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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:FRMD8-PACS1 (FusionGDB2 ID:31278) |
Fusion Gene Summary for FRMD8-PACS1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: FRMD8-PACS1 | Fusion gene ID: 31278 | Hgene | Tgene | Gene symbol | FRMD8 | PACS1 | Gene ID | 83786 | 55690 |
Gene name | FERM domain containing 8 | phosphofurin acidic cluster sorting protein 1 | |
Synonyms | FKSG44|iTAP | MRD17|SHMS | |
Cytomap | 11q13.1 | 11q13.1-q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | FERM domain-containing protein 8band4.1 inhibitor LRP interactorbiliiRhom Tail-Associated Protein | phosphofurin acidic cluster sorting protein 1PACS-1cytosolic sorting protein PACS-1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9BZ67 | . | |
Ensembl transtripts involved in fusion gene | ENST00000317568, ENST00000531296, ENST00000355991, ENST00000416776, | ENST00000320580, ENST00000529757, ENST00000524815, | |
Fusion gene scores | * DoF score | 11 X 8 X 8=704 | 21 X 18 X 12=4536 |
# samples | 16 | 26 | |
** MAII score | log2(16/704*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/4536*10)=-4.12483711191377 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FRMD8 [Title/Abstract] AND PACS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FRMD8(65167330)-PACS1(65977833), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FRMD8 | GO:1904469 | positive regulation of tumor necrosis factor secretion | 29897333 |
Fusion gene breakpoints across FRMD8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across PACS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUSC | TCGA-85-8276-01A | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
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Fusion Gene ORF analysis for FRMD8-PACS1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000317568 | ENST00000320580 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
5CDS-intron | ENST00000317568 | ENST00000529757 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
5CDS-intron | ENST00000317568 | ENST00000524815 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
intron-3CDS | ENST00000531296 | ENST00000320580 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
intron-intron | ENST00000531296 | ENST00000529757 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
intron-intron | ENST00000531296 | ENST00000524815 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
In-frame | ENST00000355991 | ENST00000320580 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
5CDS-intron | ENST00000355991 | ENST00000529757 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
5CDS-intron | ENST00000355991 | ENST00000524815 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
In-frame | ENST00000416776 | ENST00000320580 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
5CDS-intron | ENST00000416776 | ENST00000529757 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
5CDS-intron | ENST00000416776 | ENST00000524815 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000317568 | FRMD8 | chr11 | 65167330 | + | ENST00000320580 | PACS1 | chr11 | 65977833 | + | 5005 | 1090 | 127 | 3537 | 1136 |
ENST00000355991 | FRMD8 | chr11 | 65167330 | + | ENST00000320580 | PACS1 | chr11 | 65977833 | + | 4799 | 884 | 89 | 3331 | 1080 |
ENST00000416776 | FRMD8 | chr11 | 65167330 | + | ENST00000320580 | PACS1 | chr11 | 65977833 | + | 4845 | 930 | 69 | 3377 | 1102 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000317568 | ENST00000320580 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + | 0.001920548 | 0.9980794 |
ENST00000355991 | ENST00000320580 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + | 0.001827689 | 0.9981723 |
ENST00000416776 | ENST00000320580 | FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977833 | + | 0.00175324 | 0.9982468 |
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Fusion Genomic Features for FRMD8-PACS1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977832 | + | 0.001010581 | 0.9989894 |
FRMD8 | chr11 | 65167330 | + | PACS1 | chr11 | 65977832 | + | 0.001010581 | 0.9989894 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for FRMD8-PACS1 |
Go to FGviewer for the breakpoints of chr11:65167330-chr11:65977833 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FRMD8 | . |
FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | PACS1 | chr11:65167330 | chr11:65977833 | ENST00000320580 | 1 | 24 | 353_377 | 148.0 | 964.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PACS1 | chr11:65167330 | chr11:65977833 | ENST00000320580 | 1 | 24 | 279_283 | 148.0 | 964.0 | Compositional bias | Note=Poly-Glu | |
Tgene | PACS1 | chr11:65167330 | chr11:65977833 | ENST00000320580 | 1 | 24 | 168_175 | 148.0 | 964.0 | Region | Note=Involved in binding to AP-1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | FRMD8 | chr11:65167330 | chr11:65977833 | ENST00000317568 | + | 8 | 11 | 30_376 | 309.0 | 465.0 | Domain | FERM |
Hgene | FRMD8 | chr11:65167330 | chr11:65977833 | ENST00000355991 | + | 7 | 10 | 30_376 | 253.0 | 409.0 | Domain | FERM |
Tgene | PACS1 | chr11:65167330 | chr11:65977833 | ENST00000320580 | 1 | 24 | 112_115 | 148.0 | 964.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PACS1 | chr11:65167330 | chr11:65977833 | ENST00000320580 | 1 | 24 | 35_40 | 148.0 | 964.0 | Compositional bias | Note=Poly-Gln | |
Tgene | PACS1 | chr11:65167330 | chr11:65977833 | ENST00000320580 | 1 | 24 | 55_84 | 148.0 | 964.0 | Compositional bias | Note=Ser-rich | |
Tgene | PACS1 | chr11:65167330 | chr11:65977833 | ENST00000320580 | 1 | 24 | 5_44 | 148.0 | 964.0 | Compositional bias | Note=Gly-rich | |
Tgene | PACS1 | chr11:65167330 | chr11:65977833 | ENST00000320580 | 1 | 24 | 62_65 | 148.0 | 964.0 | Compositional bias | Note=Poly-Ala |
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Fusion Gene Sequence for FRMD8-PACS1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000317568_ENST00000320580_TCGA-85-8276-01A_FRMD8_chr11_65167330_+_PACS1_chr11_65977833_length(transcript)=5005nt_BP=1090nt GCCTCGGGCGCCGCGCTTCCTCCCGCCGTGGCTTCCGCGTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGG CGGGCTTGGCGGCGGGGCAGGATTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGATGGACGGGACAGAAGG CAGTGCCGGGCAGCCCGGCCCCGCTGAGCGATCCCACCGAAGCAGCGTGTCCTCCGTGGGAGCCCGAGCGGCTGACGTGCTGGTATACCT AGCGGATGACACGGTGGTGCCCCTGGCTGTGGAGAACCTGCCCTCGCTCAGTGCCCATGAGCTGCACCGCGCTGTCCGCGAGGTCCTGCA GCTTCCAGACATCGCCCTGGATGTCTTCGCGCTCTGGCTGGTCTCCCCTCTGCTGGAGGTGCAGCTGAAACCCAAGCACCAGCCCTACAA