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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FMN1-AVEN (FusionGDB2 ID:30625)

Fusion Gene Summary for FMN1-AVEN

check button Fusion gene summary
Fusion gene informationFusion gene name: FMN1-AVEN
Fusion gene ID: 30625
HgeneTgene
Gene symbol

FMN1

AVEN

Gene ID

342184

57099

Gene nameformin 1apoptosis and caspase activation inhibitor
SynonymsFMN|LDPDCD12
Cytomap

15q13.3

15q14

Type of geneprotein-codingprotein-coding
Descriptionformin-1formin (limb deformity)limb deformity protein homologcell death regulator Avenapoptosis, caspase activation inhibitorprogrammed cell death 12
Modification date2020031320200313
UniProtAcc

Q68DA7

Q9NQS1

Ensembl transtripts involved in fusion geneENST00000334528, ENST00000561249, 
ENST00000559047, ENST00000558197, 
ENST00000559150, ENST00000320930, 
ENST00000306730, ENST00000558136, 
Fusion gene scores* DoF score11 X 9 X 5=4955 X 3 X 5=75
# samples 125
** MAII scorelog2(12/495*10)=-2.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FMN1 [Title/Abstract] AND AVEN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFMN1(33091005)-AVEN(34168196), # samples:3
Anticipated loss of major functional domain due to fusion event.FMN1-AVEN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FMN1-AVEN seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAVEN

GO:0043066

negative regulation of apoptotic process

10949025


check buttonFusion gene breakpoints across FMN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AVEN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A5GL-06AFMN1chr15

33091005

-AVENchr15

34168196

-
ChimerDB4SKCMTCGA-D3-A5GL-06AFMN1chr15

33091005

-AVENchr15

34168196

-
ChimerDB4SKCMTCGA-D3-A5GL-06AFMN1chr15

33149216

-AVENchr15

34168196

-
ChimerDB4SKCMTCGA-D3-A5GL-06AFMN1chr15

33091005

-AVENchr15

34168196

-


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Fusion Gene ORF analysis for FMN1-AVEN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000334528ENST00000306730FMN1chr15

33091005

-AVENchr15

34168196

-
5CDS-5UTRENST00000334528ENST00000558136FMN1chr15

33091005

-AVENchr15

34168196

-
Frame-shiftENST00000561249ENST00000306730FMN1chr15

33091005

-AVENchr15

34168196

-
5CDS-5UTRENST00000561249ENST00000558136FMN1chr15

33091005

-AVENchr15

34168196

-
Frame-shiftENST00000559047ENST00000306730FMN1chr15

33091005

-AVENchr15

34168196

-
5CDS-5UTRENST00000559047ENST00000558136FMN1chr15

33091005

-AVENchr15

34168196

-
intron-3CDSENST00000558197ENST00000306730FMN1chr15

33091005

-AVENchr15

34168196

-
intron-5UTRENST00000558197ENST00000558136FMN1chr15

33091005

-AVENchr15

34168196

-
intron-3CDSENST00000559150ENST00000306730FMN1chr15

33091005

-AVENchr15

34168196

-
intron-5UTRENST00000559150ENST00000558136FMN1chr15

33091005

-AVENchr15

34168196

-
intron-3CDSENST00000320930ENST00000306730FMN1chr15

33091005

-AVENchr15

34168196

-
intron-5UTRENST00000320930ENST00000558136FMN1chr15

33091005

-AVENchr15

34168196

-
In-frameENST00000334528ENST00000306730FMN1chr15

33149216

-AVENchr15

34168196

-
5CDS-5UTRENST00000334528ENST00000558136FMN1chr15

33149216

-AVENchr15

34168196

-
In-frameENST00000561249ENST00000306730FMN1chr15

33149216

-AVENchr15

34168196

-
5CDS-5UTRENST00000561249ENST00000558136FMN1chr15

33149216

-AVENchr15

34168196

-
In-frameENST00000559047ENST00000306730FMN1chr15

33149216

-AVENchr15

34168196

-
5CDS-5UTRENST00000559047ENST00000558136FMN1chr15

33149216

-AVENchr15

34168196

-
intron-3CDSENST00000558197ENST00000306730FMN1chr15

33149216

-AVENchr15

34168196

-
intron-5UTRENST00000558197ENST00000558136FMN1chr15

33149216

-AVENchr15

34168196

-
intron-3CDSENST00000559150ENST00000306730FMN1chr15

33149216

-AVENchr15

34168196

-
intron-5UTRENST00000559150ENST00000558136FMN1chr15

33149216

-AVENchr15

34168196

-
intron-3CDSENST00000320930ENST00000306730FMN1chr15

33149216

-AVENchr15

34168196

-
intron-5UTRENST00000320930ENST00000558136FMN1chr15

33149216

-AVENchr15

34168196

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334528FMN1chr1533149216-ENST00000306730AVENchr1534168196-42893259039021300
ENST00000561249FMN1chr1533149216-ENST00000306730AVENchr1534168196-4790376012644031425
ENST00000559047FMN1chr1533149216-ENST00000306730AVENchr1534168196-49583928045711523

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334528ENST00000306730FMN1chr1533149216-AVENchr1534168196-0.0005475330.9994524
ENST00000561249ENST00000306730FMN1chr1533149216-AVENchr1534168196-0.0013274440.9986726
ENST00000559047ENST00000306730FMN1chr1533149216-AVENchr1534168196-0.0009355760.9990644

