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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FOXK2-ABCA5 (FusionGDB2 ID:30991)

Fusion Gene Summary for FOXK2-ABCA5

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXK2-ABCA5
Fusion gene ID: 30991
HgeneTgene
Gene symbol

FOXK2

ABCA5

Gene ID

3607

23461

Gene nameforkhead box K2ATP binding cassette subfamily A member 5
SynonymsILF|ILF-1|ILF1|nGTBPABC13|EST90625|HTC3
Cytomap

17q25.3

17q24.3

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein K2FOXK1G/T-mismatch specific binding proteincellular transcription factor ILF-1interleukin enhancer-binding factor 1ATP-binding cassette sub-family A member 5ATP-binding cassette A5ATP-binding cassette, sub-family A (ABC1), member 5
Modification date2020031320200313
UniProtAcc

Q01167

Q8WWZ7

Ensembl transtripts involved in fusion geneENST00000335255, ENST00000529652, 
ENST00000392676, ENST00000392677, 
ENST00000588877, ENST00000589609, 
Fusion gene scores* DoF score31 X 14 X 13=56425 X 6 X 3=90
# samples 345
** MAII scorelog2(34/5642*10)=-4.05260001444787
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOXK2 [Title/Abstract] AND ABCA5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOXK2(80542064)-ABCA5(67273983), # samples:3
Anticipated loss of major functional domain due to fusion event.FOXK2-ABCA5 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
FOXK2-ABCA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FOXK2-ABCA5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXK2

GO:0045892

negative regulation of transcription, DNA-templated

20810654|25451922

HgeneFOXK2

GO:0045893

positive regulation of transcription, DNA-templated

22083952

HgeneFOXK2

GO:0045944

positive regulation of transcription by RNA polymerase II

9065434


check buttonFusion gene breakpoints across FOXK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCA5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27N-01AFOXK2chr17

80542064

+ABCA5chr17

67273983

-
ChimerDB4BRCATCGA-D8-A27N-01AFOXK2chr17

80542064

+ABCA5chr17

67273983

-
ChimerDB4BRCATCGA-D8-A27N-01AFOXK2chr17

80542064

+ABCA5chr17

67270269

-
ChimerDB4BRCATCGA-D8-A27N-01AFOXK2chr17

80542064

-ABCA5chr17

67273983

-


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Fusion Gene ORF analysis for FOXK2-ABCA5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000335255ENST00000392676FOXK2chr17

80542064

+ABCA5chr17

67273983

-
In-frameENST00000335255ENST00000392677FOXK2chr17

80542064

+ABCA5chr17

67273983

-
In-frameENST00000335255ENST00000588877FOXK2chr17

80542064

+ABCA5chr17

67273983

-
5CDS-intronENST00000335255ENST00000589609FOXK2chr17

80542064

+ABCA5chr17

67273983

-
intron-3CDSENST00000529652ENST00000392676FOXK2chr17

80542064

+ABCA5chr17

67273983

-
intron-3CDSENST00000529652ENST00000392677FOXK2chr17

80542064

+ABCA5chr17

67273983

-
intron-3CDSENST00000529652ENST00000588877FOXK2chr17

80542064

+ABCA5chr17

67273983

-
intron-intronENST00000529652ENST00000589609FOXK2chr17

80542064

+ABCA5chr17

67273983

-
Frame-shiftENST00000335255ENST00000392676FOXK2chr17

80542064

+ABCA5chr17

67270269

-
Frame-shiftENST00000335255ENST00000392677FOXK2chr17

80542064

+ABCA5chr17

67270269

-
Frame-shiftENST00000335255ENST00000588877FOXK2chr17

80542064

+ABCA5chr17

67270269

-
5CDS-intronENST00000335255ENST00000589609FOXK2chr17

80542064

+ABCA5chr17

67270269

-
intron-3CDSENST00000529652ENST00000392676FOXK2chr17

80542064

+ABCA5chr17

67270269

-
intron-3CDSENST00000529652ENST00000392677FOXK2chr17

80542064

+ABCA5chr17

67270269

-
intron-3CDSENST00000529652ENST00000588877FOXK2chr17

80542064

+ABCA5chr17

67270269

-
intron-intronENST00000529652ENST00000589609FOXK2chr17

80542064

+ABCA5chr17

67270269

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000335255FOXK2chr1780542064+ENST00000392676ABCA5chr1767273983-7216145311139891292
ENST00000335255FOXK2chr1780542064+ENST00000392677ABCA5chr1767273983-7095145311139921293
ENST00000335255FOXK2chr1780542064+ENST00000588877ABCA5chr1767273983-4576145311139891292

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335255ENST00000392676FOXK2chr1780542064+ABCA5chr1767273983-4.77E-050.9999523
ENST00000335255ENST00000392677FOXK2chr1780542064+ABCA5chr1767273983-2.90E-050.99997103
ENST00000335255ENST00000588877FOXK2chr1780542064+ABCA5chr1767273983-0.0001627850.99983716

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Fusion Genomic Features for FOXK2-ABCA5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FOXK2-ABCA5


