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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:FKBP10-FAM134C (FusionGDB2 ID:30349) |
Fusion Gene Summary for FKBP10-FAM134C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FKBP10-FAM134C | Fusion gene ID: 30349 | Hgene | Tgene | Gene symbol | FKBP10 | FAM134C | Gene ID | 60681 | 162427 |
| Gene name | FKBP prolyl isomerase 10 | reticulophagy regulator family member 3 | |
| Synonyms | BRKS1|FKBP65|OI11|OI6|PPIASE|hFKBP65 | FAM134C | |
| Cytomap | 17q21.2 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peptidyl-prolyl cis-trans isomerase FKBP1065 kDa FK506-binding protein65 kDa FKBPFK506 binding protein 10, 65 kDaFK506-binding protein 10FKBP-10FKBP-65PPIase FKBP10immunophilin FKBP65rotamase | reticulophagy regulator 3family with sequence similarity 134 member Cprotein FAM134C | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q96AY3 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000321562, ENST00000544340, | ENST00000309428, ENST00000585894, ENST00000543197, | |
| Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 13 X 10 X 6=780 |
| # samples | 8 | 16 | |
| ** MAII score | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/780*10)=-2.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FKBP10 [Title/Abstract] AND FAM134C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | FKBP10(39973455)-FAM134C(40739882), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across FKBP10 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across FAM134C (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-L5-A4OW | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - |
| ChimerDB4 | ESCA | TCGA-L5-A4OW | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - |
| ChimerDB4 | ESCA | TCGA-L5-A4OW | FKBP10 | chr17 | 39969531 | + | FAM134C | chr17 | 40738909 | - |
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Fusion Gene ORF analysis for FKBP10-FAM134C |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000321562 | ENST00000309428 | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - |
| In-frame | ENST00000321562 | ENST00000585894 | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - |
| 5CDS-intron | ENST00000321562 | ENST00000543197 | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - |
| intron-3CDS | ENST00000544340 | ENST00000309428 | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - |
| intron-3CDS | ENST00000544340 | ENST00000585894 | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - |
| intron-intron | ENST00000544340 | ENST00000543197 | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - |
| In-frame | ENST00000321562 | ENST00000309428 | FKBP10 | chr17 | 39969531 | + | FAM134C | chr17 | 40738909 | - |
| In-frame | ENST00000321562 | ENST00000585894 | FKBP10 | chr17 | 39969531 | + | FAM134C | chr17 | 40738909 | - |
| 5CDS-5UTR | ENST00000321562 | ENST00000543197 | FKBP10 | chr17 | 39969531 | + | FAM134C | chr17 | 40738909 | - |
