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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FGFR1-PLAG1 (FusionGDB2 ID:30163)

Fusion Gene Summary for FGFR1-PLAG1

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR1-PLAG1
Fusion gene ID: 30163
HgeneTgene
Gene symbol

FGFR1

PLAG1

Gene ID

2260

5324

Gene namefibroblast growth factor receptor 1PLAG1 zinc finger
SynonymsBFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1PSA|SGPA|ZNF912
Cytomap

8p11.23

8q12.1

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgrzinc finger protein PLAG1COL1A2/PLAG1 fusionHAS2/PLAG1 fusionpleiomorphic adenoma gene 1
Modification date2020032920200329
UniProtAcc

P11362

.
Ensembl transtripts involved in fusion geneENST00000425967, ENST00000397091, 
ENST00000447712, ENST00000341462, 
ENST00000532791, ENST00000397113, 
ENST00000356207, ENST00000335922, 
ENST00000326324, ENST00000397103, 
ENST00000397108, ENST00000496629, 
ENST00000316981, ENST00000423799, 
ENST00000429357, ENST00000519027, 
Fusion gene scores* DoF score17 X 24 X 9=367213 X 16 X 7=1456
# samples 209
** MAII scorelog2(20/3672*10)=-4.19849415363908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/1456*10)=-4.01594154386902
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR1 [Title/Abstract] AND PLAG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFGFR1(38325518)-PLAG1(57080872), # samples:1
FGFR1(38314872)-PLAG1(57092074), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

HgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

HgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

HgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

HgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851

TgenePLAG1

GO:0045944

positive regulation of transcription by RNA polymerase II

10646861


check buttonFusion gene breakpoints across FGFR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PLAG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4mucoepidermoid carcinomaEF525170FGFR1chr8

38325518

PLAG1chr8

57080872

ChiTaRS5.0N/AEF525170FGFR1chr8

38314872

-PLAG1chr8

57092074

-


Top

Fusion Gene ORF analysis for FGFR1-PLAG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000425967ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000425967ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000425967ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000425967ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000397091ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000397091ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000397091ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000397091ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000447712ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000447712ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000447712ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000447712ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000341462ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000341462ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000341462ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000341462ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000532791ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000532791ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000532791ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000532791ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000397113ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000397113ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000397113ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000397113ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000356207ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000356207ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000356207ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000356207ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000335922ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000335922ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000335922ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000335922ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000326324ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000326324ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000326324ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000326324ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000397103ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000397103ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000397103ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000397103ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000397108ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000397108ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000397108ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000397108ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000496629ENST00000316981FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000496629ENST00000423799FGFR1chr8

38325518

PLAG1chr8

57080872

intron-5UTRENST00000496629ENST00000429357FGFR1chr8

38325518

PLAG1chr8

57080872

intron-intronENST00000496629ENST00000519027FGFR1chr8

38325518

PLAG1chr8

57080872

5CDS-5UTRENST00000425967ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000425967ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000425967ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000425967ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000397091ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397091ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397091ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397091ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000447712ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000447712ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000447712ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000447712ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000341462ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000341462ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000341462ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000341462ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000532791ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000532791ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000532791ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000532791ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000397113ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397113ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397113ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397113ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000356207ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000356207ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000356207ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000356207ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5UTR-5UTRENST00000335922ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5UTR-intronENST00000335922ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5UTR-intronENST00000335922ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5UTR-intronENST00000335922ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000326324ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000326324ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000326324ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000326324ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000397103ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397103ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397103ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397103ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000397108ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397108ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397108ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-intronENST00000397108ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
intron-5UTRENST00000496629ENST00000316981FGFR1chr8

