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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FXR2-TP53 (FusionGDB2 ID:31781)

Fusion Gene Summary for FXR2-TP53

check button Fusion gene summary
Fusion gene informationFusion gene name: FXR2-TP53
Fusion gene ID: 31781
HgeneTgene
Gene symbol

FXR2

TP53

Gene ID

9513

7157

Gene nameFMR1 autosomal homolog 2tumor protein p53
SynonymsFMR1L2|FXR2PBCC7|BMFS5|LFS1|P53|TRP53
Cytomap

17p13.1

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionfragile X mental retardation syndrome-related protein 2fragile X mental retardation, autosomal homolog 2fragile X-mental retardation 1-like 2cellular tumor antigen p53antigen NY-CO-13mutant tumor protein 53p53 tumor suppressorphosphoprotein p53transformation-related protein 53tumor protein 53tumor supressor p53
Modification date2020032720200329
UniProtAcc

P51116

Q12888

Ensembl transtripts involved in fusion geneENST00000250113, ENST00000573057, 
ENST00000413465, ENST00000359597, 
ENST00000269305, ENST00000455263, 
ENST00000420246, ENST00000445888, 
ENST00000574684, 
Fusion gene scores* DoF score7 X 6 X 7=2947 X 7 X 4=196
# samples 79
** MAII scorelog2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FXR2 [Title/Abstract] AND TP53 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFXR2(7504727)-TP53(7577608), # samples:3
TP53(7573926)-FXR2(7499312), # samples:1
TP53(7579311)-FXR2(7509467), # samples:1
Anticipated loss of major functional domain due to fusion event.TP53-FXR2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TP53-FXR2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TP53-FXR2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TP53-FXR2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TP53-FXR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TP53-FXR2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TP53-FXR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTP53

GO:0000733

DNA strand renaturation

8183576

TgeneTP53

GO:0006355

regulation of transcription, DNA-templated

7587074

TgeneTP53

GO:0006974

cellular response to DNA damage stimulus

14744935|15710329|17938203

TgeneTP53

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

16213212

TgeneTP53

GO:0006983

ER overload response

14744935

TgeneTP53

GO:0007050

cell cycle arrest

15149599

TgeneTP53

GO:0008104

protein localization

16507995

TgeneTP53

GO:0008285

negative regulation of cell proliferation

22783376

TgeneTP53

GO:0010628

positive regulation of gene expression

15314173|20332243

TgeneTP53

GO:0030330

DNA damage response, signal transduction by p53 class mediator

15149599

TgeneTP53

GO:0031497

chromatin assembly

16322561

TgeneTP53

GO:0034644

cellular response to UV

16213212|23629966

TgeneTP53

GO:0036003

positive regulation of transcription from RNA polymerase II promoter in response to stress

30089260

TgeneTP53

GO:0042149

cellular response to glucose starvation

14744935|21471221

TgeneTP53

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

14654789|14744935|17403783

TgeneTP53

GO:0042981

regulation of apoptotic process

14744935

TgeneTP53

GO:0043065

positive regulation of apoptotic process

12667443|15565177|20959462

TgeneTP53

GO:0045892

negative regulation of transcription, DNA-templated

24051492

TgeneTP53

GO:0045893

positive regulation of transcription, DNA-templated

16322561|17403783|18549481|20378837

TgeneTP53

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

24289924

TgeneTP53

GO:0045944

positive regulation of transcription by RNA polymerase II

11672523|17145718|17310983|17599062|18549481|20959462|24652652

TgeneTP53

GO:0051123

RNA polymerase II preinitiation complex assembly

24289924

TgeneTP53

GO:0051974

negative regulation of telomerase activity

10597287

TgeneTP53

GO:0065003

protein-containing complex assembly

12915590

TgeneTP53

GO:0071158

positive regulation of cell cycle arrest

15314173

TgeneTP53

GO:0071480

cellular response to gamma radiation

16213212

TgeneTP53

GO:0072331

signal transduction by p53 class mediator

15314173

TgeneTP53

GO:0072717

cellular response to actinomycin D

15314173

TgeneTP53

GO:0090200

positive regulation of release of cytochrome c from mitochondria

14963330

TgeneTP53

GO:0097252

oligodendrocyte apoptotic process

7720704

TgeneTP53

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

20546595

TgeneTP53

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

26100857

TgeneTP53

GO:1990248

regulation of transcription from RNA polymerase II promoter in response to DNA damage

30089260


check buttonFusion gene breakpoints across FXR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TP53 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-YU-AA61-01AFXR2chr17

7504727

-TP53chr17

7577608

-
ChimerDB4TGCTTCGA-YU-AA61FXR2chr17

7504727

-TP53chr17

7577608

-
ChimerDB4TGCTTCGA-YU-AA61-01AFXR2chr17

7504727

-TP53chr17

7577608

-


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Fusion Gene ORF analysis for FXR2-TP53

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000250113ENST00000413465FXR2chr17

7504727

-TP53chr17

7577608

-
In-frameENST00000250113ENST00000359597FXR2chr17

7504727

-TP53chr17

7577608

-
In-frameENST00000250113ENST00000269305FXR2chr17

7504727

-TP53chr17

7577608

-
In-frameENST00000250113ENST00000455263FXR2chr17

7504727

-TP53chr17

7577608

-
In-frameENST00000250113ENST00000420246FXR2chr17

7504727

-TP53chr17

7577608

-
In-frameENST00000250113ENST00000445888FXR2chr17

7504727

-TP53chr17

7577608

-
5CDS-5UTRENST00000250113ENST00000574684FXR2chr17

7504727

-TP53chr17

7577608

-
intron-3CDSENST00000573057ENST00000413465FXR2chr17

7504727

-TP53chr17

7577608

-
intron-3CDSENST00000573057ENST00000359597FXR2chr17

7504727

-TP53chr17

7577608

-
intron-3CDSENST00000573057ENST00000269305FXR2chr17

7504727

-TP53chr17

7577608

-
intron-3CDSENST00000573057ENST00000455263FXR2chr17

7504727

-TP53chr17

7577608

-
intron-3CDSENST00000573057ENST00000420246FXR2chr17

7504727

-TP53chr17

7577608

-
intron-3CDSENST00000573057ENST00000445888FXR2chr17

7504727

-TP53chr17

7577608

-
intron-5UTRENST00000573057ENST00000574684FXR2chr17

7504727

-TP53chr17

7577608

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FXR2-TP53


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FXR2-TP53


check button Go to

FGviewer for the breakpoints of chr17:7504727-chr17:7577608

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FXR2

P51116

TP53

Q12888

FUNCTION: RNA-binding protein.FUNCTION: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:27153538, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306, PubMed:27153538). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:27153538, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112). {ECO:0000250|UniProtKB:P70399, ECO:0000269|PubMed:12364621, ECO:0000269|PubMed:17190600, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22553214, ECO:0000269|PubMed:23333306, ECO:0000269|PubMed:23345425, ECO:0000269|PubMed:23727112, ECO:0000269|PubMed:23760478, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:28241136}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFXR2chr17:7504727chr17:7577608ENST00000250113-71714_60220.0674.0DomainAgenet-like 1
HgeneFXR2chr17:7504727chr17:7577608ENST00000250113-71773_125220.0674.0DomainAgenet-like 2
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511305_321224.0394.0MotifNote=Bipartite nuclear localization signal
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511339_350224.0394.0MotifNote=Nuclear export signal
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511370_372224.0394.0MotifNote=[KR]-[STA]-K motif
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512305_321224.0774.6666666666666MotifNote=Bipartite nuclear localization signal
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512339_350224.0774.6666666666666MotifNote=Nuclear export signal
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512370_372224.0774.6666666666666MotifNote=[KR]-[STA]-K motif
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511305_321224.0394.0MotifNote=Bipartite nuclear localization signal
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511339_350224.0394.0MotifNote=Nuclear export signal
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511370_372224.0394.0MotifNote=[KR]-[STA]-K motif
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512305_321224.0755.3333333333334MotifNote=Bipartite nuclear localization signal
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512339_350224.0755.3333333333334MotifNote=Nuclear export signal
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512370_372224.0755.3333333333334MotifNote=[KR]-[STA]-K motif
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511325_356224.0394.0RegionNote=Oligomerization
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511368_387224.0394.0RegionNote=Basic (repression of DNA-binding)
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512325_356224.0774.6666666666666RegionNote=Oligomerization
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512368_387224.0774.6666666666666RegionNote=Basic (repression of DNA-binding)
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511325_356224.0394.0RegionNote=Oligomerization