| intron-3CDS | ENST00000544340 | ENST00000309428 | FKBP10 | chr17 | 39969531 | + | FAM134C | chr17 | 40738909 | - |
| intron-3CDS | ENST00000544340 | ENST00000585894 | FKBP10 | chr17 | 39969531 | + | FAM134C | chr17 | 40738909 | - |
| intron-5UTR | ENST00000544340 | ENST00000543197 | FKBP10 | chr17 | 39969531 | + | FAM134C | chr17 | 40738909 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000321562 | FKBP10 | chr17 | 39973455 | + | ENST00000309428 | FAM134C | chr17 | 40739882 | - | 3848 | 495 | 77 | 1549 | 490 |
| ENST00000321562 | FKBP10 | chr17 | 39973455 | + | ENST00000585894 | FAM134C | chr17 | 40739882 | - | 2034 | 495 | 77 | 1549 | 490 |
| ENST00000321562 | FKBP10 | chr17 | 39969531 | + | ENST00000309428 | FAM134C | chr17 | 40738909 | - | 3671 | 349 | 77 | 1372 | 431 |
| ENST00000321562 | FKBP10 | chr17 | 39969531 | + | ENST00000585894 | FAM134C | chr17 | 40738909 | - | 1857 | 349 | 77 | 1372 | 431 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000321562 | ENST00000309428 | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - | 0.005379246 | 0.9946208 |
| ENST00000321562 | ENST00000585894 | FKBP10 | chr17 | 39973455 | + | FAM134C | chr17 | 40739882 | - | 0.016095934 | 0.9839041 |
| ENST00000321562 | ENST00000309428 | FKBP10 | chr17 | 39969531 | + | FAM134C | chr17 | 40738909 | - | 0.004133021 | 0.995867 |
| ENST00000321562 | ENST00000585894 | FKBP10 | chr17 | 39969531 | + | FAM134C | chr17 | 40738909 | - | 0.013696388 | 0.9863036 |
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Fusion Genomic Features for FKBP10-FAM134C |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FKBP10-FAM134C |
| Go to FGviewer for the breakpoints of chr17:39973455-chr17:40739882 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FKBP10 | . |
| FUNCTION: PPIases accelerate the folding of proteins during protein synthesis. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FAM134C | chr17:39969531 | chr17:40738909 | ENST00000309428 | 2 | 9 | 445_450 | 125.66666666666667 | 467.0 | Motif | LIR motif | |
| Tgene | FAM134C | chr17:39973455 | chr17:40739882 | ENST00000309428 | 1 | 9 | 445_450 | 115.33333333333333 | 467.0 | Motif | LIR motif | |
| Tgene | FAM134C | chr17:39969531 | chr17:40738909 | ENST00000309428 | 2 | 9 | 164_184 | 125.66666666666667 | 467.0 | Transmembrane | Helical | |
| Tgene | FAM134C | chr17:39969531 | chr17:40738909 | ENST00000309428 | 2 | 9 | 187_207 | 125.66666666666667 | 467.0 | Transmembrane | Helical | |
| Tgene | FAM134C | chr17:39973455 | chr17:40739882 | ENST00000309428 | 1 | 9 | 164_184 | 115.33333333333333 | 467.0 | Transmembrane | Helical | |
| Tgene | FAM134C | chr17:39973455 | chr17:40739882 | ENST00000309428 | 1 | 9 | 187_207 | 115.33333333333333 | 467.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FKBP10 | chr17:39969531 | chr17:40738909 | ENST00000321562 | + | 1 | 10 | 510_521 | 81.66666666666667 | 583.0 | Calcium binding | 1 |
