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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:FGFR1-TTLL1 (FusionGDB2 ID:30167) |
Fusion Gene Summary for FGFR1-TTLL1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: FGFR1-TTLL1 | Fusion gene ID: 30167 | Hgene | Tgene | Gene symbol | FGFR1 | TTLL1 | Gene ID | 2260 | 25809 |
Gene name | fibroblast growth factor receptor 1 | tubulin tyrosine ligase like 1 | |
Synonyms | BFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1 | C22orf7|HS323M22B | |
Cytomap | 8p11.23 | 22q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | fibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr | probable tubulin polyglutamylase TTLL1PGs3catalytic subunit of neural tubulin polyglutamylasetubulin polyglutamylase complex subunit 3tubulin tyrosine ligase-like family, member 1tubulin--tyrosine ligase-like protein 1tubulin-tyrosine ligase | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P11362 | . | |
Ensembl transtripts involved in fusion gene | ENST00000425967, ENST00000397091, ENST00000447712, ENST00000341462, ENST00000532791, ENST00000397113, ENST00000356207, ENST00000335922, ENST00000326324, ENST00000397103, ENST00000397108, ENST00000496629, | ENST00000331018, ENST00000266254, ENST00000445824, | |
Fusion gene scores | * DoF score | 17 X 24 X 9=3672 | 7 X 8 X 6=336 |
# samples | 20 | 13 | |
** MAII score | log2(20/3672*10)=-4.19849415363908 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/336*10)=-1.36994960975031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FGFR1 [Title/Abstract] AND TTLL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FGFR1(38314874)-TTLL1(43435911), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | FGFR1-TTLL1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. FGFR1-TTLL1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. FGFR1-TTLL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FGFR1 | GO:0008284 | positive regulation of cell proliferation | 8663044 |
Hgene | FGFR1 | GO:0008543 | fibroblast growth factor receptor signaling pathway | 8663044 |
Hgene | FGFR1 | GO:0010863 | positive regulation of phospholipase C activity | 18480409 |
Hgene | FGFR1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 8622701|18480409 |
Hgene | FGFR1 | GO:0043406 | positive regulation of MAP kinase activity | 8622701|18480409 |
Hgene | FGFR1 | GO:0046777 | protein autophosphorylation | 8622701 |
Hgene | FGFR1 | GO:2000546 | positive regulation of endothelial cell chemotaxis to fibroblast growth factor | 21885851 |
Fusion gene breakpoints across FGFR1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across TTLL1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-25-2401-01A | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
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Fusion Gene ORF analysis for FGFR1-TTLL1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000425967 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000425967 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000425967 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000397091 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000397091 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000397091 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000447712 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000447712 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000447712 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000341462 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000341462 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000341462 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000532791 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000532791 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000532791 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000397113 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000397113 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000397113 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000356207 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000356207 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000356207 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5UTR-3CDS | ENST00000335922 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5UTR-3CDS | ENST00000335922 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5UTR-intron | ENST00000335922 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000326324 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000326324 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000326324 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
In-frame | ENST00000397103 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
In-frame | ENST00000397103 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000397103 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000397108 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
