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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FOSL2-SNX17 (FusionGDB2 ID:30937)

Fusion Gene Summary for FOSL2-SNX17

Fusion gene summary

Fusion gene information	Fusion gene name: FOSL2-SNX17
	Fusion gene ID: 30937
		Hgene	Tgene
	Gene symbol	FOSL2	SNX17
	Gene ID	2355	9784
	Gene name	FOS like 2, AP-1 transcription factor subunit	sorting nexin 17
	Synonyms	FRA2	-
	Cytomap	2p23.2	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	fos-related antigen 2FOS like 2, AP-1 trancription factor subunitFOS like antigen 2FRA-2	sorting nexin-17
	Modification date	20200313	20200313
	UniProtAcc	P15408	.
	Ensembl transtripts involved in fusion gene	ENST00000460736, ENST00000379619, ENST00000264716, ENST00000545753,	ENST00000233575, ENST00000543024, ENST00000537606, ENST00000542478,
Fusion gene scores	* DoF score	6 X 7 X 5=210	1 X 2 X 1=2
	# samples	9	2
	** MAII score	log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/2*10)=3.32192809488736
Context	PubMed: FOSL2 [Title/Abstract] AND SNX17 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FOSL2(28616689)-SNX17(27594136), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FOSL2	GO:0045944	positive regulation of transcription by RNA polymerase II	13679379

Fusion gene breakpoints across FOSL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SNX17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-61-1738-01A	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
ChimerDB4	OV	TCGA-61-1738	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
ChimerDB4	OV	TCGA-61-1738-01A	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+

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Fusion Gene ORF analysis for FOSL2-SNX17

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000460736	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-intron	ENST00000460736	ENST00000543024	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-intron	ENST00000460736	ENST00000537606	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-5UTR	ENST00000460736	ENST00000542478	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-3CDS	ENST00000379619	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-intron	ENST00000379619	ENST00000543024	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-intron	ENST00000379619	ENST00000537606	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-5UTR	ENST00000379619	ENST00000542478	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
In-frame	ENST00000264716	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
5CDS-intron	ENST00000264716	ENST00000543024	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
5CDS-intron	ENST00000264716	ENST00000537606	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
5CDS-5UTR	ENST00000264716	ENST00000542478	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-3CDS	ENST00000545753	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-intron	ENST00000545753	ENST00000543024	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-intron	ENST00000545753	ENST00000537606	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-5UTR	ENST00000545753	ENST00000542478	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+
intron-3CDS	ENST00000460736	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-intron	ENST00000460736	ENST00000543024	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-intron	ENST00000460736	ENST00000537606	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-5UTR	ENST00000460736	ENST00000542478	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-3CDS	ENST00000379619	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-intron	ENST00000379619	ENST00000543024	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-intron	ENST00000379619	ENST00000537606	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-5UTR	ENST00000379619	ENST00000542478	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
In-frame	ENST00000264716	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
5CDS-intron	ENST00000264716	ENST00000543024	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
5CDS-intron	ENST00000264716	ENST00000537606	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
5CDS-5UTR	ENST00000264716	ENST00000542478	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-3CDS	ENST00000545753	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-intron	ENST00000545753	ENST00000543024	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-intron	ENST00000545753	ENST00000537606	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+
intron-5UTR	ENST00000545753	ENST00000542478	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000264716

FOSL2

chr2

28616689

ENST00000233575

SNX17

chr2

27594136

2724

965

704

2314

536

ENST00000264716

FOSL2

chr2

28616689

ENST00000233575

SNX17

chr2

27594135

2724

965

704

2314

536

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264716	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594136	+	0.008628864	0.99137115
ENST00000264716	ENST00000233575	FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+	0.008628864	0.99137115

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Fusion Genomic Features for FOSL2-SNX17

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+	0.013239862	0.98676014
FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+	0.013239862	0.98676014
FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+	0.013239862	0.98676014
FOSL2	chr2	28616689	+	SNX17	chr2	27594135	+	0.013239862	0.98676014

