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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FOXO3-ARMC2 (FusionGDB2 ID:31071)

Fusion Gene Summary for FOXO3-ARMC2

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXO3-ARMC2
Fusion gene ID: 31071
HgeneTgene
Gene symbol

FOXO3

ARMC2

Gene ID

2309

84071

Gene nameforkhead box O3armadillo repeat containing 2
SynonymsAF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3ASPGF38|bA787I22.1
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein O3forkhead box O3Aforkhead homolog (rhabdomyosarcoma) like 1forkhead in rhabdomyosarcoma-like 1forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1armadillo repeat-containing protein 2
Modification date2020032920200313
UniProtAcc

O43524

Q8NEN0

Ensembl transtripts involved in fusion geneENST00000343882, ENST00000406360, 
ENST00000540898, 		ENST00000368972, 
ENST00000392644, ENST00000481850, 
Fusion gene scores* DoF score9 X 5 X 7=31515 X 15 X 7=1575
# samples 1216
** MAII scorelog2(12/315*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1575*10)=-3.29920801838728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOXO3 [Title/Abstract] AND ARMC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFOXO3(108883032)-ARMC2(109215669), # samples:1
FOXO3(108883032)-ARMC2(109274236), # samples:1
FOXO3(108883032)-ARMC2(109215670), # samples:1
FOXO3(108883032)-ARMC2(109220897), # samples:1
FOXO3(108883029)-ARMC2(109215667), # samples:1
Anticipated loss of major functional domain due to fusion event.FOXO3-ARMC2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
FOXO3-ARMC2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FOXO3-ARMC2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
FOXO3-ARMC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXO3

GO:0000122

negative regulation of transcription by RNA polymerase II

20371612

HgeneFOXO3

GO:0006417

regulation of translation

21329882

HgeneFOXO3

GO:0043065

positive regulation of apoptotic process

20371612

HgeneFOXO3

GO:0045648

positive regulation of erythrocyte differentiation

14734530

HgeneFOXO3

GO:0045893

positive regulation of transcription, DNA-templated

10102273|15084260

HgeneFOXO3

GO:0045944

positive regulation of transcription by RNA polymerase II

10102273|14734530


check buttonFusion gene breakpoints across FOXO3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ARMC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UVMTCGA-VD-A8KJFOXO3chr6

108883032

+ARMC2chr6

109215669

+
ChimerDB4GBMTCGA-32-1970-01AFOXO3chr6

108883032

+ARMC2chr6

109274236

+
ChimerDB4UVMTCGA-VD-A8KJFOXO3chr6

108883032

+ARMC2chr6

109215670

+
ChimerDB4UVMTCGA-VD-A8KJFOXO3chr6

108883032

+ARMC2chr6

109220897

+
ChimerDB4UVMTCGA-VD-A8KJ-01AFOXO3chr6

108883029

+ARMC2chr6

109215667

+


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Fusion Gene ORF analysis for FOXO3-ARMC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000343882ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109215669

+
Frame-shiftENST00000343882ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109215669

+
5CDS-intronENST00000343882ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109215669

+
Frame-shiftENST00000406360ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109215669

+
Frame-shiftENST00000406360ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109215669

+
5CDS-intronENST00000406360ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109215669

+
intron-3CDSENST00000540898ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109215669

+
intron-3CDSENST00000540898ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109215669

+
intron-intronENST00000540898ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109215669

+
In-frameENST00000343882ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109274236

+
In-frameENST00000343882ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109274236

+
5CDS-intronENST00000343882ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109274236

+
In-frameENST00000406360ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109274236

+
In-frameENST00000406360ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109274236

+
5CDS-intronENST00000406360ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109274236

+
intron-3CDSENST00000540898ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109274236

+
intron-3CDSENST00000540898ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109274236

+
intron-intronENST00000540898ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109274236

+
Frame-shiftENST00000343882ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109215670

+
Frame-shiftENST00000343882ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109215670

+
5CDS-intronENST00000343882ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109215670

+
Frame-shiftENST00000406360ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109215670

+
Frame-shiftENST00000406360ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109215670

+
5CDS-intronENST00000406360ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109215670

+
intron-3CDSENST00000540898ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109215670

+
intron-3CDSENST00000540898ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109215670

+
intron-intronENST00000540898ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109215670

+
Frame-shiftENST00000343882ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109220897

+
Frame-shiftENST00000343882ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109220897

