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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FNDC3B-CYB5A (FusionGDB2 ID:30813)

Fusion Gene Summary for FNDC3B-CYB5A

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3B-CYB5A
Fusion gene ID: 30813
HgeneTgene
Gene symbol

FNDC3B

CYB5A

Gene ID

64778

1528

Gene namefibronectin type III domain containing 3Bcytochrome b5 type A
SynonymsFAD104|PRO4979|YVTM2421CYB5|MCB5|METAG
Cytomap

3q26.31

18q22.3

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104cytochrome b5cytochrome b5 type A (microsomal)epididymis secretory sperm binding proteintype 1 cyt-b5
Modification date2020031320200313
UniProtAcc

Q53EP0

P00167

Ensembl transtripts involved in fusion geneENST00000415807, ENST00000336824, 
ENST00000416957, ENST00000392699, 
ENST00000421757, ENST00000423424, 
ENST00000476794, 		ENST00000340533, 
ENST00000494131, ENST00000397914, 
ENST00000299438, ENST00000579064, 
Fusion gene scores* DoF score30 X 18 X 19=1026012 X 9 X 7=756
# samples 3913
** MAII scorelog2(39/10260*10)=-4.71741279674481
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/756*10)=-2.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FNDC3B [Title/Abstract] AND CYB5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFNDC3B(171944737)-CYB5A(71923010), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FNDC3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CYB5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2102FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-


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Fusion Gene ORF analysis for FNDC3B-CYB5A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000415807ENST00000340533FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-3UTRENST00000415807ENST00000494131FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-3UTRENST00000415807ENST00000397914FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-3UTRENST00000415807ENST00000299438FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-5UTRENST00000415807ENST00000579064FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
In-frameENST00000336824ENST00000340533FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-3UTRENST00000336824ENST00000494131FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-3UTRENST00000336824ENST00000397914FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-3UTRENST00000336824ENST00000299438FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-5UTRENST00000336824ENST00000579064FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
In-frameENST00000416957ENST00000340533FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-3UTRENST00000416957ENST00000494131FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-3UTRENST00000416957ENST00000397914FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-3UTRENST00000416957ENST00000299438FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
5CDS-5UTRENST00000416957ENST00000579064FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3CDSENST00000392699ENST00000340533FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000392699ENST00000494131FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000392699ENST00000397914FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000392699ENST00000299438FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-5UTRENST00000392699ENST00000579064FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3CDSENST00000421757ENST00000340533FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000421757ENST00000494131FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000421757ENST00000397914FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000421757ENST00000299438FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-5UTRENST00000421757ENST00000579064FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3CDSENST00000423424ENST00000340533FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000423424ENST00000494131FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000423424ENST00000397914FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000423424ENST00000299438FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-5UTRENST00000423424ENST00000579064FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3CDSENST00000476794ENST00000340533FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000476794ENST00000494131FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000476794ENST00000397914FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-3UTRENST00000476794ENST00000299438FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-
intron-5UTRENST00000476794ENST00000579064FNDC3Bchr3

171944737

+CYB5Achr18

71923010

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415807FNDC3Bchr3171944737+ENST00000340533CYB5Achr1871923010-841436172552126
ENST00000336824FNDC3Bchr3171944737+ENST00000340533CYB5Achr1871923010-76836399479126
ENST00000416957FNDC3Bchr3171944737+ENST00000340533CYB5Achr1871923010-73232763443126

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415807ENST00000340533FNDC3Bchr3171944737+CYB5Achr1871923010-0.0043969620.9956031
ENST00000336824ENST00000340533FNDC3Bchr3171944737+CYB5Achr1871923010-0.0028742740.9971257
ENST00000416957ENST00000340533FNDC3Bchr3171944737+CYB5Achr1871923010-0.0031502980.9968497

