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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FOSL2-P4HB (FusionGDB2 ID:30935)

Fusion Gene Summary for FOSL2-P4HB

check button Fusion gene summary
Fusion gene informationFusion gene name: FOSL2-P4HB
Fusion gene ID: 30935
HgeneTgene
Gene symbol

FOSL2

P4HB

Gene ID

2355

5034

Gene nameFOS like 2, AP-1 transcription factor subunitprolyl 4-hydroxylase subunit beta
SynonymsFRA2CLCRP1|DSI|ERBA2L|GIT|P4Hbeta|PDI|PDIA1|PHDB|PO4DB|PO4HB|PROHB
Cytomap

2p23.2

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionfos-related antigen 2FOS like 2, AP-1 trancription factor subunitFOS like antigen 2FRA-2protein disulfide-isomerasecellular thyroid hormone-binding proteincollagen prolyl 4-hydroxylase betaglutathione-insulin transhydrogenasep55procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideprolyl 4-hydroxyla
Modification date2020031320200329
UniProtAcc

P15408

.
Ensembl transtripts involved in fusion geneENST00000460736, ENST00000379619, 
ENST00000264716, ENST00000545753, 
ENST00000331483, ENST00000576390, 
ENST00000439918, ENST00000472244, 
Fusion gene scores* DoF score6 X 7 X 5=21018 X 16 X 10=2880
# samples 921
** MAII scorelog2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2880*10)=-3.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOSL2 [Title/Abstract] AND P4HB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOSL2(28631733)-P4HB(79801968), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOSL2

GO:0045944

positive regulation of transcription by RNA polymerase II

13679379

TgeneP4HB

GO:0018401

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

7753822


check buttonFusion gene breakpoints across FOSL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across P4HB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer265NFOSL2chr2

28631733

+P4HBchr17

79801968

-


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Fusion Gene ORF analysis for FOSL2-P4HB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000460736ENST00000331483FOSL2chr2

28631733

+P4HBchr17

79801968

-
intron-intronENST00000460736ENST00000576390FOSL2chr2

28631733

+P4HBchr17

79801968

-
intron-intronENST00000460736ENST00000439918FOSL2chr2

28631733

+P4HBchr17

79801968

-
intron-intronENST00000460736ENST00000472244FOSL2chr2

28631733

+P4HBchr17

79801968

-
In-frameENST00000379619ENST00000331483FOSL2chr2

28631733

+P4HBchr17

79801968

-
5CDS-intronENST00000379619ENST00000576390FOSL2chr2

28631733

+P4HBchr17

79801968

-
5CDS-intronENST00000379619ENST00000439918FOSL2chr2

28631733

+P4HBchr17

79801968

-
5CDS-intronENST00000379619ENST00000472244FOSL2chr2

28631733

+P4HBchr17

79801968

-
In-frameENST00000264716ENST00000331483FOSL2chr2

28631733

+P4HBchr17

79801968

-
5CDS-intronENST00000264716ENST00000576390FOSL2chr2

28631733

+P4HBchr17

79801968

-
5CDS-intronENST00000264716ENST00000439918FOSL2chr2

28631733

+P4HBchr17

79801968

-
5CDS-intronENST00000264716ENST00000472244FOSL2chr2

28631733

+P4HBchr17

79801968

-
In-frameENST00000545753ENST00000331483FOSL2chr2

28631733

+P4HBchr17

79801968

-
5CDS-intronENST00000545753ENST00000576390FOSL2chr2

28631733

+P4HBchr17

79801968

-
5CDS-intronENST00000545753ENST00000439918FOSL2chr2

28631733

+P4HBchr17

79801968

-
5CDS-intronENST00000545753ENST00000472244FOSL2chr2

28631733

+P4HBchr17

79801968

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379619FOSL2chr228631733+ENST00000331483P4HBchr1779801968-132939553559158
ENST00000264716FOSL2chr228631733+ENST00000331483P4HBchr1779801968-225913257041405233
ENST00000545753FOSL2chr228631733+ENST00000331483P4HBchr1779801968-135942556589158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379619ENST00000331483FOSL2chr228631733+P4HBchr1779801968-0.0203987840.9796012
ENST00000264716ENST00000331483FOSL2chr228631733+P4HBchr1779801968-0.0123505470.9876495
ENST00000545753ENST00000331483FOSL2chr228631733+P4HBchr1779801968-0.0280698760.9719301

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Fusion Genomic Features for FOSL2-P4HB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FOSL2-P4HB


check button Go to

FGviewer for the breakpoints of chr2:28631733-chr17:79801968

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOSL2

P15408

.
FUNCTION: Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOSL2chr2:28631733chr17:79801968ENST00000264716+34126_128154.0327.0RegionBasic motif
HgeneFOSL2chr2:28631733chr17:79801968ENST00000264716+34129_136154.0327.0RegionLeucine-zipper
HgeneFOSL2chr2:28631733chr17:79801968ENST00000379619+34126_128129.0319.0RegionBasic motif
TgeneP4HBchr2:28631733chr17:79801968ENST00000331483911505_508482.0509.0MotifNote=Prevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOSL2chr2:28631733chr17:79801968ENST00000264716+34124_187154.0327.0DomainbZIP
HgeneFOSL2chr2:28631733chr17:79801968ENST00000379619+34124_187129.0319.0DomainbZIP
HgeneFOSL2chr2:28631733chr17:79801968ENST00000545753+34124_187115.0288.0DomainbZIP
HgeneFOSL2chr2:28631733chr17:79801968ENST00000379619+34129_136129.0319.0RegionLeucine-zipper
HgeneFOSL2chr2:28631733chr17:79801968ENST00000545753+34126_128115.0288.0RegionBasic motif
HgeneFOSL2chr2:28631733chr17:79801968ENST00000545753+34129_136115.0288.0RegionLeucine-zipper
TgeneP4HBchr2:28631733chr17:79801968ENST0000033148391118_134482.0509.0DomainThioredoxin 1
TgeneP4HBchr2:28631733chr17:79801968ENST00000331483911349_475482.0509.0DomainThioredoxin 2


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Fusion Gene Sequence for FOSL2-P4HB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000379619_ENST00000331483_265N_FOSL2_chr2_28631733_+_P4HB_chr17_79801968_length(transcript)=1329nt_BP=395nt
GAATCCACATGGTACAGGGCTGGAGAATAAAGAGTAAATTCCGGGTAGATATGCCTGGCTCAGGCAGTGCATTCATCCCCACCATCAACG
CCATCACGACCAGCCAGGACCTGCAGTGGATGGTGCAGCCCACAGTGATCACCTCCATGTCCAACCCATACCCTCGCTCGCACCCCTACA
GCCCCCTGCCGGGCCTGGCCTCTGTCCCTGGACACATGGCCCTCCCAAGACCTGGCGTGATCAAGACCATTGGCACCACCGTGGGCCGCA
GGAGGAGAGATGAGCAGCTGTCTCCTGAAGAGGAGGAGAAGCGTCGCATCCGGCGGGAGAGGAACAAGCTGGCTGCAGCCAAGTGCCGGA
ACCGACGCCGGGAGCTGACAGAGAAGCTGCAGGCGGATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGAGGAAGACGATGATC
AGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGGGCTGCACACCCAGCAGCAGCGCA
CGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGACACCTCACCCCTACACACCG
TCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCCACCCTGGTGGGGCTTGTTTCCTG
AAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCCTCCCTCCCGCGGGAGGTTT
CTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCACCTTGGCCAGGCCTCCTCGGAGA
AGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGTCGCCATGACTGATCATGGCTCTT
GCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTGGTGGCTGCCAGCCCTGGGGCCCG
GCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACTGGCCTCTCTACAGCACGGC
CTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGGAGCTGAATCAGACGCTGACAGTT

>In-frame_ENST00000379619_ENST00000331483_265N_FOSL2_chr2_28631733_+_P4HB_chr17_79801968_length(amino acids)=158AA_start in transcript=535_stop in transcript=59
MLLGVQPPRGLGSARVWLCVLQFIFHSFLIIVFLHVWLLCFFQVLEIRLQLLCQLPASVPALGCSQLVPLPPDATLLLLFRRQLLISPPA