+
5CDS-intronENST00000343882ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109220897

+
Frame-shiftENST00000406360ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109220897

+
Frame-shiftENST00000406360ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109220897

+
5CDS-intronENST00000406360ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109220897

+
intron-3CDSENST00000540898ENST00000368972FOXO3chr6

108883032

+ARMC2chr6

109220897

+
intron-3CDSENST00000540898ENST00000392644FOXO3chr6

108883032

+ARMC2chr6

109220897

+
intron-intronENST00000540898ENST00000481850FOXO3chr6

108883032

+ARMC2chr6

109220897

+
Frame-shiftENST00000343882ENST00000368972FOXO3chr6

108883029

+ARMC2chr6

109215667

+
Frame-shiftENST00000343882ENST00000392644FOXO3chr6

108883029

+ARMC2chr6

109215667

+
5CDS-intronENST00000343882ENST00000481850FOXO3chr6

108883029

+ARMC2chr6

109215667

+
Frame-shiftENST00000406360ENST00000368972FOXO3chr6

108883029

+ARMC2chr6

109215667

+
Frame-shiftENST00000406360ENST00000392644FOXO3chr6

108883029

+ARMC2chr6

109215667

+
5CDS-intronENST00000406360ENST00000481850FOXO3chr6

108883029

+ARMC2chr6

109215667

+
intron-3CDSENST00000540898ENST00000368972FOXO3chr6

108883029

+ARMC2chr6

109215667

+
intron-3CDSENST00000540898ENST00000392644FOXO3chr6

108883029

+ARMC2chr6

109215667

+
intron-intronENST00000540898ENST00000481850FOXO3chr6

108883029

+ARMC2chr6

109215667

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343882FOXO3chr6108883032+ENST00000368972ARMC2chr6109274236+22019252381932564
ENST00000343882FOXO3chr6108883032+ENST00000392644ARMC2chr6109274236+24029252381932564
ENST00000406360FOXO3chr6108883032+ENST00000368972ARMC2chr6109274236+22409642051971588
ENST00000406360FOXO3chr6108883032+ENST00000392644ARMC2chr6109274236+24419642051971588

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343882ENST00000368972FOXO3chr6108883032+ARMC2chr6109274236+0.0045564650.9954436
ENST00000343882ENST00000392644FOXO3chr6108883032+ARMC2chr6109274236+0.0026817050.9973183
ENST00000406360ENST00000368972FOXO3chr6108883032+ARMC2chr6109274236+0.0039681390.9960318
ENST00000406360ENST00000392644FOXO3chr6108883032+ARMC2chr6109274236+0.0022146540.99778533

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Fusion Genomic Features for FOXO3-ARMC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FOXO3chr6108883032+ARMC2chr6109215669+3.68E-050.99996316
FOXO3chr6108883032+ARMC2chr6109215669+3.68E-050.99996316
FOXO3chr6108883032+ARMC2chr6109220896+4.15E-070.99999964
FOXO3chr6108883032+ARMC2chr6109274235+7.68E-080.9999999
FOXO3chr6108883032+ARMC2chr6109215669+3.68E-050.99996316
FOXO3chr6108883032+ARMC2chr6109215669+3.68E-050.99996316
FOXO3chr6108883032+ARMC2chr6109220896+4.15E-070.99999964
FOXO3chr6108883032+ARMC2chr6109274235+7.68E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FOXO3-ARMC2


check button Go to

FGviewer for the breakpoints of chr6:108883032-chr6:109274236

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXO3

O43524

ARMC2

Q8NEN0

FUNCTION: Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). {ECO:0000250|UniProtKB:Q9WVH4, ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:23283301}.FUNCTION: Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity). {ECO:0000250|UniProtKB:Q3URY6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118551_589532.0868.0RepeatNote=ARM 7
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118591_616532.0868.0RepeatNote=ARM 8
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118619_662532.0868.0RepeatNote=ARM 9
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118664_705532.0868.0RepeatNote=ARM 10
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118707_746532.0868.0RepeatNote=ARM 11
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118748_790532.0868.0RepeatNote=ARM 12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFOXO3chr6:108883032chr6:109274236ENST00000343882+24157_251207.02263.0DNA bindingFork-head
HgeneFOXO3chr6:108883032chr6:109274236ENST00000406360+13157_251207.02000.0DNA bindingFork-head
HgeneFOXO3chr6:108883032chr6:109274236ENST00000343882+24242_259207.02263.0MotifNuclear localization signal
HgeneFOXO3chr6:108883032chr6:109274236ENST00000406360+13242_259207.02000.0MotifNuclear localization signal
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118262_301532.0868.0RepeatNote=ARM 1
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118304_344532.0868.0RepeatNote=ARM 2
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118363_403532.0868.0RepeatNote=ARM 3
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118408_449532.0868.0RepeatNote=ARM 4
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118462_503532.0868.0RepeatNote=ARM 5
TgeneARMC2chr6:108883032chr6:109274236ENST000003926441118506_547532.0868.0RepeatNote=ARM 6


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Fusion Gene Sequence for FOXO3-ARMC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000343882_ENST00000368972_TCGA-32-1970-01A_FOXO3_chr6_108883032_+_ARMC2_chr6_109274236_length(transcript)=2201nt_BP=925nt
GGGAGGAGGAGGAATGTGGAAGGTGGCGGCGCGCGAGCTGACAGGCGGTTCCTCGGGCGGGCTGCGGCGACGGCCCGAGCGCTTCTCCTT
CGCCGAGGTTGCGCGCCCCCTCCTCGCCGTGCCCCGGGCCCGCGCGGGATCGTGCGTCGTCCCGCCGCGTCCCTGAAGGGAAGGAAGCGA
GGCGGCGGCGGCGGCGCCCGGGAGCCGGAGCCTTCGCGGCGTCCACGTCCCTCCCCCGCTGCACCCCGCCCCGGCGCGAGAGGAGAGCGC
GAGAGCCCCAGCCGCGGGCGGGCGGGCGGCGAAGATGGCAGAGGCACCGGCTTCCCCGGCCCCGCTCTCTCCGCTCGAAGTGGAGCTGGA
CCCGGAGTTCGAGCCCCAGAGCCGTCCGCGATCCTGTACGTGGCCCCTGCAAAGGCCGGAGCTCCAAGCGAGCCCTGCCAAGCCCTCGGG
GGAGACGGCCGCCGACTCCATGATCCCCGAGGAGGAGGACGATGAAGACGACGAGGACGGCGGGGGACGGGCCGGCTCGGCCATGGCGAT
CGGCGGCGGCGGCGGGAGCGGCACGCTGGGCTCCGGGCTGCTCCTTGAGGACTCGGCCCGGGTGCTGGCACCCGGAGGGCAAGACCCCGG
GTCTGGGCCAGCCACCGCGGCGGGCGGGCTGAGCGGGGGTACACAGGCGCTGCTGCAGCCTCAGCAACCGCTGCCACCGCCGCAGCCGGG
GGCGGCTGGGGGCTCCGGGCAGCCGAGGAAATGTTCGTCGCGGCGGAACGCCTGGGGAAACCTGTCCTACGCGGACCTGATCACCCGCGC
CATCGAGAGCTCCCCGGACAAACGGCTCACTCTGTCCCAGATCTACGAGTGGATGGTGCGTTGCGTGCCCTACTTCAAGGATAAGGGCGA
CAGCAACAGCTCTGCCGGCTGGAAGGATTTAGTCGTCCGTGTTGTTTTTATTCTTGGCAACCTGACGGCAAAAAATAACCAGGCTCGTGA
ACAATTTTCCAAAGAGAAAGGGAGCATCCAAACTCTGCTGTCATTATTCCAGACGTTCCATCAGCTGGATCTGCATTCCCAGAAGCCGGT
GGGCCAACGAGGCGAGCAGCACAGGGCGCAGAGGCCGCCGTCAGAGGCAGAGGACGTGCTCATCAAGCTGACTCGTGTGCTGGCCAACAT
TGCCATCCACCCGGGCGTGGGCCCGGTGCTGGCCGCCAACCCGGGGATAGTGGGCCTGCTCCTGACCACGCTGGAATACAAGTCACTTGA
TGATTGTGAGGAGCTGGTGATCAATGCTACAGCGACAATCAACAATTTATCTTACTACCAAGTGAAGAATTCCATAATTCAAGACAAAAA
GCTATATATTGCTGAATTGCTCTTAAAGCTTCTTGTCAGTAACAACATGGATGGAATCCTGGAGGCTGTGCGTGTTTTCGGAAATCTCTC
CCAGGACCATGATGTCTGCGATTTCATTGTGCAGAACAATGTCCACAGGTTCATGATGGCGCTGCTGGATGCTCAGCATCAGGATATCTG
CTTTTCTGCCTGTGGTGTTCTCCTCAATCTCACTGTGGATAAAGACAAGCGTGTCATCTTGAAAGAAGGAGGTGGCATTAAAAAGTTAGT
GGACTGTTTAAGAGATTTGGGTCCTACTGATTGGCAGCTGGCCTGCTTGGTTTGTAAAACTTTATGGAACTTCAGTGAAAACATCACTAA
TGCTTCGTCATGTTTTGGAAATGAAGACACCAACACACTCTTACTCTTGCTCTCATCATTTTTAGATGAAGAACTAGCACTGGATGGCAG
TTTTGATCCAGACCTAAAAAACTATCACAAACTCCATTGGGAAACAGAATTCAAACCTGTGGCACAGCAGCTTCTAAACCGAATTCAGAG
ACATCACACCTTCCTGGAACCCCTGCCCATTCCCTCTTTCTAACATGATGCAGATTAACAGTAGAAACGAGAACTCACGTCTCCCTCATT
CTTAAGAACTGGTAACAAACGTGAACATTTTTTTCAGCATTAACAAATGTGGAAAGTTTTTCAAGAACTGGTTTTAGTGAGTAGCTGAAG
TATTTTTTAAAATTAAGCATTTCTTCTTGTTAGGTATTATGGAAAAATGAATATACACATTATATTTCCTGTTGAGAGAAATGTAAGATG