| Hgene | FKBP10 | chr17:39969531 | chr17:40738909 | ENST00000321562 | + | 1 | 10 | 555_566 | 81.66666666666667 | 583.0 | Calcium binding | 2 |
| Hgene | FKBP10 | chr17:39973455 | chr17:40739882 | ENST00000321562 | + | 2 | 10 | 510_521 | 130.33333333333334 | 583.0 | Calcium binding | 1 |
| Hgene | FKBP10 | chr17:39973455 | chr17:40739882 | ENST00000321562 | + | 2 | 10 | 555_566 | 130.33333333333334 | 583.0 | Calcium binding | 2 |
| Hgene | FKBP10 | chr17:39969531 | chr17:40738909 | ENST00000321562 | + | 1 | 10 | 174_262 | 81.66666666666667 | 583.0 | Domain | PPIase FKBP-type 2 |
| Hgene | FKBP10 | chr17:39969531 | chr17:40738909 | ENST00000321562 | + | 1 | 10 | 286_374 | 81.66666666666667 | 583.0 | Domain | PPIase FKBP-type 3 |
| Hgene | FKBP10 | chr17:39969531 | chr17:40738909 | ENST00000321562 | + | 1 | 10 | 399_486 | 81.66666666666667 | 583.0 | Domain | PPIase FKBP-type 4 |
| Hgene | FKBP10 | chr17:39969531 | chr17:40738909 | ENST00000321562 | + | 1 | 10 | 497_532 | 81.66666666666667 | 583.0 | Domain | EF-hand 1 |
| Hgene | FKBP10 | chr17:39969531 | chr17:40738909 | ENST00000321562 | + | 1 | 10 | 542_577 | 81.66666666666667 | 583.0 | Domain | EF-hand 2 |
| Hgene | FKBP10 | chr17:39969531 | chr17:40738909 | ENST00000321562 | + | 1 | 10 | 62_150 | 81.66666666666667 | 583.0 | Domain | PPIase FKBP-type 1 |
| Hgene | FKBP10 | chr17:39973455 | chr17:40739882 | ENST00000321562 | + | 2 | 10 | 174_262 | 130.33333333333334 | 583.0 | Domain | PPIase FKBP-type 2 |
| Hgene | FKBP10 | chr17:39973455 | chr17:40739882 | ENST00000321562 | + | 2 | 10 | 286_374 | 130.33333333333334 | 583.0 | Domain | PPIase FKBP-type 3 |
| Hgene | FKBP10 | chr17:39973455 | chr17:40739882 | ENST00000321562 | + | 2 | 10 | 399_486 | 130.33333333333334 | 583.0 | Domain | PPIase FKBP-type 4 |
| Hgene | FKBP10 | chr17:39973455 | chr17:40739882 | ENST00000321562 | + | 2 | 10 | 497_532 | 130.33333333333334 | 583.0 | Domain | EF-hand 1 |
| Hgene | FKBP10 | chr17:39973455 | chr17:40739882 | ENST00000321562 | + | 2 | 10 | 542_577 | 130.33333333333334 | 583.0 | Domain | EF-hand 2 |
| Hgene | FKBP10 | chr17:39973455 | chr17:40739882 | ENST00000321562 | + | 2 | 10 | 62_150 | 130.33333333333334 | 583.0 | Domain | PPIase FKBP-type 1 |
| Hgene | FKBP10 | chr17:39969531 | chr17:40738909 | ENST00000321562 | + | 1 | 10 | 579_582 | 81.66666666666667 | 583.0 | Motif | Prevents secretion from ER |
| Hgene | FKBP10 | chr17:39973455 | chr17:40739882 | ENST00000321562 | + | 2 | 10 | 579_582 | 130.33333333333334 | 583.0 | Motif | Prevents secretion from ER |
| Tgene | FAM134C | chr17:39969531 | chr17:40738909 | ENST00000309428 | 2 | 9 | 81_101 | 125.66666666666667 | 467.0 | Transmembrane | Helical | |
| Tgene | FAM134C | chr17:39973455 | chr17:40739882 | ENST00000309428 | 1 | 9 | 81_101 | 115.33333333333333 | 467.0 | Transmembrane | Helical |