GCTGGGACGCCAGTGGCCGGAGCTGCTGCTGCGCTTCACCAGTGCCCCAGACGATGACGTGGCCATGGATGAGCCTTTCCTGCAGTTCCG AAGGAACGTGTTCTTCCCAAAGCGGCGGGAGCTCCAGATCCATGACGAGGAGGTCCTGCGGCTGCTCTATGAGGAGGCCAAGGGCAACGT GCTGGCTGCACGGTACCCGTGCGACGTGGAGGACTGCGAGGCTCTGGGCGCCCTGGTGTGCCGCGTGCAGCTTGGGCCCTACCAGCCCGG CCGGCCGGCAGCCTGCGACCTGAGGGAGAAGCTGGACTCCTTCCTCCCTGCCCACCTCTGTAAGCGGGGCCAGAGTCTCTTTGCTGCCCT CCGGGGCCGTGGGGCCAGGGCCGGGCCGGGCGAGCAGGGCCTGCTGAACGCCTACCGCCAGGTGCAGGAGGTCAGCAGCGACGGCGGGTG CGAGGCCGCCCTGGGCACCCACTACCGCGCCTATCTCCTCAAGTGCCACGAGCTGCCGTTTTATGGGTGTGCCTTCTTCCACGGTGAGGT TGACAAGCCGGCCCAAGGCTTTTTGCACCGGGGTGGGCGCAAGCCAGTTTCTGTGGCCATCAGTCTGGAAGGCGTGCACGTCATCGATAG CAGAGAGAAGGGTTCAAAAAGAATTCTTCGCTCCAACGAGATCGTCCTTCCAGCTAGTGGACTGGTGGAAACAGAGCTCCAATTAACCTT CTCCCTTCAGTACCCTCATTTCCTTAAGCGAGATGCCAACAAGCTGCAGATCATGCTGCAAAGGAGAAAACGTTACAAGAATCGGACCAT CTTGGGCTATAAGACCTTGGCCGTGGGACTCATCAACATGGCAGAGGTGATGCAGCATCCTAATGAAGGCGCACTGGTGCTTGGCCTACA CAGCAACGTGAAGGATGTCTCTGTGCCTGTGGCAGAAATAAAGATCTACTCCCTGTCCAGCCAACCCATTGACCATGAAGGAATCAAATC CAAGCTTTCTGATCGTTCTCCTGATATTGACAATTATTCTGAGGAAGAGGAAGAGAGTTTCTCATCAGAACAGGAAGGCAGTGATGATCC ATTGCATGGGCAGGACTTGTTCTACGAAGACGAAGATCTCCGGAAAGTGAAGAAGACCCGGAGGAAACTAACCTCAACCTCTGCCATCAC AAGGCAACCTAACATCAAACAGAAGTTTGTGGCCCTCCTGAAGCGGTTTAAAGTTTCAGATGAGGTGGGCTTTGGGCTGGAGCATGTGTC CCGCGAGCAGATCCGGGAAGTGGAAGAGGACTTGGATGAATTGTATGACAGTCTGGAGATGTACAACCCCAGCGACAGTGGCCCTGAGAT GGAGGAGACAGAAAGCATCCTCAGCACGCCAAAGCCCAAGCTCAAGCCTTTCTTTGAGGGGATGTCGCAGTCCAGCTCCCAGACGGAGAT TGGCAGCCTCAACAGCAAAGGCAGCCTCGGAAAAGACACCACCAGCCCTATGGAATTGGCTGCTCTAGAAAAAATTAAATCTACTTGGAT TAAAAACCAAGATGACAGCTTGACTGAAACAGACACTCTGGAAATCACTGACCAGGACATGTTTGGAGATGCCAGCACGAGTCTGGTTGT GCCGGAGAAAGTCAAAACTCCCATGAAGTCCAGTAAAACGGATCTCCAGGGCTCTGCCTCCCCCAGCAAAGTGGAGGGGGTGCACACACC CCGGCAGAAGAGGAGCACGCCCCTGAAGGAGCGGCAGCTCTCCAAGCCCCTAAGTGAGAGGACCAACAGTTCCGACAGCGAGCGCTCCCC AGATCTGGGCCACAGCACGCAGATTCCAAGAAAGGTGGTGTATGACCAGCTCAATCAGATCCTGGTGTCAGATGCAGCCCTCCCAGAAAA TGTCATTCTGGTGAACACCACTGACTGGCAGGGCCAGTATGTGGCTGAGCTGCTCCAGGACCAGCGGAAGCCTGTGGTGTGCACCTGCTC CACCGTGGAGGTCCAGGCCGTGCTGTCCGCCCTGCTCACCCGGATCCAGCGCTACTGCAACTGCAACTCTTCCATGCCGAGGCCAGTGAA GGTGGCTGCTGTGGGAGGCCAGAGCTACCTGAGCTCCATCCTCAGGTTCTTTGTCAAGTCCCTGGCCAACAAGACCTCCGACTGGCTTGG CTACATGCGCTTCCTCATCATCCCCCTCGGTTCTCACCCTGTGGCCAAATACTTGGGGTCAGTCGACAGTAAATACAGTAGTTCCTTCCT GGATTCTGGTTGGAGAGATCTGTTCAGTCGCTCGGAGCCACCAGTGTCAGAGCAACTGGACGTGGCAGGGCGGGTGATGCAGTACGTCAA CGGGGCAGCCACGACACACCAGCTTCCCGTGGCCGAAGCCATGCTGACTTGCCGGCATAAGTTCCCTGATGAAGACTCCTATCAGAAGTT TATTCCCTTCATTGGCGTGGTGAAGGTGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCT TACTGTGCCCTCCACATCACCACCCTCCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGC CCTGGCCATCGTGGGGAGCCCTAATAGCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAG GAGGGAAGGCGACAAGAGGGACGCCAGCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGG GGAGGCCCAGCTTTCTGGCACCATGGCCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACC CCGAGAAAAGGAGGTGGATTCTAAGAGCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAG AGTGTCCATCGATGGGGTCGAGTGGAGTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGG ACTCTTCAGTGGCAGCAAGGCCACCTGAGGCCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCAGCCTCACCGCCTGCGGGCAG GGGGAGGCCAGCAGGCCCGGGCCCAGCACCCCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGTCCCGAAGGACACTGCCACAG GGACGCCTTCCCTCCCCTCCCCTCCAGCCCACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTCTCCCTCCTGCTCCAGGCCCA