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Fusion Genomic Features for FMN1-AVEN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FMN1-AVEN


check button Go to

FGviewer for the breakpoints of chr15:33149216-chr15:34168196

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FMN1

Q68DA7

AVEN

Q9NQS1

FUNCTION: Plays a role in the formation of adherens junction and the polymerization of linear actin cables. {ECO:0000250}.FUNCTION: Protects against apoptosis mediated by Apaf-1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFMN1chr15:33149216chr15:34168196ENST00000334528-1317720_7741086.33333333333331197.0Coiled coilOntology_term=ECO:0000255
HgeneFMN1chr15:33149216chr15:34168196ENST00000559047-1418720_7741309.33333333333331420.0Coiled coilOntology_term=ECO:0000255
HgeneFMN1chr15:33149216chr15:34168196ENST00000334528-1317869_9841086.33333333333331197.0Compositional biasNote=Pro-rich
HgeneFMN1chr15:33149216chr15:34168196ENST00000559047-1418869_9841309.33333333333331420.0Compositional biasNote=Pro-rich
HgeneFMN1chr15:33149216chr15:34168196ENST00000334528-1317870_9571086.33333333333331197.0DomainNote=FH1
HgeneFMN1chr15:33149216chr15:34168196ENST00000559047-1418870_9571309.33333333333331420.0DomainNote=FH1
HgeneFMN1chr15:33149216chr15:34168196ENST00000334528-13171_6221086.33333333333331197.0RegionMicrotubule-binding
HgeneFMN1chr15:33149216chr15:34168196ENST00000559047-14181_6221309.33333333333331420.0RegionMicrotubule-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFMN1chr15:33149216chr15:34168196ENST00000320930-15720_7740663.0Coiled coilOntology_term=ECO:0000255
HgeneFMN1chr15:33149216chr15:34168196ENST00000558197-12720_7740504.0Coiled coilOntology_term=ECO:0000255
HgeneFMN1chr15:33149216chr15:34168196ENST00000320930-15869_9840663.0Compositional biasNote=Pro-rich
HgeneFMN1chr15:33149216chr15:34168196ENST00000558197-12869_9840504.0Compositional biasNote=Pro-rich
HgeneFMN1chr15:33149216chr15:34168196ENST00000320930-15870_9570663.0DomainNote=FH1
HgeneFMN1chr15:33149216chr15:34168196ENST00000320930-15972_13880663.0DomainFH2
HgeneFMN1chr15:33149216chr15:34168196ENST00000334528-1317972_13881086.33333333333331197.0DomainFH2
HgeneFMN1chr15:33149216chr15:34168196ENST00000558197-12870_9570504.0DomainNote=FH1
HgeneFMN1chr15:33149216chr15:34168196ENST00000558197-12972_13880504.0DomainFH2
HgeneFMN1chr15:33149216chr15:34168196ENST00000559047-1418972_13881309.33333333333331420.0DomainFH2
HgeneFMN1chr15:33149216chr15:34168196ENST00000320930-151_6220663.0RegionMicrotubule-binding
HgeneFMN1chr15:33149216chr15:34168196ENST00000558197-121_6220504.0RegionMicrotubule-binding
TgeneAVENchr15:33149216chr15:34168196ENST00000306730165_85148.33333333333334363.0Compositional biasNote=Ala/Gly-rich


