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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FUS-CREB3L2 (FusionGDB2 ID:31688)

Fusion Gene Summary for FUS-CREB3L2

check button Fusion gene summary
Fusion gene informationFusion gene name: FUS-CREB3L2
Fusion gene ID: 31688
HgeneTgene
Gene symbol

FUS

CREB3L2

Gene ID

2521

64764

Gene nameFUS RNA binding proteincAMP responsive element binding protein 3 like 2
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSBBF2H7
Cytomap

16p11.2

7q33

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma proteincyclic AMP-responsive element-binding protein 3-like protein 2B-ZIB transcription factorBBF2 human homolog on chromosome 7FUS/BBF2H7 proteinTCAG_1951439basic transcription factor 2cAMP-responsive element-binding protein 3-like protein 2
Modification date2020032920200313
UniProtAcc

P35637

Q70SY1

Ensembl transtripts involved in fusion geneENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000330387, ENST00000456390, 
ENST00000452463, ENST00000458726, 
ENST00000468127, 
Fusion gene scores* DoF score37 X 37 X 16=219045 X 10 X 5=250
# samples 449
** MAII scorelog2(44/21904*10)=-5.63754701773324
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/250*10)=-1.47393118833241
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FUS [Title/Abstract] AND CREB3L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREB3L2(137686349)-FUS(31199645), # samples:2
FUS(31199514)-CREB3L2(137565145), # samples:1
FUS(31199478)-CREB3L2(137593090), # samples:1
FUS(31196384)-CREB3L2(137593099), # samples:1
FUS(31196358)-CREB3L2(137664456), # samples:1
Anticipated loss of major functional domain due to fusion event.CREB3L2-FUS seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CREB3L2-FUS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FUS-CREB3L2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

HgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

HgeneFUS

GO:0008380

RNA splicing

26124092

HgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

HgeneFUS

GO:0048255

mRNA stabilization

27378374

HgeneFUS

GO:0051260

protein homooligomerization

25453086

HgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410

TgeneCREB3L2

GO:0045893

positive regulation of transcription, DNA-templated

17178827


check buttonFusion gene breakpoints across FUS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CREB3L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4fibromyxoid sarcomaAJ549093FUSchr16

31199514

CREB3L2chr7

137565145

ChiTaRS5.0N/AAJ549093FUSchr16

31199478

-CREB3L2chr7

137593090

-
ChiTaRS5.0N/AAJ549094FUSchr16

31196384

+CREB3L2chr7

137593099

-
ChiTaRS5.0N/AAJ549097FUSchr16

31196358

+CREB3L2chr7

137664456

-


Top

Fusion Gene ORF analysis for FUS-CREB3L2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000254108ENST00000330387FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000254108ENST00000456390FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000254108ENST00000452463FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000254108ENST00000458726FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000254108ENST00000468127FUSchr16

31199514

CREB3L2chr7

137565145

intron-3UTRENST00000380244ENST00000330387FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000380244ENST00000456390FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000380244ENST00000452463FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000380244ENST00000458726FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000380244ENST00000468127FUSchr16

31199514

CREB3L2chr7

137565145

intron-3UTRENST00000568685ENST00000330387FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000568685ENST00000456390FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000568685ENST00000452463FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000568685ENST00000458726FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000568685ENST00000468127FUSchr16

31199514

CREB3L2chr7

137565145

intron-3UTRENST00000474990ENST00000330387FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000474990ENST00000456390FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000474990ENST00000452463FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000474990ENST00000458726FUSchr16

31199514

CREB3L2chr7

137565145

intron-intronENST00000474990ENST00000468127FUSchr16

31199514

CREB3L2chr7

137565145

intron-3CDSENST00000254108ENST00000330387FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000254108ENST00000456390FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000254108ENST00000452463FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000254108ENST00000458726FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000254108ENST00000468127FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000380244ENST00000330387FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000380244ENST00000456390FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000380244ENST00000452463FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000380244ENST00000458726FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000380244ENST00000468127FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000568685ENST00000330387FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000568685ENST00000456390FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000568685ENST00000452463FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000568685ENST00000458726FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000568685ENST00000468127FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000474990ENST00000330387FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-3CDSENST00000474990ENST00000456390FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000474990ENST00000452463FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000474990ENST00000458726FUSchr16