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FOSL2-SNX17

Go to
FGviewer for the breakpoints of chr2:28616689-chr2:27594136
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FOSL2 P15408	.
FUNCTION: Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SNX17

chr2:28616689

chr2:27594135

ENST00000233575

115_206

21.0

471.0

Domain

Ras-associating

Tgene

SNX17

chr2:28616689

chr2:27594135

ENST00000537606

115_206

446.0

Domain

Ras-associating

Tgene

SNX17

chr2:28616689

chr2:27594135

ENST00000537606

1_109

446.0

Domain

Tgene

SNX17

chr2:28616689

chr2:27594136

ENST00000233575

115_206

21.0

471.0

Domain

Ras-associating

Tgene

SNX17

chr2:28616689

chr2:27594136

ENST00000537606

115_206

446.0

Domain

Ras-associating

Tgene

SNX17

chr2:28616689

chr2:27594136

ENST00000537606

1_109

446.0

Domain

Tgene

SNX17

chr2:28616689

chr2:27594135

ENST00000233575

115_432

21.0

471.0

Region

Note=FERM-like

Tgene

SNX17

chr2:28616689

chr2:27594135

ENST00000233575

270_432

21.0

471.0

Region

Note=PTB-like F3 module

Tgene

SNX17

chr2:28616689

chr2:27594135

ENST00000537606

115_432

446.0

Region

Note=FERM-like

Tgene

SNX17

chr2:28616689

chr2:27594135

ENST00000537606

270_432

446.0

Region

Note=PTB-like F3 module

Tgene

SNX17

chr2:28616689

chr2:27594136

ENST00000233575

115_432

21.0

471.0

Region

Note=FERM-like

Tgene

SNX17

chr2:28616689

chr2:27594136

ENST00000233575

270_432

21.0

471.0

Region

Note=PTB-like F3 module

Tgene

SNX17

chr2:28616689

chr2:27594136

ENST00000537606

115_432

446.0

Region

Note=FERM-like

Tgene

SNX17

chr2:28616689

chr2:27594136

ENST00000537606

270_432

446.0

Region

Note=PTB-like F3 module

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FOSL2

chr2:28616689

chr2:27594135

ENST00000264716

124_187

34.0

327.0

Domain

bZIP

Hgene

FOSL2

chr2:28616689

chr2:27594135

ENST00000379619

124_187

319.0

Domain

bZIP

Hgene

FOSL2

chr2:28616689

chr2:27594135

ENST00000545753

124_187

288.0

Domain

bZIP

Hgene

FOSL2

chr2:28616689

chr2:27594136

ENST00000264716

124_187

34.0

327.0

Domain

bZIP

Hgene

FOSL2

chr2:28616689

chr2:27594136

ENST00000379619

124_187

319.0

Domain

bZIP

Hgene

FOSL2

chr2:28616689

chr2:27594136

ENST00000545753

124_187

288.0

Domain

bZIP

Hgene

FOSL2

chr2:28616689

chr2:27594135

ENST00000264716

126_128

34.0

327.0

Region

Basic motif

Hgene

FOSL2

chr2:28616689

chr2:27594135

ENST00000264716

129_136

34.0

327.0

Region

Leucine-zipper

Hgene

FOSL2

chr2:28616689

chr2:27594135

ENST00000379619

126_128

319.0

Region

Basic motif

Hgene

FOSL2

chr2:28616689

chr2:27594135

ENST00000379619

129_136

319.0

Region

Leucine-zipper

Hgene

FOSL2

chr2:28616689

chr2:27594135

ENST00000545753

126_128

288.0

Region

Basic motif

Hgene

FOSL2

chr2:28616689

chr2:27594135

ENST00000545753

129_136

288.0

Region

Leucine-zipper

Hgene

FOSL2

chr2:28616689

chr2:27594136

ENST00000264716

126_128

34.0

327.0

Region

Basic motif

Hgene

FOSL2

chr2:28616689

chr2:27594136

ENST00000264716

129_136

34.0

327.0

Region

Leucine-zipper

Hgene

FOSL2

chr2:28616689

chr2:27594136

ENST00000379619

126_128

319.0

Region

Basic motif

Hgene

FOSL2

chr2:28616689

chr2:27594136

ENST00000379619

129_136

319.0

Region

Leucine-zipper

Hgene

FOSL2

chr2:28616689

chr2:27594136

ENST00000545753

126_128

288.0

Region

Basic motif

Hgene

FOSL2

chr2:28616689

chr2:27594136

ENST00000545753

129_136

288.0

Region

Leucine-zipper

Tgene

SNX17

chr2:28616689

chr2:27594135

ENST00000233575

1_109

21.0

471.0

Domain

Tgene

SNX17

chr2:28616689

chr2:27594136

ENST00000233575

1_109

21.0

471.0

Domain

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Fusion Gene Sequence for FOSL2-SNX17