check button Go to

FGviewer for the breakpoints of chr17:80542064-chr17:67273983

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXK2

Q01167

ABCA5

Q8WWZ7

FUNCTION: Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:22083952, PubMed:25451922). Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (PubMed:22083952). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (PubMed:20097901). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (PubMed:1339390). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (PubMed:25805136). Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements (PubMed:1909027). {ECO:0000250|UniProtKB:Q3UCQ1, ECO:0000269|PubMed:1339390, ECO:0000269|PubMed:1909027, ECO:0000269|PubMed:20097901, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:25451922, ECO:0000269|PubMed:25805136}.FUNCTION: Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity). {ECO:0000250|UniProtKB:Q8K448, ECO:0000269|PubMed:25125465}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXK2chr17:80542064chr17:67273983ENST00000335255+6910_93426.3333333333333661.0Compositional biasNote=Gly-rich
HgeneFOXK2chr17:80542064chr17:67273983ENST00000335255+69258_353426.3333333333333661.0DNA bindingFork-head
HgeneFOXK2chr17:80542064chr17:67273983ENST00000335255+6954_128426.3333333333333661.0DomainFHA
HgeneFOXK2chr17:80542064chr17:67273983ENST00000335255+69300_318426.3333333333333661.0RegionDNA-binding%3B major groove
HgeneFOXK2chr17:80542064chr17:67273983ENST00000335255+69328_332426.3333333333333661.0RegionDNA-binding%3B minor groove
HgeneFOXK2chr17:80542064chr17:67273983ENST00000335255+69348_353426.3333333333333661.0RegionDNA-binding%3B minor groove
TgeneABCA5chr17:80542064chr17:67273983ENST0000039267617391290_1533797.33333333333341643.0DomainABC transporter 2
TgeneABCA5chr17:80542064chr17:67273983ENST0000058887716381290_1533797.33333333333341643.0DomainABC transporter 2
TgeneABCA5chr17:80542064chr17:67273983ENST0000039267617391333_1340797.33333333333341643.0Nucleotide bindingATP 2
TgeneABCA5chr17:80542064chr17:67273983ENST0000058887716381333_1340797.33333333333341643.0Nucleotide bindingATP 2
TgeneABCA5chr17:80542064chr17:67273983ENST0000039267617391021_1041797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000039267617391071_1091797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000039267617391102_1122797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000039267617391139_1159797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000039267617391169_1189797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000039267617391207_1227797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739866_886797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739967_987797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000058887716381021_1041797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000058887716381071_1091797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000058887716381102_1122797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000058887716381139_1159797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000058887716381169_1189797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST0000058887716381207_1227797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638866_886797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638967_987797.33333333333341643.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739478_713797.33333333333341643.0DomainABC transporter 1
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638478_713797.33333333333341643.0DomainABC transporter 1
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739514_521797.33333333333341643.0Nucleotide bindingATP 1
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638514_521797.33333333333341643.0Nucleotide bindingATP 1
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739220_240797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739264_284797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739297_317797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739328_348797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST00000392676173932_52797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739355_375797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000003926761739396_416797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638220_240797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638264_284797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638297_317797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638328_348797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST00000588877163832_52797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638355_375797.33333333333341643.0TransmembraneHelical
TgeneABCA5chr17:80542064chr17:67273983ENST000005888771638396_416797.33333333333341643.0TransmembraneHelical