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Fusion Gene Sequence for FKBP10-FAM134C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000321562_ENST00000309428_TCGA-L5-A4OW_FKBP10_chr17_39973455_+_FAM134C_chr17_40739882_length(transcript)=3848nt_BP=495nt AGAGGACAGGAAGAGGGGGAGCCAGTTCTGGGAGGCGGGGGGAAGGAGGTTGGTGGCGACTCCCTCGCTCGCCCTCACTGCCGGCGGTCC CAACTCCAGGCACCATGTTCCCCGCGGGCCCCCCCAGCCACAGCCTCCTCCGGCTCCCCCTGCTGCAGTTGCTGCTACTGGTGGTGCAGG CCGTGGGGAGGGGGCTGGGCCGCGCCAGCCCGGCCGGGGGCCCCCTGGAAGATGTGGTCATCGAGAGGTACCACATCCCCAGGGCCTGTC CCCGGGAAGTGCAGATGGGGGATTTTGTGCGCTACCACTACAACGGCACTTTTGAAGATGGCAAGAAGTTTGATTCAAGCTATGATCGCA ACACCTTGGTGGCCATCGTGGTGGGTGTGGGGCGCCTCATCACTGGCATGGACCGAGGCCTCATGGGCATGTGTGTCAACGAGCGGCGAC GCCTCATTGTGCCTCCCCACCTGGGCTATGGGAGCATCGGCCTGGTGCCAAGACCCGACGCATTAGACAATGAGAGCTGGGGCTTTGTGC ACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGCTTT TCAAAAAGCAAAACCCAGGCAAGTTCTGCTTGCTGAGCTGTGGGATACTGACCTTTTTGGCTGTCTTGGGCCGCTACGTCCCTGGGCTTC TGCTGTCCTACTTGATGCTTGTCACTGTCATGATGTGGCCCCTTGCTGTGTACCACCGACTGTGGGATCGAGCATATGTGCGGCTGAAGC CAGCTCTGCAGCGGCTAGACTTCAGTGTCCGTGGCTACATGATGTCCAAGCAGAGAGAGAGACAATTACGCCGCAGAGCTCTCCACCCAG AACGAGCCATGGACAACCACAGTGACAGCGAAGAGGAGCTTGCTGCCTTCTGTCCTCAGCTGGACGATTCTACTGTTGCCAGGGAATTGG CCATCACAGACTCTGAGCACTCAGACGCTGAAGTCTCCTGTACAGACAATGGCACATTCAATCTTTCAAGGGGCCAAACACCTCTAACGG AAGGCTCTGAAGACCTAGATGGTCACAGTGATCCAGAGGAATCCTTTGCCAGAGACCTTCCAGACTTCCCTTCCATTAATATGGATCCTG CTGGCCTGGATGATGAGGACGACACTAGCATTGGCATGCCCAGCTTGATGTACCGTTCTCCGCCAGGGGCTGAGGAGCCCCAGGCCCCAC CTGCCAGCCGGGACGAGGCTGCGCTGCCGGAGCTCCTGCTTGGTGCTCTTCCTGTAGGATCCAACCTCACCAGCAACCTTGCCAGCCTGG TCTCCCAGGGTATGATTCAGCTGGCCTTGTCAGGGGCCTCCCAACCAGGCCCTTCTGGAGCACCTGCCCAGAGAGCAACGAGAGGCTTCC TCCGGTCCCCCAGTTCAGACCTGGACACTGATGCTGAGGGGGATGACTTTGAACTTCTGGACCAGTCGGAGCTGAGTCAGCTGGACCCTG CCAGTTCTAGGAGCCACTGAGGCAGAGACTCCTTTTGGGAGTCACTGTGGTTTAGGTTTTTTTCTCCCCATCCCACTTAAGGTGATGGGG CAAGGGAAGAACTCAGCTCCCCTCCCCTGAATTATATTTGTATGCTGGGTGGCCTGGCTGATGCTCAGAGGCCTCCTTAGAGAGGACACT CACTCCCCTCCCACCAGCTGGATGCCCATTTCTGAGCTCAGTCACTGAAGTGAGAGTGTGCTCCCCCAAGGGAGGCTTCTCTCCATCAGG ATGGTACTTTGGGGGAACAAAATAGTCAGGGATATTGGTTCCCCTTTGAGGAGGTGCTGCTGTTTGCTTTTAGGTATGAGTGCTCAGGGG CCCTCACTGAAAGAGCCCATGCCTGCCTTCCTCCTTTCATCGCCTCTCTAGAGCCCCCAAAGTCAGGCAGCAGCTGGAGTAGTTACATTG TCATCATCTTTTTTTTTGAGACAGTTTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTTTCTGCAACGTCTGCCTTCC AGGTTGAAGAGGTTCTCCTGCCTCAGCCTCCTTAGTAGTGGGATTACAGGTGCCCGCTACTATGCCCGGCTAATTTTTCTTTTGGTATTT TTAGTAGAAATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGAGCTGACTGCCTTGGCCTCCCAGAGTGCT GGGATTAGTCGTCATCTTTTGTTAAACCAGGATTTGATTTTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTTTTGAGACAGAGTCTCTCT CTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAGCCTCCGCCTGCCGGGTCAAGCGATTCTCCTACCTCAGCCTCCT CAGTAGCTGAGATTACAGGCATGCACCACCATGCCCGGCTAATTTTTTTGTGTTTTTAGTAGAGATGGGGTTTCACCGTGCTGGCCAGGC TGGTCTAGAACTCCTGACTGCAAATGATCAGCCCGCCTCAGCCACCCAAAGTGTTGGGATTACAGGTGTGAGCCACTGTGCCCAGCGTGA TTTTTTTTTTTTTTTAAAGCAAACTTGTCCTTTGGTTTTGCAGAACAGGCCTGCTCCCTCTCATCTAGCCCATCATTTCTTGGGGCCTGA ACCCCAGTGGTCCAAAGTATTGCTTGTGAAATTTAAAAAATGTGAATATGATGTGGGGATGGGCCTCTTCTACATTACCTTGGCCCAGGG