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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:FOXRED2-IFT27 (FusionGDB2 ID:31144) |
Fusion Gene Summary for FOXRED2-IFT27 |
Fusion gene summary |
Fusion gene information | Fusion gene name: FOXRED2-IFT27 | Fusion gene ID: 31144 | Hgene | Tgene | Gene symbol | FOXRED2 | IFT27 | Gene ID | 80020 | 11020 |
Gene name | FAD dependent oxidoreductase domain containing 2 | intraflagellar transport 27 | |
Synonyms | ERFAD | BBS19|FAP156|RABL4|RAYL | |
Cytomap | 22q12.3 | 22q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | FAD-dependent oxidoreductase domain-containing protein 2ER flavoprotein associated with degradationendoplasmic reticulum flavoprotein associated with degradation | intraflagellar transport protein 27 homologRAB, member of RAS oncogene family-like 4rab-like protein 4 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q8IWF2 | . | |
Ensembl transtripts involved in fusion gene | ENST00000397224, ENST00000216187, ENST00000366463, ENST00000397223, | ENST00000340630, ENST00000453009, ENST00000433985, ENST00000476548, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 2 X 1=2 |
# samples | 3 | 1 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/2*10)=2.32192809488736 | |
Context | PubMed: FOXRED2 [Title/Abstract] AND IFT27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FOXRED2(36897288)-IFT27(37163906), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across FOXRED2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across IFT27 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-VQ-A8E2-01A | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
ChimerDB4 | STAD | TCGA-VQ-A8E2-01A | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
ChimerDB4 | STAD | TCGA-VQ-A8E2-01A | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
ChimerDB4 | STAD | TCGA-VQ-A8E2-01A | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
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Fusion Gene ORF analysis for FOXRED2-IFT27 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000397224 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-5UTR | ENST00000397224 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-5UTR | ENST00000397224 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-intron | ENST00000397224 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
Frame-shift | ENST00000216187 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-5UTR | ENST00000216187 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-5UTR | ENST00000216187 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-intron | ENST00000216187 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
intron-3CDS | ENST00000366463 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
intron-5UTR | ENST00000366463 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
intron-5UTR | ENST00000366463 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
intron-intron | ENST00000366463 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
In-frame | ENST00000397223 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-5UTR | ENST00000397223 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-5UTR | ENST00000397223 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-intron | ENST00000397223 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