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Fusion Gene Sequence for FOXK2-ABCA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000335255_ENST00000392676_TCGA-D8-A27N-01A_FOXK2_chr17_80542064_+_ABCA5_chr17_67273983_length(transcript)=7216nt_BP=1453nt
CGGCCGCGCGTGCTCCCGCCCCTCGCCGCCGCTCGCTCGCTCGCCGGCCGGCGGCCTCCGCTCGGCCCCCTCCCTCAGCTCCGGTGCGCG
GCGGCCGACGACCCGCGCGGCCTGGGCCTCGGCCCGCGCCACCGGCGCCCGCGCGGAGCGGCCCGGGGGCCCTCACGCAGGCCCATGGCG
GCGGCCGCGGCGGCGCTCTCGGGCGCGGGCACGCCACCCGCGGGCGGCGGGGCCGGGGGCGGCGGGGCCGGGGGCGGCGGGTCCCCGCCG
GGCGGCTGGGCCGTGGCGCGCCTGGAGGGCCGCGAGTTCGAGTATCTGATGAAGAAGCGCTCGGTGACCATCGGCCGCAACTCGTCGCAG
GGCTCGGTGGACGTGAGCATGGGCCACTCGAGCTTCATCTCCCGGCGCCACCTCGAGATCTTCACGCCCCCGGGCGGCGGCGGCCATGGC
GGGGCCGCTCCGGAGCTGCCGCCCGCGCAGCCCAGGCCCGACGCCGGCGGCGACTTCTACCTGCGCTGCTTGGGCAAGAACGGGGTATTC
GTGGACGGCGTGTTCCAGAGGCGCGGGGCGCCGCCGCTGCAGCTGCCGCGCGTGTGCACATTCAGGTTCCCGAGCACAAACATCAAGATA
ACGTTCACTGCCCTGTCCAGCGAGAAGAGAGAGAAGCAGGAGGCGTCTGAGTCTCCAGTGAAGGCCGTACAGCCACACATCTCGCCCCTG
ACCATCAACATTCCAGACACCATGGCCCACCTCATCAGCCCTCTGCCCTCCCCCACGGGAACCATCAGCGCTGCAAACTCCTGCCCCTCC
AGCCCCCGGGGAGCGGGGTCTTCAGGGTACAAGGTGGGCCGAGTGATGCCATCTGACCTCAATTTAATGGCTGACAACTCACAGCCTGAA
AATGAAAAGGAAGCTTCAGGTGGAGACAGCCCGAAGGATGATTCAAAGCCGCCTTACTCCTACGCGCAGCTGATAGTTCAGGCGATTACG
ATGGCTCCCGACAAACAGCTCACCCTGAACGGGATTTATACACACATCACTAAAAATTATCCCTACTACAGGACTGCGGACAAGGGCTGG
CAGAATTCAATTCGCCACAATCTCTCTCTGAATCGTTATTTCATCAAAGTGCCGCGTTCCCAGGAAGAACCAGGCAAAGGCTCGTTCTGG
AGGATAGACCCAGCCTCTGAAAGCAAATTAATAGAACAGGCTTTTAGGAAACGACGGCCTAGGGGCGTGCCCTGCTTTAGAACCCCTCTG
GGACCGCTCTCTTCTAGGAGTGCCCCAGCCTCTCCCAATCACGCGGGAGTGCTGTCTGCTCACTCTAGTGGCGCCCAGACCCCTGAGAGC
CTGTCGAGGGAAGGTTCGCCGGCCCCCCTGGAGCCTGAGCCTGGCGCTGCACAGCCCAAACTCGCTGTCATCCAGGAAGCCCGGTTTGCC
CAGAGCGCCCCAGATTATAGTGTATTTACTCAGCAGCCACTGGAGGAAGAAATGGATTCAAAATCTTTTGATGAAATGGAACAGAGCTTA
CTTATTCTTTCTGAAACCAAGGCTGCTCTAGTGAGCACCATGAGCCTTTGGAAACAACAGATGTATACAATAGCAAAGTTTCATTTCTTT
ACCTTGAAACGTGAAAGTAAATCAGTGAGATCAGTGTTGCTTCTGCTTTTAATTTTTTTCACAGTTCAGATTTTTATGTTTTTGGTTCAT
CACTCTTTTAAAAATGCTGTGGTTCCCATCAAACTTGTTCCAGACTTATATTTTCTAAAACCTGGAGACAAACCACATAAATACAAAACA
AGTCTGCTTCTTCAAAATTCTGCTGACTCAGATATCAGTGATCTTATTAGCTTTTTCACAAGCCAGAACATAATGGTGACGATGATTAAT
GACAGTGACTATGTATCCGTGGCTCCCCATAGTGCGGCTTTAAATGTGATGCATTCAGAAAAGGACTATGTTTTTGCAGCTGTTTTCAAC
AGTACTATGGTTTATTCTTTACCTATATTAGTGAATATCATTAGTAACTACTATCTTTATCATTTAAATGTGACTGAAACCATCCAGATC
TGGAGTACCCCATTCTTTCAAGAAATTACTGATATAGTTTTTAAAATTGAGCTGTATTTTCAAGCAGCTTTGCTTGGAATCATTGTTACT
GCAATGCCACCTTACTTTGCCATGGAAAATGCAGAGAATCATAAGATCAAAGCTTATACTCAACTTAAACTTTCAGGTCTTTTGCCATCT
GCATATTGGATTGGACAAGCTGTTGTTGATATCCCCTTATTTTTTATCATTCTTATTTTGATGCTAGGAAGCTTATTGGCATTTCATTAT
GGATTATATTTTTATACTGTAAAGTTCCTTGCTGTGGTTTTTTGCCTTATTGGTTATGTTCCATCAGTTATTCTGTTCACTTATATTGCT
TCTTTCACCTTTAAGAAAATTTTAAATACCAAAGAATTTTGGTCATTTATCTATTCTGTGGCAGCGTTGGCTTGTATTGCAATCACTGAA
ATAACTTTCTTTATGGGATACACAATTGCAACTATTCTTCATTATGCCTTTTGTATCATCATTCCAATCTATCCACTTCTAGGTTGCCTG
ATTTCTTTCATAAAGATTTCTTGGAAGAATGTACGAAAAAATGTGGACACCTATAATCCATGGGATAGGCTTTCAGTAGCTGTTATATCG
CCTTACCTGCAGTGTGTACTGTGGATTTTCCTCTTACAATACTATGAGAAAAAATATGGAGGCAGATCAATAAGAAAAGATCCCTTTTTC
AGAAACCTTTCAACGAAGTCTAAAAATAGGAAGCTTCCAGAACCACCAGACAATGAGGATGAAGATGAAGATGTCAAAGCTGAAAGACTA
AAGGTCAAAGAGCTGATGGGTTGCCAGTGTTGTGAGGAGAAACCATCCATTATGGTCAGCAATTTGCATAAAGAATATGATGACAAGAAA
GATTTTCTTCTTTCAAGAAAAGTAAAGAAAGTGGCAACTAAATACATCTCTTTCTGTGTGAAAAAAGGAGAGATCTTAGGACTATTGGGT
CCAAATGGTGCTGGCAAAAGCACAATTATTAATATTCTGGTTGGTGATATTGAACCAACTTCAGGCCAGGTATTTTTAGGAGATTATTCT
TCAGAGACAAGTGAAGATGATGATTCACTGAAGTGTATGGGTTACTGTCCTCAGATAAACCCTTTGTGGCCAGATACTACATTGCAGGAA
CATTTTGAAATTTATGGAGCTGTCAAAGGAATGAGTGCAAGTGACATGAAAGAAGTCATAAGTCGAATAACACATGCACTTGATTTAAAA
GAACATCTTCAGAAGACTGTAAAGAAACTACCTGCAGGAATCAAACGAAAGTTGTGTTTTGCTCTAAGTATGCTAGGGAATCCTCAGATT
ACTTTGCTAGATGAACCATCTACAGGTATGGATCCCAAAGCCAAACAGCACATGTGGCGAGCAATTCGAACTGCATTTAAAAACAGAAAG