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511368_387224.0394.0RegionNote=Basic (repression of DNA-binding)
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512325_356224.0755.3333333333334RegionNote=Oligomerization
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512368_387224.0755.3333333333334RegionNote=Basic (repression of DNA-binding)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFXR2chr17:7504727chr17:7577608ENST00000250113-717414_418220.0674.0Compositional biasNote=Poly-Ser
HgeneFXR2chr17:7504727chr17:7577608ENST00000250113-717544_552220.0674.0Compositional biasNote=Poly-Arg
HgeneFXR2chr17:7504727chr17:7577608ENST00000250113-717584_594220.0674.0Compositional biasNote=Poly-Arg
HgeneFXR2chr17:7504727chr17:7577608ENST00000250113-717232_261220.0674.0DomainKH 1
HgeneFXR2chr17:7504727chr17:7577608ENST00000250113-717295_324220.0674.0DomainKH 2
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511102_292224.0394.0DNA binding.
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512102_292224.0774.6666666666666DNA binding.
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511102_292224.0394.0DNA binding.
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512102_292224.0755.3333333333334DNA binding.
TgeneTP53chr17:7504727chr17:7577608ENST0000026930551117_25224.0394.0MotifNote=TADI
TgeneTP53chr17:7504727chr17:7577608ENST0000026930551148_56224.0394.0MotifNote=TADII
TgeneTP53chr17:7504727chr17:7577608ENST0000042024651217_25224.0774.6666666666666MotifNote=TADI
TgeneTP53chr17:7504727chr17:7577608ENST0000042024651248_56224.0774.6666666666666MotifNote=TADII
TgeneTP53chr17:7504727chr17:7577608ENST0000044588851117_25224.0394.0MotifNote=TADI
TgeneTP53chr17:7504727chr17:7577608ENST0000044588851148_56224.0394.0MotifNote=TADII
TgeneTP53chr17:7504727chr17:7577608ENST0000045526351217_25224.0755.3333333333334MotifNote=TADI
TgeneTP53chr17:7504727chr17:7577608ENST0000045526351248_56224.0755.3333333333334MotifNote=TADII
TgeneTP53chr17:7504727chr17:7577608ENST000002693055111_44224.0394.0RegionNote=Transcription activation (acidic)
TgeneTP53chr17:7504727chr17:7577608ENST000004202465121_44224.0774.6666666666666RegionNote=Transcription activation (acidic)
TgeneTP53chr17:7504727chr17:7577608ENST000004458885111_44224.0394.0RegionNote=Transcription activation (acidic)
TgeneTP53chr17:7504727chr17:7577608ENST000004552635121_44224.0755.3333333333334RegionNote=Transcription activation (acidic)


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Fusion Gene Sequence for FXR2-TP53


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FXR2-TP53


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511300_393224.0394.0CARM1
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512300_393224.0774.6666666666666CARM1
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511300_393224.0394.0CARM1
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512300_393224.0755.3333333333334CARM1
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511273_280224.0394.0DNA
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512273_280224.0774.6666666666666DNA
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511273_280224.0394.0DNA
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512273_280224.0755.3333333333334DNA
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511256_294224.0394.0E4F1
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512256_294224.0774.6666666666666E4F1
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511256_294224.0394.0E4F1
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512256_294224.0755.3333333333334E4F1
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511319_360224.0394.0HIPK2
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512319_360224.0774.6666666666666HIPK2
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511319_360224.0394.0HIPK2
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512319_360224.0755.3333333333334HIPK2
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511241_248224.0394.0the 53BP2 SH3 domain
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512241_248224.0774.6666666666666the 53BP2 SH3 domain
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511241_248224.0394.0the 53BP2 SH3 domain
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512241_248224.0755.3333333333334the 53BP2 SH3 domain
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511359_363224.0394.0USP7
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512359_363224.0774.6666666666666USP7
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511359_363224.0394.0USP7
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512359_363224.0755.3333333333334USP7


