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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FCRL1-KATNA1 (FusionGDB2 ID:29947)

Fusion Gene Summary for FCRL1-KATNA1

check button Fusion gene summary
Fusion gene informationFusion gene name: FCRL1-KATNA1
Fusion gene ID: 29947
HgeneTgene
Gene symbol

FCRL1

KATNA1

Gene ID

115350

11104

Gene nameFc receptor like 1katanin catalytic subunit A1
SynonymsCD307a|FCRH1|IFGP1|IRTA5-
Cytomap

1q23.1

6q25.1

Type of geneprotein-codingprotein-coding
DescriptionFc receptor-like protein 1IFGP family protein 1fc receptor homolog 1fcR-like protein 1hIFGP1immune receptor translocation-associated protein 5immunoglobulin superfamily Fc receptor, gp42katanin p60 ATPase-containing subunit A1katanin p60 (ATPase containing) subunit A 1katanin p60 subunit A1p60 katanin
Modification date2020032020200315
UniProtAcc

Q96LA6

O75449

Ensembl transtripts involved in fusion geneENST00000489998, ENST00000358292, 
ENST00000368176, ENST00000491942, 
ENST00000335647, ENST00000335643, 
ENST00000367411, ENST00000494504, 
Fusion gene scores* DoF score3 X 3 X 1=95 X 6 X 4=120
# samples 35
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FCRL1 [Title/Abstract] AND KATNA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFCRL1(157789797)-KATNA1(149925919), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFCRL1

GO:0042113

B cell activation

15479727


check buttonFusion gene breakpoints across FCRL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KATNA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA283968FCRL1chr1

157789797

-KATNA1chr6

149925919

-


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Fusion Gene ORF analysis for FCRL1-KATNA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000489998ENST00000335647FCRL1chr1

157789797

-KATNA1chr6

149925919

-
intron-intronENST00000489998ENST00000335643FCRL1chr1

157789797

-KATNA1chr6

149925919

-
intron-intronENST00000489998ENST00000367411FCRL1chr1

157789797

-KATNA1chr6

149925919

-
intron-5UTRENST00000489998ENST00000494504FCRL1chr1

157789797

-KATNA1chr6

149925919

-
In-frameENST00000358292ENST00000335647FCRL1chr1

157789797

-KATNA1chr6

149925919

-
5CDS-intronENST00000358292ENST00000335643FCRL1chr1

157789797

-KATNA1chr6

149925919

-
5CDS-intronENST00000358292ENST00000367411FCRL1chr1

157789797

-KATNA1chr6

149925919

-
5CDS-5UTRENST00000358292ENST00000494504FCRL1chr1

157789797

-KATNA1chr6

149925919

-
In-frameENST00000368176ENST00000335647FCRL1chr1

157789797

-KATNA1chr6

149925919

-
5CDS-intronENST00000368176ENST00000335643FCRL1chr1

157789797

-KATNA1chr6

149925919

-
5CDS-intronENST00000368176ENST00000367411FCRL1chr1

157789797

-KATNA1chr6

149925919

-
5CDS-5UTRENST00000368176ENST00000494504FCRL1chr1

157789797

-KATNA1chr6

149925919

-
In-frameENST00000491942ENST00000335647FCRL1chr1

157789797

-KATNA1chr6

149925919

-
5CDS-intronENST00000491942ENST00000335643FCRL1chr1

157789797

-KATNA1chr6

149925919

-
5CDS-intronENST00000491942ENST00000367411FCRL1chr1

157789797

-KATNA1chr6

149925919

-
5CDS-5UTRENST00000491942ENST00000494504FCRL1chr1

157789797

-KATNA1chr6

149925919

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358292FCRL1chr1157789797-ENST00000335647KATNA1chr6149925919-1221831641057297
ENST00000368176FCRL1chr1157789797-ENST00000335647KATNA1chr6149925919-1237991801073297
ENST00000491942FCRL1chr1157789797-ENST00000335647KATNA1chr6149925919-1192541351028297

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358292ENST00000335647FCRL1chr1157789797-KATNA1chr6149925919-0.0014003210.9985997
ENST00000368176ENST00000335647FCRL1chr1157789797-KATNA1chr6149925919-0.0014431610.9985568
ENST00000491942ENST00000335647FCRL1chr1157789797-KATNA1chr6149925919-0.0013861370.99861383