AGGCGTGTTGGTTTTGCCTTCTGGTGCCCATAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCGACTTCCAAACTCTTCCTTGT GGTATCAGTTTCCTTCTCGGAAATGAGAAAGCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCCCCAGCCCCTCCAGCCACCAG GGTGTCCTCTAGGATGCAGCTGCCAGATCCACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTCAACTCTTATGGGGTTCTCCA CCTGCCCCAGAGCTTCTCAAGGGAGGGTAAGGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTCACAGGGGCAGGAGGCAGCTC CCCTGCCTCCAGGACCCTGTTGCTATGGTGACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCCCCACCACCCGTGCACGACTT CCTCACCACCCCCAGGTTCCCTGCAGATGTCGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCAAGTCTCTTGGTTGTACCATG TGACACACCCTGTGCACTGGTCGCTGTCTTCGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCCTCCCAGCCCCTCACCCAGCA CAGCTCTGCCTGGACTTGGAGAGATGGGAGGCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCAGACATTCTGTTTCATCTCCC ATTCATCTCCCTCCTCCCACCGTGTCAGTTTTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGCCCCAGCCTGGGCCCAGACCC ATCCTCCCAGCCAGGTTTCCCTCCAGCAGGCTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGGTCTGAGCCCCTCATTCCTGA CCGTCCGTGTTCTCAGGAGTGGTTGAGGACACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGCCATCTGCGCCCCACAGCCCC TTTGGAGCTTTTCTCTTGTCCTCTCACTCCTTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGTTTTTCTCATTCTCCATACCT CCCCCAAGCTCTCCTCCAGCCCTTCCCAGGGCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAGAGGAGATGGGGGTGGGAGGG >In-frame_ENST00000317568_ENST00000320580_TCGA-85-8276-01A_FRMD8_chr11_65167330_+_PACS1_chr11_65977833_length(amino acids)=1136AA_start in transcript=127_stop in transcript=3537 MPLRWRALRPCEMDGTEGSAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLPSLSAHELHRAVREVLQLPDIALDVFALW LVSPLLEVQLKPKHQPYKLGRQWPELLLRFTSAPDDDVAMDEPFLQFRRNVFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDC EALGALVCRVQLGPYQPGRPAACDLREKLDSFLPAHLCKRGQSLFAALRGRGARAGPGEQGLLNAYRQVQEVSSDGGCEAALGTHYRAYL LKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVSVAISLEGVHVIDSREKGSKRILRSNEIVLPASGLVETELQLTFSLQYPHFLKRDA NKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNY SEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLD ELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKIKSTWIKNQDDSLTETDT LEITDQDMFGDASTSLVVPEKVKTPMKSSKTDLQGSASPSKVEGVHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKV VYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSS ILRFFVKSLANKTSDWLGYMRFLIIPLGSHPVAKYLGSVDSKYSSSFLDSGWRDLFSRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAE AMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYG DVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVI -------------------------------------------------------------- >In-frame_ENST00000355991_ENST00000320580_TCGA-85-8276-01A_FRMD8_chr11_65167330_+_PACS1_chr11_65977833_length(transcript)=4799nt_BP=884nt GTCGCTTCCCGGTCAGCTGCGTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGATTCCAGGCAGGAGCCT TGCCTCTCAGGTGGCGGGCTCTGCGACCCTGCGAGATGGACGGGACAGAAGGCAGTGCCGGGCAGCCCGGCCCCGCTGAGCGATCCCACC GAAGCAGCGTGTCCTCCGTGGGAGCCCGAGAGGTGCAGCTGAAACCCAAGCACCAGCCCTACAAGCTGGGACGCCAGTGGCCGGAGCTGC TGCTGCGCTTCACCAGTGCCCCAGACGATGACGTGGCCATGGATGAGCCTTTCCTGCAGTTCCGAAGGAACGTGTTCTTCCCAAAGCGGC GGGAGCTCCAGATCCATGACGAGGAGGTCCTGCGGCTGCTCTATGAGGAGGCCAAGGGCAACGTGCTGGCTGCACGGTACCCGTGCGACG