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000264716_ENST00000233575_TCGA-61-1738-01A_FOSL2_chr2_28616689_+_SNX17_chr2_27594136_length(transcript)=2724nt_BP=965nt
GTAGTGACTCATCTCGGGCAGAGCGCTAGGGCTCCGAGCGAACCAGCGAGCGAGCGAACGAGCGGCGCTCGGCGGGGACAGAAAGAGGGA
GAGAGAGAGAGAGAGAGAGGGAGAGGCGCGGCCGGGCGAGGCGGGCCCGTCCGGGAGCGGGCTCCGGGGAAGGGGTGCGGGTCTGGGCGC
CGGAGCGGGGAGCGGGGCCGCGTCCCTCTCAGCGCCAGCTCTACTTGAGCCCCACGAGCCGCTGTCCCCCTGGCGCGCTCGGGGCCGCGG
GACGGGCGCACGCCGCCTTCTCCTAGTCAAGTATCCGAGCCGCCCCGAAACTCGGGCGGCGAGTCGGCCACGGGAAGTTTATTCTCCGGC
TCCTTTTCTAAAAGGAAGAAACAGAAGTTTCTCCCAGCGGACAGCTTTTCTTTCCGCCTTTTTGGCCCTGTCTGAAATCGGGGGTCCCCA
GGGCTGGCAGGCCAGGCTCGCTGGGCTCCTAATCTTTTTTTTAATTTCCAATTTTTGATTGGGCCGTGGGTCCCCGCTGAGCTCCGGCTG
CGCGCGGGGGCGGGAGGGCGCGCGCAGGGGAGGGACCGAGAGACGCGCCGACTTTTTAGAGGGAGGGATCGGGTGGACAACTGGTCCCGC
GGCGCTCGCAGAGCCGGAAAGAAGTGCTGTAAGGGACGCTCGGGGGACGCTGTTCCTGAGGTGTCGCCGCCTCCCTGTCCTCGCCCTCCG
CGGTGGGGGAGAAACCCAGGAGCGAAGCCCAGAGCCCGCGGCGCGGCCGGCGGACGAACGAGCGCGCAGCAGCCGGTGCGCGGCCGCGGC
GAGGGCGGGGGAAGAAAAACACCCTGTTTCCTCTCCGGCCCCCACCGCGGATCATGTACCAGGATTATCCCGGGAACTTTGACACCTCGT
CCCGGGGCAGCAGCGGCTCTCCTGCGCACGCCGAGTCCTACTCCAGCGGCGGCGGCGGCCAGCAGGCCTATAACATTCACGTGAATGGAG
TCCTGCACTGTCGGGTGCGCTACAGCCAGCTCCTGGGGCTGCACGAGCAGCTTCGGAAGGAGTATGGGGCCAATGTGCTTCCTGCATTCC
CCCCAAAGAAGCTTTTCTCTCTGACTCCTGCTGAGGTAGAACAGAGGAGAGAGCAGTTAGAGAAGTACATGCAAGCTGTTCGGCAAGACC
CATTGCTTGGGAGCAGCGAGACTTTCAACAGTTTCCTGCGTCGGGCACAACAGGAGACACAGCAGGTCCCCACAGAGGAAGTGTCCTTGG
AAGTGCTGCTCAGCAACGGGCAGAAAGTTCTGGTCAACGTGCTAACTTCAGATCAGACTGAGGATGTCCTGGAGGCTGTAGCTGCAAAGC
TGGATCTTCCAGATGACTTGATTGGATACTTTAGTCTATTCTTAGTTCGAGAAAAAGAGGATGGAGCCTTTTCTTTTGTACGGAAGTTGC
AAGAGTTTGAGCTGCCTTATGTGTCTGTCACCAGCCTTCGGAGTCAAGAGTATAAGATTGTGCTAAGGAAGAGTTATTGGGACTCTGCCT