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Fusion Gene Sequence for FMN1-AVEN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000334528_ENST00000306730_TCGA-D3-A5GL-06A_FMN1_chr15_33149216_-_AVEN_chr15_34168196_length(transcript)=4289nt_BP=3259nt
ATGGAGAACGTTGATAATTCTCTGGATGGCAGTGATGTGTCAGAACCAGCAAAACCAGAAGCCGGACTTGAAGTGGCTCAGTCGATCCTG
AGTAAGTTCTCTATGAAATCCCTATTTGGGTTTACGAGTAAATTAGAATCTGTGAATCCAGAAGAGGAAGATGCTGTGCTGAAAGCATTC
CATAGTTTAGACGTGAATCCCACATCTCAGCAGGATGATTCCAGCAATGGCTTGGATCCACAGGAAGCAGGGTCTCGGGTTTCACCTGAC
CTCGGAAATGATGAGAAAATTGCAAGCGTGGAGACAGAATCAGAGGGAAGTCAGAGAAAAGAAGCAGGGACATCTCTCCTTGCTCAAGAG
CTGCTTCCACTGTCTACTTTGAAAGGGACAAAAGACGATGTCATTTGTGTTCGTGGGACCCTGGTGCACACCACCAGTGATTCTGACTCT
GATGATGGTGGCCAGGAGCCAGAGGAGGGAAGCAGCACCAATGGCCCAAAGTCCCCTAGTGGTGTTTTATCTGAGCCATCTCAGGAGTCC
AAAGAAAACCCAGGAGGTTTCAGGGAAAATACTGTCACTGGGGAAATGAATGGTGCAGAGCTCTGTGCAGAAGATCCTCAAAGGATTCCA
CCTGAGATGAGCAGCAAACTGGAAGCTGGCAACGGTGGTCTTCAGACAGAGCGTCGCCCCAGCCAGGACCAGGTGGGAGAAGAAGGGTCC
CAAGACCTACCTGCAGTAACAAACCAGAATTCGAGTGTTGGTATCACTGAGAGTGCCTCTTCTAAAAAAGAAGTCTCTGGAGAGAAGTCA
TTCCAACTTCCAGCTTTTTTCAGTGGGCTTCGTGTGCTGAAGAAGGGGGCTACCGCTGAGGGAGGAGAGACCATCACGGAAATTAAACCA
AAGGATGGGGACTTAGCTTTGCTCAAATTGACGCAGCCTGTGCAGAAGTCCTTAGTGCAGGCAGGGCTGCAGACAGTGAAGAGTGAGAAG
AAAGCAACTGATCCGAAGGCCACTCCCACTCTCCTGGAGCAGCTCTCTCTGCTGCTCAACATTGACATGCCCAAAACTGAACCGAAGGGA
GCAGACCCTGAGTCGCCCAGGAGAGAAGAGATGGGCTGCAATGCTGACCAAGAGAGCCAGAGCGGCCCTGGAGTACCACAAACCCAGGGT
GGTGAGGTCAAGCCAAAGTCGCCAGAGACAGCCCTGGAGGCTTTTAAAGCCCTATTCATCCGGCCCCCCAGAAAGGGGACCACAGCTGAC
ACCTCTGAGCTGGAAGCTCTCAAGCGCAAGATGAGACATGAGAAGGAGTCGCTAAGAGCTGTGTTTGAACGGTCCAATTCTAAGCCAGCG
GATGGCCCCTCTGATTCCAAAAGTCCTGACCACAGCCTGACTGAGCAGGATGACAGGACTCCTGGCAGACTTCAAGCTGTCTGGCCACCC
CCAAAGACAAAAGACACAGAAGAAAAAGTGGGACTGAAGTACACTGAAGCAGAATACCAAGCTGCTATTTTACACTTGAAGAGGGAGCAC
AAAGAAGAAATTGAAAACCTGCAGGCACAGTTTGAACTTCGGGCATTTCATATCCGGGGCGAGCATGCAATGATAACAGCGAGACTAGAA
GAAACCATTGAAAATCTGAAACACGAGCTAGAACACAGATGGCGAGGGGGTTGTGAAGAGAGGAAAGATGTGTGCATTTCCACCGATGAT
GACTGCCCTCCAAAGACCTTCAGAAATGTGTGCGTCCAGACAGACAGAGAGACCTTCCTCAAGCCCTGTGAAAGTGAAAGCAAGACAACC
AGAAGTAATCAATTAGTACCCAAAAAGCTGAATATCTCCTCTTTAAGCCAGCTCTCACCCCCAAATGACCACAAAGACATCCATGCAGCA
CTCCAGCCAATGGAGGGCATGGCATCAAATCAGCAGAAGGCATTGCCTCCGCCTCCCGCATCCATCCCTCCCCCTCCGCCCCTCCCCTCA
GGACTTGGATCTTTGTCTCCCGCACCTCCAATGCCACCTGTGAGTGCTGGGCCACCGCTACCACCTCCGCCTCCTCCACCGCCACCTCTA
CCTCCACCTTCAAGTGCTGGACCTCCACCACCCCCACCCCCACCCCCACTTCCTAACTCCCCTGCCCCACCCAACCCTGGAGGGCCTCCT
CCTGCTCCACCACCCCCAGGACTTGCACCCCCACCTCCCCCTGGACTCTTCTTTGGACTTGGCTCTTCTTCCAGTCAATGTCCTCGAAAA
CCAGCCATCGAGCCCAGTTGTCCCATGAAGCCTTTATATTGGACTAGGATACAAATAAGTGATAGGAGCCAAAATGCTACACCAACCTTA
TGGGACTCCTTAGAAGAACCTGACATTCGGGACCCCAGTGAATTTGAGTATTTATTCTCCAAAGACACAACTCAACAGAAGAAAAAACCT
CTGTCAGAGACTTATGAGAAGAAAAACAAGGTCAAAAAGATCATCAAATTGTTGGATGGAAAACGATCTCAAACTGTGGGAATCTTGATA
TCTAGTTTACATTTAGAAATGAAGGATATCCAACAGGCCATTTTCAATGTGGATGACTCCGTGGTTGATCTGGAGACCCTGGCAGCCTTA
TATGAAAACAGAGCCCAAGAGGATGAGCTGGTTAAAATAAGAAAGTATTACGAGACATCCAAAGAAGAAGAACTGAAGCTGCTGGATAAA
CCTGAGCAATTTTTACATGAGTTAGCCCAGATTCCTAATTTTGCTGAACGTGCCCAGTGCATAATCTTCAGATCTGTCTTTTCTGAGGGT
ATCACCTCCTTGCACAGAAAGGTAGAGATCATCACGCGAGCTTCTAAGGACTTGCTGCACGTGAAGAGCGTGAAGGATATTTTAGCTCTC
ATCTTGGCTTTTGGAAATTATATGAATGGAGGAAATAGGACTCGGGGACAAGCCGATGGATATAGCTTAGAAATTCTGCCCAAACTCAAG
GATGTCAAAAGTCGGGATAATGGGATTAATCTGGTGGACTACGTTGTTAAGTATTACCTGCGTTACTATGATCAGGAAGCTGGAACAGAA
AAGAGTGTTTTCCCCTTGCCGGAACCACAGGATTTCTTTCTGGCCTCCCAAGTCAAGTTTGAAGACCTCATAAAAGATTTGAGAAAACTG
AAGAGGCAACTAGAAGCAAGTGAGAAACAGATGGTGGTGGTGTGCAAGGAGTCCCCAAAGGAGTATCTCCAGCCTTTCAAGGACAAACTA
GAGGAGTTCTTCCAAAAAGGGGACTCATTCTCACAGTTCCGGTTTGCTGAGGAGAAAGAATGGGATAGTGAAGCTTCTTGTCCAAAACAG
AATTCAGCATTTTATGTGGATAGTGAGTTATTGGTTCGAGCCCTTCAAGAGCTGCCTCTCTGCCTCCGACTCAACGTTGCTGCCGAACTG
GTCCAGGGTACAGTTCCTTTAGAGGTTCCTCAGGTGAAACCAAAGAGAACTGATGATGGCAAGGGATTAGGGATGCAGTTAAAGGGGCCC
TTGGGGCCTGGAGGAAGGGGGCCCATCTTTGAGCTGAAATCTGTGGCTGCTGGCTGCCCTGTGTTGCTGGGCAAAGACAACCCAAGCCCG
GGTCCTTCAAGGGATTCTCAGAAACCCACTTCCCCACTGCAGTCAGCAGGAGACCATTTGGAAGAAGAACTAGATCTGTTGCTTAATTTA
GATGCACCTATAAAAGAGGGAGATAACATCTTACCAGATCAGACGTCTCAGGACCTGAAATCCAAGGAAGATGGGGAGGTGGTCCAAGAG
GAAGAAGTTTGTGCAAAACCATCTGTGACTGAAGAAAAAAACATGGAACCTGAGCAACCAAGTACCTCCAAAAATGTTACCGAGGAAGAG
CTGGAAGACTGGTTGGACAGCATGATTTCCTAAAAAGGGGAAAAAAAGTGCCTGAAGCAAATCTTGGTTGCCTTCTAACGGCAGGTGGGC
ATAAGGCTGTCCTTCAGGACCAGCCAGTTTACAAGCATGTCTCAAGCTAGTGTGTTCCATTATGCTCACAGCAGTAAATGCCTACCTCTG
TGTTTGACATCTGAAAGAATACATTGAAGCAGCTTGTTGCATTTGTTTTTCTGGCTTAGTAATCTAATAGATTTCCTTAAGGGCAGGAGA
TAGACTCTGGCCCTTGTTTCTAGCCTCCTTCCTTGCAGTGTTTACAACATAGCCAGTGTTTACAGCATAGCAGATGCTGCTGCTGATTAA

>In-frame_ENST00000334528_ENST00000306730_TCGA-D3-A5GL-06A_FMN1_chr15_33149216_-_AVEN_chr15_34168196_length(amino acids)=1300AA_start in transcript=0_stop in transcript=3902
MENVDNSLDGSDVSEPAKPEAGLEVAQSILSKFSMKSLFGFTSKLESVNPEEEDAVLKAFHSLDVNPTSQQDDSSNGLDPQEAGSRVSPD
LGNDEKIASVETESEGSQRKEAGTSLLAQELLPLSTLKGTKDDVICVRGTLVHTTSDSDSDDGGQEPEEGSSTNGPKSPSGVLSEPSQES
KENPGGFRENTVTGEMNGAELCAEDPQRIPPEMSSKLEAGNGGLQTERRPSQDQVGEEGSQDLPAVTNQNSSVGITESASSKKEVSGEKS
FQLPAFFSGLRVLKKGATAEGGETITEIKPKDGDLALLKLTQPVQKSLVQAGLQTVKSEKKATDPKATPTLLEQLSLLLNIDMPKTEPKG
ADPESPRREEMGCNADQESQSGPGVPQTQGGEVKPKSPETALEAFKALFIRPPRKGTTADTSELEALKRKMRHEKESLRAVFERSNSKPA
DGPSDSKSPDHSLTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEAEYQAAILHLKREHKEEIENLQAQFELRAFHIRGEHAMITARLE
ETIENLKHELEHRWRGGCEERKDVCISTDDDCPPKTFRNVCVQTDRETFLKPCESESKTTRSNQLVPKKLNISSLSQLSPPNDHKDIHAA
LQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPP
PAPPPPGLAPPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKKKP
LSETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDK
PEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLK
DVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKL
EEFFQKGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGP
LGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQE

--------------------------------------------------------------
>In-frame_ENST00000561249_ENST00000306730_TCGA-D3-A5GL-06A_FMN1_chr15_33149216_-_AVEN_chr15_34168196_length(transcript)=4790nt_BP=3760nt
CTCATTGCTGGAGATGACTGTCAGCTGCTTTCTCTGCATAGCCACCATCACATGCCTCACCACTGGAGCCTGGGAAGCCTGACCACAAAC
CGGCATCTCCAAGGCATGAATAATTAGGTAGGCATAATGGAAGGCACTCATTGTACCCTCCAATTGCATAAGCCCATTACGGAACTCTGC
TACATCAGCTTCTGTCTTCCAAAGGGGGAAGTCAGAGGATTTTCATACAAGGGCACTGTAACTCTAGACAGATCCAATAAAGGTTTTCAT
AACTGCTACCAAGTCAGGGAGGAGTCAGACATCATCAGCCTCAGCCAGGAGCCGGACGAACATCCAGGCGACATATTTTTCAAGCAGACT
CCCACGAAAGACATTCTAACTGAGCTGTACAAACTCACAACAGAGAGGGAGAGACTGCTAACCAATCTCCTGAGCTCAGACCACATCCTG
GGGATCACGATGGGGAACCAGGAGGGGAAGCTGCAAGAGCTGTCCGTGAGCCTGGCCCCCGAGGATGACTGTTTCCAGAGTGCTGGTGAC
TGGCAGGGAGAGCTCCCCGTGGGCCCTCTCAATAAGAGGAGCACCCACGGGAACAAAAAGCCTCGGAGGTCTAGTGGAAGGAGAGAGAGC
TTTGGGGCCCTTCCACAGAAGAGGACCAAAAGAAAAGGGCGTGGAGGCCGAGAATCAGCTCCTCTGATGGGCAAGGACAAGATCTGTTCC
AGCCACTCCCTTCCTCTTTCTAGAACAAGGCCTAACCTTTGGGTACTAGAGGAGAAAGGAAATCTGCTCCCGAATGGGGCACTTGCCTGC
TCCCTGCAGAGGAGAGAGAGCTGCCCCCCAGATATTCCCAAGACGCCAGACACAGACCTTGGCTTTGGGAGCTTTGAGACGGCTTTCAAG
GACACTGGGCTTGGAAGAGAAGTGCTGCCCCCTGACTGCAGCTCCACAGAGGCAGGAGGGGATGGCATTCGGAGGCCGCCGAGCGGGCTG
GAGCATCAGCAAACAGGTTTGTCTGAAAGTCACCAGGACCCTGAGAAGCATCCAGAGGCAGAAAAGGATGAGATGGAGAAGCCGGCTAAG
CGGACTTGCAAGCAGAAACCTGTCTCCAAAGTGGTGGCCAAAGTTCAGGACCTGTCCTCCCAGGTACAAAGAGTAGTTAAAACGCATTCT
AAGGGTAAGGAGACGATTGCCATTCGCCCAGCAGCCCACGCTGAGTTTGTACCCAAAGCCGACTTGCTCACCCTCCCGGGAGCTGAGGCT
GGGGCTCATGGCTCCAGGCGGCAGGGCAAGGAGCGGCAAGGGGATAGGTCATCGCAGTCGCCAGCCGGGGAAACAGCCTCCATTTCTAGT
GTGTCGGCCAGTGCCGAGGGGGCCGTGAACAAGGTCCCCCTGAAGGTGATAGAGAGTGAGAAGTTAGATGAAGCCCCTGAGGGGAAAAGA
CTGGGCTTCCCTGTCCACACGAGTGTCCCTCACACTCGCCCAGAAACGAGAAACAAGAGGAGAGCCGGGTTGCCCCTTGGTGGCCACAAG
TCCTTGTTTCTGGATCTGCCCCACAAAGTAGGTCCTGACTCCTCACAACCCAGAGGTGATAAGAAGAAGCCATCCCCACCAGCACCGGCA
GCTCTTGGCAAGGTGTTTAATAATTCAGCCTCGCAGTCCAGCACACACAAACAGACGTCACCTGTTCCCTCGCCTCTGTCTCCAAGGCTC
CCCAGCCCTCAGCAGCATCACAGGATCCTCCGGCTCCCTGCATTGCCTGGTGAGAGGGAAGCTGCTCTTAATGACTCTCCTTGTAGAAAG
AGCCGTGTCTTCTCTGGGTGCGTCTCTGCTGACACCTTGGAGCCACCATCCTCTGCAAAGGTCACGGAGACCAAAGGAGCCAGCCCGGCC
TTCCTCAGAGCAGGCCAACCTCGGTTGGTGCCTGGGGAAACTTTGGAAAAGAGCTTGGGGCCAGGGAAGACCACAGCTGAGCCCCAGCAC
CAGTCACCTCCAGAATACCAAGCTGCTATTTTACACTTGAAGAGGGAGCACAAAGAAGAAATTGAAAACCTGCAGGCACAGTTTGAACTT
CGGGCATTTCATATCCGGGGCGAGCATGCAATGATAACAGCGAGACTAGAAGAAACCATTGAAAATCTGAAACACGAGCTAGAACACAGA
TGGCGAGGGGGTTGTGAAGAGAGGAAAGATGTGTGCATTTCCACCGATGATGACTGCCCTCCAAAGACCTTCAGAAATGTGTGCGTCCAG
ACAGACAGAGAGACCTTCCTCAAGCCCTGTGAAAGTGAAAGCAAGACAACCAGAAGTAATCAATTAGTACCCAAAAAGCTGAATATCTCC
TCTTTAAGCCAGCTCTCACCCCCAAATGACCACAAAGACATCCATGCAGCACTCCAGCCAATGGAGGGCATGGCATCAAATCAGCAGAAG
GCATTGCCTCCGCCTCCCGCATCCATCCCTCCCCCTCCGCCCCTCCCCTCAGGACTTGGATCTTTGTCTCCCGCACCTCCAATGCCACCT
GTGAGTGCTGGGCCACCGCTACCACCTCCGCCTCCTCCACCGCCACCTCTACCTCCACCTTCAAGTGCTGGACCTCCACCACCCCCACCC
CCACCCCCACTTCCTAACTCCCCTGCCCCACCCAACCCTGGAGGGCCTCCTCCTGCTCCACCACCCCCAGGACTTGCACCCCCACCTCCC
CCTGGACTCTTCTTTGGACTTGGCTCTTCTTCCAGTCAATGTCCTCGAAAACCAGCCATCGAGCCCAGTTGTCCCATGAAGCCTTTATAT
TGGACTAGGATACAAATAAGTGATAGGAGCCAAAATGCTACACCAACCTTATGGGACTCCTTAGAAGAACCTGACATTCGGGACCCCAGT
GAATTTGAGTATTTATTCTCCAAAGACACAACTCAACAGAAGAAAAAACCTCTGTCAGAGACTTATGAGAAGAAAAACAAGGTCAAAAAG
ATCATCAAATTGTTGGATGGAAAACGATCTCAAACTGTGGGAATCTTGATATCTAGTTTACATTTAGAAATGAAGGATATCCAACAGGCC
ATTTTCAATGTGGATGACTCCGTGGTTGATCTGGAGACCCTGGCAGCCTTATATGAAAACAGAGCCCAAGAGGATGAGCTGGTTAAAATA
AGAAAGTATTACGAGACATCCAAAGAAGAAGAACTGAAGCTGCTGGATAAACCTGAGCAATTTTTACATGAGTTAGCCCAGATTCCTAAT
TTTGCTGAACGTGCCCAGTGCATAATCTTCAGATCTGTCTTTTCTGAGGGTATCACCTCCTTGCACAGAAAGGTAGAGATCATCACGCGA
GCTTCTAAGGACTTGCTGCACGTGAAGAGCGTGAAGGATATTTTAGCTCTCATCTTGGCTTTTGGAAATTATATGAATGGAGGAAATAGG
ACTCGGGGACAAGCCGATGGATATAGCTTAGAAATTCTGCCCAAACTCAAGGATGTCAAAAGTCGGGATAATGGGATTAATCTGGTGGAC
TACGTTGTTAAGTATTACCTGCGTTACTATGATCAGGAAGCTGGAACAGAAAAGAGTGTTTTCCCCTTGCCGGAACCACAGGATTTCTTT
CTGGCCTCCCAAGTCAAGTTTGAAGACCTCATAAAAGATTTGAGAAAACTGAAGAGGCAACTAGAAGCAAGTGAGAAACAGATGGTGGTG
GTGTGCAAGGAGTCCCCAAAGGAGTATCTCCAGCCTTTCAAGGACAAACTAGAGGAGTTCTTCCAAAAAGGGGACTCATTCTCACAGTTC
CGGTTTGCTGAGGAGAAAGAATGGGATAGTGAAGCTTCTTGTCCAAAACAGAATTCAGCATTTTATGTGGATAGTGAGTTATTGGTTCGA
GCCCTTCAAGAGCTGCCTCTCTGCCTCCGACTCAACGTTGCTGCCGAACTGGTCCAGGGTACAGTTCCTTTAGAGGTTCCTCAGGTGAAA
CCAAAGAGAACTGATGATGGCAAGGGATTAGGGATGCAGTTAAAGGGGCCCTTGGGGCCTGGAGGAAGGGGGCCCATCTTTGAGCTGAAA
TCTGTGGCTGCTGGCTGCCCTGTGTTGCTGGGCAAAGACAACCCAAGCCCGGGTCCTTCAAGGGATTCTCAGAAACCCACTTCCCCACTG
CAGTCAGCAGGAGACCATTTGGAAGAAGAACTAGATCTGTTGCTTAATTTAGATGCACCTATAAAAGAGGGAGATAACATCTTACCAGAT
CAGACGTCTCAGGACCTGAAATCCAAGGAAGATGGGGAGGTGGTCCAAGAGGAAGAAGTTTGTGCAAAACCATCTGTGACTGAAGAAAAA
AACATGGAACCTGAGCAACCAAGTACCTCCAAAAATGTTACCGAGGAAGAGCTGGAAGACTGGTTGGACAGCATGATTTCCTAAAAAGGG
GAAAAAAAGTGCCTGAAGCAAATCTTGGTTGCCTTCTAACGGCAGGTGGGCATAAGGCTGTCCTTCAGGACCAGCCAGTTTACAAGCATG
TCTCAAGCTAGTGTGTTCCATTATGCTCACAGCAGTAAATGCCTACCTCTGTGTTTGACATCTGAAAGAATACATTGAAGCAGCTTGTTG
CATTTGTTTTTCTGGCTTAGTAATCTAATAGATTTCCTTAAGGGCAGGAGATAGACTCTGGCCCTTGTTTCTAGCCTCCTTCCTTGCAGT
GTTTACAACATAGCCAGTGTTTACAGCATAGCAGATGCTGCTGCTGATTAAGAGAATAGATGCAAACAAGGCATGCATTTGGCCAAAATA

