2349nt_BP=815nt
GCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAA
GTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCT
ATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAAT
GATTACAGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTG
AGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTAC
AGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGG
CAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGG
ATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGG
TGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTG
ATACTGGTTACCTGTTCGGGTGGGCCCATTTCCAGAAAAACCTTTGGCTGCTGGGCTACCTCGTGGTGCTGGTGGTGTCTCTGGTGGACT
GGACCGTGTCCCTGAGTCTCGTGTGTCATGAGCCCCTGCGGATCCGCCGGCTTCTCCGTCCCTTCTTCCTGCTGCAGAACTCCTCTATGA
TGAAGAAGACCTTGAAATGCATCCGCTGGTCGCTGCCGGAAATGGCCAGCGTCGGGCTGCTGCTGGCCATCCACCTGTGCCTCTTCACCA
TGTTCGGAATGCTGCTGTTCGCTGGTGGGAAGCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTC
TGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCT
TCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAAT
CTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCC
CTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGA
AGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACC
CGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCG
CCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTC
TCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCA
ACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCC
CAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCC
AGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCC
GTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTC
CTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCA

>In-frame_ENST00000458644_ENST00000542467_TCGA-ER-A19W-06A_FCHSD2_chr11_72613588_-_TPCN2_chr11_68825046_length(amino acids)=602AA_start in transcript=290_stop in transcript=2098
MTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQD
RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTGYLFG
WAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLF
AGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLF
RRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQ
SPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FCHSD2-TPCN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FCHSD2-TPCN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FCHSD2-TPCN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFCHSD2C0087031Juvenile-Onset Still Disease1CTD_human
HgeneFCHSD2C3495559Juvenile arthritis1CTD_human
HgeneFCHSD2C3714758Juvenile psoriatic arthritis1CTD_human
HgeneFCHSD2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneFCHSD2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human