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511116_292224.0394.0AXIN1
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512116_292224.0774.6666666666666AXIN1
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511116_292224.0394.0AXIN1
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512116_292224.0755.3333333333334AXIN1
TgeneTP53chr17:7504727chr17:7577608ENST000002693055111_320224.0394.0CCAR2
TgeneTP53chr17:7504727chr17:7577608ENST000004202465121_320224.0774.6666666666666CCAR2
TgeneTP53chr17:7504727chr17:7577608ENST000004458885111_320224.0394.0CCAR2
TgeneTP53chr17:7504727chr17:7577608ENST000004552635121_320224.0755.3333333333334CCAR2
TgeneTP53chr17:7504727chr17:7577608ENST00000269305511100_370224.0394.0HIPK1
TgeneTP53chr17:7504727chr17:7577608ENST00000420246512100_370224.0774.6666666666666HIPK1
TgeneTP53chr17:7504727chr17:7577608ENST00000445888511100_370224.0394.0HIPK1
TgeneTP53chr17:7504727chr17:7577608ENST00000455263512100_370224.0755.3333333333334HIPK1
TgeneTP53chr17:7504727chr17:7577608ENST000002693055111_83224.0394.0HRMT1L2
TgeneTP53chr17:7504727chr17:7577608ENST000004202465121_83224.0774.6666666666666HRMT1L2
TgeneTP53chr17:7504727chr17:7577608ENST000004458885111_83224.0394.0HRMT1L2
TgeneTP53chr17:7504727chr17:7577608ENST000004552635121_83224.0755.3333333333334HRMT1L2
TgeneTP53chr17:7504727chr17:7577608ENST0000026930551166_110224.0394.0WWOX
TgeneTP53chr17:7504727chr17:7577608ENST0000042024651266_110224.0774.6666666666666WWOX
TgeneTP53chr17:7504727chr17:7577608ENST0000044588851166_110224.0394.0WWOX
TgeneTP53chr17:7504727chr17:7577608ENST0000045526351266_110224.0755.3333333333334WWOX