Frame-shift | ENST00000397108 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
5CDS-intron | ENST00000397108 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
intron-3CDS | ENST00000496629 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
intron-3CDS | ENST00000496629 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
intron-intron | ENST00000496629 | ENST00000445824 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000397103 | FGFR1 | chr8 | 38314874 | - | ENST00000331018 | TTLL1 | chr22 | 43435911 | - | 538 | 148 | 230 | 30 | 66 |
ENST00000397103 | FGFR1 | chr8 | 38314874 | - | ENST00000266254 | TTLL1 | chr22 | 43435911 | - | 410 | 148 | 298 | 2 | 99 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000397103 | ENST00000331018 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - | 0.83977836 | 0.16022162 |
ENST00000397103 | ENST00000266254 | FGFR1 | chr8 | 38314874 | - | TTLL1 | chr22 | 43435911 | - | 0.9227553 | 0.07724472 |
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Fusion Genomic Features for FGFR1-TTLL1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FGFR1-TTLL1 |
Go to FGviewer for the breakpoints of chr8:38314874-chr22:43435911 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FGFR1 | . |
FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | TTLL1 | chr8:38314874 | chr22:43435911 | ENST00000445824 | 0 | 4 | 1_367 | 0 | 60.0 | Domain | TTL | |
Tgene | TTLL1 | chr8:38314874 | chr22:43435911 | ENST00000445824 | 0 | 4 | 181_184 | 0 | 60.0 | Nucleotide binding | ATP binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 158_246 | 30.333333333333332 | 732.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 255_357 | 30.333333333333332 | 732.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 25_119 | 30.333333333333332 | 732.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 478_767 | 30.333333333333332 | 732.0 | Domain | Protein kinase |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 158_246 | 0 | 813.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 255_357 | 0 | 813.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 25_119 | 0 | 813.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 478_767 | 0 | 813.0 | Domain | Protein kinase |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 158_246 | 30.333333333333332 | 734.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 255_357 | 30.333333333333332 | 734.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 25_119 | 30.333333333333332 | 734.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 478_767 | 30.333333333333332 | 734.0 | Domain | Protein kinase |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 158_246 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 255_357 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 25_119 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 478_767 | 30.333333333333332 | 821.0 | Domain | Protein kinase |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 158_246 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 255_357 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 25_119 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 478_767 | 30.333333333333332 | 821.0 | Domain | Protein kinase |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 158_246 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 255_357 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 25_119 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 478_767 | 30.333333333333332 | 821.0 | Domain | Protein kinase |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 158_246 | 63.333333333333336 | 854.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 255_357 | 63.333333333333336 | 854.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 25_119 | 63.333333333333336 | 854.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 478_767 | 63.333333333333336 | 854.0 | Domain | Protein kinase |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 158_246 | 30.333333333333332 | 823.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 255_357 | 30.333333333333332 | 823.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 25_119 | 30.333333333333332 | 823.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 478_767 | 30.333333333333332 | 823.0 | Domain | Protein kinase |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 158_246 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 2 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 255_357 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 3 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 25_119 | 30.333333333333332 | 821.0 | Domain | Note=Ig-like C2-type 1 |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 478_767 | 30.333333333333332 | 821.0 | Domain | Protein kinase |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 484_490 | 30.333333333333332 | 732.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 562_564 | 30.333333333333332 | 732.