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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:FTH1-KRT78 (FusionGDB2 ID:31503)

Fusion Gene Summary for FTH1-KRT78

Fusion gene summary

Fusion gene information	Fusion gene name: FTH1-KRT78
	Fusion gene ID: 31503
		Hgene	Tgene
	Gene symbol	FTH1	KRT78
	Gene ID	2495	196374
	Gene name	ferritin heavy chain 1	keratin 78
	Synonyms	FHC\|FTH\|FTHL6\|HFE5\|PIG15\|PLIF	CK-78\|K5B\|K78\|Kb40
	Cytomap	11q12.3	12q13.13
	Type of gene	protein-coding	protein-coding
	Description	ferritin heavy chainapoferritincell proliferation-inducing gene 15 proteinferritin H subunitferritin, heavy polypeptide 1placenta immunoregulatory factorproliferation-inducing protein 15	keratin, type II cytoskeletal 78cytokeratin-78keratin 78, type IIkeratin-5btype-II keratin Kb40
	Modification date	20200329	20200313
	UniProtAcc	P02794	.
	Ensembl transtripts involved in fusion gene	ENST00000529631, ENST00000529191, ENST00000273550, ENST00000526640, ENST00000532601,	ENST00000359499, ENST00000304620,
Fusion gene scores	* DoF score	29 X 25 X 6=4350	6 X 3 X 5=90
	# samples	49	6
	** MAII score	log2(49/4350*10)=-3.15016174662088 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FTH1 [Title/Abstract] AND KRT78 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	FTH1(61734783)-KRT78(53233768), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FTH1	GO:0006880	intracellular sequestering of iron ion	9924025
Hgene	FTH1	GO:0048147	negative regulation of fibroblast proliferation	9924025

Fusion gene breakpoints across FTH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KRT78 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-IN-AB1X-11A	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-

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Fusion Gene ORF analysis for FTH1-KRT78

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000529631	ENST00000359499	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-
In-frame	ENST00000529631	ENST00000304620	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-
In-frame	ENST00000529191	ENST00000359499	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-
In-frame	ENST00000529191	ENST00000304620	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-
In-frame	ENST00000273550	ENST00000359499	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-
In-frame	ENST00000273550	ENST00000304620	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-
intron-3CDS	ENST00000526640	ENST00000359499	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-
intron-3CDS	ENST00000526640	ENST00000304620	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-
intron-3CDS	ENST00000532601	ENST00000359499	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-
intron-3CDS	ENST00000532601	ENST00000304620	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000529631	FTH1	chr11	61734783	-	ENST00000359499	KRT78	chr12	53233768	-	2145	320	964	254	236
ENST00000529631	FTH1	chr11	61734783	-	ENST00000304620	KRT78	chr12	53233768	-	987	320	964	254	236
ENST00000529191	FTH1	chr11	61734783	-	ENST00000359499	KRT78	chr12	53233768	-	2145	320	964	254	236
ENST00000529191	FTH1	chr11	61734783	-	ENST00000304620	KRT78	chr12	53233768	-	987	320	964	254	236
ENST00000273550	FTH1	chr11	61734783	-	ENST00000359499	KRT78	chr12	53233768	-	2174	349	993	283	236
ENST00000273550	FTH1	chr11	61734783	-	ENST00000304620	KRT78	chr12	53233768	-	1016	349	993	283	236

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000529631	ENST00000359499	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-	0.018062396	0.98193765
ENST00000529631	ENST00000304620	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-	0.005978012	0.99402195
ENST00000529191	ENST00000359499	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-	0.018062396	0.98193765
ENST00000529191	ENST00000304620	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-	0.005978012	0.99402195
ENST00000273550	ENST00000359499	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-	0.024659503	0.9753405
ENST00000273550	ENST00000304620	FTH1	chr11	61734783	-	KRT78	chr12	53233768	-	0.008530438	0.99146956

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Fusion Genomic Features for FTH1-KRT78

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FTH1-KRT78

Go to
FGviewer for the breakpoints of chr11:61734783-chr12:53233768
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FTH1 P02794	.
FUNCTION: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000304620