>In-frame_ENST00000561249_ENST00000306730_TCGA-D3-A5GL-06A_FMN1_chr15_33149216_-_AVEN_chr15_34168196_length(amino acids)=1425AA_start in transcript=126_stop in transcript=4403
MEGTHCTLQLHKPITELCYISFCLPKGEVRGFSYKGTVTLDRSNKGFHNCYQVREESDIISLSQEPDEHPGDIFFKQTPTKDILTELYKL
TTERERLLTNLLSSDHILGITMGNQEGKLQELSVSLAPEDDCFQSAGDWQGELPVGPLNKRSTHGNKKPRRSSGRRESFGALPQKRTKRK
GRGGRESAPLMGKDKICSSHSLPLSRTRPNLWVLEEKGNLLPNGALACSLQRRESCPPDIPKTPDTDLGFGSFETAFKDTGLGREVLPPD
CSSTEAGGDGIRRPPSGLEHQQTGLSESHQDPEKHPEAEKDEMEKPAKRTCKQKPVSKVVAKVQDLSSQVQRVVKTHSKGKETIAIRPAA
HAEFVPKADLLTLPGAEAGAHGSRRQGKERQGDRSSQSPAGETASISSVSASAEGAVNKVPLKVIESEKLDEAPEGKRLGFPVHTSVPHT
RPETRNKRRAGLPLGGHKSLFLDLPHKVGPDSSQPRGDKKKPSPPAPAALGKVFNNSASQSSTHKQTSPVPSPLSPRLPSPQQHHRILRL
PALPGEREAALNDSPCRKSRVFSGCVSADTLEPPSSAKVTETKGASPAFLRAGQPRLVPGETLEKSLGPGKTTAEPQHQSPPEYQAAILH
LKREHKEEIENLQAQFELRAFHIRGEHAMITARLEETIENLKHELEHRWRGGCEERKDVCISTDDDCPPKTFRNVCVQTDRETFLKPCES
ESKTTRSNQLVPKKLNISSLSQLSPPNDHKDIHAALQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPP
PPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQN
ATPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKKKPLSETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLE
TLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVK
DILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQVKFEDLIK
DLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLN
VAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELD

--------------------------------------------------------------
>In-frame_ENST00000559047_ENST00000306730_TCGA-D3-A5GL-06A_FMN1_chr15_33149216_-_AVEN_chr15_34168196_length(transcript)=4958nt_BP=3928nt
ATGGAAGGCACTCATTGTACCCTCCAATTGCATAAGCCCATTACGGAACTCTGCTACATCAGCTTCTGTCTTCCAAAGGGGGAAGTCAGA
GGATTTTCATACAAGGGCACTGTAACTCTAGACAGATCCAATAAAGGTTTTCATAACTGCTACCAAGTCAGGGAGGAGTCAGACATCATC
AGCCTCAGCCAGGAGCCGGACGAACATCCAGGCGACATATTTTTCAAGCAGACTCCCACGAAAGACATTCTAACTGAGCTGTACAAACTC
ACAACAGAGAGGGAGAGACTGCTAACCAATCTCCTGAGCTCAGACCACATCCTGGGGATCACGATGGGGAACCAGGAGGGGAAGCTGCAA
GAGCTGTCCGTGAGCCTGGCCCCCGAGGATGACTGTTTCCAGAGTGCTGGTGACTGGCAGGGAGAGCTCCCCGTGGGCCCTCTCAATAAG
AGGAGCACCCACGGGAACAAAAAGCCTCGGAGGTCTAGTGGAAGGAGAGAGAGCTTTGGGGCCCTTCCACAGAAGAGGACCAAAAGAAAA
GGGCGTGGAGGCCGAGAATCAGCTCCTCTGATGGGCAAGGACAAGATCTGTTCCAGCCACTCCCTTCCTCTTTCTAGAACAAGGCCTAAC
CTTTGGGTACTAGAGGAGAAAGGAAATCTGCTCCCGAATGGGGCACTTGCCTGCTCCCTGCAGAGGAGAGAGAGCTGCCCCCCAGATATT
CCCAAGACGCCAGACACAGACCTTGGCTTTGGGAGCTTTGAGACGGCTTTCAAGGACACTGGGCTTGGAAGAGAAGTGCTGCCCCCTGAC
TGCAGCTCCACAGAGGCAGGAGGGGATGGCATTCGGAGGCCGCCGAGCGGGCTGGAGCATCAGCAAACAGGTTTGTCTGAAAGTCACCAG
GACCCTGAGAAGCATCCAGAGGCAGAAAAGGATGAGATGGAGAAGCCGGCTAAGCGGACTTGCAAGCAGAAACCTGTCTCCAAAGTGGTG
GCCAAAGTTCAGGACCTGTCCTCCCAGGTACAAAGAGTAGTTAAAACGCATTCTAAGGGTAAGGAGACGATTGCCATTCGCCCAGCAGCC
CACGCTGAGTTTGTACCCAAAGCCGACTTGCTCACCCTCCCGGGAGCTGAGGCTGGGGCTCATGGCTCCAGGCGGCAGGGCAAGGAGCGG
CAAGGGGATAGGTCATCGCAGTCGCCAGCCGGGGAAACAGCCTCCATTTCTAGTGTGTCGGCCAGTGCCGAGGGGGCCGTGAACAAGGTC
CCCCTGAAGGTGATAGAGAGTGAGAAGTTAGATGAAGCCCCTGAGGGGAAAAGACTGGGCTTCCCTGTCCACACGAGTGTCCCTCACACT
CGCCCAGAAACGAGAAACAAGAGGAGAGCCGGGTTGCCCCTTGGTGGCCACAAGTCCTTGTTTCTGGATCTGCCCCACAAAGTAGGTCCT
GACTCCTCACAACCCAGAGGTGATAAGAAGAAGCCATCCCCACCAGCACCGGCAGCTCTTGGCAAGGTGTTTAATAATTCAGCCTCGCAG
TCCAGCACACACAAACAGACGTCACCTGTTCCCTCGCCTCTGTCTCCAAGGCTCCCCAGCCCTCAGCAGCATCACAGGATCCTCCGGCTC
CCTGCATTGCCTGGTGAGAGGGAAGCTGCTCTTAATGACTCTCCTTGTAGAAAGAGCCGTGTCTTCTCTGGGTGCGTCTCTGCTGACACC
TTGGAGCCACCATCCTCTGCAAAGGTCACGGAGACCAAAGGAGCCAGCCCGGCCTTCCTCAGAGCAGGCCAACCTCGGTTGGTGCCTGGG
GAAACTTTGGAAAAGAGCTTGGGGCCAGGGAAGACCACAGCTGAGCCCCAGCACCAGTCACCTCCAGGTATCTCCTCTGAGGGCTTTCCC
TGGGACGGCTTCAATGAGCAGACACCTAAAGACCTTCCCAACAGAGATGGAGGCGCGTGGGTTCTGGGCTACAGAGCGGGACCAGCCTGT
CCATTTTTGCTTCATGAGGAAAGGGAGAAGTCAAACAGGAGCGAATTGTACTTGGATCTCCATCCTGACCACAGCCTGACTGAGCAGGAT
GACAGGACTCCTGGCAGACTTCAAGCTGTCTGGCCACCCCCAAAGACAAAAGACACAGAAGAAAAAGTGGGACTGAAGTACACTGAAGCA
GAATACCAAGCTGCTATTTTACACTTGAAGAGGGAGCACAAAGAAGAAATTGAAAACCTGCAGGCACAGTTTGAACTTCGGGCATTTCAT
ATCCGGGGCGAGCATGCAATGATAACAGCGAGACTAGAAGAAACCATTGAAAATCTGAAACACGAGCTAGAACACAGATGGCGAGGGGGT
TGTGAAGAGAGGAAAGATGTGTGCATTTCCACCGATGATGACTGCCCTCCAAAGACCTTCAGAAATGTGTGCGTCCAGACAGACAGAGAG
ACCTTCCTCAAGCCCTGTGAAAGTGAAAGCAAGACAACCAGAAGTAATCAATTAGTACCCAAAAAGCTGAATATCTCCTCTTTAAGCCAG
CTCTCACCCCCAAATGACCACAAAGACATCCATGCAGCACTCCAGCCAATGGAGGGCATGGCATCAAATCAGCAGAAGGCATTGCCTCCG
CCTCCCGCATCCATCCCTCCCCCTCCGCCCCTCCCCTCAGGACTTGGATCTTTGTCTCCCGCACCTCCAATGCCACCTGTGAGTGCTGGG
CCACCGCTACCACCTCCGCCTCCTCCACCGCCACCTCTACCTCCACCTTCAAGTGCTGGACCTCCACCACCCCCACCCCCACCCCCACTT
CCTAACTCCCCTGCCCCACCCAACCCTGGAGGGCCTCCTCCTGCTCCACCACCCCCAGGACTTGCACCCCCACCTCCCCCTGGACTCTTC
TTTGGACTTGGCTCTTCTTCCAGTCAATGTCCTCGAAAACCAGCCATCGAGCCCAGTTGTCCCATGAAGCCTTTATATTGGACTAGGATA
CAAATAAGTGATAGGAGCCAAAATGCTACACCAACCTTATGGGACTCCTTAGAAGAACCTGACATTCGGGACCCCAGTGAATTTGAGTAT
TTATTCTCCAAAGACACAACTCAACAGAAGAAAAAACCTCTGTCAGAGACTTATGAGAAGAAAAACAAGGTCAAAAAGATCATCAAATTG
TTGGATGGAAAACGATCTCAAACTGTGGGAATCTTGATATCTAGTTTACATTTAGAAATGAAGGATATCCAACAGGCCATTTTCAATGTG
GATGACTCCGTGGTTGATCTGGAGACCCTGGCAGCCTTATATGAAAACAGAGCCCAAGAGGATGAGCTGGTTAAAATAAGAAAGTATTAC
GAGACATCCAAAGAAGAAGAACTGAAGCTGCTGGATAAACCTGAGCAATTTTTACATGAGTTAGCCCAGATTCCTAATTTTGCTGAACGT
GCCCAGTGCATAATCTTCAGATCTGTCTTTTCTGAGGGTATCACCTCCTTGCACAGAAAGGTAGAGATCATCACGCGAGCTTCTAAGGAC
TTGCTGCACGTGAAGAGCGTGAAGGATATTTTAGCTCTCATCTTGGCTTTTGGAAATTATATGAATGGAGGAAATAGGACTCGGGGACAA
GCCGATGGATATAGCTTAGAAATTCTGCCCAAACTCAAGGATGTCAAAAGTCGGGATAATGGGATTAATCTGGTGGACTACGTTGTTAAG
TATTACCTGCGTTACTATGATCAGGAAGCTGGAACAGAAAAGAGTGTTTTCCCCTTGCCGGAACCACAGGATTTCTTTCTGGCCTCCCAA
GTCAAGTTTGAAGACCTCATAAAAGATTTGAGAAAACTGAAGAGGCAACTAGAAGCAAGTGAGAAACAGATGGTGGTGGTGTGCAAGGAG
TCCCCAAAGGAGTATCTCCAGCCTTTCAAGGACAAACTAGAGGAGTTCTTCCAAAAAGGGGACTCATTCTCACAGTTCCGGTTTGCTGAG
GAGAAAGAATGGGATAGTGAAGCTTCTTGTCCAAAACAGAATTCAGCATTTTATGTGGATAGTGAGTTATTGGTTCGAGCCCTTCAAGAG
CTGCCTCTCTGCCTCCGACTCAACGTTGCTGCCGAACTGGTCCAGGGTACAGTTCCTTTAGAGGTTCCTCAGGTGAAACCAAAGAGAACT
GATGATGGCAAGGGATTAGGGATGCAGTTAAAGGGGCCCTTGGGGCCTGGAGGAAGGGGGCCCATCTTTGAGCTGAAATCTGTGGCTGCT
GGCTGCCCTGTGTTGCTGGGCAAAGACAACCCAAGCCCGGGTCCTTCAAGGGATTCTCAGAAACCCACTTCCCCACTGCAGTCAGCAGGA
GACCATTTGGAAGAAGAACTAGATCTGTTGCTTAATTTAGATGCACCTATAAAAGAGGGAGATAACATCTTACCAGATCAGACGTCTCAG
GACCTGAAATCCAAGGAAGATGGGGAGGTGGTCCAAGAGGAAGAAGTTTGTGCAAAACCATCTGTGACTGAAGAAAAAAACATGGAACCT
GAGCAACCAAGTACCTCCAAAAATGTTACCGAGGAAGAGCTGGAAGACTGGTTGGACAGCATGATTTCCTAAAAAGGGGAAAAAAAGTGC
CTGAAGCAAATCTTGGTTGCCTTCTAACGGCAGGTGGGCATAAGGCTGTCCTTCAGGACCAGCCAGTTTACAAGCATGTCTCAAGCTAGT
GTGTTCCATTATGCTCACAGCAGTAAATGCCTACCTCTGTGTTTGACATCTGAAAGAATACATTGAAGCAGCTTGTTGCATTTGTTTTTC
TGGCTTAGTAATCTAATAGATTTCCTTAAGGGCAGGAGATAGACTCTGGCCCTTGTTTCTAGCCTCCTTCCTTGCAGTGTTTACAACATA
GCCAGTGTTTACAGCATAGCAGATGCTGCTGCTGATTAAGAGAATAGATGCAAACAAGGCATGCATTTGGCCAAAATAAACAAATGCTGG

