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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FGFR4-CCDC137 (FusionGDB2 ID:30219) |
Fusion Gene Summary for FGFR4-CCDC137 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FGFR4-CCDC137 | Fusion gene ID: 30219 | Hgene | Tgene | Gene symbol | FGFR4 | CCDC137 | Gene ID | 2264 | 339230 |
| Gene name | fibroblast growth factor receptor 4 | coiled-coil domain containing 137 | |
| Synonyms | CD334|JTK2|TKF | RaRF | |
| Cytomap | 5q35.2 | 17q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fibroblast growth factor receptor 4hydroxyaryl-protein kinaseprotein-tyrosine kinasetyrosine kinase related to fibroblast growth factor receptortyrosylprotein kinase | coiled-coil domain-containing protein 137hepatocellular carcinoma related protein 2retinoic acid resistance factor | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P22455 | Q6PK04 | |
| Ensembl transtripts involved in fusion gene | ENST00000292408, ENST00000393648, ENST00000502906, ENST00000292410, ENST00000507708, ENST00000393637, | ENST00000329214, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 3=48 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FGFR4 [Title/Abstract] AND CCDC137 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FGFR4(176519512)-CCDC137(79634758), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | FGFR4-CCDC137 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. FGFR4-CCDC137 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. FGFR4-CCDC137 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FGFR4-CCDC137 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FGFR4 | GO:0008284 | positive regulation of cell proliferation | 8663044 |
| Hgene | FGFR4 | GO:0008543 | fibroblast growth factor receptor signaling pathway | 21653700 |
| Hgene | FGFR4 | GO:0018108 | peptidyl-tyrosine phosphorylation | 18480409|20683963 |
| Hgene | FGFR4 | GO:0046777 | protein autophosphorylation | 20798051 |
| Fusion gene breakpoints across FGFR4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CCDC137 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8289 | FGFR4 | chr5 | 176519512 | + | CCDC137 | chr17 | 79634758 | + |
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Fusion Gene ORF analysis for FGFR4-CCDC137 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000292408 | ENST00000329214 | FGFR4 | chr5 | 176519512 | + | CCDC137 | chr17 | 79634758 | + |
| Frame-shift | ENST00000393648 | ENST00000329214 | FGFR4 | chr5 | 176519512 | + | CCDC137 | chr17 | 79634758 | + |
| Frame-shift | ENST00000502906 | ENST00000329214 | FGFR4 | chr5 | 176519512 | + | CCDC137 | chr17 | 79634758 | + |
| Frame-shift | ENST00000292410 | ENST00000329214 | FGFR4 | chr5 | 176519512 | + | CCDC137 | chr17 | 79634758 | + |
| intron-3CDS | ENST00000507708 | ENST00000329214 | FGFR4 | chr5 | 176519512 | + | CCDC137 | chr17 | 79634758 | + |
| Frame-shift | ENST00000393637 | ENST00000329214 | FGFR4 | chr5 | 176519512 | + | CCDC137 | chr17 | 79634758 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FGFR4-CCDC137 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FGFR4 | chr5 | 176519512 | + | CCDC137 | chr17 | 79634758 | + | 0.003740415 | 0.99625957 |
| FGFR4 | chr5 | 176519512 | + | CCDC137 | chr17 | 79634758 | + | 0.003740415 | 0.99625957 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FGFR4-CCDC137 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FGFR4 | CCDC137 |
| FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. {ECO:0000269|PubMed:11433297, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:18670643, ECO:0000269|PubMed:20018895, ECO:0000269|PubMed:20683963, ECO:0000269|PubMed:20798051, ECO:0000269|PubMed:20876804, ECO:0000269|PubMed:21653700, ECO:0000269|PubMed:7518429, ECO:0000269|PubMed:7680645, ECO:0000269|PubMed:8663044}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FGFR4-CCDC137 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for FGFR4-CCDC137 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FGFR4-CCDC137 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | FGFR4 | P22455 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
| Hgene | FGFR4 | P22455 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
| Hgene | FGFR4 | P22455 | DB01109 | Heparin | Small molecule | Approved|Investigational | |
| Hgene | FGFR4 | P22455 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB08901 | Ponatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB09078 | Lenvatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB12147 | Erdafitinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
| Hgene | FGFR4 | P22455 | DB15102 | Pemigatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for FGFR4-CCDC137 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FGFR4 | C0376358 | Malignant neoplasm of prostate | 5 | CTD_human;UNIPROT |
| Hgene | FGFR4 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | FGFR4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | FGFR4 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
| Tgene | CCDC137 | C0036341 | Schizophrenia | 1 | CTD_human |
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