38314872

-PLAG1chr8

57092074

-
intron-intronENST00000496629ENST00000423799FGFR1chr8

38314872

-PLAG1chr8

57092074

-
intron-intronENST00000496629ENST00000429357FGFR1chr8

38314872

-PLAG1chr8

57092074

-
intron-intronENST00000496629ENST00000519027FGFR1chr8

38314872

-PLAG1chr8

57092074

-
5CDS-5UTRENST00000425967ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
5CDS-intronENST00000425967ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
5CDS-intronENST00000425967ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
5CDS-intronENST00000425967ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
5UTR-3CDSENST00000397108ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-3CDSENST00000397113ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-3CDSENST00000425967ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-5UTRENST00000326324ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-5UTRENST00000335922ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-5UTRENST00000341462ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-5UTRENST00000356207ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-5UTRENST00000397091ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-5UTRENST00000397108ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
5UTR-5UTRENST00000397108ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-5UTRENST00000397108ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-5UTRENST00000397113ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-5UTRENST00000397113ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-5UTRENST00000425967ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-5UTRENST00000425967ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-5UTRENST00000447712ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-5UTRENST00000532791ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000326324ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000326324ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000326324ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000335922ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000335922ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000335922ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000341462ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000341462ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000341462ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000356207ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000356207ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000356207ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000397091ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000397091ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000397091ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000397108ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
5UTR-intronENST00000397108ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
5UTR-intronENST00000397108ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
5UTR-intronENST00000397108ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-intronENST00000397113ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-intronENST00000425967ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
5UTR-intronENST00000447712ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000447712ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000447712ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000532791ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000532791ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
5UTR-intronENST00000532791ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-3CDSENST00000326324ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-3CDSENST00000335922ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-3CDSENST00000341462ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-3CDSENST00000356207ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-3CDSENST00000397091ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-3CDSENST00000397103ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-3CDSENST00000447712ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-3CDSENST00000496629ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-3CDSENST00000532791ENST00000316981FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000326324ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000326324ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000326324ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000335922ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000335922ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000335922ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000341462ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000341462ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000341462ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000356207ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000356207ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000356207ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000397091ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000397091ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000397091ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000397103ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000397103ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-5UTRENST00000397103ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000397103ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000397108ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-5UTRENST00000397113ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000397113ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-5UTRENST00000425967ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-5UTRENST00000447712ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000447712ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000447712ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000496629ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000496629ENST00000316981FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-5UTRENST00000496629ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000496629ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000532791ENST00000316981FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-5UTRENST00000532791ENST00000423799FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-5UTRENST00000532791ENST00000429357FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000326324ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000326324ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000326324ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000326324ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000326324ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000326324ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000326324ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000326324ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000335922ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000335922ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000335922ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000335922ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000335922ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000335922ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000335922ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000335922ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000341462ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000341462ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000341462ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000341462ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000341462ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000341462ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000341462ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000341462ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000356207ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000356207ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000356207ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000356207ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000356207ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000356207ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000356207ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000356207ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397091ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397091ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000397091ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397091ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000397091ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397091ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000397091ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000397091ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397103ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397103ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000397103ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000397103ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397103ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000397103ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000397103ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397103ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000397103ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000397103ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000397103ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397108ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397108ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000397108ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397108ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000397108ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397108ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000397108ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397113ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397113ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000397113ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000397113ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397113ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000397113ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000397113ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000397113ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000397113ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000397113ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000425967ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000425967ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000425967ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000425967ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000425967ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000425967ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000425967ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000447712ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000447712ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000447712ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000447712ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000447712ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000447712ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000447712ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000447712ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000496629ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000496629ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000496629ENST00000423799FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000496629ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000496629ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000496629ENST00000429357FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000496629ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000496629ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000496629ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000496629ENST00000519027FGFR1chr8

38325498

-PLAG1chr8

57092072

-
intron-intronENST00000496629ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000532791ENST00000316981FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000532791ENST00000423799FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000532791ENST00000423799FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000532791ENST00000429357FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000532791ENST00000429357FGFR1chr8

38434211

-PLAG1chr8

57243425

-
intron-intronENST00000532791ENST00000519027FGFR1chr8

38318613

-PLAG1chr8

57092072

-
intron-intronENST00000532791ENST00000519027FGFR1chr8

38325189

-PLAG1chr8

57080062

-
intron-intronENST00000532791ENST00000519027FGFR1chr8

38434211

-PLAG1chr8

57243425

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FGFR1-PLAG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FGFR1-PLAG1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR1

P11362

.
FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FGFR1-PLAG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FGFR1-PLAG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FGFR1-PLAG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR1P11362DB00039PaliferminAgonistBiotechApproved
HgeneFGFR1P11362DB00039PaliferminAgonistBiotechApproved
HgeneFGFR1P11362DB00039PaliferminAgonistBiotechApproved
HgeneFGFR1P11362DB00039PaliferminAgonistBiotechApproved
HgeneFGFR1P11362DB00039PaliferminAgonistBiotechApproved
HgeneFGFR1P11362DB00039PaliferminAgonistBiotechApproved
HgeneFGFR1P11362DB00039PaliferminAgonistBiotechApproved
HgeneFGFR1P11362DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB08896RegorafenibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB09079NintedanibInhibitorSmall moleculeApproved
HgeneFGFR1P11362DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB00398SorafenibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB01109HeparinSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB08901PonatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB09078LenvatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB12147ErdafitinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15102PemigatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15685SelpercatinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational
HgeneFGFR1P11362DB15822PralsetinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for FGFR1-PLAG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR1C1563720Kallmann Syndrome 2 (disorder)18CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C1845146Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate6GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR1C0011570Mental Depression5PSYGENET
HgeneFGFR1C0011581Depressive disorder5CTD_human;PSYGENET
HgeneFGFR1C0220658Pfeiffer Syndrome5GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C0432283Osteoglophonic dwarfism5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR1C0041696Unipolar Depression4CTD_human;PSYGENET
HgeneFGFR1C0406612Encephalocraniocutaneous lipomatosis4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR1C0005586Bipolar Disorder3PSYGENET
HgeneFGFR1C0795998JACKSON-WEISS SYNDROME3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C1269683Major Depressive Disorder3PSYGENET
HgeneFGFR1C0006142Malignant neoplasm of breast2CGI;CTD_human
HgeneFGFR1C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneFGFR1C0007137Squamous cell carcinoma2CTD_human
HgeneFGFR1C0027022Myeloproliferative disease2CTD_human
HgeneFGFR1C0162809Kallmann Syndrome2CTD_human;ORPHANET
HgeneFGFR1C0432122Interfrontal craniofaciosynostosis2GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C0678222Breast Carcinoma2CGI;CTD_human
HgeneFGFR1C1257931Mammary Neoplasms, Human2CTD_human
HgeneFGFR1C1458155Mammary Neoplasms2CTD_human
HgeneFGFR1C4704874Mammary Carcinoma, Human2CTD_human
HgeneFGFR1C0004114Astrocytoma1CTD_human
HgeneFGFR1C0008924Cleft upper lip1CTD_human
HgeneFGFR1C0008925Cleft Palate1CTD_human
HgeneFGFR1C0010278Craniosynostosis1CTD_human;GENOMICS_ENGLAND
HgeneFGFR1C0011573Endogenous depression1CTD_human
HgeneFGFR1C0017638Glioma1CTD_human
HgeneFGFR1C0018824Heart valve disease1CTD_human
HgeneFGFR1C0024121Lung Neoplasms1CTD_human
HgeneFGFR1C0025193Melancholia1CTD_human
HgeneFGFR1C0036341Schizophrenia1CTD_human
HgeneFGFR1C0085682Hypophosphatemia1GENOMICS_ENGLAND
HgeneFGFR1C0086133Depressive Syndrome1CTD_human
HgeneFGFR1C0149925Small cell carcinoma of lung1CTD_human
HgeneFGFR1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneFGFR1C0206726gliosarcoma1ORPHANET
HgeneFGFR1C0242379Malignant neoplasm of lung1CTD_human
HgeneFGFR1C0259783mixed gliomas1CTD_human
HgeneFGFR1C0265535Trigonocephaly1CTD_human;ORPHANET
HgeneFGFR1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneFGFR1C0280785Diffuse Astrocytoma1CTD_human
HgeneFGFR1C0282126Depression, Neurotic1CTD_human
HgeneFGFR1C0334579Anaplastic astrocytoma1CTD_human
HgeneFGFR1C0334580Protoplasmic astrocytoma1CTD_human
HgeneFGFR1C0334581Gemistocytic astrocytoma1CTD_human
HgeneFGFR1C0334582Fibrillary Astrocytoma1CTD_human
HgeneFGFR1C0334583Pilocytic Astrocytoma1CTD_human
HgeneFGFR1C0334588Giant Cell Glioblastoma1ORPHANET
HgeneFGFR1C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneFGFR1C0338503Septo-Optic Dysplasia1ORPHANET
HgeneFGFR1C0342384Idiopathic hypogonadotropic hypogonadism1GENOMICS_ENGLAND
HgeneFGFR1C0376634Craniofacial Abnormalities1CTD_human
HgeneFGFR1C0431362Lobar Holoprosencephaly1ORPHANET
HgeneFGFR1C0547065Mixed oligoastrocytoma1CTD_human
HgeneFGFR1C0555198Malignant Glioma1CTD_human
HgeneFGFR1C0750935Cerebral Astrocytoma1CTD_human
HgeneFGFR1C0750936Intracranial Astrocytoma1CTD_human
HgeneFGFR1C0751617Semilobar Holoprosencephaly1ORPHANET
HgeneFGFR1C1519086Pilomyxoid astrocytoma1ORPHANET
HgeneFGFR1C1704230Grade I Astrocytoma1CTD_human
HgeneFGFR1C1837218Cleft palate, isolated1CTD_human
HgeneFGFR1C1852406Cutis Gyrata Syndrome of Beare And Stevenson1GENOMICS_ENGLAND
HgeneFGFR1C2931196Craniofacial dysostosis type 11GENOMICS_ENGLAND
HgeneFGFR1C3150773CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME1ORPHANET
TgenePLAG1C1519176Salivary Gland Pleomorphic Adenoma2CTD_human;ORPHANET
TgenePLAG1C0175693Russell-Silver syndrome1GENOMICS_ENGLAND
TgenePLAG1C0334475Lipoblastomatosis1CTD_human
TgenePLAG1C0473935Radiolabeled somatostatin analog study1GENOMICS_ENGLAND
TgenePLAG1C0796160MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE1GENOMICS_ENGLAND
TgenePLAG1C1260965Lipoblastoma1CTD_human