ATGATGACGATGTCATGGAGAACCGGGTTGGCCTGAACCTGCTTTATGCTCAGACGGTATCAGATATTGAGCGTGGGTGGATCTTGGTCA
CCAAGGAACAGCACCGGCAACTCAAATCTCTGCAAGAGAAAGTCTCCAAGAAGGAGTTCCTGAGACTGGCCCAGACGCTGCGGCACTATG
GCTACTTGCGCTTTGATGCCTGTGTGGCTGACTTCCCAGAAAAGGACTGTCCTGTGGTGGTGAGCGCGGGCAACAGTGAGCTCAGCCTGC
AGCTCCGCCTGCCTGGCCAGCAACTCCGAGAAGGCTCCTTCCGGGTCACCCGCATGCGATGCTGGCGGGTCACCTCCTCTGTACCATTGC
CCAGTGGAAGCACGAGCAGCCCAGGCCGGGGCCGGGGTGAGGTGCGCCTGGAACTGGCTTTTGAATACCTCATGAGCAAGGACCGGCTAC
AGTGGGTCACCATCACTAGCCCCCAGGCTATCATGATGAGCATCTGCTTGCAGTCCATGGTTGATGAACTGATGGTGAAGAAATCTGGCG
GCAGTATCAGGAAGATGCTGCGCCGGCGGGTGGGGGGTACTCTGAGACGCTCAGACAGCCAGCAAGCAGTGAAGTCCCCACCACTGCTTG
AGTCACCTGATGCCACCCGGGAGTCTATGGTCAAACTCTCAAGTAAGCTGAGTGCCGTGAGCTTGCGGGGAATTGGCAGTCCCAGCACAG
ATGCCAGTGCCAGTGATGTCCACGGCAATTTCGCCTTCGAGGGCATTGGAGATGAGGATCTGTAATCTCCACTGCTTGGATGTCTGCCCT
CTACCCCAGAGGAATTTACAGAAACTTGCCCTGTGCCTGTGTCCCCCATGCTAGGGGCGGAGGGGTCTTTTCCTTCTTCTTTCCTACCTA
CCCCTTTTCTCTTGGCCAGGGGCCTCGTATCCTACCTTTCCTTGTCCCCTGGGCTGGCTGCACAGAGGATTGCCCCTTCTCTTTTCAGAG
CTGGCCCTCGATGCCAAATTAGCATTTAGTATTTTGCACAAAGTCTAAGGGACCATGGCTGCCTGCCTTGGGGAGGAACCATATCTCCCT
CTGGGCCGCTTCTGGCCTCTTGGAGCCATGGGCCAAAGGCCAAGGGGATGGGCAGAGGTCTGTGTTTGGTCTGGCCCAGTTCCCCATCAT

>In-frame_ENST00000264716_ENST00000233575_TCGA-61-1738-01A_FOSL2_chr2_28616689_+_SNX17_chr2_27594136_length(amino acids)=536AA_start in transcript=704_stop in transcript=2314
MSSPSAVGEKPRSEAQSPRRGRRTNERAAAGARPRRGRGKKNTLFPLRPPPRIMYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQAYN
IHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPT
EEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKS
YWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGN
SELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELM

--------------------------------------------------------------
>In-frame_ENST00000264716_ENST00000233575_TCGA-61-1738_FOSL2_chr2_28616689_+_SNX17_chr2_27594135_length(transcript)=2724nt_BP=965nt
GTAGTGACTCATCTCGGGCAGAGCGCTAGGGCTCCGAGCGAACCAGCGAGCGAGCGAACGAGCGGCGCTCGGCGGGGACAGAAAGAGGGA
GAGAGAGAGAGAGAGAGAGGGAGAGGCGCGGCCGGGCGAGGCGGGCCCGTCCGGGAGCGGGCTCCGGGGAAGGGGTGCGGGTCTGGGCGC
CGGAGCGGGGAGCGGGGCCGCGTCCCTCTCAGCGCCAGCTCTACTTGAGCCCCACGAGCCGCTGTCCCCCTGGCGCGCTCGGGGCCGCGG
GACGGGCGCACGCCGCCTTCTCCTAGTCAAGTATCCGAGCCGCCCCGAAACTCGGGCGGCGAGTCGGCCACGGGAAGTTTATTCTCCGGC
TCCTTTTCTAAAAGGAAGAAACAGAAGTTTCTCCCAGCGGACAGCTTTTCTTTCCGCCTTTTTGGCCCTGTCTGAAATCGGGGGTCCCCA
GGGCTGGCAGGCCAGGCTCGCTGGGCTCCTAATCTTTTTTTTAATTTCCAATTTTTGATTGGGCCGTGGGTCCCCGCTGAGCTCCGGCTG
CGCGCGGGGGCGGGAGGGCGCGCGCAGGGGAGGGACCGAGAGACGCGCCGACTTTTTAGAGGGAGGGATCGGGTGGACAACTGGTCCCGC
GGCGCTCGCAGAGCCGGAAAGAAGTGCTGTAAGGGACGCTCGGGGGACGCTGTTCCTGAGGTGTCGCCGCCTCCCTGTCCTCGCCCTCCG
CGGTGGGGGAGAAACCCAGGAGCGAAGCCCAGAGCCCGCGGCGCGGCCGGCGGACGAACGAGCGCGCAGCAGCCGGTGCGCGGCCGCGGC
GAGGGCGGGGGAAGAAAAACACCCTGTTTCCTCTCCGGCCCCCACCGCGGATCATGTACCAGGATTATCCCGGGAACTTTGACACCTCGT
CCCGGGGCAGCAGCGGCTCTCCTGCGCACGCCGAGTCCTACTCCAGCGGCGGCGGCGGCCAGCAGGCCTATAACATTCACGTGAATGGAG
TCCTGCACTGTCGGGTGCGCTACAGCCAGCTCCTGGGGCTGCACGAGCAGCTTCGGAAGGAGTATGGGGCCAATGTGCTTCCTGCATTCC
CCCCAAAGAAGCTTTTCTCTCTGACTCCTGCTGAGGTAGAACAGAGGAGAGAGCAGTTAGAGAAGTACATGCAAGCTGTTCGGCAAGACC
CATTGCTTGGGAGCAGCGAGACTTTCAACAGTTTCCTGCGTCGGGCACAACAGGAGACACAGCAGGTCCCCACAGAGGAAGTGTCCTTGG
AAGTGCTGCTCAGCAACGGGCAGAAAGTTCTGGTCAACGTGCTAACTTCAGATCAGACTGAGGATGTCCTGGAGGCTGTAGCTGCAAAGC
TGGATCTTCCAGATGACTTGATTGGATACTTTAGTCTATTCTTAGTTCGAGAAAAAGAGGATGGAGCCTTTTCTTTTGTACGGAAGTTGC
AAGAGTTTGAGCTGCCTTATGTGTCTGTCACCAGCCTTCGGAGTCAAGAGTATAAGATTGTGCTAAGGAAGAGTTATTGGGACTCTGCCT
ATGATGACGATGTCATGGAGAACCGGGTTGGCCTGAACCTGCTTTATGCTCAGACGGTATCAGATATTGAGCGTGGGTGGATCTTGGTCA
CCAAGGAACAGCACCGGCAACTCAAATCTCTGCAAGAGAAAGTCTCCAAGAAGGAGTTCCTGAGACTGGCCCAGACGCTGCGGCACTATG
GCTACTTGCGCTTTGATGCCTGTGTGGCTGACTTCCCAGAAAAGGACTGTCCTGTGGTGGTGAGCGCGGGCAACAGTGAGCTCAGCCTGC
AGCTCCGCCTGCCTGGCCAGCAACTCCGAGAAGGCTCCTTCCGGGTCACCCGCATGCGATGCTGGCGGGTCACCTCCTCTGTACCATTGC
CCAGTGGAAGCACGAGCAGCCCAGGCCGGGGCCGGGGTGAGGTGCGCCTGGAACTGGCTTTTGAATACCTCATGAGCAAGGACCGGCTAC