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Fusion Genomic Features for FCRL1-KATNA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FCRL1-KATNA1


check button Go to

FGviewer for the breakpoints of chr1:157789797-chr6:149925919

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCRL1

Q96LA6

KATNA1

O75449

FUNCTION: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. {ECO:0000269|PubMed:15479727}.FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKATNA1chr1:157789797chr6:149925919ENST0000033564308249_2560312.0Nucleotide bindingATP
TgeneKATNA1chr1:157789797chr6:149925919ENST00000335647210249_256167.0492.0Nucleotide bindingATP
TgeneKATNA1chr1:157789797chr6:149925919ENST00000367411311249_256167.0492.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110109_20010.333333333333334367.0DomainNote=Ig-like C2-type 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-11017_10410.333333333333334367.0DomainNote=Ig-like C2-type 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110208_29110.333333333333334367.0DomainNote=Ig-like C2-type 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111109_20010.333333333333334430.0DomainNote=Ig-like C2-type 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-11117_10410.333333333333334430.0DomainNote=Ig-like C2-type 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111208_29110.333333333333334430.0DomainNote=Ig-like C2-type 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111109_20010.333333333333334429.0DomainNote=Ig-like C2-type 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-11117_10410.333333333333334429.0DomainNote=Ig-like C2-type 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111208_29110.333333333333334429.0DomainNote=Ig-like C2-type 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110354_35910.333333333333334367.0MotifNote=ITIM motif 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110367_37210.333333333333334367.0MotifNote=ITIM motif 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110379_38410.333333333333334367.0MotifNote=ITIM motif 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110410_41510.333333333333334367.0MotifNote=ITIM motif 4
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110423_42810.333333333333334367.0MotifNote=ITIM motif 5
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111354_35910.333333333333334430.0MotifNote=ITIM motif 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111367_37210.333333333333334430.0MotifNote=ITIM motif 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111379_38410.333333333333334430.0MotifNote=ITIM motif 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111410_41510.333333333333334430.0MotifNote=ITIM motif 4
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111423_42810.333333333333334430.0MotifNote=ITIM motif 5
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111354_35910.333333333333334429.0MotifNote=ITIM motif 1
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111367_37210.333333333333334429.0MotifNote=ITIM motif 2
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111379_38410.333333333333334429.0MotifNote=ITIM motif 3
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111410_41510.333333333333334429.0MotifNote=ITIM motif 4
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111423_42810.333333333333334429.0MotifNote=ITIM motif 5
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-11017_30710.333333333333334367.0Topological domainExtracellular
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110329_42910.333333333333334367.0Topological domainCytoplasmic
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-11117_30710.333333333333334430.0Topological domainExtracellular
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111329_42910.333333333333334430.0Topological domainCytoplasmic
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-11117_30710.333333333333334429.0Topological domainExtracellular
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111329_42910.333333333333334429.0Topological domainCytoplasmic
HgeneFCRL1chr1:157789797chr6:149925919ENST00000358292-110308_32810.333333333333334367.0TransmembraneHelical
HgeneFCRL1chr1:157789797chr6:149925919ENST00000368176-111308_32810.333333333333334430.0TransmembraneHelical
HgeneFCRL1chr1:157789797chr6:149925919ENST00000491942-111308_32810.333333333333334429.0TransmembraneHelical


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Fusion Gene Sequence for FCRL1-KATNA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000358292_ENST00000335647_AA283968_FCRL1_chr1_157789797_-_KATNA1_chr6_149925919_length(transcript)=1221nt_BP=83nt
ATTCTTTTTTTGATGAGAGGCATCTCTAGGTACCATCCCTGACCTGGTCCTCATGCTGCCGAGGCTGTTGCTGTTGATCTGTGAACAAAT
CACCTGCTGCAGTAACAGAACCAGAGACAAATAAATTTGATAGTACCGGATATGATAAAGACTTAGTAGAAGCTTTGGAAAGAGATATAA
TTTCCCAGAATCCCAATGTTCGATGGGATGATATCGCTGATTTAGTAGAAGCTAAAAAGTTGCTTAAGGAAGCCGTAGTGTTACCAATGT
GGATGCCCGAATTCTTTAAGGGCATTAGGAGACCATGGAAAGGAGTACTGATGGTCGGCCCACCTGGCACGGGGAAGACGCTCCTTGCTA
AAGCAGTAGCTACAGAATGCAAGACAACATTCTTCAATGTCTCTTCATCAACTTTGACTTCCAAATACAGAGGAGAATCTGAGAAGCTTG
TTCGTCTTCTGTTTGAAATGGCTCGATTTTATTCTCCAGCCACCATATTTATTGATGAGATAGACTCCATCTGTAGTCGCCGAGGGACTT
CTGAAGAACATGAAGCAAGCAGAAGGGTGAAAGCGGAGCTGCTGGTTCAGATGGATGGTGTTGGAGGTACTTCTGAAAATGATGACCCTT
CCAAAATGGTTATGGTTCTGGCAGCTACTAATTTTCCCTGGGATATAGATGAGGCTTTAAGACGACGCCTTGAGAAACGAATCTATATTC
CTTTGCCGTCAGCAAAAGGCAGGGAGGAGCTATTACGAATAAGTCTACGTGAGTTGGAATTGGCTGATGATGTTGACCTTGCAAGTATAG
CAGAAAACATGGAAGGTTATTCAGGTGCGGACATTACCAACGTGTGCAGGGATGCGTCCTTGATGGCAATGAGAAGGCGCATTGAAGGTT
TGACTCCAGAGGAAATCCGAAATCTTTCCAAAGAAGAAATGCACATGCCTACAACTATGGAGGATTTCGAGATGGCTTTAAAAAAGGTTT
CTAAGTCAGTGTCTGCTGCAGACATTGAAAGATACGAGAAATGGATATTTGAGTTTGGATCATGCTAAATTCTCACATGTAAACTGTGAG
AAATGTGCCTTAAGTGTTTGAATATTAAATGCAGTAATTCATTGTACTGAGTGCTATATTTTTTTTAACTTTCATAATGGTAAGATTTTT

>In-frame_ENST00000358292_ENST00000335647_AA283968_FCRL1_chr1_157789797_-_KATNA1_chr6_149925919_length(amino acids)=297AA_start in transcript=164_stop in transcript=1057
MERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRG
ESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLE
KRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEM

--------------------------------------------------------------
>In-frame_ENST00000368176_ENST00000335647_AA283968_FCRL1_chr1_157789797_-_KATNA1_chr6_149925919_length(transcript)=1237nt_BP=99nt
CTCGACTCTGAGGTGCATTCTTTTTTTGATGAGAGGCATCTCTAGGTACCATCCCTGACCTGGTCCTCATGCTGCCGAGGCTGTTGCTGT
TGATCTGTGAACAAATCACCTGCTGCAGTAACAGAACCAGAGACAAATAAATTTGATAGTACCGGATATGATAAAGACTTAGTAGAAGCT
TTGGAAAGAGATATAATTTCCCAGAATCCCAATGTTCGATGGGATGATATCGCTGATTTAGTAGAAGCTAAAAAGTTGCTTAAGGAAGCC
GTAGTGTTACCAATGTGGATGCCCGAATTCTTTAAGGGCATTAGGAGACCATGGAAAGGAGTACTGATGGTCGGCCCACCTGGCACGGGG
AAGACGCTCCTTGCTAAAGCAGTAGCTACAGAATGCAAGACAACATTCTTCAATGTCTCTTCATCAACTTTGACTTCCAAATACAGAGGA
GAATCTGAGAAGCTTGTTCGTCTTCTGTTTGAAATGGCTCGATTTTATTCTCCAGCCACCATATTTATTGATGAGATAGACTCCATCTGT
AGTCGCCGAGGGACTTCTGAAGAACATGAAGCAAGCAGAAGGGTGAAAGCGGAGCTGCTGGTTCAGATGGATGGTGTTGGAGGTACTTCT
GAAAATGATGACCCTTCCAAAATGGTTATGGTTCTGGCAGCTACTAATTTTCCCTGGGATATAGATGAGGCTTTAAGACGACGCCTTGAG
AAACGAATCTATATTCCTTTGCCGTCAGCAAAAGGCAGGGAGGAGCTATTACGAATAAGTCTACGTGAGTTGGAATTGGCTGATGATGTT
GACCTTGCAAGTATAGCAGAAAACATGGAAGGTTATTCAGGTGCGGACATTACCAACGTGTGCAGGGATGCGTCCTTGATGGCAATGAGA
AGGCGCATTGAAGGTTTGACTCCAGAGGAAATCCGAAATCTTTCCAAAGAAGAAATGCACATGCCTACAACTATGGAGGATTTCGAGATG
GCTTTAAAAAAGGTTTCTAAGTCAGTGTCTGCTGCAGACATTGAAAGATACGAGAAATGGATATTTGAGTTTGGATCATGCTAAATTCTC
ACATGTAAACTGTGAGAAATGTGCCTTAAGTGTTTGAATATTAAATGCAGTAATTCATTGTACTGAGTGCTATATTTTTTTTAACTTTCA