430_507

349.0

521.0

Compositional bias

Note=Ser-rich

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000359499

430_507

239.0

411.0

Compositional bias

Note=Ser-rich

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000304620

422_520

349.0

521.0

Region

Note=Tail

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000359499

259_281

239.0

411.0

Region

Note=Linker 12

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000359499

282_421

239.0

411.0

Region

Note=Coil 2

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000359499

422_520

239.0

411.0

Region

Note=Tail

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FTH1

chr11:61734783

chr12:53233768

ENST00000273550

11_160

38.0

184.0

Domain

Ferritin-like diiron

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000304620

7_82

349.0

521.0

Compositional bias

Note=Gly-rich

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000359499

7_82

239.0

411.0

Compositional bias

Note=Gly-rich

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000304620

111_424

349.0

521.0

Domain

IF rod

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000359499

111_424

239.0

411.0

Domain

IF rod

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000304620

111_146

349.0

521.0

Region

Note=Coil 1A

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000304620

147_165

349.0

521.0

Region

Note=Linker 1

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000304620

166_258

349.0

521.0

Region

Note=Coil 1B

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000304620

259_281

349.0

521.0

Region

Note=Linker 12

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000304620

282_421

349.0

521.0

Region

Note=Coil 2

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000359499

111_146

239.0

411.0

Region

Note=Coil 1A

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000359499

147_165

239.0

411.0

Region

Note=Linker 1

Tgene

KRT78

chr11:61734783

chr12:53233768

ENST00000359499

166_258

239.0

411.0

Region

Note=Coil 1B

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Fusion Gene Sequence for FTH1-KRT78

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000529631_ENST00000359499_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(transcript)=2145nt_BP=320nt
AGACGTTCTTCGCCGAGAGTCGTCGGGGTTTCCTGCTTCAACAGTGCTTGGACGGAACCCGGCGCTCGTTCCCCACCCCGGCCGGCCGCC
CATAGCCAGCCCTCCGTCACCTCTTCACCGCACCCTCGGACTGCCCCAAGGCCCCCGCCGCCGCTCCAGCGCCGCGCAGCCACCGCCGCC
GCCGCCGCCTCTCCTTAGTCGCCGCCATGACGACCGCGTCCACCTCGCAGGTGCGCCAGAACTACCACCAGGACTCAGAGGCCGCCATCA
ACCGCCAGATCAACCTGGAGCTCTACGCCTCCTACGTTTACCTGTCCATGAACGCCAGCCTGCAGGCCGCCATCACTGATGCTGAGCAGC
GTGGGGAGCTGGCCCTCAAGGACGCTCAGGCCAAGGTGGACGAGCTGGAGGCTGCTCTGAGGATGGCCAAGCAGAACCTGGCCCGGCTGC
TGTGCGAGTACCAGGAGCTGACGAGCACGAAGCTTTCCCTGGATGTGGAGATTGCCACTTACCGCAGGCTGCTGGAGGGCGAGGAGTGCA
GGATGTCTGGGGAGTGCACCAGCCAGGTCACTATCTCCTCGGTGGGAGGCAGCGCTGTCATGTCTGGAGGAGTTGGTGGAGGCTTGGGGA
GCACTTGTGGACTCGGTAGTGGGAAAGGCAGCCCTGGGTCCTGCTGCACCAGCATTGTGACTGGAGGCTCCAACATCATTCTGGGCTCTG
GGAAGGACCCTGTTTTGGATTCCTGCTCTGTGTCTGGCTCCAGCGCTGGCTCCAGCTGCCACACCATCCTGAAGAAGACAGTTGAGTCGA
GTCTGAAGACATCCATCACCTACTGAGCGACCCAGCAGCCACCTCCTTCCTGAACACATTTGGCCCACTCCCCCCATCAGCCGGCTCTGC
AAGGCCAACTCCGTGTCCGCTGCCCACAGCCCAAGCCAGCCCACAGCGGATGCTGCAAAAATCAATAAAGTCTCCCCTCCTGCTGTTCTG
AATGCTCTAAGTGCTTGCACACCTCACCCAGCAAAACAAAAGCTGTGTGGCTCCCCAGCTTCCTCTCCTCGGAAGGCAATTGTGGCATAT
CTGTGTCCAGACGTGTTCTATTGGTATCTCACTCCACATCCCAGCCACTCTATCAAGGGATCCTTCAAGCTCTCCAGTGTGTTCCTTGGG
GTGCCCTCCATCTCCCACAACTCCACTGATGTTTTAGCTGTGCTTGTAGCTCACTTCCTCATCAACTGCCTGTTTTAAGAGGTTCTAGTC
CTGACTGGGGCAGCCCCCTTCCTTCTTGTTCCTCCTTCTTCCTGACTGTGCACCAAAATTTTCTCCTTTTAGGAACCTTCTCTAATTCCC
ATGTCTAAACTACTGGGCCCTTCCTGTCCCTGGCAGTCTGGCTGCACCTGTTGCTGTCCTGGGTGCTATGTCTGTCTGGCTCTGGTAAGG
GACTCAGCTTCTCTATTAGCCTGGCACTCCTGCATCCAGGATGAGGATGTGCTCAGCTTGTGCCTGGGGGCTCTGATGGAGATTGGGGTT
CAAACTCTGCCCCTACCCCCTTATCTGTTGGCTCTCATCTTATCCTTGGGCAAGTGTGAACATGAGGCTGGAAACTTCTCCTCCTTCCTC
TCCTTCAGGAAGCTCTGCAGGAAGCCAGGAGTGTGGGAATCAGGTGGGGTGCCAGGAGGGGCTGGAAGGATCACCTTTTCTACACACCCC
CAGCAGCCTCATGGGTGCCTGCAGTTGCTCTTTCCCCATTCTCGCTTTCCAGACCCAGGTGGGGGACCTGGCTCAACCCCAAACTCCATA
GTCTGGGCTGCAGGAGGTCACACTACGCCTCTCCTTGCTTTAGAGGGAGGGCAGACCTTTCCTCAGATTCATGAATCGCTCCATCCAAAT
TATGCAAGAAGGCTTTTCAGCTTTGTGTGAAGGAGACCAGAGCCGGTGAGGATGTGGCTTGAATCCCAGCTCTGCTGTTTCCTAGTGGTG
TGACCTTGATCAAGCAGCTTGACCTCTTCAGTTACCTCATCTGTAAAAAGAGATTAATAATAATATGTACCTCACAGGGCTGTGTGGCGA