5CDS-intron | ENST00000397224 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000397224 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000397224 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000397224 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000216187 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000216187 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000216187 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000216187 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
intron-intron | ENST00000366463 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
intron-intron | ENST00000366463 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
intron-intron | ENST00000366463 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
intron-intron | ENST00000366463 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000397223 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000397223 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000397223 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
5CDS-intron | ENST00000397223 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37164223 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000397224 | FOXRED2 | chr22 | 36897288 | - | ENST00000340630 | IFT27 | chr22 | 37163906 | - | 1943 | 1310 | 1 | 1833 | 610 |
ENST00000397223 | FOXRED2 | chr22 | 36897288 | - | ENST00000340630 | IFT27 | chr22 | 37163906 | - | 1957 | 1324 | 93 | 1847 | 584 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000397224 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - | 0.004173622 | 0.9958263 |
ENST00000397223 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - | 0.003432325 | 0.9965676 |
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Fusion Genomic Features for FOXRED2-IFT27 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FOXRED2-IFT27 |
Go to FGviewer for the breakpoints of chr22:36897288-chr22:37163906 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FOXRED2 | . |
FUNCTION: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. {ECO:0000269|PubMed:19706418}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | IFT27 | chr22:36897288 | chr22:37163906 | ENST00000340630 | 0 | 7 | 123_126 | 11.333333333333334 | 186.0 | Nucleotide binding | GTP | |
Tgene | IFT27 | chr22:36897288 | chr22:37163906 | ENST00000340630 | 0 | 7 | 12_19 | 11.333333333333334 | 186.0 | Nucleotide binding | GTP | |
Tgene | IFT27 | chr22:36897288 | chr22:37163906 | ENST00000340630 | 0 | 7 | 64_68 | 11.333333333333334 | 186.0 | Nucleotide binding | GTP | |
Tgene | IFT27 | chr22:36897288 | chr22:37163906 | ENST00000433985 | 0 | 7 | 123_126 | 11.333333333333334 | 187.0 | Nucleotide binding | GTP | |
Tgene | IFT27 | chr22:36897288 | chr22:37163906 | ENST00000433985 | 0 | 7 | 12_19 | 11.333333333333334 | 187.0 | Nucleotide binding | GTP | |
Tgene | IFT27 | chr22:36897288 | chr22:37163906 | ENST00000433985 | 0 | 7 | 64_68 | 11.333333333333334 | 187.0 | Nucleotide binding | GTP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | FOXRED2 | chr22:36897288 | chr22:37163906 | ENST00000216187 | - | 5 | 9 | 681_684 | 405.3333333333333 | 685.0 | Motif | Prevents secretion from ER |
Hgene | FOXRED2 | chr22:36897288 | chr22:37163906 | ENST00000397223 | - | 4 | 8 | 681_684 | 405.3333333333333 | 685.0 | Motif | Prevents secretion from ER |
Hgene | FOXRED2 | chr22:36897288 | chr22:37163906 | ENST00000397224 | - | 5 | 9 | 681_684 | 405.3333333333333 | 685.0 | Motif | Prevents secretion from ER |
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Fusion Gene Sequence for FOXRED2-IFT27 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000397224_ENST00000340630_TCGA-VQ-A8E2-01A_FOXRED2_chr22_36897288_-_IFT27_chr22_37163906_length(transcript)=1943nt_BP=1310nt ATTGGTCCGGGCGCGAGGGGCGGAGCCGCCGCGGAGCAAGCGAGCCAAGCGCGGCCTCATTAGACCACGGGTTGCAGCCGGAGCGGCTGG GAGGATGGGCCTCTCCGCTGCGGCCCCGTTGTGGGGTCCCCCGGGGCTGCTCCTGGCCATCGCCCTGCACCCAGCGCTGTCGGTGCCCCC GCGCCGGGACTACTGCGTGCTGGGCGCTGGGCCCGCGGGCCTGCAGATGGCCTACTTCCTGCAGCGCGCTGGACGCGACTACGCAGTGTT CGAGCGGGCCCCGCGGCCCGGCAGCTTCTTCACACGCTACCCGCGGCACCGCAAGCTCATCAGCATCAACAAGCGGTACACGGGCAAGGC TAACGCCGAGTTCAACCTCCGCCACGACTGGAACTCTCTGCTCAGCCACGACCCCCGGCTGCTCTTCAGACACTACTCGCGTGCCTACTT CCCCGACGCCCGCGACATGGTGCGCTACCTGGGTGACTTCGCGGACACGCTGGGGCTCCGTGTCCAGTACAACACCACCATCGCCCACGT CACTCTGGACAAGGACCGACAGGCCTGGAATGGCCACTACTTCATCCTAACTGACCAGAAGGGCCAGGTGCATCAGTGCAGCGTCCTCTT TGTAGCCACTGGTTTATCAGTCCCCAACCAGGTTGACTTCCCTGGCTCCGAATATGCAGAGGGTTACGAGTCCGTGTCCGTGGACCCTGA GGACTTTGTAGGCCAGAATGTGCTGATCCTGGGTCGTGGGAACTCGGCCTTTGAGACAGCAGAGAACATCTTGGGTGTCACAAACTTTAT CCATATGCTCAGCCGCTCCCGGGTCCGTCTGTCCTGGGCCACCCACTACGTTGGAGACCTCAGAGCCATCAACAATGGCCTGCTGGATAC CTACCAGCTCAAGTCCCTGGACGGGCTGCTCGAGTCTGACCTGACGGATCTGGCCATCCTGAAGGACAGCAAAGGCAAGTTCCATGTCAC CCCGAAATTCTTCCTGGAAGAAGCCAACACCAACCAGAGTGCCGACTCCATCACCCTCCCCCAGGACGACAATGACAACTTTGCCATGCG CGTGCCCTATGACCGGGTAATCCGCTGCCTGGGCTGGAACTTTGACTTCTCCATTTTCAATAAGTCCCTCAGACTTAACTCGGGAAATGC ATTCGGCAAGAAGTACCCGCTGATTCGAGCTAGCTACGAATCCAAAGGAAGCCGGGGTCTGTTTATCCTGGGTACTGCCAGCCACTCGGT GGACTACCGGAAATCTGCTGGGGGCTTCATCCACGGATTCCGATACACAGACCCAGCAGTGGGCAAGACCGCCCTGGCACAGATCTTCCG CAGTGATGGAGCCCATTTCCAGAAAAGCTACACCCTGACAACAGGAATGGATTTGGTGGTGAAGACAGTGCCAGTTCCTGACACGGGAGA CAGTGTGGAACTCTTCATTTTTGACTCTGCTGGCAAGGAGCTGTTTTCGGAAATGCTGGATAAATTGTGGGAGAGTCCCAATGTCTTATG TCTCGTCTATGATGTGACCAATGAAGAATCCTTCAACAACTGCAGCAAGTGGCTGGAGAAGGCTCGGTCACAGGCTCCAGGCATCTCTCT CCCAGGTGTTTTAGTTGGGAACAAGACAGACCTGGCCGGCAGACGAGCAGTGGACTCAGCTGAGGCCCGGGCATGGGCGCTGGGCCAGGG CCTGGAATGTTTTGAAACATCCGTGAAAGAGATGGAAAACTTCGAAGCCCCTTTCCACTGCCTTGCCAAGCAGTTCCACCAGCTGTACCG GGAGAAGGTGGAGGTTTTCCGGGCCCTGGCATGACGAGCTGGAGCAGATCGTGCTGCACAACCGGAGAAGACAGAATTACCTCTGCTCTT >In-frame_ENST00000397224_ENST00000340630_TCGA-VQ-A8E2-01A_FOXRED2_chr22_36897288_-_IFT27_chr22_37163906_length(amino acids)=610AA_start in transcript=1_stop in transcript=1833 LVRARGAEPPRSKRAKRGLIRPRVAAGAAGRMGLSAAAPLWGPPGLLLAIALHPALSVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVF ERAPRPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSLLSHDPRLLFRHYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTIAHV TLDKDRQAWNGHYFILTDQKGQVHQCSVLFVATGLSVPNQVDFPGSEYAEGYESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFI HMLSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLESDLTDLAILKDSKGKFHVTPKFFLEEANTNQSADSITLPQDDNDNFAMR VPYDRVIRCLGWNFDFSIFNKSLRLNSGNAFGKKYPLIRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTDPAVGKTALAQIFR SDGAHFQKSYTLTTGMDLVVKTVPVPDTGDSVELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISL -------------------------------------------------------------- >In-frame_ENST00000397223_ENST00000340630_TCGA-VQ-A8E2-01A_FOXRED2_chr22_36897288_-_IFT27_chr22_37163906_length(transcript)=1957nt_BP=1324nt TGACCCAGATTGCAGTGAGAGTTCCCGCAGGCCCCGCCTCTTTCTGGGCCTCGTGTCTCCCAGCCGCCGGGCCGGGTGCGAGGCCTTACC CCTCTGATCTGCTGCAGGATGGGCCTCTCCGCTGCGGCCCCGTTGTGGGGTCCCCCGGGGCTGCTCCTGGCCATCGCCCTGCACCCAGCG CTGTCGGTGCCCCCGCGCCGGGACTACTGCGTGCTGGGCGCTGGGCCCGCGGGCCTGCAGATGGCCTACTTCCTGCAGCGCGCTGGACGC GACTACGCAGTGTTCGAGCGGGCCCCGCGGCCCGGCAGCTTCTTCACACGCTACCCGCGGCACCGCAAGCTCATCAGCATCAACAAGCGG TACACGGGCAAGGCTAACGCCGAGTTCAACCTCCGCCACGACTGGAACTCTCTGCTCAGCCACGACCCCCGGCTGCTCTTCAGACACTAC TCGCGTGCCTACTTCCCCGACGCCCGCGACATGGTGCGCTACCTGGGTGACTTCGCGGACACGCTGGGGCTCCGTGTCCAGTACAACACC ACCATCGCCCACGTCACTCTGGACAAGGACCGACAGGCCTGGAATGGCCACTACTTCATCCTAACTGACCAGAAGGGCCAGGTGCATCAG TGCAGCGTCCTCTTTGTAGCCACTGGTTTATCAGTCCCCAACCAGGTTGACTTCCCTGGCTCCGAATATGCAGAGGGTTACGAGTCCGTG TCCGTGGACCCTGAGGACTTTGTAGGCCAGAATGTGCTGATCCTGGGTCGTGGGAACTCGGCCTTTGAGACAGCAGAGAACATCTTGGGT GTCACAAACTTTATCCATATGCTCAGCCGCTCCCGGGTCCGTCTGTCCTGGGCCACCCACTACGTTGGAGACCTCAGAGCCATCAACAAT GGCCTGCTGGATACCTACCAGCTCAAGTCCCTGGACGGGCTGCTCGAGTCTGACCTGACGGATCTGGCCATCCTGAAGGACAGCAAAGGC AAGTTCCATGTCACCCCGAAATTCTTCCTGGAAGAAGCCAACACCAACCAGAGTGCCGACTCCATCACCCTCCCCCAGGACGACAATGAC AACTTTGCCATGCGCGTGCCCTATGACCGGGTAATCCGCTGCCTGGGCTGGAACTTTGACTTCTCCATTTTCAATAAGTCCCTCAGACTT AACTCGGGAAATGCATTCGGCAAGAAGTACCCGCTGATTCGAGCTAGCTACGAATCCAAAGGAAGCCGGGGTCTGTTTATCCTGGGTACT GCCAGCCACTCGGTGGACTACCGGAAATCTGCTGGGGGCTTCATCCACGGATTCCGATACACAGACCCAGCAGTGGGCAAGACCGCCCTG GCACAGATCTTCCGCAGTGATGGAGCCCATTTCCAGAAAAGCTACACCCTGACAACAGGAATGGATTTGGTGGTGAAGACAGTGCCAGTT CCTGACACGGGAGACAGTGTGGAACTCTTCATTTTTGACTCTGCTGGCAAGGAGCTGTTTTCGGAAATGCTGGATAAATTGTGGGAGAGT CCCAATGTCTTATGTCTCGTCTATGATGTGACCAATGAAGAATCCTTCAACAACTGCAGCAAGTGGCTGGAGAAGGCTCGGTCACAGGCT CCAGGCATCTCTCTCCCAGGTGTTTTAGTTGGGAACAAGACAGACCTGGCCGGCAGACGAGCAGTGGACTCAGCTGAGGCCCGGGCATGG GCGCTGGGCCAGGGCCTGGAATGTTTTGAAACATCCGTGAAAGAGATGGAAAACTTCGAAGCCCCTTTCCACTGCCTTGCCAAGCAGTTC CACCAGCTGTACCGGGAGAAGGTGGAGGTTTTCCGGGCCCTGGCATGACGAGCTGGAGCAGATCGTGCTGCACAACCGGAGAAGACAGAA >In-frame_ENST00000397223_ENST00000340630_TCGA-VQ-A8E2-01A_FOXRED2_chr22_36897288_-_IFT27_chr22_37163906_length(amino acids)=584AA_start in transcript=93_stop in transcript=1847 MICCRMGLSAAAPLWGPPGLLLAIALHPALSVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFTRYPRHRKLISINKRY TGKANAEFNLRHDWNSLLSHDPRLLFRHYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWNGHYFILTDQKGQVHQC SVLFVATGLSVPNQVDFPGSEYAEGYESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWATHYVGDLRAINNG LLDTYQLKSLDGLLESDLTDLAILKDSKGKFHVTPKFFLEEANTNQSADSITLPQDDNDNFAMRVPYDRVIRCLGWNFDFSIFNKSLRLN SGNAFGKKYPLIRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVP DTGDSVELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVLVGNKTDLAGRRAVDSAEARAWA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FOXRED2-IFT27 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FOXRED2-IFT27 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FOXRED2-IFT27 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IFT27 | C3889475 | BARDET-BIEDL SYNDROME 19 | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | IFT27 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | IFT27 | C0152427 | Polydactyly | 1 | GENOMICS_ENGLAND |
Tgene | IFT27 | C0752166 | Bardet-Biedl Syndrome | 1 | ORPHANET |