31199478

-CREB3L2chr7

137593090

-
intron-intronENST00000474990ENST00000468127FUSchr16

31199478

-CREB3L2chr7

137593090

-
Frame-shiftENST00000254108ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shiftENST00000254108ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000254108ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000254108ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000254108ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shiftENST00000380244ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shiftENST00000380244ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000380244ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000380244ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000380244ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shiftENST00000568685ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137593099

-
Frame-shiftENST00000568685ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000568685ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000568685ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000568685ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-3CDSENST00000474990ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-3CDSENST00000474990ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-intronENST00000474990ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-intronENST00000474990ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137593099

-
intron-intronENST00000474990ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137593099

-
5CDS-intronENST00000254108ENST00000330387FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000254108ENST00000456390FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000254108ENST00000452463FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000254108ENST00000458726FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000254108ENST00000468127FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000380244ENST00000330387FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000380244ENST00000456390FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000380244ENST00000452463FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000380244ENST00000458726FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000380244ENST00000468127FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000568685ENST00000330387FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000568685ENST00000456390FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000568685ENST00000452463FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000568685ENST00000458726FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-intronENST00000568685ENST00000468127FUSchr16

31196358

+CREB3L2chr7

137664456

-
intron-intronENST00000474990ENST00000330387FUSchr16

31196358

+CREB3L2chr7

137664456

-
intron-intronENST00000474990ENST00000456390FUSchr16

31196358

+CREB3L2chr7

137664456

-
intron-intronENST00000474990ENST00000452463FUSchr16

31196358

+CREB3L2chr7

137664456

-
intron-intronENST00000474990ENST00000458726FUSchr16

31196358

+CREB3L2chr7

137664456

-
intron-intronENST00000474990ENST00000468127FUSchr16

31196358

+CREB3L2chr7

137664456

-
5CDS-3UTRENST00000254108ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-3UTRENST00000380244ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-3UTRENST00000568685ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000254108ENST00000452463FUSchr16

31195705

+CREB3L2chr7

137590594

-
5CDS-intronENST00000254108ENST00000452463FUSchr16

31195705

+CREB3L2chr7

137593182

-
5CDS-intronENST00000254108ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000254108ENST00000452463FUSchr16

31196500

+CREB3L2chr

137593182

-
5CDS-intronENST00000254108ENST00000452463FUSchr16

31196500

+CREB3L2chr7

137593182

-
5CDS-intronENST00000254108ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000254108ENST00000458726FUSchr16

31195705

+CREB3L2chr7

137590594

-
5CDS-intronENST00000254108ENST00000458726FUSchr16

31195705

+CREB3L2chr7

137593182

-
5CDS-intronENST00000254108ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000254108ENST00000458726FUSchr16

31196500

+CREB3L2chr

137593182

-
5CDS-intronENST00000254108ENST00000458726FUSchr16

31196500

+CREB3L2chr7

137593182

-
5CDS-intronENST00000254108ENST00000468127FUSchr16

31195705

+CREB3L2chr7

137590594

-
5CDS-intronENST00000254108ENST00000468127FUSchr16

31195705

+CREB3L2chr7

137593182

-
5CDS-intronENST00000254108ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000254108ENST00000468127FUSchr16

31196500

+CREB3L2chr

137593182

-
5CDS-intronENST00000254108ENST00000468127FUSchr16

31196500

+CREB3L2chr7

137593182

-
5CDS-intronENST00000380244ENST00000452463FUSchr16

31195705

+CREB3L2chr7

137590594

-
5CDS-intronENST00000380244ENST00000452463FUSchr16

31195705

+CREB3L2chr7

137593182

-
5CDS-intronENST00000380244ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000380244ENST00000452463FUSchr16

31196500

+CREB3L2chr

137593182

-
5CDS-intronENST00000380244ENST00000452463FUSchr16

31196500

+CREB3L2chr7

137593182

-
5CDS-intronENST00000380244ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000380244ENST00000458726FUSchr16

31195705

+CREB3L2chr7

137590594

-
5CDS-intronENST00000380244ENST00000458726FUSchr16

31195705

+CREB3L2chr7

137593182

-
5CDS-intronENST00000380244ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000380244ENST00000458726FUSchr16

31196500

+CREB3L2chr

137593182

-
5CDS-intronENST00000380244ENST00000458726FUSchr16

31196500

+CREB3L2chr7

137593182

-
5CDS-intronENST00000380244ENST00000468127FUSchr16

31195705

+CREB3L2chr7

137590594

-
5CDS-intronENST00000380244ENST00000468127FUSchr16

31195705

+CREB3L2chr7

137593182

-
5CDS-intronENST00000380244ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000380244ENST00000468127FUSchr16

31196500

+CREB3L2chr

137593182

-
5CDS-intronENST00000380244ENST00000468127FUSchr16

31196500

+CREB3L2chr7

137593182

-
5CDS-intronENST00000568685ENST00000452463FUSchr16

31195705

+CREB3L2chr7

137590594

-
5CDS-intronENST00000568685ENST00000452463FUSchr16

31195705

+CREB3L2chr7

137593182

-
5CDS-intronENST00000568685ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000568685ENST00000452463FUSchr16

31196500

+CREB3L2chr

137593182

-
5CDS-intronENST00000568685ENST00000452463FUSchr16

31196500

+CREB3L2chr7

137593182

-
5CDS-intronENST00000568685ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000568685ENST00000458726FUSchr16

31195705

+CREB3L2chr7

137590594

-
5CDS-intronENST00000568685ENST00000458726FUSchr16

31195705

+CREB3L2chr7

137593182

-
5CDS-intronENST00000568685ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000568685ENST00000458726FUSchr16

31196500

+CREB3L2chr

137593182

-
5CDS-intronENST00000568685ENST00000458726FUSchr16

31196500

+CREB3L2chr7

137593182

-
5CDS-intronENST00000568685ENST00000468127FUSchr16

31195705

+CREB3L2chr7

137590594

-
5CDS-intronENST00000568685ENST00000468127FUSchr16

31195705

+CREB3L2chr7

137593182

-
5CDS-intronENST00000568685ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137565145

-
5CDS-intronENST00000568685ENST00000468127FUSchr16

31196500

+CREB3L2chr

137593182

-
5CDS-intronENST00000568685ENST00000468127FUSchr16

31196500

+CREB3L2chr7

137593182

-
Frame-shiftENST00000254108ENST00000330387FUSchr16

31195705

+CREB3L2chr7

137590594

-
Frame-shiftENST00000254108ENST00000330387FUSchr16

31196500

+CREB3L2chr

137593182

-
Frame-shiftENST00000254108ENST00000330387FUSchr16

31196500

+CREB3L2chr7

137593182

-
Frame-shiftENST00000254108ENST00000456390FUSchr16

31195705

+CREB3L2chr7

137590594

-
Frame-shiftENST00000254108ENST00000456390FUSchr16

31196500

+CREB3L2chr

137593182

-
Frame-shiftENST00000254108ENST00000456390FUSchr16

31196500

+CREB3L2chr7

137593182

-
Frame-shiftENST00000380244ENST00000330387FUSchr16

31195705

+CREB3L2chr7

137590594

-
Frame-shiftENST00000380244ENST00000330387FUSchr16

31196500

+CREB3L2chr

137593182

-
Frame-shiftENST00000380244ENST00000330387FUSchr16

31196500

+CREB3L2chr7

137593182

-
Frame-shiftENST00000380244ENST00000456390FUSchr16

31195705

+CREB3L2chr7

137590594

-
Frame-shiftENST00000380244ENST00000456390FUSchr16

31196500

+CREB3L2chr

137593182

-
Frame-shiftENST00000380244ENST00000456390FUSchr16

31196500

+CREB3L2chr7

137593182

-
Frame-shiftENST00000568685ENST00000330387FUSchr16

31195705

+CREB3L2chr7

137590594

-
Frame-shiftENST00000568685ENST00000330387FUSchr16

31196500

+CREB3L2chr

137593182

-
Frame-shiftENST00000568685ENST00000330387FUSchr16

31196500

+CREB3L2chr7

137593182

-
Frame-shiftENST00000568685ENST00000456390FUSchr16

31195705

+CREB3L2chr7

137590594

-
Frame-shiftENST00000568685ENST00000456390FUSchr16

31196500

+CREB3L2chr

137593182

-
Frame-shiftENST00000568685ENST00000456390FUSchr16

31196500

+CREB3L2chr7

137593182

-
In-frameENST00000254108ENST00000330387FUSchr16

31195705

+CREB3L2chr7

137593182

-
In-frameENST00000254108ENST00000456390FUSchr16

31195705

+CREB3L2chr7

137593182

-
In-frameENST00000380244ENST00000330387FUSchr16

31195705

+CREB3L2chr7

137593182

-
In-frameENST00000380244ENST00000456390FUSchr16

31195705

+CREB3L2chr7

137593182

-
In-frameENST00000568685ENST00000330387FUSchr16

31195705

+CREB3L2chr7

137593182

-
In-frameENST00000568685ENST00000456390FUSchr16

31195705

+CREB3L2chr7

137593182

-
intron-3CDSENST00000474990ENST00000330387FUSchr16

31195705

+CREB3L2chr7

137590594

-
intron-3CDSENST00000474990ENST00000330387FUSchr16

31195705

+CREB3L2chr7

137593182

-
intron-3CDSENST00000474990ENST00000330387FUSchr16

31196500

+CREB3L2chr

137593182

-
intron-3CDSENST00000474990ENST00000330387FUSchr16

31196500

+CREB3L2chr7

137593182

-
intron-3CDSENST00000474990ENST00000456390FUSchr16

31195705

+CREB3L2chr7

137590594

-
intron-3CDSENST00000474990ENST00000456390FUSchr16

31195705

+CREB3L2chr7

137593182

-
intron-3CDSENST00000474990ENST00000456390FUSchr16

31196500

+CREB3L2chr

137593182

-
intron-3CDSENST00000474990ENST00000456390FUSchr16

31196500

+CREB3L2chr7

137593182

-
intron-3UTRENST00000254108ENST00000330387FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-3UTRENST00000380244ENST00000330387FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-3UTRENST00000474990ENST00000330387FUSchr16

31196384

+CREB3L2chr7

137565145

-
intron-3UTRENST00000474990ENST00000330387FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-3UTRENST00000568685ENST00000330387FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000254108ENST00000452463FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000254108ENST00000456390FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000254108ENST00000458726FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000254108ENST00000468127FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000380244ENST00000452463FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000380244ENST00000456390FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000380244ENST00000458726FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000380244ENST00000468127FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000474990ENST00000452463FUSchr16

31195705

+CREB3L2chr7

137590594

-
intron-intronENST00000474990ENST00000452463FUSchr16

31195705

+CREB3L2chr7

137593182

-
intron-intronENST00000474990ENST00000452463FUSchr16

31196384

+CREB3L2chr7

137565145

-
intron-intronENST00000474990ENST00000452463FUSchr16

31196500

+CREB3L2chr

137593182

-
intron-intronENST00000474990ENST00000452463FUSchr16

31196500

+CREB3L2chr7

137593182

-
intron-intronENST00000474990ENST00000452463FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000474990ENST00000456390FUSchr16

31196384

+CREB3L2chr7

137565145

-
intron-intronENST00000474990ENST00000456390FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000474990ENST00000458726FUSchr16

31195705

+CREB3L2chr7

137590594

-
intron-intronENST00000474990ENST00000458726FUSchr16

31195705

+CREB3L2chr7

137593182

-
intron-intronENST00000474990ENST00000458726FUSchr16

31196384

+CREB3L2chr7

137565145

-
intron-intronENST00000474990ENST00000458726FUSchr16

31196500

+CREB3L2chr

137593182

-
intron-intronENST00000474990ENST00000458726FUSchr16

31196500

+CREB3L2chr7

137593182

-
intron-intronENST00000474990ENST00000458726FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000474990ENST00000468127FUSchr16

31195705

+CREB3L2chr7

137590594

-
intron-intronENST00000474990ENST00000468127FUSchr16

31195705

+CREB3L2chr7

137593182

-
intron-intronENST00000474990ENST00000468127FUSchr16

31196384

+CREB3L2chr7

137565145

-
intron-intronENST00000474990ENST00000468127FUSchr16

31196500

+CREB3L2chr

137593182

-
intron-intronENST00000474990ENST00000468127FUSchr16

31196500

+CREB3L2chr7

137593182

-
intron-intronENST00000474990ENST00000468127FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000568685ENST00000452463FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000568685ENST00000456390FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000568685ENST00000458726FUSchr16

31199514

+CREB3L2chr7

137565145

-
intron-intronENST00000568685ENST00000468127FUSchr16

31199514

+CREB3L2chr7

137565145

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FUS-CREB3L2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FUS-CREB3L2


check button Go to

FGviewer for the breakpoints of chr16:31195705-chr7:137593182

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

CREB3L2

Q70SY1

FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.FUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52, ECO:0000269|PubMed:17178827}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FUS-CREB3L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FUS-CREB3L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FUS-CREB3L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FUS-CREB3L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
HgeneFUSC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
HgeneFUSC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneFUSC0497327Dementia1GENOMICS_ENGLAND
HgeneFUSC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
HgeneFUSC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET