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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FIP1L1-FIP1L1 (FusionGDB2 ID:30329)

Fusion Gene Summary for FIP1L1-FIP1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: FIP1L1-FIP1L1
Fusion gene ID: 30329
HgeneTgene
Gene symbol

FIP1L1

FIP1L1

Gene ID

81608

81608

Gene namefactor interacting with PAPOLA and CPSF1factor interacting with PAPOLA and CPSF1
SynonymsFIP1|Rhe|hFip1FIP1|Rhe|hFip1
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionpre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophiliapre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia
Modification date2020031320200313
UniProtAcc

Q6UN15

Q6UN15

Ensembl transtripts involved in fusion geneENST00000507166, ENST00000358575, 
ENST00000337488, ENST00000507922, 
ENST00000306932, ENST00000510668, 
ENST00000507166, ENST00000358575, 
ENST00000337488, ENST00000507922, 
ENST00000306932, ENST00000510668, 
Fusion gene scores* DoF score9 X 10 X 8=72017 X 15 X 11=2805
# samples 1323
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2805*10)=-3.60829500455178
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FIP1L1 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFIP1L1(54282390)-FIP1L1(54262298), # samples:1
FIP1L1(54310271)-FIP1L1(54292038), # samples:1
FIP1L1(54319300)-FIP1L1(54280779), # samples:1
Anticipated loss of major functional domain due to fusion event.FIP1L1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FIP1L1-FIP1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FIP1L1-FIP1L1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FIP1L1-FIP1L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FIP1L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FIP1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAJ708056FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
ChiTaRS5.0N/ABF763372FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
ChiTaRS5.0N/ABF801893FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+


Top

Fusion Gene ORF analysis for FIP1L1-FIP1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000507166ENST00000507166FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000358575FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000337488FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000507922FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000306932FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000510668FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000507166FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000358575FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000337488FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000507922FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000306932FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000510668FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000507166FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000358575FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000337488FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000507922FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000306932FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000510668FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000507166FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000358575FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000337488FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000507922FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000306932FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000510668FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000507166FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000358575FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000337488FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000507922FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000306932FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000510668FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000507166FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000358575FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000337488FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000507922FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000306932FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000510668FIP1L1chr4

54282390

+FIP1L1chr4

54262298

+
intron-3CDSENST00000507166ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507166ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507166ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507166ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507166ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-intronENST00000507166ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
5CDS-intronENST00000358575ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
5CDS-intronENST00000337488ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-intronENST00000507922ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
5CDS-intronENST00000306932ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-intronENST00000510668ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507166ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507166ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507166ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507166ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000507166ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000507166ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000358575ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000358575ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000358575ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000358575ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000358575ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000358575ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000337488ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000337488ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000337488ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000337488ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000337488ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000337488ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507922ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507922ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507922ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507922ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000507922ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000507922ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000306932ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000306932ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000306932ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000306932ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000306932ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000306932ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000510668ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000510668ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000510668ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000510668ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000510668ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000510668ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FIP1L1-FIP1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FIP1L1chr454319300+FIP1L1chr454280781+2.26E-060.99999774
FIP1L1chr454310270+FIP1L1chr454292038+3.67E-070.99999964
FIP1L1chr454319300+FIP1L1chr454280781+2.26E-060.99999774
FIP1L1chr454310270+FIP1L1chr454292038+3.67E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for FIP1L1-FIP1L1