CGGGCTGCTATTCTGACCACTCACTATATGGAGGAGGCAGAGGCTGTCTGTGATCGAGTAGCTATCATGGTGTCTGGGCAGTTAAGATGT
ATCGGAACAGTACAACATCTAAAGAGTAAATTTGGAAAAGGCTACTTTTTGGAAATTAAATTGAAGGACTGGATAGAAAACCTAGAAGTA
GACCGCCTTCAAAGAGAAATTCAGTATATTTTCCCAAATGCAAGCCGTCAGGAAAGTTTTTCTTCTATTTTGGCTTATAAAATTCCTAAG
GAAGATGTTCAGTCCCTTTCACAATCTTTTTTTAAGCTGGAAGAAGCTAAACATGCTTTTGCCATTGAAGAATATAGCTTTTCTCAAGCA
ACATTGGAACAGGTTTTTGTAGAACTCACTAAAGAACAAGAGGAGGAAGATAATAGTTGTGGAACTTTAAACAGCACACTTTGGTGGGAA
CGAACACAAGAAGATAGAGTAGTATTTTGAATTTGTATTGTTCGGTCTGCTTACTGGGACTTCTTTCTTTTTCACTTAATTTTAACTTTG
GTTTAAAAAGTTTTTTATTGGAATGGTAACTGGAGAACCAAGAACGCACTTGAAATTTTTCTAAGCTCCTTAATTGAAATGCTGTGGTTG
TGTGTTTTGCTTTTCTTTAAATAAAACGTATGTATAATTAAGTGAAGCTGCATGTTTGTATTGAAGTATATTGAACTATATAGTTTGTAT
GTCATCTTTTTCACCATTCAGAAACAGTGCTTCTGAATTTGTGATTTAAAGGAATTGTAATAGAATAGTTTTATTTTTAAGTTATCTTTA
AGTTTATGCCATCTTCTTAAATAAGTACGTAATGTTCCAATCTAAATAAAAAACTAATTCATAACTAATGCATAGAAAAGATACATAAAG
CAATGTGAAAGTTTCTTGCTTCTCCTTTTTAATTTCTAAAAAAGCCACTTTGAATGGAAGTTGTCATCCGTAAAAGCTGAAGTGTAAGCA
CTAGGAAATCTCAATATAGAGATTTGAGGAAAGTTATATCCACTAGGTGGCAGTCATTGATCATAATAAGTGAAATGAGCCCTTGTTCTA
GTACATGATTTTAGGCTTAGGTAATTAGGTATGTGAAATTACATTTCTTTAATTTAAAGTAAAATTCAGAAGGTTTTAGTTATTATAATT
AAAGGAAGACTGTGTGTAGAATCTTACGTAATAGTCTGATTCTTTGACTCTGTGGCTAGAATGACAGTTATCTATGGAGGTGGTAGAATT
AAGCCATACCTTTTCCTTCATCACTCTTGGAACATATAAATTTTTTGTCATCTTCCTTGCAAAGGGCACATTTAATTTTGTTCTTGAATA
AAATATTTTATTGGGTATTTGTTTTTATTGGTAAACTTTAGTGAATCTCTTCTATAAAATTGTAAGTAGATCAGTGTGTAGATTTATTTA
GTAACTTACCTCATTGACTTTGGAACATGGTAGGATATGAATAAACTCTTTCAAGGGTTAAATTAAGAATTGTAAGTGCAGTGCGCCTAT
TTCTTTTTAATAAGAACCAGAATTTCATTTTTGATAGAGTTAAAGGCATGGCTAATATTTTCTTAGAAATACTTCCTTGTACAACCCATG
TATTGGCTCAAGGTATAAAATAGTGTAAATAATGCTAGTTGACATTACATTTCAACCAAATGAAAGTATTAACTTCATAAAACAAATATA
TTGAGAGTGTGATTATTGTATTAGACAACAACAACAGCAATGACAGAAGGATTTGGTACTGAATTACTTTAAATAAGCAAAACCTTTCAG
TGGCATTATTCATTCTTTAATGTAGGCAAAATTTAATGAACTTTTAGCTTTATTGTGTAATAAGACATCTGTGATTTTAGGCTCTAGCAG
TGGATTTAAAAGTGTTCTTTCTCGGTACAAAGTACGTGGCTGATATTTTCCCCCATTGCTGGGGGCAGTTGCTATACACTTTCCTAAAGT
ATATATAATGTTCACATAAATACCCAGGGACCTCTTTTTTGGGATGTGCTTTTGTAATTATGTGTAACCTTGAATACTTAAGTTTAGTAA
AAGCAACAAAATTATATCTATAGTTTACTAAGGCAGTCACGAAAAAGCATAGTTTTTTTTAGAACCTGACCATCCTAAGAAAGTTATGTC
ATCTGAAGATAGAGCATGACTAATGAAGAAAATTACCTGCTTTTGCACGTAGATTTGGTAACTTTCACTTTACATTTGTGAATGTGTAAT
TGGTGCAAAGTAAATTTTTTTTCCTGCAAAGTGAAAGTTGAGTAGTCACAATCATGTTATTTATTTTGTTCATTTAGTTACTTTGCTTTT
AATGTATATGAATACATGCTCTTGTAAACAATTTTAAAAGACATTCAAATTTTTTTTTAGTTTTTATATACTCAGAATATATTTTGGTTG
TTAAATTAAATTATGTTCCCTTTTTCACAGTAACAAAATCTGACTCAGGAGAAATATAACTTAATTCTTAGGAAAACAAGGGTAAGTGAG
CTGGAAAGCAAAGGAGGCAAAAAGTGAAATATATTTATTTACAGTGTACAGTTCATGTTTATGAACATACTAATTTTAAAATGTCTTAAA
TTACTGATCTCAAAACTTTTTTCTATGTCAGTACAGATAAATAAATAAATATACATATTAGGCAAAAGCAACATCACCAACCTTATATTT
CCCATTCATGGTCAAATTTTCAAAGGAAAGTAAAAGCTGAGCTTTACTGAGTGAGTGTTTACTGACTAATAAGGCAAGAAAAAACATGAT
GAGTGTACTTTACATCTTACTTTTGTGGGCTCTTAATTTTTTTCTCTAGTTTGTTTTCAGTAAAGACAGTGGGTTTTCTTTAAAATAATT
TTTTTCTTTTAAATTTGCACAAATTATCTTAGGTCAGTATTTTGGTTTTAATCATTAAAACATTTTTAGAGTAATGTAATTTAACAAATA
TTTTAAGTGATTATGTTTCCAGAAATGGATTCTTTGGAGAGAACTCGGATGACTATCAGTTTTGGCCCTGTAAGATCGTGGAGATCTGTA
AGATAGATACTTATATAACTTACATAAAATATATATAATATATTACTTATATAACTTATATAACTAGCTATTATTTTATATAACTAACTA
TAATATGACAAATCCTTTGCTAGTAGTACTAACAACGTTTTATAGGAGCACAATTAATTTTACTTAGGATAAGTGTTGTTATTATTGTTT
TTATTGTTGTTCTGTTAGTTACTCAAAACTTCATTCTAATTGTGCCCTGAGTTTGTTAAAATACCATACTGTATTTTTGTGTAACATGTA
AATAGGCATTAATTTTTGAGAAATAGAAATGTTTATCCTTAATGTATTTTTAATTTGCTAACATTGATTTTTTATTTTCTTTCCTGAAAT
AGCTTATTTCCTAAAATGAAAGAATTTATTCTCAGATGAATAATTTTTATATCAGCTATTCTTATCAGGTAAAAGTTTAATTATTTTTTA
TTTATAATATATGTAAGCAATTCTCAATGCTGCTCTTTAAGAAAAATAAATATGATTATATTAATAATAAGCTTTAAGAGTTGAAAATTT
AAGACAAGTCATTTTGTATACTGAAGTGAATTCTTTGTTATTTAGTGCTGATAATTGAATAATGAGTAGCTCATATTAAAAATGATGCAA