GGATCAGCTGGCTGGGAGGATTAGTGAGCACCTCTGTATTTTGAGGTCTGAGTCTTCTGGAGCTGTGTAGTTAATCTTCGGTTTCTGATA ACCCCTGGGTCCATCTGGCCATCAGCCTCAGCAGTGAGCAAAGCAATACCATACTCATTTCTATGTTCCTGTTCCTTCCTCTGCTCCTCC TTTGGAGAAGCAATAATTCATGGGGGATGATACAGTAGCACTTTACAAATGGCTCCATGTCATTCATCCCAGGGGCCATAATCTCTTGCA CCACCTATTCTTACTTCCTGTTCAGCTCCTTTACAGCTTTTATTTTCAACTGCTTCCCAACTTGGTGGGGCCTCCTTTAAGGATGAGCCA ATAGTAAGAATGTGGCTGTAATCAGCAGAGACCCCTCTGAGGGGTATCTGTTCTGCAGCCCCTAGTGAAATCATGTGATGTGAGACAGAA ACCTAAACATGGTACTTGATTCTAAACCTGTGCCAGTCTATAGCCTCTGCCTCCCCAAGCAGAGCTCAAGCCAAACGCTTCTGTCCTCTT TCCTTCTGCATTAACCCTTTGCTGATCCTCAGGGGCCACTCCCCCAACACCCCTGTACTTGGGTGAGGGATGTTGGACAGAGCCTGTTTT CATGTACTGCAGGTGGGGGTGTGCTGACATGTTTGCTCTTGGTTGATGGAGAAGGTACAGAGGCCAGGGAGTGAAAATGGTTGACAGAAG AGGGAAGAGTTAGGTGTCTCATAGTCACTCATAGTGGGGTGGTCAGGGGTAATGGCATCTCCCCACTTTAGGCTTCTCAAACAGACTTTT GACACCTCTCAAGTTCAGAGCTCTGATGTGGAAAGACAGGAGGTGTGGGGAAGGAGGGGGATTTCGTGTGTTTGCATGAGTGTGCGCTTC AGGCCTTGGGAGTTGGCAAGAGGGAGGGAAGGAAGGAGAGCAAAATCTTCGGAAGGTGTTTCTTGTACCTGAGGGATCCTGCCCTGAATC >In-frame_ENST00000321562_ENST00000309428_TCGA-L5-A4OW_FKBP10_chr17_39973455_+_FAM134C_chr17_40739882_length(amino acids)=490AA_start in transcript=77_stop in transcript=1549 MPAVPTPGTMFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQMGDFVRYHYNGTFEDGKKFDS SYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGLVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIR NVLLFKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRERQLRRR ALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSI NMDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSNLTSNLASLVSQGMIQLALSGASQPGPSGAPAQRA -------------------------------------------------------------- >In-frame_ENST00000321562_ENST00000585894_TCGA-L5-A4OW_FKBP10_chr17_39973455_+_FAM134C_chr17_40739882_length(transcript)=2034nt_BP=495nt AGAGGACAGGAAGAGGGGGAGCCAGTTCTGGGAGGCGGGGGGAAGGAGGTTGGTGGCGACTCCCTCGCTCGCCCTCACTGCCGGCGGTCC CAACTCCAGGCACCATGTTCCCCGCGGGCCCCCCCAGCCACAGCCTCCTCCGGCTCCCCCTGCTGCAGTTGCTGCTACTGGTGGTGCAGG CCGTGGGGAGGGGGCTGGGCCGCGCCAGCCCGGCCGGGGGCCCCCTGGAAGATGTGGTCATCGAGAGGTACCACATCCCCAGGGCCTGTC CCCGGGAAGTGCAGATGGGGGATTTTGTGCGCTACCACTACAACGGCACTTTTGAAGATGGCAAGAAGTTTGATTCAAGCTATGATCGCA ACACCTTGGTGGCCATCGTGGTGGGTGTGGGGCGCCTCATCACTGGCATGGACCGAGGCCTCATGGGCATGTGTGTCAACGAGCGGCGAC GCCTCATTGTGCCTCCCCACCTGGGCTATGGGAGCATCGGCCTGGTGCCAAGACCCGACGCATTAGACAATGAGAGCTGGGGCTTTGTGC ACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGCTTT TCAAAAAGCAAAACCCAGGCAAGTTCTGCTTGCTGAGCTGTGGGATACTGACCTTTTTGGCTGTCTTGGGCCGCTACGTCCCTGGGCTTC TGCTGTCCTACTTGATGCTTGTCACTGTCATGATGTGGCCCCTTGCTGTGTACCACCGACTGTGGGATCGAGCATATGTGCGGCTGAAGC CAGCTCTGCAGCGGCTAGACTTCAGTGTCCGTGGCTACATGATGTCCAAGCAGAGAGAGAGACAATTACGCCGCAGAGCTCTCCACCCAG AACGAGCCATGGACAACCACAGTGACAGCGAAGAGGAGCTTGCTGCCTTCTGTCCTCAGCTGGACGATTCTACTGTTGCCAGGGAATTGG CCATCACAGACTCTGAGCACTCAGACGCTGAAGTCTCCTGTACAGACAATGGCACATTCAATCTTTCAAGGGGCCAAACACCTCTAACGG AAGGCTCTGAAGACCTAGATGGTCACAGTGATCCAGAGGAATCCTTTGCCAGAGACCTTCCAGACTTCCCTTCCATTAATATGGATCCTG CTGGCCTGGATGATGAGGACGACACTAGCATTGGCATGCCCAGCTTGATGTACCGTTCTCCGCCAGGGGCTGAGGAGCCCCAGGCCCCAC