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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FYN-DYM (FusionGDB2 ID:31819)

Fusion Gene Summary for FYN-DYM

check button Fusion gene summary
Fusion gene informationFusion gene name: FYN-DYM
Fusion gene ID: 31819
HgeneTgene
Gene symbol

FYN

DYM

Gene ID

2534

54808

Gene nameFYN proto-oncogene, Src family tyrosine kinasedymeclin
SynonymsSLK|SYN|p59-FYNDMC|SMC
Cytomap

6q21

18q21.1

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase FynFYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T)dymeclindyggve-Melchior-Clausen syndrome protein
Modification date2020032720200313
UniProtAcc.

Q7RTS9

Ensembl transtripts involved in fusion geneENST00000368682, ENST00000354650, 
ENST00000229471, ENST00000368667, 
ENST00000368678, ENST00000229470, 
ENST00000356013, ENST00000538466, 
ENST00000476769, 		ENST00000442713, 
ENST00000269445, ENST00000584977, 
ENST00000578396, 
Fusion gene scores* DoF score10 X 9 X 7=63019 X 11 X 13=2717
# samples 1124
** MAII scorelog2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2717*10)=-3.50090825461346
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FYN [Title/Abstract] AND DYM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFYN(112101768)-DYM(46812986), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFYN

GO:0050852

T cell receptor signaling pathway

7722293


check buttonFusion gene breakpoints across FYN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DYM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-18-4086FYNchr6

112101768

-DYMchr18

46812986

-


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Fusion Gene ORF analysis for FYN-DYM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000368682ENST00000442713FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-3CDSENST00000368682ENST00000269445FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000368682ENST00000584977FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000368682ENST00000578396FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-3CDSENST00000354650ENST00000442713FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-3CDSENST00000354650ENST00000269445FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000354650ENST00000584977FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000354650ENST00000578396FYNchr6

112101768

-DYMchr18

46812986

-
intron-3CDSENST00000229471ENST00000442713FYNchr6

112101768

-DYMchr18

46812986

-
intron-3CDSENST00000229471ENST00000269445FYNchr6

112101768

-DYMchr18

46812986

-
intron-intronENST00000229471ENST00000584977FYNchr6

112101768

-DYMchr18

46812986

-
intron-intronENST00000229471ENST00000578396FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-3CDSENST00000368667ENST00000442713FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-3CDSENST00000368667ENST00000269445FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000368667ENST00000584977FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000368667ENST00000578396FYNchr6

112101768

-DYMchr18

46812986

-
intron-3CDSENST00000368678ENST00000442713FYNchr6

112101768

-DYMchr18

46812986

-
intron-3CDSENST00000368678ENST00000269445FYNchr6

112101768

-DYMchr18

46812986

-
intron-intronENST00000368678ENST00000584977FYNchr6

112101768

-DYMchr18

46812986

-
intron-intronENST00000368678ENST00000578396FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-3CDSENST00000229470ENST00000442713FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-3CDSENST00000229470ENST00000269445FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000229470ENST00000584977FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000229470ENST00000578396FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-3CDSENST00000356013ENST00000442713FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-3CDSENST00000356013ENST00000269445FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000356013ENST00000584977FYNchr6

112101768

-DYMchr18

46812986

-
5UTR-intronENST00000356013ENST00000578396FYNchr6

112101768

-DYMchr18

46812986

-
intron-3CDSENST00000538466ENST00000442713FYNchr6

112101768

-DYMchr18

46812986

-
intron-3CDSENST00000538466ENST00000269445FYNchr6

112101768

-DYMchr18

46812986

-
intron-intronENST00000538466ENST00000584977FYNchr6

112101768

-DYMchr18

46812986

-
intron-intronENST00000538466ENST00000578396FYNchr6

112101768

-DYMchr18

46812986

-
intron-3CDSENST00000476769ENST00000442713FYNchr6

112101768

-DYMchr18

46812986

-
intron-3CDSENST00000476769ENST00000269445FYNchr6

112101768

-DYMchr18

46812986

-
intron-intronENST00000476769ENST00000584977FYNchr6

112101768

-DYMchr18

46812986

-
intron-intronENST00000476769ENST00000578396FYNchr6

112101768

-DYMchr18

46812986

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FYN-DYM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for FYN-DYM


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DYM

Q7RTS9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Necessary for correct organization of Golgi apparatus. Involved in bone development. {ECO:0000269|PubMed:21280149}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FYN-DYM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FYN-DYM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FYN-DYM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FYN-DYM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFYNC0005586Bipolar Disorder2PSYGENET
HgeneFYNC0036341Schizophrenia2PSYGENET
HgeneFYNC0001969Alcoholic Intoxication1PSYGENET
HgeneFYNC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneFYNC0007370Catalepsy1CTD_human
HgeneFYNC0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneFYNC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFYNC0024623Malignant neoplasm of stomach1CTD_human
HgeneFYNC0034069Pulmonary Fibrosis1CTD_human
HgeneFYNC0038356Stomach Neoplasms1CTD_human
HgeneFYNC0079774Peripheral T-Cell Lymphoma1CTD_human
HgeneFYNC0085762Alcohol abuse1PSYGENET
HgeneFYNC0233612Waxy flexibility1CTD_human
HgeneFYNC1708349Hereditary Diffuse Gastric Cancer1CTD_human
HgeneFYNC4721507Alveolitis, Fibrosing1CTD_human
TgeneDYMC0265286Dyggve-Melchior-Clausen syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneDYMC3888088SMITH-MCCORT DYSPLASIA 14GENOMICS_ENGLAND;UNIPROT
TgeneDYMC1846431SMITH-MCCORT DYSPLASIA2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneDYMC0036341Schizophrenia1PSYGENET