>In-frame_ENST00000343882_ENST00000368972_TCGA-32-1970-01A_FOXO3_chr6_108883032_+_ARMC2_chr6_109274236_length(amino acids)=564AA_start in transcript=238_stop in transcript=1932
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKDLVVRVVFILGNLTAKNNQAREQFSKEKGSIQTLLSLFQTF
HQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLEYKSLDDCEELVINATATINNLSYY
QVKNSIIQDKKLYIAELLLKLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQHQDICFSACGVLLNLTVDKDKRVI
LKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSFLDEELALDGSFDPDLKNYHKLHWETEFKP

--------------------------------------------------------------
>In-frame_ENST00000343882_ENST00000392644_TCGA-32-1970-01A_FOXO3_chr6_108883032_+_ARMC2_chr6_109274236_length(transcript)=2402nt_BP=925nt
GGGAGGAGGAGGAATGTGGAAGGTGGCGGCGCGCGAGCTGACAGGCGGTTCCTCGGGCGGGCTGCGGCGACGGCCCGAGCGCTTCTCCTT
CGCCGAGGTTGCGCGCCCCCTCCTCGCCGTGCCCCGGGCCCGCGCGGGATCGTGCGTCGTCCCGCCGCGTCCCTGAAGGGAAGGAAGCGA
GGCGGCGGCGGCGGCGCCCGGGAGCCGGAGCCTTCGCGGCGTCCACGTCCCTCCCCCGCTGCACCCCGCCCCGGCGCGAGAGGAGAGCGC
GAGAGCCCCAGCCGCGGGCGGGCGGGCGGCGAAGATGGCAGAGGCACCGGCTTCCCCGGCCCCGCTCTCTCCGCTCGAAGTGGAGCTGGA
CCCGGAGTTCGAGCCCCAGAGCCGTCCGCGATCCTGTACGTGGCCCCTGCAAAGGCCGGAGCTCCAAGCGAGCCCTGCCAAGCCCTCGGG
GGAGACGGCCGCCGACTCCATGATCCCCGAGGAGGAGGACGATGAAGACGACGAGGACGGCGGGGGACGGGCCGGCTCGGCCATGGCGAT
CGGCGGCGGCGGCGGGAGCGGCACGCTGGGCTCCGGGCTGCTCCTTGAGGACTCGGCCCGGGTGCTGGCACCCGGAGGGCAAGACCCCGG
GTCTGGGCCAGCCACCGCGGCGGGCGGGCTGAGCGGGGGTACACAGGCGCTGCTGCAGCCTCAGCAACCGCTGCCACCGCCGCAGCCGGG
GGCGGCTGGGGGCTCCGGGCAGCCGAGGAAATGTTCGTCGCGGCGGAACGCCTGGGGAAACCTGTCCTACGCGGACCTGATCACCCGCGC
CATCGAGAGCTCCCCGGACAAACGGCTCACTCTGTCCCAGATCTACGAGTGGATGGTGCGTTGCGTGCCCTACTTCAAGGATAAGGGCGA
CAGCAACAGCTCTGCCGGCTGGAAGGATTTAGTCGTCCGTGTTGTTTTTATTCTTGGCAACCTGACGGCAAAAAATAACCAGGCTCGTGA
ACAATTTTCCAAAGAGAAAGGGAGCATCCAAACTCTGCTGTCATTATTCCAGACGTTCCATCAGCTGGATCTGCATTCCCAGAAGCCGGT
GGGCCAACGAGGCGAGCAGCACAGGGCGCAGAGGCCGCCGTCAGAGGCAGAGGACGTGCTCATCAAGCTGACTCGTGTGCTGGCCAACAT