CTGCCAGCCGGGACGAGGCTGCGCTGCCGGAGCTCCTGCTTGGTGCTCTTCCTGTAGGATCCAACCTCACCAGCAACCTTGCCAGCCTGG TCTCCCAGGGTATGATTCAGCTGGCCTTGTCAGGGGCCTCCCAACCAGGCCCTTCTGGAGCACCTGCCCAGAGAGCAACGAGAGGCTTCC TCCGGTCCCCCAGTTCAGACCTGGACACTGATGCTGAGGGGGATGACTTTGAACTTCTGGACCAGTCGGAGCTGAGTCAGCTGGACCCTG CCAGTTCTAGGAGCCACTGAGGCAGAGACTCCTTTTGGGAGTCACTGTGGTTTAGGTTTTTTTCTCCCCATCCCACTTAAGGTGATGGGG CAAGGGAAGAACTCAGCTCCCCTCCCCTGAATTATATTTGTATGCTGGGTGGCCTGGCTGATGCTCAGAGGCCTCCTTAGAGAGGACACT CACTCCCCTCCCACCAGCTGGATGCCCATTTCTGAGCTCAGTCACTGAAGTGAGAGTGTGCTCCCCCAAGGGAGGCTTCTCTCCATCAGG ATGGTACTTTGGGGGAACAAAATAGTCAGGGATATTGGTTCCCCTTTGAGGAGGTGCTGCTGTTTGCTTTTAGGTATGAGTGCTCAGGGG CCCTCACTGAAAGAGCCCATGCCTGCCTTCCTCCTTTCATCGCCTCTCTAGAGCCCCCAAAGTCAGGCAGCAGCTGGAGTAGTTACATTG >In-frame_ENST00000321562_ENST00000585894_TCGA-L5-A4OW_FKBP10_chr17_39973455_+_FAM134C_chr17_40739882_length(amino acids)=490AA_start in transcript=77_stop in transcript=1549 MPAVPTPGTMFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQMGDFVRYHYNGTFEDGKKFDS SYDRNTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYGSIGLVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIR NVLLFKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRERQLRRR ALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSI NMDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSNLTSNLASLVSQGMIQLALSGASQPGPSGAPAQRA -------------------------------------------------------------- >In-frame_ENST00000321562_ENST00000309428_TCGA-L5-A4OW_FKBP10_chr17_39969531_+_FAM134C_chr17_40738909_length(transcript)=3671nt_BP=349nt AGAGGACAGGAAGAGGGGGAGCCAGTTCTGGGAGGCGGGGGGAAGGAGGTTGGTGGCGACTCCCTCGCTCGCCCTCACTGCCGGCGGTCC CAACTCCAGGCACCATGTTCCCCGCGGGCCCCCCCAGCCACAGCCTCCTCCGGCTCCCCCTGCTGCAGTTGCTGCTACTGGTGGTGCAGG CCGTGGGGAGGGGGCTGGGCCGCGCCAGCCCGGCCGGGGGCCCCCTGGAAGATGTGGTCATCGAGAGGTACCACATCCCCAGGGCCTGTC CCCGGGAAGTGCAGATGGGGGATTTTGTGCGCTACCACTACAACGGCACTTTTGAAGATGGCAAGAAGTTTGATTCAAGCTGGGGCTTTG TGCACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGC TTTTCAAAAAGCAAAACCCAGGCAAGTTCTGCTTGCTGAGCTGTGGGATACTGACCTTTTTGGCTGTCTTGGGCCGCTACGTCCCTGGGC TTCTGCTGTCCTACTTGATGCTTGTCACTGTCATGATGTGGCCCCTTGCTGTGTACCACCGACTGTGGGATCGAGCATATGTGCGGCTGA AGCCAGCTCTGCAGCGGCTAGACTTCAGTGTCCGTGGCTACATGATGTCCAAGCAGAGAGAGAGACAATTACGCCGCAGAGCTCTCCACC CAGAACGAGCCATGGACAACCACAGTGACAGCGAAGAGGAGCTTGCTGCCTTCTGTCCTCAGCTGGACGATTCTACTGTTGCCAGGGAAT TGGCCATCACAGACTCTGAGCACTCAGACGCTGAAGTCTCCTGTACAGACAATGGCACATTCAATCTTTCAAGGGGCCAAACACCTCTAA CGGAAGGCTCTGAAGACCTAGATGGTCACAGTGATCCAGAGGAATCCTTTGCCAGAGACCTTCCAGACTTCCCTTCCATTAATATGGATC CTGCTGGCCTGGATGATGAGGACGACACTAGCATTGGCATGCCCAGCTTGATGTACCGTTCTCCGCCAGGGGCTGAGGAGCCCCAGGCCC CACCTGCCAGCCGGGACGAGGCTGCGCTGCCGGAGCTCCTGCTTGGTGCTCTTCCTGTAGGATCCAACCTCACCAGCAACCTTGCCAGCC TGGTCTCCCAGGGTATGATTCAGCTGGCCTTGTCAGGGGCCTCCCAACCAGGCCCTTCTGGAGCACCTGCCCAGAGAGCAACGAGAGGCT TCCTCCGGTCCCCCAGTTCAGACCTGGACACTGATGCTGAGGGGGATGACTTTGAACTTCTGGACCAGTCGGAGCTGAGTCAGCTGGACC CTGCCAGTTCTAGGAGCCACTGAGGCAGAGACTCCTTTTGGGAGTCACTGTGGTTTAGGTTTTTTTCTCCCCATCCCACTTAAGGTGATG GGGCAAGGGAAGAACTCAGCTCCCCTCCCCTGAATTATATTTGTATGCTGGGTGGCCTGGCTGATGCTCAGAGGCCTCCTTAGAGAGGAC ACTCACTCCCCTCCCACCAGCTGGATGCCCATTTCTGAGCTCAGTCACTGAAGTGAGAGTGTGCTCCCCCAAGGGAGGCTTCTCTCCATC AGGATGGTACTTTGGGGGAACAAAATAGTCAGGGATATTGGTTCCCCTTTGAGGAGGTGCTGCTGTTTGCTTTTAGGTATGAGTGCTCAG GGGCCCTCACTGAAAGAGCCCATGCCTGCCTTCCTCCTTTCATCGCCTCTCTAGAGCCCCCAAAGTCAGGCAGCAGCTGGAGTAGTTACA TTGTCATCATCTTTTTTTTTGAGACAGTTTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTTTCTGCAACGTCTGCCT TCCAGGTTGAAGAGGTTCTCCTGCCTCAGCCTCCTTAGTAGTGGGATTACAGGTGCCCGCTACTATGCCCGGCTAATTTTTCTTTTGGTA TTTTTAGTAGAAATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGAGCTGACTGCCTTGGCCTCCCAGAGT GCTGGGATTAGTCGTCATCTTTTGTTAAACCAGGATTTGATTTTTTTCTTTTCTTTTCTTTTCTTTTTTTTTTTTTTGAGACAGAGTCTC TCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAGCCTCCGCCTGCCGGGTCAAGCGATTCTCCTACCTCAGCCT CCTCAGTAGCTGAGATTACAGGCATGCACCACCATGCCCGGCTAATTTTTTTGTGTTTTTAGTAGAGATGGGGTTTCACCGTGCTGGCCA GGCTGGTCTAGAACTCCTGACTGCAAATGATCAGCCCGCCTCAGCCACCCAAAGTGTTGGGATTACAGGTGTGAGCCACTGTGCCCAGCG TGATTTTTTTTTTTTTTTAAAGCAAACTTGTCCTTTGGTTTTGCAGAACAGGCCTGCTCCCTCTCATCTAGCCCATCATTTCTTGGGGCC TGAACCCCAGTGGTCCAAAGTATTGCTTGTGAAATTTAAAAAATGTGAATATGATGTGGGGATGGGCCTCTTCTACATTACCTTGGCCCA GGGGGATCAGCTGGCTGGGAGGATTAGTGAGCACCTCTGTATTTTGAGGTCTGAGTCTTCTGGAGCTGTGTAGTTAATCTTCGGTTTCTG ATAACCCCTGGGTCCATCTGGCCATCAGCCTCAGCAGTGAGCAAAGCAATACCATACTCATTTCTATGTTCCTGTTCCTTCCTCTGCTCC TCCTTTGGAGAAGCAATAATTCATGGGGGATGATACAGTAGCACTTTACAAATGGCTCCATGTCATTCATCCCAGGGGCCATAATCTCTT GCACCACCTATTCTTACTTCCTGTTCAGCTCCTTTACAGCTTTTATTTTCAACTGCTTCCCAACTTGGTGGGGCCTCCTTTAAGGATGAG CCAATAGTAAGAATGTGGCTGTAATCAGCAGAGACCCCTCTGAGGGGTATCTGTTCTGCAGCCCCTAGTGAAATCATGTGATGTGAGACA GAAACCTAAACATGGTACTTGATTCTAAACCTGTGCCAGTCTATAGCCTCTGCCTCCCCAAGCAGAGCTCAAGCCAAACGCTTCTGTCCT CTTTCCTTCTGCATTAACCCTTTGCTGATCCTCAGGGGCCACTCCCCCAACACCCCTGTACTTGGGTGAGGGATGTTGGACAGAGCCTGT TTTCATGTACTGCAGGTGGGGGTGTGCTGACATGTTTGCTCTTGGTTGATGGAGAAGGTACAGAGGCCAGGGAGTGAAAATGGTTGACAG AAGAGGGAAGAGTTAGGTGTCTCATAGTCACTCATAGTGGGGTGGTCAGGGGTAATGGCATCTCCCCACTTTAGGCTTCTCAAACAGACT TTTGACACCTCTCAAGTTCAGAGCTCTGATGTGGAAAGACAGGAGGTGTGGGGAAGGAGGGGGATTTCGTGTGTTTGCATGAGTGTGCGC TTCAGGCCTTGGGAGTTGGCAAGAGGGAGGGAAGGAAGGAGAGCAAAATCTTCGGAAGGTGTTTCTTGTACCTGAGGGATCCTGCCCTGA >In-frame_ENST00000321562_ENST00000309428_TCGA-L5-A4OW_FKBP10_chr17_39969531_+_FAM134C_chr17_40738909_length(amino acids)=431AA_start in transcript=77_stop in transcript=1372 MPAVPTPGTMFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQMGDFVRYHYNGTFEDGKKFDS SWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRA YVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRG QTPLTEGSEDLDGHSDPEESFARDLPDFPSINMDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSNLTS -------------------------------------------------------------- >In-frame_ENST00000321562_ENST00000585894_TCGA-L5-A4OW_FKBP10_chr17_39969531_+_FAM134C_chr17_40738909_length(transcript)=1857nt_BP=349nt AGAGGACAGGAAGAGGGGGAGCCAGTTCTGGGAGGCGGGGGGAAGGAGGTTGGTGGCGACTCCCTCGCTCGCCCTCACTGCCGGCGGTCC