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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FUK-DNMT3B (FusionGDB2 ID:31664)

Fusion Gene Summary for FUK-DNMT3B

check button Fusion gene summary
Fusion gene informationFusion gene name: FUK-DNMT3B
Fusion gene ID: 31664
HgeneTgene
Gene symbol

FUK

DNMT3B

Gene ID

197258

1789

Gene namefucose kinaseDNA methyltransferase 3 beta
Synonyms1110046B12Rik|CDGF2|FUKICF|ICF1|M.HsaIIIB
Cytomap

16q22.1

20q11.21

Type of geneprotein-codingprotein-coding
DescriptionL-fucose kinasefucokinaseDNA (cytosine-5)-methyltransferase 3BDNA (cytosine-5-)-methyltransferase 3 betaDNA MTase HsaIIIBDNA cytosine-5--methyltransferase 3 betaDNA methyltransferase HsaIIIB
Modification date2020031320200313
UniProtAcc.

Q9UBC3

Ensembl transtripts involved in fusion geneENST00000288078, ENST00000428974, 
ENST00000571514, ENST00000378912, 
ENST00000328111, ENST00000348286, 
ENST00000353855, ENST00000443239, 
ENST00000344505, ENST00000375623, 
ENST00000456297, ENST00000201963, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 2 X 1=4
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: FUK [Title/Abstract] AND DNMT3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFUK(70497624)-DNMT3B(31390240), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNMT3B

GO:0000122

negative regulation of transcription by RNA polymerase II

17303076


check buttonFusion gene breakpoints across FUK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DNMT3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADB451208FUKchr16

70497624

+DNMT3Bchr20

31390240

+


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Fusion Gene ORF analysis for FUK-DNMT3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000288078ENST00000328111FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000288078ENST00000348286FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000288078ENST00000353855FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000288078ENST00000443239FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000288078ENST00000344505FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000288078ENST00000375623FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000288078ENST00000456297FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000288078ENST00000201963FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000328111FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000348286FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000353855FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000443239FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000428974ENST00000344505FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000428974ENST00000375623FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000428974ENST00000456297FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000428974ENST00000201963FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000328111FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000348286FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000353855FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000443239FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-3CDSENST00000571514ENST00000344505FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-intronENST00000571514ENST00000375623FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-intronENST00000571514ENST00000456297FUKchr16

70497624

+DNMT3Bchr20

31390240

+
intron-intronENST00000571514ENST00000201963FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000328111FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000348286FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000353855FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000443239FUKchr16

70497624

+DNMT3Bchr20

31390240

+
In-frameENST00000378912ENST00000344505FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000378912ENST00000375623FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000378912ENST00000456297FUKchr16

70497624

+DNMT3Bchr20

31390240

+
5CDS-intronENST00000378912ENST00000201963FUKchr16

70497624

+DNMT3Bchr20

31390240

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000288078FUKchr1670497624+ENST00000328111DNMT3Bchr2031390240+2187367829473118
ENST00000288078FUKchr1670497624+ENST00000348286DNMT3Bchr2031390240+1998367223540105
ENST00000288078FUKchr1670497624+ENST00000353855DNMT3Bchr2031390240+2187367829473118
ENST00000288078FUKchr1670497624+ENST00000443239DNMT3Bchr2031390240+922367223540105
ENST00000288078FUKchr1670497624+ENST00000344505DNMT3Bchr2031390240+2067367710306134
ENST00000428974FUKchr1670497624+ENST00000328111DNMT3Bchr2031390240+2013193655299118
ENST00000428974FUKchr1670497624+ENST00000348286DNMT3Bchr2031390240+182419349366105
ENST00000428974FUKchr1670497624+ENST00000353855DNMT3Bchr2031390240+2013193655299118
ENST00000428974FUKchr1670497624+ENST00000443239DNMT3Bchr2031390240+74819349366105
ENST00000428974FUKchr1670497624+ENST00000344505DNMT3Bchr2031390240+1893193536132134
ENST00000378912FUKchr1670497624+ENST00000328111DNMT3Bchr2031390240+2013193655299118
ENST00000378912FUKchr1670497624+ENST00000348286DNMT3Bchr2031390240+182419349366105
ENST00000378912FUKchr1670497624+ENST00000353855DNMT3Bchr2031390240+2013193655299118
ENST00000378912FUKchr1670497624+ENST00000443239DNMT3Bchr2031390240+74819349366105
ENST00000378912FUKchr1670497624+ENST00000344505DNMT3Bchr2031390240+1893193536132134