>In-frame_ENST00000335255_ENST00000392676_TCGA-D8-A27N-01A_FOXK2_chr17_80542064_+_ABCA5_chr17_67273983_length(amino acids)=1292AA_start in transcript=111_stop in transcript=3989
MGLGPRHRRPRGAARGPSRRPMAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSM
GHSSFISRRHLEIFTPPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSS
EKREKQEASESPVKAVQPHISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQPENEKEASG
GDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASE
SKLIEQAFRKRRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEARFAQSAPDYS
VFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAV
VPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSL
PILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQA
VVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGY
TIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKS
KNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKS
TIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTV
KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHL
KSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFV

--------------------------------------------------------------
>In-frame_ENST00000335255_ENST00000392677_TCGA-D8-A27N-01A_FOXK2_chr17_80542064_+_ABCA5_chr17_67273983_length(transcript)=7095nt_BP=1453nt
CGGCCGCGCGTGCTCCCGCCCCTCGCCGCCGCTCGCTCGCTCGCCGGCCGGCGGCCTCCGCTCGGCCCCCTCCCTCAGCTCCGGTGCGCG
GCGGCCGACGACCCGCGCGGCCTGGGCCTCGGCCCGCGCCACCGGCGCCCGCGCGGAGCGGCCCGGGGGCCCTCACGCAGGCCCATGGCG
GCGGCCGCGGCGGCGCTCTCGGGCGCGGGCACGCCACCCGCGGGCGGCGGGGCCGGGGGCGGCGGGGCCGGGGGCGGCGGGTCCCCGCCG
GGCGGCTGGGCCGTGGCGCGCCTGGAGGGCCGCGAGTTCGAGTATCTGATGAAGAAGCGCTCGGTGACCATCGGCCGCAACTCGTCGCAG
GGCTCGGTGGACGTGAGCATGGGCCACTCGAGCTTCATCTCCCGGCGCCACCTCGAGATCTTCACGCCCCCGGGCGGCGGCGGCCATGGC
GGGGCCGCTCCGGAGCTGCCGCCCGCGCAGCCCAGGCCCGACGCCGGCGGCGACTTCTACCTGCGCTGCTTGGGCAAGAACGGGGTATTC
GTGGACGGCGTGTTCCAGAGGCGCGGGGCGCCGCCGCTGCAGCTGCCGCGCGTGTGCACATTCAGGTTCCCGAGCACAAACATCAAGATA
ACGTTCACTGCCCTGTCCAGCGAGAAGAGAGAGAAGCAGGAGGCGTCTGAGTCTCCAGTGAAGGCCGTACAGCCACACATCTCGCCCCTG
ACCATCAACATTCCAGACACCATGGCCCACCTCATCAGCCCTCTGCCCTCCCCCACGGGAACCATCAGCGCTGCAAACTCCTGCCCCTCC
AGCCCCCGGGGAGCGGGGTCTTCAGGGTACAAGGTGGGCCGAGTGATGCCATCTGACCTCAATTTAATGGCTGACAACTCACAGCCTGAA
AATGAAAAGGAAGCTTCAGGTGGAGACAGCCCGAAGGATGATTCAAAGCCGCCTTACTCCTACGCGCAGCTGATAGTTCAGGCGATTACG
ATGGCTCCCGACAAACAGCTCACCCTGAACGGGATTTATACACACATCACTAAAAATTATCCCTACTACAGGACTGCGGACAAGGGCTGG
CAGAATTCAATTCGCCACAATCTCTCTCTGAATCGTTATTTCATCAAAGTGCCGCGTTCCCAGGAAGAACCAGGCAAAGGCTCGTTCTGG
AGGATAGACCCAGCCTCTGAAAGCAAATTAATAGAACAGGCTTTTAGGAAACGACGGCCTAGGGGCGTGCCCTGCTTTAGAACCCCTCTG
GGACCGCTCTCTTCTAGGAGTGCCCCAGCCTCTCCCAATCACGCGGGAGTGCTGTCTGCTCACTCTAGTGGCGCCCAGACCCCTGAGAGC
CTGTCGAGGGAAGGTTCGCCGGCCCCCCTGGAGCCTGAGCCTGGCGCTGCACAGCCCAAACTCGCTGTCATCCAGGAAGCCCGGTTTGCC
CAGAGCGCCCCAGATTATAGTGTATTTACTCAGCAGCCACTGGAGGAAGAAATGGATTCAAAATCTTTTGATGAAATGGAACAGAGCTTA
CTTATTCTTTCTGAAACCAAGGCTGCTCTAGTGAGCACCATGAGCCTTTGGAAACAACAGATGTATACAATAGCAAAGTTTCATTTCTTT
ACCTTGAAACGTGAAAGTAAATCAGTGAGATCAGTGTTGCTTCTGCTTTTAATTTTTTTCACAGTTCAGATTTTTATGTTTTTGGTTCAT
CACTCTTTTAAAAATGCTGTGGTTCCCATCAAACTTGTTCCAGACTTATATTTTCTAAAACCTGGAGACAAACCACATAAATACAAAACA
AGTCTGCTTCTTCAAAATTCTGCTGCAGACTCAGATATCAGTGATCTTATTAGCTTTTTCACAAGCCAGAACATAATGGTGACGATGATT
AATGACAGTGACTATGTATCCGTGGCTCCCCATAGTGCGGCTTTAAATGTGATGCATTCAGAAAAGGACTATGTTTTTGCAGCTGTTTTC
AACAGTACTATGGTTTATTCTTTACCTATATTAGTGAATATCATTAGTAACTACTATCTTTATCATTTAAATGTGACTGAAACCATCCAG
ATCTGGAGTACCCCATTCTTTCAAGAAATTACTGATATAGTTTTTAAAATTGAGCTGTATTTTCAAGCAGCTTTGCTTGGAATCATTGTT
ACTGCAATGCCACCTTACTTTGCCATGGAAAATGCAGAGAATCATAAGATCAAAGCTTATACTCAACTTAAACTTTCAGGTCTTTTGCCA
TCTGCATATTGGATTGGACAAGCTGTTGTTGATATCCCCTTATTTTTTATCATTCTTATTTTGATGCTAGGAAGCTTATTGGCATTTCAT
TATGGATTATATTTTTATACTGTAAAGTTCCTTGCTGTGGTTTTTTGCCTTATTGGTTATGTTCCATCAGTTATTCTGTTCACTTATATT
GCTTCTTTCACCTTTAAGAAAATTTTAAATACCAAAGAATTTTGGTCATTTATCTATTCTGTGGCAGCGTTGGCTTGTATTGCAATCACT
GAAATAACTTTCTTTATGGGATACACAATTGCAACTATTCTTCATTATGCCTTTTGTATCATCATTCCAATCTATCCACTTCTAGGTTGC
CTGATTTCTTTCATAAAGATTTCTTGGAAGAATGTACGAAAAAATGTGGACACCTATAATCCATGGGATAGGCTTTCAGTAGCTGTTATA
TCGCCTTACCTGCAGTGTGTACTGTGGATTTTCCTCTTACAATACTATGAGAAAAAATATGGAGGCAGATCAATAAGAAAAGATCCCTTT
TTCAGAAACCTTTCAACGAAGTCTAAAAATAGGAAGCTTCCAGAACCACCAGACAATGAGGATGAAGATGAAGATGTCAAAGCTGAAAGA
CTAAAGGTCAAAGAGCTGATGGGTTGCCAGTGTTGTGAGGAGAAACCATCCATTATGGTCAGCAATTTGCATAAAGAATATGATGACAAG
AAAGATTTTCTTCTTTCAAGAAAAGTAAAGAAAGTGGCAACTAAATACATCTCTTTCTGTGTGAAAAAAGGAGAGATCTTAGGACTATTG
GGTCCAAATGGTGCTGGCAAAAGCACAATTATTAATATTCTGGTTGGTGATATTGAACCAACTTCAGGCCAGGTATTTTTAGGAGATTAT
TCTTCAGAGACAAGTGAAGATGATGATTCACTGAAGTGTATGGGTTACTGTCCTCAGATAAACCCTTTGTGGCCAGATACTACATTGCAG
GAACATTTTGAAATTTATGGAGCTGTCAAAGGAATGAGTGCAAGTGACATGAAAGAAGTCATAAGTCGAATAACACATGCACTTGATTTA
AAAGAACATCTTCAGAAGACTGTAAAGAAACTACCTGCAGGAATCAAACGAAAGTTGTGTTTTGCTCTAAGTATGCTAGGGAATCCTCAG
ATTACTTTGCTAGATGAACCATCTACAGGTATGGATCCCAAAGCCAAACAGCACATGTGGCGAGCAATTCGAACTGCATTTAAAAACAGA
AAGCGGGCTGCTATTCTGACCACTCACTATATGGAGGAGGCAGAGGCTGTCTGTGATCGAGTAGCTATCATGGTGTCTGGGCAGTTAAGA
TGTATCGGAACAGTACAACATCTAAAGAGTAAATTTGGAAAAGGCTACTTTTTGGAAATTAAATTGAAGGACTGGATAGAAAACCTAGAA
GTAGACCGCCTTCAAAGAGAAATTCAGTATATTTTCCCAAATGCAAGCCGTCAGGAAAGTTTTTCTTCTATTTTGGCTTATAAAATTCCT
AAGGAAGATGTTCAGTCCCTTTCACAATCTTTTTTTAAGCTGGAAGAAGCTAAACATGCTTTTGCCATTGAAGAATATAGCTTTTCTCAA
GCAACATTGGAACAGGTTTTTGTAGAACTCACTAAAGAACAAGAGGAGGAAGATAATAGTTGTGGAACTTTAAACAGCACACTTTGGTGG
GAACGAACACAAGAAGATAGAGTAGTATTTTGAATTTGTATTGTTCGGTCTGCTTACTGGGACTTCTTTCTTTTTCACTTAATTTTAACT
TTGGTTTAAAAAGTTTTTTATTGGAATGGTAACTGGAGAACCAAGAACGCACTTGAAATTTTTCTAAGCTCCTTAATTGAAATGCTGTGG
TTGTGTGTTTTGCTTTTCTTTAAATAAAACGTATGTATAATTAAGTGAAGCTGCATGTTTGTATTGAAGTATATTGAACTATATAGTTTG
TATGTCATCTTTTTCACCATTCAGAAACAGTGCTTCTGAATTTGTGATTTAAAGGAATTGTAATAGAATAGTTTTATTTTTAAGTTATCT
TTAAGTTTATGCCATCTTCTTAAATAAGTACGTAATGTTCCAATCTAAATAAAAAACTAATTCATAACTAATGCATAGAAAAGATACATA
AAGCAATGTGAAAGTTTCTTGCTTCTCCTTTTTAATTTCTAAAAAAGCCACTTTGAATGGAAGTTGTCATCCGTAAAAGCTGAAGTGTAA
GCACTAGGAAATCTCAATATAGAGATTTGAGGAAAGTTATATCCACTAGGTGGCAGTCATTGATCATAATAAGTGAAATGAGCCCTTGTT
CTAGTACATGATTTTAGGCTTAGGTAATTAGGTATGTGAAATTACATTTCTTTAATTTAAAGTAAAATTCAGAAGGTTTTAGTTATTATA
ATTAAAGGAAGACTGTGTGTAGAATCTTACGTAATAGTCTGATTCTTTGACTCTGTGGCTAGAATGACAGTTATCTATGGAGGTGGTAGA
ATTAAGCCATACCTTTTCCTTCATCACTCTTGGAACATATAAATTTTTTGTCATCTTCCTTGCAAAGGGCACATTTAATTTTGTTCTTGA
ATAAAATATTTTATTGGGTATTTGTTTTTATTGGTAAACTTTAGTGAATCTCTTCTATAAAATTGTAAGTAGATCAGTGTGTAGATTTAT
TTAGTAACTTACCTCATTGACTTTGGAACATGGTAGGATATGAATAAACTCTTTCAAGGGTTAAATTAAGAATTGTAAGTGCAGTGCGCC
TATTTCTTTTTAATAAGAACCAGAATTTCATTTTTGATAGAGTTAAAGGCATGGCTAATATTTTCTTAGAAATACTTCCTTGTACAACCC
ATGTATTGGCTCAAGGTATAAAATAGTGTAAATAATGCTAGTTGACATTACATTTCAACCAAATGAAAGTATTAACTTCATAAAACAAAT
ATATTGAGAGTGTGATTATTGTATTAGACAACAACAACAGCAATGACAGAAGGATTTGGTACTGAATTACTTTAAATAAGCAAAACCTTT
CAGTGGCATTATTCATTCTTTAATGTAGGCAAAATTTAATGAACTTTTAGCTTTATTGTGTAATAAGACATCTGTGATTTTAGGCTCTAG
CAGTGGATTTAAAAGTGTTCTTTCTCGGTACAAAGTACGTGGCTGATATTTTCCCCCATTGCTGGGGGCAGTTGCTATACACTTTCCTAA
AGTATATATAATGTTCACATAAATACCCAGGGACCTCTTTTTTGGGATGTGCTTTTGTAATTATGTGTAACCTTGAATACTTAAGTTTAG
TAAAAGCAACAAAATTATATCTATAGTTTACTAAGGCAGTCACGAAAAAGCATAGTTTTTTTTAGAACCTGACCATCCTAAGAAAGTTAT
GTCATCTGAAGATAGAGCATGACTAATGAAGAAAATTACCTGCTTTTGCACGTAGATTTGGTAACTTTCACTTTACATTTGTGAATGTGT
AATTGGTGCAAAGTAAATTTTTTTTCCTGCAAAGTGAAAGTTGAGTAGTCACAATCATGTTATTTATTTTGTTCATTTAGTTACTTTGCT
TTTAATGTATATGAATACATGCTCTTGTAAACAATTTTAAAAGACATTCAAATTTTTTTTTAGTTTTTATATACTCAGAATATATTTTGG
TTGTTAAATTAAATTATGTTCCCTTTTTCACAGTAACAAAATCTGACTCAGGAGAAATATAACTTAATTCTTAGGAAAACAAGGGTAAGT
GAGCTGGAAAGCAAAGGAGGCAAAAAGTGAAATATATTTATTTACAGTGTACAGTTCATGTTTATGAACATACTAATTTTAAAATGTCTT
AAATTACTGATCTCAAAACTTTTTTCTATGTCAGTACAGATAAATAAATAAATATACATATTAGGCAAAAGCAACATCACCAACCTTATA
TTTCCCATTCATGGTCAAATTTTCAAAGGAAAGTAAAAGCTGAGCTTTACTGAGTGAGTGTTTACTGACTAATAAGGCAAGAAAAAACAT
GATGAGTGTACTTTACATCTTACTTTTGTGGGCTCTTAATTTTTTTCTCTAGTTTGTTTTCAGTAAAGACAGTGGGTTTTCTTTAAAATA
ATTTTTTTCTTTTAAATTTGCACAAATTATCTTAGGTCAGTATTTTGGTTTTAATCATTAAAACATTTTTAGAGTAATGTAATTTAACAA
ATATTTTAAGTGATTATGTTTCCAGAAATGGATTCTTTGGAGAGAACTCGGATGACTATCAGTTTTGGCCCTGTAAGATCGTGGAGATCT
GTAAGATAGATACTTATATAACTTACATAAAATATATATAATATATTACTTATATAACTTATATAACTAGCTATTATTTTATATAACTAA
CTATAATATGACAAATCCTTTGCTAGTAGTACTAACAACGTTTTATAGGAGCACAATTAATTTTACTTAGGATAAGTGTTGTTATTATTG
TTTTTATTGTTGTTCTGTTAGTTACTCAAAACTTCATTCTAATTGTGCCCTGAGTTTGTTAAAATACCATACTGTATTTTTGTGTAACAT
GTAAATAGGCATTAATTTTTGAGAAATAGAAATGTTTATCCTTAATGTATTTTTAATTTGCTAACATTGATTTTTTATTTTCTTTCCTGA
AATAGCTTATTTCCTAAAATGAAAGAATTTATTCTCAGATGAATAATTTTTATATCAGCTATTCTTATCAGGTAAAAGTTTAATTATTTT

>In-frame_ENST00000335255_ENST00000392677_TCGA-D8-A27N-01A_FOXK2_chr17_80542064_+_ABCA5_chr17_67273983_length(amino acids)=1293AA_start in transcript=111_stop in transcript=3992
MGLGPRHRRPRGAARGPSRRPMAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSM
GHSSFISRRHLEIFTPPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSS
EKREKQEASESPVKAVQPHISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQPENEKEASG
GDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASE
SKLIEQAFRKRRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEARFAQSAPDYS
VFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAV
VPIKLVPDLYFLKPGDKPHKYKTSLLLQNSAADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYS
LPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQ
AVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMG
YTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTK
SKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGK
STIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKT
VKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQH
LKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVF

--------------------------------------------------------------
>In-frame_ENST00000335255_ENST00000588877_TCGA-D8-A27N-01A_FOXK2_chr17_80542064_+_ABCA5_chr17_67273983_length(transcript)=4576nt_BP=1453nt
CGGCCGCGCGTGCTCCCGCCCCTCGCCGCCGCTCGCTCGCTCGCCGGCCGGCGGCCTCCGCTCGGCCCCCTCCCTCAGCTCCGGTGCGCG
GCGGCCGACGACCCGCGCGGCCTGGGCCTCGGCCCGCGCCACCGGCGCCCGCGCGGAGCGGCCCGGGGGCCCTCACGCAGGCCCATGGCG
GCGGCCGCGGCGGCGCTCTCGGGCGCGGGCACGCCACCCGCGGGCGGCGGGGCCGGGGGCGGCGGGGCCGGGGGCGGCGGGTCCCCGCCG
GGCGGCTGGGCCGTGGCGCGCCTGGAGGGCCGCGAGTTCGAGTATCTGATGAAGAAGCGCTCGGTGACCATCGGCCGCAACTCGTCGCAG
GGCTCGGTGGACGTGAGCATGGGCCACTCGAGCTTCATCTCCCGGCGCCACCTCGAGATCTTCACGCCCCCGGGCGGCGGCGGCCATGGC
GGGGCCGCTCCGGAGCTGCCGCCCGCGCAGCCCAGGCCCGACGCCGGCGGCGACTTCTACCTGCGCTGCTTGGGCAAGAACGGGGTATTC
GTGGACGGCGTGTTCCAGAGGCGCGGGGCGCCGCCGCTGCAGCTGCCGCGCGTGTGCACATTCAGGTTCCCGAGCACAAACATCAAGATA
ACGTTCACTGCCCTGTCCAGCGAGAAGAGAGAGAAGCAGGAGGCGTCTGAGTCTCCAGTGAAGGCCGTACAGCCACACATCTCGCCCCTG
ACCATCAACATTCCAGACACCATGGCCCACCTCATCAGCCCTCTGCCCTCCCCCACGGGAACCATCAGCGCTGCAAACTCCTGCCCCTCC
AGCCCCCGGGGAGCGGGGTCTTCAGGGTACAAGGTGGGCCGAGTGATGCCATCTGACCTCAATTTAATGGCTGACAACTCACAGCCTGAA
AATGAAAAGGAAGCTTCAGGTGGAGACAGCCCGAAGGATGATTCAAAGCCGCCTTACTCCTACGCGCAGCTGATAGTTCAGGCGATTACG
ATGGCTCCCGACAAACAGCTCACCCTGAACGGGATTTATACACACATCACTAAAAATTATCCCTACTACAGGACTGCGGACAAGGGCTGG
CAGAATTCAATTCGCCACAATCTCTCTCTGAATCGTTATTTCATCAAAGTGCCGCGTTCCCAGGAAGAACCAGGCAAAGGCTCGTTCTGG
AGGATAGACCCAGCCTCTGAAAGCAAATTAATAGAACAGGCTTTTAGGAAACGACGGCCTAGGGGCGTGCCCTGCTTTAGAACCCCTCTG
GGACCGCTCTCTTCTAGGAGTGCCCCAGCCTCTCCCAATCACGCGGGAGTGCTGTCTGCTCACTCTAGTGGCGCCCAGACCCCTGAGAGC
CTGTCGAGGGAAGGTTCGCCGGCCCCCCTGGAGCCTGAGCCTGGCGCTGCACAGCCCAAACTCGCTGTCATCCAGGAAGCCCGGTTTGCC
CAGAGCGCCCCAGATTATAGTGTATTTACTCAGCAGCCACTGGAGGAAGAAATGGATTCAAAATCTTTTGATGAAATGGAACAGAGCTTA
CTTATTCTTTCTGAAACCAAGGCTGCTCTAGTGAGCACCATGAGCCTTTGGAAACAACAGATGTATACAATAGCAAAGTTTCATTTCTTT
ACCTTGAAACGTGAAAGTAAATCAGTGAGATCAGTGTTGCTTCTGCTTTTAATTTTTTTCACAGTTCAGATTTTTATGTTTTTGGTTCAT
CACTCTTTTAAAAATGCTGTGGTTCCCATCAAACTTGTTCCAGACTTATATTTTCTAAAACCTGGAGACAAACCACATAAATACAAAACA
AGTCTGCTTCTTCAAAATTCTGCTGACTCAGATATCAGTGATCTTATTAGCTTTTTCACAAGCCAGAACATAATGGTGACGATGATTAAT
GACAGTGACTATGTATCCGTGGCTCCCCATAGTGCGGCTTTAAATGTGATGCATTCAGAAAAGGACTATGTTTTTGCAGCTGTTTTCAAC
AGTACTATGGTTTATTCTTTACCTATATTAGTGAATATCATTAGTAACTACTATCTTTATCATTTAAATGTGACTGAAACCATCCAGATC
TGGAGTACCCCATTCTTTCAAGAAATTACTGATATAGTTTTTAAAATTGAGCTGTATTTTCAAGCAGCTTTGCTTGGAATCATTGTTACT
GCAATGCCACCTTACTTTGCCATGGAAAATGCAGAGAATCATAAGATCAAAGCTTATACTCAACTTAAACTTTCAGGTCTTTTGCCATCT
GCATATTGGATTGGACAAGCTGTTGTTGATATCCCCTTATTTTTTATCATTCTTATTTTGATGCTAGGAAGCTTATTGGCATTTCATTAT