AGTGGGTCACCATCACTAGCCCCCAGGCTATCATGATGAGCATCTGCTTGCAGTCCATGGTTGATGAACTGATGGTGAAGAAATCTGGCG
GCAGTATCAGGAAGATGCTGCGCCGGCGGGTGGGGGGTACTCTGAGACGCTCAGACAGCCAGCAAGCAGTGAAGTCCCCACCACTGCTTG
AGTCACCTGATGCCACCCGGGAGTCTATGGTCAAACTCTCAAGTAAGCTGAGTGCCGTGAGCTTGCGGGGAATTGGCAGTCCCAGCACAG
ATGCCAGTGCCAGTGATGTCCACGGCAATTTCGCCTTCGAGGGCATTGGAGATGAGGATCTGTAATCTCCACTGCTTGGATGTCTGCCCT
CTACCCCAGAGGAATTTACAGAAACTTGCCCTGTGCCTGTGTCCCCCATGCTAGGGGCGGAGGGGTCTTTTCCTTCTTCTTTCCTACCTA
CCCCTTTTCTCTTGGCCAGGGGCCTCGTATCCTACCTTTCCTTGTCCCCTGGGCTGGCTGCACAGAGGATTGCCCCTTCTCTTTTCAGAG
CTGGCCCTCGATGCCAAATTAGCATTTAGTATTTTGCACAAAGTCTAAGGGACCATGGCTGCCTGCCTTGGGGAGGAACCATATCTCCCT
CTGGGCCGCTTCTGGCCTCTTGGAGCCATGGGCCAAAGGCCAAGGGGATGGGCAGAGGTCTGTGTTTGGTCTGGCCCAGTTCCCCATCAT

>In-frame_ENST00000264716_ENST00000233575_TCGA-61-1738_FOSL2_chr2_28616689_+_SNX17_chr2_27594135_length(amino acids)=536AA_start in transcript=704_stop in transcript=2314
MSSPSAVGEKPRSEAQSPRRGRRTNERAAAGARPRRGRGKKNTLFPLRPPPRIMYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQAYN
IHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPT
EEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKS
YWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGN
SELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELM

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Fusion Gene PPI Analysis for FOSL2-SNX17

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FOSL2-SNX17

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for FOSL2-SNX17

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FOSL2	C0017636	Glioblastoma	1	CTD_human
Hgene	FOSL2	C0024121	Lung Neoplasms	1	CTD_human
Hgene	FOSL2	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Hgene	FOSL2	C0242379	Malignant neoplasm of lung	1	CTD_human
Hgene	FOSL2	C0334588	Giant Cell Glioblastoma	1	CTD_human
Hgene	FOSL2	C1621958	Glioblastoma Multiforme	1	CTD_human
Hgene	FOSL2	C3495559	Juvenile arthritis	1	CTD_human
Hgene	FOSL2	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Hgene	FOSL2	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Hgene	FOSL2	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human