FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:FGF13-NLRP3 (FusionGDB2 ID:30135)

Fusion Gene Summary for FGF13-NLRP3

check button Fusion gene summary
Fusion gene informationFusion gene name: FGF13-NLRP3
Fusion gene ID: 30135
HgeneTgene
Gene symbol

FGF13

NLRP3

Gene ID

2258

114548

Gene namefibroblast growth factor 13NLR family pyrin domain containing 3
SynonymsFGF-13|FGF2|FHF-2|FHF2|LINC00889AGTAVPRL|AII|AVP|C1orf7|CIAS1|CLR1.1|DFNA34|FCAS|FCAS1|FCU|KEFH|MWS|NALP3|PYPAF1
Cytomap

Xq26.3-q27.1

1q44

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor 13fibroblast growth factor homologous factor 2NACHT, LRR and PYD domains-containing protein 3NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3NACHT, LRR and PYD containing protein 3PYRIN-containing APAF1-like protein 1caterpiller protein 1.1cold autoinflammatory syndrome 1 protei
Modification date2020031320200315
UniProtAcc

Q92913

Q96P20

Ensembl transtripts involved in fusion geneENST00000315930, ENST00000305414, 
ENST00000441825, ENST00000370603, 
ENST00000541469, 		ENST00000366497, 
ENST00000391828, ENST00000336119, 
ENST00000348069, ENST00000366496, 
ENST00000391827, ENST00000474792, 
Fusion gene scores* DoF score10 X 5 X 4=2002 X 2 X 2=8
# samples 92
** MAII scorelog2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: FGF13 [Title/Abstract] AND NLRP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGF13(137939674)-NLRP3(247611707), # samples:3
Anticipated loss of major functional domain due to fusion event.FGF13-NLRP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FGF13-NLRP3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGF13

GO:0000165

MAPK cascade

12244047

TgeneNLRP3

GO:0032088

negative regulation of NF-kappaB transcription factor activity

14662828

TgeneNLRP3

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

15030775

TgeneNLRP3

GO:0050718

positive regulation of interleukin-1 beta secretion

15030775

TgeneNLRP3

GO:0051092

positive regulation of NF-kappaB transcription factor activity

19158675

TgeneNLRP3

GO:0071222

cellular response to lipopolysaccharide

28847925

TgeneNLRP3

GO:1901223

negative regulation of NIK/NF-kappaB signaling

14662828


check buttonFusion gene breakpoints across FGF13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NLRP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04U-01AFGF13chrX

137939674

-NLRP3chr1

247611707

+
ChimerDB4BRCATCGA-A2-A04U-01AFGF13chrX

137939674

-NLRP3chr1

247611707

+
ChimerDB4BRCATCGA-A2-A04U-01AFGF13chrX

137939674

-NLRP3chr1

247611707

+


Top

Fusion Gene ORF analysis for FGF13-NLRP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000315930ENST00000366497FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000315930ENST00000391828FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000315930ENST00000336119FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000315930ENST00000348069FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000315930ENST00000366496FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000315930ENST00000391827FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-intronENST00000315930ENST00000474792FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000305414ENST00000366497FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000305414ENST00000391828FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000305414ENST00000336119FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000305414ENST00000348069FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000305414ENST00000366496FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000305414ENST00000391827FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-intronENST00000305414ENST00000474792FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000441825ENST00000366497FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000441825ENST00000391828FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000441825ENST00000336119FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000441825ENST00000348069FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000441825ENST00000366496FGF13chrX

137939674

-NLRP3chr1

247611707

+
In-frameENST00000441825ENST00000391827FGF13chrX

137939674

-NLRP3chr1

247611707

+
5CDS-intronENST00000441825ENST00000474792FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000370603ENST00000366497FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000370603ENST00000391828FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000370603ENST00000336119FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000370603ENST00000348069FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000370603ENST00000366496FGF13chrX

137939674

-NLRP3chr1

247611707

+
Frame-shiftENST00000370603ENST00000391827FGF13chrX

137939674

-NLRP3chr1

247611707

+
5CDS-intronENST00000370603ENST00000474792FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000541469ENST00000366497FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000541469ENST00000391828FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000541469ENST00000336119FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000541469ENST00000348069FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000541469ENST00000366496FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-3CDSENST00000541469ENST00000391827FGF13chrX

137939674

-NLRP3chr1

247611707

+
intron-intronENST00000541469ENST00000474792FGF13chrX

137939674

-NLRP3chr1

247611707

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441825FGF13chrX137939674-ENST00000391827NLRP3chr1247611707+268168221169

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441825ENST00000391827FGF13chrX137939674-NLRP3chr1247611707+0.872201560.12779847

Top

Fusion Genomic Features for FGF13-NLRP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FGF13chrX137939673-NLRP3chr1247611706+0.0001307520.9998692
FGF13chrX137939673-NLRP3chr1247611706+0.0001307520.9998692

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FGF13-NLRP3


check button Go to

FGviewer for the breakpoints of chrX:137939674-chr1:247611707

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGF13

Q92913

NLRP3

Q96P20

FUNCTION: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (PubMed:15282281). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity). {ECO:0000250|UniProtKB:P70377, ECO:0000269|PubMed:15282281}.FUNCTION: As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33 (PubMed:23871209). Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). {ECO:0000250|UniProtKB:Q8R4B8, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:28847925, ECO:0000305|PubMed:23305783}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957913_933889.6666666666666923.0RepeatNote=LRR 7
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957942_963889.6666666666666923.0RepeatNote=LRR 8
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957970_991889.6666666666666923.0RepeatNote=LRR 9
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668970_991946.6666666666666980.0RepeatNote=LRR 9
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779970_991946.6666666666666980.0RepeatNote=LRR 9
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768970_991946.6666666666666980.0RepeatNote=LRR 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979690_6971003.66666666666661037.0Compositional biasNote=Poly-Glu
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957690_697889.6666666666666923.0Compositional biasNote=Poly-Glu
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668690_697946.6666666666666980.0Compositional biasNote=Poly-Glu
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779690_697946.6666666666666980.0Compositional biasNote=Poly-Glu
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768690_697946.6666666666666980.0Compositional biasNote=Poly-Glu
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911690_6971003.66666666666661037.0Compositional biasNote=Poly-Glu
TgeneNLRP3chrX:137939674chr1:247611707ENST00000336119791_931003.66666666666661037.0DomainPyrin
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979220_5361003.66666666666661037.0DomainNACHT
TgeneNLRP3chrX:137939674chr1:247611707ENST00000348069571_93889.6666666666666923.0DomainPyrin
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957220_536889.6666666666666923.0DomainNACHT
TgeneNLRP3chrX:137939674chr1:247611707ENST00000366496681_93946.6666666666666980.0DomainPyrin
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668220_536946.6666666666666980.0DomainNACHT
TgeneNLRP3chrX:137939674chr1:247611707ENST00000366497791_93946.6666666666666980.0DomainPyrin
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779220_536946.6666666666666980.0DomainNACHT
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391827681_93946.6666666666666980.0DomainPyrin
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768220_536946.6666666666666980.0DomainNACHT
TgeneNLRP3chrX:137939674chr1:247611707ENST000003918289111_931003.66666666666661037.0DomainPyrin
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911220_5361003.66666666666661037.0DomainNACHT
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979226_2331003.66666666666661037.0Nucleotide bindingATP
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957226_233889.6666666666666923.0Nucleotide bindingATP
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668226_233946.6666666666666980.0Nucleotide bindingATP
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779226_233946.6666666666666980.0Nucleotide bindingATP
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768226_233946.6666666666666980.0Nucleotide bindingATP
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911226_2331003.66666666666661037.0Nucleotide bindingATP
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979742_7621003.66666666666661037.0RepeatNote=LRR 1
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979771_7921003.66666666666661037.0RepeatNote=LRR 2
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979799_8191003.66666666666661037.0RepeatNote=LRR 3
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979828_8491003.66666666666661037.0RepeatNote=LRR 4
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979856_8761003.66666666666661037.0RepeatNote=LRR 5
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979885_9061003.66666666666661037.0RepeatNote=LRR 6
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979913_9331003.66666666666661037.0RepeatNote=LRR 7
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979942_9631003.66666666666661037.0RepeatNote=LRR 8
TgeneNLRP3chrX:137939674chr1:247611707ENST0000033611979970_9911003.66666666666661037.0RepeatNote=LRR 9
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957742_762889.6666666666666923.0RepeatNote=LRR 1
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957771_792889.6666666666666923.0RepeatNote=LRR 2
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957799_819889.6666666666666923.0RepeatNote=LRR 3
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957828_849889.6666666666666923.0RepeatNote=LRR 4
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957856_876889.6666666666666923.0RepeatNote=LRR 5
TgeneNLRP3chrX:137939674chr1:247611707ENST0000034806957885_906889.6666666666666923.0RepeatNote=LRR 6
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668742_762946.6666666666666980.0RepeatNote=LRR 1
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668771_792946.6666666666666980.0RepeatNote=LRR 2
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668799_819946.6666666666666980.0RepeatNote=LRR 3
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668828_849946.6666666666666980.0RepeatNote=LRR 4
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668856_876946.6666666666666980.0RepeatNote=LRR 5
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668885_906946.6666666666666980.0RepeatNote=LRR 6
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668913_933946.6666666666666980.0RepeatNote=LRR 7
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649668942_963946.6666666666666980.0RepeatNote=LRR 8
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779742_762946.6666666666666980.0RepeatNote=LRR 1
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779771_792946.6666666666666980.0RepeatNote=LRR 2
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779799_819946.6666666666666980.0RepeatNote=LRR 3
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779828_849946.6666666666666980.0RepeatNote=LRR 4
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779856_876946.6666666666666980.0RepeatNote=LRR 5
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779885_906946.6666666666666980.0RepeatNote=LRR 6
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779913_933946.6666666666666980.0RepeatNote=LRR 7
TgeneNLRP3chrX:137939674chr1:247611707ENST0000036649779942_963946.6666666666666980.0RepeatNote=LRR 8
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768742_762946.6666666666666980.0RepeatNote=LRR 1
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768771_792946.6666666666666980.0RepeatNote=LRR 2
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768799_819946.6666666666666980.0RepeatNote=LRR 3
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768828_849946.6666666666666980.0RepeatNote=LRR 4
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768856_876946.6666666666666980.0RepeatNote=LRR 5
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768885_906946.6666666666666980.0RepeatNote=LRR 6
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768913_933946.6666666666666980.0RepeatNote=LRR 7
TgeneNLRP3chrX:137939674chr1:247611707ENST0000039182768942_963946.6666666666666980.0RepeatNote=LRR 8
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911742_7621003.66666666666661037.0RepeatNote=LRR 1
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911771_7921003.66666666666661037.0RepeatNote=LRR 2
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911799_8191003.66666666666661037.0RepeatNote=LRR 3
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911828_8491003.66666666666661037.0RepeatNote=LRR 4
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911856_8761003.66666666666661037.0RepeatNote=LRR 5
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911885_9061003.66666666666661037.0RepeatNote=LRR 6
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911913_9331003.66666666666661037.0RepeatNote=LRR 7
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911942_9631003.66666666666661037.0RepeatNote=LRR 8
TgeneNLRP3chrX:137939674chr1:247611707ENST00000391828911970_9911003.66666666666661037.0RepeatNote=LRR 9


Top

Fusion Gene Sequence for FGF13-NLRP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000441825_ENST00000391827_TCGA-A2-A04U-01A_FGF13_chrX_137939674_-_NLRP3_chr1_247611707_length(transcript)=268nt_BP=168nt
TTCTGGATGACGCCCCCCCTGGCACACAGGAATACATTATGTTACGACAAGATTCCATCCAATCTGCGGAATTAAAGAAAAAAGAGTCCC
CCTTTCGTGCTAAGTGTCACGAAATCTTCTGCTGCCCGCTGAAGCAAGTACACCACAAAGAGAACACAGAGCCGGAAGGTTGTCTGAAAT

>In-frame_ENST00000441825_ENST00000391827_TCGA-A2-A04U-01A_FGF13_chrX_137939674_-_NLRP3_chr1_247611707_length(amino acids)=69AA_start in transcript=2_stop in transcript=211

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for FGF13-NLRP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for FGF13-NLRP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for FGF13-NLRP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGF13C0027627Neoplasm Metastasis1CTD_human
HgeneFGF13C0030297Pancreatic Neoplasm1CTD_human
HgeneFGF13C0346647Malignant neoplasm of pancreas1CTD_human
TgeneNLRP3C0409818Chronic Infantile Neurological, Cutaneous, and Articular Syndrome11CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneNLRP3C4551895Familial Cold Autoinflammatory Syndrome 111CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNLRP3C0268390Muckle-Wells Syndrome10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneNLRP3C0343068Familial cold urticaria4CTD_human;ORPHANET
TgeneNLRP3C2316212Cryopyrin-Associated Periodic Syndromes3CTD_human
TgeneNLRP3C0021368Inflammation2CTD_human
TgeneNLRP3C4521680DEAFNESS, AUTOSOMAL DOMINANT 34, WITH OR WITHOUT INFLAMMATION2GENOMICS_ENGLAND;UNIPROT
TgeneNLRP3C0001144Acne Vulgaris1CTD_human
TgeneNLRP3C0002792anaphylaxis1CTD_human
TgeneNLRP3C0003949Asbestosis1CTD_human
TgeneNLRP3C0010346Crohn Disease1CTD_human
TgeneNLRP3C0013182Drug Allergy1CTD_human
TgeneNLRP3C0016470Food Allergy1CTD_human
TgeneNLRP3C0026769Multiple Sclerosis1CTD_human
TgeneNLRP3C0085652Pyoderma Gangrenosum1CTD_human
TgeneNLRP3C0156147Crohn's disease of large bowel1CTD_human
TgeneNLRP3C0162836Hidradenitis Suppurativa1CTD_human
TgeneNLRP3C0267380Crohn's disease of the ileum1CTD_human
TgeneNLRP3C0678202Regional enteritis1CTD_human
TgeneNLRP3C0702166Acne1CTD_human
TgeneNLRP3C0751324Multiple Sclerosis, Acute Fulminating1CTD_human
TgeneNLRP3C0949272IIeocolitis1CTD_human
TgeneNLRP3C1835697Keratitis Fugax Hereditaria1UNIPROT
TgeneNLRP3C2930617Pulmonary Fibrosis - from Asbestos Exposure1CTD_human
TgeneNLRP3C3860213Autoinflammatory disorder1GENOMICS_ENGLAND