GGATTATATTTTTATACTGTAAAGTTCCTTGCTGTGGTTTTTTGCCTTATTGGTTATGTTCCATCAGTTATTCTGTTCACTTATATTGCT
TCTTTCACCTTTAAGAAAATTTTAAATACCAAAGAATTTTGGTCATTTATCTATTCTGTGGCAGCGTTGGCTTGTATTGCAATCACTGAA
ATAACTTTCTTTATGGGATACACAATTGCAACTATTCTTCATTATGCCTTTTGTATCATCATTCCAATCTATCCACTTCTAGGTTGCCTG
ATTTCTTTCATAAAGATTTCTTGGAAGAATGTACGAAAAAATGTGGACACCTATAATCCATGGGATAGGCTTTCAGTAGCTGTTATATCG
CCTTACCTGCAGTGTGTACTGTGGATTTTCCTCTTACAATACTATGAGAAAAAATATGGAGGCAGATCAATAAGAAAAGATCCCTTTTTC
AGAAACCTTTCAACGAAGTCTAAAAATAGGAAGCTTCCAGAACCACCAGACAATGAGGATGAAGATGAAGATGTCAAAGCTGAAAGACTA
AAGGTCAAAGAGCTGATGGGTTGCCAGTGTTGTGAGGAGAAACCATCCATTATGGTCAGCAATTTGCATAAAGAATATGATGACAAGAAA
GATTTTCTTCTTTCAAGAAAAGTAAAGAAAGTGGCAACTAAATACATCTCTTTCTGTGTGAAAAAAGGAGAGATCTTAGGACTATTGGGT
CCAAATGGTGCTGGCAAAAGCACAATTATTAATATTCTGGTTGGTGATATTGAACCAACTTCAGGCCAGGTATTTTTAGGAGATTATTCT
TCAGAGACAAGTGAAGATGATGATTCACTGAAGTGTATGGGTTACTGTCCTCAGATAAACCCTTTGTGGCCAGATACTACATTGCAGGAA
CATTTTGAAATTTATGGAGCTGTCAAAGGAATGAGTGCAAGTGACATGAAAGAAGTCATAAGTCGAATAACACATGCACTTGATTTAAAA
GAACATCTTCAGAAGACTGTAAAGAAACTACCTGCAGGAATCAAACGAAAGTTGTGTTTTGCTCTAAGTATGCTAGGGAATCCTCAGATT
ACTTTGCTAGATGAACCATCTACAGGTATGGATCCCAAAGCCAAACAGCACATGTGGCGAGCAATTCGAACTGCATTTAAAAACAGAAAG
CGGGCTGCTATTCTGACCACTCACTATATGGAGGAGGCAGAGGCTGTCTGTGATCGAGTAGCTATCATGGTGTCTGGGCAGTTAAGATGT
ATCGGAACAGTACAACATCTAAAGAGTAAATTTGGAAAAGGCTACTTTTTGGAAATTAAATTGAAGGACTGGATAGAAAACCTAGAAGTA
GACCGCCTTCAAAGAGAAATTCAGTATATTTTCCCAAATGCAAGCCGTCAGGAAAGTTTTTCTTCTATTTTGGCTTATAAAATTCCTAAG
GAAGATGTTCAGTCCCTTTCACAATCTTTTTTTAAGCTGGAAGAAGCTAAACATGCTTTTGCCATTGAAGAATATAGCTTTTCTCAAGCA
ACATTGGAACAGGTTTTTGTAGAACTCACTAAAGAACAAGAGGAGGAAGATAATAGTTGTGGAACTTTAAACAGCACACTTTGGTGGGAA
CGAACACAAGAAGATAGAGTAGTATTTTGAATTTGTATTGTTCGGTCTGCTTACTGGGACTTCTTTCTTTTTCACTTAATTTTAACTTTG
GTTTAAAAAGTTTTTTATTGGAATGGTAACTGGAGAACCAAGAACGCACTTGAAATTTTTCTAAGCTCCTTAATTGAAATGCTGTGGTTG
TGTGTTTTGCTTTTCTTTAAATAAAACGTATGTATAATTAAGTGAAGCTGCATGTTTGTATTGAAGTATATTGAACTATATAGTTTGTAT
GTCATCTTTTTCACCATTCAGAAACAGTGCTTCTGAATTTGTGATTTAAAGGAATTGTAATAGAATAGTTTTATTTTTAAGTTATCTTTA
AGTTTATGCCATCTTCTTAAATAAGTACGTAATGTTCCAATCTAAATAAAAAACTAATTCATAACTAATGCATAGAAAAGATACATAAAG
CAATGTGAAAGTTTCTTGCTTCTCCTTTTTAATTTCTAAAAAAGCCACTTTGAATGGAAGTTGTCATCCGTAAAAGCTGAAGTGTAAGCA

>In-frame_ENST00000335255_ENST00000588877_TCGA-D8-A27N-01A_FOXK2_chr17_80542064_+_ABCA5_chr17_67273983_length(amino acids)=1292AA_start in transcript=111_stop in transcript=3989
MGLGPRHRRPRGAARGPSRRPMAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNSSQGSVDVSM
GHSSFISRRHLEIFTPPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSS
EKREKQEASESPVKAVQPHISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQPENEKEASG
GDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASE
SKLIEQAFRKRRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEARFAQSAPDYS
VFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAV
VPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSL
PILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQA
VVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGY
TIATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKS
KNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKS
TIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTV
KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHL
KSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFV

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Fusion Gene PPI Analysis for FOXK2-ABCA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOXK2-ABCA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FOXK2-ABCA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABCA5C0009402Colorectal Carcinoma1CTD_human
TgeneABCA5C0009404Colorectal Neoplasms1CTD_human
TgeneABCA5C1851120Hypertrichosis Terminalis, Generalized, with or without Gingival Hyperplasia1CTD_human;ORPHANET