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 484_490 | 0 | 813.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 562_564 | 0 | 813.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 484_490 | 30.333333333333332 | 734.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 562_564 | 30.333333333333332 | 734.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 484_490 | 30.333333333333332 | 821.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 562_564 | 30.333333333333332 | 821.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 484_490 | 30.333333333333332 | 821.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 562_564 | 30.333333333333332 | 821.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 484_490 | 30.333333333333332 | 821.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 562_564 | 30.333333333333332 | 821.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 484_490 | 63.333333333333336 | 854.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 562_564 | 63.333333333333336 | 854.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 484_490 | 30.333333333333332 | 823.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 562_564 | 30.333333333333332 | 823.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 484_490 | 30.333333333333332 | 821.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 562_564 | 30.333333333333332 | 821.0 | Nucleotide binding | Note=ATP |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 160_177 | 30.333333333333332 | 732.0 | Region | Note=Heparin-binding |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 160_177 | 0 | 813.0 | Region | Note=Heparin-binding |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 160_177 | 30.333333333333332 | 734.0 | Region | Note=Heparin-binding |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 160_177 | 30.333333333333332 | 821.0 | Region | Note=Heparin-binding |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 160_177 | 30.333333333333332 | 821.0 | Region | Note=Heparin-binding |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 160_177 | 30.333333333333332 | 821.0 | Region | Note=Heparin-binding |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 160_177 | 63.333333333333336 | 854.0 | Region | Note=Heparin-binding |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 160_177 | 30.333333333333332 | 823.0 | Region | Note=Heparin-binding |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 160_177 | 30.333333333333332 | 821.0 | Region | Note=Heparin-binding |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 22_376 | 30.333333333333332 | 732.0 | Topological domain | Extracellular |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 398_822 | 30.333333333333332 | 732.0 | Topological domain | Cytoplasmic |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 22_376 | 0 | 813.0 | Topological domain | Extracellular |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 398_822 | 0 | 813.0 | Topological domain | Cytoplasmic |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 22_376 | 30.333333333333332 | 734.0 | Topological domain | Extracellular |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 398_822 | 30.333333333333332 | 734.0 | Topological domain | Cytoplasmic |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 22_376 | 30.333333333333332 | 821.0 | Topological domain | Extracellular |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 398_822 | 30.333333333333332 | 821.0 | Topological domain | Cytoplasmic |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 22_376 | 30.333333333333332 | 821.0 | Topological domain | Extracellular |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 398_822 | 30.333333333333332 | 821.0 | Topological domain | Cytoplasmic |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 22_376 | 30.333333333333332 | 821.0 | Topological domain | Extracellular |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 398_822 | 30.333333333333332 | 821.0 | Topological domain | Cytoplasmic |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 22_376 | 63.333333333333336 | 854.0 | Topological domain | Extracellular |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 398_822 | 63.333333333333336 | 854.0 | Topological domain | Cytoplasmic |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 22_376 | 30.333333333333332 | 823.0 | Topological domain | Extracellular |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 398_822 | 30.333333333333332 | 823.0 | Topological domain | Cytoplasmic |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 22_376 | 30.333333333333332 | 821.0 | Topological domain | Extracellular |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 398_822 | 30.333333333333332 | 821.0 | Topological domain | Cytoplasmic |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000326324 | - | 2 | 17 | 377_397 | 30.333333333333332 | 732.0 | Transmembrane | Helical |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000335922 | - | 2 | 19 | 377_397 | 0 | 813.0 | Transmembrane | Helical |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000356207 | - | 2 | 17 | 377_397 | 30.333333333333332 | 734.0 | Transmembrane | Helical |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397091 | - | 2 | 18 | 377_397 | 30.333333333333332 | 821.0 | Transmembrane | Helical |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397108 | - | 3 | 19 | 377_397 | 30.333333333333332 | 821.0 | Transmembrane | Helical |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000397113 | - | 2 | 18 | 377_397 | 30.333333333333332 | 821.0 | Transmembrane | Helical |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000425967 | - | 3 | 19 | 377_397 | 63.333333333333336 | 854.0 | Transmembrane | Helical |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000447712 | - | 2 | 18 | 377_397 | 30.333333333333332 | 823.0 | Transmembrane | Helical |
Hgene | FGFR1 | chr8:38314874 | chr22:43435911 | ENST00000532791 | - | 2 | 18 | 377_397 | 30.333333333333332 | 821.0 | Transmembrane | Helical |
Tgene | TTLL1 | chr8:38314874 | chr22:43435911 | ENST00000266254 | 9 | 11 | 1_367 | 380.6666666666667 | 424.0 | Domain | TTL | |
Tgene | TTLL1 | chr8:38314874 | chr22:43435911 | ENST00000331018 | 8 | 10 | 1_367 | 351.6666666666667 | 395.0 | Domain | TTL | |
Tgene | TTLL1 | chr8:38314874 | chr22:43435911 | ENST00000266254 | 9 | 11 | 181_184 | 380.6666666666667 | 424.0 | Nucleotide binding | ATP binding | |
Tgene | TTLL1 | chr8:38314874 | chr22:43435911 | ENST00000331018 | 8 | 10 | 181_184 | 351.6666666666667 | 395.0 | Nucleotide binding | ATP binding |
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Fusion Gene Sequence for FGFR1-TTLL1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000397103_ENST00000331018_TCGA-25-2401-01A_FGFR1_chr8_38314874_-_TTLL1_chr22_43435911_length(transcript)=538nt_BP=148nt GTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCT GTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGGTATGATGAAGAATTGGCCCAGGGTGACGGGG CTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCT GGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTGGGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAG CTTTTTTCCTTTCCTAAGCCCTGTAAATAAACGAAGGCACTTCTTTGGAAGGTTATGGAGTCTGTTTGACTAGTGCTAAAGGAAACAATT >In-frame_ENST00000397103_ENST00000331018_TCGA-25-2401-01A_FGFR1_chr8_38314874_-_TTLL1_chr22_43435911_length(amino acids)=66AA_start in transcript=230_stop in transcript=30 -------------------------------------------------------------- >In-frame_ENST00000397103_ENST00000266254_TCGA-25-2401-01A_FGFR1_chr8_38314874_-_TTLL1_chr22_43435911_length(transcript)=410nt_BP=148nt GTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCT GTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGGTATGATGAAGAATTGGCCCAGGGTGACGGGG CTGACCGGGAGCTGAGAAGCCGTCAGGGTCAGTCTCTGGGGCCCAGAGCAGGCCGATCGAGAGACTCGGGGAGAGCGGTCCTCACCACCT GGAAGTGAGTCCCACCTGGACCTTATCAAAACTACTCACTCCACCTGGGCCCCTGCTGAAGCCCTATTTTGAAATTTCCCTTTTGTAGAG >In-frame_ENST00000397103_ENST00000266254_TCGA-25-2401-01A_FGFR1_chr8_38314874_-_TTLL1_chr22_43435911_length(amino acids)=99AA_start in transcript=298_stop in transcript=2 MIRSRWDSLPGGEDRSPRVSRSACSGPQRLTLTASQLPVSPVTLGQFFIIPCSGKVGDGLAVQSVAVTSTAQKRRHFQLHIPVLQLEVGD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FGFR1-TTLL1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FGFR1-TTLL1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | FGFR1 | P11362 | DB00039 | Palifermin | Agonist | Biotech | Approved |
Hgene | FGFR1 | P11362 | DB00039 | Palifermin | Agonist | Biotech | Approved |
Hgene | FGFR1 | P11362 | DB00039 | Palifermin | Agonist | Biotech | Approved |
Hgene | FGFR1 | P11362 | DB00039 | Palifermin | Agonist | Biotech | Approved |
Hgene | FGFR1 | P11362 | DB00039 | Palifermin | Agonist | Biotech | Approved |
Hgene | FGFR1 | P11362 | DB00039 | Palifermin | Agonist | Biotech | Approved |
Hgene | FGFR1 | P11362 | DB00039 | Palifermin | Agonist | Biotech | Approved |
Hgene | FGFR1 | P11362 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB08896 | Regorafenib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB09079 | Nintedanib | Inhibitor | Small molecule | Approved |
Hgene | FGFR1 | P11362 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB00398 | Sorafenib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Hgene | FGFR1 | P11362 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Hgene | FGFR1 | P11362 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Hgene | FGFR1 | P11362 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Hgene | FGFR1 | P11362 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Hgene | FGFR1 | P11362 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Hgene | FGFR1 | P11362 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
Hgene | FGFR1 | P11362 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15685 | Selpercatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | FGFR1 | P11362 | DB15822 | Pralsetinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for FGFR1-TTLL1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FGFR1 | C1563720 | Kallmann Syndrome 2 (disorder) | 18 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | FGFR1 | C1845146 | Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate | 6 | GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | FGFR1 | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | FGFR1 | C0011581 | Depressive disorder | 5 | CTD_human;PSYGENET |
Hgene | FGFR1 | C0220658 | Pfeiffer Syndrome | 5 | GENOMICS_ENGLAND;UNIPROT |
Hgene | FGFR1 | C0432283 | Osteoglophonic dwarfism | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | FGFR1 | C0041696 | Unipolar Depression | 4 | CTD_human;PSYGENET |
Hgene | FGFR1 | C0406612 | Encephalocraniocutaneous lipomatosis | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | FGFR1 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
Hgene | FGFR1 | C0795998 | JACKSON-WEISS SYNDROME | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | FGFR1 | C1269683 | Major Depressive Disorder | 3 | PSYGENET |
Hgene | FGFR1 | C0006142 | Malignant neoplasm of breast | 2 | CGI;CTD_human |
Hgene | FGFR1 | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
Hgene | FGFR1 | C0007137 | Squamous cell carcinoma | 2 | CTD_human |
Hgene | FGFR1 | C0027022 | Myeloproliferative disease | 2 | CTD_human |
Hgene | FGFR1 | C0162809 | Kallmann Syndrome | 2 | CTD_human;ORPHANET |
Hgene | FGFR1 | C0432122 | Interfrontal craniofaciosynostosis | 2 | GENOMICS_ENGLAND;UNIPROT |
Hgene | FGFR1 | C0678222 | Breast Carcinoma | 2 | CGI;CTD_human |
Hgene | FGFR1 | C1257931 | Mammary Neoplasms, Human | 2 | CTD_human |
Hgene | FGFR1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | FGFR1 | C4704874 | Mammary Carcinoma, Human | 2 | CTD_human |
Hgene | FGFR1 | C0004114 | Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0008924 | Cleft upper lip | 1 | CTD_human |
Hgene | FGFR1 | C0008925 | Cleft Palate | 1 | CTD_human |
Hgene | FGFR1 | C0010278 | Craniosynostosis | 1 | CTD_human;GENOMICS_ENGLAND |
Hgene | FGFR1 | C0011573 | Endogenous depression | 1 | CTD_human |
Hgene | FGFR1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | FGFR1 | C0018824 | Heart valve disease | 1 | CTD_human |
Hgene | FGFR1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | FGFR1 | C0025193 | Melancholia | 1 | CTD_human |
Hgene | FGFR1 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | FGFR1 | C0085682 | Hypophosphatemia | 1 | GENOMICS_ENGLAND |
Hgene | FGFR1 | C0086133 | Depressive Syndrome | 1 | CTD_human |
Hgene | FGFR1 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Hgene | FGFR1 | C0205768 | Subependymal Giant Cell Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0206726 | gliosarcoma | 1 | ORPHANET |
Hgene | FGFR1 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Hgene | FGFR1 | C0259783 | mixed gliomas | 1 | CTD_human |
Hgene | FGFR1 | C0265535 | Trigonocephaly | 1 | CTD_human;ORPHANET |
Hgene | FGFR1 | C0280783 | Juvenile Pilocytic Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0280785 | Diffuse Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0282126 | Depression, Neurotic | 1 | CTD_human |
Hgene | FGFR1 | C0334579 | Anaplastic astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0334580 | Protoplasmic astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0334581 | Gemistocytic astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0334582 | Fibrillary Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0334583 | Pilocytic Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0334588 | Giant Cell Glioblastoma | 1 | ORPHANET |
Hgene | FGFR1 | C0338070 | Childhood Cerebral Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0338503 | Septo-Optic Dysplasia | 1 | ORPHANET |
Hgene | FGFR1 | C0342384 | Idiopathic hypogonadotropic hypogonadism | 1 | GENOMICS_ENGLAND |
Hgene | FGFR1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | FGFR1 | C0431362 | Lobar Holoprosencephaly | 1 | ORPHANET |
Hgene | FGFR1 | C0547065 | Mixed oligoastrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0555198 | Malignant Glioma | 1 | CTD_human |
Hgene | FGFR1 | C0750935 | Cerebral Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0750936 | Intracranial Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C0751617 | Semilobar Holoprosencephaly | 1 | ORPHANET |
Hgene | FGFR1 | C1519086 | Pilomyxoid astrocytoma | 1 | ORPHANET |
Hgene | FGFR1 | C1704230 | Grade I Astrocytoma | 1 | CTD_human |
Hgene | FGFR1 | C1837218 | Cleft palate, isolated | 1 | CTD_human |
Hgene | FGFR1 | C1852406 | Cutis Gyrata Syndrome of Beare And Stevenson | 1 | GENOMICS_ENGLAND |
Hgene | FGFR1 | C2931196 | Craniofacial dysostosis type 1 | 1 | GENOMICS_ENGLAND |
Hgene | FGFR1 | C3150773 | CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME | 1 | ORPHANET |