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000288078ENST00000328111FUKchr1670497624+DNMT3Bchr2031390240+0.0831223350.9168776
ENST00000288078ENST00000348286FUKchr1670497624+DNMT3Bchr2031390240+0.79318180.20681824
ENST00000288078ENST00000353855FUKchr1670497624+DNMT3Bchr2031390240+0.0831223350.9168776
ENST00000288078ENST00000443239FUKchr1670497624+DNMT3Bchr2031390240+0.56690280.43309718
ENST00000288078ENST00000344505FUKchr1670497624+DNMT3Bchr2031390240+0.438867150.56113285
ENST00000428974ENST00000328111FUKchr1670497624+DNMT3Bchr2031390240+0.164808810.83519113
ENST00000428974ENST00000348286FUKchr1670497624+DNMT3Bchr2031390240+0.6185110.38148898
ENST00000428974ENST00000353855FUKchr1670497624+DNMT3Bchr2031390240+0.164808810.83519113
ENST00000428974ENST00000443239FUKchr1670497624+DNMT3Bchr2031390240+0.429414750.57058525
ENST00000428974ENST00000344505FUKchr1670497624+DNMT3Bchr2031390240+0.85523260.14476737
ENST00000378912ENST00000328111FUKchr1670497624+DNMT3Bchr2031390240+0.164808810.83519113
ENST00000378912ENST00000348286FUKchr1670497624+DNMT3Bchr2031390240+0.6185110.38148898
ENST00000378912ENST00000353855FUKchr1670497624+DNMT3Bchr2031390240+0.164808810.83519113
ENST00000378912ENST00000443239FUKchr1670497624+DNMT3Bchr2031390240+0.429414750.57058525
ENST00000378912ENST00000344505FUKchr1670497624+DNMT3Bchr2031390240+0.85523260.14476737

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Fusion Genomic Features for FUK-DNMT3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FUK-DNMT3B


check button Go to

FGviewer for the breakpoints of chr16:70497624-chr20:31390240

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNMT3B

Q9UBC3

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398). {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530, ECO:0000269|PubMed:27153398}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000201963022225_2830846.0DomainPWWP
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000201963022423_5550846.0DomainADD
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000201963022575_8530846.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000328111023225_2830854.0DomainPWWP
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000328111023423_5550854.0DomainADD
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000328111023575_8530854.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000344505021225_2830793.0DomainPWWP
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000344505021423_5550793.0DomainADD
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000344505021575_8530793.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000348286020225_2830771.0DomainPWWP
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000348286020423_5550771.0DomainADD
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000348286020575_8530771.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000353855022225_2830834.0DomainPWWP
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000353855022423_5550834.0DomainADD
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000353855022575_8530834.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000443239019225_2830729.0DomainPWWP
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000443239019423_5550729.0DomainADD
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000443239019575_8530729.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000456297018225_2830695.0DomainPWWP
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000456297018423_5550695.0DomainADD
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000456297018575_8530695.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000201963022582_5860846.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000201963022627_6290846.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000201963022832_8340846.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000328111023582_5860854.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000328111023627_6290854.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000328111023832_8340854.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000344505021582_5860793.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000344505021627_6290793.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000344505021832_8340793.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000348286020582_5860771.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000348286020627_6290771.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000348286020832_8340771.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000353855022582_5860834.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000353855022627_6290834.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000353855022832_8340834.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000443239019582_5860729.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000443239019627_6290729.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000443239019832_8340729.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000456297018582_5860695.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000456297018627_6290695.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000456297018832_8340695.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000201963022434_4640846.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000201963022475_5310846.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000328111023434_4640854.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000328111023475_5310854.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000344505021434_4640793.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000344505021475_5310793.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000348286020434_4640771.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000348286020475_5310771.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000353855022434_4640834.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000353855022475_5310834.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000443239019434_4640729.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000443239019475_5310729.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000456297018434_4640695.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000456297018475_5310695.0Zinc fingerPHD-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUKchr16:70497624chr20:31390240ENST00000288078+124834_84501085.0Nucleotide bindingATP
HgeneFUKchr16:70497624chr20:31390240ENST00000378912+124834_84501091.0Nucleotide bindingATP


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Fusion Gene Sequence for FUK-DNMT3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000288078_ENST00000328111_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=2187nt_BP=367nt
CTTCTGGATTGCAGCCCCGCTGCCCTTCAGGAAAGCGCTGCCCCGGCCACCCACGCTGGCCTATGCGGTGGCTCCGACCGTGTTTTTTGC
CGGACGGGGGCTCGGCCTTGGGGGGGCGCGGAGGTGAAACTACACTTCCCGGAGTGCACCGCGAGGGTCGCGCAGCCTCGCGTTAAAGAG
CCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGTCATCAT
CCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCGGGCAGG
CTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGGACTGCT
TGGAATACAATAGGATAGCCAAGTTAAAGAAAGTACAGACAATAACCACCAAGTCGAACTCGATCAAACAGGGGAAAAACCAACTTTTCC
CTGTTGTCATGAATGGCAAAGAAGATGTTTTGTGGTGCACTGAGCTCGAAAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCA
ACATGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACT
TTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCC
CAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAG
GGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAA
ACTTTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAA
ACCACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGG
CTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAA
GCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAG
TATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGC
CACTCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCC
ATATATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCT
CAAACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACT
AAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGC
TCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTC
AGAAATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTG
GGGCTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACG
TAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTA

>In-frame_ENST00000288078_ENST00000328111_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=118AA_start in transcript=829_stop in transcript=473
MRKSRAWGCLQESHLLGPGSATHPSGLGAWLELFTCKVVLQRGEEVSDDRHAPGPSQQLLAGTTAHVGHVCVVHRKAKDPFELSAPQNIF

--------------------------------------------------------------
>In-frame_ENST00000288078_ENST00000348286_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=1998nt_BP=367nt
CTTCTGGATTGCAGCCCCGCTGCCCTTCAGGAAAGCGCTGCCCCGGCCACCCACGCTGGCCTATGCGGTGGCTCCGACCGTGTTTTTTGC
CGGACGGGGGCTCGGCCTTGGGGGGGCGCGGAGGTGAAACTACACTTCCCGGAGTGCACCGCGAGGGTCGCGCAGCCTCGCGTTAAAGAG
CCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGTCATCAT
CCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCGGGCAGG
CTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCC
GTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTGCATGTG
AATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAGGCCCTG
CTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGGTAGCCT
GAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAA
CTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACCACAGTG
CCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGGCTACTGCTC
TGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAAGCAGAAGAG
AAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTATTTTCCA
CAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCACTCTTAG
CTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCCATATATTTT
GTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCTCAAACCCAT
TCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAACTCAGA
GGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCGGTGCTC
CCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGAAATGCT
GTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTT
ATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAACAAATA
TGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTATGTTTAATT

>In-frame_ENST00000288078_ENST00000348286_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=105AA_start in transcript=223_stop in transcript=540
MARMEQPKGVDWTVIILTCQYKDSVQVFQRVNALLVAAEHLSARAGFTPILLGQPTRDEQDLWLSCALHRRVQHGPWCPPEAAGKVLERA

--------------------------------------------------------------
>In-frame_ENST00000288078_ENST00000353855_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=2187nt_BP=367nt
CTTCTGGATTGCAGCCCCGCTGCCCTTCAGGAAAGCGCTGCCCCGGCCACCCACGCTGGCCTATGCGGTGGCTCCGACCGTGTTTTTTGC
CGGACGGGGGCTCGGCCTTGGGGGGGCGCGGAGGTGAAACTACACTTCCCGGAGTGCACCGCGAGGGTCGCGCAGCCTCGCGTTAAAGAG
CCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGTCATCAT
CCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCGGGCAGG
CTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGGACTGCT
TGGAATACAATAGGATAGCCAAGTTAAAGAAAGTACAGACAATAACCACCAAGTCGAACTCGATCAAACAGGGGAAAAACCAACTTTTCC
CTGTTGTCATGAATGGCAAAGAAGATGTTTTGTGGTGCACTGAGCTCGAAAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCA
ACATGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACT
TTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCC
CAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAG
GGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAA
ACTTTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAA
ACCACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGG
CTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAA
GCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAG
TATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGC
CACTCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCC
ATATATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCT
CAAACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACT
AAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGC
TCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTC
AGAAATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTG
GGGCTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACG
TAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTA

>In-frame_ENST00000288078_ENST00000353855_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=118AA_start in transcript=829_stop in transcript=473
MRKSRAWGCLQESHLLGPGSATHPSGLGAWLELFTCKVVLQRGEEVSDDRHAPGPSQQLLAGTTAHVGHVCVVHRKAKDPFELSAPQNIF

--------------------------------------------------------------
>In-frame_ENST00000288078_ENST00000443239_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=922nt_BP=367nt
CTTCTGGATTGCAGCCCCGCTGCCCTTCAGGAAAGCGCTGCCCCGGCCACCCACGCTGGCCTATGCGGTGGCTCCGACCGTGTTTTTTGC
CGGACGGGGGCTCGGCCTTGGGGGGGCGCGGAGGTGAAACTACACTTCCCGGAGTGCACCGCGAGGGTCGCGCAGCCTCGCGTTAAAGAG
CCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGTCATCAT
CCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCGGGCAGG
CTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCC
GTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTGCATGTG
AATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAGGCCCTG
CTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGGTAGCCT
GAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAA
CTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACCACAGTG

>In-frame_ENST00000288078_ENST00000443239_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=105AA_start in transcript=223_stop in transcript=540
MARMEQPKGVDWTVIILTCQYKDSVQVFQRVNALLVAAEHLSARAGFTPILLGQPTRDEQDLWLSCALHRRVQHGPWCPPEAAGKVLERA

--------------------------------------------------------------
>In-frame_ENST00000288078_ENST00000344505_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=2067nt_BP=367nt
CTTCTGGATTGCAGCCCCGCTGCCCTTCAGGAAAGCGCTGCCCCGGCCACCCACGCTGGCCTATGCGGTGGCTCCGACCGTGTTTTTTGC
CGGACGGGGGCTCGGCCTTGGGGGGGCGCGGAGGTGAAACTACACTTCCCGGAGTGCACCGCGAGGGTCGCGCAGCCTCGCGTTAAAGAG
CCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGTCATCAT
CCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCGGGCAGG
CTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGGACTGCT
TGGAATACAATAGGATAGCCAAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCCGTGGTGCCCGCCAGAAGCTG
CTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTGCATGTGAATAGTTCCAGCCAGGCCCC
AAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAGGCCCTGCTCTTCCTCAGCTGTGTGGG
TCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGGTAGCCTGAGGTGCCGCCTCCTTGTGC
ACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAACTTGAAGTAGGTAGCAACGT
GGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACCACAGTGCCGACAGCTCTCCAATACTC
AGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGGCTACTGCTCTGTGTTTACAGACGTGTGCA
GTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTT
TACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTATTTTCCACAATGATGATGATTTCAGCA
GGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCACTCTTAGCTAAATCCCTCCCCGTGACT
GCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCCATATATTTTGTAGACAAGTATGGCTCCTC
CATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCTCAAACCCATTCCCTCTCCAGGAGACCTAC
CCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAACTCAGAGGCAGTGACAGCAGTCAGGG
ACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCGGTGCTCCCTTTGGAGATTTTTTAATC
CTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGAAATGCTGTCATAATGGTTTTTAACAC
CTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTTATACACTTTTTAAAATCTCA
AACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAACAAATATGGGGAAAAAACTGTGCCTT

>In-frame_ENST00000288078_ENST00000344505_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=134AA_start in transcript=710_stop in transcript=306
MRKSRAWGCLQESHLLGPGSATHPSGLGAWLELFTCKVVLQRGEEVSDDRHAPGPSQQLLAGTTAHVGHVCVVHRKAKDPWLSYCIPSSP

--------------------------------------------------------------
>In-frame_ENST00000428974_ENST00000328111_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=2013nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGG
ACTGCTTGGAATACAATAGGATAGCCAAGTTAAAGAAAGTACAGACAATAACCACCAAGTCGAACTCGATCAAACAGGGGAAAAACCAAC
TTTTCCCTGTTGTCATGAATGGCAAAGAAGATGTTTTGTGGTGCACTGAGCTCGAAAGGATCTTTGGCTTTCCTGTGCACTACACAGACG
TGTCCAACATGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGG
ACTACTTTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGG
CATCCCCAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTC
TTGCAGGGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCT
CCTAAAACTTTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGAT
ACCAAAACCACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAA
AACTGGCTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCA
GGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTA
TTAGAGTATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGC
AGGGGCCACTCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAA
GCTGCCATATATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACA
CCCCCTCAAACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTT
TTTACTAAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTG
CAAAGCTCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTG
CATTTCAGAAATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGT
TTTGTGGGGCTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCC
ACGACGTAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTT

>In-frame_ENST00000428974_ENST00000328111_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=118AA_start in transcript=655_stop in transcript=299
MRKSRAWGCLQESHLLGPGSATHPSGLGAWLELFTCKVVLQRGEEVSDDRHAPGPSQQLLAGTTAHVGHVCVVHRKAKDPFELSAPQNIF