>In-frame_ENST00000529631_ENST00000359499_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(amino acids)=236AA_start in transcript=964_stop in transcript=254
MIFAASAVGWLGLWAADTELALQSRLMGGVGQMCSGRRWLLGRSVGDGCLQTRLNCLLQDGVAAGASAGARHRAGIQNRVLPRAQNDVGA
SSHNAGAAGPRAAFPTTESTSAPQASTNSSRHDSAASHRGDSDLAGALPRHPALLALQQPAVSGNLHIQGKLRARQLLVLAQQPGQVLLG

--------------------------------------------------------------
>In-frame_ENST00000529631_ENST00000304620_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(transcript)=987nt_BP=320nt
AGACGTTCTTCGCCGAGAGTCGTCGGGGTTTCCTGCTTCAACAGTGCTTGGACGGAACCCGGCGCTCGTTCCCCACCCCGGCCGGCCGCC
CATAGCCAGCCCTCCGTCACCTCTTCACCGCACCCTCGGACTGCCCCAAGGCCCCCGCCGCCGCTCCAGCGCCGCGCAGCCACCGCCGCC
GCCGCCGCCTCTCCTTAGTCGCCGCCATGACGACCGCGTCCACCTCGCAGGTGCGCCAGAACTACCACCAGGACTCAGAGGCCGCCATCA
ACCGCCAGATCAACCTGGAGCTCTACGCCTCCTACGTTTACCTGTCCATGAACGCCAGCCTGCAGGCCGCCATCACTGATGCTGAGCAGC
GTGGGGAGCTGGCCCTCAAGGACGCTCAGGCCAAGGTGGACGAGCTGGAGGCTGCTCTGAGGATGGCCAAGCAGAACCTGGCCCGGCTGC
TGTGCGAGTACCAGGAGCTGACGAGCACGAAGCTTTCCCTGGATGTGGAGATTGCCACTTACCGCAGGCTGCTGGAGGGCGAGGAGTGCA
GGATGTCTGGGGAGTGCACCAGCCAGGTCACTATCTCCTCGGTGGGAGGCAGCGCTGTCATGTCTGGAGGAGTTGGTGGAGGCTTGGGGA
GCACTTGTGGACTCGGTAGTGGGAAAGGCAGCCCTGGGTCCTGCTGCACCAGCATTGTGACTGGAGGCTCCAACATCATTCTGGGCTCTG
GGAAGGACCCTGTTTTGGATTCCTGCTCTGTGTCTGGCTCCAGCGCTGGCTCCAGCTGCCACACCATCCTGAAGAAGACAGTTGAGTCGA
GTCTGAAGACATCCATCACCTACTGAGCGACCCAGCAGCCACCTCCTTCCTGAACACATTTGGCCCACTCCCCCCATCAGCCGGCTCTGC

>In-frame_ENST00000529631_ENST00000304620_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(amino acids)=236AA_start in transcript=964_stop in transcript=254
MIFAASAVGWLGLWAADTELALQSRLMGGVGQMCSGRRWLLGRSVGDGCLQTRLNCLLQDGVAAGASAGARHRAGIQNRVLPRAQNDVGA
SSHNAGAAGPRAAFPTTESTSAPQASTNSSRHDSAASHRGDSDLAGALPRHPALLALQQPAVSGNLHIQGKLRARQLLVLAQQPGQVLLG

--------------------------------------------------------------
>In-frame_ENST00000529191_ENST00000359499_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(transcript)=2145nt_BP=320nt
AGACGTTCTTCGCCGAGAGTCGTCGGGGTTTCCTGCTTCAACAGTGCTTGGACGGAACCCGGCGCTCGTTCCCCACCCCGGCCGGCCGCC
CATAGCCAGCCCTCCGTCACCTCTTCACCGCACCCTCGGACTGCCCCAAGGCCCCCGCCGCCGCTCCAGCGCCGCGCAGCCACCGCCGCC
GCCGCCGCCTCTCCTTAGTCGCCGCCATGACGACCGCGTCCACCTCGCAGGTGCGCCAGAACTACCACCAGGACTCAGAGGCCGCCATCA
ACCGCCAGATCAACCTGGAGCTCTACGCCTCCTACGTTTACCTGTCCATGAACGCCAGCCTGCAGGCCGCCATCACTGATGCTGAGCAGC
GTGGGGAGCTGGCCCTCAAGGACGCTCAGGCCAAGGTGGACGAGCTGGAGGCTGCTCTGAGGATGGCCAAGCAGAACCTGGCCCGGCTGC
TGTGCGAGTACCAGGAGCTGACGAGCACGAAGCTTTCCCTGGATGTGGAGATTGCCACTTACCGCAGGCTGCTGGAGGGCGAGGAGTGCA
GGATGTCTGGGGAGTGCACCAGCCAGGTCACTATCTCCTCGGTGGGAGGCAGCGCTGTCATGTCTGGAGGAGTTGGTGGAGGCTTGGGGA
GCACTTGTGGACTCGGTAGTGGGAAAGGCAGCCCTGGGTCCTGCTGCACCAGCATTGTGACTGGAGGCTCCAACATCATTCTGGGCTCTG
GGAAGGACCCTGTTTTGGATTCCTGCTCTGTGTCTGGCTCCAGCGCTGGCTCCAGCTGCCACACCATCCTGAAGAAGACAGTTGAGTCGA
GTCTGAAGACATCCATCACCTACTGAGCGACCCAGCAGCCACCTCCTTCCTGAACACATTTGGCCCACTCCCCCCATCAGCCGGCTCTGC
AAGGCCAACTCCGTGTCCGCTGCCCACAGCCCAAGCCAGCCCACAGCGGATGCTGCAAAAATCAATAAAGTCTCCCCTCCTGCTGTTCTG
AATGCTCTAAGTGCTTGCACACCTCACCCAGCAAAACAAAAGCTGTGTGGCTCCCCAGCTTCCTCTCCTCGGAAGGCAATTGTGGCATAT
CTGTGTCCAGACGTGTTCTATTGGTATCTCACTCCACATCCCAGCCACTCTATCAAGGGATCCTTCAAGCTCTCCAGTGTGTTCCTTGGG
GTGCCCTCCATCTCCCACAACTCCACTGATGTTTTAGCTGTGCTTGTAGCTCACTTCCTCATCAACTGCCTGTTTTAAGAGGTTCTAGTC
CTGACTGGGGCAGCCCCCTTCCTTCTTGTTCCTCCTTCTTCCTGACTGTGCACCAAAATTTTCTCCTTTTAGGAACCTTCTCTAATTCCC
ATGTCTAAACTACTGGGCCCTTCCTGTCCCTGGCAGTCTGGCTGCACCTGTTGCTGTCCTGGGTGCTATGTCTGTCTGGCTCTGGTAAGG
GACTCAGCTTCTCTATTAGCCTGGCACTCCTGCATCCAGGATGAGGATGTGCTCAGCTTGTGCCTGGGGGCTCTGATGGAGATTGGGGTT
CAAACTCTGCCCCTACCCCCTTATCTGTTGGCTCTCATCTTATCCTTGGGCAAGTGTGAACATGAGGCTGGAAACTTCTCCTCCTTCCTC
TCCTTCAGGAAGCTCTGCAGGAAGCCAGGAGTGTGGGAATCAGGTGGGGTGCCAGGAGGGGCTGGAAGGATCACCTTTTCTACACACCCC
CAGCAGCCTCATGGGTGCCTGCAGTTGCTCTTTCCCCATTCTCGCTTTCCAGACCCAGGTGGGGGACCTGGCTCAACCCCAAACTCCATA
GTCTGGGCTGCAGGAGGTCACACTACGCCTCTCCTTGCTTTAGAGGGAGGGCAGACCTTTCCTCAGATTCATGAATCGCTCCATCCAAAT
TATGCAAGAAGGCTTTTCAGCTTTGTGTGAAGGAGACCAGAGCCGGTGAGGATGTGGCTTGAATCCCAGCTCTGCTGTTTCCTAGTGGTG
TGACCTTGATCAAGCAGCTTGACCTCTTCAGTTACCTCATCTGTAAAAAGAGATTAATAATAATATGTACCTCACAGGGCTGTGTGGCGA

>In-frame_ENST00000529191_ENST00000359499_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(amino acids)=236AA_start in transcript=964_stop in transcript=254
MIFAASAVGWLGLWAADTELALQSRLMGGVGQMCSGRRWLLGRSVGDGCLQTRLNCLLQDGVAAGASAGARHRAGIQNRVLPRAQNDVGA
SSHNAGAAGPRAAFPTTESTSAPQASTNSSRHDSAASHRGDSDLAGALPRHPALLALQQPAVSGNLHIQGKLRARQLLVLAQQPGQVLLG

--------------------------------------------------------------
>In-frame_ENST00000529191_ENST00000304620_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(transcript)=987nt_BP=320nt
AGACGTTCTTCGCCGAGAGTCGTCGGGGTTTCCTGCTTCAACAGTGCTTGGACGGAACCCGGCGCTCGTTCCCCACCCCGGCCGGCCGCC
CATAGCCAGCCCTCCGTCACCTCTTCACCGCACCCTCGGACTGCCCCAAGGCCCCCGCCGCCGCTCCAGCGCCGCGCAGCCACCGCCGCC
GCCGCCGCCTCTCCTTAGTCGCCGCCATGACGACCGCGTCCACCTCGCAGGTGCGCCAGAACTACCACCAGGACTCAGAGGCCGCCATCA
ACCGCCAGATCAACCTGGAGCTCTACGCCTCCTACGTTTACCTGTCCATGAACGCCAGCCTGCAGGCCGCCATCACTGATGCTGAGCAGC
GTGGGGAGCTGGCCCTCAAGGACGCTCAGGCCAAGGTGGACGAGCTGGAGGCTGCTCTGAGGATGGCCAAGCAGAACCTGGCCCGGCTGC
TGTGCGAGTACCAGGAGCTGACGAGCACGAAGCTTTCCCTGGATGTGGAGATTGCCACTTACCGCAGGCTGCTGGAGGGCGAGGAGTGCA
GGATGTCTGGGGAGTGCACCAGCCAGGTCACTATCTCCTCGGTGGGAGGCAGCGCTGTCATGTCTGGAGGAGTTGGTGGAGGCTTGGGGA
GCACTTGTGGACTCGGTAGTGGGAAAGGCAGCCCTGGGTCCTGCTGCACCAGCATTGTGACTGGAGGCTCCAACATCATTCTGGGCTCTG
GGAAGGACCCTGTTTTGGATTCCTGCTCTGTGTCTGGCTCCAGCGCTGGCTCCAGCTGCCACACCATCCTGAAGAAGACAGTTGAGTCGA
GTCTGAAGACATCCATCACCTACTGAGCGACCCAGCAGCCACCTCCTTCCTGAACACATTTGGCCCACTCCCCCCATCAGCCGGCTCTGC

>In-frame_ENST00000529191_ENST00000304620_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(amino acids)=236AA_start in transcript=964_stop in transcript=254
MIFAASAVGWLGLWAADTELALQSRLMGGVGQMCSGRRWLLGRSVGDGCLQTRLNCLLQDGVAAGASAGARHRAGIQNRVLPRAQNDVGA
SSHNAGAAGPRAAFPTTESTSAPQASTNSSRHDSAASHRGDSDLAGALPRHPALLALQQPAVSGNLHIQGKLRARQLLVLAQQPGQVLLG

--------------------------------------------------------------
>In-frame_ENST00000273550_ENST00000359499_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(transcript)=2174nt_BP=349nt
ATAAGAGACCACAAGCGACCCGCAGGGCCAGACGTTCTTCGCCGAGAGTCGTCGGGGTTTCCTGCTTCAACAGTGCTTGGACGGAACCCG
GCGCTCGTTCCCCACCCCGGCCGGCCGCCCATAGCCAGCCCTCCGTCACCTCTTCACCGCACCCTCGGACTGCCCCAAGGCCCCCGCCGC
CGCTCCAGCGCCGCGCAGCCACCGCCGCCGCCGCCGCCTCTCCTTAGTCGCCGCCATGACGACCGCGTCCACCTCGCAGGTGCGCCAGAA
CTACCACCAGGACTCAGAGGCCGCCATCAACCGCCAGATCAACCTGGAGCTCTACGCCTCCTACGTTTACCTGTCCATGAACGCCAGCCT
GCAGGCCGCCATCACTGATGCTGAGCAGCGTGGGGAGCTGGCCCTCAAGGACGCTCAGGCCAAGGTGGACGAGCTGGAGGCTGCTCTGAG
GATGGCCAAGCAGAACCTGGCCCGGCTGCTGTGCGAGTACCAGGAGCTGACGAGCACGAAGCTTTCCCTGGATGTGGAGATTGCCACTTA
CCGCAGGCTGCTGGAGGGCGAGGAGTGCAGGATGTCTGGGGAGTGCACCAGCCAGGTCACTATCTCCTCGGTGGGAGGCAGCGCTGTCAT
GTCTGGAGGAGTTGGTGGAGGCTTGGGGAGCACTTGTGGACTCGGTAGTGGGAAAGGCAGCCCTGGGTCCTGCTGCACCAGCATTGTGAC
TGGAGGCTCCAACATCATTCTGGGCTCTGGGAAGGACCCTGTTTTGGATTCCTGCTCTGTGTCTGGCTCCAGCGCTGGCTCCAGCTGCCA
CACCATCCTGAAGAAGACAGTTGAGTCGAGTCTGAAGACATCCATCACCTACTGAGCGACCCAGCAGCCACCTCCTTCCTGAACACATTT
GGCCCACTCCCCCCATCAGCCGGCTCTGCAAGGCCAACTCCGTGTCCGCTGCCCACAGCCCAAGCCAGCCCACAGCGGATGCTGCAAAAA
TCAATAAAGTCTCCCCTCCTGCTGTTCTGAATGCTCTAAGTGCTTGCACACCTCACCCAGCAAAACAAAAGCTGTGTGGCTCCCCAGCTT
CCTCTCCTCGGAAGGCAATTGTGGCATATCTGTGTCCAGACGTGTTCTATTGGTATCTCACTCCACATCCCAGCCACTCTATCAAGGGAT
CCTTCAAGCTCTCCAGTGTGTTCCTTGGGGTGCCCTCCATCTCCCACAACTCCACTGATGTTTTAGCTGTGCTTGTAGCTCACTTCCTCA
TCAACTGCCTGTTTTAAGAGGTTCTAGTCCTGACTGGGGCAGCCCCCTTCCTTCTTGTTCCTCCTTCTTCCTGACTGTGCACCAAAATTT
TCTCCTTTTAGGAACCTTCTCTAATTCCCATGTCTAAACTACTGGGCCCTTCCTGTCCCTGGCAGTCTGGCTGCACCTGTTGCTGTCCTG
GGTGCTATGTCTGTCTGGCTCTGGTAAGGGACTCAGCTTCTCTATTAGCCTGGCACTCCTGCATCCAGGATGAGGATGTGCTCAGCTTGT
GCCTGGGGGCTCTGATGGAGATTGGGGTTCAAACTCTGCCCCTACCCCCTTATCTGTTGGCTCTCATCTTATCCTTGGGCAAGTGTGAAC
ATGAGGCTGGAAACTTCTCCTCCTTCCTCTCCTTCAGGAAGCTCTGCAGGAAGCCAGGAGTGTGGGAATCAGGTGGGGTGCCAGGAGGGG
CTGGAAGGATCACCTTTTCTACACACCCCCAGCAGCCTCATGGGTGCCTGCAGTTGCTCTTTCCCCATTCTCGCTTTCCAGACCCAGGTG
GGGGACCTGGCTCAACCCCAAACTCCATAGTCTGGGCTGCAGGAGGTCACACTACGCCTCTCCTTGCTTTAGAGGGAGGGCAGACCTTTC
CTCAGATTCATGAATCGCTCCATCCAAATTATGCAAGAAGGCTTTTCAGCTTTGTGTGAAGGAGACCAGAGCCGGTGAGGATGTGGCTTG
AATCCCAGCTCTGCTGTTTCCTAGTGGTGTGACCTTGATCAAGCAGCTTGACCTCTTCAGTTACCTCATCTGTAAAAAGAGATTAATAAT
AATATGTACCTCACAGGGCTGTGTGGCGACAGTGCCACTAGGATCCCAGAAGGAAACTAAATTCATCCAAGGTAGTTCAATTAAATTGAC

>In-frame_ENST00000273550_ENST00000359499_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(amino acids)=236AA_start in transcript=993_stop in transcript=283
MIFAASAVGWLGLWAADTELALQSRLMGGVGQMCSGRRWLLGRSVGDGCLQTRLNCLLQDGVAAGASAGARHRAGIQNRVLPRAQNDVGA
SSHNAGAAGPRAAFPTTESTSAPQASTNSSRHDSAASHRGDSDLAGALPRHPALLALQQPAVSGNLHIQGKLRARQLLVLAQQPGQVLLG

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>In-frame_ENST00000273550_ENST00000304620_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(transcript)=1016nt_BP=349nt
ATAAGAGACCACAAGCGACCCGCAGGGCCAGACGTTCTTCGCCGAGAGTCGTCGGGGTTTCCTGCTTCAACAGTGCTTGGACGGAACCCG
GCGCTCGTTCCCCACCCCGGCCGGCCGCCCATAGCCAGCCCTCCGTCACCTCTTCACCGCACCCTCGGACTGCCCCAAGGCCCCCGCCGC
CGCTCCAGCGCCGCGCAGCCACCGCCGCCGCCGCCGCCTCTCCTTAGTCGCCGCCATGACGACCGCGTCCACCTCGCAGGTGCGCCAGAA
CTACCACCAGGACTCAGAGGCCGCCATCAACCGCCAGATCAACCTGGAGCTCTACGCCTCCTACGTTTACCTGTCCATGAACGCCAGCCT
GCAGGCCGCCATCACTGATGCTGAGCAGCGTGGGGAGCTGGCCCTCAAGGACGCTCAGGCCAAGGTGGACGAGCTGGAGGCTGCTCTGAG
GATGGCCAAGCAGAACCTGGCCCGGCTGCTGTGCGAGTACCAGGAGCTGACGAGCACGAAGCTTTCCCTGGATGTGGAGATTGCCACTTA
CCGCAGGCTGCTGGAGGGCGAGGAGTGCAGGATGTCTGGGGAGTGCACCAGCCAGGTCACTATCTCCTCGGTGGGAGGCAGCGCTGTCAT
GTCTGGAGGAGTTGGTGGAGGCTTGGGGAGCACTTGTGGACTCGGTAGTGGGAAAGGCAGCCCTGGGTCCTGCTGCACCAGCATTGTGAC
TGGAGGCTCCAACATCATTCTGGGCTCTGGGAAGGACCCTGTTTTGGATTCCTGCTCTGTGTCTGGCTCCAGCGCTGGCTCCAGCTGCCA
CACCATCCTGAAGAAGACAGTTGAGTCGAGTCTGAAGACATCCATCACCTACTGAGCGACCCAGCAGCCACCTCCTTCCTGAACACATTT
GGCCCACTCCCCCCATCAGCCGGCTCTGCAAGGCCAACTCCGTGTCCGCTGCCCACAGCCCAAGCCAGCCCACAGCGGATGCTGCAAAAA

>In-frame_ENST00000273550_ENST00000304620_TCGA-IN-AB1X-11A_FTH1_chr11_61734783_-_KRT78_chr12_53233768_length(amino acids)=236AA_start in transcript=993_stop in transcript=283
MIFAASAVGWLGLWAADTELALQSRLMGGVGQMCSGRRWLLGRSVGDGCLQTRLNCLLQDGVAAGASAGARHRAGIQNRVLPRAQNDVGA
SSHNAGAAGPRAAFPTTESTSAPQASTNSSRHDSAASHRGDSDLAGALPRHPALLALQQPAVSGNLHIQGKLRARQLLVLAQQPGQVLLG

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Fusion Gene PPI Analysis for FTH1-KRT78

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for FTH1-KRT78

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	FTH1	P02794	DB01592	Iron		Small molecule	Approved
Hgene	FTH1	P02794	DB01592	Iron		Small molecule	Approved
Hgene	FTH1	P02794	DB01592	Iron		Small molecule	Approved
Hgene	FTH1	P02794	DB01592	Iron		Small molecule	Approved
Hgene	FTH1	P02794	DB01592	Iron		Small molecule	Approved
Hgene	FTH1	P02794	DB14488	Ferrous gluconate		Small molecule	Approved
Hgene	FTH1	P02794	DB14488	Ferrous gluconate		Small molecule	Approved
Hgene	FTH1	P02794	DB14488	Ferrous gluconate		Small molecule	Approved
Hgene	FTH1	P02794	DB14488	Ferrous gluconate		Small molecule	Approved
Hgene	FTH1	P02794	DB14488	Ferrous gluconate		Small molecule	Approved
Hgene	FTH1	P02794	DB14489	Ferrous succinate		Small molecule	Approved
Hgene	FTH1	P02794	DB14489	Ferrous succinate		Small molecule	Approved
Hgene	FTH1	P02794	DB14489	Ferrous succinate		Small molecule	Approved
Hgene	FTH1	P02794	DB14489	Ferrous succinate		Small molecule	Approved
Hgene	FTH1	P02794	DB14489	Ferrous succinate		Small molecule	Approved
Hgene	FTH1	P02794	DB14490	Ferrous ascorbate		Small molecule	Approved
Hgene	FTH1	P02794	DB14490	Ferrous ascorbate		Small molecule	Approved
Hgene	FTH1	P02794	DB14490	Ferrous ascorbate		Small molecule	Approved
Hgene	FTH1	P02794	DB14490	Ferrous ascorbate		Small molecule	Approved
Hgene	FTH1	P02794	DB14490	Ferrous ascorbate		Small molecule	Approved
Hgene	FTH1	P02794	DB14491	Ferrous fumarate		Small molecule	Approved
Hgene	FTH1	P02794	DB14491	Ferrous fumarate		Small molecule	Approved
Hgene	FTH1	P02794	DB14491	Ferrous fumarate		Small molecule	Approved
Hgene	FTH1	P02794	DB14491	Ferrous fumarate		Small molecule	Approved
Hgene	FTH1	P02794	DB14491	Ferrous fumarate		Small molecule	Approved
Hgene	FTH1	P02794	DB14501	Ferrous glycine sulfate		Small molecule	Approved
Hgene	FTH1	P02794	DB14501	Ferrous glycine sulfate		Small molecule	Approved
Hgene	FTH1	P02794	DB14501	Ferrous glycine sulfate		Small molecule	Approved
Hgene	FTH1	P02794	DB14501	Ferrous glycine sulfate		Small molecule	Approved
Hgene	FTH1	P02794	DB14501	Ferrous glycine sulfate		Small molecule	Approved
Hgene	FTH1	P02794	DB13995	Ferric pyrophosphate citrate	Binder	Small molecule	Approved\|Investigational
Hgene	FTH1	P02794	DB13995	Ferric pyrophosphate citrate	Binder	Small molecule	Approved\|Investigational
Hgene	FTH1	P02794	DB13995	Ferric pyrophosphate citrate	Binder	Small molecule	Approved\|Investigational
Hgene	FTH1	P02794	DB13995	Ferric pyrophosphate citrate	Binder	Small molecule	Approved\|Investigational
Hgene	FTH1	P02794	DB13995	Ferric pyrophosphate citrate	Binder	Small molecule	Approved\|Investigational
Hgene	FTH1	P02794	DB00893	Iron Dextran	Other	Small molecule	Approved\|Vet_approved
Hgene	FTH1	P02794	DB00893	Iron Dextran	Other	Small molecule	Approved\|Vet_approved
Hgene	FTH1	P02794	DB00893	Iron Dextran	Other	Small molecule	Approved\|Vet_approved
Hgene	FTH1	P02794	DB00893	Iron Dextran	Other	Small molecule	Approved\|Vet_approved
Hgene	FTH1	P02794	DB00893	Iron Dextran	Other	Small molecule	Approved\|Vet_approved

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Related Diseases for FTH1-KRT78

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FTH1	C0011573	Endogenous depression	1	CTD_human
Hgene	FTH1	C0011581	Depressive disorder	1	CTD_human
Hgene	FTH1	C0011616	Contact Dermatitis	1	CTD_human
Hgene	FTH1	C0017638	Glioma	1	CTD_human
Hgene	FTH1	C0022548	Keloid	1	CTD_human
Hgene	FTH1	C0025193	Melancholia	1	CTD_human
Hgene	FTH1	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	FTH1	C0032927	Precancerous Conditions	1	CTD_human
Hgene	FTH1	C0041696	Unipolar Depression	1	CTD_human
Hgene	FTH1	C0086133	Depressive Syndrome	1	CTD_human
Hgene	FTH1	C0162351	Contact hypersensitivity	1	CTD_human
Hgene	FTH1	C0259783	mixed gliomas	1	CTD_human
Hgene	FTH1	C0270715	Degenerative Diseases, Central Nervous System	1	CTD_human
Hgene	FTH1	C0282126	Depression, Neurotic	1	CTD_human
Hgene	FTH1	C0282193	Iron Overload	1	CTD_human
Hgene	FTH1	C0282313	Condition, Preneoplastic	1	CTD_human
Hgene	FTH1	C0345967	Malignant mesothelioma	1	CTD_human
Hgene	FTH1	C0524851	Neurodegenerative Disorders	1	CTD_human
Hgene	FTH1	C0555198	Malignant Glioma	1	CTD_human
Hgene	FTH1	C0751733	Degenerative Diseases, Spinal Cord	1	CTD_human
Hgene	FTH1	C1851316	Iron Overload, Autosomal Dominant	1	CTD_human;GENOMICS_ENGLAND;ORPHANET