TGCCATCCACCCGGGCGTGGGCCCGGTGCTGGCCGCCAACCCGGGGATAGTGGGCCTGCTCCTGACCACGCTGGAATACAAGTCACTTGA
TGATTGTGAGGAGCTGGTGATCAATGCTACAGCGACAATCAACAATTTATCTTACTACCAAGTGAAGAATTCCATAATTCAAGACAAAAA
GCTATATATTGCTGAATTGCTCTTAAAGCTTCTTGTCAGTAACAACATGGATGGAATCCTGGAGGCTGTGCGTGTTTTCGGAAATCTCTC
CCAGGACCATGATGTCTGCGATTTCATTGTGCAGAACAATGTCCACAGGTTCATGATGGCGCTGCTGGATGCTCAGCATCAGGATATCTG
CTTTTCTGCCTGTGGTGTTCTCCTCAATCTCACTGTGGATAAAGACAAGCGTGTCATCTTGAAAGAAGGAGGTGGCATTAAAAAGTTAGT
GGACTGTTTAAGAGATTTGGGTCCTACTGATTGGCAGCTGGCCTGCTTGGTTTGTAAAACTTTATGGAACTTCAGTGAAAACATCACTAA
TGCTTCGTCATGTTTTGGAAATGAAGACACCAACACACTCTTACTCTTGCTCTCATCATTTTTAGATGAAGAACTAGCACTGGATGGCAG
TTTTGATCCAGACCTAAAAAACTATCACAAACTCCATTGGGAAACAGAATTCAAACCTGTGGCACAGCAGCTTCTAAACCGAATTCAGAG
ACATCACACCTTCCTGGAACCCCTGCCCATTCCCTCTTTCTAACATGATGCAGATTAACAGTAGAAACGAGAACTCACGTCTCCCTCATT
CTTAAGAACTGGTAACAAACGTGAACATTTTTTTCAGCATTAACAAATGTGGAAAGTTTTTCAAGAACTGGTTTTAGTGAGTAGCTGAAG
TATTTTTTAAAATTAAGCATTTCTTCTTGTTAGGTATTATGGAAAAATGAATATACACATTATATTTCCTGTTGAGAGAAATGTAAGATG
AAAATATGTGCATTTTCAAGTAAATGACTTTTTCTTCTATTCTCTATTAAACAATTTAGTTCTAGTCTTAAAATCTTGATTTAACAATTT
TGGAATTGAAGTGTTCATAAGTTAAATGAACTGTGCAATGAAGGCTGTTAGATTATATAGAAAGAAGGGTAGGCAACATGAGTGGAACAC

>In-frame_ENST00000343882_ENST00000392644_TCGA-32-1970-01A_FOXO3_chr6_108883032_+_ARMC2_chr6_109274236_length(amino acids)=564AA_start in transcript=238_stop in transcript=1932
MHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEEEDDEDDED
GGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWG
NLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKDLVVRVVFILGNLTAKNNQAREQFSKEKGSIQTLLSLFQTF
HQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLEYKSLDDCEELVINATATINNLSYY
QVKNSIIQDKKLYIAELLLKLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQHQDICFSACGVLLNLTVDKDKRVI
LKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSFLDEELALDGSFDPDLKNYHKLHWETEFKP

--------------------------------------------------------------
>In-frame_ENST00000406360_ENST00000368972_TCGA-32-1970-01A_FOXO3_chr6_108883032_+_ARMC2_chr6_109274236_length(transcript)=2240nt_BP=964nt
GCGCGAGGCCGTCGATTCGCTCGCGGCTCCATCGCGGCCTGGCCGGGGGGCGGTGTCTGCTGCGCCAGGTTCGCTGGCCGCACGTCTTCA
GGTCCTCCTGTTCCTGGGAGGCGGGCGCGGCAGGACTGGGAGGTGGCGGCAGCGGGCGAGGACTCGCCGAGGACGGGGCTCCGGCCCGGG
ATAACCAACTCTCCTTCTCTCTTCTTTGGTGCTTCCCCAGGCGGCGGCGGCGGCGCCCGGGAGCCGGAGCCTTCGCGGCGTCCACGTCCC
TCCCCCGCTGCACCCCGCCCCGGCGCGAGAGGAGAGCGCGAGAGCCCCAGCCGCGGGCGGGCGGGCGGCGAAGATGGCAGAGGCACCGGC
TTCCCCGGCCCCGCTCTCTCCGCTCGAAGTGGAGCTGGACCCGGAGTTCGAGCCCCAGAGCCGTCCGCGATCCTGTACGTGGCCCCTGCA
AAGGCCGGAGCTCCAAGCGAGCCCTGCCAAGCCCTCGGGGGAGACGGCCGCCGACTCCATGATCCCCGAGGAGGAGGACGATGAAGACGA
CGAGGACGGCGGGGGACGGGCCGGCTCGGCCATGGCGATCGGCGGCGGCGGCGGGAGCGGCACGCTGGGCTCCGGGCTGCTCCTTGAGGA
CTCGGCCCGGGTGCTGGCACCCGGAGGGCAAGACCCCGGGTCTGGGCCAGCCACCGCGGCGGGCGGGCTGAGCGGGGGTACACAGGCGCT
GCTGCAGCCTCAGCAACCGCTGCCACCGCCGCAGCCGGGGGCGGCTGGGGGCTCCGGGCAGCCGAGGAAATGTTCGTCGCGGCGGAACGC
CTGGGGAAACCTGTCCTACGCGGACCTGATCACCCGCGCCATCGAGAGCTCCCCGGACAAACGGCTCACTCTGTCCCAGATCTACGAGTG
GATGGTGCGTTGCGTGCCCTACTTCAAGGATAAGGGCGACAGCAACAGCTCTGCCGGCTGGAAGGATTTAGTCGTCCGTGTTGTTTTTAT
TCTTGGCAACCTGACGGCAAAAAATAACCAGGCTCGTGAACAATTTTCCAAAGAGAAAGGGAGCATCCAAACTCTGCTGTCATTATTCCA
GACGTTCCATCAGCTGGATCTGCATTCCCAGAAGCCGGTGGGCCAACGAGGCGAGCAGCACAGGGCGCAGAGGCCGCCGTCAGAGGCAGA
GGACGTGCTCATCAAGCTGACTCGTGTGCTGGCCAACATTGCCATCCACCCGGGCGTGGGCCCGGTGCTGGCCGCCAACCCGGGGATAGT
GGGCCTGCTCCTGACCACGCTGGAATACAAGTCACTTGATGATTGTGAGGAGCTGGTGATCAATGCTACAGCGACAATCAACAATTTATC
TTACTACCAAGTGAAGAATTCCATAATTCAAGACAAAAAGCTATATATTGCTGAATTGCTCTTAAAGCTTCTTGTCAGTAACAACATGGA
TGGAATCCTGGAGGCTGTGCGTGTTTTCGGAAATCTCTCCCAGGACCATGATGTCTGCGATTTCATTGTGCAGAACAATGTCCACAGGTT
CATGATGGCGCTGCTGGATGCTCAGCATCAGGATATCTGCTTTTCTGCCTGTGGTGTTCTCCTCAATCTCACTGTGGATAAAGACAAGCG
TGTCATCTTGAAAGAAGGAGGTGGCATTAAAAAGTTAGTGGACTGTTTAAGAGATTTGGGTCCTACTGATTGGCAGCTGGCCTGCTTGGT
TTGTAAAACTTTATGGAACTTCAGTGAAAACATCACTAATGCTTCGTCATGTTTTGGAAATGAAGACACCAACACACTCTTACTCTTGCT
CTCATCATTTTTAGATGAAGAACTAGCACTGGATGGCAGTTTTGATCCAGACCTAAAAAACTATCACAAACTCCATTGGGAAACAGAATT
CAAACCTGTGGCACAGCAGCTTCTAAACCGAATTCAGAGACATCACACCTTCCTGGAACCCCTGCCCATTCCCTCTTTCTAACATGATGC
AGATTAACAGTAGAAACGAGAACTCACGTCTCCCTCATTCTTAAGAACTGGTAACAAACGTGAACATTTTTTTCAGCATTAACAAATGTG
GAAAGTTTTTCAAGAACTGGTTTTAGTGAGTAGCTGAAGTATTTTTTAAAATTAAGCATTTCTTCTTGTTAGGTATTATGGAAAAATGAA

>In-frame_ENST00000406360_ENST00000368972_TCGA-32-1970-01A_FOXO3_chr6_108883032_+_ARMC2_chr6_109274236_length(amino acids)=588AA_start in transcript=205_stop in transcript=1971
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKDLVVRVVFILGNLTAKN
NQAREQFSKEKGSIQTLLSLFQTFHQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLE
YKSLDDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLLKLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQ
HQDICFSACGVLLNLTVDKDKRVILKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSFLDEEL

--------------------------------------------------------------
>In-frame_ENST00000406360_ENST00000392644_TCGA-32-1970-01A_FOXO3_chr6_108883032_+_ARMC2_chr6_109274236_length(transcript)=2441nt_BP=964nt
GCGCGAGGCCGTCGATTCGCTCGCGGCTCCATCGCGGCCTGGCCGGGGGGCGGTGTCTGCTGCGCCAGGTTCGCTGGCCGCACGTCTTCA
GGTCCTCCTGTTCCTGGGAGGCGGGCGCGGCAGGACTGGGAGGTGGCGGCAGCGGGCGAGGACTCGCCGAGGACGGGGCTCCGGCCCGGG
ATAACCAACTCTCCTTCTCTCTTCTTTGGTGCTTCCCCAGGCGGCGGCGGCGGCGCCCGGGAGCCGGAGCCTTCGCGGCGTCCACGTCCC
TCCCCCGCTGCACCCCGCCCCGGCGCGAGAGGAGAGCGCGAGAGCCCCAGCCGCGGGCGGGCGGGCGGCGAAGATGGCAGAGGCACCGGC
TTCCCCGGCCCCGCTCTCTCCGCTCGAAGTGGAGCTGGACCCGGAGTTCGAGCCCCAGAGCCGTCCGCGATCCTGTACGTGGCCCCTGCA
AAGGCCGGAGCTCCAAGCGAGCCCTGCCAAGCCCTCGGGGGAGACGGCCGCCGACTCCATGATCCCCGAGGAGGAGGACGATGAAGACGA
CGAGGACGGCGGGGGACGGGCCGGCTCGGCCATGGCGATCGGCGGCGGCGGCGGGAGCGGCACGCTGGGCTCCGGGCTGCTCCTTGAGGA
CTCGGCCCGGGTGCTGGCACCCGGAGGGCAAGACCCCGGGTCTGGGCCAGCCACCGCGGCGGGCGGGCTGAGCGGGGGTACACAGGCGCT
GCTGCAGCCTCAGCAACCGCTGCCACCGCCGCAGCCGGGGGCGGCTGGGGGCTCCGGGCAGCCGAGGAAATGTTCGTCGCGGCGGAACGC
CTGGGGAAACCTGTCCTACGCGGACCTGATCACCCGCGCCATCGAGAGCTCCCCGGACAAACGGCTCACTCTGTCCCAGATCTACGAGTG
GATGGTGCGTTGCGTGCCCTACTTCAAGGATAAGGGCGACAGCAACAGCTCTGCCGGCTGGAAGGATTTAGTCGTCCGTGTTGTTTTTAT
TCTTGGCAACCTGACGGCAAAAAATAACCAGGCTCGTGAACAATTTTCCAAAGAGAAAGGGAGCATCCAAACTCTGCTGTCATTATTCCA
GACGTTCCATCAGCTGGATCTGCATTCCCAGAAGCCGGTGGGCCAACGAGGCGAGCAGCACAGGGCGCAGAGGCCGCCGTCAGAGGCAGA
GGACGTGCTCATCAAGCTGACTCGTGTGCTGGCCAACATTGCCATCCACCCGGGCGTGGGCCCGGTGCTGGCCGCCAACCCGGGGATAGT
GGGCCTGCTCCTGACCACGCTGGAATACAAGTCACTTGATGATTGTGAGGAGCTGGTGATCAATGCTACAGCGACAATCAACAATTTATC
TTACTACCAAGTGAAGAATTCCATAATTCAAGACAAAAAGCTATATATTGCTGAATTGCTCTTAAAGCTTCTTGTCAGTAACAACATGGA
TGGAATCCTGGAGGCTGTGCGTGTTTTCGGAAATCTCTCCCAGGACCATGATGTCTGCGATTTCATTGTGCAGAACAATGTCCACAGGTT
CATGATGGCGCTGCTGGATGCTCAGCATCAGGATATCTGCTTTTCTGCCTGTGGTGTTCTCCTCAATCTCACTGTGGATAAAGACAAGCG
TGTCATCTTGAAAGAAGGAGGTGGCATTAAAAAGTTAGTGGACTGTTTAAGAGATTTGGGTCCTACTGATTGGCAGCTGGCCTGCTTGGT
TTGTAAAACTTTATGGAACTTCAGTGAAAACATCACTAATGCTTCGTCATGTTTTGGAAATGAAGACACCAACACACTCTTACTCTTGCT
CTCATCATTTTTAGATGAAGAACTAGCACTGGATGGCAGTTTTGATCCAGACCTAAAAAACTATCACAAACTCCATTGGGAAACAGAATT
CAAACCTGTGGCACAGCAGCTTCTAAACCGAATTCAGAGACATCACACCTTCCTGGAACCCCTGCCCATTCCCTCTTTCTAACATGATGC
AGATTAACAGTAGAAACGAGAACTCACGTCTCCCTCATTCTTAAGAACTGGTAACAAACGTGAACATTTTTTTCAGCATTAACAAATGTG
GAAAGTTTTTCAAGAACTGGTTTTAGTGAGTAGCTGAAGTATTTTTTAAAATTAAGCATTTCTTCTTGTTAGGTATTATGGAAAAATGAA
TATACACATTATATTTCCTGTTGAGAGAAATGTAAGATGAAAATATGTGCATTTTCAAGTAAATGACTTTTTCTTCTATTCTCTATTAAA
CAATTTAGTTCTAGTCTTAAAATCTTGATTTAACAATTTTGGAATTGAAGTGTTCATAAGTTAAATGAACTGTGCAATGAAGGCTGTTAG
ATTATATAGAAAGAAGGGTAGGCAACATGAGTGGAACACGTTACAACATAGGATCTGTACTAATTCTTACTATGTCAAATAATAAATGCT