--------------------------------------------------------------
>In-frame_ENST00000428974_ENST00000348286_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=1824nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACA
TGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTG
CATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAG
GCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGG
TAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACT
TTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACC
ACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGGCTA
CTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAAGCA
GAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTAT
TTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCAC
TCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCCATA
TATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCTCAA
ACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAA
CTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCG
GTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGA
AATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGG
CTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAA
CAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTATGT

>In-frame_ENST00000428974_ENST00000348286_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=105AA_start in transcript=49_stop in transcript=366
MARMEQPKGVDWTVIILTCQYKDSVQVFQRVNALLVAAEHLSARAGFTPILLGQPTRDEQDLWLSCALHRRVQHGPWCPPEAAGKVLERA

--------------------------------------------------------------
>In-frame_ENST00000428974_ENST00000353855_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=2013nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGG
ACTGCTTGGAATACAATAGGATAGCCAAGTTAAAGAAAGTACAGACAATAACCACCAAGTCGAACTCGATCAAACAGGGGAAAAACCAAC
TTTTCCCTGTTGTCATGAATGGCAAAGAAGATGTTTTGTGGTGCACTGAGCTCGAAAGGATCTTTGGCTTTCCTGTGCACTACACAGACG
TGTCCAACATGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGG
ACTACTTTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGG
CATCCCCAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTC
TTGCAGGGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCT
CCTAAAACTTTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGAT
ACCAAAACCACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAA
AACTGGCTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCA
GGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTA
TTAGAGTATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGC
AGGGGCCACTCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAA
GCTGCCATATATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACA
CCCCCTCAAACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTT
TTTACTAAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTG
CAAAGCTCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTG
CATTTCAGAAATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGT
TTTGTGGGGCTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCC
ACGACGTAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTT

>In-frame_ENST00000428974_ENST00000353855_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=118AA_start in transcript=655_stop in transcript=299
MRKSRAWGCLQESHLLGPGSATHPSGLGAWLELFTCKVVLQRGEEVSDDRHAPGPSQQLLAGTTAHVGHVCVVHRKAKDPFELSAPQNIF

--------------------------------------------------------------
>In-frame_ENST00000428974_ENST00000443239_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=748nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACA
TGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTG
CATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAG
GCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGG
TAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACT
TTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACC

>In-frame_ENST00000428974_ENST00000443239_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=105AA_start in transcript=49_stop in transcript=366
MARMEQPKGVDWTVIILTCQYKDSVQVFQRVNALLVAAEHLSARAGFTPILLGQPTRDEQDLWLSCALHRRVQHGPWCPPEAAGKVLERA

--------------------------------------------------------------
>In-frame_ENST00000428974_ENST00000344505_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=1893nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGG
ACTGCTTGGAATACAATAGGATAGCCAAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCCGTGGTGCCCGCCAG
AAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTGCATGTGAATAGTTCCAGCCA
GGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAGGCCCTGCTCTTCCTCAGCTG
TGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGGTAGCCTGAGGTGCCGCCTCC
TTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAACTTGAAGTAGGTAG
CAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACCACAGTGCCGACAGCTCTCCA
ATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGGCTACTGCTCTGTGTTTACAGACG
TGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAAGCAGAAGAGAAAATGTTGTATAT
GTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTATTTTCCACAATGATGATGATT
TCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCACTCTTAGCTAAATCCCTCCCC
GTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCCATATATTTTGTAGACAAGTATGG
CTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCTCAAACCCATTCCCTCTCCAGGAG
ACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAACTCAGAGGCAGTGACAGCAG
TCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCGGTGCTCCCTTTGGAGATTTT
TTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGAAATGCTGTCATAATGGTTTT
TAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTTATACACTTTTTAAA
ATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAACAAATATGGGGAAAAAACTG
TGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTATGTTTAATTAAAATCAGTATTTG

>In-frame_ENST00000428974_ENST00000344505_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=134AA_start in transcript=536_stop in transcript=132
MRKSRAWGCLQESHLLGPGSATHPSGLGAWLELFTCKVVLQRGEEVSDDRHAPGPSQQLLAGTTAHVGHVCVVHRKAKDPWLSYCIPSSP

--------------------------------------------------------------
>In-frame_ENST00000378912_ENST00000328111_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=2013nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGG
ACTGCTTGGAATACAATAGGATAGCCAAGTTAAAGAAAGTACAGACAATAACCACCAAGTCGAACTCGATCAAACAGGGGAAAAACCAAC
TTTTCCCTGTTGTCATGAATGGCAAAGAAGATGTTTTGTGGTGCACTGAGCTCGAAAGGATCTTTGGCTTTCCTGTGCACTACACAGACG
TGTCCAACATGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGG
ACTACTTTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGG
CATCCCCAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTC
TTGCAGGGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCT
CCTAAAACTTTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGAT
ACCAAAACCACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAA
AACTGGCTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCA
GGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTA
TTAGAGTATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGC
AGGGGCCACTCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAA
GCTGCCATATATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACA
CCCCCTCAAACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTT
TTTACTAAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTG
CAAAGCTCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTG
CATTTCAGAAATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGT
TTTGTGGGGCTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCC
ACGACGTAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTT

>In-frame_ENST00000378912_ENST00000328111_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=118AA_start in transcript=655_stop in transcript=299
MRKSRAWGCLQESHLLGPGSATHPSGLGAWLELFTCKVVLQRGEEVSDDRHAPGPSQQLLAGTTAHVGHVCVVHRKAKDPFELSAPQNIF

--------------------------------------------------------------
>In-frame_ENST00000378912_ENST00000348286_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=1824nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACA
TGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTG
CATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAG
GCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGG
TAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACT
TTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACC
ACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGGCTA
CTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAAGCA
GAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTAT
TTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCAC
TCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCCATA
TATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCTCAA
ACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAA
CTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCG
GTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGA
AATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGG
CTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAA
CAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTATGT

>In-frame_ENST00000378912_ENST00000348286_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=105AA_start in transcript=49_stop in transcript=366
MARMEQPKGVDWTVIILTCQYKDSVQVFQRVNALLVAAEHLSARAGFTPILLGQPTRDEQDLWLSCALHRRVQHGPWCPPEAAGKVLERA

--------------------------------------------------------------
>In-frame_ENST00000378912_ENST00000353855_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=2013nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGG
ACTGCTTGGAATACAATAGGATAGCCAAGTTAAAGAAAGTACAGACAATAACCACCAAGTCGAACTCGATCAAACAGGGGAAAAACCAAC
TTTTCCCTGTTGTCATGAATGGCAAAGAAGATGTTTTGTGGTGCACTGAGCTCGAAAGGATCTTTGGCTTTCCTGTGCACTACACAGACG
TGTCCAACATGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGG
ACTACTTTGCATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGG
CATCCCCAGGCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTC
TTGCAGGGGTAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCT
CCTAAAACTTTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGAT
ACCAAAACCACAGTGCCGACAGCTCTCCAATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAA
AACTGGCTACTGCTCTGTGTTTACAGACGTGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCA
GGGCAAGCAGAAGAGAAAATGTTGTATATGTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTA
TTAGAGTATTTTCCACAATGATGATGATTTCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGC
AGGGGCCACTCTTAGCTAAATCCCTCCCCGTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAA
GCTGCCATATATTTTGTAGACAAGTATGGCTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACA
CCCCCTCAAACCCATTCCCTCTCCAGGAGACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTT
TTTACTAAACTCAGAGGCAGTGACAGCAGTCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTG
CAAAGCTCGGTGCTCCCTTTGGAGATTTTTTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTG
CATTTCAGAAATGCTGTCATAATGGTTTTTAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGT
TTTGTGGGGCTTTTTATACACTTTTTAAAATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCC
ACGACGTAACAAATATGGGGAAAAAACTGTGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTT

>In-frame_ENST00000378912_ENST00000353855_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=118AA_start in transcript=655_stop in transcript=299
MRKSRAWGCLQESHLLGPGSATHPSGLGAWLELFTCKVVLQRGEEVSDDRHAPGPSQQLLAGTTAHVGHVCVVHRKAKDPFELSAPQNIF

--------------------------------------------------------------
>In-frame_ENST00000378912_ENST00000443239_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=748nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACA
TGGGCCGTGGTGCCCGCCAGAAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTG
CATGTGAATAGTTCCAGCCAGGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAG
GCCCTGCTCTTCCTCAGCTGTGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGG
TAGCCTGAGGTGCCGCCTCCTTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACT
TTAAAACTTGAAGTAGGTAGCAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACC

>In-frame_ENST00000378912_ENST00000443239_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=105AA_start in transcript=49_stop in transcript=366
MARMEQPKGVDWTVIILTCQYKDSVQVFQRVNALLVAAEHLSARAGFTPILLGQPTRDEQDLWLSCALHRRVQHGPWCPPEAAGKVLERA

--------------------------------------------------------------
>In-frame_ENST00000378912_ENST00000344505_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(transcript)=1893nt_BP=193nt
AAAGAGCCCGCTCCGCCGAGCGCCGGGCGACGGCAGGAAGCCCCTCCGCTTGGCCAGAATGGAGCAGCCGAAGGGAGTTGATTGGACAGT
CATCATCCTGACCTGCCAGTACAAGGACAGTGTCCAGGTCTTTCAGAGAGTCAACGCCCTGCTGGTGGCTGCTGAACACCTGAGTGCCCG
GGCAGGCTTCACTCCGATACTTCTGGGGCAACCTACCCGGGATGAACAGGCCCGTGATAGCATCAAAGAATGATAAACTCGAGCTGCAGG
ACTGCTTGGAATACAATAGGATAGCCAAGGATCTTTGGCTTTCCTGTGCACTACACAGACGTGTCCAACATGGGCCGTGGTGCCCGCCAG
AAGCTGCTGGGAAGGTCCTGGAGCGTGCCTGTCATCCGACACCTCTTCGCCCCTCTGAAGGACTACTTTGCATGTGAATAGTTCCAGCCA
GGCCCCAAGCCCACTGGGGTGTGTGGCAGAGCCAGGACCCAGGAGGTGTGATTCCTGAAGGCATCCCCAGGCCCTGCTCTTCCTCAGCTG
TGTGGGTCATACCGTGTACCTCAGTTCCCTCTTGCTCAGTGGGGGCAGAGCCACCTGACTCTTGCAGGGGTAGCCTGAGGTGCCGCCTCC
TTGTGCACAAATCAGACCTGGCTGCTTGGAGCAGCCTAACACGGTGCTCATTTTTTCTTCTCCTAAAACTTTAAAACTTGAAGTAGGTAG
CAACGTGGCTTTTTTTTTTTCCCTTCCTGGGTCTACCACTCAGAGAAACAATGGCTAAGATACCAAAACCACAGTGCCGACAGCTCTCCA
ATACTCAGGTTAATGCTGAAAAATCATCCAAGACAGTTATTGCAAGAGTTTAATTTTTGAAAACTGGCTACTGCTCTGTGTTTACAGACG
TGTGCAGTTGTAGGCATGTAGCTACAGGACATTTTTAAGGGCCCAGGATCGTTTTTTCCCAGGGCAAGCAGAAGAGAAAATGTTGTATAT
GTCTTTTACCCGGCACATTCCCCTTGCCTAAATACAAGGGCTGGAGTCTGCACGGGACCTATTAGAGTATTTTCCACAATGATGATGATT
TCAGCAGGGATGACGTCATCATCACATTCAGGGCTATTTTTTCCCCCACAAACCCAAGGGCAGGGGCCACTCTTAGCTAAATCCCTCCCC
GTGACTGCAATAGAACCCTCTGGGGAGCTCAGGAAGGGGTGTGCTGAGTTCTATAATATAAGCTGCCATATATTTTGTAGACAAGTATGG
CTCCTCCATATCTCCCTCTTCCCTAGGAGAGGAGTGTGAAGCAAGGAGCTTAGATAAGACACCCCCTCAAACCCATTCCCTCTCCAGGAG
ACCTACCCTCCACAGGCACAGGTCCCCAGATGAGAAGTCTGCTACCCTCATTTCTCATCTTTTTACTAAACTCAGAGGCAGTGACAGCAG
TCAGGGACAGACATACATTTCTCATACCTTCCCCACATCTGAGAGATGACAGGGAAAACTGCAAAGCTCGGTGCTCCCTTTGGAGATTTT
TTAATCCTTTTTTATTCCATAAGAAGTCGTTTTTAGGGAGAACGGGAATTCAGACAAGCTGCATTTCAGAAATGCTGTCATAATGGTTTT
TAACACCTTTTACTCTTCTTACTGGTGCTATTTTGTAGAATAAGGAACAACGTTGACAAGTTTTGTGGGGCTTTTTATACACTTTTTAAA
ATCTCAAACTTCTATTTTTATGTTTAACGTTTTCATTAAAATTTTTTTTGTAACTGGAGCCACGACGTAACAAATATGGGGAAAAAACTG
TGCCTTGTTTCAACAGTTTTTGCTAATTTTTAGGCTGAAAGATGACGGATGCCTAGAGTTTACCTTATGTTTAATTAAAATCAGTATTTG