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Fusion Genomic Features for FNDC3B-CYB5A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FNDC3B-CYB5A


check button Go to

FGviewer for the breakpoints of chr3:171944737-chr18:71923010

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3B

Q53EP0

CYB5A

P00167

FUNCTION: May be a positive regulator of adipogenesis. {ECO:0000269|PubMed:15564382}.FUNCTION: Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCYB5Achr3:171944737chr18:71923010ENST0000034053325109_13196.0135.0TransmembraneHelical
TgeneCYB5Achr3:171944737chr18:71923010ENST0000039791414109_13186.0125.0TransmembraneHelical
TgeneCYB5Achr3:171944737chr18:71923010ENST0000049413136109_131104.0125.66666666666667TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+426231_24388.01205.0Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+426231_24388.01205.0Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+426231_24388.01205.0Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+14231_243072.0Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+14231_243072.0Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+4261056_115388.01205.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+426278_37788.01205.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+426381_47388.01205.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+426477_57088.01205.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+426574_66988.01205.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+426673_76588.01205.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+426766_85988.01205.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+426871_95788.01205.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+426958_105288.01205.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+4261056_115388.01205.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+426278_37788.01205.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+426381_47388.01205.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+426477_57088.01205.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+426574_66988.01205.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+426673_76588.01205.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+426766_85988.01205.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+426871_95788.01205.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+426958_105288.01205.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+4261056_115388.01205.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+426278_37788.01205.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+426381_47388.01205.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+426477_57088.01205.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+426574_66988.01205.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+426673_76588.01205.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+426766_85988.01205.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+426871_95788.01205.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+426958_105288.01205.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+141056_1153072.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+14278_377072.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+14381_473072.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+14477_570072.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+14574_669072.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+14673_765072.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+14766_859072.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+14871_957072.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+14958_1052072.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+141056_1153072.0DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+14278_377072.0DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+14381_473072.0DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+14477_570072.0DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+14574_669072.0DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+14673_765072.0DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+14766_859072.0DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+14871_957072.0DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+14958_1052072.0DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000336824+4261182_120288.01205.0TransmembraneHelical
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000415807+4261182_120288.01205.0TransmembraneHelical
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000416957+4261182_120288.01205.0TransmembraneHelical
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000421757+141182_1202072.0TransmembraneHelical
HgeneFNDC3Bchr3:171944737chr18:71923010ENST00000423424+141182_1202072.0TransmembraneHelical
TgeneCYB5Achr3:171944737chr18:71923010ENST00000340533259_8596.0135.0DomainCytochrome b5 heme-binding
TgeneCYB5Achr3:171944737chr18:71923010ENST00000397914149_8586.0125.0DomainCytochrome b5 heme-binding
TgeneCYB5Achr3:171944737chr18:71923010ENST00000494131369_85104.0125.66666666666667DomainCytochrome b5 heme-binding


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Fusion Gene Sequence for FNDC3B-CYB5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000415807_ENST00000340533_TCGA-61-2102_FNDC3B_chr3_171944737_+_CYB5A_chr18_71923010_length(transcript)=841nt_BP=436nt
GCGGCGGCGGCGGCTGGAGGAGGAGAGCGGCGGCGGCGGGAGCAGCGAAGGGGGCGGCAGGGATCCTCCAGGCTGCCGGCTGGGAAGGCG
TGGGCGACCCGGTGTGTGGCGCGCCCAGAGCCCCGCGTTTCAGCCCTAGGGAAGGAAGCCAGTTGAGGGAAGTTCTCCATGAATGTACGT
CACAATGATGATGACCGACCAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCCCACTTGGTGAATGGAGA
TGCAGCTCAGCAGGTTATTCTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACACTTCAGTGCATTCAAGG
ACCTGCTGAAGTTCCCATGATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCACAGGAAACTCTTATCAC
TACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACAT
GGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAAC
TGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAAAGAACTGTCCTT
TCTGCGCTCAAATTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTATTATAAGCATGA

>In-frame_ENST00000415807_ENST00000340533_TCGA-61-2102_FNDC3B_chr3_171944737_+_CYB5A_chr18_71923010_length(amino acids)=126AA_start in transcript=172_stop in transcript=552
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQET

--------------------------------------------------------------
>In-frame_ENST00000336824_ENST00000340533_TCGA-61-2102_FNDC3B_chr3_171944737_+_CYB5A_chr18_71923010_length(transcript)=768nt_BP=363nt
AAGCTCGGGCGGGGGAGCGGGGCGCGGCGGGAAGGAGCGGGCGACCCGGTGTGTGGGCCAGCGGAGCTCCGGAAGCCAGTTGAGGGAAGT
TCTCCATGAATGTACGTCACAATGATGATGACCGACCAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCC
CACTTGGTGAATGGAGATGCAGCTCAGCAGGTTATTCTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACA
CTTCAGTGCATTCAAGGACCTGCTGAAGTTCCCATGATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCA
CAGGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTG
ATGTATCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCA
TTGCTAACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAA
CAAAAAGAACTGTCCTTTCTGCGCTCAAATTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTT

>In-frame_ENST00000336824_ENST00000340533_TCGA-61-2102_FNDC3B_chr3_171944737_+_CYB5A_chr18_71923010_length(amino acids)=126AA_start in transcript=99_stop in transcript=479
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQET

--------------------------------------------------------------
>In-frame_ENST00000416957_ENST00000340533_TCGA-61-2102_FNDC3B_chr3_171944737_+_CYB5A_chr18_71923010_length(transcript)=732nt_BP=327nt
AGTGTCTACCACCAAACTCCTAAGGCTGGATGGTGGAAGCCAGTTGAGGGAAGTTCTCCATGAATGTACGTCACAATGATGATGACCGAC
CAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCCCACTTGGTGAATGGAGATGCAGCTCAGCAGGTTATT
CTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACACTTCAGTGCATTCAAGGACCTGCTGAAGTTCCCATG
ATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCACAGGAAACTCTTATCACTACTATTGATTCTAGTTCC
AGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTGAACACCT
CCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCTTCACTTG
AAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAAAGAACTGTCCTTTCTGCGCTCAAATTTTTCG
AGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTATTATAAGCATGATCTTTTAAAAATATATTTG

>In-frame_ENST00000416957_ENST00000340533_TCGA-61-2102_FNDC3B_chr3_171944737_+_CYB5A_chr18_71923010_length(amino acids)=126AA_start in transcript=63_stop in transcript=443
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQET

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Fusion Gene PPI Analysis for FNDC3B-CYB5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FNDC3B-CYB5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCYB5AP00167DB11136ChromiumSubstrateSmall moleculeApproved
TgeneCYB5AP00167DB11136ChromiumSubstrateSmall moleculeApproved
TgeneCYB5AP00167DB14527Chromic nitrateSmall moleculeApproved
TgeneCYB5AP00167DB14527Chromic nitrateSmall moleculeApproved
TgeneCYB5AP00167DB14528Chromium gluconateSmall moleculeApproved
TgeneCYB5AP00167DB14528Chromium gluconateSmall moleculeApproved
TgeneCYB5AP00167DB14530Chromous sulfateSmall moleculeApproved
TgeneCYB5AP00167DB14530Chromous sulfateSmall moleculeApproved
TgeneCYB5AP00167DB14529Chromium nicotinateSmall moleculeApproved|Experimental
TgeneCYB5AP00167DB14529Chromium nicotinateSmall moleculeApproved|Experimental

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Related Diseases for FNDC3B-CYB5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFNDC3BC0017612Glaucoma, Open-Angle1CTD_human
HgeneFNDC3BC0022578Keratoconus1CTD_human
HgeneFNDC3BC0023487Acute Promyelocytic Leukemia1CTD_human
HgeneFNDC3BC0271148Secondary Open Angle Glaucoma1CTD_human
HgeneFNDC3BC0339573Glaucoma, Primary Open Angle1CTD_human
TgeneCYB5AC4285231METHEMOGLOBINEMIA AND AMBIGUOUS GENITALIA3GENOMICS_ENGLAND;UNIPROT
TgeneCYB5AC0014175Endometriosis1CTD_human
TgeneCYB5AC0028754Obesity1CTD_human
TgeneCYB5AC0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneCYB5AC0268285Adrenal hyperplasia, congenital, type 51ORPHANET
TgeneCYB5AC0269102Endometrioma1CTD_human