CAACTCCAGGCACCATGTTCCCCGCGGGCCCCCCCAGCCACAGCCTCCTCCGGCTCCCCCTGCTGCAGTTGCTGCTACTGGTGGTGCAGG CCGTGGGGAGGGGGCTGGGCCGCGCCAGCCCGGCCGGGGGCCCCCTGGAAGATGTGGTCATCGAGAGGTACCACATCCCCAGGGCCTGTC CCCGGGAAGTGCAGATGGGGGATTTTGTGCGCTACCACTACAACGGCACTTTTGAAGATGGCAAGAAGTTTGATTCAAGCTGGGGCTTTG TGCACCCTCGGTTGCTCAGCGTGCCCGAGCTCTGCCACCATGTAGCTGAAGTCTGGGTTAGTGGGACCATTTTCATAAGGAATGTTTTGC TTTTCAAAAAGCAAAACCCAGGCAAGTTCTGCTTGCTGAGCTGTGGGATACTGACCTTTTTGGCTGTCTTGGGCCGCTACGTCCCTGGGC TTCTGCTGTCCTACTTGATGCTTGTCACTGTCATGATGTGGCCCCTTGCTGTGTACCACCGACTGTGGGATCGAGCATATGTGCGGCTGA AGCCAGCTCTGCAGCGGCTAGACTTCAGTGTCCGTGGCTACATGATGTCCAAGCAGAGAGAGAGACAATTACGCCGCAGAGCTCTCCACC CAGAACGAGCCATGGACAACCACAGTGACAGCGAAGAGGAGCTTGCTGCCTTCTGTCCTCAGCTGGACGATTCTACTGTTGCCAGGGAAT TGGCCATCACAGACTCTGAGCACTCAGACGCTGAAGTCTCCTGTACAGACAATGGCACATTCAATCTTTCAAGGGGCCAAACACCTCTAA CGGAAGGCTCTGAAGACCTAGATGGTCACAGTGATCCAGAGGAATCCTTTGCCAGAGACCTTCCAGACTTCCCTTCCATTAATATGGATC CTGCTGGCCTGGATGATGAGGACGACACTAGCATTGGCATGCCCAGCTTGATGTACCGTTCTCCGCCAGGGGCTGAGGAGCCCCAGGCCC CACCTGCCAGCCGGGACGAGGCTGCGCTGCCGGAGCTCCTGCTTGGTGCTCTTCCTGTAGGATCCAACCTCACCAGCAACCTTGCCAGCC TGGTCTCCCAGGGTATGATTCAGCTGGCCTTGTCAGGGGCCTCCCAACCAGGCCCTTCTGGAGCACCTGCCCAGAGAGCAACGAGAGGCT TCCTCCGGTCCCCCAGTTCAGACCTGGACACTGATGCTGAGGGGGATGACTTTGAACTTCTGGACCAGTCGGAGCTGAGTCAGCTGGACC CTGCCAGTTCTAGGAGCCACTGAGGCAGAGACTCCTTTTGGGAGTCACTGTGGTTTAGGTTTTTTTCTCCCCATCCCACTTAAGGTGATG GGGCAAGGGAAGAACTCAGCTCCCCTCCCCTGAATTATATTTGTATGCTGGGTGGCCTGGCTGATGCTCAGAGGCCTCCTTAGAGAGGAC ACTCACTCCCCTCCCACCAGCTGGATGCCCATTTCTGAGCTCAGTCACTGAAGTGAGAGTGTGCTCCCCCAAGGGAGGCTTCTCTCCATC AGGATGGTACTTTGGGGGAACAAAATAGTCAGGGATATTGGTTCCCCTTTGAGGAGGTGCTGCTGTTTGCTTTTAGGTATGAGTGCTCAG GGGCCCTCACTGAAAGAGCCCATGCCTGCCTTCCTCCTTTCATCGCCTCTCTAGAGCCCCCAAAGTCAGGCAGCAGCTGGAGTAGTTACA >In-frame_ENST00000321562_ENST00000585894_TCGA-L5-A4OW_FKBP10_chr17_39969531_+_FAM134C_chr17_40738909_length(amino acids)=431AA_start in transcript=77_stop in transcript=1372 MPAVPTPGTMFPAGPPSHSLLRLPLLQLLLLVVQAVGRGLGRASPAGGPLEDVVIERYHIPRACPREVQMGDFVRYHYNGTFEDGKKFDS SWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRA YVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRG QTPLTEGSEDLDGHSDPEESFARDLPDFPSINMDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSNLTS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FKBP10-FAM134C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FKBP10-FAM134C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FKBP10-FAM134C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FKBP10 | C1850168 | Bruck syndrome 1 | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | FKBP10 | C0432253 | Bruck syndrome | 3 | ORPHANET |
| Hgene | FKBP10 | C1836602 | Bruck syndrome 2 | 3 | ORPHANET |
| Hgene | FKBP10 | C0268362 | Osteogenesis imperfecta type III (disorder) | 2 | ORPHANET |
| Hgene | FKBP10 | C0268363 | Osteogenesis imperfecta type IV (disorder) | 2 | ORPHANET |
| Hgene | FKBP10 | C1859709 | Kuskokwim disease | 1 | ORPHANET |
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