>In-frame_ENST00000368176_ENST00000335647_AA283968_FCRL1_chr1_157789797_-_KATNA1_chr6_149925919_length(amino acids)=297AA_start in transcript=180_stop in transcript=1073
MERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRG
ESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLE
KRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEM

--------------------------------------------------------------
>In-frame_ENST00000491942_ENST00000335647_AA283968_FCRL1_chr1_157789797_-_KATNA1_chr6_149925919_length(transcript)=1192nt_BP=54nt
GTACCATCCCTGACCTGGTCCTCATGCTGCCGAGGCTGTTGCTGTTGATCTGTGAACAAATCACCTGCTGCAGTAACAGAACCAGAGACA
AATAAATTTGATAGTACCGGATATGATAAAGACTTAGTAGAAGCTTTGGAAAGAGATATAATTTCCCAGAATCCCAATGTTCGATGGGAT
GATATCGCTGATTTAGTAGAAGCTAAAAAGTTGCTTAAGGAAGCCGTAGTGTTACCAATGTGGATGCCCGAATTCTTTAAGGGCATTAGG
AGACCATGGAAAGGAGTACTGATGGTCGGCCCACCTGGCACGGGGAAGACGCTCCTTGCTAAAGCAGTAGCTACAGAATGCAAGACAACA
TTCTTCAATGTCTCTTCATCAACTTTGACTTCCAAATACAGAGGAGAATCTGAGAAGCTTGTTCGTCTTCTGTTTGAAATGGCTCGATTT
TATTCTCCAGCCACCATATTTATTGATGAGATAGACTCCATCTGTAGTCGCCGAGGGACTTCTGAAGAACATGAAGCAAGCAGAAGGGTG
AAAGCGGAGCTGCTGGTTCAGATGGATGGTGTTGGAGGTACTTCTGAAAATGATGACCCTTCCAAAATGGTTATGGTTCTGGCAGCTACT
AATTTTCCCTGGGATATAGATGAGGCTTTAAGACGACGCCTTGAGAAACGAATCTATATTCCTTTGCCGTCAGCAAAAGGCAGGGAGGAG
CTATTACGAATAAGTCTACGTGAGTTGGAATTGGCTGATGATGTTGACCTTGCAAGTATAGCAGAAAACATGGAAGGTTATTCAGGTGCG
GACATTACCAACGTGTGCAGGGATGCGTCCTTGATGGCAATGAGAAGGCGCATTGAAGGTTTGACTCCAGAGGAAATCCGAAATCTTTCC
AAAGAAGAAATGCACATGCCTACAACTATGGAGGATTTCGAGATGGCTTTAAAAAAGGTTTCTAAGTCAGTGTCTGCTGCAGACATTGAA
AGATACGAGAAATGGATATTTGAGTTTGGATCATGCTAAATTCTCACATGTAAACTGTGAGAAATGTGCCTTAAGTGTTTGAATATTAAA
TGCAGTAATTCATTGTACTGAGTGCTATATTTTTTTTAACTTTCATAATGGTAAGATTTTTTTAAAAAAACCCTTATGATTCTGAATAAA

>In-frame_ENST00000491942_ENST00000335647_AA283968_FCRL1_chr1_157789797_-_KATNA1_chr6_149925919_length(amino acids)=297AA_start in transcript=135_stop in transcript=1028
MERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRG
ESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLE
KRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FCRL1-KATNA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneKATNA1chr1:157789797chr6:149925919ENST00000335643081_750312.0dynein and NDEL1
TgeneKATNA1chr1:157789797chr6:149925919ENST00000335643081_290312.0KATNB1
TgeneKATNA1chr1:157789797chr6:149925919ENST00000335643081_1850312.0microtubules


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneKATNA1chr1:157789797chr6:149925919ENST000003356472101_75167.0492.0dynein and NDEL1
TgeneKATNA1chr1:157789797chr6:149925919ENST000003674113111_75167.0492.0dynein and NDEL1
TgeneKATNA1chr1:157789797chr6:149925919ENST000003356472101_29167.0492.0KATNB1
TgeneKATNA1chr1:157789797chr6:149925919ENST000003674113111_29167.0492.0KATNB1
TgeneKATNA1chr1:157789797chr6:149925919ENST000003356472101_185167.0492.0microtubules
TgeneKATNA1chr1:157789797chr6:149925919ENST000003674113111_185167.0492.0microtubules


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FCRL1-KATNA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FCRL1-KATNA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource