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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FXR2-PTPRZ1 (FusionGDB2 ID:31779)

Fusion Gene Summary for FXR2-PTPRZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: FXR2-PTPRZ1
Fusion gene ID: 31779
HgeneTgene
Gene symbol

FXR2

PTPRZ1

Gene ID

9513

5803

Gene nameFMR1 autosomal homolog 2protein tyrosine phosphatase receptor type Z1
SynonymsFMR1L2|FXR2PHPTPZ|HPTPzeta|PTP-ZETA|PTP18|PTPRZ|PTPZ|R-PTP-zeta-2|RPTPB|RPTPbeta|phosphacan
Cytomap

17p13.1

7q31.32

Type of geneprotein-codingprotein-coding
Descriptionfragile X mental retardation syndrome-related protein 2fragile X mental retardation, autosomal homolog 2fragile X-mental retardation 1-like 2receptor-type tyrosine-protein phosphatase zetaprotein tyrosine phosphatase, receptor-type, Z polypeptide 1protein tyrosine phosphatase, receptor-type, zeta polypeptide 1protein-tyrosine phosphatase receptor type Z polypeptide 2receptor-type tyrosine
Modification date2020032720200313
UniProtAcc

P51116

.
Ensembl transtripts involved in fusion geneENST00000250113, ENST00000573057, 
ENST00000393386, ENST00000449182, 
ENST00000483028, 
Fusion gene scores* DoF score7 X 6 X 7=2949 X 8 X 4=288
# samples 711
** MAII scorelog2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FXR2 [Title/Abstract] AND PTPRZ1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFXR2(7507075)-PTPRZ1(121668606), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FXR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PTPRZ1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-1034-01AFXR2chr17

7507075

-PTPRZ1chr7

121668606

+


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Fusion Gene ORF analysis for FXR2-PTPRZ1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000250113ENST00000393386FXR2chr17

7507075

-PTPRZ1chr7

121668606

+
In-frameENST00000250113ENST00000449182FXR2chr17

7507075

-PTPRZ1chr7

121668606

+
5CDS-intronENST00000250113ENST00000483028FXR2chr17

7507075

-PTPRZ1chr7

121668606

+
intron-3CDSENST00000573057ENST00000393386FXR2chr17

7507075

-PTPRZ1chr7

121668606

+
intron-3CDSENST00000573057ENST00000449182FXR2chr17

7507075

-PTPRZ1chr7

121668606

+
intron-intronENST00000573057ENST00000483028FXR2chr17

7507075

-PTPRZ1chr7

121668606

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000250113FXR2chr177507075-ENST00000393386PTPRZ1chr7121668606+3560784382743901
ENST00000250113FXR2chr177507075-ENST00000449182PTPRZ1chr7121668606+2864784382722894

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000250113ENST00000393386FXR2chr177507075-PTPRZ1chr7121668606+0.0005750920.99942493
ENST00000250113ENST00000449182FXR2chr177507075-PTPRZ1chr7121668606+0.0016606390.9983393

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Fusion Genomic Features for FXR2-PTPRZ1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FXR2chr177507074-PTPRZ1chr7121668605+2.13E-070.99999976
FXR2chr177507074-PTPRZ1chr7121668605+2.13E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FXR2-PTPRZ1


check button Go to

FGviewer for the breakpoints of chr17:7507075-chr7:121668606

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FXR2

P51116

.
FUNCTION: RNA-binding protein.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFXR2chr17:7507075chr7:121668606ENST00000250113-51714_60149.66666666666666674.0DomainAgenet-like 1
HgeneFXR2chr17:7507075chr7:121668606ENST00000250113-51773_125149.66666666666666674.0DomainAgenet-like 2
TgenePTPRZ1chr17:7507075chr7:121668606ENST0000039338612301717_19921662.66666666666672316.0DomainTyrosine-protein phosphatase 1
TgenePTPRZ1chr17:7507075chr7:121668606ENST0000039338612302023_22821662.66666666666672316.0DomainTyrosine-protein phosphatase 2
TgenePTPRZ1chr17:7507075chr7:121668606ENST0000039338612301933_19391662.66666666666672316.0RegionSubstrate binding
TgenePTPRZ1chr17:7507075chr7:121668606ENST0000039338612301663_23151662.66666666666672316.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFXR2chr17:7507075chr7:121668606ENST00000250113-517414_418149.66666666666666674.0Compositional biasNote=Poly-Ser
HgeneFXR2chr17:7507075chr7:121668606ENST00000250113-517544_552149.66666666666666674.0Compositional biasNote=Poly-Arg
HgeneFXR2chr17:7507075chr7:121668606ENST00000250113-517584_594149.66666666666666674.0Compositional biasNote=Poly-Arg
HgeneFXR2chr17:7507075chr7:121668606ENST00000250113-517232_261149.66666666666666674.0DomainKH 1
HgeneFXR2chr17:7507075chr7:121668606ENST00000250113-517295_324149.66666666666666674.0DomainKH 2
TgenePTPRZ1chr17:7507075chr7:121668606ENST000003933861230314_4131662.66666666666672316.0DomainFibronectin type-III
TgenePTPRZ1chr17:7507075chr7:121668606ENST00000393386123036_3001662.66666666666672316.0DomainAlpha-carbonic anhydrase
TgenePTPRZ1chr17:7507075chr7:121668606ENST00000393386123025_16361662.66666666666672316.0Topological domainExtracellular
TgenePTPRZ1chr17:7507075chr7:121668606ENST0000039338612301637_16621662.66666666666672316.0TransmembraneHelical


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Fusion Gene Sequence for FXR2-PTPRZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000250113_ENST00000393386_TCGA-14-1034-01A_FXR2_chr17_7507075_-_PTPRZ1_chr7_121668606_length(transcript)=3560nt_BP=784nt
AGGCTGTGGAGCGGCAGCGGCAGCAGCGGGTCCCGGGACTGAGGCAGCAGCGGGGGCGGCGGCGGGCGGAAGCTGAGGTGACGAAGGCAG
CGGCGGCGGCGGCCGTTTCCCTCACGGTGGCGGAGACCAAGGCGGCGGCGGCGGACGGGGAGCGGCCCGGCCCCGGCCCCCTGCTCGTTG
GCTGTGGCAGGGCCGCCGTGGGGCCGGCCCGGCTCCCGCCCCCCGCGGCTCCCCCTCCGGCTCCTCCTCCGGGGAGACGCCGGGGGCCTG
GCCCGGCCCGCACTCAGACTGCTGCTGCAGCCGCCGCCGGGGGAGTCGGAGGCGGTGGCGGCGCCATGGGCGGCCTGGCCTCTGGGGGGG
ATGTGGAGCCGGGACTGCCCGTCGAGGTGCGCGGCTCCAACGGGGCCTTCTACAAGGGCTTTGTGAAGGATGTCCATGAAGACTCTGTCA
CCATCTTCTTTGAAAACAACTGGCAGAGTGAGAGACAAATTCCTTTTGGGGATGTCCGGCTACCACCTCCAGCTGACTATAATAAGGAGA
TCACAGAAGGGGATGAAGTGGAGGTTTATTCTCGAGCCAATGAACAGGAACCTTGTGGCTGGTGGCTGGCCCGGGTGCGGATGATGAAGG
GAGATTTCTATGTCATTGAATATGCTGCCTGTGATGCCACCTACAATGAAATTGTTACCCTGGAGCGACTTCGGCCAGTTAATCCCAATC
CCCTTGCAACCAAAGGCAGCTTCTTCAAGGTTACCATGGCTGTGCCCGAGGATCTGAGAGAAGCGAAATGCTTCCAGACTGCACACTTTT
ACTTAGAGGACAGTACATCCCCTAGAGTTATATCCACACCTCCAACACCTATCTTTCCAATTTCAGATGATGTCGGAGCAATTCCAATAA
AGCACTTTCCAAAGCATGTTGCAGATTTACATGCAAGTAGTGGGTTTACTGAAGAATTTGAGACACTGAAAGAGTTTTACCAGGAAGTGC
AGAGCTGTACTGTTGACTTAGGTATTACAGCAGACAGCTCCAACCACCCAGACAACAAGCACAAGAATCGATACATAAATATCGTTGCCT
ATGATCATAGCAGGGTTAAGCTAGCACAGCTTGCTGAAAAGGATGGCAAACTGACTGATTATATCAATGCCAATTATGTTGATGGCTACA
ACAGACCAAAAGCTTATATTGCTGCCCAAGGCCCACTGAAATCCACAGCTGAAGATTTCTGGAGAATGATATGGGAACATAATGTGGAAG
TTATTGTCATGATAACAAACCTCGTGGAGAAAGGAAGGAGAAAATGTGATCAGTACTGGCCTGCCGATGGGAGTGAGGAGTACGGGAACT
TTCTGGTCACTCAGAAGAGTGTGCAAGTGCTTGCCTATTATACTGTGAGGAATTTTACTCTAAGAAACACAAAAATAAAAAAGGGCTCCC
AGAAAGGAAGACCCAGTGGACGTGTGGTCACACAGTATCACTACACGCAGTGGCCTGACATGGGAGTACCAGAGTACTCCCTGCCAGTGC
TGACCTTTGTGAGAAAGGCAGCCTATGCCAAGCGCCATGCAGTGGGGCCTGTTGTCGTCCACTGCAGTGCTGGAGTTGGAAGAACAGGCA
CATATATTGTGCTAGACAGTATGTTGCAGCAGATTCAACACGAAGGAACTGTCAACATATTTGGCTTCTTAAAACACATCCGTTCACAAA
GAAATTATTTGGTACAAACTGAGGAGCAATATGTCTTCATTCATGATACACTGGTTGAGGCCATACTTAGTAAAGAAACTGAGGTGCTGG
ACAGTCATATTCATGCCTATGTTAATGCACTCCTCATTCCTGGACCAGCAGGCAAAACAAAGCTAGAGAAACAATTCCAGCTCCTGAGCC
AGTCAAATATACAGCAGAGTGACTATTCTGCAGCCCTAAAGCAATGCAACAGGGAAAAGAATCGAACTTCTTCTATCATCCCTGTGGAAA
GATCAAGGGTTGGCATTTCATCCCTGAGTGGAGAAGGCACAGACTACATCAATGCCTCCTATATCATGGGCTATTACCAGAGCAATGAAT
TCATCATTACCCAGCACCCTCTCCTTCATACCATCAAGGATTTCTGGAGGATGATATGGGACCATAATGCCCAACTGGTGGTTATGATTC
CTGATGGCCAAAACATGGCAGAAGATGAATTTGTTTACTGGCCAAATAAAGATGAGCCTATAAATTGTGAGAGCTTTAAGGTCACTCTTA
TGGCTGAAGAACACAAATGTCTATCTAATGAGGAAAAACTTATAATTCAGGACTTTATCTTAGAAGCTACACAGGATGATTATGTACTTG
AAGTGAGGCACTTTCAGTGTCCTAAATGGCCAAATCCAGATAGCCCCATTAGTAAAACTTTTGAACTTATAAGTGTTATAAAAGAAGAAG
CTGCCAATAGGGATGGGCCTATGATTGTTCATGATGAGCATGGAGGAGTGACGGCAGGAACTTTCTGTGCTCTGACAACCCTTATGCACC
AACTAGAAAAAGAAAATTCCGTGGATGTTTACCAGGTAGCCAAGATGATCAATCTGATGAGGCCAGGAGTCTTTGCTGACATTGAGCAGT
ATCAGTTTCTCTACAAAGTGATCCTCAGCCTTGTGAGCACAAGGCAGGAAGAGAATCCATCCACCTCTCTGGACAGTAATGGTGCAGCAT
TGCCTGATGGAAATATAGCTGAGAGCTTAGAGTCTTTAGTTTAACACAGAAAGGGGTGGGGGAACTCACATCTGAGCATTGTTTTCCTCT
TCCTAAAATTAGGCAGGAAAATCAGTCTAGTTCTGTTATCTGTTGATTTCCCATCACCTGACAGTAACTTTCATGACATAGGATTCTGCC
GCCAAATTTATATCATTAACAATGTGTGCCTTTTTGCAAGACTTGTAATTTACTTATTATGTTTGAACTAAAATGATTGAATTTTACAGT
ATTTCTAAGAATGGAATTGTGGTATTTTTTTCTGTATTGATTTTAACAGAAAATTTCAATTTATAGAGGTTAGGAATTCCAAACTACAGA
AAATGTTTGTTTTTAGTGTCAAATTTTTAGCTGTATTTGTAGCAATTATCAGGTTTGCTAGAAATATAACTTTTAATACAGTAGCCTGTA
AATAAAACACTCTTCCATATGATATTCAACATTTTACAACTGCAGTATTCACCTAAAGTAGAAATAATCTGTTACTTATTGTAAATACTG
CCCTAGTGTCTCCATGGACCAAATTTATATTTATAATTGTAGATTTTTATATTTTACTACTGAGTCAAGTTTTCTAGTTCTGTGTAATTG
TTTAGTTTAATGACGTAGTTCATTAGCTGGTCTTACTCTACCAGTTTTCTGACATTGTATTGTGTTACCTAAGTCATTAACTTTGTTTCA
GCATGTAATTTTAACTTTTGTGGAAAATAGAAATACCTTCATTTTGAAAGAAGTTTTTATGAGAATAACACCTTACCAAACATTGTTCAA

>In-frame_ENST00000250113_ENST00000393386_TCGA-14-1034-01A_FXR2_chr17_7507075_-_PTPRZ1_chr7_121668606_length(amino acids)=901AA_start in transcript=38_stop in transcript=2743
MRQQRGRRRAEAEVTKAAAAAAVSLTVAETKAAAADGERPGPGPLLVGCGRAAVGPARLPPPAAPPPAPPPGRRRGPGPARTQTAAAAAA
GGVGGGGGAMGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRA
NEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREAKCFQTAHFYLEDSTSPRVIST
PPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAE
KDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAY
YTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQ
HEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAAL
KQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVY
WPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDE
HGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALPDGNIAESLESL

--------------------------------------------------------------
>In-frame_ENST00000250113_ENST00000449182_TCGA-14-1034-01A_FXR2_chr17_7507075_-_PTPRZ1_chr7_121668606_length(transcript)=2864nt_BP=784nt
AGGCTGTGGAGCGGCAGCGGCAGCAGCGGGTCCCGGGACTGAGGCAGCAGCGGGGGCGGCGGCGGGCGGAAGCTGAGGTGACGAAGGCAG
CGGCGGCGGCGGCCGTTTCCCTCACGGTGGCGGAGACCAAGGCGGCGGCGGCGGACGGGGAGCGGCCCGGCCCCGGCCCCCTGCTCGTTG
GCTGTGGCAGGGCCGCCGTGGGGCCGGCCCGGCTCCCGCCCCCCGCGGCTCCCCCTCCGGCTCCTCCTCCGGGGAGACGCCGGGGGCCTG
GCCCGGCCCGCACTCAGACTGCTGCTGCAGCCGCCGCCGGGGGAGTCGGAGGCGGTGGCGGCGCCATGGGCGGCCTGGCCTCTGGGGGGG
ATGTGGAGCCGGGACTGCCCGTCGAGGTGCGCGGCTCCAACGGGGCCTTCTACAAGGGCTTTGTGAAGGATGTCCATGAAGACTCTGTCA
CCATCTTCTTTGAAAACAACTGGCAGAGTGAGAGACAAATTCCTTTTGGGGATGTCCGGCTACCACCTCCAGCTGACTATAATAAGGAGA
TCACAGAAGGGGATGAAGTGGAGGTTTATTCTCGAGCCAATGAACAGGAACCTTGTGGCTGGTGGCTGGCCCGGGTGCGGATGATGAAGG
GAGATTTCTATGTCATTGAATATGCTGCCTGTGATGCCACCTACAATGAAATTGTTACCCTGGAGCGACTTCGGCCAGTTAATCCCAATC
CCCTTGCAACCAAAGGCAGCTTCTTCAAGGTTACCATGGCTGTGCCCGAGGATCTGAGAGAAGCGAAATGCTTCCAGACTGCACACTTTT
ACTTAGAGGACAGTACATCCCCTAGAGTTATATCCACACCTCCAACACCTATCTTTCCAATTTCAGATGATGTCGGAGCAATTCCAATAA
AGCACTTTCCAAAGCATGTTGCAGATTTACATGCAAGTAGTGGGTTTACTGAAGAATTTGAGGAAGTGCAGAGCTGTACTGTTGACTTAG
GTATTACAGCAGACAGCTCCAACCACCCAGACAACAAGCACAAGAATCGATACATAAATATCGTTGCCTATGATCATAGCAGGGTTAAGC
TAGCACAGCTTGCTGAAAAGGATGGCAAACTGACTGATTATATCAATGCCAATTATGTTGATGGCTACAACAGACCAAAAGCTTATATTG
CTGCCCAAGGCCCACTGAAATCCACAGCTGAAGATTTCTGGAGAATGATATGGGAACATAATGTGGAAGTTATTGTCATGATAACAAACC
TCGTGGAGAAAGGAAGGAGAAAATGTGATCAGTACTGGCCTGCCGATGGGAGTGAGGAGTACGGGAACTTTCTGGTCACTCAGAAGAGTG
TGCAAGTGCTTGCCTATTATACTGTGAGGAATTTTACTCTAAGAAACACAAAAATAAAAAAGGGCTCCCAGAAAGGAAGACCCAGTGGAC
GTGTGGTCACACAGTATCACTACACGCAGTGGCCTGACATGGGAGTACCAGAGTACTCCCTGCCAGTGCTGACCTTTGTGAGAAAGGCAG
CCTATGCCAAGCGCCATGCAGTGGGGCCTGTTGTCGTCCACTGCAGTGCTGGAGTTGGAAGAACAGGCACATATATTGTGCTAGACAGTA
TGTTGCAGCAGATTCAACACGAAGGAACTGTCAACATATTTGGCTTCTTAAAACACATCCGTTCACAAAGAAATTATTTGGTACAAACTG
AGGAGCAATATGTCTTCATTCATGATACACTGGTTGAGGCCATACTTAGTAAAGAAACTGAGGTGCTGGACAGTCATATTCATGCCTATG
TTAATGCACTCCTCATTCCTGGACCAGCAGGCAAAACAAAGCTAGAGAAACAATTCCAGCTCCTGAGCCAGTCAAATATACAGCAGAGTG
ACTATTCTGCAGCCCTAAAGCAATGCAACAGGGAAAAGAATCGAACTTCTTCTATCATCCCTGTGGAAAGATCAAGGGTTGGCATTTCAT
CCCTGAGTGGAGAAGGCACAGACTACATCAATGCCTCCTATATCATGGGCTATTACCAGAGCAATGAATTCATCATTACCCAGCACCCTC
TCCTTCATACCATCAAGGATTTCTGGAGGATGATATGGGACCATAATGCCCAACTGGTGGTTATGATTCCTGATGGCCAAAACATGGCAG
AAGATGAATTTGTTTACTGGCCAAATAAAGATGAGCCTATAAATTGTGAGAGCTTTAAGGTCACTCTTATGGCTGAAGAACACAAATGTC
TATCTAATGAGGAAAAACTTATAATTCAGGACTTTATCTTAGAAGCTACACAGGATGATTATGTACTTGAAGTGAGGCACTTTCAGTGTC
CTAAATGGCCAAATCCAGATAGCCCCATTAGTAAAACTTTTGAACTTATAAGTGTTATAAAAGAAGAAGCTGCCAATAGGGATGGGCCTA
TGATTGTTCATGATGAGCATGGAGGAGTGACGGCAGGAACTTTCTGTGCTCTGACAACCCTTATGCACCAACTAGAAAAAGAAAATTCCG
TGGATGTTTACCAGGTAGCCAAGATGATCAATCTGATGAGGCCAGGAGTCTTTGCTGACATTGAGCAGTATCAGTTTCTCTACAAAGTGA
TCCTCAGCCTTGTGAGCACAAGGCAGGAAGAGAATCCATCCACCTCTCTGGACAGTAATGGTGCAGCATTGCCTGATGGAAATATAGCTG
AGAGCTTAGAGTCTTTAGTTTAACACAGAAAGGGGTGGGGGAACTCACATCTGAGCATTGTTTTCCTCTTCCTAAAATTAGGCAGGAAAA

>In-frame_ENST00000250113_ENST00000449182_TCGA-14-1034-01A_FXR2_chr17_7507075_-_PTPRZ1_chr7_121668606_length(amino acids)=894AA_start in transcript=38_stop in transcript=2722
MRQQRGRRRAEAEVTKAAAAAAVSLTVAETKAAAADGERPGPGPLLVGCGRAAVGPARLPPPAAPPPAPPPGRRRGPGPARTQTAAAAAA
GGVGGGGGAMGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRA
NEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREAKCFQTAHFYLEDSTSPRVIST
PPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFEEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTD
YINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFT
LRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNI
FGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREK
NRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEP
INCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAG

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Fusion Gene PPI Analysis for FXR2-PTPRZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FXR2-PTPRZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FXR2-PTPRZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRZ1C0036341Schizophrenia3PSYGENET
TgenePTPRZ1C0004681Bagassosis1CTD_human
TgenePTPRZ1C0032273Pneumoconiosis1CTD_human
TgenePTPRZ1C0079487Helicobacter Infections1CTD_human
TgenePTPRZ1C1838332HELICOBACTER PYLORI INFECTION, SUSCEPTIBILITY TO1GENOMICS_ENGLAND