check button Go to

FGviewer for the breakpoints of chr4:54319300-chr4:54280779

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FIP1L1

Q6UN15

FIP1L1

Q6UN15

FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000306932+1315356_406425.6666666666667521.0Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000337488+1618356_406499.6666666666667595.0Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000358575+1618356_406493.6666666666667589.0Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000306932+13151_356425.6666666666667521.0RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000337488+16181_356499.6666666666667595.0RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000337488+1618457_490499.6666666666667595.0RegionArg/Asp/Glu-rich domain
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000358575+16181_356493.6666666666667589.0RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000358575+1618457_490493.6666666666667589.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000306932015356_4060521.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000306932015456_5620521.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000306932015478_5940521.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000337488918356_406271.6666666666667595.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000337488918456_562271.6666666666667595.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000337488918478_594271.6666666666667595.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000358575818356_406256.6666666666667589.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000358575818456_562256.6666666666667589.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000358575818478_594256.6666666666667589.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000507166924356_406271.6666666666667850.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000507166924456_562271.6666666666667850.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000507166924478_594271.6666666666667850.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000507922812356_406256.6666666666667379.0Compositional biasNote=Pro-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000507922812456_562256.6666666666667379.0Compositional biasNote=Arg-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000507922812478_594256.6666666666667379.0Compositional biasNote=Glu-rich
TgeneFIP1L1chr4:54319300chr4:54280779ENST000003069320151_3560521.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000306932015457_4900521.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000337488918457_490271.6666666666667595.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000358575818457_490256.6666666666667589.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000507166924457_490271.6666666666667850.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:54319300chr4:54280779ENST00000507922812457_490256.6666666666667379.0RegionArg/Asp/Glu-rich domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000306932+1315456_562425.6666666666667521.0Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000306932+1315478_594425.6666666666667521.0Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000337488+1618456_562499.6666666666667595.0Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000337488+1618478_594499.6666666666667595.0Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000358575+1618456_562493.6666666666667589.0Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000358575+1618478_594493.6666666666667589.0Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507166+124356_4060.0850.0Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507166+124456_5620.0850.0Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507166+124478_5940.0850.0Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507922+112356_4060379.0Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507922+112456_5620379.0Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507922+112478_5940379.0Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000306932+1315457_490425.6666666666667521.0RegionArg/Asp/Glu-rich domain
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507166+1241_3560.0850.0RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507166+124457_4900.0850.0RegionArg/Asp/Glu-rich domain
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507922+1121_3560379.0RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54319300chr4:54280779ENST00000507922+112457_4900379.0RegionArg/Asp/Glu-rich domain
TgeneFIP1L1chr4:54319300chr4:54280779ENST000003374889181_356271.6666666666667595.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chr4:54319300chr4:54280779ENST000003585758181_356256.6666666666667589.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chr4:54319300chr4:54280779ENST000005071669241_356271.6666666666667850.0RegionNote=Necessary for stimulating PAPOLA activity
TgeneFIP1L1chr4:54319300chr4:54280779ENST000005079228121_356256.6666666666667379.0RegionNote=Necessary for stimulating PAPOLA activity


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Fusion Gene Sequence for FIP1L1-FIP1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FIP1L1-FIP1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FIP1L1-FIP1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FIP1L1-FIP1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFIP1L1C0346421Chronic eosinophilic leukemia4ORPHANET
HgeneFIP1L1C0206141Idiopathic Hypereosinophilic Syndrome2CTD_human
HgeneFIP1L1C0206142Eosinophilic leukemia2CTD_human
HgeneFIP1L1C0206143Loeffler's Endocarditis2CTD_human
HgeneFIP1L1C1540912Hypereosinophilic syndrome2CTD_human
HgeneFIP1L1C0018801Heart failure1CTD_human
HgeneFIP1L1C0018802Congestive heart failure1CTD_human
HgeneFIP1L1C0023212Left-Sided Heart Failure1CTD_human
HgeneFIP1L1C0023487Acute Promyelocytic Leukemia1ORPHANET
HgeneFIP1L1C0235527Heart Failure, Right-Sided1CTD_human
HgeneFIP1L1C1959583Myocardial Failure1CTD_human
HgeneFIP1L1C1961112Heart Decompensation1CTD_human
TgeneFIP1L1C0346421Chronic eosinophilic leukemia4ORPHANET
TgeneFIP1L1C0206141Idiopathic Hypereosinophilic Syndrome2CTD_human
TgeneFIP1L1C0206142Eosinophilic leukemia2CTD_human
TgeneFIP1L1C0206143Loeffler's Endocarditis2CTD_human
TgeneFIP1L1C1540912Hypereosinophilic syndrome2CTD_human
TgeneFIP1L1C0018801Heart failure1CTD_human
TgeneFIP1L1C0018802Congestive heart failure1CTD_human
TgeneFIP1L1C0023212Left-Sided Heart Failure1CTD_human
TgeneFIP1L1C0023487Acute Promyelocytic Leukemia1ORPHANET
TgeneFIP1L1C0235527Heart Failure, Right-Sided1CTD_human
TgeneFIP1L1C1959583Myocardial Failure1CTD_human
TgeneFIP1L1C1961112Heart Decompensation1CTD_human