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FXR2-TP53


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FXR2-TP53


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTP53C0085390Li-Fraumeni Syndrome22CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTP53C0009402Colorectal Carcinoma8CTD_human;GENOMICS_ENGLAND
TgeneTP53C0009404Colorectal Neoplasms8CTD_human
TgeneTP53C0033578Prostatic Neoplasms8CTD_human
TgeneTP53C0376358Malignant neoplasm of prostate8CTD_human
TgeneTP53C0006142Malignant neoplasm of breast6CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTP53C0023434Chronic Lymphocytic Leukemia6CGI;CTD_human;ORPHANET
TgeneTP53C0678222Breast Carcinoma6CGI;CTD_human
TgeneTP53C1257931Mammary Neoplasms, Human6CTD_human
TgeneTP53C1458155Mammary Neoplasms6CTD_human
TgeneTP53C2239176Liver carcinoma6CGI;CTD_human;GENOMICS_ENGLAND
TgeneTP53C4704874Mammary Carcinoma, Human6CTD_human
TgeneTP53C0005684Malignant neoplasm of urinary bladder5CTD_human
TgeneTP53C0005695Bladder Neoplasm5CTD_human
TgeneTP53C0024121Lung Neoplasms5CGI;CTD_human
TgeneTP53C0206686Adrenocortical carcinoma5CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneTP53C0242379Malignant neoplasm of lung5CGI;CTD_human
TgeneTP53C0855095Small Lymphocytic Lymphoma5ORPHANET
TgeneTP53C1868683B-CELL MALIGNANCY, LOW-GRADE5ORPHANET
TgeneTP53C0007131Non-Small Cell Lung Carcinoma4CTD_human
TgeneTP53C0007134Renal Cell Carcinoma4CTD_human
TgeneTP53C0025202melanoma4CGI;CTD_human
TgeneTP53C0029463Osteosarcoma4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneTP53C0279702Conventional (Clear Cell) Renal Cell Carcinoma4CTD_human
TgeneTP53C1266042Chromophobe Renal Cell Carcinoma4CTD_human
TgeneTP53C1266043Sarcomatoid Renal Cell Carcinoma4CTD_human
TgeneTP53C1266044Collecting Duct Carcinoma of the Kidney4CTD_human
TgeneTP53C1306837Papillary Renal Cell Carcinoma4CTD_human
TgeneTP53C0001418Adenocarcinoma3CTD_human
TgeneTP53C0007102Malignant tumor of colon3CTD_human
TgeneTP53C0009375Colonic Neoplasms3CTD_human
TgeneTP53C0017638Glioma3CGI;CTD_human
TgeneTP53C0040028Thrombocythemia, Essential3ORPHANET
TgeneTP53C0149925Small cell carcinoma of lung3CTD_human;ORPHANET
TgeneTP53C0205641Adenocarcinoma, Basal Cell3CTD_human
TgeneTP53C0205642Adenocarcinoma, Oxyphilic3CTD_human
TgeneTP53C0205643Carcinoma, Cribriform3CTD_human
TgeneTP53C0205644Carcinoma, Granular Cell3CTD_human
TgeneTP53C0205645Adenocarcinoma, Tubular3CTD_human
TgeneTP53C0259783mixed gliomas3CTD_human
TgeneTP53C0555198Malignant Glioma3CTD_human
TgeneTP53C1368275Pigmented Basal Cell Carcinoma3CTD_human
TgeneTP53C4721806Carcinoma, Basal Cell3CTD_human
TgeneTP53C0001969Alcoholic Intoxication2PSYGENET
TgeneTP53C0001973Alcoholic Intoxication, Chronic2PSYGENET
TgeneTP53C0007097Carcinoma2CTD_human
TgeneTP53C0007137Squamous cell carcinoma2CTD_human
TgeneTP53C0014859Esophageal Neoplasms2CTD_human
TgeneTP53C0016978gallbladder neoplasm2CTD_human
TgeneTP53C0022593Keratosis2CTD_human
TgeneTP53C0022594Keratosis Blennorrhagica2CTD_human
TgeneTP53C0023903Liver neoplasms2CTD_human
TgeneTP53C0024623Malignant neoplasm of stomach2CTD_human
TgeneTP53C0036920Sezary Syndrome2CTD_human
TgeneTP53C0038356Stomach Neoplasms2CTD_human
TgeneTP53C0086501Keratoma2CTD_human
TgeneTP53C0153452Malignant neoplasm of gallbladder2CTD_human
TgeneTP53C0205696Anaplastic carcinoma2CTD_human
TgeneTP53C0205697Carcinoma, Spindle-Cell2CTD_human
TgeneTP53C0205698Undifferentiated carcinoma2CTD_human
TgeneTP53C0205699Carcinomatosis2CTD_human
TgeneTP53C0274861Arsenic Poisoning, Inorganic2CTD_human