>In-frame_ENST00000378912_ENST00000344505_DB451208_FUK_chr16_70497624_+_DNMT3B_chr20_31390240_length(amino acids)=134AA_start in transcript=536_stop in transcript=132
MRKSRAWGCLQESHLLGPGSATHPSGLGAWLELFTCKVVLQRGEEVSDDRHAPGPSQQLLAGTTAHVGHVCVVHRKAKDPWLSYCIPSSP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FUK-DNMT3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDNMT3Bchr16:70497624chr20:31390240ENST000002019630221_2980846.0DNMT1 and DNMT3A
TgeneDNMT3Bchr16:70497624chr20:31390240ENST000003281110231_2980854.0DNMT1 and DNMT3A
TgeneDNMT3Bchr16:70497624chr20:31390240ENST000003445050211_2980793.0DNMT1 and DNMT3A
TgeneDNMT3Bchr16:70497624chr20:31390240ENST000003482860201_2980771.0DNMT1 and DNMT3A
TgeneDNMT3Bchr16:70497624chr20:31390240ENST000003538550221_2980834.0DNMT1 and DNMT3A
TgeneDNMT3Bchr16:70497624chr20:31390240ENST000004432390191_2980729.0DNMT1 and DNMT3A
TgeneDNMT3Bchr16:70497624chr20:31390240ENST000004562970181_2980695.0DNMT1 and DNMT3A
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000201963022435_5270846.0the PRC2/EED-EZH2 complex
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000328111023435_5270854.0the PRC2/EED-EZH2 complex
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000344505021435_5270793.0the PRC2/EED-EZH2 complex
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000348286020435_5270771.0the PRC2/EED-EZH2 complex
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000353855022435_5270834.0the PRC2/EED-EZH2 complex
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000443239019435_5270729.0the PRC2/EED-EZH2 complex
TgeneDNMT3Bchr16:70497624chr20:31390240ENST00000456297018435_5270695.0the PRC2/EED-EZH2 complex


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FUK-DNMT3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneDNMT3BQ9UBC3DB01262DecitabineInhibitorSmall moleculeApproved|Investigational

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Related Diseases for FUK-DNMT3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDNMT3BC4551557IMMUNODEFICIENCY-CENTROMERIC INSTABILITY-FACIAL ANOMALIES SYNDROME 111CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneDNMT3BC0006142Malignant neoplasm of breast2CTD_human
TgeneDNMT3BC0678222Breast Carcinoma2CTD_human
TgeneDNMT3BC1257931Mammary Neoplasms, Human2CTD_human
TgeneDNMT3BC1458155Mammary Neoplasms2CTD_human
TgeneDNMT3BC4704874Mammary Carcinoma, Human2CTD_human
TgeneDNMT3BC0003257Antibody Deficiency Syndrome1CTD_human
TgeneDNMT3BC0007097Carcinoma1CTD_human
TgeneDNMT3BC0021051Immunologic Deficiency Syndromes1CTD_human
TgeneDNMT3BC0024623Malignant neoplasm of stomach1CTD_human
TgeneDNMT3BC0033578Prostatic Neoplasms1CTD_human
TgeneDNMT3BC0036341Schizophrenia1PSYGENET
TgeneDNMT3BC0038356Stomach Neoplasms1CTD_human
TgeneDNMT3BC0205696Anaplastic carcinoma1CTD_human
TgeneDNMT3BC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneDNMT3BC0205698Undifferentiated carcinoma1CTD_human
TgeneDNMT3BC0205699Carcinomatosis1CTD_human
TgeneDNMT3BC0376358Malignant neoplasm of prostate1CTD_human
TgeneDNMT3BC0376634Craniofacial Abnormalities1CTD_human
TgeneDNMT3BC0525045Mood Disorders1PSYGENET
TgeneDNMT3BC0796113Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor1GENOMICS_ENGLAND
TgeneDNMT3BC1510586Autism Spectrum Disorders1CTD_human
TgeneDNMT3BC1656427Early onset schizophrenia1PSYGENET
TgeneDNMT3BC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneDNMT3BC1834671FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1B1UNIPROT
TgeneDNMT3BC2931456Prostate cancer, familial1CTD_human
TgeneDNMT3BC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human