--------------------------------------------------------------
>In-frame_ENST00000264716_ENST00000331483_265N_FOSL2_chr2_28631733_+_P4HB_chr17_79801968_length(transcript)=2259nt_BP=1325nt
GTAGTGACTCATCTCGGGCAGAGCGCTAGGGCTCCGAGCGAACCAGCGAGCGAGCGAACGAGCGGCGCTCGGCGGGGACAGAAAGAGGGA
GAGAGAGAGAGAGAGAGAGGGAGAGGCGCGGCCGGGCGAGGCGGGCCCGTCCGGGAGCGGGCTCCGGGGAAGGGGTGCGGGTCTGGGCGC
CGGAGCGGGGAGCGGGGCCGCGTCCCTCTCAGCGCCAGCTCTACTTGAGCCCCACGAGCCGCTGTCCCCCTGGCGCGCTCGGGGCCGCGG
GACGGGCGCACGCCGCCTTCTCCTAGTCAAGTATCCGAGCCGCCCCGAAACTCGGGCGGCGAGTCGGCCACGGGAAGTTTATTCTCCGGC
TCCTTTTCTAAAAGGAAGAAACAGAAGTTTCTCCCAGCGGACAGCTTTTCTTTCCGCCTTTTTGGCCCTGTCTGAAATCGGGGGTCCCCA
GGGCTGGCAGGCCAGGCTCGCTGGGCTCCTAATCTTTTTTTTAATTTCCAATTTTTGATTGGGCCGTGGGTCCCCGCTGAGCTCCGGCTG
CGCGCGGGGGCGGGAGGGCGCGCGCAGGGGAGGGACCGAGAGACGCGCCGACTTTTTAGAGGGAGGGATCGGGTGGACAACTGGTCCCGC
GGCGCTCGCAGAGCCGGAAAGAAGTGCTGTAAGGGACGCTCGGGGGACGCTGTTCCTGAGGTGTCGCCGCCTCCCTGTCCTCGCCCTCCG
CGGTGGGGGAGAAACCCAGGAGCGAAGCCCAGAGCCCGCGGCGCGGCCGGCGGACGAACGAGCGCGCAGCAGCCGGTGCGCGGCCGCGGC
GAGGGCGGGGGAAGAAAAACACCCTGTTTCCTCTCCGGCCCCCACCGCGGATCATGTACCAGGATTATCCCGGGAACTTTGACACCTCGT
CCCGGGGCAGCAGCGGCTCTCCTGCGCACGCCGAGTCCTACTCCAGCGGCGGCGGCGGCCAGCAGAAATTCCGGGTAGATATGCCTGGCT
CAGGCAGTGCATTCATCCCCACCATCAACGCCATCACGACCAGCCAGGACCTGCAGTGGATGGTGCAGCCCACAGTGATCACCTCCATGT
CCAACCCATACCCTCGCTCGCACCCCTACAGCCCCCTGCCGGGCCTGGCCTCTGTCCCTGGACACATGGCCCTCCCAAGACCTGGCGTGA
TCAAGACCATTGGCACCACCGTGGGCCGCAGGAGGAGAGATGAGCAGCTGTCTCCTGAAGAGGAGGAGAAGCGTCGCATCCGGCGGGAGA
GGAACAAGCTGGCTGCAGCCAAGTGCCGGAACCGACGCCGGGAGCTGACAGAGAAGCTGCAGGCGGATCTCGAGGACCTGGAAGAAGCAG
AGGAGCCAGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCC
CTCGGGGGCTGCACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTC
TCTGAAGTGACACCTCACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAG
GCAGCCCACCCTGGTGGGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGA
GTCTCGCTGCCTCCCTCCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATT
TGTTCCACCTTGGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCT
GCAGTGTCGCCATGACTGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGA
GGAGCTGGTGGCTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCA
TTGTGACCACTGGCCTCTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGG
ATGCTGGAGCTGAATCAGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTT

>In-frame_ENST00000264716_ENST00000331483_265N_FOSL2_chr2_28631733_+_P4HB_chr17_79801968_length(amino acids)=233AA_start in transcript=704_stop in transcript=1405
MSSPSAVGEKPRSEAQSPRRGRRTNERAAAGARPRRGRGKKNTLFPLRPPPRIMYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFR
VDMPGSGSAFIPTINAITTSQDLQWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGVIKTIGTTVGRRRRDEQLSPEEEEKR

--------------------------------------------------------------
>In-frame_ENST00000545753_ENST00000331483_265N_FOSL2_chr2_28631733_+_P4HB_chr17_79801968_length(transcript)=1359nt_BP=425nt
ATAGACGCCTGCCCATTCGGCCCGGCAGTGTGTGAGGCGCCTTTCAAACCGGAGGGATTGGCAAGAAATTCCGGGTAGATATGCCTGGCT
CAGGCAGTGCATTCATCCCCACCATCAACGCCATCACGACCAGCCAGGACCTGCAGTGGATGGTGCAGCCCACAGTGATCACCTCCATGT
CCAACCCATACCCTCGCTCGCACCCCTACAGCCCCCTGCCGGGCCTGGCCTCTGTCCCTGGACACATGGCCCTCCCAAGACCTGGCGTGA
TCAAGACCATTGGCACCACCGTGGGCCGCAGGAGGAGAGATGAGCAGCTGTCTCCTGAAGAGGAGGAGAAGCGTCGCATCCGGCGGGAGA
GGAACAAGCTGGCTGCAGCCAAGTGCCGGAACCGACGCCGGGAGCTGACAGAGAAGCTGCAGGCGGATCTCGAGGACCTGGAAGAAGCAG
AGGAGCCAGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCC
CTCGGGGGCTGCACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTC
TCTGAAGTGACACCTCACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAG
GCAGCCCACCCTGGTGGGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGA
GTCTCGCTGCCTCCCTCCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATT
TGTTCCACCTTGGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCT
GCAGTGTCGCCATGACTGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGA
GGAGCTGGTGGCTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCA
TTGTGACCACTGGCCTCTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGG
ATGCTGGAGCTGAATCAGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTT

>In-frame_ENST00000545753_ENST00000331483_265N_FOSL2_chr2_28631733_+_P4HB_chr17_79801968_length(amino acids)=158AA_start in transcript=565_stop in transcript=89
MLLGVQPPRGLGSARVWLCVLQFIFHSFLIIVFLHVWLLCFFQVLEIRLQLLCQLPASVPALGCSQLVPLPPDATLLLLFRRQLLISPPA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FOSL2-P4HB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOSL2-P4HB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FOSL2-P4HB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFOSL2C0017636Glioblastoma1CTD_human
HgeneFOSL2C0024121Lung Neoplasms1CTD_human
HgeneFOSL2C0087031Juvenile-Onset Still Disease1CTD_human
HgeneFOSL2C0242379Malignant neoplasm of lung1CTD_human
HgeneFOSL2C0334588Giant Cell Glioblastoma1CTD_human
HgeneFOSL2C1621958Glioblastoma Multiforme1CTD_human
HgeneFOSL2C3495559Juvenile arthritis1CTD_human
HgeneFOSL2C3714758Juvenile psoriatic arthritis1CTD_human
HgeneFOSL2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneFOSL2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneP4HBC4317154COLE-CARPENTER SYNDROME 12GENOMICS_ENGLAND;UNIPROT
TgeneP4HBC0001787Osteoporosis, Age-Related1CTD_human
TgeneP4HBC0019193Hepatitis, Toxic1CTD_human
TgeneP4HBC0029434Osteogenesis Imperfecta1GENOMICS_ENGLAND
TgeneP4HBC0029456Osteoporosis1CTD_human
TgeneP4HBC0029459Osteoporosis, Senile1CTD_human
TgeneP4HBC0033578Prostatic Neoplasms1CTD_human
TgeneP4HBC0151744Myocardial Ischemia1CTD_human
TgeneP4HBC0376358Malignant neoplasm of prostate1CTD_human
TgeneP4HBC0751406Post-Traumatic Osteoporosis1CTD_human
TgeneP4HBC0860207Drug-Induced Liver Disease1CTD_human
TgeneP4HBC1262760Hepatitis, Drug-Induced1CTD_human
TgeneP4HBC1846707SPINOCEREBELLAR ATAXIA 171CTD_human
TgeneP4HBC1862178Cole Carpenter syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneP4HBC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneP4HBC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneP4HBC4279912Chemically-Induced Liver Toxicity1CTD_human