TgeneTP53C0274862Nervous System, Organic Arsenic Poisoning2CTD_human
TgeneTP53C0311375Arsenic Poisoning2CTD_human
TgeneTP53C0345904Malignant neoplasm of liver2CTD_human
TgeneTP53C0546837Malignant neoplasm of esophagus2CTD_human
TgeneTP53C0677776Hereditary Breast and Ovarian Cancer Syndrome2ORPHANET
TgeneTP53C0751851Arsenic Encephalopathy2CTD_human
TgeneTP53C0751852Arsenic Induced Polyneuropathy2CTD_human
TgeneTP53C1168401Squamous cell carcinoma of the head and neck2CTD_human
TgeneTP53C1261473Sarcoma2CGI;CTD_human;GENOMICS_ENGLAND
TgeneTP53C1708349Hereditary Diffuse Gastric Cancer2CTD_human
TgeneTP53C0001430Adenoma1CTD_human
TgeneTP53C0001624Adrenal Gland Neoplasms1CTD_human
TgeneTP53C0002152Alloxan Diabetes1CTD_human
TgeneTP53C0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneTP53C0004698Balkan Nephropathy1CTD_human
TgeneTP53C0006413Burkitt Lymphoma1ORPHANET
TgeneTP53C0006663Calcinosis1CTD_human
TgeneTP53C0007114Malignant neoplasm of skin1CTD_human
TgeneTP53C0007138Carcinoma, Transitional Cell1CTD_human
TgeneTP53C0007194Hypertrophic Cardiomyopathy1CTD_human
TgeneTP53C0007273Carotid Artery Diseases1CTD_human
TgeneTP53C0007621Neoplastic Cell Transformation1CTD_human
TgeneTP53C0007786Brain Ischemia1CTD_human
TgeneTP53C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneTP53C0011303Demyelinating Diseases1CTD_human
TgeneTP53C0011304Demyelination1CTD_human
TgeneTP53C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneTP53C0013990Pathological accumulation of air in tissues1CTD_human
TgeneTP53C0018923Hemangiosarcoma1CTD_human
TgeneTP53C0019207Hepatoma, Morris1CTD_human
TgeneTP53C0019208Hepatoma, Novikoff1CTD_human
TgeneTP53C0020538Hypertensive disease1CTD_human
TgeneTP53C0021361Female infertility1CTD_human
TgeneTP53C0021364Male infertility1CTD_human
TgeneTP53C0022116Ischemia1CTD_human
TgeneTP53C0022660Kidney Failure, Acute1CTD_human
TgeneTP53C0022783Vulvar Lichen Sclerosus1CTD_human
TgeneTP53C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneTP53C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneTP53C0023897Liver Diseases, Parasitic1CTD_human
TgeneTP53C0023904Liver Neoplasms, Experimental1CTD_human
TgeneTP53C0024117Chronic Obstructive Airway Disease1CTD_human
TgeneTP53C0024809Marijuana Abuse1PSYGENET
TgeneTP53C0026640Mouth Neoplasms1CTD_human
TgeneTP53C0027022Myeloproliferative disease1CTD_human
TgeneTP53C0027627Neoplasm Metastasis1CTD_human
TgeneTP53C0027708Nephroblastoma1CTD_human
TgeneTP53C0030246Pustulosis of Palms and Soles1CTD_human
TgeneTP53C0030849Penile Neoplasms1CTD_human
TgeneTP53C0032578Polyploidy1CTD_human
TgeneTP53C0033860Psoriasis1CTD_human
TgeneTP53C0036341Schizophrenia1CTD_human
TgeneTP53C0037286Skin Neoplasms1CTD_human
TgeneTP53C0038279Sterility, Postpartum1CTD_human
TgeneTP53C0038433Streptozotocin Diabetes1CTD_human
TgeneTP53C0040100Thymoma1CTD_human
TgeneTP53C0040136Thyroid Neoplasm1CTD_human
TgeneTP53C0042065Genitourinary Neoplasms1CTD_human
TgeneTP53C0042076Urologic Neoplasms1CTD_human
TgeneTP53C0079772T-Cell Lymphoma1CTD_human
TgeneTP53C0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneTP53C0085136Central Nervous System Neoplasms1CTD_human
TgeneTP53C0086404Experimental Hepatoma1CTD_human
TgeneTP53C0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneTP53C0153381Malignant neoplasm of mouth1CTD_human
TgeneTP53C0153601Malignant neoplasm of penis1CTD_human
TgeneTP53C0205646Adenoma, Basal Cell1CTD_human
TgeneTP53C0205647Follicular adenoma1CTD_human
TgeneTP53C0205648Adenoma, Microcystic1CTD_human
TgeneTP53C0205649Adenoma, Monomorphic1CTD_human
TgeneTP53C0205650Papillary adenoma1CTD_human
TgeneTP53C0205651Adenoma, Trabecular1CTD_human
TgeneTP53C0205770Choroid Plexus Papilloma1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneTP53C0205944Sarcoma, Epithelioid1CTD_human
TgeneTP53C0205945Sarcoma, Spindle Cell1CTD_human
TgeneTP53C0205969Thymic Carcinoma1CGI;CTD_human
TgeneTP53C0206681Adenocarcinoma, Clear Cell1CTD_human
TgeneTP53C0206698Cholangiocarcinoma1CTD_human
TgeneTP53C0206726gliosarcoma1ORPHANET
TgeneTP53C0235874Disease Exacerbation1CTD_human
TgeneTP53C0262584Carcinoma, Small Cell1CTD_human
TgeneTP53C0263628Tumoral calcinosis1CTD_human
TgeneTP53C0263859Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome1CTD_human
TgeneTP53C0279607Adult Hepatocellular Carcinoma1ORPHANET
TgeneTP53C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTP53C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneTP53C0334588Giant Cell Glioblastoma1ORPHANET
TgeneTP53C0341869Subfertility, Female1CTD_human
TgeneTP53C0345905Intrahepatic Cholangiocarcinoma1CTD_human
TgeneTP53C0345967Malignant mesothelioma1CTD_human
TgeneTP53C0376407Granulomatous Slack Skin1CTD_human
TgeneTP53C0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneTP53C0428791Aortic valve calcification1CTD_human
TgeneTP53C0431109Choroid Plexus Carcinoma1ORPHANET
TgeneTP53C0521174Microcalcification1CTD_human
TgeneTP53C0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneTP53C0549473Thyroid carcinoma1CGI;CTD_human
TgeneTP53C0577631Carotid Atherosclerosis1CTD_human
TgeneTP53C0600178External Carotid Artery Diseases1CTD_human
TgeneTP53C0750887Adrenal Cancer1CTD_human
TgeneTP53C0750986Internal Carotid Artery Diseases1CTD_human
TgeneTP53C0750987Arterial Diseases, Common Carotid1CTD_human
TgeneTP53C0751569Genitourinary Cancer1CTD_human
TgeneTP53C0751571Cancer of Urinary Tract1CTD_human
TgeneTP53C0751620Central Nervous System Neoplasms, Primary1CTD_human
TgeneTP53C0848676Subfertility, Male1CTD_human
TgeneTP53C0876994Cardiotoxicity1CTD_human
TgeneTP53C0917730Female sterility1CTD_human
TgeneTP53C0917731Male sterility1CTD_human
TgeneTP53C0917798Cerebral Ischemia1CTD_human
TgeneTP53C0919267ovarian neoplasm1CGI;CTD_human
TgeneTP53C1140680Malignant neoplasm of ovary1CGI;CTD_human
TgeneTP53C1176475Ductal Carcinoma1CTD_human
TgeneTP53C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
TgeneTP53C1527303Chronic Airflow Obstruction1CTD_human
TgeneTP53C1565662Acute Kidney Insufficiency1CTD_human
TgeneTP53C1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human
TgeneTP53C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneTP53C2350037Clinically Isolated Syndrome, CNS Demyelinating1CTD_human
TgeneTP53C2609414Acute kidney injury1CTD_human
TgeneTP53C2713368Hematopoetic Myelodysplasia1CTD_human
TgeneTP53C2930471Bilateral Wilms Tumor1CTD_human
TgeneTP53C2930974Acute erythroleukemia1CTD_human
TgeneTP53C2930975Acute erythroleukemia - M6a subtype1CTD_human
TgeneTP53C2930976Acute myeloid leukemia FAB-M61CTD_human
TgeneTP53C2930977Acute erythroleukemia - M6b subtype1CTD_human
TgeneTP53C2931038Pancreatic carcinoma, familial1ORPHANET
TgeneTP53C2931713Chromosome 17 deletion1CTD_human
TgeneTP53C2931822Nasopharyngeal carcinoma1CTD_human;GENOMICS_ENGLAND
TgeneTP53C3463824MYELODYSPLASTIC SYNDROME1CTD_human
TgeneTP53C3683846Chromosome 17p Deletion Syndrome1CTD_human
TgeneTP53C3805278Extrahepatic Cholangiocarcinoma1CTD_human
TgeneTP53C4551472Hypertrophic obstructive cardiomyopathy1CTD_human
TgeneTP53C4721610Carcinoma, Ovarian Epithelial1CTD_human