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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:AHCYL1-DENND2D (FusionGDB2 ID:3165) |
Fusion Gene Summary for AHCYL1-DENND2D |
Fusion gene summary |
Fusion gene information | Fusion gene name: AHCYL1-DENND2D | Fusion gene ID: 3165 | Hgene | Tgene | Gene symbol | AHCYL1 | DENND2D | Gene ID | 10768 | 79961 |
Gene name | adenosylhomocysteinase like 1 | DENN domain containing 2D | |
Synonyms | DCAL|IRBIT|PPP1R78|PRO0233|XPVKONA | - | |
Cytomap | 1p13.3 | 1p13.3-p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like moleculeIP(3)Rs binding protein released with IP(3)S-adenosyl homocysteine hydrolase homologS-adenosyl-L-homocysteine hydrolase 2adenosylhomocysteinase 2adoHcyase 2dendritic cell | DENN domain-containing protein 2DDENN/MADD domain containing 2DRP5-1180E21.2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | O43865 | Q9H6A0 | |
Ensembl transtripts involved in fusion gene | ENST00000369799, ENST00000475081, ENST00000359172, ENST00000393614, | ENST00000357640, ENST00000369752, ENST00000473682, | |
Fusion gene scores | * DoF score | 12 X 9 X 4=432 | 3 X 3 X 2=18 |
# samples | 14 | 3 | |
** MAII score | log2(14/432*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: AHCYL1 [Title/Abstract] AND DENND2D [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | AHCYL1(110527794)-DENND2D(111737348), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AHCYL1 | GO:0006378 | mRNA polyadenylation | 19224921 |
Hgene | AHCYL1 | GO:0031440 | regulation of mRNA 3'-end processing | 19224921 |
Hgene | AHCYL1 | GO:0038166 | angiotensin-activated signaling pathway | 20584908 |
Hgene | AHCYL1 | GO:0051592 | response to calcium ion | 18829453 |
Fusion gene breakpoints across AHCYL1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across DENND2D (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-E9-A5FK-01A | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
ChimerDB4 | BRCA | TCGA-E9-A5FK-01A | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
ChimerDB4 | BRCA | TCGA-E9-A5FK-01A | AHCYL1 | chr1 | 110527794 | - | DENND2D | chr1 | 111737348 | - |
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Fusion Gene ORF analysis for AHCYL1-DENND2D |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000369799 | ENST00000357640 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
In-frame | ENST00000369799 | ENST00000369752 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
5CDS-intron | ENST00000369799 | ENST00000473682 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
3UTR-3CDS | ENST00000475081 | ENST00000357640 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
3UTR-3CDS | ENST00000475081 | ENST00000369752 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
3UTR-intron | ENST00000475081 | ENST00000473682 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
intron-3CDS | ENST00000359172 | ENST00000357640 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
intron-3CDS | ENST00000359172 | ENST00000369752 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
intron-intron | ENST00000359172 | ENST00000473682 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
intron-3CDS | ENST00000393614 | ENST00000357640 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
intron-3CDS | ENST00000393614 | ENST00000369752 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
intron-intron | ENST00000393614 | ENST00000473682 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000369799 | AHCYL1 | chr1 | 110527794 | + | ENST00000357640 | DENND2D | chr1 | 111737348 | - | 1689 | 487 | 40 | 1257 | 405 |
ENST00000369799 | AHCYL1 | chr1 | 110527794 | + | ENST00000369752 | DENND2D | chr1 | 111737348 | - | 1689 | 487 | 40 | 1257 | 405 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000369799 | ENST00000357640 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - | 0.005534144 | 0.9944659 |
ENST00000369799 | ENST00000369752 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - | 0.005534144 | 0.9944659 |
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Fusion Genomic Features for AHCYL1-DENND2D |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for AHCYL1-DENND2D |
Go to FGviewer for the breakpoints of chr1:110527794-chr1:111737348 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
AHCYL1 | DENND2D |
FUNCTION: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1, ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548, ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921, ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103, ECO:0000269|PubMed:27995898}. | FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | DENND2D | chr1:110527794 | chr1:111737348 | ENST00000357640 | 5 | 12 | 226_359 | 215.0 | 472.0 | Domain | cDENN | |
Tgene | DENND2D | chr1:110527794 | chr1:111737348 | ENST00000357640 | 5 | 12 | 361_445 | 215.0 | 472.0 | Domain | dDENN | |
Tgene | DENND2D | chr1:110527794 | chr1:111737348 | ENST00000369752 | 5 | 12 | 226_359 | 212.0 | 469.0 | Domain | cDENN | |
Tgene | DENND2D | chr1:110527794 | chr1:111737348 | ENST00000369752 | 5 | 12 | 361_445 | 212.0 | 469.0 | Domain | dDENN |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 318_322 | 0 | 484.0 | Nucleotide binding | NAD |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 397_399 | 0 | 484.0 | Nucleotide binding | NAD |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 318_322 | 40.0 | 531.0 | Nucleotide binding | NAD |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 397_399 | 40.0 | 531.0 | Nucleotide binding | NAD |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 318_322 | 0 | 484.0 | Nucleotide binding | NAD |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 397_399 | 0 | 484.0 | Nucleotide binding | NAD |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 281_448 | 0 | 484.0 | Region | NAD binding |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 520_530 | 0 | 484.0 | Region | PDZ-binding |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 65_92 | 0 | 484.0 | Region | PEST |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 281_448 | 40.0 | 531.0 | Region | NAD binding |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 520_530 | 40.0 | 531.0 | Region | PDZ-binding |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 65_92 | 40.0 | 531.0 | Region | PEST |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 281_448 | 0 | 484.0 | Region | NAD binding |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 520_530 | 0 | 484.0 | Region | PDZ-binding |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 65_92 | 0 | 484.0 | Region | PEST |
Tgene | DENND2D | chr1:110527794 | chr1:111737348 | ENST00000357640 | 5 | 12 | 55_204 | 215.0 | 472.0 | Domain | uDENN | |
Tgene | DENND2D | chr1:110527794 | chr1:111737348 | ENST00000369752 | 5 | 12 | 55_204 | 212.0 | 469.0 | Domain | uDENN |
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Fusion Gene Sequence for AHCYL1-DENND2D |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000369799_ENST00000357640_TCGA-E9-A5FK-01A_AHCYL1_chr1_110527794_+_DENND2D_chr1_111737348_length(transcript)=1689nt_BP=487nt CAGAGTGCCCTTTCTCCCCGCCTCTTCCCCCTCCCGGGAGCTGCCAGTACTTGACGTGGCGTCACCGCCCTCTACCCTCGCTTTGCGTGC GTGTTTGCGTACAGCGGAGGTGGCGGCGCGGGCAGGTCGGAGCTCGGAGCTGCTGTTCTGGTTCTCTTGTGGCCGCCGTCGCTGTCCGGC TGCCTTGGGCTGCCGAACAGACAAGGCGTGGGCCACAGCACCTCAGAAGCCGACGCAGCTCGACGCAGGGGCCGGCAGGAGGGTGGGCGA TCGCGTGTCGGAGGGCGCCGCGCGGGCAGGCGGGCGGGCGCCAGAGGGGGAAAGAGGCGGGGGCGGCGGGTCAGCCGCTGGCCGGGCCGG CCGGGGAATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTA CTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAGTTCATTTCACTGACACGGCCCCTGGACTCCCACCTAGAACATGTGGATTTTAG TTCTCTATTGCACTGTCTCAGTTTTGAACAGATACTTCAGATCTTTGCCTCTGCCGTGCTGGAGAGAAAAATCATCTTCCTGGCGGAAGG TCTCAGCACCTTGTCTCAGTGCATCCATGCTGCTGCCGCACTGCTCTACCCCTTCAGCTGGGCGCACACCTACATCCCTGTTGTCCCTGA GAGCCTTCTGGCCACCGTCTGCTGCCCCACCCCCTTCATGGTTGGAGTACAAATGCGCTTCCAGCAGGAGGTCATGGACAGCCCTATGGA AGAGGTCCTGCTGGTCAATCTTTGTGAAGGAACCTTCTTAATGTCGGTTGGTGATGAAAAAGACATCCTGCCACCGAAGCTTCAGGATGA CATCTTAGACTCTCTTGGTCAGGGGATCAATGAGTTAAAGACTGCAGAACAAATCAACGAGCATGTTTCAGGCCCCTTTGTGCAGTTCTT TGTCAAGATTGTGGGCCATTATGCTTCCTATATCAAGCGGGAGGCAAATGGGCAAGGCCACTTCCAAGAAAGATCCTTCTGTAAGGCTCT GACCTCCAAGACCAACCGCCGATTTGTGAAGAAGTTTGTGAAGACACAGCTCTTCTCACTTTTCATCCAGGAAGCCGAGAAGAGCAAGAA TCCTCCTGCAGGCTATTTCCAACAGAAAATACTTGAATATGAGGAACAGAAGAAACAGAAGAAACCAAGGGAAAAAACTGTGAAATAAGA GCTGTGGTGAATAAGAATGACTAGAGCTACACACCATTTCTGGACTTCAGCCCCTGCCAGTGTGGCAGGATCAGCAAAACTGTCAGCTCC CAAAATCCATATCCTCACTCTGAGTCTTGGTATCCAGGTATTGCTTCAAACTGGTGTCTGAGATTTGGATCCCTGGTATTGATTTCTCAG GACTTTGGAGGGCTCTGACACCATGCTCACAGAACTGGGCTCAGAGCTCCATTTTTTGCAGAGGTGACACAGGTAGGAAACAGTAGTACA TGTGTTGTAGACACTTGGTTAGAAGCTGCTGCAACTGCCCTCTCCCATCATTATAACATCTTCAACACAGAACACACTTTGTGGTCGAAA >In-frame_ENST00000369799_ENST00000357640_TCGA-E9-A5FK-01A_AHCYL1_chr1_110527794_+_DENND2D_chr1_111737348_length(amino acids)=405AA_start in transcript=40_stop in transcript=1257 MPVLDVASPPSTLALRACLRTAEVAARAGRSSELLFWFSCGRRRCPAALGCRTDKAWATAPQKPTQLDAGAGRRVGDRVSEGAARAGGRA PEGERGGGGGSAAGRAGRGMSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKFISLTRPLDSHLEHVDFSSLLHCLSFEQILQ IFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFL MSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFV -------------------------------------------------------------- >In-frame_ENST00000369799_ENST00000369752_TCGA-E9-A5FK-01A_AHCYL1_chr1_110527794_+_DENND2D_chr1_111737348_length(transcript)=1689nt_BP=487nt CAGAGTGCCCTTTCTCCCCGCCTCTTCCCCCTCCCGGGAGCTGCCAGTACTTGACGTGGCGTCACCGCCCTCTACCCTCGCTTTGCGTGC GTGTTTGCGTACAGCGGAGGTGGCGGCGCGGGCAGGTCGGAGCTCGGAGCTGCTGTTCTGGTTCTCTTGTGGCCGCCGTCGCTGTCCGGC TGCCTTGGGCTGCCGAACAGACAAGGCGTGGGCCACAGCACCTCAGAAGCCGACGCAGCTCGACGCAGGGGCCGGCAGGAGGGTGGGCGA TCGCGTGTCGGAGGGCGCCGCGCGGGCAGGCGGGCGGGCGCCAGAGGGGGAAAGAGGCGGGGGCGGCGGGTCAGCCGCTGGCCGGGCCGG CCGGGGAATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTA CTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAGTTCATTTCACTGACACGGCCCCTGGACTCCCACCTAGAACATGTGGATTTTAG TTCTCTATTGCACTGTCTCAGTTTTGAACAGATACTTCAGATCTTTGCCTCTGCCGTGCTGGAGAGAAAAATCATCTTCCTGGCGGAAGG TCTCAGCACCTTGTCTCAGTGCATCCATGCTGCTGCCGCACTGCTCTACCCCTTCAGCTGGGCGCACACCTACATCCCTGTTGTCCCTGA GAGCCTTCTGGCCACCGTCTGCTGCCCCACCCCCTTCATGGTTGGAGTACAAATGCGCTTCCAGCAGGAGGTCATGGACAGCCCTATGGA AGAGGTCCTGCTGGTCAATCTTTGTGAAGGAACCTTCTTAATGTCGGTTGGTGATGAAAAAGACATCCTGCCACCGAAGCTTCAGGATGA CATCTTAGACTCTCTTGGTCAGGGGATCAATGAGTTAAAGACTGCAGAACAAATCAACGAGCATGTTTCAGGCCCCTTTGTGCAGTTCTT TGTCAAGATTGTGGGCCATTATGCTTCCTATATCAAGCGGGAGGCAAATGGGCAAGGCCACTTCCAAGAAAGATCCTTCTGTAAGGCTCT GACCTCCAAGACCAACCGCCGATTTGTGAAGAAGTTTGTGAAGACACAGCTCTTCTCACTTTTCATCCAGGAAGCCGAGAAGAGCAAGAA TCCTCCTGCAGGCTATTTCCAACAGAAAATACTTGAATATGAGGAACAGAAGAAACAGAAGAAACCAAGGGAAAAAACTGTGAAATAAGA GCTGTGGTGAATAAGAATGACTAGAGCTACACACCATTTCTGGACTTCAGCCCCTGCCAGTGTGGCAGGATCAGCAAAACTGTCAGCTCC CAAAATCCATATCCTCACTCTGAGTCTTGGTATCCAGGTATTGCTTCAAACTGGTGTCTGAGATTTGGATCCCTGGTATTGATTTCTCAG GACTTTGGAGGGCTCTGACACCATGCTCACAGAACTGGGCTCAGAGCTCCATTTTTTGCAGAGGTGACACAGGTAGGAAACAGTAGTACA TGTGTTGTAGACACTTGGTTAGAAGCTGCTGCAACTGCCCTCTCCCATCATTATAACATCTTCAACACAGAACACACTTTGTGGTCGAAA >In-frame_ENST00000369799_ENST00000369752_TCGA-E9-A5FK-01A_AHCYL1_chr1_110527794_+_DENND2D_chr1_111737348_length(amino acids)=405AA_start in transcript=40_stop in transcript=1257 MPVLDVASPPSTLALRACLRTAEVAARAGRSSELLFWFSCGRRRCPAALGCRTDKAWATAPQKPTQLDAGAGRRVGDRVSEGAARAGGRA PEGERGGGGGSAAGRAGRGMSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKFISLTRPLDSHLEHVDFSSLLHCLSFEQILQ IFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFL MSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for AHCYL1-DENND2D |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 138_201 | 0 | 484.0 | BCL2L10 |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 138_201 | 40.0 | 531.0 | BCL2L10 |
Hgene | AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 138_201 | 0 | 484.0 | BCL2L10 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AHCYL1-DENND2D |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AHCYL1-DENND2D |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |