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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FUS-ALDH9A1 (FusionGDB2 ID:31683)

Fusion Gene Summary for FUS-ALDH9A1

check button Fusion gene summary
Fusion gene informationFusion gene name: FUS-ALDH9A1
Fusion gene ID: 31683
HgeneTgene
Gene symbol

FUS

ALDH9A1

Gene ID

2521

223

Gene nameFUS RNA binding proteinaldehyde dehydrogenase 9 family member A1
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSALDH4|ALDH7|ALDH9|E3|TMABA-DH|TMABADH|TMABALDH
Cytomap

16p11.2

1q24.1

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma protein4-trimethylaminobutyraldehyde dehydrogenaseR-aminobutyraldehyde dehydrogenasealdehyde dehydrogenase (NAD+)aldehyde dehydrogenase E3 isozymealdehyde dehydrogenase family 9 member A1gamma-aminobutyraldehyde dehydrogenase
Modification date2020032920200313
UniProtAcc

P35637

P49189

Ensembl transtripts involved in fusion geneENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000354775, ENST00000538148, 
ENST00000461664, 
Fusion gene scores* DoF score37 X 37 X 16=219044 X 3 X 3=36
# samples 444
** MAII scorelog2(44/21904*10)=-5.63754701773324
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FUS [Title/Abstract] AND ALDH9A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFUS(31196500)-ALDH9A1(165634367), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

HgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

HgeneFUS

GO:0008380

RNA splicing

26124092

HgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

HgeneFUS

GO:0048255

mRNA stabilization

27378374

HgeneFUS

GO:0051260

protein homooligomerization

25453086

HgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410

TgeneALDH9A1

GO:0006081

cellular aldehyde metabolic process

8645224|30914451

TgeneALDH9A1

GO:0042136

neurotransmitter biosynthetic process

2925663

TgeneALDH9A1

GO:0051289

protein homotetramerization

30914451

TgeneALDH9A1

GO:0055114

oxidation-reduction process

2925663


check buttonFusion gene breakpoints across FUS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ALDH9A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A12FFUSchr16

31196500

+ALDH9A1chr1

165634367

-


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Fusion Gene ORF analysis for FUS-ALDH9A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000254108ENST00000354775FUSchr16

31196500

+ALDH9A1chr1

165634367

-
In-frameENST00000254108ENST00000538148FUSchr16

31196500

+ALDH9A1chr1

165634367

-
5CDS-intronENST00000254108ENST00000461664FUSchr16

31196500

+ALDH9A1chr1

165634367

-
In-frameENST00000380244ENST00000354775FUSchr16

31196500

+ALDH9A1chr1

165634367

-
In-frameENST00000380244ENST00000538148FUSchr16

31196500

+ALDH9A1chr1

165634367

-
5CDS-intronENST00000380244ENST00000461664FUSchr16

31196500

+ALDH9A1chr1

165634367

-
In-frameENST00000568685ENST00000354775FUSchr16

31196500

+ALDH9A1chr1

165634367

-
In-frameENST00000568685ENST00000538148FUSchr16

31196500

+ALDH9A1chr1

165634367

-
5CDS-intronENST00000568685ENST00000461664FUSchr16

31196500

+ALDH9A1chr1

165634367

-
intron-3CDSENST00000474990ENST00000354775FUSchr16

31196500

+ALDH9A1chr1

165634367

-
intron-3CDSENST00000474990ENST00000538148FUSchr16

31196500

+ALDH9A1chr1

165634367

-
intron-intronENST00000474990ENST00000461664FUSchr16

31196500

+ALDH9A1chr1

165634367

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254108FUSchr1631196500+ENST00000354775ALDH9A1chr1165634367-1911869271076349
ENST00000254108FUSchr1631196500+ENST00000538148ALDH9A1chr1165634367-1316869271076349
ENST00000380244FUSchr1631196500+ENST00000354775ALDH9A1chr1165634367-1879837521044330
ENST00000380244FUSchr1631196500+ENST00000538148ALDH9A1chr1165634367-1284837521044330
ENST00000568685FUSchr1631196500+ENST00000354775ALDH9A1chr1165634367-1870828401035331
ENST00000568685FUSchr1631196500+ENST00000538148ALDH9A1chr1165634367-1275828401035331

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254108ENST00000354775FUSchr1631196500+ALDH9A1chr1165634367-0.0028573740.9971426
ENST00000254108ENST00000538148FUSchr1631196500+ALDH9A1chr1165634367-0.0055531020.9944469
ENST00000380244ENST00000354775FUSchr1631196500+ALDH9A1chr1165634367-0.0010498520.9989502
ENST00000380244ENST00000538148FUSchr1631196500+ALDH9A1chr1165634367-0.0026911240.99730885
ENST00000568685ENST00000354775FUSchr1631196500+ALDH9A1chr1165634367-0.0027976980.9972023
ENST00000568685ENST00000538148FUSchr1631196500+ALDH9A1chr1165634367-0.0057802210.9942198

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Fusion Genomic Features for FUS-ALDH9A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FUS-ALDH9A1


check button Go to

FGviewer for the breakpoints of chr16:31196500-chr1:165634367

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

ALDH9A1

P49189

FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.FUNCTION: Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. {ECO:0000269|PubMed:10702312, ECO:0000269|PubMed:30914451, ECO:0000269|PubMed:8645224}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31196500chr1:165634367ENST00000254108+6151_165254.66666666666666527.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
HgeneFUSchr16:31196500chr1:165634367ENST00000380244+6151_165253.66666666666666526.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31196500chr1:165634367ENST00000254108+615166_267254.66666666666666527.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31196500chr1:165634367ENST00000254108+615371_526254.66666666666666527.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31196500chr1:165634367ENST00000380244+615166_267253.66666666666666526.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31196500chr1:165634367ENST00000380244+615371_526253.66666666666666526.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31196500chr1:165634367ENST00000254108+615285_371254.66666666666666527.0DomainRRM
HgeneFUSchr16:31196500chr1:165634367ENST00000380244+615285_371253.66666666666666526.0DomainRRM
HgeneFUSchr16:31196500chr1:165634367ENST00000254108+615422_453254.66666666666666527.0Zinc fingerRanBP2-type
HgeneFUSchr16:31196500chr1:165634367ENST00000380244+615422_453253.66666666666666526.0Zinc fingerRanBP2-type
TgeneALDH9A1chr16:31196500chr1:165634367ENST00000354775811232_236449.6666666666667519.0Nucleotide bindingNAD


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Fusion Gene Sequence for FUS-ALDH9A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000254108_ENST00000354775_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(transcript)=1911nt_BP=869nt
ACTTAAGCTTCGACGCAGGAGGCGGGGCTGCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTG
CGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTAT
TCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTAT
TCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAG
AGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGC
AGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAG
CAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGT
AACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGC
GGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGC
AGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGGAGGCAGAGGTGGCATGGGGGACATCCAACGGGCTCATAGAGTGGTAGCT
GAGCTTCAGGCTGGGACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAGAAGTCAGGATTTGGC
AGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGAAAA
CCTGCAGTGAAACCTATTGACATGGCCACGCTGTGGAATGATGTGAATTGGCCCTGTTTACAGAGGCAGTACAACTGAATGTTATTTTAC
ATCCAGAATTTTGGCGTTCAGTATAAGAGAATGGTTCATGTTACTCTTTCTCTCTCCATCAGCTTCCTCACTGAAAATGTGCATTAAGTG
CCTTGTAGATACTAATCAAGAAAGCTGTGATTCTCCTCAAAGCGTATTTTTGTGAAATCTTTTAAGAGCCAGTAACATACTTCTAGAGAA
CAGGAAAAGAGACTAGGATAATACATCTTCCACACATTTGGCCCACTGATAATGTTAATTCTCTGGCGTATTTCAAAGAACTTGTTCCTG
GCTGATCCAAGTGCAGTGGTATTTACAACTAATTGATCACAACCAGTTTGTAGATTTCTTTGTTCCTTCTCCATTCCCACTGCTTCACTT
GCCTAGTCTTGAAGAAAAAAAACAAAAAACAAAAAAAAACCTTGTTCCTTTATAGGTTCCTGGTAGAATCAGTAGAGATGATTTCAGCTC
ATTGACATTTTTTTAAGCTATATCCCCTTGTCATTCCATTGAGAAAGCTGACAACTGGGATAGGGAGGGGATTAGATAATAGATGGGGTC
AAATTCTGTGTGAATGTGAACTTGCCTAGTAAGCACTTTGTCTCTGTTCACTACTGCGATAGAGGAAATCTATCTCCCTATCTTGGGTCC
TTGAACTACAGCCTGCTGTCTTACACCAGTGGAGCTACCCTTTAAATGTACAAATTATTTGTATGCTAATGTAATATGGTGAAATTAAAA

>In-frame_ENST00000254108_ENST00000354775_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(amino acids)=349AA_start in transcript=27_stop in transcript=1076
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR

--------------------------------------------------------------
>In-frame_ENST00000254108_ENST00000538148_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(transcript)=1316nt_BP=869nt
ACTTAAGCTTCGACGCAGGAGGCGGGGCTGCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTG
CGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTAT
TCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTAT
TCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAG
AGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGC
AGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAG
CAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGT
AACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGC
GGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGC
AGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGGAGGCAGAGGTGGCATGGGGGACATCCAACGGGCTCATAGAGTGGTAGCT
GAGCTTCAGGCTGGGACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAGAAGTCAGGATTTGGC
AGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCTGAAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGAAAA
CCTGCAGTGAAACCTATTGACATGGCCACGCTGTGGAATGATGTGAATTGGCCCTGTTTACAGAGGCAGTACAACTGAATGTTATTTTAC
ATCCAGAATTTTGGCGTTCAGTATAAGAGAATGGTTCATGTTACTCTTTCTCTCTCCATCAGCTTCCTCACTGAAAATGTGCATTAAGTG

>In-frame_ENST00000254108_ENST00000538148_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(amino acids)=349AA_start in transcript=27_stop in transcript=1076
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR

--------------------------------------------------------------
>In-frame_ENST00000380244_ENST00000354775_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(transcript)=1879nt_BP=837nt
GCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGA
TTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACA
GCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACAGCTA
TGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTC
CTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCA
GAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGG
ACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAG
TGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCG
CGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGG
TGGCCGTGGAGGCAGAGGTGGCATGGGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGGACGTGCTTCATTAACAA
CTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAGAAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTA
TTCACAGCTGAAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGAAAACCTGCAGTGAAACCTATTGACATGGCCACGCT
GTGGAATGATGTGAATTGGCCCTGTTTACAGAGGCAGTACAACTGAATGTTATTTTACATCCAGAATTTTGGCGTTCAGTATAAGAGAAT
GGTTCATGTTACTCTTTCTCTCTCCATCAGCTTCCTCACTGAAAATGTGCATTAAGTGCCTTGTAGATACTAATCAAGAAAGCTGTGATT
CTCCTCAAAGCGTATTTTTGTGAAATCTTTTAAGAGCCAGTAACATACTTCTAGAGAACAGGAAAAGAGACTAGGATAATACATCTTCCA
CACATTTGGCCCACTGATAATGTTAATTCTCTGGCGTATTTCAAAGAACTTGTTCCTGGCTGATCCAAGTGCAGTGGTATTTACAACTAA
TTGATCACAACCAGTTTGTAGATTTCTTTGTTCCTTCTCCATTCCCACTGCTTCACTTGCCTAGTCTTGAAGAAAAAAAACAAAAAACAA
AAAAAAACCTTGTTCCTTTATAGGTTCCTGGTAGAATCAGTAGAGATGATTTCAGCTCATTGACATTTTTTTAAGCTATATCCCCTTGTC
ATTCCATTGAGAAAGCTGACAACTGGGATAGGGAGGGGATTAGATAATAGATGGGGTCAAATTCTGTGTGAATGTGAACTTGCCTAGTAA
GCACTTTGTCTCTGTTCACTACTGCGATAGAGGAAATCTATCTCCCTATCTTGGGTCCTTGAACTACAGCCTGCTGTCTTACACCAGTGG

>In-frame_ENST00000380244_ENST00000354775_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(amino acids)=330AA_start in transcript=52_stop in transcript=1044
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGDIQRAHRV

--------------------------------------------------------------
>In-frame_ENST00000380244_ENST00000538148_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(transcript)=1284nt_BP=837nt
GCTCAGTCCTCCAGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGA
TTATACCCAACAAGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACA
GCAGAGTTACAGTGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACAGCTA
TGGAACTCAGTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTC
CTACCCTGGCTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCA
GAGTGGGAGCTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGG
ACAGCAGAACCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAG
TGGTGGTGGCAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCG
CGGCAGGGGTGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGG
TGGCCGTGGAGGCAGAGGTGGCATGGGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGGACGTGCTTCATTAACAA
CTATAACGTCAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAGAAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTA
TTCACAGCTGAAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGAAAACCTGCAGTGAAACCTATTGACATGGCCACGCT
GTGGAATGATGTGAATTGGCCCTGTTTACAGAGGCAGTACAACTGAATGTTATTTTACATCCAGAATTTTGGCGTTCAGTATAAGAGAAT
GGTTCATGTTACTCTTTCTCTCTCCATCAGCTTCCTCACTGAAAATGTGCATTAAGTGCCTTGTAGATACTAATCAAGAAAGCTGTGATT

>In-frame_ENST00000380244_ENST00000538148_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(amino acids)=330AA_start in transcript=52_stop in transcript=1044
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGDIQRAHRV

--------------------------------------------------------------
>In-frame_ENST00000568685_ENST00000354775_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(transcript)=1870nt_BP=828nt
AGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACA
AGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAG
TGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCA
GTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGG
CTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAG
CTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAA
CCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGG
CAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGG
TGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGG
AGGCAGAGGTGGCATGGGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGGACGTGCTTCATTAACAACTATAACGT
CAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAGAAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCT
GAAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGAAAACCTGCAGTGAAACCTATTGACATGGCCACGCTGTGGAATGA
TGTGAATTGGCCCTGTTTACAGAGGCAGTACAACTGAATGTTATTTTACATCCAGAATTTTGGCGTTCAGTATAAGAGAATGGTTCATGT
TACTCTTTCTCTCTCCATCAGCTTCCTCACTGAAAATGTGCATTAAGTGCCTTGTAGATACTAATCAAGAAAGCTGTGATTCTCCTCAAA
GCGTATTTTTGTGAAATCTTTTAAGAGCCAGTAACATACTTCTAGAGAACAGGAAAAGAGACTAGGATAATACATCTTCCACACATTTGG
CCCACTGATAATGTTAATTCTCTGGCGTATTTCAAAGAACTTGTTCCTGGCTGATCCAAGTGCAGTGGTATTTACAACTAATTGATCACA
ACCAGTTTGTAGATTTCTTTGTTCCTTCTCCATTCCCACTGCTTCACTTGCCTAGTCTTGAAGAAAAAAAACAAAAAACAAAAAAAAACC
TTGTTCCTTTATAGGTTCCTGGTAGAATCAGTAGAGATGATTTCAGCTCATTGACATTTTTTTAAGCTATATCCCCTTGTCATTCCATTG
AGAAAGCTGACAACTGGGATAGGGAGGGGATTAGATAATAGATGGGGTCAAATTCTGTGTGAATGTGAACTTGCCTAGTAAGCACTTTGT
CTCTGTTCACTACTGCGATAGAGGAAATCTATCTCCCTATCTTGGGTCCTTGAACTACAGCCTGCTGTCTTACACCAGTGGAGCTACCCT

>In-frame_ENST00000568685_ENST00000354775_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(amino acids)=331AA_start in transcript=40_stop in transcript=1035
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGDIQRAHR

--------------------------------------------------------------
>In-frame_ENST00000568685_ENST00000538148_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(transcript)=1275nt_BP=828nt
AGGCGTCGGTACTCAGCGGTGTTGGAACTTCGTTGCTTGCTTGCCTGTGCGCGCGTGCGCGGACATGGCCTCAAACGATTATACCCAACA
AGCAACCCAAAGCTATGGGGCCTACCCCACCCAGCCCGGGCAGGGCTATTCCCAGCAGAGCAGTCAGCCCTACGGACAGCAGAGTTACAG
TGGTTATAGCCAGTCCACGGACACTTCAGGCTATGGCCAGAGCAGCTATTCTTCTTATGGCCAGAGCCAGAACACAGGCTATGGAACTCA
GTCAACTCCCCAGGGATATGGCTCGACTGGCGGCTATGGCAGTAGCCAGAGCTCCCAATCGTCTTACGGGCAGCAGTCCTCCTACCCTGG
CTATGGCCAGCAGCCAGCTCCCAGCAGCACCTCGGGAAGTTACGGTAGCAGTTCTCAGAGCAGCAGCTATGGGCAGCCCCAGAGTGGGAG
CTACAGCCAGCAGCCTAGCTATGGTGGACAGCAGCAAAGCTATGGACAGCAGCAAAGCTATAATCCCCCTCAGGGCTATGGACAGCAGAA
CCAGTACAACAGCAGCAGTGGTGGTGGAGGTGGAGGTGGAGGTGGAGGTAACTATGGCCAAGATCAATCCTCCATGAGTAGTGGTGGTGG
CAGTGGTGGCGGTTATGGCAATCAAGACCAGAGTGGTGGAGGTGGCAGCGGTGGCTATGGACAGCAGGACCGTGGAGGCCGCGGCAGGGG
TGGCAGTGGTGGCGGCGGCGGCGGCGGCGGTGGTGGTTACAACCGCAGCAGTGGTGGCTATGAACCCAGAGGTCGTGGAGGTGGCCGTGG
AGGCAGAGGTGGCATGGGGGACATCCAACGGGCTCATAGAGTGGTAGCTGAGCTTCAGGCTGGGACGTGCTTCATTAACAACTATAACGT
CAGCCCAGTGGAGTTGCCCTTTGGTGGATATAAGAAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATATTATTCACAGCT
GAAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGAAAACCTGCAGTGAAACCTATTGACATGGCCACGCTGTGGAATGA
TGTGAATTGGCCCTGTTTACAGAGGCAGTACAACTGAATGTTATTTTACATCCAGAATTTTGGCGTTCAGTATAAGAGAATGGTTCATGT
TACTCTTTCTCTCTCCATCAGCTTCCTCACTGAAAATGTGCATTAAGTGCCTTGTAGATACTAATCAAGAAAGCTGTGATTCTCCTCAAA

>In-frame_ENST00000568685_ENST00000538148_TCGA-AO-A12F_FUS_chr16_31196500_+_ALDH9A1_chr1_165634367_length(amino acids)=331AA_start in transcript=40_stop in transcript=1035
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGDIQRAHR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FUS-ALDH9A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FUS-ALDH9A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneALDH9A1P49189DB00157NADHSmall moleculeApproved|Nutraceutical
TgeneALDH9A1P49189DB00157NADHSmall moleculeApproved|Nutraceutical
TgeneALDH9A1P49189DB00157NADHSmall moleculeApproved|Nutraceutical
TgeneALDH9A1P49189DB00157NADHSmall moleculeApproved|Nutraceutical

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Related Diseases for FUS-ALDH9A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
HgeneFUSC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
HgeneFUSC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneFUSC0497327Dementia1GENOMICS_ENGLAND
HgeneFUSC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
HgeneFUSC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET
TgeneALDH9A1C0019193Hepatitis, Toxic1CTD_human
TgeneALDH9A1C0860207Drug-Induced Liver Disease1CTD_human
TgeneALDH9A1C1262760Hepatitis, Drug-Induced1CTD_human
TgeneALDH9A1C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneALDH9A1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneALDH9A1C4279912Chemically-Induced Liver Toxicity1CTD_human