TGGAGGACTGCGAGGCTCTGGGCGCCCTGGTGTGCCGCGTGCAGCTTGGGCCCTACCAGCCCGGCCGGCCGGCAGCCTGCGACCTGAGGG AGAAGCTGGACTCCTTCCTCCCTGCCCACCTCTGTAAGCGGGGCCAGAGTCTCTTTGCTGCCCTCCGGGGCCGTGGGGCCAGGGCCGGGC CGGGCGAGCAGGGCCTGCTGAACGCCTACCGCCAGGTGCAGGAGGTCAGCAGCGACGGCGGGTGCGAGGCCGCCCTGGGCACCCACTACC GCGCCTATCTCCTCAAGTGCCACGAGCTGCCGTTTTATGGGTGTGCCTTCTTCCACGGTGAGGTTGACAAGCCGGCCCAAGGCTTTTTGC ACCGGGGTGGGCGCAAGCCAGTTTCTGTGGCCATCAGTCTGGAAGGCGTGCACGTCATCGATAGCAGAGAGAAGGGTTCAAAAAGAATTC TTCGCTCCAACGAGATCGTCCTTCCAGCTAGTGGACTGGTGGAAACAGAGCTCCAATTAACCTTCTCCCTTCAGTACCCTCATTTCCTTA AGCGAGATGCCAACAAGCTGCAGATCATGCTGCAAAGGAGAAAACGTTACAAGAATCGGACCATCTTGGGCTATAAGACCTTGGCCGTGG GACTCATCAACATGGCAGAGGTGATGCAGCATCCTAATGAAGGCGCACTGGTGCTTGGCCTACACAGCAACGTGAAGGATGTCTCTGTGC CTGTGGCAGAAATAAAGATCTACTCCCTGTCCAGCCAACCCATTGACCATGAAGGAATCAAATCCAAGCTTTCTGATCGTTCTCCTGATA TTGACAATTATTCTGAGGAAGAGGAAGAGAGTTTCTCATCAGAACAGGAAGGCAGTGATGATCCATTGCATGGGCAGGACTTGTTCTACG AAGACGAAGATCTCCGGAAAGTGAAGAAGACCCGGAGGAAACTAACCTCAACCTCTGCCATCACAAGGCAACCTAACATCAAACAGAAGT TTGTGGCCCTCCTGAAGCGGTTTAAAGTTTCAGATGAGGTGGGCTTTGGGCTGGAGCATGTGTCCCGCGAGCAGATCCGGGAAGTGGAAG AGGACTTGGATGAATTGTATGACAGTCTGGAGATGTACAACCCCAGCGACAGTGGCCCTGAGATGGAGGAGACAGAAAGCATCCTCAGCA CGCCAAAGCCCAAGCTCAAGCCTTTCTTTGAGGGGATGTCGCAGTCCAGCTCCCAGACGGAGATTGGCAGCCTCAACAGCAAAGGCAGCC TCGGAAAAGACACCACCAGCCCTATGGAATTGGCTGCTCTAGAAAAAATTAAATCTACTTGGATTAAAAACCAAGATGACAGCTTGACTG AAACAGACACTCTGGAAATCACTGACCAGGACATGTTTGGAGATGCCAGCACGAGTCTGGTTGTGCCGGAGAAAGTCAAAACTCCCATGA AGTCCAGTAAAACGGATCTCCAGGGCTCTGCCTCCCCCAGCAAAGTGGAGGGGGTGCACACACCCCGGCAGAAGAGGAGCACGCCCCTGA AGGAGCGGCAGCTCTCCAAGCCCCTAAGTGAGAGGACCAACAGTTCCGACAGCGAGCGCTCCCCAGATCTGGGCCACAGCACGCAGATTC CAAGAAAGGTGGTGTATGACCAGCTCAATCAGATCCTGGTGTCAGATGCAGCCCTCCCAGAAAATGTCATTCTGGTGAACACCACTGACT GGCAGGGCCAGTATGTGGCTGAGCTGCTCCAGGACCAGCGGAAGCCTGTGGTGTGCACCTGCTCCACCGTGGAGGTCCAGGCCGTGCTGT CCGCCCTGCTCACCCGGATCCAGCGCTACTGCAACTGCAACTCTTCCATGCCGAGGCCAGTGAAGGTGGCTGCTGTGGGAGGCCAGAGCT ACCTGAGCTCCATCCTCAGGTTCTTTGTCAAGTCCCTGGCCAACAAGACCTCCGACTGGCTTGGCTACATGCGCTTCCTCATCATCCCCC TCGGTTCTCACCCTGTGGCCAAATACTTGGGGTCAGTCGACAGTAAATACAGTAGTTCCTTCCTGGATTCTGGTTGGAGAGATCTGTTCA GTCGCTCGGAGCCACCAGTGTCAGAGCAACTGGACGTGGCAGGGCGGGTGATGCAGTACGTCAACGGGGCAGCCACGACACACCAGCTTC CCGTGGCCGAAGCCATGCTGACTTGCCGGCATAAGTTCCCTGATGAAGACTCCTATCAGAAGTTTATTCCCTTCATTGGCGTGGTGAAGG TGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCT CCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATA GCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCA GCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGG CCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGA GCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGA GTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCT GAGGCCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCAGCCTCACCGCCTGCGGGCAGGGGGAGGCCAGCAGGCCCGGGCCCAG CACCCCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGTCCCGAAGGACACTGCCACAGGGACGCCTTCCCTCCCCTCCCCTCCA GCCCACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTCTCCCTCCTGCTCCAGGCCCAAGGCGTGTTGGTTTTGCCTTCTGGTG CCCATAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCGACTTCCAAACTCTTCCTTGTGGTATCAGTTTCCTTCTCGGAAATGA GAAAGCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCCCCAGCCCCTCCAGCCACCAGGGTGTCCTCTAGGATGCAGCTGCCAG ATCCACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTCAACTCTTATGGGGTTCTCCACCTGCCCCAGAGCTTCTCAAGGGAGG GTAAGGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTCACAGGGGCAGGAGGCAGCTCCCCTGCCTCCAGGACCCTGTTGCTAT GGTGACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCCCCACCACCCGTGCACGACTTCCTCACCACCCCCAGGTTCCCTGCAG ATGTCGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCAAGTCTCTTGGTTGTACCATGTGACACACCCTGTGCACTGGTCGCTG TCTTCGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCCTCCCAGCCCCTCACCCAGCACAGCTCTGCCTGGACTTGGAGAGATG GGAGGCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCAGACATTCTGTTTCATCTCCCATTCATCTCCCTCCTCCCACCGTGTC AGTTTTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGCCCCAGCCTGGGCCCAGACCCATCCTCCCAGCCAGGTTTCCCTCCAG CAGGCTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGGTCTGAGCCCCTCATTCCTGACCGTCCGTGTTCTCAGGAGTGGTTGA GGACACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGCCATCTGCGCCCCACAGCCCCTTTGGAGCTTTTCTCTTGTCCTCTCA CTCCTTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGTTTTTCTCATTCTCCATACCTCCCCCAAGCTCTCCTCCAGCCCTTCC CAGGGCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAGAGGAGATGGGGGTGGGAGGGACTGAGTTGATGTTGGGTTTTTCATT >In-frame_ENST00000355991_ENST00000320580_TCGA-85-8276-01A_FRMD8_chr11_65167330_+_PACS1_chr11_65977833_length(amino acids)=1080AA_start in transcript=89_stop in transcript=3331 MPLRWRALRPCEMDGTEGSAGQPGPAERSHRSSVSSVGAREVQLKPKHQPYKLGRQWPELLLRFTSAPDDDVAMDEPFLQFRRNVFFPKR RELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPAACDLREKLDSFLPAHLCKRGQSLFAALRGRGARAG PGEQGLLNAYRQVQEVSSDGGCEAALGTHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVSVAISLEGVHVIDSREKGSKRI LRSNEIVLPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSV PVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQK FVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGS LGKDTTSPMELAALEKIKSTWIKNQDDSLTETDTLEITDQDMFGDASTSLVVPEKVKTPMKSSKTDLQGSASPSKVEGVHTPRQKRSTPL KERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVL SALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSSILRFFVKSLANKTSDWLGYMRFLIIPLGSHPVAKYLGSVDSKYSSSFLDSGWRDLF SRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPP SSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHSGEAQLSGTM AMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTHVKHFPVGLFSGSKAT -------------------------------------------------------------- >In-frame_ENST00000416776_ENST00000320580_TCGA-85-8276-01A_FRMD8_chr11_65167330_+_PACS1_chr11_65977833_length(transcript)=4845nt_BP=930nt GTCCTTAGCGGGAGCCCGAGTGCGGGCGGTGGCGGGCTTGGCGGCGGGGCAGGATTCCAGGCAGGAGCCTTGCCTCTCAGGTGGCGGGCT CTGCGACCCTGCGAGATGGACGGGACAGAAGGCAGTGCCGGGCAGCCCGGCCCCGCTGAGCGATCCCACCGAAGCAGCGTGTCCTCCGTG GGAGCCCGAGCGGCTGACGTGCTGGTATACCTAGCGGATGACACGGTGGTGCCCCTGGCTGTGGAGAACCTGCCCTCGCTCAGTGCCCAT GAGCTGCACCGCGCTGTCCGCGAGGTCCTGCAGCTTCCAGACATCGCCCTGGATGTCTTCGCGCTCTGGCTGGTCTCCCCTCTGCTGGAT GAGCCTTTCCTGCAGTTCCGAAGGAACGTGTTCTTCCCAAAGCGGCGGGAGCTCCAGATCCATGACGAGGAGGTCCTGCGGCTGCTCTAT GAGGAGGCCAAGGGCAACGTGCTGGCTGCACGGTACCCGTGCGACGTGGAGGACTGCGAGGCTCTGGGCGCCCTGGTGTGCCGCGTGCAG CTTGGGCCCTACCAGCCCGGCCGGCCGGCAGCCTGCGACCTGAGGGAGAAGCTGGACTCCTTCCTCCCTGCCCACCTCTGTAAGCGGGGC CAGAGTCTCTTTGCTGCCCTCCGGGGCCGTGGGGCCAGGGCCGGGCCGGGCGAGCAGGGCCTGCTGAACGCCTACCGCCAGGTGCAGGAG GTCAGCAGCGACGGCGGGTGCGAGGCCGCCCTGGGCACCCACTACCGCGCCTATCTCCTCAAGTGCCACGAGCTGCCGTTTTATGGGTGT GCCTTCTTCCACGGTGAGGTTGACAAGCCGGCCCAAGGCTTTTTGCACCGGGGTGGGCGCAAGCCAGTTTCTGTGGCCATCAGTCTGGAA