>In-frame_ENST00000406360_ENST00000392644_TCGA-32-1970-01A_FOXO3_chr6_108883032_+_ARMC2_chr6_109274236_length(amino acids)=588AA_start in transcript=205_stop in transcript=1971
MVLPQAAAAAPGSRSLRGVHVPPPLHPAPAREESARAPAAGGRAAKMAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASP
AKPSGETAADSMIPEEEDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLSGGTQALLQPQQPLP
PPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSAGWKDLVVRVVFILGNLTAKN
NQAREQFSKEKGSIQTLLSLFQTFHQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLE
YKSLDDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLLKLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQ
HQDICFSACGVLLNLTVDKDKRVILKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSFLDEEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FOXO3-ARMC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FOXO3-ARMC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FOXO3-ARMC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFOXO3C0002152Alloxan Diabetes2CTD_human
HgeneFOXO3C0011853Diabetes Mellitus, Experimental2CTD_human
HgeneFOXO3C0038433Streptozotocin Diabetes2CTD_human
HgeneFOXO3C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneFOXO3C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneFOXO3C0014072Experimental Autoimmune Encephalomyelitis1CTD_human
HgeneFOXO3C0024117Chronic Obstructive Airway Disease1CTD_human
HgeneFOXO3C0028754Obesity1CTD_human
HgeneFOXO3C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneFOXO3C1527303Chronic Airflow Obstruction1CTD_human