>In-frame_ENST00000559047_ENST00000306730_TCGA-D3-A5GL-06A_FMN1_chr15_33149216_-_AVEN_chr15_34168196_length(amino acids)=1523AA_start in transcript=0_stop in transcript=4571
MEGTHCTLQLHKPITELCYISFCLPKGEVRGFSYKGTVTLDRSNKGFHNCYQVREESDIISLSQEPDEHPGDIFFKQTPTKDILTELYKL
TTERERLLTNLLSSDHILGITMGNQEGKLQELSVSLAPEDDCFQSAGDWQGELPVGPLNKRSTHGNKKPRRSSGRRESFGALPQKRTKRK
GRGGRESAPLMGKDKICSSHSLPLSRTRPNLWVLEEKGNLLPNGALACSLQRRESCPPDIPKTPDTDLGFGSFETAFKDTGLGREVLPPD
CSSTEAGGDGIRRPPSGLEHQQTGLSESHQDPEKHPEAEKDEMEKPAKRTCKQKPVSKVVAKVQDLSSQVQRVVKTHSKGKETIAIRPAA
HAEFVPKADLLTLPGAEAGAHGSRRQGKERQGDRSSQSPAGETASISSVSASAEGAVNKVPLKVIESEKLDEAPEGKRLGFPVHTSVPHT
RPETRNKRRAGLPLGGHKSLFLDLPHKVGPDSSQPRGDKKKPSPPAPAALGKVFNNSASQSSTHKQTSPVPSPLSPRLPSPQQHHRILRL
PALPGEREAALNDSPCRKSRVFSGCVSADTLEPPSSAKVTETKGASPAFLRAGQPRLVPGETLEKSLGPGKTTAEPQHQSPPGISSEGFP
WDGFNEQTPKDLPNRDGGAWVLGYRAGPACPFLLHEEREKSNRSELYLDLHPDHSLTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEA
EYQAAILHLKREHKEEIENLQAQFELRAFHIRGEHAMITARLEETIENLKHELEHRWRGGCEERKDVCISTDDDCPPKTFRNVCVQTDRE
TFLKPCESESKTTRSNQLVPKKLNISSLSQLSPPNDHKDIHAALQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAG
PPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRI
QISDRSQNATPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKKKPLSETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNV
DDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKD
LLHVKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQ
VKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQE
LPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FMN1-AVEN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FMN1-AVEN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FMN1-AVEN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAVENC0007131Non-Small Cell Lung Carcinoma1CTD_human