GGCGTGCACGTCATCGATAGCAGAGAGAAGGGTTCAAAAAGAATTCTTCGCTCCAACGAGATCGTCCTTCCAGCTAGTGGACTGGTGGAA ACAGAGCTCCAATTAACCTTCTCCCTTCAGTACCCTCATTTCCTTAAGCGAGATGCCAACAAGCTGCAGATCATGCTGCAAAGGAGAAAA CGTTACAAGAATCGGACCATCTTGGGCTATAAGACCTTGGCCGTGGGACTCATCAACATGGCAGAGGTGATGCAGCATCCTAATGAAGGC GCACTGGTGCTTGGCCTACACAGCAACGTGAAGGATGTCTCTGTGCCTGTGGCAGAAATAAAGATCTACTCCCTGTCCAGCCAACCCATT GACCATGAAGGAATCAAATCCAAGCTTTCTGATCGTTCTCCTGATATTGACAATTATTCTGAGGAAGAGGAAGAGAGTTTCTCATCAGAA CAGGAAGGCAGTGATGATCCATTGCATGGGCAGGACTTGTTCTACGAAGACGAAGATCTCCGGAAAGTGAAGAAGACCCGGAGGAAACTA ACCTCAACCTCTGCCATCACAAGGCAACCTAACATCAAACAGAAGTTTGTGGCCCTCCTGAAGCGGTTTAAAGTTTCAGATGAGGTGGGC TTTGGGCTGGAGCATGTGTCCCGCGAGCAGATCCGGGAAGTGGAAGAGGACTTGGATGAATTGTATGACAGTCTGGAGATGTACAACCCC AGCGACAGTGGCCCTGAGATGGAGGAGACAGAAAGCATCCTCAGCACGCCAAAGCCCAAGCTCAAGCCTTTCTTTGAGGGGATGTCGCAG TCCAGCTCCCAGACGGAGATTGGCAGCCTCAACAGCAAAGGCAGCCTCGGAAAAGACACCACCAGCCCTATGGAATTGGCTGCTCTAGAA AAAATTAAATCTACTTGGATTAAAAACCAAGATGACAGCTTGACTGAAACAGACACTCTGGAAATCACTGACCAGGACATGTTTGGAGAT GCCAGCACGAGTCTGGTTGTGCCGGAGAAAGTCAAAACTCCCATGAAGTCCAGTAAAACGGATCTCCAGGGCTCTGCCTCCCCCAGCAAA GTGGAGGGGGTGCACACACCCCGGCAGAAGAGGAGCACGCCCCTGAAGGAGCGGCAGCTCTCCAAGCCCCTAAGTGAGAGGACCAACAGT TCCGACAGCGAGCGCTCCCCAGATCTGGGCCACAGCACGCAGATTCCAAGAAAGGTGGTGTATGACCAGCTCAATCAGATCCTGGTGTCA GATGCAGCCCTCCCAGAAAATGTCATTCTGGTGAACACCACTGACTGGCAGGGCCAGTATGTGGCTGAGCTGCTCCAGGACCAGCGGAAG CCTGTGGTGTGCACCTGCTCCACCGTGGAGGTCCAGGCCGTGCTGTCCGCCCTGCTCACCCGGATCCAGCGCTACTGCAACTGCAACTCT TCCATGCCGAGGCCAGTGAAGGTGGCTGCTGTGGGAGGCCAGAGCTACCTGAGCTCCATCCTCAGGTTCTTTGTCAAGTCCCTGGCCAAC AAGACCTCCGACTGGCTTGGCTACATGCGCTTCCTCATCATCCCCCTCGGTTCTCACCCTGTGGCCAAATACTTGGGGTCAGTCGACAGT AAATACAGTAGTTCCTTCCTGGATTCTGGTTGGAGAGATCTGTTCAGTCGCTCGGAGCCACCAGTGTCAGAGCAACTGGACGTGGCAGGG CGGGTGATGCAGTACGTCAACGGGGCAGCCACGACACACCAGCTTCCCGTGGCCGAAGCCATGCTGACTTGCCGGCATAAGTTCCCTGAT GAAGACTCCTATCAGAAGTTTATTCCCTTCATTGGCGTGGTGAAGGTGGGTCTGGTTGAAGACTCTCCCTCCACAGCAGGCGATGGGGAC GATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACATCACCACCCTCCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCC TCCCCATCTATGAGCAGCGCCCTGGCCATCGTGGGGAGCCCTAATAGCCCATATGGGGACGTGATTGGCCTCCAGGTGGACTACTGGCTG GGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAGAGGGACGCCAGCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTG TCCCGCCTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGGCCATGACTGTGGTCACCAAAGAAAAGAACAAGAAAGTTCCCACC ATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTGGATTCTAAGAGCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAG CAGCAGCAGACTATGCTGAGAGTGTCCATCGATGGGGTCGAGTGGAGTGACATCAAGTTCTTCCAGCTGGCAGCCCAGTGGCCCACCCAT GTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGCAAGGCCACCTGAGGCCCTGTCTCCCAGCCACTTTCCCTCCTGGCACTGCCACCA GCCTCACCGCCTGCGGGCAGGGGGAGGCCAGCAGGCCCGGGCCCAGCACCCCTTCCCTGGCACCAGGGTCTGCCTCTCACTCGCCCAGGT CCCGAAGGACACTGCCACAGGGACGCCTTCCCTCCCCTCCCCTCCAGCCCACCCCTGCACAGCCCCTCCTCCTTCCCGCTTTTCCCCTTC TCCCTCCTGCTCCAGGCCCAAGGCGTGTTGGTTTTGCCTTCTGGTGCCCATAGTCCCCTGGACTGAGTCCCCCAGGCCTTCCTTCACCCG ACTTCCAAACTCTTCCTTGTGGTATCAGTTTCCTTCTCGGAAATGAGAAAGCTGGAATCCTGGTCCCCAGCAGGAGAGCCTAGTCCTCCC CCAGCCCCTCCAGCCACCAGGGTGTCCTCTAGGATGCAGCTGCCAGATCCACTCACTCTGCTGCCTCCAGCAGGACCCAAGGCCACTTTC AACTCTTATGGGGTTCTCCACCTGCCCCAGAGCTTCTCAAGGGAGGGTAAGGGGGCACCCTGAGCCCACAGGACCCCTACTTCACAGCTC ACAGGGGCAGGAGGCAGCTCCCCTGCCTCCAGGACCCTGTTGCTATGGTGACACAGCGTTTCTAGGACAGAGGGGCCTCCCAGTCTCCCC CCACCACCCGTGCACGACTTCCTCACCACCCCCAGGTTCCCTGCAGATGTCGTGTGTGTCCTGAGTGTTTCTTTGGTTCTTTGCACGCCA AGTCTCTTGGTTGTACCATGTGACACACCCTGTGCACTGGTCGCTGTCTTCGTGGCTTCCACCCTTGTTAATGATGCTCCTGCCTCTGCC TCCCAGCCCCTCACCCAGCACAGCTCTGCCTGGACTTGGAGAGATGGGAGGCAGACCCCCACCACCATACATGCTGTCTGTGGCCCCTCA GACATTCTGTTTCATCTCCCATTCATCTCCCTCCTCCCACCGTGTCAGTTTTTCTGCCTTTCCCTGCTCTGTTCTTCCCCCTCCTTAGGC CCCAGCCTGGGCCCAGACCCATCCTCCCAGCCAGGTTTCCCTCCAGCAGGCTCCTTCCCTCCCTGTCACCTCCCTCTCACCAACCCGGGG TCTGAGCCCCTCATTCCTGACCGTCCGTGTTCTCAGGAGTGGTTGAGGACACAGGGCCCCAGCCCAGCCCTCTGCACCCCCCAGCCCGGC CATCTGCGCCCCACAGCCCCTTTGGAGCTTTTCTCTTGTCCTCTCACTCCTTCCCAGAAGTTTTTGCACAGAACTTCATTTTGAAAGTGT TTTTCTCATTCTCCATACCTCCCCCAAGCTCTCCTCCAGCCCTTCCCAGGGCTCAGCCCTGCTGTCCTGAGCGTCTCCTGGGCCAGAGAG >In-frame_ENST00000416776_ENST00000320580_TCGA-85-8276-01A_FRMD8_chr11_65167330_+_PACS1_chr11_65977833_length(amino acids)=1102AA_start in transcript=69_stop in transcript=3377 MPLRWRALRPCEMDGTEGSAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLPSLSAHELHRAVREVLQLPDIALDVFALW LVSPLLDEPFLQFRRNVFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPAACDLREKLDSFLP AHLCKRGQSLFAALRGRGARAGPGEQGLLNAYRQVQEVSSDGGCEAALGTHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPV SVAISLEGVHVIDSREKGSKRILRSNEIVLPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEV MQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKV KKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKP FFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKIKSTWIKNQDDSLTETDTLEITDQDMFGDASTSLVVPEKVKTPMKSSKTDLQ GSASPSKVEGVHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAE LLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSSILRFFVKSLANKTSDWLGYMRFLIIPLGSHPVAK YLGSVDSKYSSSFLDSGWRDLFSRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSP STAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKS VFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for FRMD8-PACS1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FRMD8-PACS1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FRMD8-PACS1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PACS1 | C3714756 | Intellectual Disability | 2 | GENOMICS_ENGLAND |
Tgene | PACS1 | C0005586 | Bipolar Disorder | 1 | CTD_human |
Tgene | PACS1 | C0005587 | Depression, Bipolar | 1 | CTD_human |
Tgene | PACS1 | C0013146 | Drug abuse | 1 | CTD_human |
Tgene | PACS1 | C0013170 | Drug habituation | 1 | CTD_human |
Tgene | PACS1 | C0013222 | Drug Use Disorders | 1 | CTD_human |
Tgene | PACS1 | C0024713 | Manic Disorder | 1 | CTD_human |
Tgene | PACS1 | C0028754 | Obesity | 1 | CTD_human |
Tgene | PACS1 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
Tgene | PACS1 | C0038580 | Substance Dependence | 1 | CTD_human |
Tgene | PACS1 | C0038586 | Substance Use Disorders | 1 | CTD_human |
Tgene | PACS1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Tgene | PACS1 | C0338831 | Manic | 1 | CTD_human |
Tgene | PACS1 | C0740858 | Substance abuse problem | 1 | CTD_human |
Tgene | PACS1 | C1510472 | Drug Dependence | 1 | CTD_human |
Tgene | PACS1 | C3554343 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 17 | 1 | GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Tgene | PACS1 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |